Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *

CA strain for 22101813491974862

--- normal mode 9 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
ASN 989 LYS 990 0.0022

LYS 990 ALA 991 0.0009

ALA 991 HIS 992 0.0018

HIS 992 ARG 993 0.0011

ARG 993 GLN 994 0.0011

GLN 994 ARG 995 0.0016

ARG 995 VAL 996 0.0018

VAL 996 HIS 997 0.0019

HIS 997 PRO 998 0.0019

PRO 998 PRO 999 0.0018

PRO 999 HIS 1000 0.0009

HIS 1000 ASP 1001 0.0021

ASP 1001 LEU 1002 0.0003

LEU 1002 LEU 1003 0.0022

LEU 1003 GLY 1004 0.0004

GLY 1004 SER 1005 -0.0190

SER 1005 LEU 1006 0.0018

LEU 1006 ILE 1007 0.0021

ILE 1007 VAL 1008 0.0015

VAL 1008 GLY 1009 0.0019

GLY 1009 ARG 1010 -0.0001

ARG 1010 ASP 1011 0.0014

ASP 1011 LEU 1012 0.0023

LEU 1012 ARG 1013 0.0001

ARG 1013 GLU 1014 0.0022

GLU 1014 PRO 1015 0.0010

PRO 1015 THR 1016 0.0021

THR 1016 TRP 1017 0.0016

TRP 1017 ARG 1018 0.0017

ARG 1018 HIS 1019 0.0023

HIS 1019 PHE 1020 0.0016

PHE 1020 ILE 1021 -0.0514

ILE 1021 ARG 1022 0.0015

ARG 1022 VAL 1023 0.0024

VAL 1023 GLN 1024 0.0007

GLN 1024 ASP 1025 0.0027

ASP 1025 ILE 1026 0.0001

ILE 1026 PRO 1027 0.0028

PRO 1027 TRP 1028 0.0004

TRP 1028 ILE 1029 0.0023

ILE 1029 ARG 1030 0.0025

ARG 1030 ASP 1031 0.0011

ASP 1031 HIS 1032 0.0015

HIS 1032 VAL 1033 0.0025

VAL 1033 VAL 1034 0.0010

VAL 1034 GLN 1035 0.0026

GLN 1035 SER 1036 0.0002

SER 1036 ALA 1037 -0.0166

ALA 1037 LEU 1038 0.0017

LEU 1038 VAL 1039 0.0013

VAL 1039 TYR 1040 0.0023

TYR 1040 PRO 1041 0.0014

PRO 1041 GLY 1042 0.0010

GLY 1042 ALA 1043 0.0024

ALA 1043 GLY 1044 0.0003

GLY 1044 PHE 1045 0.0020

PHE 1045 ILE 1046 0.0018

ILE 1046 CYS 1047 0.0007

CYS 1047 MET 1048 0.0019

MET 1048 ALA 1049 0.0013

ALA 1049 MET 1050 0.0024

MET 1050 GLU 1051 -0.0001

GLU 1051 ALA 1052 0.0023

ALA 1052 MET 1053 -0.0013

MET 1053 VAL 1054 0.0013

VAL 1054 GLN 1055 0.0008

GLN 1055 LEU 1056 0.0015

LEU 1056 HIS 1057 0.0019

HIS 1057 GLU 1058 0.0003

GLU 1058 LEU 1059 0.0017

LEU 1059 ARG 1060 0.0012

ARG 1060 ASP 1061 0.0019

ASP 1061 SER 1062 0.0010

SER 1062 GLN 1063 0.0008

GLN 1063 SER 1064 0.0017

SER 1064 ARG 1065 -0.0001

ARG 1065 LYS 1066 0.0020

LYS 1066 VAL 1067 0.0014

VAL 1067 ALA 1068 0.0004

ALA 1068 GLY 1069 0.0053

GLY 1069 TYR 1070 0.0021

TYR 1070 ARG 1071 0.0004

ARG 1071 LEU 1072 0.0018

LEU 1072 ALA 1073 0.0008

ALA 1073 GLU 1074 0.0017

GLU 1074 VAL 1075 0.0009

VAL 1075 ASP 1076 0.0019

ASP 1076 ILE 1077 0.0016

ILE 1077 LEU 1078 0.0020

LEU 1078 ARG 1079 0.0012

ARG 1079 ALA 1080 0.0014

ALA 1080 MET 1081 -0.0000

MET 1081 LEU 1082 0.0017

LEU 1082 ILE 1083 0.0000

ILE 1083 PRO 1084 0.0012

PRO 1084 ASP 1085 0.0148

ASP 1085 THR 1086 0.0010

THR 1086 SER 1087 0.0009

SER 1087 GLU 1088 0.0018

GLU 1088 GLY 1089 0.0005

GLY 1089 LEU 1090 0.0008

LEU 1090 GLU 1091 0.0023

GLU 1091 ALA 1092 0.0010

ALA 1092 HIS 1093 0.0020

HIS 1093 ILE 1094 0.0014

ILE 1094 SER 1095 0.0021

SER 1095 LEU 1096 0.0017

LEU 1096 ARG 1097 0.0017

ARG 1097 PRO 1098 0.0017

PRO 1098 CYS 1099 0.0002

CYS 1099 SER 1100 0.0020

SER 1100 THR 1101 -0.0018

THR 1101 LYS 1102 0.0009

LYS 1102 LEU 1103 0.0020

LEU 1103 LEU 1104 0.0010

LEU 1104 LEU 1105 0.0012

LEU 1105 THR 1106 0.0016

THR 1106 ASN 1107 0.0004

ASN 1107 GLU 1108 0.0004

GLU 1108 TRP 1109 0.0018

TRP 1109 TYR 1110 0.0009

TYR 1110 ASP 1111 0.0020

ASP 1111 PHE 1112 0.0010

PHE 1112 CYS 1113 0.0016

CYS 1113 VAL 1114 0.0011

VAL 1114 SER 1115 0.0016

SER 1115 SER 1116 0.0006

SER 1116 VAL 1117 0.0060

VAL 1117 GLY 1118 0.0019

GLY 1118 ASP 1119 0.0008

ASP 1119 ASP 1120 0.0015

ASP 1120 ASP 1121 0.0019

ASP 1121 LYS 1122 0.0001

LYS 1122 PHE 1123 0.0013

PHE 1123 VAL 1124 0.0012

VAL 1124 ASP 1125 0.0012

ASP 1125 HIS 1126 0.0019

HIS 1126 CYS 1127 0.0015

CYS 1127 ARG 1128 0.0013

ARG 1128 GLY 1129 0.0012

GLY 1129 ARG 1130 0.0020

ARG 1130 ILE 1131 0.0014

ILE 1131 THR 1132 0.0018

THR 1132 ILE 1133 0.0065

ILE 1133 GLU 1134 0.0011

GLU 1134 PHE 1135 0.0012

PHE 1135 ASP 1136 0.0018

ASP 1136 THR 1137 0.0010

THR 1137 SER 1138 0.0015

SER 1138 GLY 1139 -0.0001

GLY 1139 SER 1140 0.0011

SER 1140 ALA 1141 0.0016

ALA 1141 ASP 1142 0.0016

ASP 1142 THR 1143 0.0007

THR 1143 PRO 1144 0.0018

PRO 1144 ARG 1145 0.0016

ARG 1145 THR 1146 0.0008

THR 1146 SER 1147 0.0013

SER 1147 LEU 1148 0.0018

LEU 1148 ARG 1149 -0.0116

ARG 1149 GLU 1150 0.0006

GLU 1150 ARG 1151 0.0027

ARG 1151 SER 1152 0.0027

SER 1152 ARG 1153 0.0008

ARG 1153 SER 1154 0.0021

SER 1154 THR 1155 0.0025

THR 1155 GLY 1156 0.0024

GLY 1156 LEU 1157 0.0017

LEU 1157 MET 1158 0.0006

MET 1158 ARG 1159 0.0023

ARG 1159 SER 1160 0.0001

SER 1160 VAL 1161 0.0025

VAL 1161 ASP 1162 0.0004

ASP 1162 PRO 1163 0.0022

PRO 1163 SER 1164 0.0024

SER 1164 ASN 1165 0.0485

ASN 1165 LEU 1166 0.0017

LEU 1166 TYR 1167 0.0003

TYR 1167 SER 1168 0.0018

SER 1168 PHE 1169 0.0007

PHE 1169 LEU 1170 0.0016

LEU 1170 ARG 1171 0.0007

ARG 1171 ALA 1172 0.0011

ALA 1172 GLN 1173 0.0016

GLN 1173 GLY 1174 0.0003

GLY 1174 ILE 1175 0.0016

ILE 1175 TYR 1176 0.0005

TYR 1176 HIS 1177 0.0017

HIS 1177 GLY 1178 0.0005

GLY 1178 PRO 1179 0.0017

PRO 1179 ILE 1180 0.0016

ILE 1180 PHE 1181 -0.0034

PHE 1181 GLN 1182 0.0018

GLN 1182 ASN 1183 0.0023

ASN 1183 LEU 1184 0.0002

LEU 1184 LYS 1185 0.0024

LYS 1185 THR 1186 0.0002

THR 1186 ILE 1187 0.0007

ILE 1187 SER 1188 0.0006

SER 1188 SER 1189 0.0011

SER 1189 ARG 1190 -0.0001

ARG 1190 LYS 1191 0.0017

LYS 1191 ASP 1192 0.0021

ASP 1192 HIS 1193 0.0008

HIS 1193 SER 1194 0.0005

SER 1194 GLU 1195 0.0010

GLU 1195 SER 1196 0.0004

SER 1196 SER 1197 -0.0068

SER 1197 PHE 1198 0.0004

PHE 1198 VAL 1199 0.0004

VAL 1199 VAL 1200 0.0013

VAL 1200 ALA 1201 0.0011

ALA 1201 ASN 1202 0.0003

ASN 1202 THR 1203 0.0021

THR 1203 ALA 1204 0.0001

ALA 1204 SER 1205 0.0023

SER 1205 VAL 1206 0.0022

VAL 1206 MET 1207 0.0016

MET 1207 PRO 1208 0.0002

PRO 1208 ASN 1209 0.0018

ASN 1209 GLY 1210 0.0006

GLY 1210 PHE 1211 0.0023

PHE 1211 GLN 1212 0.0005

GLN 1212 SER 1213 0.0080

SER 1213 PRO 1214 0.0018

PRO 1214 HIS 1215 0.0002

HIS 1215 VAL 1216 0.0006

VAL 1216 ILE 1217 0.0022

ILE 1217 HIS 1218 0.0023

HIS 1218 PRO 1219 0.0019

PRO 1219 THR 1220 0.0025

THR 1220 THR 1221 0.0021

THR 1221 LEU 1222 0.0015

LEU 1222 ASP 1223 0.0025

ASP 1223 SER 1224 0.0025

SER 1224 ILE 1225 0.0011

ILE 1225 PHE 1226 0.0022

PHE 1226 GLN 1227 0.0025

GLN 1227 GLY 1228 0.0016

GLY 1228 ALA 1229 -0.0012

ALA 1229 TYR 1230 0.0018

TYR 1230 THR 1231 0.0022

THR 1231 ALA 1232 0.0011

ALA 1232 LEU 1233 0.0017

LEU 1233 PRO 1234 0.0011

PRO 1234 GLY 1235 0.0020

GLY 1235 ALA 1236 0.0006

ALA 1236 GLY 1237 0.0023

GLY 1237 LEU 1238 0.0023

LEU 1238 ASP 1239 0.0005

ASP 1239 GLN 1240 0.0019

GLN 1240 ASN 1241 0.0022

ASN 1241 THR 1242 0.0009

THR 1242 ALA 1243 0.0003

ALA 1243 MET 1244 0.0024

MET 1244 ILE 1245 0.0135

ILE 1245 PRO 1246 0.0023

PRO 1246 ARG 1247 0.0019

ARG 1247 SER 1248 0.0020

SER 1248 ILE 1249 0.0023

ILE 1249 GLN 1250 0.0015

GLN 1250 GLU 1251 0.0014

GLU 1251 LEU 1252 0.0008

LEU 1252 TYR 1253 0.0019

TYR 1253 LEU 1254 0.0006

LEU 1254 SER 1255 0.0019

SER 1255 SER 1256 0.0002

SER 1256 ALA 1257 0.0021

ALA 1257 LEU 1258 0.0021

LEU 1258 THR 1259 0.0007

THR 1259 SER 1260 0.0017

SER 1260 ASP 1261 0.0024

ASP 1261 VAL 1262 0.0020

VAL 1262 GLY 1263 0.0010

GLY 1263 GLN 1264 0.0013

GLN 1264 CYS 1265 0.0003

CYS 1265 LEU 1266 0.0011

LEU 1266 VAL 1267 0.0000

VAL 1267 SER 1268 0.0013

SER 1268 ASP 1269 0.0000

ASP 1269 THR 1270 0.0016

THR 1270 SER 1271 0.0004

SER 1271 LEU 1272 0.0016

LEU 1272 ILE 1273 0.0013

ILE 1273 ARG 1274 0.0018

ARG 1274 TYR 1275 0.0021

TYR 1275 ASP 1276 0.0015

ASP 1276 GLY 1277 -0.0112

GLY 1277 GLN 1278 0.0010

GLN 1278 SER 1279 0.0018

SER 1279 PHE 1280 0.0020

PHE 1280 THR 1281 0.0020

THR 1281 VAL 1282 0.0018

VAL 1282 ASN 1283 0.0017

ASN 1283 VAL 1284 0.0011

VAL 1284 ASP 1285 0.0018

ASP 1285 VAL 1286 0.0007

VAL 1286 SER 1287 0.0017

SER 1287 SER 1288 0.0010

SER 1288 LYS 1289 0.0018

LYS 1289 ALA 1290 0.0015

ALA 1290 ASP 1291 0.0015

ASP 1291 SER 1292 0.0009

SER 1292 GLU 1293 0.0018

GLU 1293 HIS 1294 0.0022

HIS 1294 THR 1295 0.0020

THR 1295 PRO 1296 0.0020

PRO 1296 VAL 1297 0.0004

VAL 1297 LEU 1298 0.0020

LEU 1298 GLU 1299 0.0004

GLU 1299 ILE 1300 0.0021

ILE 1300 LYS 1301 0.0006

LYS 1301 GLY 1302 0.0017

GLY 1302 LEU 1303 0.0009

LEU 1303 ARG 1304 0.0018

ARG 1304 ASN 1305 0.0018

ASN 1305 GLN 1306 0.0021

GLN 1306 SER 1307 0.0021

SER 1307 VAL 1308 0.0007

VAL 1308 GLY 1309 0.1108

GLY 1309 GLN 1310 0.0094

GLN 1310 MET 1311 0.0157

MET 1311 ALA 1312 0.0024

ALA 1312 PRO 1313 0.0149

PRO 1313 GLN 1314 0.0154

GLN 1314 PRO 1315 0.0034

PRO 1315 GLY 1316 0.0156

GLY 1316 ASP 1317 0.0113

ASP 1317 SER 1318 0.0066

SER 1318 SER 1319 0.0155

SER 1319 ASN 1320 0.0083

ASN 1320 ASN 1321 0.0088

ASN 1321 ASP 1322 0.0104

ASP 1322 LEU 1323 0.0126

LEU 1323 CYS 1324 0.0039

CYS 1324 PHE 1325 0.0913

PHE 1325 LYS 1326 0.0502

LYS 1326 LEU 1327 0.0387

LEU 1327 ASP 1328 0.0218

ASP 1328 TRP 1329 0.0398

TRP 1329 ALA 1330 0.0077

ALA 1330 PRO 1331 0.0232

PRO 1331 ASP 1332 0.0373

ASP 1332 ILE 1333 0.0146

ILE 1333 SER 1334 0.0427

SER 1334 SER 1335 0.0505

SER 1335 VAL 1336 0.0552

VAL 1336 LYS 1337 0.0396

LYS 1337 GLN 1338 0.0342

GLN 1338 GLU 1339 0.0507

GLU 1339 ARG 1340 0.0084

ARG 1340 LEU 1341 -0.0092

LEU 1341 LYS 1342 0.0521

LYS 1342 GLU 1343 0.0255

GLU 1343 LYS 1344 0.0457

LYS 1344 PHE 1345 0.0440

PHE 1345 GLY 1346 0.0400

GLY 1346 PHE 1347 0.0695

PHE 1347 PRO 1348 0.0682

PRO 1348 LEU 1349 0.0396

LEU 1349 ASP 1350 0.0582

ASP 1350 PRO 1351 0.0593

PRO 1351 THR 1352 0.0689

THR 1352 GLU 1353 0.0503

GLU 1353 ALA 1354 0.0359

ALA 1354 ASP 1355 0.0688

ASP 1355 ILE 1356 0.0694

ILE 1356 ILE 1357 0.0536

ILE 1357 MET 1358 0.0541

MET 1358 GLY 1359 0.0708

GLY 1359 LEU 1360 0.0638

LEU 1360 ARG 1361 0.0284

