Should you encounter any unexpected behaviour,
please let us know.

* 1RE5 *

CA distance fluctuations for 23010418392238138

--- normal mode 8 ---

This matrix displays the maximum distance fluctuations between all pairs of CA atoms and between the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Distance increases are plotted in blue and decreases in red for the strongest 10% of the residue pair distance changes. Every pixel corresponds to a single residue. Grey lines are drawn every 10 residues, yellow lines every 100 residues (counting from the upper left corner).

The following table indicates for every residue the two corresponding residues with the strongest CA distance fluctuations.

[HELP on distance fluctuations]

GD ok

largest increase ref largest decrease
GLN 393 0.12 ASN 3 -0.04 SER 20

GLN 393 0.14 GLN 4 -0.04 ARG 16

GLN 393 0.15 LEU 5 -0.02 PRO 13

GLN 393 0.15 PHE 6 -0.02 ALA 121

GLN 393 0.15 ASP 7 -0.03 ALA 12

GLN 393 0.16 ALA 8 -0.04 ALA 68

GLN 393 0.17 TYR 9 -0.03 ALA 68

GLN 393 0.15 PHE 10 -0.02 HIS 386

ALA 397 0.15 THR 11 -0.04 SER 335

ALA 397 0.16 ALA 12 -0.04 GLY 65

ALA 397 0.15 PRO 13 -0.06 GLY 65

ALA 397 0.15 ALA 14 -0.05 GLY 65

ALA 397 0.14 MET 15 -0.04 GLY 65

ALA 397 0.13 ARG 16 -0.04 GLY 65

ALA 397 0.13 GLU 17 -0.05 GLY 65

ALA 397 0.13 ILE 18 -0.04 GLY 65

ALA 397 0.12 PHE 19 -0.03 ASN 3

ALA 397 0.12 SER 20 -0.04 ASP 21

ALA 397 0.11 ASP 21 -0.04 SER 20

ALA 397 0.12 ARG 22 -0.04 ARG 22

ALA 397 0.12 GLY 23 -0.03 ASP 21

ALA 397 0.11 ARG 24 -0.03 SER 20

ALA 397 0.11 LEU 25 -0.03 SER 20

ALA 397 0.11 GLN 26 -0.03 ARG 22

ALA 397 0.11 GLY 27 -0.02 GLY 113

ALA 397 0.10 MET 28 -0.02 SER 20

ALA 397 0.10 LEU 29 -0.03 SER 20

ALA 397 0.11 ASP 30 -0.02 ARG 22

ALA 397 0.10 PHE 31 -0.02 SER 20

ALA 397 0.10 GLU 32 -0.02 PRO 13

ALA 397 0.10 ALA 33 -0.02 PRO 13

ALA 397 0.10 ALA 34 -0.02 ARG 22

ALA 397 0.09 LEU 35 -0.02 PRO 13

ALA 397 0.09 ALA 36 -0.02 PRO 13

ALA 397 0.09 ARG 37 -0.02 PRO 13

ALA 397 0.09 ALA 38 -0.02 PRO 13

ALA 397 0.09 GLU 39 -0.02 PRO 13

ALA 397 0.09 ALA 40 -0.02 PRO 13

ALA 397 0.09 SER 41 -0.02 PRO 13

ALA 397 0.08 ALA 42 -0.02 PRO 13

ALA 397 0.08 GLY 43 -0.02 PRO 13

ALA 397 0.08 LEU 44 -0.02 PRO 13

ALA 397 0.09 VAL 45 -0.02 PRO 13

ALA 397 0.09 PRO 46 -0.02 PRO 13

ALA 397 0.09 HIS 47 -0.02 PRO 13

ALA 397 0.09 SER 48 -0.02 PRO 13

ALA 397 0.09 ALA 49 -0.03 LYS 83

ALA 397 0.10 VAL 50 -0.02 PRO 13

ALA 397 0.10 ALA 51 -0.02 PRO 13

ALA 397 0.10 ALA 52 -0.03 PRO 13

ALA 397 0.10 ILE 53 -0.03 PRO 13

ALA 397 0.10 GLU 54 -0.02 PRO 13

ALA 397 0.11 ALA 55 -0.02 PRO 13

ALA 397 0.10 ALA 56 -0.03 PRO 13

ALA 397 0.10 CYS 57 -0.02 GLU 17

ALA 397 0.11 GLN 58 -0.03 ARG 22

ALA 397 0.11 ALA 59 -0.03 ARG 22

ALA 397 0.11 GLU 60 -0.04 ARG 22

ALA 397 0.11 ARG 61 -0.03 GLU 17

ALA 397 0.10 TYR 62 -0.04 PRO 13

ALA 397 0.10 ASP 63 -0.05 PRO 13

ALA 397 0.10 THR 64 -0.05 PRO 13

GLN 393 0.10 GLY 65 -0.07 PRO 13

ALA 397 0.10 ALA 66 -0.05 PRO 13

ALA 397 0.10 LEU 67 -0.04 PRO 13

GLN 393 0.10 ALA 68 -0.05 PRO 13

GLN 393 0.09 ASN 69 -0.05 PRO 13

ALA 397 0.09 ALA 70 -0.03 ALA 84

ALA 397 0.09 ILE 71 -0.03 ALA 121

GLN 393 0.09 ALA 72 -0.03 LEU 124

GLN 393 0.08 THR 73 -0.03 ARG 98

ALA 397 0.08 ALA 74 -0.03 ARG 98

ALA 397 0.08 GLY 75 -0.03 VAL 290

ALA 397 0.09 ASN 76 -0.02 ALA 121

ALA 397 0.09 SER 77 -0.03 ALA 121

ALA 397 0.09 ALA 78 -0.02 ASP 120

ALA 397 0.09 ILE 79 -0.03 ARG 98

ALA 397 0.09 PRO 80 -0.03 PRO 13

ALA 397 0.09 LEU 81 -0.03 PRO 13

ALA 397 0.09 VAL 82 -0.03 PRO 13

ALA 397 0.09 LYS 83 -0.05 GLY 86

ALA 397 0.09 ALA 84 -0.04 PRO 13

ALA 397 0.09 LEU 85 -0.03 PRO 13

ALA 397 0.09 GLY 86 -0.05 LYS 83

ALA 397 0.09 LYS 87 -0.04 PRO 13

ALA 397 0.09 VAL 88 -0.03 PRO 13

ALA 397 0.09 ILE 89 -0.03 PRO 13

ALA 397 0.09 ALA 90 -0.03 PRO 13

ALA 397 0.09 THR 91 -0.03 PRO 13

ALA 397 0.09 GLY 92 -0.03 PRO 13

ALA 397 0.09 VAL 93 -0.03 PRO 13

ALA 397 0.09 PRO 94 -0.03 PRO 13

ALA 397 0.08 GLU 95 -0.03 PRO 13

ALA 397 0.09 ALA 96 -0.03 PRO 13

ALA 397 0.09 GLU 97 -0.03 LYS 83

ALA 397 0.08 ARG 98 -0.03 ALA 74

ALA 397 0.09 TYR 99 -0.02 ALA 74

ALA 397 0.09 VAL 100 -0.02 PRO 13

ALA 397 0.09 HIS 101 -0.02 PRO 13

ALA 397 0.08 LEU 102 -0.02 ASP 120

ALA 397 0.08 GLY 103 -0.02 ASP 120

ALA 397 0.08 ALA 104 -0.02 ASP 120

ALA 397 0.08 THR 105 -0.02 ALA 121

ALA 397 0.09 SER 106 -0.02 ALA 121

ALA 397 0.09 GLN 107 -0.02 ALA 121

ALA 397 0.09 ASP 108 -0.02 ASP 120

ALA 397 0.09 ALA 109 -0.02 SER 20

ALA 397 0.10 MET 110 -0.02 SER 20

ALA 397 0.09 ASP 111 -0.02 SER 20

ALA 397 0.10 THR 112 -0.02 GLY 65

ALA 397 0.10 GLY 113 -0.02 GLY 27

ALA 397 0.10 LEU 114 -0.02 GLY 65

ALA 397 0.10 VAL 115 -0.02 GLY 65

ALA 397 0.11 LEU 116 -0.03 GLY 65

ALA 397 0.11 GLN 117 -0.03 GLY 65

ALA 397 0.11 LEU 118 -0.03 GLY 65

ALA 397 0.11 ARG 119 -0.03 GLY 65

ALA 397 0.11 ASP 120 -0.04 GLY 65

ALA 397 0.12 ALA 121 -0.03 GLY 65

ALA 397 0.12 LEU 122 -0.03 GLY 65

ALA 397 0.12 ASP 123 -0.03 GLY 65

ALA 397 0.13 LEU 124 -0.03 GLY 65

ALA 397 0.13 ILE 125 -0.03 GLY 65

ALA 397 0.13 GLU 126 -0.03 HIS 386

ALA 397 0.14 ALA 127 -0.03 GLY 65

ALA 397 0.15 ASP 128 -0.03 HIS 386

ALA 397 0.13 LEU 129 -0.03 HIS 386

ALA 397 0.13 GLY 130 -0.03 HIS 386

ALA 397 0.14 LYS 131 -0.03 HIS 386

ALA 397 0.15 LEU 132 -0.03 HIS 386

ALA 397 0.14 ALA 133 -0.04 HIS 386

ALA 397 0.14 ASP 134 -0.03 HIS 386

ALA 397 0.16 THR 135 -0.03 HIS 386

ALA 397 0.15 LEU 136 -0.04 HIS 386

ALA 397 0.14 SER 137 -0.04 HIS 386

ALA 397 0.14 GLN 138 -0.04 HIS 386

ALA 397 0.16 GLN 139 -0.04 HIS 386

ALA 397 0.14 ALA 140 -0.04 HIS 386

GLU 398 0.13 LEU 141 -0.04 HIS 386

GLU 398 0.15 LYS 142 -0.04 HIS 386

GLU 398 0.15 HIS 143 -0.04 HIS 386

GLU 398 0.13 ALA 144 -0.04 HIS 386

GLU 398 0.12 ASP 145 -0.05 HIS 386

GLU 398 0.14 THR 146 -0.04 HIS 386

GLN 399 0.12 PRO 147 -0.05 HIS 386

GLN 399 0.12 LEU 148 -0.05 GLU 60

GLN 399 0.10 VAL 149 -0.05 GLU 60

GLN 399 0.09 GLY 150 -0.05 GLU 60

GLN 399 0.08 ARG 151 -0.05 GLU 60

ALA 397 0.07 THR 152 -0.06 GLU 60

ALA 397 0.07 TRP 153 -0.06 GLU 60

ALA 397 0.07 LEU 154 -0.05 GLU 60

GLN 399 0.06 GLN 155 -0.06 GLU 60

GLN 399 0.07 HIS 156 -0.06 GLU 60

GLN 399 0.07 ALA 157 -0.06 GLU 60

GLN 399 0.07 THR 158 -0.06 GLU 60

GLN 399 0.08 PRO 159 -0.06 GLU 60

GLN 399 0.10 VAL 160 -0.05 HIS 386

GLU 398 0.12 THR 161 -0.05 HIS 386

GLU 398 0.14 LEU 162 -0.04 HIS 386

GLU 398 0.13 GLY 163 -0.04 HIS 386

GLU 398 0.11 MET 164 -0.05 HIS 386

ALA 397 0.12 LYS 165 -0.05 HIS 386

ALA 397 0.14 LEU 166 -0.04 HIS 386

ALA 397 0.12 ALA 167 -0.05 HIS 386

ALA 397 0.11 GLY 168 -0.05 HIS 386

ALA 397 0.13 VAL 169 -0.04 HIS 386

ALA 397 0.12 LEU 170 -0.04 HIS 386

ALA 397 0.11 GLY 171 -0.05 HIS 386

ALA 397 0.11 ALA 172 -0.05 HIS 386

ALA 397 0.12 LEU 173 -0.04 HIS 386

ALA 397 0.11 THR 174 -0.04 HIS 386

ALA 397 0.10 ARG 175 -0.05 HIS 386

ALA 397 0.11 HIS 176 -0.04 HIS 386

ALA 397 0.11 ARG 177 -0.04 HIS 386

ALA 397 0.10 GLN 178 -0.04 HIS 386

ALA 397 0.10 ARG 179 -0.04 HIS 386

ALA 397 0.10 LEU 180 -0.03 HIS 386

ALA 397 0.10 GLN 181 -0.03 HIS 386

ALA 397 0.09 GLU 182 -0.04 HIS 386

ALA 397 0.10 LEU 183 -0.04 HIS 386

ALA 397 0.10 ARG 184 -0.03 HIS 386

ALA 397 0.09 PRO 185 -0.03 HIS 386

ALA 397 0.09 ARG 186 -0.03 HIS 386

ALA 397 0.10 LEU 187 -0.03 HIS 386

ALA 397 0.10 LEU 188 -0.02 HIS 386

ALA 397 0.09 VAL 189 -0.02 HIS 386

ALA 397 0.09 LEU 190 -0.02 THR 220

ALA 397 0.09 GLN 191 -0.02 GLY 65

ALA 397 0.09 PHE 192 -0.02 GLN 393

ALA 397 0.08 GLY 193 -0.02 GLN 393

ALA 397 0.08 GLY 194 -0.02 ASP 120

ALA 397 0.08 ALA 195 -0.02 ILE 344

ALA 397 0.07 SER 196 -0.02 ILE 344

ALA 397 0.08 GLY 197 -0.02 GLN 393

ALA 397 0.07 SER 198 -0.01 GLN 393

ALA 397 0.08 LEU 199 -0.01 ASP 120

ALA 397 0.07 ALA 200 -0.02 LEU 44

ALA 397 0.08 ALA 201 -0.02 ILE 344

ALA 397 0.08 LEU 202 -0.02 LEU 44

ALA 397 0.07 GLY 203 -0.02 LEU 431

ALA 397 0.07 SER 204 -0.01 VAL 343

ALA 397 0.08 LYS 205 -0.01 ASP 120

ALA 397 0.08 ALA 206 -0.01 ASP 120

ALA 397 0.08 MET 207 -0.02 GLN 393