ARG 1361 GLN 1362 0.0685

GLN 1362 ALA 1363 0.0705

ALA 1363 CYS 1364 0.0456

CYS 1364 ILE 1365 0.0378

ILE 1365 HIS 1366 0.0709

HIS 1366 PHE 1367 0.0700

PHE 1367 ILE 1368 0.0333

ILE 1368 HIS 1369 0.0569

HIS 1369 ARG 1370 0.0709

ARG 1370 SER 1371 0.0640

SER 1371 LEU 1372 0.0301

LEU 1372 GLN 1373 0.0681

GLN 1373 SER 1374 0.0712

SER 1374 LEU 1375 0.0558

LEU 1375 THR 1376 0.0091

THR 1376 ALA 1377 0.0309

ALA 1377 PRO 1378 0.0712

PRO 1378 ASP 1379 0.0021

ASP 1379 ARG 1380 0.0693

ARG 1380 ASP 1381 0.0375

ASP 1381 GLN 1382 0.0435

GLN 1382 LEU 1383 0.0350

LEU 1383 ASP 1384 0.0659

ASP 1384 TRP 1385 0.0703

TRP 1385 HIS 1386 0.0068

HIS 1386 GLN 1387 0.0711

GLN 1387 LYS 1388 0.0276

LYS 1388 ARG 1389 0.0463

ARG 1389 PHE 1390 0.0371

PHE 1390 TYR 1391 0.0373

TYR 1391 ASP 1392 0.0661

ASP 1392 TRP 1393 0.0062

TRP 1393 MET 1394 0.0707

MET 1394 VAL 1395 0.0271

VAL 1395 LEU 1396 0.0629

LEU 1396 GLN 1397 0.0168

GLN 1397 ILE 1398 0.0583

ILE 1398 GLN 1399 0.0540

GLN 1399 LEU 1400 0.0211

LEU 1400 ALA 1401 0.0594

ALA 1401 GLU 1402 0.0317

GLU 1402 GLU 1403 0.0714

GLU 1403 ASP 1404 0.0040

ASP 1404 ARG 1405 0.0699

ARG 1405 LEU 1406 0.0456

LEU 1406 ALA 1407 0.0431

ALA 1407 PRO 1408 0.0713

PRO 1408 ASN 1409 0.0562

ASN 1409 SER 1410 0.0683

SER 1410 SER 1411 0.0192

SER 1411 ALA 1412 0.0509

ALA 1412 TRP 1413 0.0651

TRP 1413 LEU 1414 0.0122

LEU 1414 GLN 1415 0.0710

GLN 1415 CYS 1416 0.0208

CYS 1416 SER 1417 0.0705

SER 1417 SER 1418 0.0701

SER 1418 SER 1419 0.0118

SER 1419 ASP 1420 0.0674

ASP 1420 GLU 1421 0.0660

GLU 1421 GLN 1422 0.0499

GLN 1422 LYS 1423 0.0236

LYS 1423 LEU 1424 0.0679

LEU 1424 LEU 1425 0.0700

LEU 1425 GLU 1426 0.0201

GLU 1426 ASN 1427 0.0546

ASN 1427 VAL 1428 0.0585

VAL 1428 ARG 1429 0.0689

ARG 1429 ALA 1430 0.0062

ALA 1430 SER 1431 0.0704

SER 1431 SER 1432 0.0693

SER 1432 VAL 1433 0.0656

VAL 1433 ASN 1434 0.0251

ASN 1434 GLY 1435 0.0690

GLY 1435 GLN 1436 0.0696

GLN 1436 MET 1437 0.0387

MET 1437 VAL 1438 0.0405

VAL 1438 VAL 1439 0.0703

VAL 1439 HIS 1440 0.0705

HIS 1440 VAL 1441 0.0281

VAL 1441 GLY 1442 0.0574

GLY 1442 LYS 1443 0.0706

LYS 1443 SER 1444 0.0568

SER 1444 MET 1445 0.0478

MET 1445 LEU 1446 0.0216

LEU 1446 ALA 1447 0.0677

ALA 1447 ILE 1448 0.0688

ILE 1448 LEU 1449 0.0184

LEU 1449 ARG 1450 0.0579

ARG 1450 HIS 1451 0.0581

HIS 1451 GLU 1452 0.0527

GLU 1452 ILE 1453 0.0303

ILE 1453 ALA 1454 0.0662

ALA 1454 PRO 1455 0.0551

PRO 1455 LEU 1456 0.0424

LEU 1456 GLU 1457 0.0645

GLU 1457 LEU 1458 0.0689

LEU 1458 MET 1459 0.0486

MET 1459 LEU 1460 0.0511

LEU 1460 GLN 1461 0.0668

GLN 1461 ASP 1462 0.0042

ASP 1462 LYS 1463 0.0697

LYS 1463 LEU 1464 0.0624

LEU 1464 LEU 1465 0.0593

LEU 1465 TYR 1466 0.0177

TYR 1466 ARG 1467 0.0566

ARG 1467 TYR 1468 0.0355

TYR 1468 TYR 1469 0.0789

TYR 1469 THR 1470 0.0033

THR 1470 ASP 1471 0.0671

ASP 1471 ALA 1472 0.0235

ALA 1472 ILE 1473 0.0673

ILE 1473 LYS 1474 0.0677

LYS 1474 TRP 1475 0.0656

TRP 1475 ASP 1476 0.0004

ASP 1476 ARG 1477 0.0676

ARG 1477 SER 1478 0.0435

SER 1478 TYR 1479 0.0468

TYR 1479 GLN 1480 0.0231

GLN 1480 GLN 1481 0.0536

GLN 1481 ILE 1482 0.0650

ILE 1482 ASP 1483 0.0083

ASP 1483 GLN 1484 0.0608

GLN 1484 LEU 1485 0.0336

LEU 1485 VAL 1486 0.0598

VAL 1486 LYS 1487 0.0025

LYS 1487 LEU 1488 0.0609

LEU 1488 HIS 1489 0.0405

HIS 1489 ALA 1490 0.0377

ALA 1490 HIS 1491 0.0273

HIS 1491 LYS 1492 0.0455

LYS 1492 CYS 1493 0.0533

CYS 1493 PRO 1494 0.0416

PRO 1494 THR 1495 0.0479

THR 1495 ALA 1496 0.0120

ALA 1496 LYS 1497 0.0312

LYS 1497 ILE 1498 0.0520

ILE 1498 ILE 1499 0.0173

ILE 1499 GLU 1500 0.0571

GLU 1500 ILE 1501 0.0029

ILE 1501 GLY 1502 0.0635

GLY 1502 ALA 1503 0.0083

ALA 1503 GLY 1504 0.0594

GLY 1504 THR 1505 0.0345

THR 1505 GLY 1506 0.0371

GLY 1506 GLY 1507 0.0666

GLY 1507 CYS 1508 0.0667

CYS 1508 THR 1509 0.0544

THR 1509 ARG 1510 0.0243

ARG 1510 ALA 1511 0.0658

ALA 1511 VAL 1512 0.0652

VAL 1512 LEU 1513 0.0422

LEU 1513 ASP 1514 0.0357

ASP 1514 ALA 1515 0.0661

ALA 1515 LEU 1516 0.0671

LEU 1516 SER 1517 0.0366

SER 1517 ASN 1518 0.0137

ASN 1518 GLN 1519 0.0381

GLN 1519 GLY 1520 0.0481

GLY 1520 ILE 1521 0.0584

ILE 1521 ALA 1522 0.0050

ALA 1522 ARG 1523 0.0584

ARG 1523 CYS 1524 0.0199

CYS 1524 ALA 1525 0.0588

ALA 1525 GLN 1526 0.0301

GLN 1526 TYR 1527 0.0477

TYR 1527 ASP 1528 0.0112

ASP 1528 PHE 1529 0.0584

PHE 1529 THR 1530 0.0008

THR 1530 ASP 1531 0.0306

ASP 1531 VAL 1532 0.0063

VAL 1532 SER 1533 0.0569

SER 1533 SER 1534 0.0260

SER 1534 GLY 1535 0.0665

GLY 1535 PHE 1536 0.0274

PHE 1536 PHE 1537 0.0484

PHE 1537 GLU 1538 0.0509

GLU 1538 ALA 1539 0.0620

ALA 1539 ALA 1540 0.0633

ALA 1540 GLN 1541 0.0485

GLN 1541 GLN 1542 0.0490

GLN 1542 LYS 1543 0.0661

LYS 1543 PHE 1544 0.0611

PHE 1544 ALA 1545 0.0498

ALA 1545 ALA 1546 0.0290

ALA 1546 PHE 1547 0.0480

PHE 1547 ASP 1548 0.0573

ASP 1548 ASP 1549 0.0885

ASP 1549 VAL 1550 0.0464

VAL 1550 ILE 1551 0.0261

ILE 1551 ARG 1552 0.0266

ARG 1552 PHE 1553 0.0310

PHE 1553 GLN 1554 0.0105

GLN 1554 LYS 1555 0.0081

LYS 1555 LEU 1556 0.0531

LEU 1556 ASP 1557 0.0089

ASP 1557 ILE 1558 0.0670

ILE 1558 GLU 1559 0.0003

GLU 1559 LYS 1560 0.0671

LYS 1560 ASP 1561 0.0613

ASP 1561 ILE 1562 0.0003

ILE 1562 GLU 1563 0.0656

GLU 1563 MET 1564 0.0460

MET 1564 GLN 1565 0.0372

GLN 1565 GLY 1566 0.0247

GLY 1566 PHE 1567 0.0570

PHE 1567 GLU 1568 0.0622

GLU 1568 CYS 1569 0.0551

CYS 1569 GLY 1570 0.0420

GLY 1570 SER 1571 0.0248

SER 1571 TYR 1572 0.0620

TYR 1572 ASP 1573 0.0449

ASP 1573 LEU 1574 0.0635

LEU 1574 VAL 1575 0.0241

VAL 1575 ILE 1576 0.0661

ILE 1576 ALA 1577 0.0245

ALA 1577 SER 1578 0.0659

SER 1578 GLN 1579 0.0233

GLN 1579 VAL 1580 0.0484

VAL 1580 LEU 1581 0.0490

LEU 1581 HIS 1582 0.0467

HIS 1582 ALA 1583 0.0598

ALA 1583 THR 1584 0.0520

THR 1584 GLY 1585 0.0049

GLY 1585 LYS 1586 0.0678

LYS 1586 MET 1587 0.0206

MET 1587 GLU 1588 0.0675

GLU 1588 HIS 1589 0.0681

HIS 1589 THR 1590 0.0268

THR 1590 MET 1591 0.0484

MET 1591 ALA 1592 0.0629

ALA 1592 ASN 1593 0.0598

ASN 1593 VAL 1594 0.0207

VAL 1594 ARG 1595 0.0677

ARG 1595 LYS 1596 0.0682

LYS 1596 LEU 1597 0.0139

LEU 1597 LEU 1598 0.0466

LEU 1598 LYS 1599 0.0542

LYS 1599 PRO 1600 0.0654

PRO 1600 GLY 1601 0.0460

GLY 1601 GLY 1602 0.0669

GLY 1602 LYS 1603 0.0673

LYS 1603 LEU 1604 0.0395

LEU 1604 LEU 1605 0.0592

LEU 1605 LEU 1606 0.0341

LEU 1606 VAL 1607 0.0671

VAL 1607 GLU 1608 0.0106

GLU 1608 THR 1609 0.0522

THR 1609 THR 1610 0.0626

THR 1610 ARG 1611 0.0621

ARG 1611 ASP 1612 0.0584

ASP 1612 GLU 1613 0.0602

GLU 1613 MET 1614 0.0487

MET 1614 ASP 1615 0.0463

ASP 1615 LEU 1616 0.0705

LEU 1616 GLN 1617 0.0010

GLN 1617 LEU 1618 0.0688

LEU 1618 VAL 1619 0.0456

VAL 1619 PHE 1620 0.0654

PHE 1620 GLY 1621 0.0082

GLY 1621 LEU 1622 0.0670

LEU 1622 LEU 1623 0.0676

LEU 1623 PRO 1624 0.0386

PRO 1624 GLY 1625 0.0391

GLY 1625 TRP 1626 0.0701

TRP 1626 TRP 1627 0.0070

TRP 1627 LEU 1628 0.0702

LEU 1628 SER 1629 0.0655

SER 1629 SER 1630 0.0170

SER 1630 GLU 1631 0.0641

GLU 1631 GLU 1632 0.0550

GLU 1632 GLU 1633 0.0209

GLU 1633 ARG 1634 0.0580

ARG 1634 GLN 1635 0.0323

GLN 1635 MET 1636 0.0587

MET 1636 SER 1637 0.0083

SER 1637 PRO 1638 0.0569

PRO 1638 SER 1639 0.0400

SER 1639 LEU 1640 0.0694

LEU 1640 SER 1641 0.0602

SER 1641 THR 1642 0.0308

THR 1642 ASN 1643 0.0426

ASN 1643 SER 1644 0.0443

SER 1644 TRP 1645 0.0210

TRP 1645 GLU 1646 0.0634

GLU 1646 LYS 1647 0.0104

LYS 1647 VAL 1648 0.0673

VAL 1648 LEU 1649 0.0133

LEU 1649 LYS 1650 0.0631

LYS 1650 LYS 1651 0.0191

LYS 1651 THR 1652 0.0537

THR 1652 GLY 1653 0.0357

GLY 1653 PHE 1654 0.0326

PHE 1654 ASP 1655 0.0605

ASP 1655 GLY 1656 0.0653

GLY 1656 LEU 1657 0.0425

LEU 1657 ASP 1658 0.0073

ASP 1658 ILE 1659 0.0606

ILE 1659 GLU 1660 0.0563

GLU 1660 LEU 1661 0.0487

LEU 1661 ARG 1662 0.0574

ARG 1662 ASP 1663 0.0620

ASP 1663 CYS 1664 0.0677

CYS 1664 ASP 1665 0.0684

ASP 1665 SER 1666 0.0274

SER 1666 ASP 1667 0.0095

ASP 1667 GLU 1668 0.0619

GLU 1668 PHE 1669 0.0500

PHE 1669 TYR 1670 0.0660

TYR 1670 SER 1671 0.0528

SER 1671 PHE 1672 0.0534

PHE 1672 SER 1673 0.0650

SER 1673 VAL 1674 0.0393

VAL 1674 MET 1675 0.0585

MET 1675 MET 1676 0.0597

MET 1676 ALA 1677 0.0679

ALA 1677 THR 1678 0.0534

THR 1678 ALA 1679 0.0462

ALA 1679 SER 1680 0.0567

SER 1680 SER 1681 0.0391

SER 1681 THR 1682 0.0572

THR 1682 ILE 1683 0.0237

ILE 1683 ALA 1684 0.0585

ALA 1684 SER 1685 0.0579

SER 1685 SER 1686 0.0126

SER 1686 SER 1687 0.0567

SER 1687 MET 1688 0.0059

MET 1688 ALA 1689 0.0405

ALA 1689 PHE 1690 0.0438

PHE 1690 ALA 1691 0.0191

ALA 1691 ILE 1692 0.0497

ILE 1692 VAL 1693 -0.0083

VAL 1693 TYR 1694 0.0355

TYR 1694 GLY 1695 0.0006

GLY 1695 GLU 1696 0.0339

GLU 1696 VAL 1697 0.0385

VAL 1697 PRO 1698 0.0091

PRO 1698 LEU 1699 0.0230

LEU 1699 PRO 1700 0.0401

PRO 1700 ASP 1701 0.0265

ASP 1701 GLN 1702 0.0281

GLN 1702 PHE 1703 0.0501

PHE 1703 LEU 1704 0.0538

LEU 1704 ASP 1705 0.0093

ASP 1705 ASP 1706 0.0472

ASP 1706 MET 1707 0.0441

MET 1707 LYS 1708 0.0459

LYS 1708 THR 1709 0.0142

THR 1709 ALA 1710 0.0543

ALA 1710 ILE 1711 0.0501

ILE 1711 SER 1712 0.0293

SER 1712 SER 1713 0.0287

SER 1713 SER 1714 0.0494

SER 1714 ALA 1715 0.0520

ALA 1715 VAL 1716 0.0453

VAL 1716 SER 1717 0.0238

SER 1717 ASP 1718 0.0433

ASP 1718 PRO 1719 0.0053

PRO 1719 VAL 1720 0.0244

VAL 1720 VAL 1721 0.0310

VAL 1721 GLY 1722 0.0047

GLY 1722 HIS 1723 0.0041

HIS 1723 LEU 1724 0.0439

LEU 1724 ASP 1725 0.0302

ASP 1725 SER 1726 0.0236

SER 1726 ILE 1727 0.0196

ILE 1727 ASP 1728 0.0470

ASP 1728 ALA 1729 0.0511

ALA 1729 THR 1730 0.0499

THR 1730 GLY 1731 0.0160

GLY 1731 LYS 1732 0.0518

LYS 1732 PHE 1733 0.0532

PHE 1733 CYS 1734 0.0278

CYS 1734 ILE 1735 0.0532

ILE 1735 PHE 1736 0.0041

PHE 1736 ILE 1737 0.0526

ILE 1737 GLU 1738 0.0041

GLU 1738 ASP 1739 0.0471

ASP 1739 PRO 1740 0.0497

PRO 1740 GLU 1741 0.0008

GLU 1741 THR 1742 0.0480

THR 1742 ASP 1743 0.0499

ASP 1743 ILE 1744 0.0527

ILE 1744 LEU 1745 0.0489

LEU 1745 SER 1746 0.0248

SER 1746 SER 1747 0.0361

SER 1747 PRO 1748 0.0405

PRO 1748 ASP 1749 0.0460

ASP 1749 GLU 1750 0.0525

GLU 1750 LYS 1751 0.0191

LYS 1751 SER 1752 0.0371

SER 1752 TYR 1753 0.0500

TYR 1753 ALA 1754 0.0485

ALA 1754 SER 1755 0.0153

SER 1755 ILE 1756 0.0506

ILE 1756 GLN 1757 0.0592

GLN 1757 LYS 1758 0.0318

LYS 1758 LEU 1759 0.0274

LEU 1759 VAL 1760 0.0526

VAL 1760 THR 1761 0.0524

THR 1761 ARG 1762 0.0255

ARG 1762 CYS 1763 0.0291

CYS 1763 LYS 1764 0.0209

LYS 1764 GLY 1765 0.0516

GLY 1765 LEU 1766 0.0414

LEU 1766 ILE 1767 0.0515

ILE 1767 TRP 1768 0.0117

TRP 1768 VAL 1769 0.0517

VAL 1769 SER 1770 0.0272

SER 1770 ARG 1771 0.0518

ARG 1771 GLY 1772 0.0424

GLY 1772 GLY 1773 0.0578

GLY 1773 ALA 1774 0.0341

ALA 1774 MET 1775 0.0463

MET 1775 HIS 1776 0.0295

HIS 1776 GLY 1777 0.0274

GLY 1777 THR 1778 0.0495

THR 1778 ARG 1779 0.0436

ARG 1779 PRO 1780 0.0366

PRO 1780 ASN 1781 0.0490

ASN 1781 SER 1782 0.0010

SER 1782 SER 1783 0.0495

SER 1783 LEU 1784 0.0357

LEU 1784 LYS 1785 0.0155

LYS 1785 THR 1786 0.0404

THR 1786 GLY 1787 0.0214

GLY 1787 LEU 1788 0.0495

LEU 1788 LEU 1789 -0.0035

LEU 1789 ARG 1790 0.0514

ARG 1790 THR 1791 0.0351

THR 1791 LEU 1792 0.0354

LEU 1792 ARG 1793 0.0191

ARG 1793 LEU 1794 0.0389

LEU 1794 GLU 1795 0.0463

GLU 1795 TYR 1796 0.0107

TYR 1796 THR 1797 0.0275

THR 1797 GLU 1798 0.0259

GLU 1798 LYS 1799 0.0502

LYS 1799 ARG 1800 0.0466

ARG 1800 PHE 1801 0.0217

PHE 1801 ILE 1802 0.0479

ILE 1802 SER 1803 0.0347

SER 1803 LEU 1804 0.0412

LEU 1804 ASP 1805 0.0494

ASP 1805 LEU 1806 0.0439

LEU 1806 ASP 1807 0.0542

ASP 1807 SER 1808 0.0146

SER 1808 ALA 1809 0.0479

ALA 1809 ARG 1810 0.0262

ARG 1810 PRO 1811 0.0544

PRO 1811 GLN 1812 0.0493

GLN 1812 TRP 1813 0.0221

TRP 1813 ASN 1814 0.0156

ASN 1814 HIS 1815 0.0076

HIS 1815 ASP 1816 0.0538

ASP 1816 SER 1817 0.0252

SER 1817 ILE 1818 0.0351

ILE 1818 THR 1819 0.0293

THR 1819 THR 1820 0.0312

THR 1820 ILE 1821 0.0574

ILE 1821 ASN 1822 0.0068

ASN 1822 GLU 1823 0.0547

GLU 1823 VAL 1824 0.0246

VAL 1824 LEU 1825 0.0532

LEU 1825 CYS 1826 0.0063

CYS 1826 GLY 1827 0.0511

GLY 1827 ALA 1828 0.0396

ALA 1828 LEU 1829 0.0222

LEU 1829 ALA 1830 0.0268

ALA 1830 GLN 1831 0.0497

GLN 1831 ASN 1832 0.0419

ASN 1832 ALA 1833 0.0471

ALA 1833 ASP 1834 0.0571

ASP 1834 SER 1835 0.0426

SER 1835 SER 1836 0.0207

SER 1836 ILE 1837 0.0365

ILE 1837 LYS 1838 0.0539

LYS 1838 ASP 1839 0.0427

ASP 1839 SER 1840 0.0290

SER 1840 GLU 1841 0.0440

GLU 1841 PHE 1842 0.0443

PHE 1842 ALA 1843 0.0501

ALA 1843 GLU 1844 0.0422

GLU 1844 GLN 1845 0.0541

GLN 1845 ASP 1846 0.0402

ASP 1846 GLY 1847 0.0312

GLY 1847 GLN 1848 0.0542

GLN 1848 LEU 1849 0.0514

LEU 1849 PHE 1850 0.0356

PHE 1850 VAL 1851 0.0526

VAL 1851 PRO 1852 0.0204

PRO 1852 ARG 1853 0.1388

ARG 1853 ILE 1854 0.0104

ILE 1854 SER 1855 0.0246

SER 1855 CYS 1856 0.0177

CYS 1856 ASP 1857 0.0200

ASP 1857 ILE 1858 0.0236

ILE 1858 ALA 1859 0.0216

ALA 1859 ARG 1860 0.0046

ARG 1860 ASN 1861 0.0253

ASN 1861 GLU 1862 0.0239

GLU 1862 ASP 1863 0.0101

ASP 1863 LEU 1864 0.0162

LEU 1864 SER 1865 0.0227

SER 1865 SER 1866 0.0255

SER 1866 ASP 1867 0.0051

ASP 1867 SER 1868 0.0204

SER 1868 ASN 1869 -0.1593

ASN 1869 SER 1870 0.0022

SER 1870 PRO 1871 0.0035

PRO 1871 ALA 1872 0.0040

ALA 1872 GLN 1873 0.0029

GLN 1873 MET 1874 0.0045

MET 1874 GLU 1875 0.0011

GLU 1875 PRO 1876 0.0042

PRO 1876 PHE 1877 0.0037

PHE 1877 HIS 1878 0.0012

HIS 1878 GLN 1879 0.0016

GLN 1879 PRO 1880 0.0010

PRO 1880 GLY 1881 0.0042

GLY 1881 LYS 1882 0.0011

LYS 1882 LEU 1883 0.0019

LEU 1883 LEU 1884 0.0007

LEU 1884 GLN 1885 -0.0224

GLN 1885 MET 1886 0.0013

MET 1886 GLY 1887 0.0003

GLY 1887 ILE 1888 0.0011

ILE 1888 LYS 1889 0.0023

LYS 1889 THR 1890 0.0003

THR 1890 PRO 1891 0.0021

PRO 1891 GLY 1892 0.0020

GLY 1892 LEU 1893 0.0015

LEU 1893 ILE 1894 0.0010

ILE 1894 ASP 1895 0.0019

ASP 1895 THR 1896 0.0025

THR 1896 LEU 1897 0.0016

LEU 1897 GLN 1898 0.0009

GLN 1898 PHE 1899 0.0013

PHE 1899 SER 1900 0.0025

SER 1900 LYS 1901 0.0205

LYS 1901 THR 1902 0.0020

THR 1902 ASP 1903 0.0007

ASP 1903 ALA 1904 0.0018

ALA 1904 THR 1905 0.0021

THR 1905 ASP 1906 0.0010

ASP 1906 ASN 1907 0.0022

ASN 1907 LEU 1908 0.0016

LEU 1908 PRO 1909 0.0020

PRO 1909 ASN 1910 0.0018

ASN 1910 ASP 1911 0.0004

ASP 1911 TYR 1912 0.0021

TYR 1912 ILE 1913 0.0022

ILE 1913 GLU 1914 0.0022

GLU 1914 ILE 1915 0.0018

ILE 1915 GLU 1916 0.0021

GLU 1916 PRO 1917 0.0033

PRO 1917 LYS 1918 0.0010

LYS 1918 ALA 1919 0.0000

ALA 1919 PHE 1920 0.0002

PHE 1920 GLY 1921 0.0001

GLY 1921 LEU 1922 0.0007

LEU 1922 ASN 1923 0.0001

ASN 1923 PHE 1924 0.0004

PHE 1924 ARG 1925 0.0010

ARG 1925 ASP 1926 0.0004

ASP 1926 VAL 1927 0.0006

VAL 1927 MET 1928 0.0005

MET 1928 VAL 1929 0.0007

VAL 1929 ALA 1930 0.0010

ALA 1930 MET 1931 0.0001

MET 1931 GLY 1932 0.0008

GLY 1932 GLN 1933 0.0444

GLN 1933 LEU 1934 0.0009

LEU 1934 GLU 1935 0.0011

GLU 1935 GLU 1936 0.0004

GLU 1936 SER 1937 0.0002

SER 1937 ILE 1938 0.0007

ILE 1938 MET 1939 0.0009

MET 1939 GLY 1940 0.0007

GLY 1940 PHE 1941 0.0006

PHE 1941 GLU 1942 0.0005

GLU 1942 CYS 1943 0.0002

CYS 1943 ALA 1944 0.0004

ALA 1944 GLY 1945 0.0002

GLY 1945 VAL 1946 0.0006

VAL 1946 VAL 1947 0.0011

VAL 1947 ARG 1948 0.0007

ARG 1948 ARG 1949 -0.0109

ARG 1949 VAL 1950 0.0016

VAL 1950 GLY 1951 0.0019

GLY 1951 PRO 1952 0.0016

PRO 1952 SER 1953 0.0008

SER 1953 SER 1954 0.0018

SER 1954 ALA 1955 0.0006

ALA 1955 GLY 1956 0.0016

GLY 1956 HIS 1957 0.0006

HIS 1957 ASN 1958 0.0017

ASN 1958 ILE 1959 0.0019

ILE 1959 LYS 1960 0.0003

LYS 1960 VAL 1961 0.0016

VAL 1961 GLY 1962 0.0018

GLY 1962 ASP 1963 0.0007

ASP 1963 ARG 1964 0.0008

ARG 1964 VAL 1965 0.0020

VAL 1965 CYS 1966 0.0000

CYS 1966 ALA 1967 0.0014

ALA 1967 LEU 1968 0.0002

LEU 1968 LEU 1969 0.0017

LEU 1969 GLY 1970 0.0014

GLY 1970 GLY 1971 0.0014

GLY 1971 GLN 1972 0.0008

GLN 1972 TRP 1973 0.0016

TRP 1973 THR 1974 0.0003

THR 1974 ASN 1975 0.0001

ASN 1975 THR 1976 0.0016

THR 1976 VAL 1977 0.0012

VAL 1977 ARG 1978 0.0015

ARG 1978 VAL 1979 0.0011

VAL 1979 HIS 1980 0.0018

HIS 1980 TRP 1981 -0.0012

TRP 1981 HIS 1982 0.0002

HIS 1982 SER 1983 0.0016

SER 1983 VAL 1984 0.0006

VAL 1984 ALA 1985 0.0014

ALA 1985 PRO 1986 0.0007

PRO 1986 ILE 1987 0.0016

ILE 1987 PRO 1988 0.0013

PRO 1988 GLN 1989 0.0004

GLN 1989 ALA 1990 0.0014

ALA 1990 MET 1991 0.0008

MET 1991 ASP 1992 0.0015

ASP 1992 TRP 1993 0.0015

TRP 1993 GLU 1994 0.0003

GLU 1994 THR 1995 0.0015

THR 1995 ALA 1996 0.0014

ALA 1996 ALA 1997 0.0037

ALA 1997 SER 1998 0.0001

SER 1998 ILE 1999 0.0006

ILE 1999 PRO 2000 0.0007

PRO 2000 ILE 2001 0.0003

ILE 2001 VAL 2002 0.0004

VAL 2002 PHE 2003 0.0007

PHE 2003 VAL 2004 0.0008

VAL 2004 THR 2005 0.0003

THR 2005 ALA 2006 0.0007

ALA 2006 TYR 2007 0.0007

TYR 2007 ILE 2008 0.0006

ILE 2008 SER 2009 0.0004

SER 2009 LEU 2010 0.0007

LEU 2010 VAL 2011 0.0006

VAL 2011 LYS 2012 0.0009

LYS 2012 ILE 2013 -0.0087

ILE 2013 ALA 2014 0.0004

ALA 2014 ARG 2015 0.0002

ARG 2015 MET 2016 0.0002

MET 2016 GLN 2017 0.0005

GLN 2017 ALA 2018 0.0003

ALA 2018 GLY 2019 -0.0001

GLY 2019 GLU 2020 0.0003

GLU 2020 THR 2021 0.0002

THR 2021 VAL 2022 0.0002

VAL 2022 LEU 2023 0.0003

LEU 2023 ILE 2024 0.0002

ILE 2024 HIS 2025 0.0005

HIS 2025 ALA 2026 0.0001

ALA 2026 ALA 2027 0.0001

ALA 2027 SER 2028 0.0003

SER 2028 GLY 2029 0.0026

GLY 2029 GLY 2030 0.0002

GLY 2030 VAL 2031 0.0003

VAL 2031 GLY 2032 0.0004

GLY 2032 GLN 2033 0.0005

GLN 2033 ALA 2034 0.0004

ALA 2034 ALA 2035 0.0001

ALA 2035 ILE 2036 0.0006

ILE 2036 ILE 2037 0.0001

ILE 2037 LEU 2038 0.0007

LEU 2038 ALA 2039 -0.0001

ALA 2039 LYS 2040 0.0006

LYS 2040 HIS 2041 0.0003

HIS 2041 VAL 2042 0.0004

VAL 2042 GLY 2043 0.0005

GLY 2043 ALA 2044 0.0003

ALA 2044 GLU 2045 0.0095

GLU 2045 ILE 2046 0.0003

ILE 2046 PHE 2047 0.0004

PHE 2047 ALA 2048 0.0004

ALA 2048 THR 2049 0.0003

THR 2049 VAL 2050 0.0004

VAL 2050 GLY 2051 0.0005

GLY 2051 THR 2052 0.0003

THR 2052 ASP 2053 0.0004

ASP 2053 GLU 2054 -0.0000

GLU 2054 LYS 2055 0.0006

LYS 2055 ARG 2056 0.0003

ARG 2056 ASP 2057 0.0002

ASP 2057 LEU 2058 0.0000

LEU 2058 LEU 2059 0.0002

LEU 2059 ILE 2060 0.0002

ILE 2060 LYS 2061 -0.0034

LYS 2061 GLU 2062 0.0002

GLU 2062 TYR 2063 0.0004

TYR 2063 LYS 2064 0.0001

LYS 2064 ILE 2065 0.0001

ILE 2065 PRO 2066 0.0002

PRO 2066 ASP 2067 0.0004

ASP 2067 ASP 2068 0.0000

ASP 2068 HIS 2069 0.0004

HIS 2069 ILE 2070 0.0001

ILE 2070 PHE 2071 0.0002

PHE 2071 SER 2072 0.0005

SER 2072 SER 2073 0.0004

SER 2073 ARG 2074 0.0005

ARG 2074 ASN 2075 0.0001

ASN 2075 ALA 2076 0.0002

ALA 2076 LEU 2077 0.0022

LEU 2077 PHE 2078 0.0003

PHE 2078 ALA 2079 0.0003

ALA 2079 LYS 2080 0.0002

LYS 2080 SER 2081 0.0000

SER 2081 ILE 2082 0.0004

ILE 2082 ARG 2083 0.0001

ARG 2083 GLN 2084 0.0004

GLN 2084 ARG 2085 -0.0000

ARG 2085 THR 2086 0.0005

THR 2086 ASN 2087 0.0002

ASN 2087 GLY 2088 0.0001

GLY 2088 LYS 2089 0.0001

LYS 2089 GLY 2090 0.0002

GLY 2090 VAL 2091 0.0001

VAL 2091 ASP 2092 0.0005

ASP 2092 VAL 2093 -0.0012

VAL 2093 VAL 2094 0.0004

VAL 2094 LEU 2095 0.0002

LEU 2095 ASN 2096 0.0003

ASN 2096 CYS 2097 0.0004

CYS 2097 LEU 2098 0.0002

LEU 2098 ALA 2099 0.0004

ALA 2099 GLY 2100 -0.0001

GLY 2100 GLY 2101 0.0003

GLY 2101 LEU 2102 0.0001

LEU 2102 LEU 2103 0.0003

LEU 2103 GLN 2104 0.0001

GLN 2104 GLU 2105 0.0003

GLU 2105 SER 2106 0.0002

SER 2106 PHE 2107 0.0004

PHE 2107 ASP 2108 0.0002

ASP 2108 CYS 2109 -0.0051

CYS 2109 LEU 2110 0.0002

LEU 2110 ALA 2111 0.0004

ALA 2111 ASP 2112 0.0004

ASP 2112 PHE 2113 0.0002

PHE 2113 GLY 2114 0.0002

GLY 2114 ARG 2115 -0.0000

ARG 2115 PHE 2116 0.0002

PHE 2116 ILE 2117 0.0003