ALA 397 0.08 PRO 208 -0.01 SER 20

ALA 397 0.08 VAL 209 -0.02 PRO 13

ALA 397 0.09 ALA 210 -0.02 SER 20

ALA 397 0.09 GLU 211 -0.02 GLY 65

ALA 397 0.09 ALA 212 -0.02 GLY 65

ALA 397 0.09 LEU 213 -0.02 SER 20

ALA 397 0.09 ALA 214 -0.02 GLY 65

ALA 397 0.10 GLU 215 -0.02 GLY 65

ALA 397 0.10 GLN 216 -0.02 GLY 65

ALA 397 0.10 LEU 217 -0.02 GLY 65

ALA 397 0.10 LYS 218 -0.02 GLY 65

ALA 397 0.10 LEU 219 -0.02 GLY 65

ALA 397 0.09 THR 220 -0.02 LEU 190

ALA 397 0.09 LEU 221 -0.02 GLN 393

ALA 397 0.08 PRO 222 -0.02 GLN 393

ALA 397 0.08 GLU 223 -0.03 GLN 393

ALA 397 0.08 GLN 224 -0.02 GLN 393

ALA 397 0.08 PRO 225 -0.02 GLN 393

ALA 397 0.08 TRP 226 -0.02 GLN 393

ALA 397 0.08 HIS 227 -0.02 GLU 389

ALA 397 0.08 THR 228 -0.02 GLU 389

ALA 397 0.08 GLN 229 -0.03 GLU 389

ALA 397 0.08 ARG 230 -0.03 GLU 389

ALA 397 0.08 ASP 231 -0.04 GLU 389

ALA 397 0.09 ARG 232 -0.03 HIS 386

ALA 397 0.09 LEU 233 -0.03 HIS 386

ALA 397 0.09 VAL 234 -0.03 GLU 389

ALA 397 0.09 GLU 235 -0.04 HIS 386

ALA 397 0.10 PHE 236 -0.03 HIS 386

ALA 397 0.10 ALA 237 -0.03 HIS 386

ALA 397 0.10 SER 238 -0.04 HIS 386

ALA 397 0.10 VAL 239 -0.04 HIS 386

ALA 397 0.11 LEU 240 -0.03 HIS 386

ALA 397 0.11 GLY 241 -0.04 HIS 386

ALA 397 0.11 LEU 242 -0.04 HIS 386

ALA 397 0.12 VAL 243 -0.04 HIS 386

ALA 397 0.12 ALA 244 -0.04 HIS 386

ALA 397 0.11 GLY 245 -0.04 HIS 386

ALA 397 0.12 SER 246 -0.04 HIS 386

ALA 397 0.13 LEU 247 -0.04 HIS 386

ALA 397 0.13 GLY 248 -0.04 HIS 386

ALA 397 0.12 LYS 249 -0.04 HIS 386

ALA 397 0.14 PHE 250 -0.04 HIS 386

ALA 397 0.15 GLY 251 -0.04 HIS 386

ALA 397 0.13 ARG 252 -0.04 HIS 386

ALA 397 0.14 ASP 253 -0.04 HIS 386

ALA 397 0.16 ILE 254 -0.04 HIS 386

ALA 397 0.15 SER 255 -0.03 HIS 386

VAL 396 0.13 LEU 256 -0.04 HIS 386

ALA 397 0.15 LEU 257 -0.04 HIS 386

VAL 396 0.19 MET 258 -0.03 HIS 386

VAL 396 0.15 GLN 259 -0.03 HIS 386

THR 362 0.17 THR 260 -0.03 HIS 386

LEU 361 0.11 GLU 261 -0.04 HIS 386

GLN 399 0.14 ALA 262 -0.04 GLU 60

GLN 399 0.20 GLY 263 -0.03 HIS 386

GLN 399 0.20 GLU 264 -0.04 GLU 60

ALA 397 0.21 VAL 265 -0.04 HIS 386

ALA 397 0.24 PHE 266 -0.03 HIS 386

ALA 397 0.24 GLU 267 -0.03 HIS 386

ALA 397 0.27 PRO 268 -0.03 PRO 94

ALA 397 0.30 SER 269 -0.04 PRO 94

GLN 393 0.27 ALA 270 -0.04 ARG 98

ALA 397 0.25 PRO 271 -0.04 PRO 94

VAL 396 0.28 LYS 282 -0.04 ARG 98

VAL 396 0.29 ARG 283 -0.04 ARG 98

VAL 396 0.22 ASN 284 -0.04 ARG 98

ALA 397 0.20 PRO 285 -0.03 ARG 98

GLN 393 0.19 VAL 286 -0.03 ARG 98

ALA 397 0.19 GLY 287 -0.03 GLY 75

ALA 397 0.17 ALA 288 -0.03 HIS 386

ALA 397 0.15 ALA 289 -0.04 GLY 75

ALA 397 0.15 VAL 290 -0.05 GLY 75

ALA 397 0.15 LEU 291 -0.03 HIS 386

ALA 397 0.13 ILE 292 -0.03 HIS 386

ALA 397 0.13 GLY 293 -0.03 HIS 386

ALA 397 0.13 ALA 294 -0.03 HIS 386

ALA 397 0.12 ALA 295 -0.04 HIS 386

ALA 397 0.11 THR 296 -0.04 HIS 386

ALA 397 0.11 ARG 297 -0.03 HIS 386

ALA 397 0.11 VAL 298 -0.03 HIS 386

ALA 397 0.10 PRO 299 -0.04 HIS 386

ALA 397 0.09 GLY 300 -0.03 HIS 386

ALA 397 0.10 LEU 301 -0.03 HIS 386

ALA 397 0.10 LEU 302 -0.03 HIS 386

ALA 397 0.09 SER 303 -0.04 GLU 389

ALA 397 0.09 THR 304 -0.03 GLU 389

ALA 397 0.09 LEU 305 -0.03 GLU 389

ALA 397 0.08 PHE 306 -0.04 GLU 389

ALA 397 0.08 ALA 307 -0.04 GLU 389

ALA 397 0.08 ALA 308 -0.03 GLU 389

ALA 397 0.08 MET 309 -0.04 GLU 389

ALA 397 0.07 PRO 310 -0.04 GLU 389

ALA 397 0.08 GLN 311 -0.03 GLU 389

ALA 397 0.07 GLU 312 -0.03 GLU 389

ALA 397 0.07 HIS 313 -0.02 GLN 393

ALA 397 0.07 GLU 314 -0.02 GLN 393

ALA 397 0.08 ARG 315 -0.02 GLU 60

ALA 397 0.08 SER 316 -0.02 GLU 60

ALA 397 0.08 LEU 317 -0.02 GLU 60

ALA 397 0.08 GLY 318 -0.04 GLY 293

ALA 397 0.08 LEU 319 -0.02 GLU 389

ALA 397 0.09 TRP 320 -0.02 GLU 389

ALA 397 0.09 HIS 321 -0.02 ASN 3

ALA 397 0.09 ALA 322 -0.02 GLU 389

ALA 397 0.10 GLU 323 -0.02 GLU 389

ALA 397 0.10 TRP 324 -0.02 GLU 389

ALA 397 0.11 GLU 325 -0.02 GLU 389

ALA 397 0.10 THR 326 -0.02 GLU 389

ALA 397 0.11 LEU 327 -0.02 HIS 386

ALA 397 0.11 PRO 328 -0.02 GLY 65

ALA 397 0.11 ASP 329 -0.02 HIS 386

ALA 397 0.12 ILE 330 -0.03 HIS 386

ALA 397 0.12 CYS 331 -0.02 HIS 386

ALA 397 0.13 CYS 332 -0.03 GLY 65

ALA 397 0.13 LEU 333 -0.03 HIS 386

ALA 397 0.14 VAL 334 -0.03 HIS 386

ALA 397 0.14 SER 335 -0.04 THR 11

ALA 397 0.15 GLY 336 -0.03 ALA 72

ALA 397 0.15 ALA 337 -0.03 HIS 386

ALA 397 0.15 LEU 338 -0.03 HIS 386

ALA 397 0.16 ARG 339 -0.03 ALA 72

ALA 397 0.18 GLN 340 -0.03 ALA 72

ALA 397 0.17 ALA 341 -0.03 HIS 386

ALA 397 0.18 GLN 342 -0.03 HIS 386

ALA 397 0.20 VAL 343 -0.03 LYS 87

ALA 397 0.21 ILE 344 -0.03 LYS 87

ALA 397 0.18 ALA 345 -0.03 HIS 386

ALA 397 0.19 GLU 346 -0.03 HIS 386

ALA 397 0.22 GLY 347 -0.03 PRO 94

ALA 397 0.23 MET 348 -0.03 HIS 386

ALA 397 0.26 GLU 349 -0.03 GLU 60

ALA 397 0.23 VAL 350 -0.04 GLU 60

GLN 399 0.24 ASP 351 -0.04 GLU 60

GLN 399 0.19 ALA 352 -0.04 GLU 60

GLN 399 0.19 ALA 353 -0.04 GLU 60

GLN 399 0.19 ARG 354 -0.04 GLU 60

GLN 399 0.15 MET 355 -0.04 GLU 60

GLN 399 0.12 ARG 356 -0.05 GLU 60

ARG 400 0.12 ARG 357 -0.05 GLU 60

ARG 400 0.11 ASN 358 -0.05 GLU 60

ARG 400 0.09 LEU 359 -0.05 GLU 60

ALA 404 0.07 ASP 360 -0.05 GLU 60

ALA 404 0.06 LEU 361 -0.05 GLU 60

GLY 418 0.04 THR 362 -0.06 GLU 60

ASP 360 0.06 GLN 363 -0.06 GLU 60

ASP 360 0.06 GLY 364 -0.06 GLU 60

GLY 418 0.04 LEU 365 -0.07 GLU 60

GLN 399 0.05 VAL 366 -0.07 GLU 60

GLN 399 0.06 LEU 367 -0.07 GLU 60

ARG 400 0.04 ALA 368 -0.08 GLU 60

GLN 399 0.05 GLU 369 -0.08 GLU 60

GLU 398 0.05 ALA 370 -0.07 GLU 60

ALA 404 0.05 VAL 371 -0.08 GLU 60

GLU 398 0.04 SER 372 -0.09 GLU 60

GLU 398 0.05 ILE 373 -0.09 GLU 60

ASP 145 0.05 VAL 374 -0.08 GLU 60

ASP 145 0.04 LEU 375 -0.09 GLU 60

ASP 145 0.04 ALA 376 -0.09 GLU 60

GLU 398 0.04 GLN 377 -0.09 GLU 60

ASP 145 0.04 ARG 378 -0.09 GLU 60

ASP 145 0.04 LEU 379 -0.09 GLU 60

ASP 145 0.03 GLY 380 -0.10 GLU 60

ASP 145 0.03 ARG 381 -0.10 GLU 60

ASP 145 0.03 ASP 382 -0.11 GLU 60

ASP 145 0.03 ARG 383 -0.10 GLU 60

ASP 145 0.04 ALA 384 -0.10 GLU 60

ASP 145 0.03 HIS 385 -0.10 GLU 60

ASP 145 0.03 HIS 386 -0.11 GLU 60

ASP 145 0.04 LEU 387 -0.10 GLU 60

ALA 368 0.04 LEU 388 -0.09 GLU 60

ASP 360 0.03 GLU 389 -0.11 THR 278

ALA 353 0.03 GLN 390 -0.10 GLU 60

ALA 353 0.04 CYS 391 -0.09 GLU 60

ASP 360 0.04 CYS 392 -0.09 PRO 280

ASP 360 0.03 GLN 393 -0.09 PRO 280

ALA 353 0.03 ARG 394 -0.09 GLU 60

ASP 360 0.04 ALA 395 -0.08 GLU 60

ASP 360 0.03 VAL 396 -0.08 SER 269

ALA 353 0.03 ALA 397 -0.09 SER 269

GLU 419 0.03 GLU 398 -0.08 GLU 60

GLU 419 0.04 GLN 399 -0.07 GLU 60

GLU 419 0.05 ARG 400 -0.07 GLU 60

GLY 418 0.06 HIS 401 -0.07 GLU 60

GLY 418 0.05 LEU 402 -0.07 GLU 60

GLY 418 0.06 ARG 403 -0.07 GLU 60

GLY 418 0.06 ALA 404 -0.07 GLU 60

GLY 418 0.05 VAL 405 -0.08 GLU 60

GLY 418 0.05 LEU 406 -0.08 GLU 60

GLY 418 0.05 GLY 407 -0.07 GLU 60

GLY 418 0.05 ASP 408 -0.08 GLU 60

GLY 418 0.04 GLU 409 -0.08 GLU 60

GLY 418 0.04 PRO 410 -0.08 GLU 60

GLY 418 0.04 GLN 411 -0.09 GLU 60

GLY 418 0.04 VAL 412 -0.08 GLU 60

GLY 418 0.05 SER 413 -0.08 GLU 60

GLY 418 0.04 ALA 414 -0.08 GLU 60

GLY 418 0.04 GLU 415 -0.08 GLU 60

GLY 418 0.05 LEU 416 -0.08 GLU 60

GLY 418 0.06 SER 417 -0.07 GLU 60

GLY 418 0.06 GLY 418 -0.07 GLU 60

GLY 418 0.07 GLU 419 -0.06 GLU 60

ALA 404 0.06 GLU 420 -0.07 GLU 60

GLY 418 0.06 LEU 421 -0.07 GLU 60

ALA 404 0.07 ASP 422 -0.06 GLU 60

ALA 404 0.07 ARG 423 -0.06 GLU 60

ALA 404 0.06 LEU 424 -0.07 GLU 60

ALA 404 0.06 LEU 425 -0.06 GLU 60

ARG 400 0.07 ASP 426 -0.06 GLU 60

GLU 398 0.08 PRO 427 -0.06 GLU 60

GLU 398 0.09 ALA 428 -0.05 GLU 60

GLU 398 0.08 HIS 429 -0.06 GLU 60

GLU 398 0.07 TYR 430 -0.06 GLU 60

GLU 398 0.08 LEU 431 -0.05 GLU 60

GLU 398 0.08 GLY 432 -0.06 HIS 386

GLU 398 0.08 GLN 433 -0.05 HIS 386

GLU 398 0.09 ALA 434 -0.05 HIS 386

GLU 398 0.10 ARG 435 -0.05 HIS 386

GLU 398 0.09 VAL 436 -0.05 HIS 386

GLU 398 0.10 TRP 437 -0.05 HIS 386

GLU 398 0.11 VAL 438 -0.05 HIS 386

GLU 398 0.10 ALA 439 -0.05 HIS 386

GLU 398 0.09 ARG 440 -0.05 HIS 386