ILE 2117 GLU 2118 0.0005

GLU 2118 ILE 2119 -0.0001

ILE 2119 GLY 2120 0.0002

GLY 2120 LYS 2121 0.0003

LYS 2121 ARG 2122 0.0001

ARG 2122 ASP 2123 -0.0000

ASP 2123 ILE 2124 0.0003

ILE 2124 GLU 2125 -0.0179

GLU 2125 LEU 2126 0.0000

LEU 2126 ASN 2127 0.0003

ASN 2127 HIS 2128 0.0004

HIS 2128 CYS 2129 0.0002

CYS 2129 LEU 2130 0.0002

LEU 2130 ASN 2131 0.0003

ASN 2131 MET 2132 0.0002

MET 2132 GLY 2133 0.0004

GLY 2133 MET 2134 0.0002

MET 2134 PHE 2135 0.0004

PHE 2135 ALA 2136 0.0002

ALA 2136 ARG 2137 0.0002

ARG 2137 SER 2138 0.0001

SER 2138 ALA 2139 0.0003

ALA 2139 THR 2140 0.0003

THR 2140 PHE 2141 0.0027

PHE 2141 THR 2142 0.0004

THR 2142 ALA 2143 0.0007

ALA 2143 VAL 2144 0.0001

VAL 2144 ASP 2145 0.0008

ASP 2145 LEU 2146 0.0001

LEU 2146 ILE 2147 0.0008

ILE 2147 ALA 2148 0.0003

ALA 2148 ILE 2149 0.0006

ILE 2149 GLY 2150 0.0004

GLY 2150 ARG 2151 0.0004

ARG 2151 ASP 2152 0.0003

ASP 2152 ARG 2153 0.0006

ARG 2153 SER 2154 -0.0001

SER 2154 TYR 2155 0.0009

TYR 2155 MET 2156 0.0007

MET 2156 PHE 2157 0.0017

PHE 2157 ALA 2158 0.0005

ALA 2158 GLU 2159 0.0007

GLU 2159 ALA 2160 0.0008

ALA 2160 LEU 2161 0.0006

LEU 2161 PRO 2162 0.0005

PRO 2162 LYS 2163 0.0005

LYS 2163 ILE 2164 0.0011

ILE 2164 MET 2165 0.0001

MET 2165 THR 2166 0.0009

THR 2166 LEU 2167 0.0003

LEU 2167 LEU 2168 0.0008

LEU 2168 GLN 2169 0.0002

GLN 2169 GLU 2170 0.0009

GLU 2170 LYS 2171 0.0009

LYS 2171 ALA 2172 0.0003

ALA 2172 ILE 2173 0.0078

ILE 2173 ARG 2174 0.0014

ARG 2174 PRO 2175 0.0013

PRO 2175 VAL 2176 0.0004

VAL 2176 THR 2177 0.0012

THR 2177 PRO 2178 0.0013

PRO 2178 ILE 2179 0.0004

ILE 2179 SER 2180 0.0012

SER 2180 ILE 2181 0.0002

ILE 2181 TYR 2182 0.0010

TYR 2182 LYS 2183 0.0005

LYS 2183 ILE 2184 0.0012

ILE 2184 GLY 2185 0.0012

GLY 2185 ASP 2186 0.0003

ASP 2186 ILE 2187 0.0010

ILE 2187 GLU 2188 0.0007

GLU 2188 THR 2189 0.0074

THR 2189 ALA 2190 0.0013

ALA 2190 PHE 2191 0.0010

PHE 2191 ARG 2192 0.0006

ARG 2192 LEU 2193 0.0012

LEU 2193 MET 2194 0.0013

MET 2194 GLN 2195 0.0007

GLN 2195 ALA 2196 0.0009

ALA 2196 GLY 2197 0.0013

GLY 2197 LYS 2198 0.0011

LYS 2198 HIS 2199 0.0005

HIS 2199 MET 2200 0.0012

MET 2200 GLY 2201 0.0009

GLY 2201 LYS 2202 0.0008

LYS 2202 ILE 2203 0.0010

ILE 2203 VAL 2204 0.0001

VAL 2204 ILE 2205 0.0454

ILE 2205 THR 2206 0.0012

THR 2206 ALA 2207 0.0044

ALA 2207 PRO 2208 0.0038

PRO 2208 GLU 2209 0.0037

GLU 2209 ASP 2210 0.0041

ASP 2210 ALA 2211 0.0017

ALA 2211 MET 2212 0.0041

MET 2212 VAL 2213 0.0037

VAL 2213 PRO 2214 0.0036

PRO 2214 VAL 2215 0.0045

VAL 2215 ILE 2216 0.0051

ILE 2216 THR 2217 0.0033

THR 2217 ARG 2218 0.0057

ARG 2218 PRO 2219 0.0053

PRO 2219 PRO 2220 0.0029

PRO 2220 LYS 2221 0.1063

LYS 2221 LEU 2222 0.0299

LEU 2222 GLN 2223 0.0217

GLN 2223 LEU 2224 0.0265

LEU 2224 ARG 2225 0.0291

ARG 2225 PRO 2226 0.0023

PRO 2226 ASP 2227 0.0382

ASP 2227 ALA 2228 0.0338

ALA 2228 SER 2229 0.0378

SER 2229 TYR 2230 0.0249

TYR 2230 LEU 2231 0.0396

LEU 2231 ILE 2232 0.0387

ILE 2232 VAL 2233 0.0398

VAL 2233 GLY 2234 0.0373

GLY 2234 GLY 2235 0.0346

GLY 2235 LEU 2236 0.0249

LEU 2236 GLY 2237 0.0459

GLY 2237 GLY 2238 0.0328

GLY 2238 ILE 2239 0.0161

ILE 2239 GLY 2240 0.0258

GLY 2240 ARG 2241 0.0226

ARG 2241 SER 2242 0.0173

SER 2242 LEU 2243 0.0346

LEU 2243 CYS 2244 0.0060

CYS 2244 LYS 2245 0.0384

LYS 2245 ASN 2246 0.0063

ASN 2246 PHE 2247 0.0377

PHE 2247 VAL 2248 0.0102

VAL 2248 GLU 2249 0.0316

GLU 2249 ASN 2250 0.0180

ASN 2250 GLY 2251 0.0237

GLY 2251 ALA 2252 0.0342

ALA 2252 ARG 2253 0.0080

ARG 2253 SER 2254 0.0407

SER 2254 LEU 2255 0.0376

LEU 2255 VAL 2256 0.0411

VAL 2256 LEU 2257 0.0413

LEU 2257 LEU 2258 0.0400

LEU 2258 SER 2259 0.0398

SER 2259 ARG 2260 0.0392

ARG 2260 ASN 2261 0.0168

ASN 2261 ALA 2262 0.0361

ALA 2262 ASN 2263 0.0083

ASN 2263 VAL 2264 0.0386

VAL 2264 SER 2265 0.0351

SER 2265 GLN 2266 0.0351

GLN 2266 GLN 2267 0.0098

GLN 2267 SER 2268 0.0350

SER 2268 GLY 2269 0.0225

GLY 2269 GLU 2270 0.0363

GLU 2270 PHE 2271 0.0076

PHE 2271 LEU 2272 0.0332

LEU 2272 ASP 2273 0.0202

ASP 2273 GLU 2274 0.0185

GLU 2274 LEU 2275 0.0293

LEU 2275 ARG 2276 0.0130

ARG 2276 SER 2277 0.0370

SER 2277 THR 2278 0.0126

THR 2278 GLY 2279 0.0333

GLY 2279 CYS 2280 0.0249

CYS 2280 ILE 2281 0.0339

ILE 2281 VAL 2282 0.0374

VAL 2282 GLY 2283 0.0384

GLY 2283 VAL 2284 0.0388

VAL 2284 VAL 2285 0.0002

VAL 2285 ASP 2286 0.0427

ASP 2286 CYS 2287 0.0150

CYS 2287 ASP 2288 0.0230

ASP 2288 ILE 2289 0.0176

ILE 2289 SER 2290 0.0353

SER 2290 SER 2291 0.0208

SER 2291 LYS 2292 0.0409

LYS 2292 THR 2293 0.0036

THR 2293 GLN 2294 0.0385

GLN 2294 VAL 2295 0.0236

VAL 2295 GLU 2296 0.0406

GLU 2296 ALA 2297 0.0022

ALA 2297 THR 2298 0.0415

THR 2298 MET 2299 0.0309

MET 2299 LEU 2300 0.0210

LEU 2300 ARG 2301 0.0198

ARG 2301 LEU 2302 0.0295

LEU 2302 LYS 2303 0.0405

LYS 2303 LYS 2304 0.0009

LYS 2304 ASP 2305 0.0388

ASP 2305 MET 2306 0.0175

MET 2306 LEU 2307 0.0268

LEU 2307 PRO 2308 0.0128

PRO 2308 ILE 2309 0.0260

ILE 2309 ARG 2310 0.0133

ARG 2310 GLY 2311 0.0347

GLY 2311 ILE 2312 0.0417

ILE 2312 VAL 2313 0.0389

VAL 2313 HIS 2314 0.0416

HIS 2314 ALA 2315 0.0413

ALA 2315 GLY 2316 0.0359

GLY 2316 MET 2317 0.0302

MET 2317 VAL 2318 0.0519

VAL 2318 LEU 2319 0.0318

LEU 2319 GLN 2320 0.0510

GLN 2320 ASP 2321 0.0181

ASP 2321 SER 2322 0.0396

SER 2322 VAL 2323 0.0034

VAL 2323 PHE 2324 0.0500

PHE 2324 GLU 2325 0.0503

GLU 2325 ARG 2326 0.0072

ARG 2326 MET 2327 0.0413

MET 2327 SER 2328 0.0298

SER 2328 LEU 2329 0.0515

LEU 2329 ASP 2330 0.0097

ASP 2330 ASP 2331 0.0447

ASP 2331 TYR 2332 0.0295

TYR 2332 ASN 2333 0.0419

ASN 2333 THR 2334 0.0290

THR 2334 ALA 2335 0.0268

ALA 2335 ILE 2336 0.0391

ILE 2336 ARG 2337 0.0144

ARG 2337 PRO 2338 0.0441

PRO 2338 LYS 2339 0.0080

LYS 2339 VAL 2340 0.0440

VAL 2340 GLN 2341 0.0177

GLN 2341 GLY 2342 0.0337

GLY 2342 SER 2343 0.0263

SER 2343 TRP 2344 0.0468

TRP 2344 ASN 2345 0.0015

ASN 2345 LEU 2346 0.0472

LEU 2346 HIS 2347 0.0191

HIS 2347 SER 2348 0.0390

SER 2348 GLY 2349 0.0071

GLY 2349 LEU 2350 0.0401

LEU 2350 SER 2351 0.0275

SER 2351 ASP 2352 0.0234

ASP 2352 CYS 2353 0.0427

CYS 2353 ASP 2354 0.0306

ASP 2354 LEU 2355 0.0407

LEU 2355 ASP 2356 0.0373

ASP 2356 PHE 2357 0.0380

PHE 2357 PHE 2358 0.0427

PHE 2358 ILE 2359 0.0402

ILE 2359 MET 2360 0.0420

MET 2360 LEU 2361 0.0428

LEU 2361 SER 2362 0.0211

SER 2362 SER 2363 0.0354

SER 2363 LEU 2364 0.0101

LEU 2364 ALA 2365 0.0354

ALA 2365 GLY 2366 0.0471

GLY 2366 VAL 2367 0.0152

VAL 2367 SER 2368 0.0435

SER 2368 GLY 2369 0.0438

GLY 2369 SER 2370 0.0333

SER 2370 ALA 2371 0.0478

ALA 2371 SER 2372 0.0177

SER 2372 GLN 2373 0.0433

GLN 2373 ALA 2374 0.0382

ALA 2374 ASN 2375 0.0134

ASN 2375 TYR 2376 0.0459

TYR 2376 THR 2377 0.0061

THR 2377 ALA 2378 0.0484

ALA 2378 GLY 2379 0.0131

GLY 2379 GLY 2380 0.0411

GLY 2380 ALA 2381 0.0169

ALA 2381 TYR 2382 0.0298

TYR 2382 GLN 2383 0.0343

GLN 2383 ASP 2384 0.0108

ASP 2384 ALA 2385 0.0413

ALA 2385 LEU 2386 0.0093

LEU 2386 ALA 2387 0.0448

ALA 2387 LYS 2388 0.0100

LYS 2388 TYR 2389 0.0391

TYR 2389 ARG 2390 0.0188

ARG 2390 ARG 2391 0.0293

ARG 2391 ALA 2392 0.0285

ALA 2392 GLN 2393 0.0166

GLN 2393 GLY 2394 0.0436

GLY 2394 LEU 2395 0.0177

LEU 2395 SER 2396 0.0435

SER 2396 ALA 2397 0.0287

ALA 2397 VAL 2398 0.0377

VAL 2398 SER 2399 0.0398

SER 2399 ILE 2400 0.0400

ILE 2400 ASP 2401 0.0348

ASP 2401 LEU 2402 0.0234

LEU 2402 GLY 2403 0.0377

GLY 2403 MET 2404 0.0238

MET 2404 VAL 2405 0.0170

VAL 2405 GLN 2406 0.0369

GLN 2406 SER 2407 0.0076

SER 2407 VAL 2408 0.0337

VAL 2408 GLY 2409 0.0405

GLY 2409 TYR 2410 0.0374

TYR 2410 VAL 2411 0.0246

VAL 2411 ALA 2412 0.0228

ALA 2412 GLU 2413 -0.0027

GLU 2413 THR 2414 0.0338

THR 2414 LYS 2415 0.0424

LYS 2415 GLY 2416 0.0043

GLY 2416 VAL 2417 0.0379

VAL 2417 ALA 2418 0.0392

ALA 2418 GLU 2419 0.0336

GLU 2419 ARG 2420 0.0383

ARG 2420 LEU 2421 0.0409

LEU 2421 VAL 2422 0.0371

VAL 2422 ARG 2423 0.0337

ARG 2423 MET 2424 0.0410

MET 2424 GLY 2425 0.0384

GLY 2425 TYR 2426 0.0200

TYR 2426 SER 2427 0.0426

SER 2427 PRO 2428 0.0042

PRO 2428 ILE 2429 0.0499

ILE 2429 SER 2430 0.0128

SER 2430 GLU 2431 0.0147

GLU 2431 MET 2432 0.0278

MET 2432 GLU 2433 0.0048

GLU 2433 VAL 2434 0.0271

VAL 2434 LEU 2435 0.0231

LEU 2435 LYS 2436 0.0112

LYS 2436 ILE 2437 0.0223

ILE 2437 VAL 2438 0.0155

VAL 2438 GLU 2439 0.0314

GLU 2439 HIS 2440 0.0004

HIS 2440 ALA 2441 0.0317

ALA 2441 ILE 2442 0.0182

ILE 2442 THR 2443 0.0254

THR 2443 ASN 2444 0.0027

ASN 2444 PRO 2445 0.1634

PRO 2445 PRO 2446 0.0044

PRO 2446 PRO 2447 0.0364

PRO 2447 GLU 2448 0.0278

GLU 2448 ALA 2449 0.0392

ALA 2449 SER 2450 0.0202

SER 2450 SER 2451 0.0336

SER 2451 ALA 2452 0.0089

ALA 2452 GLN 2453 0.0407

GLN 2453 ILE 2454 0.0409

ILE 2454 ILE 2455 0.0361

ILE 2455 THR 2456 0.0358

THR 2456 GLY 2457 0.0415

GLY 2457 ILE 2458 0.0018

ILE 2458 SER 2459 0.0361

SER 2459 THR 2460 0.0166

THR 2460 LYS 2461 0.0531

LYS 2461 PRO 2462 0.0197

PRO 2462 GLY 2463 0.0409

GLY 2463 ARG 2464 0.0416

ARG 2464 HIS 2465 0.0353

HIS 2465 TRP 2466 0.0135

TRP 2466 THR 2467 0.0326

THR 2467 GLU 2468 0.0211

GLU 2468 SER 2469 0.0354

SER 2469 SER 2470 0.0336

SER 2470 TRP 2471 0.0379

TRP 2471 LEU 2472 0.0383

LEU 2472 GLN 2473 0.0076

GLN 2473 ASP 2474 0.0428

ASP 2474 ALA 2475 0.0282

ALA 2475 ARG 2476 0.0161

ARG 2476 PHE 2477 0.0503

PHE 2477 ALA 2478 0.0086

ALA 2478 THR 2479 0.0453

THR 2479 LEU 2480 0.0186

LEU 2480 ARG 2481 0.0356

ARG 2481 GLU 2482 0.0280

GLU 2482 ARG 2483 0.0213

ARG 2483 ALA 2484 0.0423

ALA 2484 ARG 2485 0.0096

ARG 2485 ASP 2486 0.0474

ASP 2486 VAL 2487 0.0100

VAL 2487 LYS 2488 0.0411

LYS 2488 GLU 2489 0.0136

GLU 2489 LEU 2490 0.0377

LEU 2490 SER 2491 0.0373

SER 2491 ASN 2492 0.0137

ASN 2492 SER 2493 0.0715

SER 2493 GLN 2494 0.0440

GLN 2494 ASN 989 0.0609

ASN 989 LYS 990 0.0024

LYS 990 ALA 991 0.0008

ALA 991 HIS 992 0.0016

HIS 992 ARG 993 0.0011

ARG 993 GLN 994 0.0014

GLN 994 ARG 995 0.0018

ARG 995 VAL 996 0.0019

VAL 996 HIS 997 0.0020

HIS 997 PRO 998 0.0015

PRO 998 PRO 999 0.0019

PRO 999 HIS 1000 0.0010

HIS 1000 ASP 1001 0.0025

ASP 1001 LEU 1002 0.0001

LEU 1002 LEU 1003 0.0022

LEU 1003 GLY 1004 0.0005

GLY 1004 SER 1005 -0.0197

SER 1005 LEU 1006 0.0015

LEU 1006 ILE 1007 0.0024

ILE 1007 VAL 1008 0.0017

VAL 1008 GLY 1009 0.0020

GLY 1009 ARG 1010 0.0000

ARG 1010 ASP 1011 0.0014

ASP 1011 LEU 1012 0.0024

LEU 1012 ARG 1013 0.0000

ARG 1013 GLU 1014 0.0023

GLU 1014 PRO 1015 0.0009

PRO 1015 THR 1016 0.0021

THR 1016 TRP 1017 0.0015

TRP 1017 ARG 1018 0.0015

ARG 1018 HIS 1019 0.0021

HIS 1019 PHE 1020 0.0016

PHE 1020 ILE 1021 -0.0502

ILE 1021 ARG 1022 0.0014

ARG 1022 VAL 1023 0.0024

VAL 1023 GLN 1024 0.0005

GLN 1024 ASP 1025 0.0025

ASP 1025 ILE 1026 0.0007

ILE 1026 PRO 1027 0.0026

PRO 1027 TRP 1028 0.0006

TRP 1028 ILE 1029 0.0022

ILE 1029 ARG 1030 0.0024

ARG 1030 ASP 1031 0.0012

ASP 1031 HIS 1032 0.0012

HIS 1032 VAL 1033 0.0023

VAL 1033 VAL 1034 0.0008

VAL 1034 GLN 1035 0.0026

GLN 1035 SER 1036 0.0004

SER 1036 ALA 1037 -0.0156

ALA 1037 LEU 1038 0.0016

LEU 1038 VAL 1039 0.0014

VAL 1039 TYR 1040 0.0022

TYR 1040 PRO 1041 0.0015

PRO 1041 GLY 1042 0.0009

GLY 1042 ALA 1043 0.0022

ALA 1043 GLY 1044 0.0007

GLY 1044 PHE 1045 0.0020

PHE 1045 ILE 1046 0.0019

ILE 1046 CYS 1047 0.0003

CYS 1047 MET 1048 0.0020

MET 1048 ALA 1049 0.0012

ALA 1049 MET 1050 0.0022

MET 1050 GLU 1051 -0.0001

GLU 1051 ALA 1052 0.0024

ALA 1052 MET 1053 -0.0008

MET 1053 VAL 1054 0.0009

VAL 1054 GLN 1055 0.0006

GLN 1055 LEU 1056 0.0013

LEU 1056 HIS 1057 0.0017

HIS 1057 GLU 1058 0.0001

GLU 1058 LEU 1059 0.0017

LEU 1059 ARG 1060 0.0009

ARG 1060 ASP 1061 0.0018

ASP 1061 SER 1062 0.0010

SER 1062 GLN 1063 0.0008

GLN 1063 SER 1064 0.0019

SER 1064 ARG 1065 0.0001

ARG 1065 LYS 1066 0.0018

LYS 1066 VAL 1067 0.0015

VAL 1067 ALA 1068 0.0009

ALA 1068 GLY 1069 0.0061

GLY 1069 TYR 1070 0.0020

TYR 1070 ARG 1071 0.0003

ARG 1071 LEU 1072 0.0018

LEU 1072 ALA 1073 0.0005

ALA 1073 GLU 1074 0.0017

GLU 1074 VAL 1075 0.0010

VAL 1075 ASP 1076 0.0020

ASP 1076 ILE 1077 0.0012

ILE 1077 LEU 1078 0.0022

LEU 1078 ARG 1079 0.0012

ARG 1079 ALA 1080 0.0012

ALA 1080 MET 1081 0.0001

MET 1081 LEU 1082 0.0016

LEU 1082 ILE 1083 0.0001

ILE 1083 PRO 1084 0.0012

PRO 1084 ASP 1085 0.0142

ASP 1085 THR 1086 0.0014

THR 1086 SER 1087 0.0010

SER 1087 GLU 1088 0.0015

GLU 1088 GLY 1089 0.0006

GLY 1089 LEU 1090 0.0005

LEU 1090 GLU 1091 0.0025

GLU 1091 ALA 1092 0.0008

ALA 1092 HIS 1093 0.0019

HIS 1093 ILE 1094 0.0016

ILE 1094 SER 1095 0.0018

SER 1095 LEU 1096 0.0017

LEU 1096 ARG 1097 0.0013

ARG 1097 PRO 1098 0.0016

PRO 1098 CYS 1099 0.0002

CYS 1099 SER 1100 0.0017

SER 1100 THR 1101 -0.0026

THR 1101 LYS 1102 0.0008

LYS 1102 LEU 1103 0.0017

LEU 1103 LEU 1104 0.0013

LEU 1104 LEU 1105 0.0011

LEU 1105 THR 1106 0.0018

THR 1106 ASN 1107 0.0002

ASN 1107 GLU 1108 0.0008

GLU 1108 TRP 1109 0.0020

TRP 1109 TYR 1110 0.0010

TYR 1110 ASP 1111 0.0017

ASP 1111 PHE 1112 0.0007

PHE 1112 CYS 1113 0.0015

CYS 1113 VAL 1114 0.0010

VAL 1114 SER 1115 0.0015

SER 1115 SER 1116 0.0008

SER 1116 VAL 1117 0.0057

VAL 1117 GLY 1118 0.0018

GLY 1118 ASP 1119 0.0009

ASP 1119 ASP 1120 0.0013

ASP 1120 ASP 1121 0.0018

ASP 1121 LYS 1122 0.0002

LYS 1122 PHE 1123 0.0015

PHE 1123 VAL 1124 0.0014

VAL 1124 ASP 1125 0.0011

ASP 1125 HIS 1126 0.0019

HIS 1126 CYS 1127 0.0014

CYS 1127 ARG 1128 0.0013

ARG 1128 GLY 1129 0.0014

GLY 1129 ARG 1130 0.0018

ARG 1130 ILE 1131 0.0012

ILE 1131 THR 1132 0.0020

THR 1132 ILE 1133 0.0069

ILE 1133 GLU 1134 0.0014

GLU 1134 PHE 1135 0.0013

PHE 1135 ASP 1136 0.0017

ASP 1136 THR 1137 0.0008

THR 1137 SER 1138 0.0015

SER 1138 GLY 1139 0.0002

GLY 1139 SER 1140 0.0011

SER 1140 ALA 1141 0.0016

ALA 1141 ASP 1142 0.0017

ASP 1142 THR 1143 0.0005

THR 1143 PRO 1144 0.0016

PRO 1144 ARG 1145 0.0017

ARG 1145 THR 1146 0.0010

THR 1146 SER 1147 0.0010

SER 1147 LEU 1148 0.0015

LEU 1148 ARG 1149 -0.0137

ARG 1149 GLU 1150 0.0006

GLU 1150 ARG 1151 0.0028

ARG 1151 SER 1152 0.0028

SER 1152 ARG 1153 0.0014

ARG 1153 SER 1154 0.0020

SER 1154 THR 1155 0.0027

THR 1155 GLY 1156 0.0025

GLY 1156 LEU 1157 0.0018

LEU 1157 MET 1158 0.0005

MET 1158 ARG 1159 0.0024

ARG 1159 SER 1160 0.0000

SER 1160 VAL 1161 0.0027

VAL 1161 ASP 1162 0.0003

ASP 1162 PRO 1163 0.0025

PRO 1163 SER 1164 0.0023

SER 1164 ASN 1165 0.0502

ASN 1165 LEU 1166 0.0018

LEU 1166 TYR 1167 0.0004

TYR 1167 SER 1168 0.0019

SER 1168 PHE 1169 0.0004

PHE 1169 LEU 1170 0.0018

LEU 1170 ARG 1171 0.0006

ARG 1171 ALA 1172 0.0011

ALA 1172 GLN 1173 0.0015

GLN 1173 GLY 1174 0.0006

GLY 1174 ILE 1175 0.0016

ILE 1175 TYR 1176 0.0007

TYR 1176 HIS 1177 0.0017

HIS 1177 GLY 1178 0.0001

GLY 1178 PRO 1179 0.0015

PRO 1179 ILE 1180 0.0018

ILE 1180 PHE 1181 -0.0045

PHE 1181 GLN 1182 0.0019

GLN 1182 ASN 1183 0.0025

ASN 1183 LEU 1184 0.0004

LEU 1184 LYS 1185 0.0023

LYS 1185 THR 1186 0.0005

THR 1186 ILE 1187 0.0004

ILE 1187 SER 1188 0.0005

SER 1188 SER 1189 0.0007

SER 1189 ARG 1190 0.0000

ARG 1190 LYS 1191 0.0012

LYS 1191 ASP 1192 0.0022

ASP 1192 HIS 1193 0.0005

HIS 1193 SER 1194 0.0003

SER 1194 GLU 1195 0.0010

GLU 1195 SER 1196 0.0007

SER 1196 SER 1197 -0.0082

SER 1197 PHE 1198 0.0005

PHE 1198 VAL 1199 0.0000

VAL 1199 VAL 1200 0.0014

VAL 1200 ALA 1201 0.0011

ALA 1201 ASN 1202 0.0000

ASN 1202 THR 1203 0.0020

THR 1203 ALA 1204 0.0002

ALA 1204 SER 1205 0.0020

SER 1205 VAL 1206 0.0022

VAL 1206 MET 1207 0.0018

MET 1207 PRO 1208 0.0000

PRO 1208 ASN 1209 0.0014

ASN 1209 GLY 1210 0.0007

GLY 1210 PHE 1211 0.0022

PHE 1211 GLN 1212 0.0004

GLN 1212 SER 1213 0.0081

SER 1213 PRO 1214 0.0018

PRO 1214 HIS 1215 -0.0000

HIS 1215 VAL 1216 0.0004

VAL 1216 ILE 1217 0.0020

ILE 1217 HIS 1218 0.0023

HIS 1218 PRO 1219 0.0019

PRO 1219 THR 1220 0.0027

THR 1220 THR 1221 0.0021

THR 1221 LEU 1222 0.0012

LEU 1222 ASP 1223 0.0024

ASP 1223 SER 1224 0.0026

SER 1224 ILE 1225 0.0010

ILE 1225 PHE 1226 0.0023

PHE 1226 GLN 1227 0.0024

GLN 1227 GLY 1228 0.0018

GLY 1228 ALA 1229 -0.0018

ALA 1229 TYR 1230 0.0017

TYR 1230 THR 1231 0.0023

THR 1231 ALA 1232 0.0009

ALA 1232 LEU 1233 0.0014

LEU 1233 PRO 1234 0.0012

PRO 1234 GLY 1235 0.0018

GLY 1235 ALA 1236 0.0008

ALA 1236 GLY 1237 0.0023

GLY 1237 LEU 1238 0.0022

LEU 1238 ASP 1239 0.0005

ASP 1239 GLN 1240 0.0020

GLN 1240 ASN 1241 0.0019

ASN 1241 THR 1242 0.0010

THR 1242 ALA 1243 0.0003

ALA 1243 MET 1244 0.0024

MET 1244 ILE 1245 0.0144

ILE 1245 PRO 1246 0.0023

PRO 1246 ARG 1247 0.0018

ARG 1247 SER 1248 0.0019

SER 1248 ILE 1249 0.0020

ILE 1249 GLN 1250 0.0013

GLN 1250 GLU 1251 0.0015

GLU 1251 LEU 1252 0.0007

LEU 1252 TYR 1253 0.0018

TYR 1253 LEU 1254 0.0003

LEU 1254 SER 1255 0.0019

SER 1255 SER 1256 0.0003

SER 1256 ALA 1257 0.0020

ALA 1257 LEU 1258 0.0022

LEU 1258 THR 1259 0.0004

THR 1259 SER 1260 0.0018

SER 1260 ASP 1261 0.0030

ASP 1261 VAL 1262 0.0017

VAL 1262 GLY 1263 0.0013

GLY 1263 GLN 1264 0.0010

GLN 1264 CYS 1265 0.0003

CYS 1265 LEU 1266 0.0009

LEU 1266 VAL 1267 -0.0001

VAL 1267 SER 1268 0.0010

SER 1268 ASP 1269 0.0002

ASP 1269 THR 1270 0.0015

THR 1270 SER 1271 0.0002

SER 1271 LEU 1272 0.0014

LEU 1272 ILE 1273 0.0012

ILE 1273 ARG 1274 0.0019

ARG 1274 TYR 1275 0.0017

TYR 1275 ASP 1276 0.0016

ASP 1276 GLY 1277 -0.0110

GLY 1277 GLN 1278 0.0012

GLN 1278 SER 1279 0.0019

SER 1279 PHE 1280 0.0017

PHE 1280 THR 1281 0.0020

THR 1281 VAL 1282 0.0016

VAL 1282 ASN 1283 0.0019

ASN 1283 VAL 1284 0.0007

VAL 1284 ASP 1285 0.0018

ASP 1285 VAL 1286 0.0003

VAL 1286 SER 1287 0.0017

SER 1287 SER 1288 0.0007

SER 1288 LYS 1289 0.0021

LYS 1289 ALA 1290 0.0012

ALA 1290 ASP 1291 0.0012

ASP 1291 SER 1292 0.0009

SER 1292 GLU 1293 0.0019

GLU 1293 HIS 1294 0.0019

HIS 1294 THR 1295 0.0019

THR 1295 PRO 1296 0.0020

PRO 1296 VAL 1297 0.0003

VAL 1297 LEU 1298 0.0017

LEU 1298 GLU 1299 0.0003

GLU 1299 ILE 1300 0.0018

ILE 1300 LYS 1301 0.0002

LYS 1301 GLY 1302 0.0019

GLY 1302 LEU 1303 0.0010

LEU 1303 ARG 1304 0.0018

ARG 1304 ASN 1305 0.0017

ASN 1305 GLN 1306 0.0019

GLN 1306 SER 1307 0.0021

SER 1307 VAL 1308 0.0008

VAL 1308 GLY 1309 0.1082

GLY 1309 GLN 1310 0.0093

GLN 1310 MET 1311 0.0158

MET 1311 ALA 1312 0.0023

ALA 1312 PRO 1313 0.0149

PRO 1313 GLN 1314 0.0155

GLN 1314 PRO 1315 0.0036

PRO 1315 GLY 1316 0.0155

GLY 1316 ASP 1317 0.0116

ASP 1317 SER 1318 0.0063

SER 1318 SER 1319 0.0156

SER 1319 ASN 1320 0.0084

ASN 1320 ASN 1321 0.0086

ASN 1321 ASP 1322 0.0104

ASP 1322 LEU 1323 0.0127

LEU 1323 CYS 1324 0.0035

CYS 1324 PHE 1325 0.0925

PHE 1325 LYS 1326 0.0506

LYS 1326 LEU 1327 0.0387

LEU 1327 ASP 1328 0.0222

ASP 1328 TRP 1329 0.0398

TRP 1329 ALA 1330 0.0081

ALA 1330 PRO 1331 0.0227

PRO 1331 ASP 1332 0.0376

ASP 1332 ILE 1333 0.0158

ILE 1333 SER 1334 0.0431

SER 1334 SER 1335 0.0523

SER 1335 VAL 1336 0.0564

VAL 1336 LYS 1337 0.0399

LYS 1337 GLN 1338 0.0357

GLN 1338 GLU 1339 0.0519

GLU 1339 ARG 1340 0.0078

ARG 1340 LEU 1341 -0.0102

LEU 1341 LYS 1342 0.0532

LYS 1342 GLU 1343 0.0272

GLU 1343 LYS 1344 0.0454

LYS 1344 PHE 1345 0.0463

PHE 1345 GLY 1346 0.0402

GLY 1346 PHE 1347 0.0713

PHE 1347 PRO 1348 0.0694

PRO 1348 LEU 1349 0.0414

LEU 1349 ASP 1350 0.0586

ASP 1350 PRO 1351 0.0604

PRO 1351 THR 1352 0.0702

THR 1352 GLU 1353 0.0517

GLU 1353 ALA 1354 0.0350

ALA 1354 ASP 1355 0.0705

ASP 1355 ILE 1356 0.0709

ILE 1356 ILE 1357 0.0537

ILE 1357 MET 1358 0.0549

MET 1358 GLY 1359 0.0720

GLY 1359 LEU 1360 0.0653

LEU 1360 ARG 1361 0.0273

ARG 1361 GLN 1362 0.0702

GLN 1362 ALA 1363 0.0715

ALA 1363 CYS 1364 0.0463

CYS 1364 ILE 1365 0.0379

ILE 1365 HIS 1366 0.0720

HIS 1366 PHE 1367 0.0718