ALA 397 0.10 ALA 441 -0.05 HIS 386

ALA 397 0.11 VAL 442 -0.04 HIS 386

GLU 398 0.10 SER 443 -0.04 HIS 386

ALA 397 0.10 GLU 444 -0.05 HIS 386

ALA 397 0.11 HIS 445 -0.04 HIS 386

ALA 397 0.11 GLN 446 -0.04 HIS 386

ALA 397 0.10 ARG 447 -0.04 HIS 386

ALA 397 0.10 PHE 448 -0.04 HIS 386

ALA 397 0.11 THR 449 -0.03 HIS 386

ALA 397 0.10 ALA 450 -0.03 HIS 386

SER 20 0.06 ASN 3 -0.19 ASN 3

ALA 397 0.03 GLN 4 -0.15 ASN 3

GLN 393 0.03 LEU 5 -0.11 ASN 3

ALA 397 0.04 PHE 6 -0.09 HIS 386

ALA 397 0.04 ASP 7 -0.10 ARG 16

ALA 397 0.04 ALA 8 -0.10 HIS 386

ALA 397 0.04 TYR 9 -0.10 GLU 389

ALA 397 0.05 PHE 10 -0.09 GLU 389

ALA 397 0.05 THR 11 -0.09 ARG 16

ALA 397 0.05 ALA 12 -0.10 GLU 389

ALA 397 0.05 PRO 13 -0.12 HIS 386

ALA 397 0.05 ALA 14 -0.10 HIS 386

ALA 397 0.05 MET 15 -0.10 HIS 386

ALA 397 0.05 ARG 16 -0.11 HIS 386

ALA 397 0.04 GLU 17 -0.11 HIS 386

ALA 397 0.05 ILE 18 -0.10 HIS 386

ALA 397 0.05 PHE 19 -0.10 HIS 386

ASN 3 0.06 SER 20 -0.12 GLN 4

ALA 397 0.04 ASP 21 -0.14 GLN 4

ALA 397 0.04 ARG 22 -0.14 GLY 65

ALA 397 0.05 GLY 23 -0.12 GLY 65

ALA 397 0.05 ARG 24 -0.10 GLY 65

ALA 397 0.04 LEU 25 -0.11 GLY 65

ALA 397 0.05 GLN 26 -0.11 GLY 65

ALA 397 0.05 GLY 27 -0.09 HIS 386

ALA 397 0.05 MET 28 -0.09 HIS 386

ALA 397 0.05 LEU 29 -0.09 HIS 386

ALA 397 0.05 ASP 30 -0.10 HIS 386

ALA 397 0.05 PHE 31 -0.09 HIS 386

ALA 397 0.05 GLU 32 -0.09 HIS 386

ALA 397 0.05 ALA 33 -0.09 HIS 386

ALA 397 0.05 ALA 34 -0.09 HIS 386

ALA 397 0.05 LEU 35 -0.08 HIS 386

ALA 397 0.05 ALA 36 -0.08 HIS 386

ALA 397 0.05 ARG 37 -0.08 HIS 386

ALA 397 0.05 ALA 38 -0.08 HIS 386

GLU 398 0.05 GLU 39 -0.08 HIS 386

GLU 398 0.05 ALA 40 -0.08 HIS 386

GLU 398 0.05 SER 41 -0.08 HIS 386

GLU 398 0.05 ALA 42 -0.07 HIS 386

GLU 398 0.05 GLY 43 -0.07 HIS 386

GLU 398 0.05 LEU 44 -0.08 HIS 386

GLU 398 0.04 VAL 45 -0.08 HIS 386

GLU 398 0.04 PRO 46 -0.08 HIS 386

GLU 398 0.04 HIS 47 -0.09 HIS 386

ALA 397 0.04 SER 48 -0.09 HIS 386

ALA 397 0.04 ALA 49 -0.09 HIS 386

ALA 397 0.04 VAL 50 -0.09 HIS 386

ALA 397 0.04 ALA 51 -0.10 HIS 386

ALA 397 0.04 ALA 52 -0.10 HIS 386

ALA 397 0.04 ILE 53 -0.10 HIS 386

ALA 397 0.04 GLU 54 -0.10 HIS 386

ALA 397 0.04 ALA 55 -0.11 HIS 386

ALA 397 0.04 ALA 56 -0.11 ASP 63

ALA 397 0.04 CYS 57 -0.11 GLY 65

ALA 397 0.04 GLN 58 -0.13 GLY 65

ALA 397 0.04 ALA 59 -0.14 GLY 65

ALA 397 0.04 GLU 60 -0.15 GLY 65

ALA 397 0.03 ARG 61 -0.14 ASP 63

ALA 397 0.03 TYR 62 -0.14 GLU 60

ALA 397 0.03 ASP 63 -0.15 GLU 60

ALA 397 0.03 THR 64 -0.15 GLU 60

ALA 397 0.03 GLY 65 -0.16 GLU 60

ALA 397 0.03 ALA 66 -0.14 GLU 60

ALA 397 0.03 LEU 67 -0.13 GLU 60

ALA 397 0.03 ALA 68 -0.12 GLU 60

ALA 397 0.03 ASN 69 -0.12 GLU 60

ALA 397 0.03 ALA 70 -0.11 GLU 60

ALA 397 0.03 ILE 71 -0.10 GLU 60

ALA 397 0.03 ALA 72 -0.09 GLU 60

VAL 343 0.03 THR 73 -0.09 GLU 60

VAL 286 0.07 ALA 74 -0.09 GLU 389

VAL 286 0.05 GLY 75 -0.08 GLU 60

ALA 397 0.04 ASN 76 -0.08 GLU 60

ALA 397 0.04 SER 77 -0.09 GLU 60

ALA 397 0.05 ALA 78 -0.09 GLU 60

VAL 286 0.04 ILE 79 -0.09 GLU 60

ALA 397 0.04 PRO 80 -0.11 GLU 60

ALA 397 0.04 LEU 81 -0.11 GLU 60

ALA 397 0.04 VAL 82 -0.10 GLU 60

ALA 397 0.03 LYS 83 -0.10 GLU 60

ALA 397 0.03 ALA 84 -0.12 GLU 60

ALA 397 0.04 LEU 85 -0.11 GLU 60

ALA 397 0.04 GLY 86 -0.11 GLU 60

ALA 397 0.03 LYS 87 -0.12 GLU 60

ALA 397 0.03 VAL 88 -0.12 GLU 60

ALA 397 0.04 ILE 89 -0.11 GLU 60

ALA 397 0.03 ALA 90 -0.11 GLU 60

ALA 397 0.03 THR 91 -0.12 THR 91

ALA 397 0.03 GLY 92 -0.12 THR 91

ALA 397 0.03 VAL 93 -0.11 THR 91

ALA 397 0.03 PRO 94 -0.11 THR 91

ALA 397 0.04 GLU 95 -0.10 THR 91

ALA 397 0.04 ALA 96 -0.10 THR 91

ALA 397 0.04 GLU 97 -0.10 GLU 60

ALA 397 0.04 ARG 98 -0.09 GLU 60

ALA 397 0.04 TYR 99 -0.09 GLU 60

ALA 397 0.04 VAL 100 -0.09 GLU 60

ALA 397 0.05 HIS 101 -0.08 GLU 60

ALA 397 0.05 LEU 102 -0.08 GLU 60

ALA 397 0.05 GLY 103 -0.07 HIS 386

ALA 397 0.06 ALA 104 -0.07 HIS 386

ALA 397 0.06 THR 105 -0.07 GLU 60

ALA 397 0.05 SER 106 -0.08 GLU 60

ALA 397 0.06 GLN 107 -0.07 HIS 386

ALA 397 0.06 ASP 108 -0.07 HIS 386

ALA 397 0.06 ALA 109 -0.08 HIS 386

ALA 397 0.06 MET 110 -0.08 HIS 386

ALA 397 0.06 ASP 111 -0.07 HIS 386

ALA 397 0.06 THR 112 -0.08 HIS 386

ALA 397 0.06 GLY 113 -0.08 HIS 386

ALA 397 0.06 LEU 114 -0.08 HIS 386

ALA 397 0.06 VAL 115 -0.08 HIS 386

ALA 397 0.06 LEU 116 -0.08 HIS 386

ALA 397 0.06 GLN 117 -0.09 HIS 386

ALA 397 0.06 LEU 118 -0.08 HIS 386

ALA 397 0.06 ARG 119 -0.08 HIS 386

ALA 397 0.06 ASP 120 -0.08 HIS 386

ALA 397 0.06 ALA 121 -0.08 HIS 386

ALA 397 0.06 LEU 122 -0.07 HIS 386

ALA 397 0.06 ASP 123 -0.08 HIS 386

ALA 397 0.06 LEU 124 -0.08 HIS 386

ALA 397 0.06 ILE 125 -0.07 HIS 386

ALA 397 0.06 GLU 126 -0.07 HIS 386

ALA 397 0.06 ALA 127 -0.07 HIS 386

ALA 397 0.06 ASP 128 -0.08 GLU 389

ALA 397 0.06 LEU 129 -0.06 GLU 389

ALA 397 0.06 GLY 130 -0.06 GLN 390

ALA 397 0.06 LYS 131 -0.07 GLN 393

ALA 397 0.06 LEU 132 -0.07 GLN 393

ALA 397 0.06 ALA 133 -0.06 GLN 393

ALA 397 0.06 ASP 134 -0.06 GLN 393

ALA 397 0.06 THR 135 -0.06 ALA 397

ALA 397 0.06 LEU 136 -0.06 GLN 393

ALA 397 0.06 SER 137 -0.05 ALA 397

ALA 397 0.06 GLN 138 -0.05 ALA 397

ALA 397 0.06 GLN 139 -0.06 ALA 397

ALA 397 0.06 ALA 140 -0.04 ALA 397

ALA 397 0.06 LEU 141 -0.04 ALA 397

ALA 397 0.06 LYS 142 -0.05 ALA 397

ALA 397 0.06 HIS 143 -0.04 ALA 397

ALA 397 0.06 ALA 144 -0.03 ALA 397

ALA 397 0.06 ASP 145 -0.02 ALA 397

ALA 397 0.06 THR 146 -0.02 ALA 397

ALA 397 0.06 PRO 147 -0.02 GLY 92

ALA 397 0.06 LEU 148 -0.02 GLU 60

ALA 397 0.07 VAL 149 -0.02 GLU 60

ALA 397 0.07 GLY 150 -0.02 GLU 60

ALA 397 0.07 ARG 151 -0.02 GLU 60

ALA 397 0.08 THR 152 -0.02 GLU 60

ALA 397 0.08 TRP 153 -0.02 GLU 60

ALA 397 0.07 LEU 154 -0.03 GLU 60

ALA 397 0.07 GLN 155 -0.02 GLU 60

ALA 397 0.07 HIS 156 -0.02 GLU 60

ALA 397 0.07 ALA 157 -0.02 GLU 60

ALA 397 0.07 THR 158 -0.02 GLY 347

ALA 397 0.07 PRO 159 -0.02 GLU 60

ALA 397 0.07 VAL 160 -0.02 GLN 393

ALA 397 0.07 THR 161 -0.02 GLN 393

ALA 397 0.06 LEU 162 -0.03 ALA 397

ALA 397 0.06 GLY 163 -0.03 ALA 397

ALA 397 0.07 MET 164 -0.03 GLN 393

ALA 397 0.07 LYS 165 -0.03 GLN 393

ALA 397 0.07 LEU 166 -0.04 GLN 393

ALA 397 0.07 ALA 167 -0.04 GLN 393

ALA 397 0.07 GLY 168 -0.04 GLN 393

ALA 397 0.07 VAL 169 -0.04 GLN 393

ALA 397 0.07 LEU 170 -0.05 GLN 393

ALA 397 0.07 GLY 171 -0.04 GLN 393

ALA 397 0.08 ALA 172 -0.04 GLN 393

ALA 397 0.07 LEU 173 -0.05 GLN 393

ALA 397 0.07 THR 174 -0.04 GLN 393

ALA 397 0.08 ARG 175 -0.04 HIS 386

ALA 397 0.08 HIS 176 -0.05 HIS 386

ALA 397 0.07 ARG 177 -0.05 HIS 386

ALA 397 0.08 GLN 178 -0.05 HIS 386

ALA 397 0.08 ARG 179 -0.05 HIS 386

ALA 397 0.07 LEU 180 -0.06 HIS 386

ALA 397 0.07 GLN 181 -0.05 HIS 386

ALA 397 0.08 GLU 182 -0.05 HIS 386

ALA 397 0.08 LEU 183 -0.05 HIS 386

ALA 397 0.07 ARG 184 -0.06 HIS 386

ALA 397 0.08 PRO 185 -0.06 HIS 386

ALA 397 0.08 ARG 186 -0.06 HIS 386

ALA 397 0.08 LEU 187 -0.06 HIS 386

ALA 397 0.07 LEU 188 -0.07 HIS 386

ALA 397 0.07 VAL 189 -0.07 HIS 386

ALA 397 0.07 LEU 190 -0.07 HIS 386

ALA 397 0.07 GLN 191 -0.07 HIS 386

ALA 397 0.07 PHE 192 -0.07 HIS 386

ALA 397 0.07 GLY 193 -0.06 HIS 386

ALA 397 0.06 GLY 194 -0.07 HIS 386

ALA 397 0.06 ALA 195 -0.07 GLU 60

ALA 397 0.08 SER 196 -0.06 HIS 386

ALA 397 0.08 GLY 197 -0.06 HIS 386

GLU 398 0.08 SER 198 -0.06 HIS 386

GLU 398 0.07 LEU 199 -0.06 HIS 386

GLU 398 0.07 ALA 200 -0.06 HIS 386

GLU 398 0.06 ALA 201 -0.07 GLU 60

GLU 398 0.06 LEU 202 -0.07 HIS 386

GLU 398 0.06 GLY 203 -0.06 HIS 386

GLU 398 0.06 SER 204 -0.06 HIS 386

GLU 398 0.06 LYS 205 -0.07 HIS 386

GLU 398 0.06 ALA 206 -0.06 HIS 386

GLU 398 0.07 MET 207 -0.06 HIS 386

GLU 398 0.06 PRO 208 -0.07 HIS 386

GLU 398 0.06 VAL 209 -0.07 HIS 386

GLU 398 0.06 ALA 210 -0.07 HIS 386

GLU 398 0.06 GLU 211 -0.07 HIS 386

GLU 398 0.06 ALA 212 -0.07 HIS 386

ALA 397 0.06 LEU 213 -0.07 HIS 386

ALA 397 0.06 ALA 214 -0.07 HIS 386

ALA 397 0.06 GLU 215 -0.07 HIS 386

ALA 397 0.06 GLN 216 -0.08 HIS 386

ALA 397 0.06 LEU 217 -0.08 HIS 386