PHE 1367 ILE 1368 0.0325

ILE 1368 HIS 1369 0.0583

HIS 1369 ARG 1370 0.0720

ARG 1370 SER 1371 0.0656

SER 1371 LEU 1372 0.0290

LEU 1372 GLN 1373 0.0694

GLN 1373 SER 1374 0.0722

SER 1374 LEU 1375 0.0567

LEU 1375 THR 1376 0.0104

THR 1376 ALA 1377 0.0308

ALA 1377 PRO 1378 0.0725

PRO 1378 ASP 1379 0.0029

ASP 1379 ARG 1380 0.0700

ARG 1380 ASP 1381 0.0392

ASP 1381 GLN 1382 0.0430

GLN 1382 LEU 1383 0.0376

LEU 1383 ASP 1384 0.0676

ASP 1384 TRP 1385 0.0715

TRP 1385 HIS 1386 0.0080

HIS 1386 GLN 1387 0.0726

GLN 1387 LYS 1388 0.0266

LYS 1388 ARG 1389 0.0492

ARG 1389 PHE 1390 0.0370

PHE 1390 TYR 1391 0.0386

TYR 1391 ASP 1392 0.0665

ASP 1392 TRP 1393 0.0071

TRP 1393 MET 1394 0.0720

MET 1394 VAL 1395 0.0266

VAL 1395 LEU 1396 0.0651

LEU 1396 GLN 1397 0.0165

GLN 1397 ILE 1398 0.0598

ILE 1398 GLN 1399 0.0539

GLN 1399 LEU 1400 0.0233

LEU 1400 ALA 1401 0.0599

ALA 1401 GLU 1402 0.0317

GLU 1402 GLU 1403 0.0729

GLU 1403 ASP 1404 0.0041

ASP 1404 ARG 1405 0.0712

ARG 1405 LEU 1406 0.0450

LEU 1406 ALA 1407 0.0447

ALA 1407 PRO 1408 0.0729

PRO 1408 ASN 1409 0.0582

ASN 1409 SER 1410 0.0699

SER 1410 SER 1411 0.0203

SER 1411 ALA 1412 0.0513

ALA 1412 TRP 1413 0.0657

TRP 1413 LEU 1414 0.0138

LEU 1414 GLN 1415 0.0721

GLN 1415 CYS 1416 0.0197

CYS 1416 SER 1417 0.0714

SER 1417 SER 1418 0.0711

SER 1418 SER 1419 0.0118

SER 1419 ASP 1420 0.0696

ASP 1420 GLU 1421 0.0667

GLU 1421 GLN 1422 0.0495

GLN 1422 LYS 1423 0.0257

LYS 1423 LEU 1424 0.0685

LEU 1424 LEU 1425 0.0717

LEU 1425 GLU 1426 0.0190

GLU 1426 ASN 1427 0.0573

ASN 1427 VAL 1428 0.0593

VAL 1428 ARG 1429 0.0695

ARG 1429 ALA 1430 0.0067

ALA 1430 SER 1431 0.0723

SER 1431 SER 1432 0.0707

SER 1432 VAL 1433 0.0674

VAL 1433 ASN 1434 0.0239

ASN 1434 GLY 1435 0.0707

GLY 1435 GLN 1436 0.0706

GLN 1436 MET 1437 0.0394

MET 1437 VAL 1438 0.0401

VAL 1438 VAL 1439 0.0716

VAL 1439 HIS 1440 0.0721

HIS 1440 VAL 1441 0.0275

VAL 1441 GLY 1442 0.0582

GLY 1442 LYS 1443 0.0722

LYS 1443 SER 1444 0.0587

SER 1444 MET 1445 0.0471

MET 1445 LEU 1446 0.0232

LEU 1446 ALA 1447 0.0685

ALA 1447 ILE 1448 0.0705

ILE 1448 LEU 1449 0.0175

LEU 1449 ARG 1450 0.0604

ARG 1450 HIS 1451 0.0586

HIS 1451 GLU 1452 0.0528

GLU 1452 ILE 1453 0.0318

ILE 1453 ALA 1454 0.0678

ALA 1454 PRO 1455 0.0577

PRO 1455 LEU 1456 0.0431

LEU 1456 GLU 1457 0.0650

GLU 1457 LEU 1458 0.0705

LEU 1458 MET 1459 0.0510

MET 1459 LEU 1460 0.0510

LEU 1460 GLN 1461 0.0678

GLN 1461 ASP 1462 0.0042

ASP 1462 LYS 1463 0.0713

LYS 1463 LEU 1464 0.0629

LEU 1464 LEU 1465 0.0598

LEU 1465 TYR 1466 0.0179

TYR 1466 ARG 1467 0.0583

ARG 1467 TYR 1468 0.0345

TYR 1468 TYR 1469 0.0805

TYR 1469 THR 1470 0.0036

THR 1470 ASP 1471 0.0684

ASP 1471 ALA 1472 0.0227

ALA 1472 ILE 1473 0.0690

ILE 1473 LYS 1474 0.0689

LYS 1474 TRP 1475 0.0665

TRP 1475 ASP 1476 0.0005

ASP 1476 ARG 1477 0.0690

ARG 1477 SER 1478 0.0442

SER 1478 TYR 1479 0.0466

TYR 1479 GLN 1480 0.0251

GLN 1480 GLN 1481 0.0534

GLN 1481 ILE 1482 0.0664

ILE 1482 ASP 1483 0.0074

ASP 1483 GLN 1484 0.0630

GLN 1484 LEU 1485 0.0334

LEU 1485 VAL 1486 0.0604

VAL 1486 LYS 1487 0.0028

LYS 1487 LEU 1488 0.0616

LEU 1488 HIS 1489 0.0420

HIS 1489 ALA 1490 0.0374

ALA 1490 HIS 1491 0.0295

HIS 1491 LYS 1492 0.0456

LYS 1492 CYS 1493 0.0550

CYS 1493 PRO 1494 0.0413

PRO 1494 THR 1495 0.0493

THR 1495 ALA 1496 0.0119

ALA 1496 LYS 1497 0.0329

LYS 1497 ILE 1498 0.0533

ILE 1498 ILE 1499 0.0190

ILE 1499 GLU 1500 0.0586

GLU 1500 ILE 1501 0.0038

ILE 1501 GLY 1502 0.0654

GLY 1502 ALA 1503 0.0079

ALA 1503 GLY 1504 0.0615

GLY 1504 THR 1505 0.0345

THR 1505 GLY 1506 0.0395

GLY 1506 GLY 1507 0.0682

GLY 1507 CYS 1508 0.0681

CYS 1508 THR 1509 0.0549

THR 1509 ARG 1510 0.0246

ARG 1510 ALA 1511 0.0677

ALA 1511 VAL 1512 0.0663

VAL 1512 LEU 1513 0.0418

LEU 1513 ASP 1514 0.0369

ASP 1514 ALA 1515 0.0672

ALA 1515 LEU 1516 0.0683

LEU 1516 SER 1517 0.0362

SER 1517 ASN 1518 0.0154

ASN 1518 GLN 1519 0.0377

GLN 1519 GLY 1520 0.0499

GLY 1520 ILE 1521 0.0596

ILE 1521 ALA 1522 0.0045

ALA 1522 ARG 1523 0.0591

ARG 1523 CYS 1524 0.0211

CYS 1524 ALA 1525 0.0605

ALA 1525 GLN 1526 0.0323

GLN 1526 TYR 1527 0.0490

TYR 1527 ASP 1528 0.0126

ASP 1528 PHE 1529 0.0599

PHE 1529 THR 1530 0.0010

THR 1530 ASP 1531 0.0320

ASP 1531 VAL 1532 0.0074

VAL 1532 SER 1533 0.0583

SER 1533 SER 1534 0.0253

SER 1534 GLY 1535 0.0678

GLY 1535 PHE 1536 0.0296

PHE 1536 PHE 1537 0.0492

PHE 1537 GLU 1538 0.0506

GLU 1538 ALA 1539 0.0637

ALA 1539 ALA 1540 0.0651

ALA 1540 GLN 1541 0.0492

GLN 1541 GLN 1542 0.0495

GLN 1542 LYS 1543 0.0679

LYS 1543 PHE 1544 0.0631

PHE 1544 ALA 1545 0.0499

ALA 1545 ALA 1546 0.0313

ALA 1546 PHE 1547 0.0479

PHE 1547 ASP 1548 0.0593

ASP 1548 ASP 1549 0.0912

ASP 1549 VAL 1550 0.0460

VAL 1550 ILE 1551 0.0276

ILE 1551 ARG 1552 0.0278

ARG 1552 PHE 1553 0.0328

PHE 1553 GLN 1554 0.0101

GLN 1554 LYS 1555 0.0085

LYS 1555 LEU 1556 0.0528

LEU 1556 ASP 1557 0.0087

ASP 1557 ILE 1558 0.0685

ILE 1558 GLU 1559 0.0002

GLU 1559 LYS 1560 0.0684

LYS 1560 ASP 1561 0.0630

ASP 1561 ILE 1562 0.0003

ILE 1562 GLU 1563 0.0670

GLU 1563 MET 1564 0.0484

MET 1564 GLN 1565 0.0377

GLN 1565 GLY 1566 0.0254

GLY 1566 PHE 1567 0.0593

PHE 1567 GLU 1568 0.0637

GLU 1568 CYS 1569 0.0552

CYS 1569 GLY 1570 0.0444

GLY 1570 SER 1571 0.0238

SER 1571 TYR 1572 0.0632

TYR 1572 ASP 1573 0.0470

ASP 1573 LEU 1574 0.0648

LEU 1574 VAL 1575 0.0258

VAL 1575 ILE 1576 0.0673

ILE 1576 ALA 1577 0.0259

ALA 1577 SER 1578 0.0670

SER 1578 GLN 1579 0.0244

GLN 1579 VAL 1580 0.0498

VAL 1580 LEU 1581 0.0483

LEU 1581 HIS 1582 0.0474

HIS 1582 ALA 1583 0.0620

ALA 1583 THR 1584 0.0526

THR 1584 GLY 1585 0.0043

GLY 1585 LYS 1586 0.0693

LYS 1586 MET 1587 0.0224

MET 1587 GLU 1588 0.0687

GLU 1588 HIS 1589 0.0694

HIS 1589 THR 1590 0.0262

THR 1590 MET 1591 0.0508

MET 1591 ALA 1592 0.0638

ALA 1592 ASN 1593 0.0602

ASN 1593 VAL 1594 0.0219

VAL 1594 ARG 1595 0.0693

ARG 1595 LYS 1596 0.0697

LYS 1596 LEU 1597 0.0128

LEU 1597 LEU 1598 0.0491

LEU 1598 LYS 1599 0.0560

LYS 1599 PRO 1600 0.0661

PRO 1600 GLY 1601 0.0474

GLY 1601 GLY 1602 0.0679

GLY 1602 LYS 1603 0.0686

LYS 1603 LEU 1604 0.0416

LEU 1604 LEU 1605 0.0599

LEU 1605 LEU 1606 0.0352

LEU 1606 VAL 1607 0.0684

VAL 1607 GLU 1608 0.0108

GLU 1608 THR 1609 0.0534

THR 1609 THR 1610 0.0632

THR 1610 ARG 1611 0.0632

ARG 1611 ASP 1612 0.0607

ASP 1612 GLU 1613 0.0624

GLU 1613 MET 1614 0.0509

MET 1614 ASP 1615 0.0454

ASP 1615 LEU 1616 0.0719

LEU 1616 GLN 1617 0.0009

GLN 1617 LEU 1618 0.0706

LEU 1618 VAL 1619 0.0453

VAL 1619 PHE 1620 0.0665

PHE 1620 GLY 1621 0.0076

GLY 1621 LEU 1622 0.0689

LEU 1622 LEU 1623 0.0689

LEU 1623 PRO 1624 0.0388

PRO 1624 GLY 1625 0.0410

GLY 1625 TRP 1626 0.0718

TRP 1626 TRP 1627 0.0063

TRP 1627 LEU 1628 0.0716

LEU 1628 SER 1629 0.0662

SER 1629 SER 1630 0.0165

SER 1630 GLU 1631 0.0662

GLU 1631 GLU 1632 0.0556

GLU 1632 GLU 1633 0.0227

GLU 1633 ARG 1634 0.0580

ARG 1634 GLN 1635 0.0345

GLN 1635 MET 1636 0.0602

MET 1636 SER 1637 0.0086

SER 1637 PRO 1638 0.0578

PRO 1638 SER 1639 0.0425

SER 1639 LEU 1640 0.0707

LEU 1640 SER 1641 0.0627

SER 1641 THR 1642 0.0327

THR 1642 ASN 1643 0.0420

ASN 1643 SER 1644 0.0467

SER 1644 TRP 1645 0.0208

TRP 1645 GLU 1646 0.0654

GLU 1646 LYS 1647 0.0103

LYS 1647 VAL 1648 0.0687

VAL 1648 LEU 1649 0.0140

LEU 1649 LYS 1650 0.0635

LYS 1650 LYS 1651 0.0206

LYS 1651 THR 1652 0.0539

THR 1652 GLY 1653 0.0376

GLY 1653 PHE 1654 0.0335

PHE 1654 ASP 1655 0.0625

ASP 1655 GLY 1656 0.0667

GLY 1656 LEU 1657 0.0429

LEU 1657 ASP 1658 0.0082

ASP 1658 ILE 1659 0.0613

ILE 1659 GLU 1660 0.0580

GLU 1660 LEU 1661 0.0490

LEU 1661 ARG 1662 0.0593

ARG 1662 ASP 1663 0.0624

ASP 1663 CYS 1664 0.0693

CYS 1664 ASP 1665 0.0698

ASP 1665 SER 1666 0.0279

SER 1666 ASP 1667 0.0090

ASP 1667 GLU 1668 0.0639

GLU 1668 PHE 1669 0.0498

PHE 1669 TYR 1670 0.0674

TYR 1670 SER 1671 0.0552

SER 1671 PHE 1672 0.0542

PHE 1672 SER 1673 0.0668

SER 1673 VAL 1674 0.0399

VAL 1674 MET 1675 0.0591

MET 1675 MET 1676 0.0614

MET 1676 ALA 1677 0.0701

ALA 1677 THR 1678 0.0545

THR 1678 ALA 1679 0.0475

ALA 1679 SER 1680 0.0577

SER 1680 SER 1681 0.0402

SER 1681 THR 1682 0.0582

THR 1682 ILE 1683 0.0251

ILE 1683 ALA 1684 0.0601

ALA 1684 SER 1685 0.0592

SER 1685 SER 1686 0.0131

SER 1686 SER 1687 0.0583

SER 1687 MET 1688 0.0058

MET 1688 ALA 1689 0.0424

ALA 1689 PHE 1690 0.0446

PHE 1690 ALA 1691 0.0205

ALA 1691 ILE 1692 0.0506

ILE 1692 VAL 1693 -0.0090

VAL 1693 TYR 1694 0.0363

TYR 1694 GLY 1695 0.0005

GLY 1695 GLU 1696 0.0353

GLU 1696 VAL 1697 0.0391

VAL 1697 PRO 1698 0.0087

PRO 1698 LEU 1699 0.0241

LEU 1699 PRO 1700 0.0402

PRO 1700 ASP 1701 0.0262

ASP 1701 GLN 1702 0.0291

GLN 1702 PHE 1703 0.0505

PHE 1703 LEU 1704 0.0547

LEU 1704 ASP 1705 0.0086

ASP 1705 ASP 1706 0.0485

ASP 1706 MET 1707 0.0445

MET 1707 LYS 1708 0.0462

LYS 1708 THR 1709 0.0154

THR 1709 ALA 1710 0.0551

ALA 1710 ILE 1711 0.0509

ILE 1711 SER 1712 0.0291

SER 1712 SER 1713 0.0298

SER 1713 SER 1714 0.0498

SER 1714 ALA 1715 0.0533

ALA 1715 VAL 1716 0.0459

VAL 1716 SER 1717 0.0249

SER 1717 ASP 1718 0.0448

ASP 1718 PRO 1719 0.0050

PRO 1719 VAL 1720 0.0256

VAL 1720 VAL 1721 0.0318

VAL 1721 GLY 1722 0.0051

GLY 1722 HIS 1723 0.0040

HIS 1723 LEU 1724 0.0438

LEU 1724 ASP 1725 0.0327

ASP 1725 SER 1726 0.0234

SER 1726 ILE 1727 0.0208

ILE 1727 ASP 1728 0.0480

ASP 1728 ALA 1729 0.0524

ALA 1729 THR 1730 0.0507

THR 1730 GLY 1731 0.0170

GLY 1731 LYS 1732 0.0525

LYS 1732 PHE 1733 0.0543

PHE 1733 CYS 1734 0.0288

CYS 1734 ILE 1735 0.0540

ILE 1735 PHE 1736 0.0048

PHE 1736 ILE 1737 0.0536

ILE 1737 GLU 1738 0.0039

GLU 1738 ASP 1739 0.0482

ASP 1739 PRO 1740 0.0502

PRO 1740 GLU 1741 0.0014

GLU 1741 THR 1742 0.0486

THR 1742 ASP 1743 0.0504

ASP 1743 ILE 1744 0.0534

ILE 1744 LEU 1745 0.0494