ALA 397 0.06 LYS 218 -0.08 HIS 386

ALA 397 0.07 LEU 219 -0.07 HIS 386

ALA 397 0.07 THR 220 -0.06 HIS 386

ALA 397 0.07 LEU 221 -0.06 HIS 386

ALA 397 0.08 PRO 222 -0.06 HIS 386

ALA 397 0.09 GLU 223 -0.05 HIS 386

ALA 397 0.09 GLN 224 -0.05 HIS 386

ALA 397 0.08 PRO 225 -0.06 HIS 386

ALA 397 0.09 TRP 226 -0.06 HIS 386

ALA 397 0.08 HIS 227 -0.06 HIS 386

ALA 397 0.09 THR 228 -0.05 HIS 386

ALA 397 0.10 GLN 229 -0.05 HIS 386

ALA 397 0.09 ARG 230 -0.06 HIS 386

ALA 397 0.09 ASP 231 -0.05 HIS 386

ALA 397 0.09 ARG 232 -0.06 HIS 386

ALA 397 0.08 LEU 233 -0.06 HIS 386

ALA 397 0.09 VAL 234 -0.05 HIS 386

ALA 397 0.09 GLU 235 -0.05 HIS 386

ALA 397 0.08 PHE 236 -0.06 HIS 386

ALA 397 0.08 ALA 237 -0.06 HIS 386

ALA 397 0.08 SER 238 -0.05 HIS 386

ALA 397 0.08 VAL 239 -0.05 HIS 386

ALA 397 0.07 LEU 240 -0.06 HIS 386

ALA 397 0.08 GLY 241 -0.05 GLU 389

ALA 397 0.08 LEU 242 -0.05 GLU 389

ALA 397 0.07 VAL 243 -0.05 GLU 389

ALA 397 0.07 ALA 244 -0.06 GLU 389

ALA 397 0.07 GLY 245 -0.05 GLU 389

ALA 397 0.07 SER 246 -0.05 GLU 389

ALA 397 0.07 LEU 247 -0.05 GLU 389

ALA 397 0.07 GLY 248 -0.05 GLU 389

ALA 397 0.07 LYS 249 -0.04 GLU 389

ALA 397 0.07 PHE 250 -0.05 GLN 393

ALA 397 0.06 GLY 251 -0.06 GLU 389

ALA 397 0.06 ARG 252 -0.05 GLU 389

ALA 397 0.06 ASP 253 -0.04 GLN 393

ALA 397 0.06 ILE 254 -0.05 GLN 393

ALA 397 0.06 SER 255 -0.05 GLN 393

ALA 397 0.06 LEU 256 -0.04 GLN 393

ALA 397 0.06 LEU 257 -0.04 GLN 393

ALA 397 0.05 MET 258 -0.05 GLN 393

ALA 397 0.06 GLN 259 -0.04 GLU 60

ALA 397 0.05 THR 260 -0.04 GLU 60

ALA 397 0.06 GLU 261 -0.04 GLU 60

ALA 397 0.06 ALA 262 -0.04 GLU 60

ALA 397 0.05 GLY 263 -0.04 GLU 60

ALA 397 0.06 GLU 264 -0.04 ALA 397

ALA 397 0.06 VAL 265 -0.06 ALA 397

ALA 397 0.05 PHE 266 -0.08 GLN 393

ALA 397 0.05 GLU 267 -0.09 GLN 393

ALA 397 0.05 PRO 268 -0.11 GLN 393

ALA 397 0.04 SER 269 -0.14 GLN 393

ALA 397 0.04 ALA 270 -0.13 GLN 393

LYS 87 0.05 PRO 271 -0.14 GLN 390

ARG 98 0.06 MET 279 -0.14 CYS 392

ARG 98 0.05 PRO 280 -0.10 LEU 365

ARG 98 0.05 HIS 281 -0.11 GLN 393

ARG 98 0.05 LYS 282 -0.10 GLU 389

GLN 393 0.04 ARG 283 -0.10 GLN 393

ALA 397 0.04 ASN 284 -0.08 GLU 389

ALA 397 0.05 PRO 285 -0.07 GLU 389

ALA 74 0.07 VAL 286 -0.08 ALA 12

ALA 74 0.06 GLY 287 -0.11 GLN 340

ALA 397 0.05 ALA 288 -0.07 GLU 389

ALA 397 0.05 ALA 289 -0.07 GLU 389

ALA 397 0.05 VAL 290 -0.08 GLU 389

ALA 397 0.06 LEU 291 -0.07 GLU 389

ALA 397 0.06 ILE 292 -0.06 GLU 389

ALA 397 0.06 GLY 293 -0.06 GLU 389

ALA 397 0.06 ALA 294 -0.06 GLU 389

ALA 397 0.07 ALA 295 -0.05 GLU 389

ALA 397 0.07 THR 296 -0.05 GLU 389

ALA 397 0.06 ARG 297 -0.06 GLU 389

ALA 397 0.07 VAL 298 -0.06 GLU 389

ALA 397 0.08 PRO 299 -0.05 GLU 389

ALA 397 0.07 GLY 300 -0.05 GLU 389

ALA 397 0.07 LEU 301 -0.06 HIS 386

ALA 397 0.08 LEU 302 -0.05 HIS 386

ALA 397 0.08 SER 303 -0.05 HIS 386

ALA 397 0.08 THR 304 -0.05 HIS 386

ALA 397 0.08 LEU 305 -0.05 HIS 386

ALA 397 0.09 PHE 306 -0.05 HIS 386

ALA 397 0.09 ALA 307 -0.04 HIS 386

ALA 397 0.09 ALA 308 -0.05 HIS 386

ALA 397 0.10 MET 309 -0.05 HIS 386

ALA 397 0.11 PRO 310 -0.04 HIS 386

ALA 397 0.10 GLN 311 -0.05 HIS 386

ALA 397 0.10 GLU 312 -0.05 HIS 386

ALA 397 0.10 HIS 313 -0.05 HIS 386

ALA 397 0.09 GLU 314 -0.05 HIS 386

ALA 397 0.08 ARG 315 -0.06 HIS 386

ALA 397 0.08 SER 316 -0.05 HIS 386

ALA 397 0.07 LEU 317 -0.06 HIS 386

ALA 397 0.07 GLY 318 -0.06 HIS 386

ALA 397 0.08 LEU 319 -0.05 HIS 386

ALA 397 0.07 TRP 320 -0.06 HIS 386

ALA 397 0.06 HIS 321 -0.07 HIS 386

ALA 397 0.07 ALA 322 -0.06 HIS 386

ALA 397 0.07 GLU 323 -0.07 HIS 386

ALA 397 0.06 TRP 324 -0.07 HIS 386

ALA 397 0.06 GLU 325 -0.08 ASN 3

ALA 397 0.06 THR 326 -0.07 HIS 386

ALA 397 0.06 LEU 327 -0.07 HIS 386

ALA 397 0.06 PRO 328 -0.08 HIS 386

ALA 397 0.06 ASP 329 -0.08 HIS 386

ALA 397 0.06 ILE 330 -0.07 HIS 386

ALA 397 0.06 CYS 331 -0.07 HIS 386

ALA 397 0.06 CYS 332 -0.08 HIS 386

ALA 397 0.06 LEU 333 -0.08 GLU 389

ALA 397 0.06 VAL 334 -0.07 GLU 389

ALA 397 0.05 SER 335 -0.08 GLU 389

ALA 397 0.05 GLY 336 -0.09 GLU 389

ALA 397 0.06 ALA 337 -0.09 GLY 287

ALA 397 0.06 LEU 338 -0.07 GLU 389

ALA 397 0.05 ARG 339 -0.09 GLU 389

ALA 397 0.05 GLN 340 -0.11 GLY 287

ALA 397 0.06 ALA 341 -0.08 GLN 393

ALA 397 0.05 GLN 342 -0.08 GLN 393

ALA 397 0.05 VAL 343 -0.09 GLN 393

ALA 397 0.05 ILE 344 -0.08 GLN 393

ALA 397 0.06 ALA 345 -0.07 GLN 393

ALA 397 0.05 GLU 346 -0.08 ALA 397

ALA 397 0.05 GLY 347 -0.09 ALA 397

ALA 397 0.05 MET 348 -0.09 ALA 397

ALA 397 0.05 GLU 349 -0.10 ALA 397

ALA 397 0.06 VAL 350 -0.07 ALA 397

ALA 397 0.05 ASP 351 -0.05 ALA 397

ALA 397 0.06 ALA 352 -0.03 ALA 397

ALA 397 0.05 ALA 353 -0.03 GLY 92

ALA 397 0.06 ARG 354 -0.03 GLU 60

ALA 397 0.06 MET 355 -0.03 GLU 60

ALA 397 0.06 ARG 356 -0.03 GLU 60

ALA 397 0.06 ARG 357 -0.03 GLU 60

ALA 397 0.06 ASN 358 -0.03 GLU 60

ALA 397 0.06 LEU 359 -0.02 GLU 60

ALA 397 0.06 ASP 360 -0.03 GLU 60

ALA 397 0.06 LEU 361 -0.03 GLU 60

ALA 397 0.06 THR 362 -0.03 THR 260

ALA 397 0.06 GLN 363 -0.02 GLU 60

ALA 397 0.07 GLY 364 -0.02 GLU 349

ALA 397 0.07 LEU 365 -0.03 THR 278

ALA 397 0.07 VAL 366 -0.03 GLY 272

ALA 397 0.07 LEU 367 -0.02 THR 278

ALA 397 0.07 ALA 368 -0.03 THR 278

ALA 397 0.07 GLU 369 -0.03 LYS 282

ALA 397 0.07 ALA 370 -0.02 GLY 347

ALA 397 0.07 VAL 371 -0.03 THR 278

ALA 397 0.07 SER 372 -0.04 SER 277

ALA 397 0.08 ILE 373 -0.03 SER 277

ALA 397 0.07 VAL 374 -0.03 SER 277

ALA 397 0.07 LEU 375 -0.03 SER 277

ALA 397 0.08 ALA 376 -0.03 GLY 275

ALA 397 0.07 GLN 377 -0.03 GLY 275

ALA 397 0.07 ARG 378 -0.03 SER 277

ALA 397 0.07 LEU 379 -0.03 GLY 275

ALA 397 0.07 GLY 380 -0.04 GLY 275

ALA 397 0.08 ARG 381 -0.04 GLY 275

ALA 397 0.08 ASP 382 -0.05 GLY 275

ALA 397 0.07 ARG 383 -0.04 GLY 275

ALA 397 0.07 ALA 384 -0.04 SER 277

ALA 397 0.08 HIS 385 -0.05 SER 277

ALA 397 0.07 HIS 386 -0.05 GLY 275

ALA 397 0.07 LEU 387 -0.04 SER 277

ALA 397 0.07 LEU 388 -0.05 SER 277

ALA 397 0.07 GLU 389 -0.07 SER 277

ALA 397 0.07 GLN 390 -0.05 PRO 271

ALA 397 0.07 CYS 391 -0.04 PRO 271

ALA 397 0.07 CYS 392 -0.05 PRO 271

ALA 397 0.07 GLN 393 -0.06 PRO 271

ALA 397 0.07 ARG 394 -0.04 PRO 271

ALA 397 0.06 ALA 395 -0.03 GLU 349

ALA 397 0.06 VAL 396 -0.04 GLU 349

ALA 397 0.06 ALA 397 -0.04 GLU 349

ALA 397 0.06 GLU 398 -0.04 LYS 142

ALA 397 0.06 GLN 399 -0.04 ASP 351

ALA 397 0.06 ARG 400 -0.03 ASP 351

ALA 397 0.06 HIS 401 -0.03 GLU 349

ALA 397 0.06 LEU 402 -0.03 GLU 349

ALA 397 0.06 ARG 403 -0.02 GLU 349

ALA 397 0.06 ALA 404 -0.02 GLU 349

ALA 397 0.06 VAL 405 -0.03 GLU 349

ALA 397 0.06 LEU 406 -0.03 PRO 271

ALA 397 0.06 GLY 407 -0.02 GLU 349

ALA 397 0.06 ASP 408 -0.03 LYS 142

ALA 397 0.06 GLU 409 -0.03 PRO 271

ALA 397 0.06 PRO 410 -0.03 LYS 142

ALA 397 0.07 GLN 411 -0.03 PRO 271

ALA 397 0.07 VAL 412 -0.03 PRO 271

ALA 397 0.06 SER 413 -0.02 GLY 347

ALA 397 0.06 ALA 414 -0.03 GLY 347

ALA 397 0.07 GLU 415 -0.03 SER 277

ALA 397 0.06 LEU 416 -0.02 SER 277

ALA 397 0.06 SER 417 -0.02 GLY 347

ALA 397 0.06 GLY 418 -0.02 GLU 349

ALA 397 0.06 GLU 419 -0.02 GLY 347

ALA 397 0.06 GLU 420 -0.02 GLY 347

ALA 397 0.06 LEU 421 -0.02 PRO 271

ALA 397 0.06 ASP 422 -0.02 GLU 349

ALA 397 0.06 ARG 423 -0.02 GLY 347

ALA 397 0.07 LEU 424 -0.02 GLY 347

ALA 397 0.06 LEU 425 -0.02 GLU 349

ALA 397 0.06 ASP 426 -0.02 GLU 349

ALA 397 0.06 PRO 427 -0.02 GLU 60

ALA 397 0.06 ALA 428 -0.01 GLY 92

ALA 397 0.07 HIS 429 -0.01 GLY 347

ALA 397 0.07 TYR 430 -0.02 GLY 347

ALA 397 0.07 LEU 431 -0.02 GLY 203

ALA 397 0.07 GLY 432 -0.01 GLY 347

ALA 397 0.07 GLN 433 -0.02 GLN 393

ALA 397 0.07 ALA 434 -0.02 GLN 393

ALA 397 0.07 ARG 435 -0.02 GLN 393

ALA 397 0.07 VAL 436 -0.02 GLN 393

ALA 397 0.07 TRP 437 -0.03 GLN 393

ALA 397 0.07 VAL 438 -0.03 GLN 393

ALA 397 0.07 ALA 439 -0.03 GLN 393

ALA 397 0.07 ARG 440 -0.03 GLN 393

ALA 397 0.07 ALA 441 -0.03 GLN 393

ALA 397 0.07 VAL 442 -0.04 GLN 393

ALA 397 0.07 SER 443 -0.03 GLN 393

ALA 397 0.07 GLU 444 -0.04 GLN 393

ALA 397 0.07 HIS 445 -0.04 GLN 393

ALA 397 0.06 GLN 446 -0.04 GLN 393

ALA 397 0.07 ARG 447 -0.04 GLN 390

ALA 397 0.07 PHE 448 -0.04 GLN 390

ALA 397 0.06 THR 449 -0.05 GLN 390

ALA 397 0.06 ALA 450 -0.04 GLN 390

SER 20 0.06 ASN 3 -0.19 ASN 3

ALA 397 0.04 GLN 4 -0.15 ASN 3

ALA 397 0.04 LEU 5 -0.11 ASN 3

ALA 397 0.04 PHE 6 -0.09 ASN 3

ALA 397 0.03 ASP 7 -0.10 ASP 21

ALA 397 0.03 ALA 8 -0.11 ARG 16

GLN 340 0.03 TYR 9 -0.08 GLU 60

ALA 397 0.04 PHE 10 -0.07 VAL 286

ALA 397 0.03 THR 11 -0.10 ARG 16

CYS 332 0.04 ALA 12 -0.09 VAL 286

ALA 12 0.03 PRO 13 -0.10 ASN 69

ALA 12 0.03 ALA 14 -0.08 HIS 386

ALA 12 0.03 MET 15 -0.07 HIS 386

ALA 12 0.03 ARG 16 -0.11 ALA 8

ASN 3 0.03 GLU 17 -0.10 GLY 65

ASN 3 0.03 ILE 18 -0.10 GLY 23

ASN 3 0.04 PHE 19 -0.09 GLN 4

ASN 3 0.06 SER 20 -0.12 GLN 4

GLN 393 0.02 ASP 21 -0.14 GLN 4

GLN 393 0.02 ARG 22 -0.15 GLY 65

LEU 116 0.02 GLY 23 -0.12 GLY 65

GLN 393 0.03 ARG 24 -0.11 GLY 65

GLN 393 0.02 LEU 25 -0.11 GLY 65

LYS 218 0.02 GLN 26 -0.11 GLY 65

GLY 113 0.03 GLY 27 -0.10 GLY 65

GLN 393 0.03 MET 28 -0.09 GLY 65

ALA 59 0.04 LEU 29 -0.10 GLY 65

GLN 58 0.02 ASP 30 -0.10 GLY 65

GLN 393 0.03 PHE 31 -0.09 GLY 65

GLN 393 0.02 GLU 32 -0.09 GLY 65

LYS 218 0.02 ALA 33 -0.09 GLY 65

LYS 218 0.03 ALA 34 -0.08 GLY 65

LYS 218 0.03 LEU 35 -0.08 GLY 65

LYS 218 0.03 ALA 36 -0.08 GLY 65

LYS 218 0.03 ARG 37 -0.08 GLY 65

LYS 218 0.03 ALA 38 -0.07 GLY 65

ALA 55 0.03 GLU 39 -0.07 GLY 65

ALA 55 0.03 ALA 40 -0.07 GLY 65

ALA 55 0.03 SER 41 -0.07 GLY 65

ALA 55 0.03 ALA 42 -0.06 GLY 65

ALA 55 0.03 GLY 43 -0.07 THR 91

LEU 202 0.03 LEU 44 -0.07 GLU 60

MET 279 0.03 VAL 45 -0.08 ASP 63

MET 279 0.03 PRO 46 -0.08 THR 91

MET 279 0.03 HIS 47 -0.08 THR 91

MET 279 0.03 SER 48 -0.09 THR 91

MET 279 0.03 ALA 49 -0.09 THR 91

MET 279 0.03 VAL 50 -0.09 GLY 65

MET 279 0.03 ALA 51 -0.10 GLY 65

MET 279 0.03 ALA 52 -0.10 GLY 65

MET 279 0.03 ILE 53 -0.10 GLY 65

PRO 271 0.02 GLU 54 -0.11 GLY 65

PRO 271 0.03 ALA 55 -0.12 GLY 65

PRO 271 0.03 ALA 56 -0.12 GLY 65

PRO 271 0.03 CYS 57 -0.12 GLY 65

LEU 29 0.03 GLN 58 -0.13 GLY 65

LEU 29 0.04 ALA 59 -0.15 GLY 65

LEU 29 0.02 GLU 60 -0.16 GLY 65

PRO 271 0.03 ARG 61 -0.14 GLY 65

PRO 271 0.03 TYR 62 -0.14 ASP 63

PRO 271 0.03 ASP 63 -0.15 GLU 60

PRO 271 0.02 THR 64 -0.14 GLU 60

GLN 393 0.02 GLY 65 -0.15 GLU 60

PRO 271 0.02 ALA 66 -0.14 GLU 60

GLN 393 0.03 LEU 67 -0.12 GLU 60

GLN 393 0.03 ALA 68 -0.12 GLU 60

ALA 397 0.03 ASN 69 -0.12 HIS 386

GLN 393 0.03 ALA 70 -0.13 HIS 386

GLN 393 0.04 ILE 71 -0.12 HIS 386

ALA 397 0.04 ALA 72 -0.11 GLU 389

GLY 287 0.06 THR 73 -0.13 GLU 389

VAL 286 0.07 ALA 74 -0.14 GLU 389

GLY 287 0.06 GLY 75 -0.12 GLU 389

GLN 393 0.04 ASN 76 -0.11 GLU 389

GLN 393 0.03 SER 77 -0.10 HIS 386

GLN 393 0.03 ALA 78 -0.10 HIS 386

VAL 286 0.04 ILE 79 -0.12 HIS 386

ALA 270 0.03 PRO 80 -0.13 HIS 386

PRO 271 0.03 LEU 81 -0.11 ASP 382

VAL 286 0.03 VAL 82 -0.12 ASP 382

PRO 271 0.03 LYS 83 -0.15 ASP 382

PRO 271 0.04 ALA 84 -0.12 ASP 382

ALA 56 0.03 LEU 85 -0.11 GLU 60

SER 269 0.04 GLY 86 -0.13 ASP 382

PRO 271 0.05 LYS 87 -0.13 ASP 382

PRO 271 0.04 VAL 88 -0.13 GLU 60

MET 279 0.04 ILE 89 -0.11 ASP 63

MET 279 0.05 ALA 90 -0.11 GLU 60

PRO 271 0.04 THR 91 -0.12 GLU 60

MET 279 0.04 GLY 92 -0.12 THR 91

MET 279 0.04 VAL 93 -0.11 THR 91

MET 279 0.05 PRO 94 -0.11 THR 91

MET 279 0.05 GLU 95 -0.10 THR 91

MET 279 0.04 ALA 96 -0.10 ASP 63

MET 279 0.05 GLU 97 -0.11 GLY 380

MET 279 0.06 ARG 98 -0.14 GLY 380

LEU 102 0.05 TYR 99 -0.10 GLN 377

LEU 102 0.04 VAL 100 -0.09 GLY 380

GLY 194 0.03 HIS 101 -0.09 ALA 376

TYR 99 0.05 LEU 102 -0.10 ILE 373

GLY 194 0.05 GLY 103 -0.10 ILE 373

GLY 194 0.04 ALA 104 -0.08 ILE 373

GLN 393 0.04 THR 105 -0.08 ILE 373

GLN 393 0.04 SER 106 -0.08 GLU 389

GLN 393 0.04 GLN 107 -0.07 GLU 389

GLN 393 0.04 ASP 108 -0.07 GLY 65

GLN 393 0.03 ALA 109 -0.08 GLY 65

GLN 393 0.04 MET 110 -0.08 GLY 65

GLN 393 0.04 ASP 111 -0.06 GLY 65

GLN 393 0.04 THR 112 -0.06 GLY 65

GLN 393 0.03 GLY 113 -0.07 GLY 65

GLN 393 0.04 LEU 114 -0.07 GLY 65

GLN 393 0.04 VAL 115 -0.06 GLY 65

GLN 393 0.03 LEU 116 -0.07 GLY 65

GLN 393 0.03 GLN 117 -0.07 GLY 65

GLN 393 0.03 LEU 118 -0.06 HIS 386

GLN 393 0.03 ARG 119 -0.06 HIS 386

GLN 393 0.03 ASP 120 -0.06 HIS 386

GLN 393 0.03 ALA 121 -0.06 HIS 386

GLN 393 0.03 LEU 122 -0.05 HIS 386

GLN 393 0.03 ASP 123 -0.05 HIS 386

GLN 393 0.02 LEU 124 -0.06 GLN 393

GLN 393 0.03 ILE 125 -0.05 GLN 393

GLN 393 0.03 GLU 126 -0.05 GLN 393

ALA 450 0.02 ALA 127 -0.05 GLN 393

ALA 12 0.02 ASP 128 -0.07 GLN 342

GLN 393 0.03 LEU 129 -0.04 GLU 126

GLN 393 0.02 GLY 130 -0.05 GLU 419

ALA 12 0.02 LYS 131 -0.05 ALA 127

GLN 393 0.02 LEU 132 -0.05 ASP 128

GLN 393 0.02 ALA 133 -0.05 ALA 428

ALA 12 0.02 ASP 134 -0.06 GLU 419

THR 73 0.02 THR 135 -0.06 GLU 419

THR 73 0.02 LEU 136 -0.06 ALA 428

THR 73 0.02 SER 137 -0.07 ALA 428

THR 73 0.02 GLN 138 -0.07 GLU 419

GLU 349 0.02 GLN 139 -0.07 ALA 428

GLU 349 0.02 ALA 140 -0.08 ALA 428

ALA 439 0.02 LEU 141 -0.08 ALA 428

ALA 90 0.02 LYS 142 -0.09 GLU 419

GLY 163 0.02 HIS 143 -0.10 ALA 428

VAL 438 0.03 ALA 144 -0.12 ALA 428

ALA 90 0.02 ASP 145 -0.17 ALA 428

VAL 350 0.03 THR 146 -0.14 ALA 428

ARG 98 0.02 PRO 147 -0.10 ALA 428

ARG 98 0.02 LEU 148 -0.04 LEU 359

LEU 425 0.04 VAL 149 -0.03 HIS 386

VAL 366 0.08 GLY 150 -0.03 HIS 386

VAL 396 0.10 ARG 151 -0.03 HIS 386

VAL 396 0.12 THR 152 -0.03 ARG 98

VAL 396 0.14 TRP 153 -0.03 ARG 98

VAL 396 0.13 LEU 154 -0.03 HIS 386

VAL 396 0.16 GLN 155 -0.04 ARG 98

VAL 366 0.12 HIS 156 -0.04 ARG 98

VAL 366 0.14 ALA 157 -0.04 ARG 98

LEU 367 0.07 THR 158 -0.03 ARG 98

GLY 150 0.03 PRO 159 -0.03 TYR 430

GLN 393 0.02 VAL 160 -0.07 ALA 428

ARG 98 0.02 THR 161 -0.11 ALA 428

ALA 90 0.02 LEU 162 -0.08 ALA 428

HIS 143 0.02 GLY 163 -0.08 ALA 428

VAL 438 0.03 MET 164 -0.08 ALA 428

GLN 393 0.03 LYS 165 -0.06 ALA 428

GLN 393 0.03 LEU 166 -0.07 ALA 428

GLN 393 0.03 ALA 167 -0.07 ALA 428

GLN 393 0.04 GLY 168 -0.05 ALA 428

GLN 393 0.04 VAL 169 -0.05 ALA 428

GLN 393 0.03 LEU 170 -0.05 ALA 428

GLN 393 0.04 GLY 171 -0.05 ALA 428

GLN 393 0.05 ALA 172 -0.04 ALA 428

GLN 393 0.04 LEU 173 -0.04 ALA 428

GLN 393 0.04 THR 174 -0.05 ALA 428

GLN 393 0.05 ARG 175 -0.04 ALA 428

GLN 393 0.05 HIS 176 -0.04 ALA 428

GLN 393 0.04 ARG 177 -0.04 ALA 428

GLN 393 0.04 GLN 178 -0.04 GLU 419

GLN 393 0.05 ARG 179 -0.03 ALA 428

GLN 393 0.04 LEU 180 -0.04 GLN 393

GLN 393 0.04 GLN 181 -0.04 GLU 419

GLN 393 0.04 GLU 182 -0.04 GLN 178

GLN 393 0.05 LEU 183 -0.03 HIS 386

GLN 393 0.04 ARG 184 -0.04 HIS 386

LYS 218 0.04 PRO 185 -0.04 HIS 386

GLN 393 0.05 ARG 186 -0.04 HIS 386

GLN 393 0.04 LEU 187 -0.04 HIS 386

GLN 393 0.04 LEU 188 -0.05 HIS 386

GLN 393 0.04 VAL 189 -0.05 GLY 65

GLN 393 0.04 LEU 190 -0.05 GLY 65

GLN 393 0.04 GLN 191 -0.06 GLY 65

GLN 393 0.04 PHE 192 -0.06 GLY 65

GLN 393 0.04 GLY 193 -0.06 GLY 65

GLY 103 0.05 GLY 194 -0.06 GLU 60

GLN 393 0.04 ALA 195 -0.06 GLU 60

GLN 393 0.05 SER 196 -0.06 GLU 60

GLN 393 0.05 GLY 197 -0.05 GLU 60

GLN 393 0.05 SER 198 -0.05 GLU 60

GLN 393 0.04 LEU 199 -0.06 GLU 60

GLN 393 0.04 ALA 200 -0.06 GLU 60

GLN 393 0.04 ALA 201 -0.07 GLU 60

GLN 393 0.04 LEU 202 -0.06 GLU 60

ILE 373 0.04 GLY 203 -0.06 GLU 60

ALA 55 0.04 SER 204 -0.05 GLU 60

ALA 55 0.04 LYS 205 -0.06 GLU 60

ALA 55 0.04 ALA 206 -0.06 GLU 60

ALA 55 0.04 MET 207 -0.05 GLY 65

ALA 55 0.04 PRO 208 -0.05 GLY 65

LYS 218 0.03 VAL 209 -0.06 GLY 65

LYS 218 0.04 ALA 210 -0.06 GLY 65

LYS 218 0.04 GLU 211 -0.05 GLY 65

LYS 218 0.03 ALA 212 -0.06 GLY 65

LYS 218 0.03 LEU 213 -0.06 GLY 65

LYS 218 0.03 ALA 214 -0.06 GLY 65

LYS 218 0.03 GLU 215 -0.06 HIS 386

LYS 218 0.03 GLN 216 -0.07 GLY 65

LYS 218 0.03 LEU 217 -0.07 GLY 65

LYS 218 0.03 LYS 218 -0.06 HIS 386

LYS 218 0.04 LEU 219 -0.06 GLY 65

LYS 218 0.04 THR 220 -0.05 HIS 386

LYS 218 0.04 LEU 221 -0.05 GLY 65

GLN 393 0.05 PRO 222 -0.04 GLY 65

GLN 393 0.05 GLU 223 -0.04 GLY 65

GLN 393 0.05 GLN 224 -0.04 GLY 65

GLN 393 0.05 PRO 225 -0.05 GLY 65

GLN 393 0.05 TRP 226 -0.05 GLY 65

GLN 393 0.05 HIS 227 -0.05 GLU 60

GLN 393 0.06 THR 228 -0.04 GLU 60

GLN 393 0.06 GLN 229 -0.04 GLY 65

GLN 393 0.06 ARG 230 -0.04 ASN 3

GLN 393 0.06 ASP 231 -0.03 HIS 386

GLN 393 0.05 ARG 232 -0.04 HIS 386

GLN 393 0.05 LEU 233 -0.04 HIS 386

GLN 393 0.06 VAL 234 -0.04 GLU 389

GLN 393 0.06 GLU 235 -0.03 VAL 286

GLN 393 0.05 PHE 236 -0.04 VAL 286

GLN 393 0.05 ALA 237 -0.04 GLU 389

GLN 393 0.06 SER 238 -0.04 GLU 389

GLN 393 0.06 VAL 239 -0.03 HIS 386

GLN 393 0.05 LEU 240 -0.04 VAL 286

GLN 393 0.06 GLY 241 -0.04 HIS 386

GLN 393 0.06 LEU 242 -0.03 HIS 386

GLN 393 0.05 VAL 243 -0.04 HIS 386

GLN 393 0.05 ALA 244 -0.05 VAL 286

GLN 393 0.06 GLY 245 -0.04 HIS 386

GLN 393 0.06 SER 246 -0.04 HIS 386

GLN 393 0.05 LEU 247 -0.04 HIS 386

ALA 397 0.06 GLY 248 -0.04 HIS 386

GLN 393 0.06 LYS 249 -0.04 HIS 386

GLN 393 0.05 PHE 250 -0.04 HIS 386

VAL 396 0.05 GLY 251 -0.05 HIS 386

VAL 396 0.06 ARG 252 -0.04 HIS 386

VAL 396 0.06 ASP 253 -0.04 HIS 386

VAL 396 0.04 ILE 254 -0.04 HIS 386

VAL 396 0.05 SER 255 -0.05 HIS 386

VAL 396 0.06 LEU 256 -0.04 HIS 386

VAL 396 0.04 LEU 257 -0.04 HIS 386

VAL 396 0.04 MET 258 -0.05 GLU 60

VAL 396 0.05 GLN 259 -0.05 GLU 60

GLN 399 0.05 THR 260 -0.05 GLU 60

GLN 399 0.06 GLU 261 -0.04 GLU 60

THR 362 0.04 ALA 262 -0.04 GLU 60

ARG 283 0.03 GLY 263 -0.05 GLU 60

ARG 98 0.02 GLU 264 -0.04 HIS 386

ALA 90 0.02 VAL 265 -0.05 ALA 55

ALA 90 0.02 PHE 266 -0.06 ALA 397

VAL 286 0.03 GLU 267 -0.06 ALA 397

VAL 286 0.03 PRO 268 -0.08 ALA 397

VAL 286 0.04 SER 269 -0.09 GLN 393

THR 362 0.03 THR 278 -0.11 GLU 389

THR 362 0.03 MET 279 -0.10 GLU 389

LEU 361 0.03 PRO 280 -0.09 GLN 393

LEU 361 0.04 HIS 281 -0.07 GLU 60

VAL 396 0.04 LYS 282 -0.08 GLU 60

VAL 396 0.04 ARG 283 -0.07 GLU 60

ALA 397 0.04 ASN 284 -0.07 GLU 60

ALA 397 0.04 PRO 285 -0.08 GLY 287

ALA 74 0.07 VAL 286 -0.10 GLY 287

GLY 75 0.04 GLY 287 -0.10 VAL 286

ALA 397 0.04 ALA 288 -0.07 PRO 285

ALA 397 0.05 ALA 289 -0.08 VAL 286

ALA 397 0.05 VAL 290 -0.08 VAL 286

ALA 397 0.05 LEU 291 -0.05 VAL 286

ALA 397 0.06 ILE 292 -0.05 HIS 386

ALA 397 0.06 GLY 293 -0.06 HIS 386

ALA 397 0.06 ALA 294 -0.06 HIS 386

ALA 397 0.06 ALA 295 -0.05 HIS 386

ALA 397 0.07 THR 296 -0.05 HIS 386

ALA 397 0.06 ARG 297 -0.05 HIS 386

ALA 397 0.06 VAL 298 -0.05 HIS 386

ALA 397 0.07 PRO 299 -0.04 HIS 386

ALA 397 0.07 GLY 300 -0.05 HIS 386

ALA 397 0.06 LEU 301 -0.05 HIS 386

GLN 393 0.06 LEU 302 -0.04 GLU 389

ALA 397 0.07 SER 303 -0.04 GLU 389

ALA 397 0.07 THR 304 -0.05 GLU 389

GLN 393 0.06 LEU 305 -0.04 GLU 389

GLN 393 0.07 PHE 306 -0.04 GLU 389

ALA 397 0.07 ALA 307 -0.04 GLU 389

GLN 393 0.06 ALA 308 -0.04 GLU 389

GLN 393 0.07 MET 309 -0.04 GLU 389

GLN 393 0.07 PRO 310 -0.03 ASN 3

GLN 393 0.06 GLN 311 -0.04 GLU 60

GLN 393 0.06 GLU 312 -0.04 GLU 60

GLN 393 0.06 HIS 313 -0.04 GLU 60

GLN 393 0.06 GLU 314 -0.05 GLU 60

GLN 393 0.05 ARG 315 -0.05 GLU 389

GLN 393 0.06 SER 316 -0.05 GLU 389

ALA 397 0.05 LEU 317 -0.06 GLU 389

ALA 397 0.06 GLY 318 -0.06 GLU 389

ALA 397 0.06 LEU 319 -0.05 GLU 389

GLN 393 0.05 TRP 320 -0.06 GLU 389

ALA 397 0.05 HIS 321 -0.07 GLU 389

ALA 397 0.05 ALA 322 -0.06 GLU 389

GLN 393 0.05 GLU 323 -0.06 GLU 389

GLN 393 0.05 TRP 324 -0.07 GLU 389

ALA 397 0.04 GLU 325 -0.07 ASN 3

ALA 397 0.05 THR 326 -0.06 HIS 386

GLN 393 0.05 LEU 327 -0.06 HIS 386

GLN 393 0.04 PRO 328 -0.06 HIS 386

ALA 397 0.04 ASP 329 -0.06 VAL 286

GLN 393 0.05 ILE 330 -0.05 VAL 286

GLN 393 0.04 CYS 331 -0.06 CYS 332

ALA 12 0.04 CYS 332 -0.06 HIS 386

ALA 397 0.04 LEU 333 -0.07 VAL 286

GLN 393 0.04 VAL 334 -0.06 VAL 286

GLN 393 0.03 SER 335 -0.06 VAL 286

GLN 393 0.03 GLY 336 -0.08 VAL 286

GLN 393 0.03 ALA 337 -0.07 VAL 286

GLN 393 0.03 LEU 338 -0.05 VAL 286

GLN 393 0.02 ARG 339 -0.07 ALA 12

TYR 9 0.03 GLN 340 -0.07 VAL 286

GLN 393 0.03 ALA 341 -0.05 ASP 382

THR 73 0.03 GLN 342 -0.07 ASP 128

THR 73 0.03 VAL 343 -0.06 ALA 12

THR 73 0.03 ILE 344 -0.06 ALA 397

THR 73 0.02 ALA 345 -0.05 ALA 397

THR 73 0.02 GLU 346 -0.06 ALA 397

THR 73 0.02 GLY 347 -0.07 ALA 397

ALA 74 0.02 MET 348 -0.06 ALA 397

VAL 286 0.02 GLU 349 -0.07 VAL 350

THR 146 0.03 VAL 350 -0.07 GLU 349

ARG 98 0.02 ASP 351 -0.06 GLU 349

ARG 98 0.02 ALA 352 -0.05 ARG 403

PRO 280 0.03 ALA 353 -0.06 HIS 401

PRO 280 0.03 ARG 354 -0.04 ALA 55

PRO 280 0.02 MET 355 -0.04 ALA 55

ALA 428 0.03 ARG 356 -0.07 ASP 360

ASP 426 0.04 ARG 357 -0.06 ASP 360

ASP 422 0.04 ASN 358 -0.04 ALA 55

ASP 426 0.06 LEU 359 -0.04 LEU 148

THR 260 0.07 ASP 360 -0.07 ARG 356

THR 260 0.12 LEU 361 -0.05 ARG 357

THR 260 0.17 THR 362 -0.03 ARG 357

LYS 282 0.13 GLN 363 -0.05 ARG 357

LYS 282 0.14 GLY 364 -0.05 THR 146

LYS 282 0.21 LEU 365 -0.03 THR 146

ALA 157 0.14 VAL 366 -0.04 GLU 369

LYS 282 0.11 LEU 367 -0.04 THR 146

LYS 282 0.15 ALA 368 -0.04 THR 146

THR 105 0.11 GLU 369 -0.04 VAL 366

LYS 282 0.07 ALA 370 -0.07 GLY 203

LYS 282 0.10 VAL 371 -0.06 SER 204

ILE 79 0.10 SER 372 -0.05 GLY 203

LYS 83 0.07 ILE 373 -0.06 GLY 203

LYS 83 0.07 VAL 374 -0.09 SER 204

LYS 83 0.10 LEU 375 -0.06 SER 204

ARG 98 0.10 ALA 376 -0.06 GLY 43

ARG 98 0.08 GLN 377 -0.09 GLY 43

LYS 83 0.08 ARG 378 -0.08 SER 204

LYS 83 0.10 LEU 379 -0.06 GLY 43

ARG 98 0.14 GLY 380 -0.05 GLY 43

ARG 98 0.17 ARG 381 -0.03 GLY 43

ARG 98 0.20 ASP 382 -0.02 GLY 43

LYS 83 0.17 ARG 383 -0.03 SER 204

LYS 83 0.15 ALA 384 -0.03 SER 204

LYS 83 0.20 HIS 385 -0.02 LEU 365

LYS 83 0.22 HIS 386 -0.02 ARG 383

LYS 83 0.17 LEU 387 -0.03 ASP 145

LYS 83 0.16 LEU 388 -0.03 THR 146

ALA 74 0.21 GLU 389 -0.02 ARG 357

ALA 270 0.22 GLN 390 -0.03 ALA 353

LYS 282 0.20 CYS 391 -0.04 THR 146

LYS 282 0.27 CYS 392 -0.03 ARG 357

SER 269 0.28 GLN 393 -0.03 ARG 357

SER 269 0.25 ARG 394 -0.04 ALA 353

LYS 282 0.23 ALA 395 -0.04 ALA 353

ARG 283 0.29 VAL 396 -0.04 ARG 357

SER 269 0.30 ALA 397 -0.04 ARG 357

SER 269 0.25 GLU 398 -0.05 ALA 353

ASP 351 0.24 GLN 399 -0.05 ARG 357

ASP 351 0.19 ARG 400 -0.06 ALA 353

LYS 282 0.17 HIS 401 -0.07 ARG 356

LYS 282 0.18 LEU 402 -0.06 THR 146

LYS 282 0.14 ARG 403 -0.08 THR 146

LYS 282 0.15 ALA 404 -0.07 THR 146

LYS 282 0.17 VAL 405 -0.05 THR 146

LYS 282 0.15 LEU 406 -0.06 ASP 145

SER 269 0.13 GLY 407 -0.07 ASP 422

SER 269 0.15 ASP 408 -0.06 ASP 145

SER 269 0.15 GLU 409 -0.05 ASP 145

SER 269 0.13 PRO 410 -0.05 ASP 145

ALA 270 0.12 GLN 411 -0.05 SER 204

ALA 270 0.11 VAL 412 -0.06 SER 204

SER 269 0.11 SER 413 -0.06 SER 204

SER 269 0.10 ALA 414 -0.06 SER 204

SER 269 0.09 GLU 415 -0.07 SER 204

LYS 282 0.09 LEU 416 -0.08 SER 204

LYS 282 0.09 SER 417 -0.07 SER 204

ALA 353 0.10 GLY 418 -0.08 ASP 145

ALA 353 0.09 GLU 419 -0.09 ASP 145

LYS 282 0.08 GLU 420 -0.09 ASP 145

LYS 282 0.10 LEU 421 -0.08 ASP 145

LYS 282 0.09 ASP 422 -0.08 ASP 145

LYS 282 0.07 ARG 423 -0.10 ASP 145

LYS 282 0.09 LEU 424 -0.08 ASP 145

LYS 282 0.11 LEU 425 -0.07 ARG 403

LYS 282 0.07 ASP 426 -0.10 ASP 145

LYS 282 0.05 PRO 427 -0.08 ASP 145

ARG 357 0.03 ALA 428 -0.17 ASP 145

LYS 282 0.04 HIS 429 -0.13 ASP 145

LYS 282 0.02 TYR 430 -0.14 LEU 431

ARG 98 0.02 LEU 431 -0.14 TYR 430

ARG 98 0.01 GLY 432 -0.08 HIS 429

GLU 389 0.02 GLN 433 -0.08 HIS 429

PRO 147 0.02 ALA 434 -0.09 HIS 429

ASP 145 0.02 ARG 435 -0.10 HIS 429

ARG 98 0.01 VAL 436 -0.08 HIS 429

GLU 389 0.03 TRP 437 -0.06 HIS 429

MET 164 0.03 VAL 438 -0.07 HIS 429

ALA 144 0.02 ALA 439 -0.07 GLU 419

GLU 389 0.02 ARG 440 -0.06 GLU 419

GLN 393 0.03 ALA 441 -0.06 HIS 429

GLN 393 0.02 VAL 442 -0.07 GLU 419

SER 41 0.02 SER 443 -0.07 GLU 419

GLU 389 0.03 GLU 444 -0.06 GLU 419

GLN 393 0.02 HIS 445 -0.06 GLU 419

SER 41 0.02 GLN 446 -0.07 GLU 419

SER 41 0.02 ARG 447 -0.06 GLU 419

GLN 393 0.03 PHE 448 -0.05 GLU 419

GLN 393 0.02 THR 449 -0.06 GLU 419

ALA 127 0.02 ALA 450 -0.06 GLU 419

ALA 397 0.12 ASN 3 -0.04 SER 20

GLN 393 0.11 GLN 4 -0.04 ARG 16

ALA 397 0.10 LEU 5 -0.03 ARG 16

GLN 393 0.10 PHE 6 -0.03 ALA 121

GLN 393 0.10 ASP 7 -0.03 ALA 12

GLN 393 0.10 ALA 8 -0.04 ALA 68

GLN 393 0.09 TYR 9 -0.03 ALA 121

GLN 393 0.09 PHE 10 -0.03 ALA 121

GLN 393 0.10 THR 11 -0.04 SER 335

GLN 393 0.09 ALA 12 -0.05 GLY 65

GLN 393 0.09 PRO 13 -0.07 GLY 65

GLN 393 0.09 ALA 14 -0.05 GLY 65

GLN 393 0.09 MET 15 -0.05 GLY 65

GLN 393 0.10 ARG 16 -0.05 GLY 65

GLN 393 0.10 GLU 17 -0.06 GLY 65

GLN 393 0.10 ILE 18 -0.04 GLY 65

GLN 393 0.11 PHE 19 -0.04 GLY 65

GLN 393 0.12 SER 20 -0.04 GLY 65

GLN 393 0.13 ASP 21 -0.04 SER 20

HIS 386 0.12 ARG 22 -0.04 ARG 22

HIS 386 0.11 GLY 23 -0.03 GLY 65

GLN 393 0.12 ARG 24 -0.03 ASP 21

HIS 386 0.13 LEU 25 -0.03 SER 20

HIS 386 0.11 GLN 26 -0.03 GLU 60

HIS 386 0.10 GLY 27 -0.03 LEU 217

HIS 386 0.12 MET 28 -0.02 SER 20

HIS 386 0.12 LEU 29 -0.03 ASP 30

HIS 386 0.10 ASP 30 -0.03 LEU 29

HIS 386 0.10 PHE 31 -0.02 GLU 60

HIS 386 0.11 GLU 32 -0.02 PRO 13

HIS 386 0.09 ALA 33 -0.02 GLU 60

HIS 386 0.07 ALA 34 -0.02 GLU 60

HIS 385 0.08 LEU 35 -0.02 GLU 60

ASP 382 0.07 ALA 36 -0.02 GLU 60

ALA 450 0.06 ARG 37 -0.02 GLU 60

ALA 450 0.06 ALA 38 -0.03 GLN 377

ALA 450 0.05 GLU 39 -0.03 GLN 377

ALA 450 0.05 ALA 40 -0.04 GLN 377

ALA 450 0.06 SER 41 -0.05 GLN 377

ALA 450 0.04 ALA 42 -0.07 GLN 377

ALA 450 0.04 GLY 43 -0.09 GLN 377

ALA 450 0.04 LEU 44 -0.06 GLN 377

ALA 450 0.05 VAL 45 -0.03 GLN 377

ALA 450 0.05 PRO 46 -0.04 GLN 377

ALA 450 0.06 HIS 47 -0.03 GLN 377

ALA 450 0.06 SER 48 -0.03 PRO 271

ALA 450 0.06 ALA 49 -0.03 ALA 270

ALA 450 0.07 VAL 50 -0.02 LYS 83

ALA 450 0.07 ALA 51 -0.02 LYS 83

ASP 382 0.08 ALA 52 -0.03 LYS 83

ASP 382 0.09 ILE 53 -0.03 LYS 83

HIS 386 0.08 GLU 54 -0.02 LYS 83

HIS 386 0.08 ALA 55 -0.03 LYS 83

HIS 386 0.11 ALA 56 -0.03 LEU 85

HIS 386 0.11 CYS 57 -0.02 GLU 60

HIS 386 0.11 GLN 58 -0.03 GLU 60

HIS 386 0.12 ALA 59 -0.03 GLU 60

HIS 386 0.12 GLU 60 -0.03 GLU 60

HIS 386 0.13 ARG 61 -0.03 PRO 13

HIS 386 0.14 TYR 62 -0.03 PRO 13

HIS 386 0.15 ASP 63 -0.04 PRO 13

HIS 386 0.14 THR 64 -0.05 PRO 13

GLN 393 0.15 GLY 65 -0.06 PRO 13

GLN 393 0.17 ALA 66 -0.04 PRO 13

GLN 393 0.17 LEU 67 -0.03 PRO 13

GLN 393 0.17 ALA 68 -0.04 PRO 13

GLN 393 0.18 ASN 69 -0.03 ALA 12

GLN 393 0.20 ALA 70 -0.03 ALA 84

GLN 393 0.19 ILE 71 -0.02 GLY 86

GLN 393 0.19 ALA 72 -0.03 GLN 340

GLN 393 0.23 THR 73 -0.03 GLN 340

GLN 393 0.22 ALA 74 -0.03 GLY 86

GLN 393 0.20 GLY 75 -0.05 VAL 290

GLN 393 0.18 ASN 76 -0.03 VAL 290

GLN 393 0.16 SER 77 -0.02 PRO 13

GLU 389 0.16 ALA 78 -0.02 ASP 120

GLU 389 0.20 ILE 79 -0.03 GLY 86

GLU 389 0.19 PRO 80 -0.03 GLY 86

HIS 386 0.17 LEU 81 -0.02 PRO 13

HIS 386 0.18 VAL 82 -0.03 ILE 53

HIS 386 0.22 LYS 83 -0.07 GLY 86

HIS 386 0.19 ALA 84 -0.03 ALA 70

HIS 386 0.16 LEU 85 -0.03 ALA 56

ASP 382 0.18 GLY 86 -0.07 LYS 83

HIS 386 0.18 LYS 87 -0.04 LYS 83

HIS 386 0.14 VAL 88 -0.03 LYS 83

ASP 382 0.13 ILE 89 -0.03 LYS 83

ASP 382 0.15 ALA 90 -0.04 PRO 271

ASP 382 0.11 THR 91 -0.03 PRO 271

ASP 382 0.08 GLY 92 -0.03 PRO 271

ASP 382 0.08 VAL 93 -0.03 PRO 271

ASP 382 0.12 PRO 94 -0.04 ALA 270

ASP 382 0.09 GLU 95 -0.04 LYS 282

ASP 382 0.10 ALA 96 -0.03 LYS 282

ASP 382 0.17 GLU 97 -0.04 ALA 270

ASP 382 0.20 ARG 98 -0.04 LYS 282

ASP 382 0.12 TYR 99 -0.03 LYS 282

ASP 382 0.13 VAL 100 -0.02 ALA 270

HIS 385 0.14 HIS 101 -0.02 VAL 286

HIS 385 0.12 LEU 102 -0.03 TYR 99

HIS 385 0.09 GLY 103 -0.03 ALA 195

GLU 389 0.11 ALA 104 -0.02 GLY 194

GLU 389 0.14 THR 105 -0.02 ARG 315

GLU 389 0.16 SER 106 -0.02 VAL 290

GLU 389 0.13 GLN 107 -0.02 HIS 386

GLU 389 0.11 ASP 108 -0.02 PHE 192

GLU 389 0.12 ALA 109 -0.02 LEU 213

GLU 389 0.12 MET 110 -0.02 SER 20

GLU 389 0.11 ASP 111 -0.02 GLY 65

GLU 389 0.10 THR 112 -0.03 GLY 65

GLU 389 0.11 GLY 113 -0.03 GLY 65

GLN 393 0.11 LEU 114 -0.03 GLY 65

GLU 389 0.09 VAL 115 -0.03 GLY 65

GLU 389 0.09 LEU 116 -0.04 GLY 65

GLN 393 0.10 GLN 117 -0.04 GLY 65

GLN 393 0.09 LEU 118 -0.04 GLY 65

GLN 393 0.08 ARG 119 -0.04 GLY 65

HIS 386 0.09 ASP 120 -0.04 GLY 65

GLN 393 0.09 ALA 121 -0.04 THR 11

GLN 393 0.08 LEU 122 -0.03 GLY 65

GLN 393 0.08 ASP 123 -0.04 GLY 65

GLN 393 0.08 LEU 124 -0.04 GLY 65

GLN 393 0.08 ILE 125 -0.03 ASN 69

GLN 393 0.07 GLU 126 -0.03 LEU 180

GLY 130 0.09 ALA 127 -0.03 LYS 87

LYS 131 0.08 ASP 128 -0.03 ASP 382

GLN 393 0.08 LEU 129 -0.03 HIS 386

ALA 127 0.09 GLY 130 -0.03 HIS 386

ASP 128 0.08 LYS 131 -0.03 HIS 386

GLN 393 0.07 LEU 132 -0.03 HIS 386

GLN 393 0.07 ALA 133 -0.03 HIS 386

GLN 393 0.07 ASP 134 -0.03 HIS 386

GLN 393 0.07 THR 135 -0.04 HIS 386

GLN 393 0.07 LEU 136 -0.03 GLN 393

GLN 393 0.06 SER 137 -0.03 GLN 393

GLN 393 0.06 GLN 138 -0.04 ALA 397

GLN 393 0.07 GLN 139 -0.04 ALA 397

GLN 393 0.06 ALA 140 -0.04 ALA 397

ARG 423 0.06 LEU 141 -0.04 ALA 397

GLU 419 0.07 LYS 142 -0.04 ALA 397

ARG 423 0.07 HIS 143 -0.04 ALA 397

ALA 428 0.07 ALA 144 -0.04 GLU 60

ALA 428 0.11 ASP 145 -0.04 GLU 60

ALA 428 0.10 THR 146 -0.04 GLU 60

ARG 423 0.07 PRO 147 -0.04 GLU 60

GLN 393 0.06 LEU 148 -0.04 GLU 60

GLN 393 0.05 VAL 149 -0.05 GLU 60

GLN 393 0.05 GLY 150 -0.05 GLU 60

GLN 393 0.05 ARG 151 -0.05 GLU 60

GLN 393 0.05 THR 152 -0.05 GLU 60

GLN 393 0.05 TRP 153 -0.06 GLU 389

GLN 393 0.06 LEU 154 -0.05 GLU 60

GLN 393 0.05 GLN 155 -0.05 GLU 60

GLN 393 0.05 HIS 156 -0.05 GLU 60

GLN 393 0.05 ALA 157 -0.06 GLU 60

GLN 393 0.05 THR 158 -0.06 GLU 60

GLN 393 0.05 PRO 159 -0.05 GLU 60

GLN 393 0.05 VAL 160 -0.05 GLU 60

GLN 393 0.06 THR 161 -0.04 GLU 60

GLN 393 0.06 LEU 162 -0.04 GLU 60

GLN 393 0.06 GLY 163 -0.04 GLU 60

GLN 393 0.06 MET 164 -0.04 GLU 60

GLN 393 0.06 LYS 165 -0.04 GLU 60

GLN 393 0.06 LEU 166 -0.03 GLU 60

GLN 393 0.06 ALA 167 -0.04 GLU 60

GLN 393 0.06 GLY 168 -0.04 GLY 65

GLN 393 0.06 VAL 169 -0.03 GLU 60

GLN 393 0.06 LEU 170 -0.03 GLY 65

GLN 393 0.06 GLY 171 -0.03 GLY 65

GLN 393 0.06 ALA 172 -0.03 GLY 65

GLN 393 0.07 LEU 173 -0.03 GLY 65

GLN 393 0.06 THR 174 -0.03 GLU 182

GLN 393 0.06 ARG 175 -0.04 GLU 182

GLN 393 0.07 HIS 176 -0.03 GLU 182

GLN 393 0.07 ARG 177 -0.03 GLU 182

GLN 393 0.06 GLN 178 -0.04 GLU 182

GLN 393 0.06 ARG 179 -0.03 GLU 182

GLN 393 0.07 LEU 180 -0.03 LEU 338

ARG 184 0.07 GLN 181 -0.03 GLU 126

GLN 393 0.06 GLU 182 -0.03 PHE 448

GLN 393 0.06 LEU 183 -0.03 GLY 65

GLN 181 0.07 ARG 184 -0.03 GLY 65

LYS 218 0.06 PRO 185 -0.03 HIS 429

GLN 393 0.06 ARG 186 -0.03 HIS 429

GLN 393 0.07 LEU 187 -0.03 GLY 65

GLU 389 0.07 LEU 188 -0.03 GLY 65

GLU 389 0.07 VAL 189 -0.03 GLY 65

GLU 389 0.08 LEU 190 -0.03 GLY 65

GLU 389 0.09 GLN 191 -0.02 GLY 65

GLU 389 0.08 PHE 192 -0.02 HIS 429

GLU 389 0.07 GLY 193 -0.02 HIS 429

GLU 389 0.09 GLY 194 -0.03 GLY 103

GLU 389 0.11 ALA 195 -0.03 ARG 98

GLU 389 0.08 SER 196 -0.02 ARG 98

GLU 389 0.06 GLY 197 -0.03 HIS 429

GLU 389 0.04 SER 198 -0.05 HIS 429

GLU 389 0.05 LEU 199 -0.03 HIS 429

GLU 389 0.02 ALA 200 -0.03 LEU 44

GLU 389 0.03 ALA 201 -0.03 THR 158

ALA 450 0.03 LEU 202 -0.03 GLN 377

ALA 450 0.02 GLY 203 -0.08 VAL 374

ALA 450 0.02 SER 204 -0.09 VAL 374

ALA 450 0.03 LYS 205 -0.07 GLN 377

ALA 450 0.02 ALA 206 -0.05 GLU 420

ALA 450 0.02 MET 207 -0.05 GLU 420

ALA 450 0.03 PRO 208 -0.05 GLU 420

ALA 450 0.04 VAL 209 -0.03 GLU 420

GLU 389 0.04 ALA 210 -0.03 GLU 420

ALA 450 0.04 GLU 211 -0.04 GLU 420

ALA 450 0.05 ALA 212 -0.03 GLU 420

GLU 389 0.05 LEU 213 -0.02 GLY 65

GLU 389 0.05 ALA 214 -0.03 GLY 65

ALA 450 0.06 GLU 215 -0.03 GLY 65

ALA 450 0.07 GLN 216 -0.03 GLY 65

ALA 450 0.07 LEU 217 -0.03 GLY 65

ALA 450 0.08 LYS 218 -0.04 GLY 65

GLU 389 0.06 LEU 219 -0.03 GLY 65

GLU 389 0.05 THR 220 -0.03 GLY 65

GLU 389 0.05 LEU 221 -0.03 HIS 429

GLU 389 0.05 PRO 222 -0.04 HIS 429

GLU 389 0.04 GLU 223 -0.05 HIS 429

GLU 389 0.05 GLN 224 -0.05 HIS 429

GLU 389 0.06 PRO 225 -0.03 HIS 429

GLN 393 0.07 TRP 226 -0.03 ALA 428

GLN 393 0.09 HIS 227 -0.02 HIS 386

GLN 393 0.08 THR 228 -0.03 HIS 386

GLN 393 0.07 GLN 229 -0.03 ALA 428

GLN 393 0.08 ARG 230 -0.03 HIS 386

GLN 393 0.07 ASP 231 -0.03 ALA 428

GLN 393 0.07 ARG 232 -0.03 ALA 428

GLN 393 0.08 LEU 233 -0.02 GLY 65

GLN 393 0.08 VAL 234 -0.02 GLU 389

GLN 393 0.07 GLU 235 -0.02 ALA 428

GLN 393 0.08 PHE 236 -0.03 GLY 65

GLN 393 0.08 ALA 237 -0.02 VAL 334

GLN 393 0.07 SER 238 -0.03 VAL 286

GLN 393 0.07 VAL 239 -0.02 VAL 286

GLN 393 0.08 LEU 240 -0.02 VAL 334

GLN 393 0.08 GLY 241 -0.02 VAL 286

GLN 393 0.07 LEU 242 -0.03 VAL 286

GLN 393 0.07 VAL 243 -0.02 VAL 286

GLN 393 0.08 ALA 244 -0.02 ASN 3

GLN 393 0.07 GLY 245 -0.03 ASN 3

GLN 393 0.07 SER 246 -0.03 ASN 3

GLN 393 0.07 LEU 247 -0.03 ASN 3

GLN 393 0.07 GLY 248 -0.03 ASN 3

GLN 393 0.07 LYS 249 -0.03 ASN 3

GLN 393 0.07 PHE 250 -0.03 GLU 60

GLN 393 0.07 GLY 251 -0.03 GLU 60

GLN 393 0.07 ARG 252 -0.03 GLU 60

GLN 393 0.07 ASP 253 -0.03 GLU 60

GLN 393 0.07 ILE 254 -0.03 SER 255

GLN 393 0.07 SER 255 -0.03 ILE 254

GLN 393 0.07 LEU 256 -0.03 GLU 60

GLN 393 0.06 LEU 257 -0.03 GLU 60

GLN 393 0.07 MET 258 -0.03 GLU 60

ALA 397 0.07 GLN 259 -0.03 GLU 60

ALA 397 0.07 THR 260 -0.03 GLU 60

ALA 397 0.06 GLU 261 -0.03 GLU 60

GLN 393 0.06 ALA 262 -0.04 GLU 60

GLN 393 0.06 GLY 263 -0.04 VAL 396

GLN 393 0.06 GLU 264 -0.04 VAL 396

GLN 393 0.07 VAL 265 -0.03 VAL 396

GLN 393 0.07 PHE 266 -0.03 GLN 393

GLN 393 0.08 GLU 267 -0.03 HIS 386

GLN 393 0.08 PRO 268 -0.05 GLY 347

GLN 393 0.08 SER 269 -0.04 HIS 386

GLN 393 0.07 ALA 270 -0.05 GLU 389

GLN 393 0.07 PRO 271 -0.06 GLN 393

GLN 393 0.07 GLY 272 -0.04 GLU 389

ALA 397 0.08 LYS 273 -0.03 SER 269

ALA 397 0.08 GLY 274 -0.04 HIS 385

ALA 397 0.08 GLY 275 -0.05 HIS 385

ALA 397 0.07 SER 276 -0.05 GLU 389

ALA 397 0.07 SER 277 -0.07 GLU 389

ALA 397 0.07 THR 278 -0.04 HIS 385

ALA 397 0.07 MET 279 -0.04 GLY 272

ALA 397 0.07 PRO 280 -0.03 GLY 272

ALA 397 0.07 HIS 281 -0.02 GLU 369

ALA 397 0.08 LYS 282 -0.04 HIS 385

ALA 397 0.07 ARG 283 -0.03 HIS 385

ALA 397 0.08 ASN 284 -0.03 HIS 385

ALA 397 0.08 PRO 285 -0.03 ILE 344

GLN 393 0.08 VAL 286 -0.02 ASP 382

GLN 393 0.08 GLY 287 -0.02 GLN 340

GLN 393 0.08 ALA 288 -0.02 GLU 60

GLN 393 0.08 ALA 289 -0.02 GLY 75

GLN 393 0.08 VAL 290 -0.03 GLY 75

GLN 393 0.08 LEU 291 -0.02 ASN 3

GLN 393 0.08 ILE 292 -0.02 ASN 3

GLN 393 0.08 GLY 293 -0.04 GLY 318

GLN 393 0.09 ALA 294 -0.02 ASN 3

GLN 393 0.08 ALA 295 -0.02 ASN 3

ALA 397 0.08 THR 296 -0.03 GLU 389

ALA 397 0.09 ARG 297 -0.02 GLU 389

GLN 393 0.09 VAL 298 -0.02 GLU 389

GLN 393 0.08 PRO 299 -0.04 SER 303

ALA 397 0.09 GLY 300 -0.03 GLU 389

GLN 393 0.09 LEU 301 -0.03 GLU 389

GLN 393 0.08 LEU 302 -0.03 GLU 389

GLN 393 0.08 SER 303 -0.03 HIS 386

GLN 393 0.09 THR 304 -0.03 HIS 386

GLN 393 0.09 LEU 305 -0.03 HIS 386

GLN 393 0.08 PHE 306 -0.03 HIS 386

ALA 397 0.08 ALA 307 -0.04 HIS 386

GLN 393 0.09 ALA 308 -0.03 HIS 386

GLN 393 0.08 MET 309 -0.03 HIS 386

GLN 393 0.08 PRO 310 -0.04 HIS 386

GLN 393 0.09 GLN 311 -0.03 HIS 386

VAL 396 0.09 GLU 312 -0.03 HIS 386

VAL 396 0.08 HIS 313 -0.03 HIS 386

GLN 393 0.08 GLU 314 -0.03 HIS 386

GLN 393 0.11 ARG 315 -0.03 HIS 386

GLN 393 0.11 SER 316 -0.03 HIS 386

GLN 393 0.14 LEU 317 -0.03 HIS 386

ALA 397 0.13 GLY 318 -0.03 HIS 386

GLN 393 0.11 LEU 319 -0.03 HIS 386

GLN 393 0.12 TRP 320 -0.03 HIS 386

GLN 393 0.13 HIS 321 -0.02 HIS 386

GLN 393 0.12 ALA 322 -0.03 HIS 386

GLN 393 0.11 GLU 323 -0.02 HIS 386

GLN 393 0.12 TRP 324 -0.02 HIS 386

GLN 393 0.12 GLU 325 -0.02 SER 20

GLN 393 0.11 THR 326 -0.02 HIS 386

GLN 393 0.10 LEU 327 -0.02 GLY 65

GLN 393 0.11 PRO 328 -0.03 GLY 65

GLN 393 0.11 ASP 329 -0.02 GLY 65

GLN 393 0.09 ILE 330 -0.02 GLY 65

GLN 393 0.09 CYS 331 -0.03 GLY 65

GLN 393 0.10 CYS 332 -0.04 THR 11

GLN 393 0.09 LEU 333 -0.03 PHE 10

GLN 393 0.09 VAL 334 -0.03 THR 11

GLN 393 0.09 SER 335 -0.04 THR 11

GLN 393 0.09 GLY 336 -0.03 ALA 72

GLN 393 0.08 ALA 337 -0.02 LEU 180

GLN 393 0.08 LEU 338 -0.03 LEU 180

ALA 12 0.09 ARG 339 -0.03 ASP 382

GLN 393 0.08 GLN 340 -0.03 ASP 382

GLN 393 0.08 ALA 341 -0.03 ASP 382

GLN 393 0.08 GLN 342 -0.03 HIS 386

GLN 393 0.08 VAL 343 -0.04 ASP 382

GLN 393 0.07 ILE 344 -0.03 HIS 386

GLN 393 0.07 ALA 345 -0.03 HIS 386

GLN 393 0.07 GLU 346 -0.04 HIS 386

GLN 393 0.08 GLY 347 -0.05 PRO 268

GLN 393 0.07 MET 348 -0.04 GLN 393

GLN 393 0.07 GLU 349 -0.05 GLN 393

ASP 422 0.07 VAL 350 -0.04 ALA 397

ASP 422 0.07 ASP 351 -0.04 ALA 397

ASP 422 0.09 ALA 352 -0.04 GLU 60

ASP 422 0.09 ALA 353 -0.04 GLU 60

GLN 393 0.06 ARG 354 -0.04 GLU 60

GLU 264 0.06 MET 355 -0.04 GLU 60

ARG 403 0.07 ARG 356 -0.04 GLU 60

HIS 401 0.07 ARG 357 -0.04 GLU 60

GLN 393 0.06 ASN 358 -0.04 GLU 60

GLN 393 0.05 LEU 359 -0.05 GLU 60

GLY 364 0.08 ASP 360 -0.05 GLU 60

GLN 363 0.05 LEU 361 -0.05 GLU 60

GLN 393 0.05 THR 362 -0.05 GLU 60

ASP 360 0.08 GLN 363 -0.06 GLU 60

ASP 360 0.08 GLY 364 -0.06 GLU 60

GLN 393 0.04 LEU 365 -0.10 PRO 280

ARG 98 0.04 VAL 366 -0.06 GLU 60

GLN 393 0.04 LEU 367 -0.07 GLU 60

ASP 145 0.03 ALA 368 -0.09 MET 279

ASP 145 0.04 GLU 369 -0.08 GLU 60

ASP 145 0.05 ALA 370 -0.08 GLU 60

SER 372 0.05 VAL 371 -0.08 GLU 60

VAL 371 0.05 SER 372 -0.10 ILE 79

ASP 145 0.05 ILE 373 -0.10 LEU 102

ASP 145 0.06 VAL 374 -0.09 GLU 60

ASP 145 0.05 LEU 375 -0.10 GLU 60

ASP 145 0.05 ALA 376 -0.11 ARG 98

ASP 145 0.05 GLN 377 -0.12 ARG 98

ASP 145 0.05 ARG 378 -0.10 ARG 98

ASP 145 0.05 LEU 379 -0.11 ARG 98

ASP 145 0.04 GLY 380 -0.14 ARG 98

ASP 145 0.04 ARG 381 -0.13 ARG 98

ASP 145 0.03 ASP 382 -0.15 LYS 83

ASP 145 0.04 ARG 383 -0.13 LYS 83

ASP 145 0.04 ALA 384 -0.11 LYS 83

ASP 145 0.03 HIS 385 -0.13 LYS 83

ALA 353 0.03 HIS 386 -0.14 LYS 83

ASP 145 0.04 LEU 387 -0.12 PRO 271

ASP 145 0.04 LEU 388 -0.11 PRO 271

GLN 390 0.07 GLU 389 -0.14 PRO 271

GLU 389 0.07 GLN 390 -0.14 PRO 271

ALA 353 0.05 CYS 391 -0.11 PRO 271

ASP 360 0.04 CYS 392 -0.14 MET 279

GLU 389 0.04 GLN 393 -0.14 PRO 271

ALA 353 0.04 ARG 394 -0.12 PRO 271

ASP 360 0.06 ALA 395 -0.09 SER 269

ASP 360 0.04 VAL 396 -0.11 SER 269

ALA 353 0.03 ALA 397 -0.12 SER 269

ALA 353 0.05 GLU 398 -0.10 SER 269

ALA 353 0.04 GLN 399 -0.09 SER 269

ALA 353 0.06 ARG 400 -0.07 SER 269

ARG 357 0.07 HIS 401 -0.07 MET 279

ASP 360 0.06 LEU 402 -0.09 MET 279

ALA 353 0.08 ARG 403 -0.07 MET 279

ALA 353 0.08 ALA 404 -0.07 GLU 60

ALA 353 0.06 VAL 405 -0.09 PRO 271

ALA 353 0.06 LEU 406 -0.09 GLU 60

ALA 353 0.07 GLY 407 -0.08 GLU 60

ALA 353 0.06 ASP 408 -0.09 PRO 271

ALA 353 0.06 GLU 409 -0.10 PRO 271

ALA 353 0.05 PRO 410 -0.10 GLU 60

ALA 353 0.05 GLN 411 -0.10 GLU 60

ALA 353 0.05 VAL 412 -0.09 GLU 60

ALA 353 0.06 SER 413 -0.09 GLU 60

ALA 353 0.05 ALA 414 -0.09 GLU 60

ASP 145 0.06 GLU 415 -0.09 GLU 60

ASP 145 0.06 LEU 416 -0.08 GLU 60

ALA 353 0.07 SER 417 -0.08 GLU 60

ALA 353 0.08 GLY 418 -0.07 GLU 60

ALA 353 0.08 GLU 419 -0.07 GLU 60

ASP 145 0.07 GLU 420 -0.07 GLU 60

ALA 353 0.07 LEU 421 -0.07 GLU 60

ALA 353 0.09 ASP 422 -0.06 GLU 60

ASP 145 0.09 ARG 423 -0.06 GLU 60

ASP 145 0.07 LEU 424 -0.07 GLU 60

ASP 426 0.08 LEU 425 -0.06 GLU 60

LEU 425 0.08 ASP 426 -0.05 GLU 60

THR 146 0.07 PRO 427 -0.05 GLU 60

ASP 145 0.11 ALA 428 -0.05 GLU 60

ASP 145 0.08 HIS 429 -0.05 GLU 60

ASP 145 0.06 TYR 430 -0.06 GLU 60

ASP 145 0.06 LEU 431 -0.05 GLU 60

GLN 393 0.05 GLY 432 -0.05 GLU 60

GLN 393 0.05 GLN 433 -0.05 GLU 60

GLN 393 0.05 ALA 434 -0.04 GLU 60

GLN 393 0.05 ARG 435 -0.04 GLU 60

GLN 393 0.05 VAL 436 -0.04 GLU 60

GLN 393 0.05 TRP 437 -0.04 GLY 65

GLN 393 0.06 VAL 438 -0.04 GLU 60

GLN 393 0.05 ALA 439 -0.04 GLY 65

GLN 393 0.05 ARG 440 -0.04 GLY 65

GLN 393 0.06 ALA 441 -0.04 GLY 65

GLN 393 0.06 VAL 442 -0.03 GLY 65

ALA 55 0.06 SER 443 -0.03 GLY 65

ALA 55 0.05 GLU 444 -0.03 GLY 65

GLN 393 0.06 HIS 445 -0.03 ALA 397

ALA 55 0.06 GLN 446 -0.03 ALA 397

ALA 55 0.06 ARG 447 -0.04 ALA 450

LYS 218 0.06 PHE 448 -0.03 ALA 450

ALA 55 0.07 THR 449 -0.03 ALA 450

LYS 218 0.08 ALA 450 -0.04 ALA 450

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** 1RE5 ***

CA distance fluctuations for 23010418392238138

--- normal mode 8 ---

Should you encounter any unexpected behaviour,
please let us know.

* 1RE5 *