LEU 1745 SER 1746 0.0250

SER 1746 SER 1747 0.0371

SER 1747 PRO 1748 0.0409

PRO 1748 ASP 1749 0.0471

ASP 1749 GLU 1750 0.0535

GLU 1750 LYS 1751 0.0187

LYS 1751 SER 1752 0.0379

SER 1752 TYR 1753 0.0506

TYR 1753 ALA 1754 0.0496

ALA 1754 SER 1755 0.0152

SER 1755 ILE 1756 0.0516

ILE 1756 GLN 1757 0.0591

GLN 1757 LYS 1758 0.0315

LYS 1758 LEU 1759 0.0283

LEU 1759 VAL 1760 0.0534

VAL 1760 THR 1761 0.0533

THR 1761 ARG 1762 0.0252

ARG 1762 CYS 1763 0.0296

CYS 1763 LYS 1764 0.0219

LYS 1764 GLY 1765 0.0522

GLY 1765 LEU 1766 0.0422

LEU 1766 ILE 1767 0.0524

ILE 1767 TRP 1768 0.0120

TRP 1768 VAL 1769 0.0524

VAL 1769 SER 1770 0.0275

SER 1770 ARG 1771 0.0524

ARG 1771 GLY 1772 0.0424

GLY 1772 GLY 1773 0.0587

GLY 1773 ALA 1774 0.0354

ALA 1774 MET 1775 0.0474

MET 1775 HIS 1776 0.0302

HIS 1776 GLY 1777 0.0282

GLY 1777 THR 1778 0.0504

THR 1778 ARG 1779 0.0445

ARG 1779 PRO 1780 0.0368

PRO 1780 ASN 1781 0.0497

ASN 1781 SER 1782 0.0013

SER 1782 SER 1783 0.0503

SER 1783 LEU 1784 0.0365

LEU 1784 LYS 1785 0.0154

LYS 1785 THR 1786 0.0414

THR 1786 GLY 1787 0.0213

GLY 1787 LEU 1788 0.0502

LEU 1788 LEU 1789 -0.0034

LEU 1789 ARG 1790 0.0518

ARG 1790 THR 1791 0.0357

THR 1791 LEU 1792 0.0356

LEU 1792 ARG 1793 0.0202

ARG 1793 LEU 1794 0.0391

LEU 1794 GLU 1795 0.0475

GLU 1795 TYR 1796 0.0102

TYR 1796 THR 1797 0.0285

THR 1797 GLU 1798 0.0257

GLU 1798 LYS 1799 0.0509

LYS 1799 ARG 1800 0.0475

ARG 1800 PHE 1801 0.0222

PHE 1801 ILE 1802 0.0487

ILE 1802 SER 1803 0.0352

SER 1803 LEU 1804 0.0414

LEU 1804 ASP 1805 0.0515

ASP 1805 LEU 1806 0.0440

LEU 1806 ASP 1807 0.0552

ASP 1807 SER 1808 0.0153

SER 1808 ALA 1809 0.0485

ALA 1809 ARG 1810 0.0257

ARG 1810 PRO 1811 0.0555

PRO 1811 GLN 1812 0.0504

GLN 1812 TRP 1813 0.0218

TRP 1813 ASN 1814 0.0167

ASN 1814 HIS 1815 0.0081

HIS 1815 ASP 1816 0.0543

ASP 1816 SER 1817 0.0256

SER 1817 ILE 1818 0.0352

ILE 1818 THR 1819 0.0304

THR 1819 THR 1820 0.0308

THR 1820 ILE 1821 0.0591

ILE 1821 ASN 1822 0.0065

ASN 1822 GLU 1823 0.0559

GLU 1823 VAL 1824 0.0243

VAL 1824 LEU 1825 0.0540

LEU 1825 CYS 1826 0.0069

CYS 1826 GLY 1827 0.0515

GLY 1827 ALA 1828 0.0405

ALA 1828 LEU 1829 0.0222

LEU 1829 ALA 1830 0.0280

ALA 1830 GLN 1831 0.0498

GLN 1831 ASN 1832 0.0427

ASN 1832 ALA 1833 0.0475

ALA 1833 ASP 1834 0.0581

ASP 1834 SER 1835 0.0433

SER 1835 SER 1836 0.0199

SER 1836 ILE 1837 0.0371

ILE 1837 LYS 1838 0.0549

LYS 1838 ASP 1839 0.0440

ASP 1839 SER 1840 0.0306

SER 1840 GLU 1841 0.0448

GLU 1841 PHE 1842 0.0446

PHE 1842 ALA 1843 0.0512

ALA 1843 GLU 1844 0.0424

GLU 1844 GLN 1845 0.0549

GLN 1845 ASP 1846 0.0405

ASP 1846 GLY 1847 0.0314

GLY 1847 GLN 1848 0.0554

GLN 1848 LEU 1849 0.0524

LEU 1849 PHE 1850 0.0353

PHE 1850 VAL 1851 0.0533

VAL 1851 PRO 1852 0.0199

PRO 1852 ARG 1853 0.1399

ARG 1853 ILE 1854 0.0098

ILE 1854 SER 1855 0.0245

SER 1855 CYS 1856 0.0170

CYS 1856 ASP 1857 0.0196

ASP 1857 ILE 1858 0.0233

ILE 1858 ALA 1859 0.0214

ALA 1859 ARG 1860 0.0049

ARG 1860 ASN 1861 0.0250

ASN 1861 GLU 1862 0.0236

GLU 1862 ASP 1863 0.0101

ASP 1863 LEU 1864 0.0161

LEU 1864 SER 1865 0.0226

SER 1865 SER 1866 0.0249

SER 1866 ASP 1867 0.0046

ASP 1867 SER 1868 0.0205

SER 1868 ASN 1869 -0.1612

ASN 1869 SER 1870 0.0018

SER 1870 PRO 1871 0.0027

PRO 1871 ALA 1872 0.0033

ALA 1872 GLN 1873 0.0023

GLN 1873 MET 1874 0.0037

MET 1874 GLU 1875 0.0009

GLU 1875 PRO 1876 0.0033

PRO 1876 PHE 1877 0.0036

PHE 1877 HIS 1878 0.0007

HIS 1878 GLN 1879 0.0017

GLN 1879 PRO 1880 0.0004

PRO 1880 GLY 1881 0.0036

GLY 1881 LYS 1882 0.0008

LYS 1882 LEU 1883 0.0018

LEU 1883 LEU 1884 0.0006

LEU 1884 GLN 1885 -0.0216

GLN 1885 MET 1886 0.0013

MET 1886 GLY 1887 0.0003

GLY 1887 ILE 1888 0.0006

ILE 1888 LYS 1889 0.0020

LYS 1889 THR 1890 0.0003

THR 1890 PRO 1891 0.0018

PRO 1891 GLY 1892 0.0018

GLY 1892 LEU 1893 0.0011

LEU 1893 ILE 1894 0.0008

ILE 1894 ASP 1895 0.0017

ASP 1895 THR 1896 0.0021

THR 1896 LEU 1897 0.0011

LEU 1897 GLN 1898 0.0011

GLN 1898 PHE 1899 0.0008

PHE 1899 SER 1900 0.0021

SER 1900 LYS 1901 0.0214

LYS 1901 THR 1902 0.0017

THR 1902 ASP 1903 0.0004

ASP 1903 ALA 1904 0.0014

ALA 1904 THR 1905 0.0017

THR 1905 ASP 1906 0.0005

ASP 1906 ASN 1907 0.0018

ASN 1907 LEU 1908 0.0011

LEU 1908 PRO 1909 0.0017

PRO 1909 ASN 1910 0.0016

ASN 1910 ASP 1911 0.0006

ASP 1911 TYR 1912 0.0018

TYR 1912 ILE 1913 0.0017

ILE 1913 GLU 1914 0.0017

GLU 1914 ILE 1915 0.0012

ILE 1915 GLU 1916 0.0018

GLU 1916 PRO 1917 0.0038

PRO 1917 LYS 1918 0.0008

LYS 1918 ALA 1919 0.0001

ALA 1919 PHE 1920 0.0001

PHE 1920 GLY 1921 0.0002

GLY 1921 LEU 1922 0.0003

LEU 1922 ASN 1923 0.0002

ASN 1923 PHE 1924 0.0002

PHE 1924 ARG 1925 0.0010

ARG 1925 ASP 1926 0.0003

ASP 1926 VAL 1927 0.0005

VAL 1927 MET 1928 0.0003

MET 1928 VAL 1929 0.0006

VAL 1929 ALA 1930 0.0007

ALA 1930 MET 1931 0.0001

MET 1931 GLY 1932 0.0007

GLY 1932 GLN 1933 0.0439

GLN 1933 LEU 1934 0.0008

LEU 1934 GLU 1935 0.0004

GLU 1935 GLU 1936 0.0002

GLU 1936 SER 1937 0.0002

SER 1937 ILE 1938 0.0006

ILE 1938 MET 1939 0.0005

MET 1939 GLY 1940 0.0003

GLY 1940 PHE 1941 0.0008

PHE 1941 GLU 1942 0.0002

GLU 1942 CYS 1943 0.0001

CYS 1943 ALA 1944 0.0003

ALA 1944 GLY 1945 0.0001

GLY 1945 VAL 1946 0.0005

VAL 1946 VAL 1947 0.0006

VAL 1947 ARG 1948 0.0007

ARG 1948 ARG 1949 -0.0112

ARG 1949 VAL 1950 0.0014

VAL 1950 GLY 1951 0.0013

GLY 1951 PRO 1952 0.0010

PRO 1952 SER 1953 0.0005

SER 1953 SER 1954 0.0012

SER 1954 ALA 1955 0.0004

ALA 1955 GLY 1956 0.0014

GLY 1956 HIS 1957 0.0005

HIS 1957 ASN 1958 0.0012

ASN 1958 ILE 1959 0.0014

ILE 1959 LYS 1960 0.0004

LYS 1960 VAL 1961 0.0013

VAL 1961 GLY 1962 0.0014

GLY 1962 ASP 1963 0.0006

ASP 1963 ARG 1964 0.0007

ARG 1964 VAL 1965 0.0017

VAL 1965 CYS 1966 -0.0001

CYS 1966 ALA 1967 0.0010

ALA 1967 LEU 1968 0.0003

LEU 1968 LEU 1969 0.0013

LEU 1969 GLY 1970 0.0010

GLY 1970 GLY 1971 0.0013

GLY 1971 GLN 1972 0.0006

GLN 1972 TRP 1973 0.0013

TRP 1973 THR 1974 0.0000

THR 1974 ASN 1975 0.0003

ASN 1975 THR 1976 0.0012

THR 1976 VAL 1977 0.0009

VAL 1977 ARG 1978 0.0013

ARG 1978 VAL 1979 0.0008

VAL 1979 HIS 1980 0.0013

HIS 1980 TRP 1981 -0.0016

TRP 1981 HIS 1982 0.0002

HIS 1982 SER 1983 0.0013

SER 1983 VAL 1984 0.0003

VAL 1984 ALA 1985 0.0012

ALA 1985 PRO 1986 0.0005

PRO 1986 ILE 1987 0.0014

ILE 1987 PRO 1988 0.0010

PRO 1988 GLN 1989 0.0003

GLN 1989 ALA 1990 0.0010

ALA 1990 MET 1991 0.0006

MET 1991 ASP 1992 0.0014

ASP 1992 TRP 1993 0.0011

TRP 1993 GLU 1994 0.0003

GLU 1994 THR 1995 0.0009

THR 1995 ALA 1996 0.0013

ALA 1996 ALA 1997 0.0035

ALA 1997 SER 1998 0.0003

SER 1998 ILE 1999 0.0002

ILE 1999 PRO 2000 0.0005

PRO 2000 ILE 2001 0.0000

ILE 2001 VAL 2002 0.0004

VAL 2002 PHE 2003 0.0005

PHE 2003 VAL 2004 0.0005

VAL 2004 THR 2005 0.0002

THR 2005 ALA 2006 0.0003

ALA 2006 TYR 2007 0.0005

TYR 2007 ILE 2008 0.0003

ILE 2008 SER 2009 0.0001

SER 2009 LEU 2010 0.0004

LEU 2010 VAL 2011 0.0004

VAL 2011 LYS 2012 0.0004

LYS 2012 ILE 2013 -0.0077

ILE 2013 ALA 2014 0.0003

ALA 2014 ARG 2015 0.0001

ARG 2015 MET 2016 0.0002

MET 2016 GLN 2017 0.0001

GLN 2017 ALA 2018 0.0003

ALA 2018 GLY 2019 0.0002

GLY 2019 GLU 2020 0.0004

GLU 2020 THR 2021 0.0002

THR 2021 VAL 2022 0.0002

VAL 2022 LEU 2023 0.0003

LEU 2023 ILE 2024 0.0002

ILE 2024 HIS 2025 0.0003

HIS 2025 ALA 2026 0.0001

ALA 2026 ALA 2027 0.0002

ALA 2027 SER 2028 -0.0001

SER 2028 GLY 2029 0.0036

GLY 2029 GLY 2030 0.0004

GLY 2030 VAL 2031 0.0002

VAL 2031 GLY 2032 0.0003

GLY 2032 GLN 2033 0.0002

GLN 2033 ALA 2034 0.0001

ALA 2034 ALA 2035 0.0000

ALA 2035 ILE 2036 0.0003

ILE 2036 ILE 2037 0.0001

ILE 2037 LEU 2038 0.0003

LEU 2038 ALA 2039 0.0001

ALA 2039 LYS 2040 0.0003

LYS 2040 HIS 2041 0.0001

HIS 2041 VAL 2042 0.0000

VAL 2042 GLY 2043 0.0004

GLY 2043 ALA 2044 0.0002

ALA 2044 GLU 2045 0.0089

GLU 2045 ILE 2046 0.0002

ILE 2046 PHE 2047 0.0001

PHE 2047 ALA 2048 0.0003

ALA 2048 THR 2049 0.0004

THR 2049 VAL 2050 0.0002

VAL 2050 GLY 2051 0.0002

GLY 2051 THR 2052 0.0004

THR 2052 ASP 2053 0.0002

ASP 2053 GLU 2054 0.0002

GLU 2054 LYS 2055 0.0003

LYS 2055 ARG 2056 0.0001

ARG 2056 ASP 2057 0.0001

ASP 2057 LEU 2058 0.0001

LEU 2058 LEU 2059 0.0001

LEU 2059 ILE 2060 0.0005

ILE 2060 LYS 2061 -0.0037

LYS 2061 GLU 2062 0.0002

GLU 2062 TYR 2063 0.0001

TYR 2063 LYS 2064 0.0003

LYS 2064 ILE 2065 0.0001

ILE 2065 PRO 2066 0.0002

PRO 2066 ASP 2067 0.0002

ASP 2067 ASP 2068 0.0001

ASP 2068 HIS 2069 0.0002

HIS 2069 ILE 2070 0.0004

ILE 2070 PHE 2071 0.0002

PHE 2071 SER 2072 0.0003

SER 2072 SER 2073 0.0003

SER 2073 ARG 2074 0.0001

ARG 2074 ASN 2075 0.0002

ASN 2075 ALA 2076 0.0001

ALA 2076 LEU 2077 0.0042

LEU 2077 PHE 2078 0.0001

PHE 2078 ALA 2079 0.0001

ALA 2079 LYS 2080 0.0004

LYS 2080 SER 2081 0.0001

SER 2081 ILE 2082 0.0004

ILE 2082 ARG 2083 0.0001

ARG 2083 GLN 2084 0.0002

GLN 2084 ARG 2085 0.0000

ARG 2085 THR 2086 0.0003

THR 2086 ASN 2087 0.0004

ASN 2087 GLY 2088 0.0002

GLY 2088 LYS 2089 0.0004

LYS 2089 GLY 2090 0.0003

GLY 2090 VAL 2091 0.0001

VAL 2091 ASP 2092 0.0004

ASP 2092 VAL 2093 -0.0032

VAL 2093 VAL 2094 0.0003

VAL 2094 LEU 2095 0.0002

LEU 2095 ASN 2096 0.0002

ASN 2096 CYS 2097 0.0002

CYS 2097 LEU 2098 0.0003

LEU 2098 ALA 2099 -0.0000

ALA 2099 GLY 2100 0.0000

GLY 2100 GLY 2101 0.0004

GLY 2101 LEU 2102 -0.0000

LEU 2102 LEU 2103 0.0004

LEU 2103 GLN 2104 -0.0001

GLN 2104 GLU 2105 0.0001

GLU 2105 SER 2106 0.0001

SER 2106 PHE 2107 0.0003

PHE 2107 ASP 2108 0.0003

ASP 2108 CYS 2109 -0.0047

CYS 2109 LEU 2110 0.0003

LEU 2110 ALA 2111 0.0001

ALA 2111 ASP 2112 0.0002

ASP 2112 PHE 2113 0.0002

PHE 2113 GLY 2114 0.0002

GLY 2114 ARG 2115 0.0001

ARG 2115 PHE 2116 0.0002

PHE 2116 ILE 2117 0.0001

ILE 2117 GLU 2118 0.0002

GLU 2118 ILE 2119 0.0003

ILE 2119 GLY 2120 0.0001

GLY 2120 LYS 2121 0.0002

LYS 2121 ARG 2122 0.0002

ARG 2122 ASP 2123 0.0001

ASP 2123 ILE 2124 0.0001

ILE 2124 GLU 2125 -0.0184

GLU 2125 LEU 2126 0.0002

LEU 2126 ASN 2127 0.0005

ASN 2127 HIS 2128 0.0003

HIS 2128 CYS 2129 0.0003

CYS 2129 LEU 2130 0.0001

LEU 2130 ASN 2131 0.0004

ASN 2131 MET 2132 0.0003

MET 2132 GLY 2133 0.0002

GLY 2133 MET 2134 0.0001

MET 2134 PHE 2135 0.0004

PHE 2135 ALA 2136 0.0004

ALA 2136 ARG 2137 0.0003

ARG 2137 SER 2138 0.0003

SER 2138 ALA 2139 0.0003

ALA 2139 THR 2140 0.0003

THR 2140 PHE 2141 0.0047

PHE 2141 THR 2142 0.0004

THR 2142 ALA 2143 0.0005

ALA 2143 VAL 2144 0.0004

VAL 2144 ASP 2145 0.0005

ASP 2145 LEU 2146 0.0002

LEU 2146 ILE 2147 0.0009

ILE 2147 ALA 2148 0.0002

ALA 2148 ILE 2149 0.0004

ILE 2149 GLY 2150 0.0004

GLY 2150 ARG 2151 0.0003

ARG 2151 ASP 2152 0.0007

ASP 2152 ARG 2153 0.0005

ARG 2153 SER 2154 -0.0000

SER 2154 TYR 2155 0.0007

TYR 2155 MET 2156 0.0009

MET 2156 PHE 2157 0.0003

PHE 2157 ALA 2158 0.0003

ALA 2158 GLU 2159 0.0008

GLU 2159 ALA 2160 0.0007

ALA 2160 LEU 2161 0.0005

LEU 2161 PRO 2162 0.0003

PRO 2162 LYS 2163 0.0005

LYS 2163 ILE 2164 0.0010

ILE 2164 MET 2165 -0.0001

MET 2165 THR 2166 0.0007

THR 2166 LEU 2167 0.0006

LEU 2167 LEU 2168 0.0006

LEU 2168 GLN 2169 0.0000

GLN 2169 GLU 2170 0.0007

GLU 2170 LYS 2171 0.0007

LYS 2171 ALA 2172 -0.0000

ALA 2172 ILE 2173 0.0082

ILE 2173 ARG 2174 0.0009

ARG 2174 PRO 2175 0.0011

PRO 2175 VAL 2176 0.0001

VAL 2176 THR 2177 0.0009

THR 2177 PRO 2178 0.0009

PRO 2178 ILE 2179 0.0004

ILE 2179 SER 2180 0.0008

SER 2180 ILE 2181 0.0003

ILE 2181 TYR 2182 0.0008

TYR 2182 LYS 2183 0.0003

LYS 2183 ILE 2184 0.0007

ILE 2184 GLY 2185 0.0010

GLY 2185 ASP 2186 0.0003

ASP 2186 ILE 2187 0.0007

ILE 2187 GLU 2188 0.0003

GLU 2188 THR 2189 0.0084

THR 2189 ALA 2190 0.0010

ALA 2190 PHE 2191 0.0007

PHE 2191 ARG 2192 0.0006

ARG 2192 LEU 2193 0.0008

LEU 2193 MET 2194 0.0009

MET 2194 GLN 2195 0.0004

GLN 2195 ALA 2196 0.0008

ALA 2196 GLY 2197 0.0009

GLY 2197 LYS 2198 0.0008

LYS 2198 HIS 2199 0.0002

HIS 2199 MET 2200 0.0011

MET 2200 GLY 2201 0.0004

GLY 2201 LYS 2202 0.0008

LYS 2202 ILE 2203 0.0009

ILE 2203 VAL 2204 -0.0001

VAL 2204 ILE 2205 0.0471

ILE 2205 THR 2206 0.0013

THR 2206 ALA 2207 0.0042

ALA 2207 PRO 2208 0.0035

PRO 2208 GLU 2209 0.0034

GLU 2209 ASP 2210 0.0033

ASP 2210 ALA 2211 0.0016

ALA 2211 MET 2212 0.0035

MET 2212 VAL 2213 0.0031

VAL 2213 PRO 2214 0.0030

PRO 2214 VAL 2215 0.0043

VAL 2215 ILE 2216 0.0044

ILE 2216 THR 2217 0.0032

THR 2217 ARG 2218 0.0050

ARG 2218 PRO 2219 0.0050

PRO 2219 PRO 2220 0.0024

PRO 2220 LYS 2221 0.1159

LYS 2221 LEU 2222 0.0304

LEU 2222 GLN 2223 0.0222

GLN 2223 LEU 2224 0.0272

LEU 2224 ARG 2225 0.0295

ARG 2225 PRO 2226 0.0023

PRO 2226 ASP 2227 0.0389

ASP 2227 ALA 2228 0.0342

ALA 2228 SER 2229 0.0388

SER 2229 TYR 2230 0.0252

TYR 2230 LEU 2231 0.0402

LEU 2231 ILE 2232 0.0392

ILE 2232 VAL 2233 0.0403

VAL 2233 GLY 2234 0.0381

GLY 2234 GLY 2235 0.0348

GLY 2235 LEU 2236 0.0252

LEU 2236 GLY 2237 0.0458

GLY 2237 GLY 2238 0.0334

GLY 2238 ILE 2239 0.0164

ILE 2239 GLY 2240 0.0263

GLY 2240 ARG 2241 0.0227

ARG 2241 SER 2242 0.0177

SER 2242 LEU 2243 0.0350

LEU 2243 CYS 2244 0.0062

CYS 2244 LYS 2245 0.0392

LYS 2245 ASN 2246 0.0065

ASN 2246 PHE 2247 0.0386

PHE 2247 VAL 2248 0.0102

VAL 2248 GLU 2249 0.0323

GLU 2249 ASN 2250 0.0182

ASN 2250 GLY 2251 0.0241

GLY 2251 ALA 2252 0.0351

ALA 2252 ARG 2253 0.0090

ARG 2253 SER 2254 0.0420

SER 2254 LEU 2255 0.0382

LEU 2255 VAL 2256 0.0420

VAL 2256 LEU 2257 0.0419

LEU 2257 LEU 2258 0.0411

LEU 2258 SER 2259 0.0406

SER 2259 ARG 2260 0.0400

ARG 2260 ASN 2261 0.0170

ASN 2261 ALA 2262 0.0367

ALA 2262 ASN 2263 0.0087

ASN 2263 VAL 2264 0.0396

VAL 2264 SER 2265 0.0356

SER 2265 GLN 2266 0.0359

GLN 2266 GLN 2267 0.0099

GLN 2267 SER 2268 0.0360

SER 2268 GLY 2269 0.0237

GLY 2269 GLU 2270 0.0371

GLU 2270 PHE 2271 0.0078

PHE 2271 LEU 2272 0.0345

LEU 2272 ASP 2273 0.0208

ASP 2273 GLU 2274 0.0191

GLU 2274 LEU 2275 0.0300

LEU 2275 ARG 2276 0.0135

ARG 2276 SER 2277 0.0377

SER 2277 THR 2278 0.0132

THR 2278 GLY 2279 0.0344

GLY 2279 CYS 2280 0.0253

CYS 2280 ILE 2281 0.0350

ILE 2281 VAL 2282 0.0381

VAL 2282 GLY 2283 0.0394

GLY 2283 VAL 2284 0.0397

VAL 2284 VAL 2285 -0.0004

VAL 2285 ASP 2286 0.0434

ASP 2286 CYS 2287 0.0150

CYS 2287 ASP 2288 0.0234

ASP 2288 ILE 2289 0.0182

ILE 2289 SER 2290 0.0358

SER 2290 SER 2291 0.0212

SER 2291 LYS 2292 0.0418

LYS 2292 THR 2293 0.0037

THR 2293 GLN 2294 0.0391

GLN 2294 VAL 2295 0.0242

VAL 2295 GLU 2296 0.0412

GLU 2296 ALA 2297 0.0020

ALA 2297 THR 2298 0.0422

THR 2298 MET 2299 0.0316

MET 2299 LEU 2300 0.0214

LEU 2300 ARG 2301 0.0193

ARG 2301 LEU 2302 0.0303

LEU 2302 LYS 2303 0.0411

LYS 2303 LYS 2304 0.0007

LYS 2304 ASP 2305 0.0394

ASP 2305 MET 2306 0.0184

MET 2306 LEU 2307 0.0271

LEU 2307 PRO 2308 0.0128

PRO 2308 ILE 2309 0.0266

ILE 2309 ARG 2310 0.0138

ARG 2310 GLY 2311 0.0353

GLY 2311 ILE 2312 0.0424

ILE 2312 VAL 2313 0.0395

VAL 2313 HIS 2314 0.0422

HIS 2314 ALA 2315 0.0420

ALA 2315 GLY 2316 0.0367

GLY 2316 MET 2317 0.0344

MET 2317 VAL 2318 0.0525

VAL 2318 LEU 2319 0.0323

LEU 2319 GLN 2320 0.0516

GLN 2320 ASP 2321 0.0188

ASP 2321 SER 2322 0.0396

SER 2322 VAL 2323 0.0030

VAL 2323 PHE 2324 0.0508

PHE 2324 GLU 2325 0.0509

GLU 2325 ARG 2326 0.0073

ARG 2326 MET 2327 0.0417

MET 2327 SER 2328 0.0307

SER 2328 LEU 2329 0.0523

LEU 2329 ASP 2330 0.0091

ASP 2330 ASP 2331 0.0459

ASP 2331 TYR 2332 0.0300

TYR 2332 ASN 2333 0.0444

ASN 2333 THR 2334 0.0290

THR 2334 ALA 2335 0.0278

ALA 2335 ILE 2336 0.0392

ILE 2336 ARG 2337 0.0149

ARG 2337 PRO 2338 0.0442

PRO 2338 LYS 2339 0.0083

LYS 2339 VAL 2340 0.0446

VAL 2340 GLN 2341 0.0181

GLN 2341 GLY 2342 0.0338

GLY 2342 SER 2343 0.0269

SER 2343 TRP 2344 0.0473

TRP 2344 ASN 2345 0.0015

ASN 2345 LEU 2346 0.0479

LEU 2346 HIS 2347 0.0193

HIS 2347 SER 2348 0.0398

SER 2348 GLY 2349 0.0058

GLY 2349 LEU 2350 0.0411

LEU 2350 SER 2351 0.0278

SER 2351 ASP 2352 0.0235

ASP 2352 CYS 2353 0.0434

CYS 2353 ASP 2354 0.0312

ASP 2354 LEU 2355 0.0415

LEU 2355 ASP 2356 0.0380

ASP 2356 PHE 2357 0.0387

PHE 2357 PHE 2358 0.0431

PHE 2358 ILE 2359 0.0411

ILE 2359 MET 2360 0.0425

MET 2360 LEU 2361 0.0436

LEU 2361 SER 2362 0.0211

SER 2362 SER 2363 0.0362

SER 2363 LEU 2364 0.0106

LEU 2364 ALA 2365 0.0350

ALA 2365 GLY 2366 0.0473

GLY 2366 VAL 2367 0.0161

VAL 2367 SER 2368 0.0441

SER 2368 GLY 2369 0.0448

GLY 2369 SER 2370 0.0337

SER 2370 ALA 2371 0.0483

ALA 2371 SER 2372 0.0184

SER 2372 GLN 2373 0.0438

GLN 2373 ALA 2374 0.0381

ALA 2374 ASN 2375 0.0138

ASN 2375 TYR 2376 0.0459

TYR 2376 THR 2377 0.0064

THR 2377 ALA 2378 0.0489

ALA 2378 GLY 2379 0.0130

GLY 2379 GLY 2380 0.0420

GLY 2380 ALA 2381 0.0167

ALA 2381 TYR 2382 0.0302

TYR 2382 GLN 2383 0.0344

GLN 2383 ASP 2384 0.0115

ASP 2384 ALA 2385 0.0415

ALA 2385 LEU 2386 0.0098

LEU 2386 ALA 2387 0.0457

ALA 2387 LYS 2388 0.0098

LYS 2388 TYR 2389 0.0397

TYR 2389 ARG 2390 0.0186

ARG 2390 ARG 2391 0.0302

ARG 2391 ALA 2392 0.0284

ALA 2392 GLN 2393 0.0171

GLN 2393 GLY 2394 0.0441

GLY 2394 LEU 2395 0.0181

LEU 2395 SER 2396 0.0439

SER 2396 ALA 2397 0.0298

ALA 2397 VAL 2398 0.0383

VAL 2398 SER 2399 0.0407

SER 2399 ILE 2400 0.0403

ILE 2400 ASP 2401 0.0351

ASP 2401 LEU 2402 0.0233

LEU 2402 GLY 2403 0.0385

GLY 2403 MET 2404 0.0239

MET 2404 VAL 2405 0.0168

VAL 2405 GLN 2406 0.0373

GLN 2406 SER 2407 0.0076

SER 2407 VAL 2408 0.0347

VAL 2408 GLY 2409 0.0409

GLY 2409 TYR 2410 0.0377

TYR 2410 VAL 2411 0.0254

VAL 2411 ALA 2412 0.0229

ALA 2412 GLU 2413 -0.0029

GLU 2413 THR 2414 0.0340

THR 2414 LYS 2415 0.0427

LYS 2415 GLY 2416 0.0045

GLY 2416 VAL 2417 0.0382

VAL 2417 ALA 2418 0.0398

ALA 2418 GLU 2419 0.0341

GLU 2419 ARG 2420 0.0383

ARG 2420 LEU 2421 0.0413

LEU 2421 VAL 2422 0.0379

VAL 2422 ARG 2423 0.0339

ARG 2423 MET 2424 0.0412

MET 2424 GLY 2425 0.0389

GLY 2425 TYR 2426 0.0205

TYR 2426 SER 2427 0.0429

SER 2427 PRO 2428 0.0040

PRO 2428 ILE 2429 0.0514

ILE 2429 SER 2430 0.0126

SER 2430 GLU 2431 0.0150

GLU 2431 MET 2432 0.0284

MET 2432 GLU 2433 0.0047

GLU 2433 VAL 2434 0.0273

VAL 2434 LEU 2435 0.0233

LEU 2435 LYS 2436 0.0120

LYS 2436 ILE 2437 0.0223

ILE 2437 VAL 2438 0.0161

VAL 2438 GLU 2439 0.0317

GLU 2439 HIS 2440 0.0004

HIS 2440 ALA 2441 0.0319

ALA 2441 ILE 2442 0.0185

ILE 2442 THR 2443 0.0259

THR 2443 ASN 2444 0.0028

ASN 2444 PRO 2445 0.1645

PRO 2445 PRO 2446 0.0042

PRO 2446 PRO 2447 0.0368

PRO 2447 GLU 2448 0.0278

GLU 2448 ALA 2449 0.0399

ALA 2449 SER 2450 0.0205

SER 2450 SER 2451 0.0338

SER 2451 ALA 2452 0.0092

ALA 2452 GLN 2453 0.0413

GLN 2453 ILE 2454 0.0416

ILE 2454 ILE 2455 0.0363

ILE 2455 THR 2456 0.0361

THR 2456 GLY 2457 0.0421

GLY 2457 ILE 2458 0.0020

ILE 2458 SER 2459 0.0368

SER 2459 THR 2460 0.0172

THR 2460 LYS 2461 0.0533

LYS 2461 PRO 2462 0.0202

PRO 2462 GLY 2463 0.0417

GLY 2463 ARG 2464 0.0420

ARG 2464 HIS 2465 0.0359

HIS 2465 TRP 2466 0.0136

TRP 2466 THR 2467 0.0329

THR 2467 GLU 2468 0.0219

GLU 2468 SER 2469 0.0362

SER 2469 SER 2470 0.0337

SER 2470 TRP 2471 0.0386

TRP 2471 LEU 2472 0.0392

LEU 2472 GLN 2473 0.0072

GLN 2473 ASP 2474 0.0433

ASP 2474 ALA 2475 0.0287

ALA 2475 ARG 2476 0.0163

ARG 2476 PHE 2477 0.0503

PHE 2477 ALA 2478 0.0094

ALA 2478 THR 2479 0.0458

THR 2479 LEU 2480 0.0187

LEU 2480 ARG 2481 0.0362

ARG 2481 GLU 2482 0.0293

GLU 2482 ARG 2483 0.0212

ARG 2483 ALA 2484 0.0430

ALA 2484 ARG 2485 0.0104

ARG 2485 ASP 2486 0.0483

ASP 2486 VAL 2487 0.0097

VAL 2487 LYS 2488 0.0420

LYS 2488 GLU 2489 0.0145

GLU 2489 LEU 2490 0.0380

LEU 2490 SER 2491 0.0380

SER 2491 ASN 2492 0.0142

ASN 2492 SER 2493 0.0744

SER 2493 GLN 2494 0.0442

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** sdgklnrdh ***

CA strain for 22101813491974862

--- normal mode 9 ---

Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *