Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *

CA strain for 22101813491974862

--- normal mode 8 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
ASN 989 LYS 990 0.0024

LYS 990 ALA 991 0.0021

ALA 991 HIS 992 0.0010

HIS 992 ARG 993 0.0024

ARG 993 GLN 994 0.0024

GLN 994 ARG 995 0.0020

ARG 995 VAL 996 0.0019

VAL 996 HIS 997 0.0016

HIS 997 PRO 998 0.0014

PRO 998 PRO 999 0.0026

PRO 999 HIS 1000 0.0021

HIS 1000 ASP 1001 0.0011

ASP 1001 LEU 1002 0.0016

LEU 1002 LEU 1003 0.0003

LEU 1003 GLY 1004 0.0024

GLY 1004 SER 1005 0.0089

SER 1005 LEU 1006 0.0006

LEU 1006 ILE 1007 0.0009

ILE 1007 VAL 1008 0.0013

VAL 1008 GLY 1009 0.0000

GLY 1009 ARG 1010 0.0020

ARG 1010 ASP 1011 0.0018

ASP 1011 LEU 1012 0.0011

LEU 1012 ARG 1013 0.0017

ARG 1013 GLU 1014 0.0015

GLU 1014 PRO 1015 0.0013

PRO 1015 THR 1016 0.0013

THR 1016 TRP 1017 0.0007

TRP 1017 ARG 1018 0.0020

ARG 1018 HIS 1019 0.0002

HIS 1019 PHE 1020 0.0018

PHE 1020 ILE 1021 -0.0421

ILE 1021 ARG 1022 0.0005

ARG 1022 VAL 1023 0.0011

VAL 1023 GLN 1024 0.0020

GLN 1024 ASP 1025 0.0017

ASP 1025 ILE 1026 0.0029

ILE 1026 PRO 1027 0.0010

PRO 1027 TRP 1028 0.0029

TRP 1028 ILE 1029 0.0019

ILE 1029 ARG 1030 0.0010

ARG 1030 ASP 1031 0.0031

ASP 1031 HIS 1032 0.0007

HIS 1032 VAL 1033 0.0030

VAL 1033 VAL 1034 0.0019

VAL 1034 GLN 1035 0.0030

GLN 1035 SER 1036 0.0012

SER 1036 ALA 1037 -0.0380

ALA 1037 LEU 1038 0.0022

LEU 1038 VAL 1039 0.0012

VAL 1039 TYR 1040 0.0023

TYR 1040 PRO 1041 0.0023

PRO 1041 GLY 1042 0.0004

GLY 1042 ALA 1043 0.0022

ALA 1043 GLY 1044 0.0024

GLY 1044 PHE 1045 0.0002

PHE 1045 ILE 1046 0.0022

ILE 1046 CYS 1047 0.0012

CYS 1047 MET 1048 0.0016

MET 1048 ALA 1049 0.0009

ALA 1049 MET 1050 0.0019

MET 1050 GLU 1051 0.0021

GLU 1051 ALA 1052 0.0002

ALA 1052 MET 1053 -0.0203

MET 1053 VAL 1054 0.0014

VAL 1054 GLN 1055 0.0023

GLN 1055 LEU 1056 0.0006

LEU 1056 HIS 1057 0.0025

HIS 1057 GLU 1058 0.0024

GLU 1058 LEU 1059 0.0006

LEU 1059 ARG 1060 0.0021

ARG 1060 ASP 1061 0.0019

ASP 1061 SER 1062 0.0028

SER 1062 GLN 1063 0.0029

GLN 1063 SER 1064 0.0004

SER 1064 ARG 1065 0.0028

ARG 1065 LYS 1066 0.0005

LYS 1066 VAL 1067 0.0030

VAL 1067 ALA 1068 0.0025

ALA 1068 GLY 1069 -0.0133

GLY 1069 TYR 1070 0.0021

TYR 1070 ARG 1071 0.0016

ARG 1071 LEU 1072 0.0021

LEU 1072 ALA 1073 0.0015

ALA 1073 GLU 1074 0.0022

GLU 1074 VAL 1075 0.0011

VAL 1075 ASP 1076 0.0025

ASP 1076 ILE 1077 0.0009

ILE 1077 LEU 1078 0.0019

LEU 1078 ARG 1079 0.0010

ARG 1079 ALA 1080 0.0003

ALA 1080 MET 1081 0.0022

MET 1081 LEU 1082 0.0011

LEU 1082 ILE 1083 0.0016

ILE 1083 PRO 1084 0.0021

PRO 1084 ASP 1085 0.0361

ASP 1085 THR 1086 0.0016

THR 1086 SER 1087 0.0021

SER 1087 GLU 1088 0.0001

GLU 1088 GLY 1089 0.0023

GLY 1089 LEU 1090 0.0007

LEU 1090 GLU 1091 0.0005

GLU 1091 ALA 1092 0.0020

ALA 1092 HIS 1093 0.0008

HIS 1093 ILE 1094 0.0020

ILE 1094 SER 1095 0.0002

SER 1095 LEU 1096 0.0017

LEU 1096 ARG 1097 0.0003

ARG 1097 PRO 1098 0.0019

PRO 1098 CYS 1099 0.0020

CYS 1099 SER 1100 0.0001

SER 1100 THR 1101 -0.0039

THR 1101 LYS 1102 0.0021

LYS 1102 LEU 1103 0.0007

LEU 1103 LEU 1104 0.0020

LEU 1104 LEU 1105 0.0011

LEU 1105 THR 1106 0.0022

THR 1106 ASN 1107 0.0014

ASN 1107 GLU 1108 0.0022

GLU 1108 TRP 1109 0.0012

TRP 1109 TYR 1110 0.0022

TYR 1110 ASP 1111 0.0020

ASP 1111 PHE 1112 0.0006

PHE 1112 CYS 1113 0.0020

CYS 1113 VAL 1114 0.0005

VAL 1114 SER 1115 0.0021

SER 1115 SER 1116 0.0013

SER 1116 VAL 1117 -0.0051

VAL 1117 GLY 1118 0.0016

GLY 1118 ASP 1119 0.0021

ASP 1119 ASP 1120 0.0005

ASP 1120 ASP 1121 0.0014

ASP 1121 LYS 1122 0.0023

LYS 1122 PHE 1123 0.0023

PHE 1123 VAL 1124 0.0013

VAL 1124 ASP 1125 0.0020

ASP 1125 HIS 1126 0.0007

HIS 1126 CYS 1127 0.0018

CYS 1127 ARG 1128 0.0005

ARG 1128 GLY 1129 0.0021

GLY 1129 ARG 1130 0.0015

ARG 1130 ILE 1131 0.0021

ILE 1131 THR 1132 0.0018

THR 1132 ILE 1133 -0.0007

ILE 1133 GLU 1134 0.0028

GLU 1134 PHE 1135 0.0027

PHE 1135 ASP 1136 0.0022

ASP 1136 THR 1137 0.0014

THR 1137 SER 1138 0.0025

SER 1138 GLY 1139 0.0025

GLY 1139 SER 1140 0.0027

SER 1140 ALA 1141 0.0014

ALA 1141 ASP 1142 0.0022

ASP 1142 THR 1143 0.0018

THR 1143 PRO 1144 0.0008

PRO 1144 ARG 1145 0.0029

ARG 1145 THR 1146 0.0027

THR 1146 SER 1147 -0.0001

SER 1147 LEU 1148 0.0027

LEU 1148 ARG 1149 0.0796

ARG 1149 GLU 1150 0.0018

GLU 1150 ARG 1151 0.0013

ARG 1151 SER 1152 0.0023

SER 1152 ARG 1153 0.0030

ARG 1153 SER 1154 0.0013

SER 1154 THR 1155 0.0029

THR 1155 GLY 1156 0.0030

GLY 1156 LEU 1157 0.0022

LEU 1157 MET 1158 0.0031

MET 1158 ARG 1159 0.0031

ARG 1159 SER 1160 0.0018

SER 1160 VAL 1161 0.0024

VAL 1161 ASP 1162 0.0024

ASP 1162 PRO 1163 0.0029

PRO 1163 SER 1164 0.0031

SER 1164 ASN 1165 0.0323

ASN 1165 LEU 1166 0.0018

LEU 1166 TYR 1167 0.0035

TYR 1167 SER 1168 0.0040

SER 1168 PHE 1169 0.0004

PHE 1169 LEU 1170 0.0039

LEU 1170 ARG 1171 0.0023

ARG 1171 ALA 1172 0.0042

ALA 1172 GLN 1173 0.0006

GLN 1173 GLY 1174 0.0042

GLY 1174 ILE 1175 0.0047

ILE 1175 TYR 1176 0.0002

TYR 1176 HIS 1177 0.0042

HIS 1177 GLY 1178 0.0003

GLY 1178 PRO 1179 0.0028

PRO 1179 ILE 1180 0.0038

ILE 1180 PHE 1181 0.0001

PHE 1181 GLN 1182 0.0028

GLN 1182 ASN 1183 0.0033

ASN 1183 LEU 1184 0.0033

LEU 1184 LYS 1185 0.0017

LYS 1185 THR 1186 0.0028

THR 1186 ILE 1187 0.0010

ILE 1187 SER 1188 0.0031

SER 1188 SER 1189 0.0009

SER 1189 ARG 1190 0.0018

ARG 1190 LYS 1191 0.0008

LYS 1191 ASP 1192 0.0028

ASP 1192 HIS 1193 0.0016

HIS 1193 SER 1194 0.0007

SER 1194 GLU 1195 0.0016

GLU 1195 SER 1196 0.0025

SER 1196 SER 1197 -0.0162

SER 1197 PHE 1198 0.0034

PHE 1198 VAL 1199 0.0029

VAL 1199 VAL 1200 0.0028

VAL 1200 ALA 1201 0.0030

ALA 1201 ASN 1202 0.0026

ASN 1202 THR 1203 0.0020

THR 1203 ALA 1204 0.0032

ALA 1204 SER 1205 0.0005

SER 1205 VAL 1206 0.0031

VAL 1206 MET 1207 0.0024

MET 1207 PRO 1208 0.0029

PRO 1208 ASN 1209 0.0022

ASN 1209 GLY 1210 0.0031

GLY 1210 PHE 1211 0.0008

PHE 1211 GLN 1212 0.0011

GLN 1212 SER 1213 0.0078

SER 1213 PRO 1214 0.0028

PRO 1214 HIS 1215 0.0019

HIS 1215 VAL 1216 0.0021

VAL 1216 ILE 1217 0.0025

ILE 1217 HIS 1218 0.0021

HIS 1218 PRO 1219 0.0023

PRO 1219 THR 1220 0.0008

THR 1220 THR 1221 0.0028

THR 1221 LEU 1222 0.0001

LEU 1222 ASP 1223 0.0027

ASP 1223 SER 1224 0.0013

SER 1224 ILE 1225 0.0013

ILE 1225 PHE 1226 0.0021

PHE 1226 GLN 1227 0.0011

GLN 1227 GLY 1228 0.0029

GLY 1228 ALA 1229 -0.0111

ALA 1229 TYR 1230 0.0037

TYR 1230 THR 1231 0.0035

THR 1231 ALA 1232 0.0009

ALA 1232 LEU 1233 0.0037

LEU 1233 PRO 1234 0.0042

PRO 1234 GLY 1235 0.0003

GLY 1235 ALA 1236 0.0038

ALA 1236 GLY 1237 0.0035

GLY 1237 LEU 1238 0.0026

LEU 1238 ASP 1239 0.0018

ASP 1239 GLN 1240 0.0030

GLN 1240 ASN 1241 0.0037

ASN 1241 THR 1242 0.0040

THR 1242 ALA 1243 0.0032

ALA 1243 MET 1244 0.0030

MET 1244 ILE 1245 -0.0301

ILE 1245 PRO 1246 0.0018

PRO 1246 ARG 1247 0.0003

ARG 1247 SER 1248 0.0019

SER 1248 ILE 1249 0.0026

ILE 1249 GLN 1250 0.0009

GLN 1250 GLU 1251 0.0023

GLU 1251 LEU 1252 0.0005

LEU 1252 TYR 1253 0.0026

TYR 1253 LEU 1254 0.0008

LEU 1254 SER 1255 0.0024

SER 1255 SER 1256 0.0023

SER 1256 ALA 1257 0.0014

ALA 1257 LEU 1258 0.0022

LEU 1258 THR 1259 0.0005

THR 1259 SER 1260 0.0023

SER 1260 ASP 1261 0.0061

ASP 1261 VAL 1262 0.0032

VAL 1262 GLY 1263 0.0039

GLY 1263 GLN 1264 0.0022

GLN 1264 CYS 1265 0.0031

CYS 1265 LEU 1266 0.0000

LEU 1266 VAL 1267 0.0028

VAL 1267 SER 1268 0.0008

SER 1268 ASP 1269 0.0021

ASP 1269 THR 1270 0.0024

THR 1270 SER 1271 0.0012

SER 1271 LEU 1272 0.0030

LEU 1272 ILE 1273 0.0003

ILE 1273 ARG 1274 0.0037

ARG 1274 TYR 1275 0.0035

TYR 1275 ASP 1276 0.0033

ASP 1276 GLY 1277 -0.0088

GLY 1277 GLN 1278 0.0030

GLN 1278 SER 1279 0.0032

SER 1279 PHE 1280 0.0029

PHE 1280 THR 1281 0.0031

THR 1281 VAL 1282 0.0019

VAL 1282 ASN 1283 0.0032

ASN 1283 VAL 1284 0.0006

VAL 1284 ASP 1285 0.0026

ASP 1285 VAL 1286 0.0005

VAL 1286 SER 1287 0.0021

SER 1287 SER 1288 0.0006

SER 1288 LYS 1289 0.0017

LYS 1289 ALA 1290 0.0025

ALA 1290 ASP 1291 0.0008

ASP 1291 SER 1292 0.0032

SER 1292 GLU 1293 0.0167

GLU 1293 HIS 1294 0.0031

HIS 1294 THR 1295 0.0017

THR 1295 PRO 1296 0.0029

PRO 1296 VAL 1297 0.0027

VAL 1297 LEU 1298 0.0021

LEU 1298 GLU 1299 0.0010

GLU 1299 ILE 1300 0.0024

ILE 1300 LYS 1301 0.0006

LYS 1301 GLY 1302 0.0027

GLY 1302 LEU 1303 0.0014

LEU 1303 ARG 1304 0.0025

ARG 1304 ASN 1305 0.0019

ASN 1305 GLN 1306 0.0028

GLN 1306 SER 1307 0.0027

SER 1307 VAL 1308 0.0030

VAL 1308 GLY 1309 -0.1929

GLY 1309 GLN 1310 0.0079

GLN 1310 MET 1311 0.0002

MET 1311 ALA 1312 0.0090

ALA 1312 PRO 1313 0.0088

PRO 1313 GLN 1314 -0.0001

GLN 1314 PRO 1315 0.0085

PRO 1315 GLY 1316 0.0093

GLY 1316 ASP 1317 0.0043

ASP 1317 SER 1318 0.0045

SER 1318 SER 1319 0.0065

SER 1319 ASN 1320 0.0089

ASN 1320 ASN 1321 0.0037

ASN 1321 ASP 1322 0.0081

ASP 1322 LEU 1323 0.0078

LEU 1323 CYS 1324 0.0090

CYS 1324 PHE 1325 0.0041

PHE 1325 LYS 1326 0.0203

LYS 1326 LEU 1327 0.0242

LEU 1327 ASP 1328 0.0251

ASP 1328 TRP 1329 0.0255

TRP 1329 ALA 1330 0.0247

ALA 1330 PRO 1331 0.0249

PRO 1331 ASP 1332 0.0026

ASP 1332 ILE 1333 0.0242

ILE 1333 SER 1334 0.0144

SER 1334 SER 1335 0.0119

SER 1335 VAL 1336 0.0124

VAL 1336 LYS 1337 0.0221

LYS 1337 GLN 1338 0.0251

GLN 1338 GLU 1339 0.0026

GLU 1339 ARG 1340 0.0233

ARG 1340 LEU 1341 0.0349

LEU 1341 LYS 1342 0.0239

LYS 1342 GLU 1343 0.0055

GLU 1343 LYS 1344 0.0283

LYS 1344 PHE 1345 0.0211

PHE 1345 GLY 1346 0.0269

GLY 1346 PHE 1347 0.0204

PHE 1347 PRO 1348 0.0130

PRO 1348 LEU 1349 0.0288

LEU 1349 ASP 1350 0.0214

ASP 1350 PRO 1351 0.0206

PRO 1351 THR 1352 0.0285

THR 1352 GLU 1353 0.0004

GLU 1353 ALA 1354 0.0289

ALA 1354 ASP 1355 0.0224

ASP 1355 ILE 1356 0.0161

ILE 1356 ILE 1357 0.0059

ILE 1357 MET 1358 0.0244

MET 1358 GLY 1359 0.0296

GLY 1359 LEU 1360 0.0020

LEU 1360 ARG 1361 0.0281

ARG 1361 GLN 1362 0.0208

GLN 1362 ALA 1363 0.0257

ALA 1363 CYS 1364 0.0041

CYS 1364 ILE 1365 0.0292

ILE 1365 HIS 1366 0.0266

HIS 1366 PHE 1367 0.0097

PHE 1367 ILE 1368 0.0201

ILE 1368 HIS 1369 0.0231

HIS 1369 ARG 1370 0.0301

ARG 1370 SER 1371 0.0020

SER 1371 LEU 1372 0.0280

LEU 1372 GLN 1373 0.0210

GLN 1373 SER 1374 0.0250

SER 1374 LEU 1375 0.0040

LEU 1375 THR 1376 0.0223

THR 1376 ALA 1377 0.0117

ALA 1377 PRO 1378 0.0181

PRO 1378 ASP 1379 0.0232

ASP 1379 ARG 1380 0.0294

ARG 1380 ASP 1381 0.0012

ASP 1381 GLN 1382 0.0295

GLN 1382 LEU 1383 0.0243

LEU 1383 ASP 1384 0.0199

ASP 1384 TRP 1385 0.0290

TRP 1385 HIS 1386 0.0144

HIS 1386 GLN 1387 0.0180

GLN 1387 LYS 1388 0.0287

LYS 1388 ARG 1389 0.0303

ARG 1389 PHE 1390 0.0104

PHE 1390 TYR 1391 0.0292

TYR 1391 ASP 1392 0.0299

ASP 1392 TRP 1393 0.0187

TRP 1393 MET 1394 0.0183

MET 1394 VAL 1395 0.0300

VAL 1395 LEU 1396 0.0289

LEU 1396 GLN 1397 0.0121

GLN 1397 ILE 1398 0.0252

ILE 1398 GLN 1399 0.0295

GLN 1399 LEU 1400 0.0247

LEU 1400 ALA 1401 0.0134

ALA 1401 GLU 1402 0.0295

GLU 1402 GLU 1403 0.0300

GLU 1403 ASP 1404 0.0145

ASP 1404 ARG 1405 0.0179

ARG 1405 LEU 1406 0.0299

LEU 1406 ALA 1407 0.0014

ALA 1407 PRO 1408 0.0117

PRO 1408 ASN 1409 0.0295

ASN 1409 SER 1410 0.0100

SER 1410 SER 1411 0.0296

SER 1411 ALA 1412 0.0116

ALA 1412 TRP 1413 0.0221

TRP 1413 LEU 1414 0.0206

LEU 1414 GLN 1415 0.0107

GLN 1415 CYS 1416 0.0264

CYS 1416 SER 1417 0.0257

SER 1417 SER 1418 0.0232

SER 1418 SER 1419 0.0106

SER 1419 ASP 1420 0.0299

ASP 1420 GLU 1421 0.0006

GLU 1421 GLN 1422 0.0296

GLN 1422 LYS 1423 0.0130

LYS 1423 LEU 1424 0.0220

LEU 1424 LEU 1425 0.0115

LEU 1425 GLU 1426 0.0207

GLU 1426 ASN 1427 0.0244

ASN 1427 VAL 1428 0.0074

VAL 1428 ARG 1429 0.0251

ARG 1429 ALA 1430 0.0127

ALA 1430 SER 1431 0.0299

SER 1431 SER 1432 0.0059

SER 1432 VAL 1433 0.0051

VAL 1433 ASN 1434 0.0272

ASN 1434 GLY 1435 0.0200

GLY 1435 GLN 1436 0.0264

GLN 1436 MET 1437 0.0042

MET 1437 VAL 1438 0.0285

VAL 1438 VAL 1439 0.0232

VAL 1439 HIS 1440 0.0151

HIS 1440 VAL 1441 0.0129

VAL 1441 GLY 1442 0.0227

GLY 1442 LYS 1443 0.0281

LYS 1443 SER 1444 0.0020

SER 1444 MET 1445 0.0265

MET 1445 LEU 1446 0.0278

LEU 1446 ALA 1447 0.0237

ALA 1447 ILE 1448 0.0229

ILE 1448 LEU 1449 0.0274

LEU 1449 ARG 1450 0.0264

ARG 1450 HIS 1451 0.0220

HIS 1451 GLU 1452 0.0206

GLU 1452 ILE 1453 0.0208

ILE 1453 ALA 1454 0.0236

ALA 1454 PRO 1455 0.0184

PRO 1455 LEU 1456 0.0276

LEU 1456 GLU 1457 0.0292

GLU 1457 LEU 1458 0.0054

LEU 1458 MET 1459 0.0283

MET 1459 LEU 1460 0.0269

LEU 1460 GLN 1461 0.0192

GLN 1461 ASP 1462 0.0144

ASP 1462 LYS 1463 0.0244

LYS 1463 LEU 1464 0.0231

LEU 1464 LEU 1465 0.0150

LEU 1465 TYR 1466 0.0297

TYR 1466 ARG 1467 0.0005

ARG 1467 TYR 1468 0.0294

TYR 1468 TYR 1469 0.0196

TYR 1469 THR 1470 0.0149

THR 1470 ASP 1471 0.0064

ASP 1471 ALA 1472 0.0284

ALA 1472 ILE 1473 0.0191

ILE 1473 LYS 1474 0.0263

LYS 1474 TRP 1475 0.0155

TRP 1475 ASP 1476 0.0202

ASP 1476 ARG 1477 0.0273

ARG 1477 SER 1478 0.0024

SER 1478 TYR 1479 0.0269

TYR 1479 GLN 1480 0.0135

GLN 1480 GLN 1481 0.0249

GLN 1481 ILE 1482 0.0056

ILE 1482 ASP 1483 0.0249

ASP 1483 GLN 1484 0.0249

GLN 1484 LEU 1485 0.0085

LEU 1485 VAL 1486 0.0183

VAL 1486 LYS 1487 0.0170

LYS 1487 LEU 1488 0.0264

LEU 1488 HIS 1489 0.0008

HIS 1489 ALA 1490 0.0266

ALA 1490 HIS 1491 0.0194

HIS 1491 LYS 1492 0.0163

LYS 1492 CYS 1493 0.0084

CYS 1493 PRO 1494 0.0259

PRO 1494 THR 1495 0.0007

THR 1495 ALA 1496 0.0266

ALA 1496 LYS 1497 0.0135

LYS 1497 ILE 1498 0.0206

ILE 1498 ILE 1499 0.0241

ILE 1499 GLU 1500 0.0185

GLU 1500 ILE 1501 0.0252

ILE 1501 GLY 1502 0.0256

GLY 1502 ALA 1503 0.0160

ALA 1503 GLY 1504 0.0277

GLY 1504 THR 1505 0.0112

THR 1505 GLY 1506 0.0266

GLY 1506 GLY 1507 0.0082

GLY 1507 CYS 1508 0.0269

CYS 1508 THR 1509 0.0212

THR 1509 ARG 1510 0.0082

ARG 1510 ALA 1511 0.0214

ALA 1511 VAL 1512 0.0096

VAL 1512 LEU 1513 0.0273

LEU 1513 ASP 1514 0.0015

ASP 1514 ALA 1515 0.0277

ALA 1515 LEU 1516 0.0087

LEU 1516 SER 1517 0.0088

SER 1517 ASN 1518 0.0172

ASN 1518 GLN 1519 0.0218

GLN 1519 GLY 1520 0.0087

GLY 1520 ILE 1521 0.0134

ILE 1521 ALA 1522 0.0178

ALA 1522 ARG 1523 0.0267

ARG 1523 CYS 1524 0.0056

CYS 1524 ALA 1525 0.0030

ALA 1525 GLN 1526 0.0258

GLN 1526 TYR 1527 0.0220

TYR 1527 ASP 1528 0.0170

ASP 1528 PHE 1529 0.0210

PHE 1529 THR 1530 0.0198

THR 1530 ASP 1531 0.0269

ASP 1531 VAL 1532 0.0165

VAL 1532 SER 1533 0.0292

SER 1533 SER 1534 0.0276

SER 1534 GLY 1535 0.0155

GLY 1535 PHE 1536 0.0117

PHE 1536 PHE 1537 0.0226

PHE 1537 GLU 1538 0.0261

GLU 1538 ALA 1539 0.0020

ALA 1539 ALA 1540 0.0274

ALA 1540 GLN 1541 0.0227

GLN 1541 GLN 1542 0.0132

GLN 1542 LYS 1543 0.0143

LYS 1543 PHE 1544 0.0246

PHE 1544 ALA 1545 0.0243

ALA 1545 ALA 1546 0.0189

ALA 1546 PHE 1547 0.0169

PHE 1547 ASP 1548 0.0072

ASP 1548 ASP 1549 0.0151

ASP 1549 VAL 1550 0.0273

VAL 1550 ILE 1551 0.0271

ILE 1551 ARG 1552 0.0050

ARG 1552 PHE 1553 0.0274

PHE 1553 GLN 1554 0.0121

GLN 1554 LYS 1555 0.0263

LYS 1555 LEU 1556 0.0276

LEU 1556 ASP 1557 0.0265

ASP 1557 ILE 1558 0.0259

ILE 1558 GLU 1559 0.0200

GLU 1559 LYS 1560 0.0086

LYS 1560 ASP 1561 0.0219

ASP 1561 ILE 1562 0.0215

ILE 1562 GLU 1563 0.0116

GLU 1563 MET 1564 0.0229

MET 1564 GLN 1565 0.0106

GLN 1565 GLY 1566 0.0278

GLY 1566 PHE 1567 0.0146

PHE 1567 GLU 1568 0.0267

GLU 1568 CYS 1569 0.0274

CYS 1569 GLY 1570 0.0179

GLY 1570 SER 1571 0.0251

SER 1571 TYR 1572 0.0029

TYR 1572 ASP 1573 0.0105

ASP 1573 LEU 1574 0.0182

LEU 1574 VAL 1575 0.0267

VAL 1575 ILE 1576 0.0132

ILE 1576 ALA 1577 0.0279

ALA 1577 SER 1578 0.0106

SER 1578 GLN 1579 0.0279

GLN 1579 VAL 1580 0.0004

VAL 1580 LEU 1581 0.0150

LEU 1581 HIS 1582 0.0245

HIS 1582 ALA 1583 0.0195

ALA 1583 THR 1584 0.0082

THR 1584 GLY 1585 0.0188

GLY 1585 LYS 1586 0.0283

LYS 1586 MET 1587 0.0162

MET 1587 GLU 1588 0.0203

GLU 1588 HIS 1589 0.0138

HIS 1589 THR 1590 0.0168

THR 1590 MET 1591 0.0237

MET 1591 ALA 1592 0.0063

ALA 1592 ASN 1593 0.0276

ASN 1593 VAL 1594 0.0054

VAL 1594 ARG 1595 0.0275

ARG 1595 LYS 1596 0.0089

LYS 1596 LEU 1597 0.0224

LEU 1597 LEU 1598 0.0195

LEU 1598 LYS 1599 0.0269

LYS 1599 PRO 1600 0.0277

PRO 1600 GLY 1601 0.0006

GLY 1601 GLY 1602 0.0278

GLY 1602 LYS 1603 0.0109

LYS 1603 LEU 1604 0.0283

LEU 1604 LEU 1605 0.0082

LEU 1605 LEU 1606 0.0279

LEU 1606 VAL 1607 0.0147

VAL 1607 GLU 1608 0.0278

GLU 1608 THR 1609 0.0223

THR 1609 THR 1610 0.0278

THR 1610 ARG 1611 0.0179

ARG 1611 ASP 1612 0.0283

ASP 1612 GLU 1613 0.0225

GLU 1613 MET 1614 0.0296

MET 1614 ASP 1615 0.0291

ASP 1615 LEU 1616 0.0116

LEU 1616 GLN 1617 0.0203

GLN 1617 LEU 1618 0.0275

LEU 1618 VAL 1619 0.0285

VAL 1619 PHE 1620 0.0071

PHE 1620 GLY 1621 0.0268

GLY 1621 LEU 1622 0.0273

LEU 1622 LEU 1623 0.0161

LEU 1623 PRO 1624 0.0062

PRO 1624 GLY 1625 0.0296

GLY 1625 TRP 1626 0.0125

TRP 1626 TRP 1627 0.0202

TRP 1627 LEU 1628 0.0091

LEU 1628 SER 1629 0.0315

SER 1629 SER 1630 0.0166

SER 1630 GLU 1631 0.0212

GLU 1631 GLU 1632 0.0227

GLU 1632 GLU 1633 0.0081

GLU 1633 ARG 1634 0.0292

ARG 1634 GLN 1635 0.0279

GLN 1635 MET 1636 0.0023

MET 1636 SER 1637 0.0277

SER 1637 PRO 1638 0.0216

PRO 1638 SER 1639 0.0185

SER 1639 LEU 1640 0.0292

LEU 1640 SER 1641 0.0130

SER 1641 THR 1642 0.0289

THR 1642 ASN 1643 0.0261

ASN 1643 SER 1644 0.0089

SER 1644 TRP 1645 0.0384

TRP 1645 GLU 1646 0.0287

GLU 1646 LYS 1647 0.0118

LYS 1647 VAL 1648 0.0201

VAL 1648 LEU 1649 0.0283

LEU 1649 LYS 1650 0.0270

LYS 1650 LYS 1651 0.0090

LYS 1651 THR 1652 0.0271

THR 1652 GLY 1653 0.0291

GLY 1653 PHE 1654 0.0018

PHE 1654 ASP 1655 0.0190

ASP 1655 GLY 1656 0.0173

GLY 1656 LEU 1657 0.0077

LEU 1657 ASP 1658 0.0242

ASP 1658 ILE 1659 0.0114

ILE 1659 GLU 1660 0.0245

GLU 1660 LEU 1661 0.0114

LEU 1661 ARG 1662 0.0248

ARG 1662 ASP 1663 0.0246

ASP 1663 CYS 1664 0.0094

CYS 1664 ASP 1665 0.0252

ASP 1665 SER 1666 0.0290

SER 1666 ASP 1667 0.0182

ASP 1667 GLU 1668 0.0275

GLU 1668 PHE 1669 0.0288

PHE 1669 TYR 1670 0.0157

TYR 1670 SER 1671 0.0074

SER 1671 PHE 1672 0.0230

PHE 1672 SER 1673 0.0268

SER 1673 VAL 1674 0.0269

VAL 1674 MET 1675 0.0160

MET 1675 MET 1676 0.0226

MET 1676 ALA 1677 0.0130

ALA 1677 THR 1678 0.0155

THR 1678 ALA 1679 -0.0001

ALA 1679 SER 1680 0.0214

SER 1680 SER 1681 0.0207

SER 1681 THR 1682 0.0165

THR 1682 ILE 1683 0.0176

ILE 1683 ALA 1684 0.0098

ALA 1684 SER 1685 0.0220

SER 1685 SER 1686 0.0228

SER 1686 SER 1687 0.0226

SER 1687 MET 1688 0.0120

MET 1688 ALA 1689 0.0164

ALA 1689 PHE 1690 0.0006

PHE 1690 ALA 1691 0.0099

ALA 1691 ILE 1692 0.0003

ILE 1692 VAL 1693 0.0317

VAL 1693 TYR 1694 0.0011

TYR 1694 GLY 1695 0.0166

GLY 1695 GLU 1696 0.0133

GLU 1696 VAL 1697 0.0166

VAL 1697 PRO 1698 0.0165

PRO 1698 LEU 1699 0.0223

LEU 1699 PRO 1700 0.0180

PRO 1700 ASP 1701 0.0133

ASP 1701 GLN 1702 0.0219

GLN 1702 PHE 1703 0.0215

PHE 1703 LEU 1704 0.0068

LEU 1704 ASP 1705 0.0198

ASP 1705 ASP 1706 0.0212

ASP 1706 MET 1707 0.0173

MET 1707 LYS 1708 0.0081

LYS 1708 THR 1709 0.0229

THR 1709 ALA 1710 0.0220

ALA 1710 ILE 1711 0.0106

ILE 1711 SER 1712 0.0145

SER 1712 SER 1713 0.0218

SER 1713 SER 1714 0.0202

SER 1714 ALA 1715 0.0121

ALA 1715 VAL 1716 0.0099

VAL 1716 SER 1717 0.0194

SER 1717 ASP 1718 0.0064

ASP 1718 PRO 1719 0.0174

PRO 1719 VAL 1720 0.0218

VAL 1720 VAL 1721 0.0018

VAL 1721 GLY 1722 0.0212

GLY 1722 HIS 1723 0.0137

HIS 1723 LEU 1724 0.0205

LEU 1724 ASP 1725 0.0305

ASP 1725 SER 1726 0.0153

SER 1726 ILE 1727 0.0175

ILE 1727 ASP 1728 0.0009

ASP 1728 ALA 1729 0.0224

ALA 1729 THR 1730 0.0010

THR 1730 GLY 1731 0.0172

GLY 1731 LYS 1732 0.0082

LYS 1732 PHE 1733 0.0159

PHE 1733 CYS 1734 0.0034

CYS 1734 ILE 1735 0.0041

ILE 1735 PHE 1736 0.0132

PHE 1736 ILE 1737 0.0026

ILE 1737 GLU 1738 0.0127

GLU 1738 ASP 1739 0.0030

ASP 1739 PRO 1740 0.0139

PRO 1740 GLU 1741 0.0181

GLU 1741 THR 1742 0.0113

THR 1742 ASP 1743 0.0199

ASP 1743 ILE 1744 0.0083

ILE 1744 LEU 1745 0.0207

LEU 1745 SER 1746 0.0046

SER 1746 SER 1747 0.0227

SER 1747 PRO 1748 0.0070

PRO 1748 ASP 1749 0.0223

ASP 1749 GLU 1750 0.0052

GLU 1750 LYS 1751 0.0207

LYS 1751 SER 1752 0.0210

SER 1752 TYR 1753 0.0191

TYR 1753 ALA 1754 0.0056

ALA 1754 SER 1755 0.0227

SER 1755 ILE 1756 0.0225

ILE 1756 GLN 1757 0.0011

GLN 1757 LYS 1758 0.0153

LYS 1758 LEU 1759 0.0207

LEU 1759 VAL 1760 0.0211

VAL 1760 THR 1761 0.0068

THR 1761 ARG 1762 0.0197

ARG 1762 CYS 1763 0.0207

CYS 1763 LYS 1764 0.0138

LYS 1764 GLY 1765 0.0082

GLY 1765 LEU 1766 0.0002

LEU 1766 ILE 1767 0.0084

ILE 1767 TRP 1768 0.0081

TRP 1768 VAL 1769 0.0074

VAL 1769 SER 1770 0.0051

SER 1770 ARG 1771 0.0037

ARG 1771 GLY 1772 0.0166

GLY 1772 GLY 1773 0.0178

GLY 1773 ALA 1774 0.0177

ALA 1774 MET 1775 0.0163

MET 1775 HIS 1776 0.0015

HIS 1776 GLY 1777 0.0209

GLY 1777 THR 1778 0.0099

THR 1778 ARG 1779 0.0177

ARG 1779 PRO 1780 0.0182

PRO 1780 ASN 1781 0.0171

ASN 1781 SER 1782 0.0152

SER 1782 SER 1783 0.0172

SER 1783 LEU 1784 0.0176

LEU 1784 LYS 1785 0.0100

LYS 1785 THR 1786 0.0207

THR 1786 GLY 1787 0.0210

GLY 1787 LEU 1788 0.0140

LEU 1788 LEU 1789 0.0212

LEU 1789 ARG 1790 0.0222

ARG 1790 THR 1791 0.0179

THR 1791 LEU 1792 0.0167

LEU 1792 ARG 1793 0.0189

ARG 1793 LEU 1794 0.0191

LEU 1794 GLU 1795 0.0205

GLU 1795 TYR 1796 0.0186

TYR 1796 THR 1797 0.0201

THR 1797 GLU 1798 0.0170

GLU 1798 LYS 1799 0.0071

LYS 1799 ARG 1800 0.0122

ARG 1800 PHE 1801 0.0040

PHE 1801 ILE 1802 0.0106

ILE 1802 SER 1803 0.0006

SER 1803 LEU 1804 0.0153

LEU 1804 ASP 1805 -0.0023

ASP 1805 LEU 1806 0.0171

LEU 1806 ASP 1807 0.0053

ASP 1807 SER 1808 0.0100

SER 1808 ALA 1809 0.0128

ALA 1809 ARG 1810 0.0181

ARG 1810 PRO 1811 0.0225

PRO 1811 GLN 1812 0.0141

GLN 1812 TRP 1813 0.0142

TRP 1813 ASN 1814 0.0226

ASN 1814 HIS 1815 0.0109

HIS 1815 ASP 1816 0.0226

ASP 1816 SER 1817 0.0213

SER 1817 ILE 1818 0.0092

ILE 1818 THR 1819 0.0211

THR 1819 THR 1820 0.0226

THR 1820 ILE 1821 0.0123

ILE 1821 ASN 1822 0.0122

ASN 1822 GLU 1823 0.0237

GLU 1823 VAL 1824 0.0232

VAL 1824 LEU 1825 0.0131

LEU 1825 CYS 1826 0.0186

CYS 1826 GLY 1827 0.0238

GLY 1827 ALA 1828 0.0203

ALA 1828 LEU 1829 0.0114

LEU 1829 ALA 1830 0.0225

ALA 1830 GLN 1831 0.0214

GLN 1831 ASN 1832 0.0002

ASN 1832 ALA 1833 0.0187

ALA 1833 ASP 1834 0.0231

ASP 1834 SER 1835 0.0011

SER 1835 SER 1836 0.0237

SER 1836 ILE 1837 0.0031

ILE 1837 LYS 1838 0.0198

LYS 1838 ASP 1839 0.0012

ASP 1839 SER 1840 0.0213

SER 1840 GLU 1841 0.0001

GLU 1841 PHE 1842 0.0161

PHE 1842 ALA 1843 0.0007

ALA 1843 GLU 1844 0.0179

GLU 1844 GLN 1845 0.0068

GLN 1845 ASP 1846 0.0179

ASP 1846 GLY 1847 0.0071

GLY 1847 GLN 1848 0.0148

GLN 1848 LEU 1849 0.0109

LEU 1849 PHE 1850 0.0230

PHE 1850 VAL 1851 0.0123

VAL 1851 PRO 1852 0.0225

PRO 1852 ARG 1853 -0.0196

ARG 1853 ILE 1854 0.0193

ILE 1854 SER 1855 0.0186

SER 1855 CYS 1856 0.0189

CYS 1856 ASP 1857 0.0011

ASP 1857 ILE 1858 0.0195

ILE 1858 ALA 1859 0.0006

ALA 1859 ARG 1860 0.0193

ARG 1860 ASN 1861 0.0060

ASN 1861 GLU 1862 0.0158

GLU 1862 ASP 1863 0.0076

ASP 1863 LEU 1864 0.0130

LEU 1864 SER 1865 0.0141

SER 1865 SER 1866 0.0065

SER 1866 ASP 1867 0.0196

ASP 1867 SER 1868 0.0070

SER 1868 ASN 1869 0.1105

ASN 1869 SER 1870 0.0013

SER 1870 PRO 1871 0.0007

PRO 1871 ALA 1872 0.0009

ALA 1872 GLN 1873 0.0014

GLN 1873 MET 1874 0.0001

MET 1874 GLU 1875 0.0017

GLU 1875 PRO 1876 0.0008

PRO 1876 PHE 1877 0.0017

PHE 1877 HIS 1878 0.0016

HIS 1878 GLN 1879 0.0006

GLN 1879 PRO 1880 0.0017

PRO 1880 GLY 1881 0.0005

GLY 1881 LYS 1882 0.0015

LYS 1882 LEU 1883 0.0018

LEU 1883 LEU 1884 0.0017

LEU 1884 GLN 1885 -0.0065

GLN 1885 MET 1886 0.0014

MET 1886 GLY 1887 0.0011

GLY 1887 ILE 1888 0.0010

ILE 1888 LYS 1889 -0.0000

LYS 1889 THR 1890 0.0017

THR 1890 PRO 1891 0.0004

PRO 1891 GLY 1892 0.0013

GLY 1892 LEU 1893 0.0013

LEU 1893 ILE 1894 0.0006

ILE 1894 ASP 1895 0.0010

ASP 1895 THR 1896 0.0012

THR 1896 LEU 1897 0.0006

LEU 1897 GLN 1898 0.0012

GLN 1898 PHE 1899 0.0014

PHE 1899 SER 1900 0.0010

SER 1900 LYS 1901 -0.0158

LYS 1901 THR 1902 0.0013

THR 1902 ASP 1903 0.0016

ASP 1903 ALA 1904 0.0005

ALA 1904 THR 1905 0.0014

THR 1905 ASP 1906 0.0008

ASP 1906 ASN 1907 0.0011

ASN 1907 LEU 1908 0.0003

LEU 1908 PRO 1909 0.0013

PRO 1909 ASN 1910 0.0004

ASN 1910 ASP 1911 0.0011

ASP 1911 TYR 1912 0.0011

TYR 1912 ILE 1913 0.0015

ILE 1913 GLU 1914 0.0010

GLU 1914 ILE 1915 0.0012

ILE 1915 GLU 1916 0.0011

GLU 1916 PRO 1917 -0.0084

PRO 1917 LYS 1918 0.0014

LYS 1918 ALA 1919 0.0013

ALA 1919 PHE 1920 0.0013

PHE 1920 GLY 1921 0.0015

GLY 1921 LEU 1922 0.0006

LEU 1922 ASN 1923 0.0015

ASN 1923 PHE 1924 0.0014

PHE 1924 ARG 1925 0.0014

ARG 1925 ASP 1926 0.0010

ASP 1926 VAL 1927 0.0012

VAL 1927 MET 1928 0.0013

MET 1928 VAL 1929 0.0012

VAL 1929 ALA 1930 0.0008

ALA 1930 MET 1931 0.0013

MET 1931 GLY 1932 0.0017

GLY 1932 GLN 1933 -0.0226

GLN 1933 LEU 1934 0.0013

LEU 1934 GLU 1935 0.0014

GLU 1935 GLU 1936 0.0014

GLU 1936 SER 1937 0.0013

SER 1937 ILE 1938 0.0005

ILE 1938 MET 1939 0.0016

MET 1939 GLY 1940 0.0009

GLY 1940 PHE 1941 0.0001

PHE 1941 GLU 1942 0.0009

GLU 1942 CYS 1943 0.0020

CYS 1943 ALA 1944 0.0009

ALA 1944 GLY 1945 0.0018

GLY 1945 VAL 1946 0.0015

VAL 1946 VAL 1947 0.0018

VAL 1947 ARG 1948 0.0010

ARG 1948 ARG 1949 0.0117

ARG 1949 VAL 1950 0.0009

VAL 1950 GLY 1951 0.0012

GLY 1951 PRO 1952 0.0011

PRO 1952 SER 1953 0.0009

SER 1953 SER 1954 0.0013

SER 1954 ALA 1955 0.0012

ALA 1955 GLY 1956 0.0006

GLY 1956 HIS 1957 0.0014

HIS 1957 ASN 1958 0.0012

ASN 1958 ILE 1959 0.0002

ILE 1959 LYS 1960 0.0012

LYS 1960 VAL 1961 0.0006

VAL 1961 GLY 1962 0.0014

GLY 1962 ASP 1963 0.0008

ASP 1963 ARG 1964 0.0013

ARG 1964 VAL 1965 0.0023

VAL 1965 CYS 1966 0.0011

CYS 1966 ALA 1967 0.0011

ALA 1967 LEU 1968 0.0010

LEU 1968 LEU 1969 0.0000

LEU 1969 GLY 1970 0.0009

GLY 1970 GLY 1971 0.0010

GLY 1971 GLN 1972 0.0009

GLN 1972 TRP 1973 0.0014

TRP 1973 THR 1974 0.0016

THR 1974 ASN 1975 0.0012

ASN 1975 THR 1976 0.0010

THR 1976 VAL 1977 0.0010

VAL 1977 ARG 1978 0.0013

ARG 1978 VAL 1979 0.0006

VAL 1979 HIS 1980 0.0008

HIS 1980 TRP 1981 0.0027

TRP 1981 HIS 1982 0.0011

HIS 1982 SER 1983 0.0012

SER 1983 VAL 1984 0.0012

VAL 1984 ALA 1985 0.0006

ALA 1985 PRO 1986 0.0012

PRO 1986 ILE 1987 0.0012

ILE 1987 PRO 1988 0.0007

PRO 1988 GLN 1989 0.0011

GLN 1989 ALA 1990 0.0015

ALA 1990 MET 1991 0.0009

MET 1991 ASP 1992 0.0003

ASP 1992 TRP 1993 0.0004

TRP 1993 GLU 1994 0.0012

GLU 1994 THR 1995 0.0001

THR 1995 ALA 1996 0.0014

ALA 1996 ALA 1997 0.0020

ALA 1997 SER 1998 0.0009

SER 1998 ILE 1999 0.0005

ILE 1999 PRO 2000 0.0010

PRO 2000 ILE 2001 0.0011

ILE 2001 VAL 2002 0.0009

VAL 2002 PHE 2003 0.0002

PHE 2003 VAL 2004 0.0010

VAL 2004 THR 2005 0.0011

THR 2005 ALA 2006 0.0004

ALA 2006 TYR 2007 0.0008

TYR 2007 ILE 2008 0.0012

ILE 2008 SER 2009 0.0013

SER 2009 LEU 2010 0.0003

LEU 2010 VAL 2011 0.0007

VAL 2011 LYS 2012 0.0010

LYS 2012 ILE 2013 -0.0045

ILE 2013 ALA 2014 0.0013

ALA 2014 ARG 2015 0.0008

ARG 2015 MET 2016 0.0013

MET 2016 GLN 2017 0.0004

GLN 2017 ALA 2018 0.0012

ALA 2018 GLY 2019 0.0013

GLY 2019 GLU 2020 0.0009

GLU 2020 THR 2021 0.0005

THR 2021 VAL 2022 0.0000

VAL 2022 LEU 2023 0.0004

LEU 2023 ILE 2024 0.0004

ILE 2024 HIS 2025 0.0003

HIS 2025 ALA 2026 0.0005

ALA 2026 ALA 2027 0.0009

ALA 2027 SER 2028 0.0006

SER 2028 GLY 2029 -0.0082

GLY 2029 GLY 2030 0.0012

GLY 2030 VAL 2031 0.0008

VAL 2031 GLY 2032 0.0010

GLY 2032 GLN 2033 0.0009

GLN 2033 ALA 2034 0.0009

ALA 2034 ALA 2035 0.0007

ALA 2035 ILE 2036 0.0011

ILE 2036 ILE 2037 0.0009

ILE 2037 LEU 2038 0.0010

LEU 2038 ALA 2039 0.0008

ALA 2039 LYS 2040 0.0010

LYS 2040 HIS 2041 0.0011

HIS 2041 VAL 2042 0.0008

VAL 2042 GLY 2043 0.0010

GLY 2043 ALA 2044 0.0009

ALA 2044 GLU 2045 0.0123

GLU 2045 ILE 2046 -0.0000

ILE 2046 PHE 2047 0.0009

PHE 2047 ALA 2048 0.0000

ALA 2048 THR 2049 0.0002

THR 2049 VAL 2050 0.0003

VAL 2050 GLY 2051 0.0001

GLY 2051 THR 2052 0.0012

THR 2052 ASP 2053 0.0013

ASP 2053 GLU 2054 0.0012

GLU 2054 LYS 2055 0.0010

LYS 2055 ARG 2056 0.0007

ARG 2056 ASP 2057 0.0012

ASP 2057 LEU 2058 0.0013

LEU 2058 LEU 2059 0.0004

LEU 2059 ILE 2060 0.0011

ILE 2060 LYS 2061 0.0024

LYS 2061 GLU 2062 0.0012

GLU 2062 TYR 2063 0.0005

TYR 2063 LYS 2064 0.0012

LYS 2064 ILE 2065 0.0015

ILE 2065 PRO 2066 0.0015

PRO 2066 ASP 2067 0.0007

ASP 2067 ASP 2068 0.0009

ASP 2068 HIS 2069 0.0013

HIS 2069 ILE 2070 0.0002

ILE 2070 PHE 2071 0.0009

PHE 2071 SER 2072 0.0004

SER 2072 SER 2073 0.0015

SER 2073 ARG 2074 0.0007

ARG 2074 ASN 2075 0.0009

ASN 2075 ALA 2076 0.0002

ALA 2076 LEU 2077 -0.0112

LEU 2077 PHE 2078 0.0013

PHE 2078 ALA 2079 0.0005

ALA 2079 LYS 2080 0.0013

LYS 2080 SER 2081 0.0015

SER 2081 ILE 2082 0.0011

ILE 2082 ARG 2083 0.0005

ARG 2083 GLN 2084 0.0016

GLN 2084 ARG 2085 0.0012

ARG 2085 THR 2086 0.0008

THR 2086 ASN 2087 0.0007

ASN 2087 GLY 2088 0.0014

GLY 2088 LYS 2089 0.0015

LYS 2089 GLY 2090 0.0002

GLY 2090 VAL 2091 0.0011

VAL 2091 ASP 2092 0.0011

ASP 2092 VAL 2093 0.0120

VAL 2093 VAL 2094 0.0003

VAL 2094 LEU 2095 0.0003

LEU 2095 ASN 2096 0.0009

ASN 2096 CYS 2097 0.0001

CYS 2097 LEU 2098 0.0012

LEU 2098 ALA 2099 0.0013

ALA 2099 GLY 2100 0.0014

GLY 2100 GLY 2101 0.0008

GLY 2101 LEU 2102 0.0013

LEU 2102 LEU 2103 0.0010

LEU 2103 GLN 2104 0.0007

GLN 2104 GLU 2105 0.0012

GLU 2105 SER 2106 0.0012

SER 2106 PHE 2107 0.0007

PHE 2107 ASP 2108 0.0010

ASP 2108 CYS 2109 0.0076

CYS 2109 LEU 2110 0.0014

LEU 2110 ALA 2111 0.0001

ALA 2111 ASP 2112 0.0010

ASP 2112 PHE 2113 0.0011

PHE 2113 GLY 2114 0.0003

GLY 2114 ARG 2115 0.0004

ARG 2115 PHE 2116 0.0006

PHE 2116 ILE 2117 0.0003

ILE 2117 GLU 2118 0.0003

GLU 2118 ILE 2119 0.0003

ILE 2119 GLY 2120 0.0009

GLY 2120 LYS 2121 0.0010

LYS 2121 ARG 2122 0.0013

ARG 2122 ASP 2123 0.0005

ASP 2123 ILE 2124 0.0014

ILE 2124 GLU 2125 0.0082

GLU 2125 LEU 2126 0.0012

LEU 2126 ASN 2127 0.0002

ASN 2127 HIS 2128 0.0011

HIS 2128 CYS 2129 0.0001

CYS 2129 LEU 2130 0.0008

LEU 2130 ASN 2131 0.0002

ASN 2131 MET 2132 0.0007

MET 2132 GLY 2133 0.0005

GLY 2133 MET 2134 0.0011

MET 2134 PHE 2135 0.0014

PHE 2135 ALA 2136 0.0002

ALA 2136 ARG 2137 0.0013

ARG 2137 SER 2138 0.0010

SER 2138 ALA 2139 0.0002

ALA 2139 THR 2140 0.0004

THR 2140 PHE 2141 -0.0137

PHE 2141 THR 2142 0.0006

THR 2142 ALA 2143 -0.0001

ALA 2143 VAL 2144 0.0010

VAL 2144 ASP 2145 0.0002

ASP 2145 LEU 2146 0.0012

LEU 2146 ILE 2147 0.0005

ILE 2147 ALA 2148 0.0009

ALA 2148 ILE 2149 0.0009

ILE 2149 GLY 2150 0.0005

GLY 2150 ARG 2151 0.0010

ARG 2151 ASP 2152 0.0005

ASP 2152 ARG 2153 0.0006

ARG 2153 SER 2154 0.0009

SER 2154 TYR 2155 0.0005

TYR 2155 MET 2156 0.0009

MET 2156 PHE 2157 0.0015

PHE 2157 ALA 2158 0.0009

ALA 2158 GLU 2159 0.0003

GLU 2159 ALA 2160 0.0012

ALA 2160 LEU 2161 0.0009

LEU 2161 PRO 2162 0.0008

PRO 2162 LYS 2163 0.0004

LYS 2163 ILE 2164 0.0012

ILE 2164 MET 2165 0.0011

MET 2165 THR 2166 0.0000

THR 2166 LEU 2167 0.0013

LEU 2167 LEU 2168 0.0005

LEU 2168 GLN 2169 0.0013

GLN 2169 GLU 2170 0.0001

GLU 2170 LYS 2171 0.0012

LYS 2171 ALA 2172 0.0010

ALA 2172 ILE 2173 -0.0141

ILE 2173 ARG 2174 0.0006

ARG 2174 PRO 2175 -0.0002

PRO 2175 VAL 2176 0.0008

VAL 2176 THR 2177 0.0009

THR 2177 PRO 2178 0.0006

PRO 2178 ILE 2179 0.0007

ILE 2179 SER 2180 0.0002

SER 2180 ILE 2181 0.0008

ILE 2181 TYR 2182 0.0003

TYR 2182 LYS 2183 0.0005

LYS 2183 ILE 2184 0.0010

ILE 2184 GLY 2185 0.0005

GLY 2185 ASP 2186 0.0007

ASP 2186 ILE 2187 0.0010

ILE 2187 GLU 2188 0.0006

GLU 2188 THR 2189 -0.0217

THR 2189 ALA 2190 0.0004

ALA 2190 PHE 2191 0.0010

PHE 2191 ARG 2192 0.0011

ARG 2192 LEU 2193 0.0004

LEU 2193 MET 2194 0.0008

MET 2194 GLN 2195 0.0008

GLN 2195 ALA 2196 0.0009

ALA 2196 GLY 2197 0.0002

GLY 2197 LYS 2198 0.0008

LYS 2198 HIS 2199 0.0009

HIS 2199 MET 2200 0.0003

MET 2200 GLY 2201 0.0011

GLY 2201 LYS 2202 0.0004

LYS 2202 ILE 2203 0.0003

ILE 2203 VAL 2204 0.0009

VAL 2204 ILE 2205 -0.0460

ILE 2205 THR 2206 0.0011

THR 2206 ALA 2207 0.0008

ALA 2207 PRO 2208 0.0010

PRO 2208 GLU 2209 0.0009

GLU 2209 ASP 2210 0.0007

ASP 2210 ALA 2211 0.0012

ALA 2211 MET 2212 0.0002

MET 2212 VAL 2213 0.0009

VAL 2213 PRO 2214 0.0003

PRO 2214 VAL 2215 0.0009

VAL 2215 ILE 2216 0.0001

ILE 2216 THR 2217 0.0010

THR 2217 ARG 2218 0.0007

ARG 2218 PRO 2219 0.0004

PRO 2219 PRO 2220 0.0011

PRO 2220 LYS 2221 -0.0514

LYS 2221 LEU 2222 0.0163

LEU 2222 GLN 2223 0.0043

GLN 2223 LEU 2224 0.0162

LEU 2224 ARG 2225 0.0024

ARG 2225 PRO 2226 0.0161

PRO 2226 ASP 2227 0.0083

ASP 2227 ALA 2228 0.0102

ALA 2228 SER 2229 0.0075

SER 2229 TYR 2230 0.0030

TYR 2230 LEU 2231 0.0120

LEU 2231 ILE 2232 -0.0000

ILE 2232 VAL 2233 0.0123

VAL 2233 GLY 2234 0.0044

GLY 2234 GLY 2235 0.0138

GLY 2235 LEU 2236 0.0104

LEU 2236 GLY 2237 -0.0279

GLY 2237 GLY 2238 0.0114

GLY 2238 ILE 2239 0.0114

ILE 2239 GLY 2240 0.0040

GLY 2240 ARG 2241 0.0142

ARG 2241 SER 2242 0.0139

SER 2242 LEU 2243 0.0057

LEU 2243 CYS 2244 0.0096

CYS 2244 LYS 2245 0.0137

LYS 2245 ASN 2246 0.0142

ASN 2246 PHE 2247 0.0037

PHE 2247 VAL 2248 0.0126

VAL 2248 GLU 2249 0.0129

GLU 2249 ASN 2250 0.0115

ASN 2250 GLY 2251 0.0036

GLY 2251 ALA 2252 0.0143

ALA 2252 ARG 2253 0.0076

ARG 2253 SER 2254 0.0163

SER 2254 LEU 2255 0.0047

LEU 2255 VAL 2256 0.0164

VAL 2256 LEU 2257 0.0017

LEU 2257 LEU 2258 0.0156

LEU 2258 SER 2259 0.0049

SER 2259 ARG 2260 0.0149

ARG 2260 ASN 2261 0.0156

ASN 2261 ALA 2262 0.0084

ALA 2262 ASN 2263 0.0160

ASN 2263 VAL 2264 0.0055

VAL 2264 SER 2265 0.0102

SER 2265 GLN 2266 0.0079

GLN 2266 GLN 2267 0.0101

GLN 2267 SER 2268 0.0078

SER 2268 GLY 2269 0.0271

GLY 2269 GLU 2270 0.0158

GLU 2270 PHE 2271 0.0158

PHE 2271 LEU 2272 0.0038

LEU 2272 ASP 2273 0.0164

ASP 2273 GLU 2274 0.0155

GLU 2274 LEU 2275 0.0096

LEU 2275 ARG 2276 0.0084

ARG 2276 SER 2277 0.0164

SER 2277 THR 2278 0.0152

THR 2278 GLY 2279 0.0043

GLY 2279 CYS 2280 0.0163

CYS 2280 ILE 2281 0.0151

ILE 2281 VAL 2282 0.0062

VAL 2282 GLY 2283 0.0166

GLY 2283 VAL 2284 0.0043

VAL 2284 VAL 2285 0.0688

VAL 2285 ASP 2286 0.0103

ASP 2286 CYS 2287 0.0164

CYS 2287 ASP 2288 0.0097

ASP 2288 ILE 2289 0.0146

ILE 2289 SER 2290 0.0133

SER 2290 SER 2291 0.0083

SER 2291 LYS 2292 0.0045

LYS 2292 THR 2293 0.0122

THR 2293 GLN 2294 0.0140

GLN 2294 VAL 2295 0.0156

VAL 2295 GLU 2296 0.0020

GLU 2296 ALA 2297 0.0159

ALA 2297 THR 2298 0.0134

THR 2298 MET 2299 0.0108

MET 2299 LEU 2300 0.0057

LEU 2300 ARG 2301 0.0162

ARG 2301 LEU 2302 0.0159

LEU 2302 LYS 2303 0.0040

LYS 2303 LYS 2304 0.0134

LYS 2304 ASP 2305 0.0104

ASP 2305 MET 2306 0.0150

MET 2306 LEU 2307 0.0146

LEU 2307 PRO 2308 0.0166

PRO 2308 ILE 2309 0.0025

ILE 2309 ARG 2310 0.0161

ARG 2310 GLY 2311 0.0001

GLY 2311 ILE 2312 0.0065

ILE 2312 VAL 2313 0.0003

VAL 2313 HIS 2314 0.0118

HIS 2314 ALA 2315 0.0042

ALA 2315 GLY 2316 0.0163

GLY 2316 MET 2317 0.0453

MET 2317 VAL 2318 0.0136

VAL 2318 LEU 2319 0.0009

LEU 2319 GLN 2320 0.0162

GLN 2320 ASP 2321 0.0054

ASP 2321 SER 2322 0.0157

SER 2322 VAL 2323 0.0158

VAL 2323 PHE 2324 0.0137

PHE 2324 GLU 2325 0.0139

GLU 2325 ARG 2326 0.0215

ARG 2326 MET 2327 0.0025

MET 2327 SER 2328 0.0150

SER 2328 LEU 2329 0.0034

LEU 2329 ASP 2330 0.0195

ASP 2330 ASP 2331 0.0154

ASP 2331 TYR 2332 0.0192

TYR 2332 ASN 2333 0.0043

ASN 2333 THR 2334 0.0200

THR 2334 ALA 2335 0.0187

ALA 2335 ILE 2336 0.0129

ILE 2336 ARG 2337 0.0059

ARG 2337 PRO 2338 0.0191

PRO 2338 LYS 2339 0.0195

LYS 2339 VAL 2340 0.0177

VAL 2340 GLN 2341 0.0100

GLN 2341 GLY 2342 0.0192

GLY 2342 SER 2343 0.0200

SER 2343 TRP 2344 0.0140

TRP 2344 ASN 2345 0.0137

ASN 2345 LEU 2346 0.0200

LEU 2346 HIS 2347 0.0193

HIS 2347 SER 2348 0.0112

SER 2348 GLY 2349 0.0181

GLY 2349 LEU 2350 0.0171

LEU 2350 SER 2351 0.0148

SER 2351 ASP 2352 0.0039

ASP 2352 CYS 2353 0.0159

CYS 2353 ASP 2354 0.0179

ASP 2354 LEU 2355 0.0032

LEU 2355 ASP 2356 0.0167

ASP 2356 PHE 2357 0.0016

PHE 2357 PHE 2358 0.0122

PHE 2358 ILE 2359 0.0014

ILE 2359 MET 2360 0.0081

MET 2360 LEU 2361 0.0044

LEU 2361 SER 2362 0.0117

SER 2362 SER 2363 0.0003

SER 2363 LEU 2364 0.0099

LEU 2364 ALA 2365 0.0185

ALA 2365 GLY 2366 0.0113

GLY 2366 VAL 2367 0.0197

VAL 2367 SER 2368 0.0006

SER 2368 GLY 2369 0.0208

GLY 2369 SER 2370 0.0165

SER 2370 ALA 2371 0.0109

ALA 2371 SER 2372 0.0192

SER 2372 GLN 2373 0.0022

GLN 2373 ALA 2374 0.0193

ALA 2374 ASN 2375 0.0070

ASN 2375 TYR 2376 0.0202

TYR 2376 THR 2377 0.0206

THR 2377 ALA 2378 0.0136

ALA 2378 GLY 2379 0.0108

GLY 2379 GLY 2380 0.0210

GLY 2380 ALA 2381 0.0157

ALA 2381 TYR 2382 0.0062

TYR 2382 GLN 2383 0.0162

GLN 2383 ASP 2384 0.0189

ASP 2384 ALA 2385 0.0165

ALA 2385 LEU 2386 0.0077

LEU 2386 ALA 2387 0.0196

ALA 2387 LYS 2388 0.0200

LYS 2388 TYR 2389 0.0128

TYR 2389 ARG 2390 0.0116

ARG 2390 ARG 2391 0.0201

ARG 2391 ALA 2392 0.0195

ALA 2392 GLN 2393 0.0073

GLN 2393 GLY 2394 0.0180

GLY 2394 LEU 2395 0.0188

LEU 2395 SER 2396 0.0148

SER 2396 ALA 2397 0.0052

ALA 2397 VAL 2398 0.0045

VAL 2398 SER 2399 0.0033

SER 2399 ILE 2400 0.0104

ILE 2400 ASP 2401 0.0022

ASP 2401 LEU 2402 0.0164

LEU 2402 GLY 2403 0.0021

GLY 2403 MET 2404 0.0136

MET 2404 VAL 2405 0.0124

VAL 2405 GLN 2406 0.0115

GLN 2406 SER 2407 0.0124

SER 2407 VAL 2408 0.0117

VAL 2408 GLY 2409 0.0177

GLY 2409 TYR 2410 0.0085

TYR 2410 VAL 2411 0.0089

VAL 2411 ALA 2412 0.0174

ALA 2412 GLU 2413 0.0235

GLU 2413 THR 2414 0.0058

THR 2414 LYS 2415 0.0033

LYS 2415 GLY 2416 0.0109

GLY 2416 VAL 2417 0.0100

VAL 2417 ALA 2418 0.0172

ALA 2418 GLU 2419 0.0013

GLU 2419 ARG 2420 0.0175

ARG 2420 LEU 2421 0.0071

LEU 2421 VAL 2422 0.0159

VAL 2422 ARG 2423 0.0036

ARG 2423 MET 2424 0.0137

MET 2424 GLY 2425 0.0140

GLY 2425 TYR 2426 0.0041

TYR 2426 SER 2427 0.0148

SER 2427 PRO 2428 0.0143

PRO 2428 ILE 2429 0.0127

ILE 2429 SER 2430 0.0127

SER 2430 GLU 2431 0.0051

GLU 2431 MET 2432 0.0112

MET 2432 GLU 2433 0.0136

GLU 2433 VAL 2434 0.0129

VAL 2434 LEU 2435 0.0042

LEU 2435 LYS 2436 0.0143

LYS 2436 ILE 2437 0.0141

ILE 2437 VAL 2438 0.0077

VAL 2438 GLU 2439 0.0089

GLU 2439 HIS 2440 0.0139

HIS 2440 ALA 2441 0.0142

ALA 2441 ILE 2442 0.0033

ILE 2442 THR 2443 0.0134

THR 2443 ASN 2444 0.0127

ASN 2444 PRO 2445 -0.0275

PRO 2445 PRO 2446 0.0160

PRO 2446 PRO 2447 0.0119

PRO 2447 GLU 2448 0.0170

GLU 2448 ALA 2449 0.0197

ALA 2449 SER 2450 0.0026

SER 2450 SER 2451 0.0207

SER 2451 ALA 2452 0.0193

ALA 2452 GLN 2453 0.0021

GLN 2453 ILE 2454 0.0165

ILE 2454 ILE 2455 0.0003

ILE 2455 THR 2456 0.0166

THR 2456 GLY 2457 0.0045

GLY 2457 ILE 2458 0.0130

ILE 2458 SER 2459 0.0101

SER 2459 THR 2460 0.0207

THR 2460 LYS 2461 0.0176

LYS 2461 PRO 2462 0.0033

PRO 2462 GLY 2463 0.0137

GLY 2463 ARG 2464 0.0130

ARG 2464 HIS 2465 0.0089

HIS 2465 TRP 2466 0.0213

TRP 2466 THR 2467 0.0041

THR 2467 GLU 2468 0.0219

GLU 2468 SER 2469 0.0032

SER 2469 SER 2470 0.0220

SER 2470 TRP 2471 0.0003

TRP 2471 LEU 2472 0.0219

LEU 2472 GLN 2473 0.0157

GLN 2473 ASP 2474 0.0082

ASP 2474 ALA 2475 0.0182

ALA 2475 ARG 2476 0.0056

ARG 2476 PHE 2477 0.0126

PHE 2477 ALA 2478 0.0172

ALA 2478 THR 2479 0.0130

THR 2479 LEU 2480 0.0222

LEU 2480 ARG 2481 -0.0000

ARG 2481 GLU 2482 0.0227

GLU 2482 ARG 2483 0.0141

ARG 2483 ALA 2484 0.0121

ALA 2484 ARG 2485 0.0110

ARG 2485 ASP 2486 0.0166

ASP 2486 VAL 2487 0.0224

VAL 2487 LYS 2488 0.0002

LYS 2488 GLU 2489 0.0217

GLU 2489 LEU 2490 0.0117

LEU 2490 SER 2491 0.0156

SER 2491 ASN 2492 0.0077

ASN 2492 SER 2493 0.0141

SER 2493 GLN 2494 0.0181

GLN 2494 ASN 989 -0.0304

ASN 989 LYS 990 0.0023

LYS 990 ALA 991 0.0024

ALA 991 HIS 992 0.0012

HIS 992 ARG 993 0.0021

ARG 993 GLN 994 0.0026

GLN 994 ARG 995 0.0019

ARG 995 VAL 996 0.0019

VAL 996 HIS 997 0.0016

HIS 997 PRO 998 0.0016

PRO 998 PRO 999 0.0026

PRO 999 HIS 1000 0.0021

HIS 1000 ASP 1001 0.0013

ASP 1001 LEU 1002 0.0019

LEU 1002 LEU 1003 0.0002

LEU 1003 GLY 1004 0.0025

GLY 1004 SER 1005 -0.0081

SER 1005 LEU 1006 0.0004

LEU 1006 ILE 1007 0.0011

ILE 1007 VAL 1008 0.0013

VAL 1008 GLY 1009 0.0001

GLY 1009 ARG 1010 0.0019

ARG 1010 ASP 1011 0.0018

ASP 1011 LEU 1012 0.0011

LEU 1012 ARG 1013 0.0019

ARG 1013 GLU 1014 0.0019

GLU 1014 PRO 1015 0.0010

PRO 1015 THR 1016 0.0016

THR 1016 TRP 1017 0.0007

TRP 1017 ARG 1018 0.0017

ARG 1018 HIS 1019 0.0001

HIS 1019 PHE 1020 0.0018

PHE 1020 ILE 1021 0.0448

ILE 1021 ARG 1022 0.0003

ARG 1022 VAL 1023 0.0015

VAL 1023 GLN 1024 0.0020

GLN 1024 ASP 1025 0.0018

ASP 1025 ILE 1026 0.0028

ILE 1026 PRO 1027 0.0010

PRO 1027 TRP 1028 0.0027

TRP 1028 ILE 1029 0.0020

ILE 1029 ARG 1030 0.0010

ARG 1030 ASP 1031 0.0032

ASP 1031 HIS 1032 0.0005

HIS 1032 VAL 1033 0.0031

VAL 1033 VAL 1034 0.0017

VAL 1034 GLN 1035 0.0029

GLN 1035 SER 1036 0.0014

SER 1036 ALA 1037 0.0457

ALA 1037 LEU 1038 0.0025

LEU 1038 VAL 1039 0.0011

VAL 1039 TYR 1040 0.0024

TYR 1040 PRO 1041 0.0024

PRO 1041 GLY 1042 0.0006

GLY 1042 ALA 1043 0.0021

ALA 1043 GLY 1044 0.0023

GLY 1044 PHE 1045 0.0000

PHE 1045 ILE 1046 0.0024

ILE 1046 CYS 1047 0.0012

CYS 1047 MET 1048 0.0016

MET 1048 ALA 1049 0.0008

ALA 1049 MET 1050 0.0020

MET 1050 GLU 1051 0.0022

GLU 1051 ALA 1052 0.0005

ALA 1052 MET 1053 0.0253

MET 1053 VAL 1054 0.0016

VAL 1054 GLN 1055 0.0024

GLN 1055 LEU 1056 0.0007

LEU 1056 HIS 1057 0.0027

HIS 1057 GLU 1058 0.0025

GLU 1058 LEU 1059 0.0008

LEU 1059 ARG 1060 0.0023

ARG 1060 ASP 1061 0.0020

ASP 1061 SER 1062 0.0028

SER 1062 GLN 1063 0.0028

GLN 1063 SER 1064 0.0003

SER 1064 ARG 1065 0.0031

ARG 1065 LYS 1066 0.0006

LYS 1066 VAL 1067 0.0031

VAL 1067 ALA 1068 0.0026

ALA 1068 GLY 1069 0.0213

GLY 1069 TYR 1070 0.0020

TYR 1070 ARG 1071 0.0016

ARG 1071 LEU 1072 0.0022

LEU 1072 ALA 1073 0.0016

ALA 1073 GLU 1074 0.0023

GLU 1074 VAL 1075 0.0012

VAL 1075 ASP 1076 0.0024

ASP 1076 ILE 1077 0.0011

ILE 1077 LEU 1078 0.0016

LEU 1078 ARG 1079 0.0013

ARG 1079 ALA 1080 0.0000

ALA 1080 MET 1081 0.0022

MET 1081 LEU 1082 0.0011

LEU 1082 ILE 1083 0.0017

ILE 1083 PRO 1084 0.0021

PRO 1084 ASP 1085 -0.0347

ASP 1085 THR 1086 0.0018

THR 1086 SER 1087 0.0020

SER 1087 GLU 1088 0.0002

GLU 1088 GLY 1089 0.0021

GLY 1089 LEU 1090 0.0007

LEU 1090 GLU 1091 0.0005

GLU 1091 ALA 1092 0.0023

ALA 1092 HIS 1093 0.0007

HIS 1093 ILE 1094 0.0021

ILE 1094 SER 1095 0.0002

SER 1095 LEU 1096 0.0019

LEU 1096 ARG 1097 0.0002

ARG 1097 PRO 1098 0.0017

PRO 1098 CYS 1099 0.0021

CYS 1099 SER 1100 0.0001

SER 1100 THR 1101 0.0045

THR 1101 LYS 1102 0.0022

LYS 1102 LEU 1103 0.0004

LEU 1103 LEU 1104 0.0021

LEU 1104 LEU 1105 0.0011

LEU 1105 THR 1106 0.0023

THR 1106 ASN 1107 0.0014

ASN 1107 GLU 1108 0.0024

GLU 1108 TRP 1109 0.0014

TRP 1109 TYR 1110 0.0018

TYR 1110 ASP 1111 0.0020

ASP 1111 PHE 1112 0.0007

PHE 1112 CYS 1113 0.0018

CYS 1113 VAL 1114 0.0004

VAL 1114 SER 1115 0.0023

SER 1115 SER 1116 0.0017

SER 1116 VAL 1117 0.0122

VAL 1117 GLY 1118 0.0016

GLY 1118 ASP 1119 0.0023

ASP 1119 ASP 1120 0.0008

ASP 1120 ASP 1121 0.0016

ASP 1121 LYS 1122 0.0023

LYS 1122 PHE 1123 0.0022

PHE 1123 VAL 1124 0.0013

VAL 1124 ASP 1125 0.0021

ASP 1125 HIS 1126 0.0009

HIS 1126 CYS 1127 0.0020

CYS 1127 ARG 1128 0.0008

ARG 1128 GLY 1129 0.0020

GLY 1129 ARG 1130 0.0017

ARG 1130 ILE 1131 0.0021

ILE 1131 THR 1132 0.0018

THR 1132 ILE 1133 0.0148

ILE 1133 GLU 1134 0.0030

GLU 1134 PHE 1135 0.0027

PHE 1135 ASP 1136 0.0020

ASP 1136 THR 1137 0.0018

THR 1137 SER 1138 0.0025

SER 1138 GLY 1139 0.0028

GLY 1139 SER 1140 0.0031

SER 1140 ALA 1141 0.0014

ALA 1141 ASP 1142 0.0022

ASP 1142 THR 1143 0.0020

THR 1143 PRO 1144 0.0007

PRO 1144 ARG 1145 0.0028

ARG 1145 THR 1146 0.0028

THR 1146 SER 1147 0.0000

SER 1147 LEU 1148 0.0028

LEU 1148 ARG 1149 -0.0541

ARG 1149 GLU 1150 0.0018

GLU 1150 ARG 1151 0.0014

ARG 1151 SER 1152 0.0025

SER 1152 ARG 1153 0.0031

ARG 1153 SER 1154 0.0015

SER 1154 THR 1155 0.0031

THR 1155 GLY 1156 0.0031

GLY 1156 LEU 1157 0.0025

LEU 1157 MET 1158 0.0028

MET 1158 ARG 1159 0.0031

ARG 1159 SER 1160 0.0022

SER 1160 VAL 1161 0.0023

VAL 1161 ASP 1162 0.0028

ASP 1162 PRO 1163 0.0027

PRO 1163 SER 1164 0.0032

SER 1164 ASN 1165 -0.0324

ASN 1165 LEU 1166 0.0021

LEU 1166 TYR 1167 0.0036

TYR 1167 SER 1168 0.0043

SER 1168 PHE 1169 0.0004

PHE 1169 LEU 1170 0.0040

LEU 1170 ARG 1171 0.0026

ARG 1171 ALA 1172 0.0043

ALA 1172 GLN 1173 0.0005

GLN 1173 GLY 1174 0.0043

GLY 1174 ILE 1175 0.0044

ILE 1175 TYR 1176 0.0005

TYR 1176 HIS 1177 0.0042

HIS 1177 GLY 1178 0.0004

GLY 1178 PRO 1179 0.0027

PRO 1179 ILE 1180 0.0039

ILE 1180 PHE 1181 0.0037

PHE 1181 GLN 1182 0.0028

GLN 1182 ASN 1183 0.0037

ASN 1183 LEU 1184 0.0033

LEU 1184 LYS 1185 0.0018

LYS 1185 THR 1186 0.0031

THR 1186 ILE 1187 0.0006

ILE 1187 SER 1188 0.0032

SER 1188 SER 1189 0.0007

SER 1189 ARG 1190 0.0019

ARG 1190 LYS 1191 0.0006

LYS 1191 ASP 1192 0.0030

ASP 1192 HIS 1193 0.0017

HIS 1193 SER 1194 0.0008

SER 1194 GLU 1195 0.0014

GLU 1195 SER 1196 0.0025

SER 1196 SER 1197 0.0207

SER 1197 PHE 1198 0.0035

PHE 1198 VAL 1199 0.0028

VAL 1199 VAL 1200 0.0029

VAL 1200 ALA 1201 0.0030

ALA 1201 ASN 1202 0.0026

ASN 1202 THR 1203 0.0020

THR 1203 ALA 1204 0.0031

ALA 1204 SER 1205 0.0007

SER 1205 VAL 1206 0.0030

VAL 1206 MET 1207 0.0025

MET 1207 PRO 1208 0.0031

PRO 1208 ASN 1209 0.0024

ASN 1209 GLY 1210 0.0033

GLY 1210 PHE 1211 0.0008

PHE 1211 GLN 1212 0.0010

GLN 1212 SER 1213 -0.0072

SER 1213 PRO 1214 0.0028

PRO 1214 HIS 1215 0.0017

HIS 1215 VAL 1216 0.0023

VAL 1216 ILE 1217 0.0027

ILE 1217 HIS 1218 0.0020

HIS 1218 PRO 1219 0.0025

PRO 1219 THR 1220 0.0009

THR 1220 THR 1221 0.0028

THR 1221 LEU 1222 0.0003

LEU 1222 ASP 1223 0.0029

ASP 1223 SER 1224 0.0015

SER 1224 ILE 1225 0.0013

ILE 1225 PHE 1226 0.0018

PHE 1226 GLN 1227 0.0012

GLN 1227 GLY 1228 0.0030

GLY 1228 ALA 1229 0.0116

ALA 1229 TYR 1230 0.0037

TYR 1230 THR 1231 0.0034

THR 1231 ALA 1232 0.0008

ALA 1232 LEU 1233 0.0037

LEU 1233 PRO 1234 0.0041

PRO 1234 GLY 1235 0.0003

GLY 1235 ALA 1236 0.0038

ALA 1236 GLY 1237 0.0037

GLY 1237 LEU 1238 0.0028

LEU 1238 ASP 1239 0.0017

ASP 1239 GLN 1240 0.0034

GLN 1240 ASN 1241 0.0036

ASN 1241 THR 1242 0.0042

THR 1242 ALA 1243 0.0034

ALA 1243 MET 1244 0.0029

MET 1244 ILE 1245 0.0358

ILE 1245 PRO 1246 0.0021

PRO 1246 ARG 1247 0.0002

ARG 1247 SER 1248 0.0018

SER 1248 ILE 1249 0.0025

ILE 1249 GLN 1250 0.0011

GLN 1250 GLU 1251 0.0022

GLU 1251 LEU 1252 0.0006

LEU 1252 TYR 1253 0.0024

TYR 1253 LEU 1254 0.0008

LEU 1254 SER 1255 0.0024

SER 1255 SER 1256 0.0022

SER 1256 ALA 1257 0.0011

ALA 1257 LEU 1258 0.0021

LEU 1258 THR 1259 0.0008

THR 1259 SER 1260 0.0022

SER 1260 ASP 1261 -0.0060

ASP 1261 VAL 1262 0.0033

VAL 1262 GLY 1263 0.0040

GLY 1263 GLN 1264 0.0024

GLN 1264 CYS 1265 0.0035

CYS 1265 LEU 1266 0.0000

LEU 1266 VAL 1267 0.0030

VAL 1267 SER 1268 0.0005

SER 1268 ASP 1269 0.0023

ASP 1269 THR 1270 0.0022

THR 1270 SER 1271 0.0011

SER 1271 LEU 1272 0.0029

LEU 1272 ILE 1273 0.0003

ILE 1273 ARG 1274 0.0037

ARG 1274 TYR 1275 0.0037

TYR 1275 ASP 1276 0.0030

ASP 1276 GLY 1277 0.0108

GLY 1277 GLN 1278 0.0029

GLN 1278 SER 1279 0.0032

SER 1279 PHE 1280 0.0028

PHE 1280 THR 1281 0.0031

THR 1281 VAL 1282 0.0020

VAL 1282 ASN 1283 0.0031

ASN 1283 VAL 1284 0.0005

VAL 1284 ASP 1285 0.0028

ASP 1285 VAL 1286 0.0005

VAL 1286 SER 1287 0.0020

SER 1287 SER 1288 0.0003

SER 1288 LYS 1289 0.0019

LYS 1289 ALA 1290 0.0024

ALA 1290 ASP 1291 0.0011

ASP 1291 SER 1292 0.0031

SER 1292 GLU 1293 -0.0166

GLU 1293 HIS 1294 0.0031

HIS 1294 THR 1295 0.0018

THR 1295 PRO 1296 0.0028

PRO 1296 VAL 1297 0.0029

VAL 1297 LEU 1298 0.0021

LEU 1298 GLU 1299 0.0010

GLU 1299 ILE 1300 0.0024

ILE 1300 LYS 1301 0.0007

LYS 1301 GLY 1302 0.0029

GLY 1302 LEU 1303 0.0014

LEU 1303 ARG 1304 0.0024

ARG 1304 ASN 1305 0.0020

ASN 1305 GLN 1306 0.0025

GLN 1306 SER 1307 0.0030

SER 1307 VAL 1308 0.0029

VAL 1308 GLY 1309 0.1730

GLY 1309 GLN 1310 0.0079

GLN 1310 MET 1311 0.0003

MET 1311 ALA 1312 0.0089

ALA 1312 PRO 1313 0.0089

PRO 1313 GLN 1314 0.0002

GLN 1314 PRO 1315 0.0084

PRO 1315 GLY 1316 0.0094

GLY 1316 ASP 1317 0.0045

ASP 1317 SER 1318 0.0043

SER 1318 SER 1319 0.0068

SER 1319 ASN 1320 0.0088

ASN 1320 ASN 1321 0.0034

ASN 1321 ASP 1322 0.0082

ASP 1322 LEU 1323 0.0082

LEU 1323 CYS 1324 0.0089

CYS 1324 PHE 1325 0.0402

PHE 1325 LYS 1326 0.0201

LYS 1326 LEU 1327 0.0242

LEU 1327 ASP 1328 0.0251

ASP 1328 TRP 1329 0.0257

TRP 1329 ALA 1330 0.0251

ALA 1330 PRO 1331 0.0250

PRO 1331 ASP 1332 0.0025

ASP 1332 ILE 1333 0.0244

ILE 1333 SER 1334 0.0141

SER 1334 SER 1335 0.0124

SER 1335 VAL 1336 0.0122

VAL 1336 LYS 1337 0.0221

LYS 1337 GLN 1338 0.0252

GLN 1338 GLU 1339 0.0028

GLU 1339 ARG 1340 0.0236

ARG 1340 LEU 1341 -0.0016

LEU 1341 LYS 1342 0.0236

LYS 1342 GLU 1343 0.0059

GLU 1343 LYS 1344 0.0285

LYS 1344 PHE 1345 0.0215

PHE 1345 GLY 1346 0.0268

GLY 1346 PHE 1347 0.0201

PHE 1347 PRO 1348 0.0128

PRO 1348 LEU 1349 0.0289

LEU 1349 ASP 1350 0.0211

ASP 1350 PRO 1351 0.0205

PRO 1351 THR 1352 0.0289

THR 1352 GLU 1353 0.0002

GLU 1353 ALA 1354 0.0290

ALA 1354 ASP 1355 0.0223

ASP 1355 ILE 1356 0.0163

ILE 1356 ILE 1357 0.0234

ILE 1357 MET 1358 0.0240

MET 1358 GLY 1359 0.0298

GLY 1359 LEU 1360 0.0020

LEU 1360 ARG 1361 0.0280

ARG 1361 GLN 1362 0.0203

GLN 1362 ALA 1363 0.0261

ALA 1363 CYS 1364 0.0041

CYS 1364 ILE 1365 0.0293

ILE 1365 HIS 1366 0.0265

HIS 1366 PHE 1367 0.0099

PHE 1367 ILE 1368 0.0201

ILE 1368 HIS 1369 0.0230

HIS 1369 ARG 1370 0.0301

ARG 1370 SER 1371 0.0018

SER 1371 LEU 1372 0.0281

LEU 1372 GLN 1373 0.0218

GLN 1373 SER 1374 0.0251

SER 1374 LEU 1375 0.0039

LEU 1375 THR 1376 0.0227

THR 1376 ALA 1377 0.0119

ALA 1377 PRO 1378 0.0183

PRO 1378 ASP 1379 0.0241

ASP 1379 ARG 1380 0.0293

ARG 1380 ASP 1381 0.0016

ASP 1381 GLN 1382 0.0298

GLN 1382 LEU 1383 0.0248

LEU 1383 ASP 1384 0.0195

ASP 1384 TRP 1385 0.0288

TRP 1385 HIS 1386 0.0149

HIS 1386 GLN 1387 0.0174

GLN 1387 LYS 1388 0.0289

LYS 1388 ARG 1389 0.0250

ARG 1389 PHE 1390 0.0101

PHE 1390 TYR 1391 0.0295

TYR 1391 ASP 1392 0.0302

ASP 1392 TRP 1393 0.0190

TRP 1393 MET 1394 0.0182

MET 1394 VAL 1395 0.0303

VAL 1395 LEU 1396 0.0295

LEU 1396 GLN 1397 0.0121

GLN 1397 ILE 1398 0.0251

ILE 1398 GLN 1399 0.0298

GLN 1399 LEU 1400 0.0254

LEU 1400 ALA 1401 0.0130

ALA 1401 GLU 1402 0.0299

GLU 1402 GLU 1403 0.0304

GLU 1403 ASP 1404 0.0150

ASP 1404 ARG 1405 0.0163

ARG 1405 LEU 1406 0.0302

LEU 1406 ALA 1407 0.0015

ALA 1407 PRO 1408 0.0118

PRO 1408 ASN 1409 0.0295

ASN 1409 SER 1410 0.0102

SER 1410 SER 1411 0.0299

SER 1411 ALA 1412 0.0113

ALA 1412 TRP 1413 0.0222

TRP 1413 LEU 1414 0.0213

LEU 1414 GLN 1415 0.0101

GLN 1415 CYS 1416 0.0267

CYS 1416 SER 1417 0.0257

SER 1417 SER 1418 0.0234

SER 1418 SER 1419 0.0109

SER 1419 ASP 1420 0.0301

ASP 1420 GLU 1421 0.0018

GLU 1421 GLN 1422 0.0299

GLN 1422 LYS 1423 0.0140

LYS 1423 LEU 1424 0.0218

LEU 1424 LEU 1425 0.0116

LEU 1425 GLU 1426 0.0208

GLU 1426 ASN 1427 0.0251

ASN 1427 VAL 1428 0.0071

VAL 1428 ARG 1429 0.0254

ARG 1429 ALA 1430 0.0131

ALA 1430 SER 1431 0.0300

SER 1431 SER 1432 0.0053

SER 1432 VAL 1433 0.0054

VAL 1433 ASN 1434 0.0273

ASN 1434 GLY 1435 0.0197

GLY 1435 GLN 1436 0.0266

GLN 1436 MET 1437 0.0038

MET 1437 VAL 1438 0.0287

VAL 1438 VAL 1439 0.0230

VAL 1439 HIS 1440 0.0153

HIS 1440 VAL 1441 0.0128

VAL 1441 GLY 1442 0.0226

GLY 1442 LYS 1443 0.0279

LYS 1443 SER 1444 0.0020

SER 1444 MET 1445 0.0265

MET 1445 LEU 1446 0.0283

LEU 1446 ALA 1447 0.0240

ALA 1447 ILE 1448 0.0227

ILE 1448 LEU 1449 0.0276

LEU 1449 ARG 1450 0.0272

ARG 1450 HIS 1451 0.0220

HIS 1451 GLU 1452 0.0203

GLU 1452 ILE 1453 0.0334

ILE 1453 ALA 1454 0.0234

ALA 1454 PRO 1455 0.0191

PRO 1455 LEU 1456 0.0276

LEU 1456 GLU 1457 0.0294

GLU 1457 LEU 1458 0.0056

LEU 1458 MET 1459 0.0287

MET 1459 LEU 1460 0.0268

LEU 1460 GLN 1461 0.0188

GLN 1461 ASP 1462 0.0147

ASP 1462 LYS 1463 0.0244

LYS 1463 LEU 1464 0.0234

LEU 1464 LEU 1465 0.0147

LEU 1465 TYR 1466 0.0299

TYR 1466 ARG 1467 0.0006

ARG 1467 TYR 1468 0.0295

TYR 1468 TYR 1469 0.0247

TYR 1469 THR 1470 0.0154

THR 1470 ASP 1471 0.0060

ASP 1471 ALA 1472 0.0287

ALA 1472 ILE 1473 0.0193

ILE 1473 LYS 1474 0.0262

LYS 1474 TRP 1475 0.0155

TRP 1475 ASP 1476 0.0207

ASP 1476 ARG 1477 0.0276

ARG 1477 SER 1478 0.0023

SER 1478 TYR 1479 0.0273

TYR 1479 GLN 1480 0.0143

GLN 1480 GLN 1481 0.0250

GLN 1481 ILE 1482 0.0054

ILE 1482 ASP 1483 0.0251

ASP 1483 GLN 1484 0.0251

GLN 1484 LEU 1485 0.0099

LEU 1485 VAL 1486 0.0186

VAL 1486 LYS 1487 0.0174

LYS 1487 LEU 1488 0.0267

LEU 1488 HIS 1489 0.0007

HIS 1489 ALA 1490 0.0268

ALA 1490 HIS 1491 0.0200

HIS 1491 LYS 1492 0.0163

LYS 1492 CYS 1493 0.0087

CYS 1493 PRO 1494 0.0261

PRO 1494 THR 1495 0.0009

THR 1495 ALA 1496 0.0271

ALA 1496 LYS 1497 0.0142

LYS 1497 ILE 1498 0.0200

ILE 1498 ILE 1499 0.0245

ILE 1499 GLU 1500 0.0180

GLU 1500 ILE 1501 0.0223

ILE 1501 GLY 1502 0.0254

GLY 1502 ALA 1503 0.0164

ALA 1503 GLY 1504 0.0279

GLY 1504 THR 1505 0.0112

THR 1505 GLY 1506 0.0272

GLY 1506 GLY 1507 0.0081

GLY 1507 CYS 1508 0.0270

CYS 1508 THR 1509 0.0211

THR 1509 ARG 1510 0.0082

ARG 1510 ALA 1511 0.0218

ALA 1511 VAL 1512 0.0092

VAL 1512 LEU 1513 0.0276

LEU 1513 ASP 1514 0.0014

ASP 1514 ALA 1515 0.0276

ALA 1515 LEU 1516 0.0085

LEU 1516 SER 1517 0.0293

SER 1517 ASN 1518 0.0174

ASN 1518 GLN 1519 0.0219

GLN 1519 GLY 1520 0.0093

GLY 1520 ILE 1521 0.0129

ILE 1521 ALA 1522 0.0182

ALA 1522 ARG 1523 0.0267

ARG 1523 CYS 1524 0.0058

CYS 1524 ALA 1525 0.0031

ALA 1525 GLN 1526 0.0261

GLN 1526 TYR 1527 0.0219

TYR 1527 ASP 1528 0.0175

ASP 1528 PHE 1529 0.0206

PHE 1529 THR 1530 0.0204

THR 1530 ASP 1531 0.0271

ASP 1531 VAL 1532 0.0170

VAL 1532 SER 1533 0.0249

SER 1533 SER 1534 0.0276

SER 1534 GLY 1535 0.0149

GLY 1535 PHE 1536 0.0124

PHE 1536 PHE 1537 0.0226

PHE 1537 GLU 1538 0.0261

GLU 1538 ALA 1539 0.0021

ALA 1539 ALA 1540 0.0277

ALA 1540 GLN 1541 0.0226

GLN 1541 GLN 1542 0.0129

GLN 1542 LYS 1543 0.0148

LYS 1543 PHE 1544 0.0243

PHE 1544 ALA 1545 0.0243

ALA 1545 ALA 1546 0.0198

ALA 1546 PHE 1547 0.0165

PHE 1547 ASP 1548 0.0074

ASP 1548 ASP 1549 0.0349

ASP 1549 VAL 1550 0.0276

VAL 1550 ILE 1551 0.0274

ILE 1551 ARG 1552 0.0054

ARG 1552 PHE 1553 0.0277

PHE 1553 GLN 1554 0.0126

GLN 1554 LYS 1555 0.0267

LYS 1555 LEU 1556 0.0278

LEU 1556 ASP 1557 0.0267

ASP 1557 ILE 1558 0.0263

ILE 1558 GLU 1559 0.0205

GLU 1559 LYS 1560 0.0085

LYS 1560 ASP 1561 0.0216

ASP 1561 ILE 1562 0.0219

ILE 1562 GLU 1563 0.0112

GLU 1563 MET 1564 0.0233

MET 1564 GLN 1565 0.0069

GLN 1565 GLY 1566 0.0280

GLY 1566 PHE 1567 0.0153

PHE 1567 GLU 1568 0.0266

GLU 1568 CYS 1569 0.0277

CYS 1569 GLY 1570 0.0184

GLY 1570 SER 1571 0.0252

SER 1571 TYR 1572 0.0024

TYR 1572 ASP 1573 0.0111

ASP 1573 LEU 1574 0.0175

LEU 1574 VAL 1575 0.0271

VAL 1575 ILE 1576 0.0126

ILE 1576 ALA 1577 0.0281

ALA 1577 SER 1578 0.0102

SER 1578 GLN 1579 0.0283

GLN 1579 VAL 1580 0.0007

VAL 1580 LEU 1581 0.0259

LEU 1581 HIS 1582 0.0245

HIS 1582 ALA 1583 0.0199

ALA 1583 THR 1584 0.0079

THR 1584 GLY 1585 0.0190

GLY 1585 LYS 1586 0.0284

LYS 1586 MET 1587 0.0168

MET 1587 GLU 1588 0.0198

GLU 1588 HIS 1589 0.0139

HIS 1589 THR 1590 0.0168

THR 1590 MET 1591 0.0240

MET 1591 ALA 1592 0.0058

ALA 1592 ASN 1593 0.0278

ASN 1593 VAL 1594 0.0056

VAL 1594 ARG 1595 0.0275

ARG 1595 LYS 1596 0.0089

LYS 1596 LEU 1597 0.0179

LEU 1597 LEU 1598 0.0202

LEU 1598 LYS 1599 0.0267

LYS 1599 PRO 1600 0.0280

PRO 1600 GLY 1601 0.0006

GLY 1601 GLY 1602 0.0278

GLY 1602 LYS 1603 0.0103

LYS 1603 LEU 1604 0.0283

LEU 1604 LEU 1605 0.0080

LEU 1605 LEU 1606 0.0281

LEU 1606 VAL 1607 0.0140

VAL 1607 GLU 1608 0.0280

GLU 1608 THR 1609 0.0221

THR 1609 THR 1610 0.0280

THR 1610 ARG 1611 0.0174

ARG 1611 ASP 1612 0.0283

ASP 1612 GLU 1613 0.0052

GLU 1613 MET 1614 0.0298

MET 1614 ASP 1615 0.0295

ASP 1615 LEU 1616 0.0111

LEU 1616 GLN 1617 0.0206

GLN 1617 LEU 1618 0.0273

LEU 1618 VAL 1619 0.0288

VAL 1619 PHE 1620 0.0068

PHE 1620 GLY 1621 0.0272

GLY 1621 LEU 1622 0.0279

LEU 1622 LEU 1623 0.0155

LEU 1623 PRO 1624 0.0063

PRO 1624 GLY 1625 0.0297

GLY 1625 TRP 1626 0.0126

TRP 1626 TRP 1627 0.0206

TRP 1627 LEU 1628 0.0086

LEU 1628 SER 1629 0.0254

SER 1629 SER 1630 0.0170

SER 1630 GLU 1631 0.0217

GLU 1631 GLU 1632 0.0227

GLU 1632 GLU 1633 0.0087

GLU 1633 ARG 1634 0.0296

ARG 1634 GLN 1635 0.0283

GLN 1635 MET 1636 0.0020

MET 1636 SER 1637 0.0283

SER 1637 PRO 1638 0.0212

PRO 1638 SER 1639 0.0191

SER 1639 LEU 1640 0.0293

LEU 1640 SER 1641 0.0134

SER 1641 THR 1642 0.0291

THR 1642 ASN 1643 0.0261

ASN 1643 SER 1644 0.0096

SER 1644 TRP 1645 0.0247

TRP 1645 GLU 1646 0.0289

GLU 1646 LYS 1647 0.0122

LYS 1647 VAL 1648 0.0203

VAL 1648 LEU 1649 0.0285

LEU 1649 LYS 1650 0.0270

LYS 1650 LYS 1651 0.0093

LYS 1651 THR 1652 0.0274

THR 1652 GLY 1653 0.0292

GLY 1653 PHE 1654 0.0021

PHE 1654 ASP 1655 0.0197

ASP 1655 GLY 1656 0.0168

GLY 1656 LEU 1657 0.0075

LEU 1657 ASP 1658 0.0247

ASP 1658 ILE 1659 0.0112

ILE 1659 GLU 1660 0.0244

GLU 1660 LEU 1661 0.0121

LEU 1661 ARG 1662 0.0246

ARG 1662 ASP 1663 0.0246

ASP 1663 CYS 1664 0.0095

CYS 1664 ASP 1665 0.0256

ASP 1665 SER 1666 0.0289

SER 1666 ASP 1667 0.0185

ASP 1667 GLU 1668 0.0272

GLU 1668 PHE 1669 0.0289

PHE 1669 TYR 1670 0.0155

TYR 1670 SER 1671 0.0080

SER 1671 PHE 1672 0.0228

PHE 1672 SER 1673 0.0266

SER 1673 VAL 1674 0.0269

VAL 1674 MET 1675 0.0155

MET 1675 MET 1676 0.0225

MET 1676 ALA 1677 0.0011

ALA 1677 THR 1678 0.0150

THR 1678 ALA 1679 0.0001

ALA 1679 SER 1680 0.0213

SER 1680 SER 1681 0.0207

SER 1681 THR 1682 0.0161

THR 1682 ILE 1683 0.0181

ILE 1683 ALA 1684 0.0096

ALA 1684 SER 1685 0.0221

SER 1685 SER 1686 0.0231

SER 1686 SER 1687 0.0225

SER 1687 MET 1688 0.0124

MET 1688 ALA 1689 0.0169

ALA 1689 PHE 1690 0.0005

PHE 1690 ALA 1691 0.0106

ALA 1691 ILE 1692 0.0003

ILE 1692 VAL 1693 0.0133

VAL 1693 TYR 1694 0.0015

TYR 1694 GLY 1695 0.0169

GLY 1695 GLU 1696 0.0139

GLU 1696 VAL 1697 0.0165

VAL 1697 PRO 1698 0.0169

PRO 1698 LEU 1699 0.0225

LEU 1699 PRO 1700 0.0181

PRO 1700 ASP 1701 0.0132

ASP 1701 GLN 1702 0.0217

GLN 1702 PHE 1703 0.0219

PHE 1703 LEU 1704 0.0065

LEU 1704 ASP 1705 0.0201

ASP 1705 ASP 1706 0.0213

ASP 1706 MET 1707 0.0173

MET 1707 LYS 1708 0.0080

LYS 1708 THR 1709 0.0213

THR 1709 ALA 1710 0.0222

ALA 1710 ILE 1711 0.0105

ILE 1711 SER 1712 0.0146

SER 1712 SER 1713 0.0221

SER 1713 SER 1714 0.0200

SER 1714 ALA 1715 0.0118

ALA 1715 VAL 1716 0.0095

VAL 1716 SER 1717 0.0199

SER 1717 ASP 1718 0.0068

ASP 1718 PRO 1719 0.0180

PRO 1719 VAL 1720 0.0220

VAL 1720 VAL 1721 0.0022

VAL 1721 GLY 1722 0.0216

GLY 1722 HIS 1723 0.0140

HIS 1723 LEU 1724 0.0207

LEU 1724 ASP 1725 0.0141

ASP 1725 SER 1726 0.0156

SER 1726 ILE 1727 0.0179

ILE 1727 ASP 1728 0.0011

ASP 1728 ALA 1729 0.0228

ALA 1729 THR 1730 0.0010

THR 1730 GLY 1731 0.0178

GLY 1731 LYS 1732 0.0079

LYS 1732 PHE 1733 0.0158

PHE 1733 CYS 1734 0.0039

CYS 1734 ILE 1735 0.0034

ILE 1735 PHE 1736 0.0136

PHE 1736 ILE 1737 0.0023

ILE 1737 GLU 1738 0.0132

GLU 1738 ASP 1739 0.0033

ASP 1739 PRO 1740 0.0138

PRO 1740 GLU 1741 0.0072

GLU 1741 THR 1742 0.0109

THR 1742 ASP 1743 0.0199

ASP 1743 ILE 1744 0.0081

ILE 1744 LEU 1745 0.0210

LEU 1745 SER 1746 0.0049

SER 1746 SER 1747 0.0227

SER 1747 PRO 1748 0.0069

PRO 1748 ASP 1749 0.0224

ASP 1749 GLU 1750 0.0047

GLU 1750 LYS 1751 0.0208

LYS 1751 SER 1752 0.0209

SER 1752 TYR 1753 0.0193

TYR 1753 ALA 1754 0.0053

ALA 1754 SER 1755 0.0227

SER 1755 ILE 1756 0.0226

ILE 1756 GLN 1757 0.0194

GLN 1757 LYS 1758 0.0155

LYS 1758 LEU 1759 0.0205

LEU 1759 VAL 1760 0.0215

VAL 1760 THR 1761 0.0064

THR 1761 ARG 1762 0.0197

ARG 1762 CYS 1763 0.0204

CYS 1763 LYS 1764 0.0144

LYS 1764 GLY 1765 0.0079

GLY 1765 LEU 1766 0.0003

LEU 1766 ILE 1767 0.0080

ILE 1767 TRP 1768 0.0086

TRP 1768 VAL 1769 0.0071

VAL 1769 SER 1770 0.0051

SER 1770 ARG 1771 0.0035

ARG 1771 GLY 1772 0.0164

GLY 1772 GLY 1773 0.0151

GLY 1773 ALA 1774 0.0179

ALA 1774 MET 1775 0.0161

MET 1775 HIS 1776 0.0018

HIS 1776 GLY 1777 0.0210

GLY 1777 THR 1778 0.0102

THR 1778 ARG 1779 0.0175

ARG 1779 PRO 1780 0.0181

PRO 1780 ASN 1781 0.0169

ASN 1781 SER 1782 0.0153

SER 1782 SER 1783 0.0175

SER 1783 LEU 1784 0.0173

LEU 1784 LYS 1785 0.0101

LYS 1785 THR 1786 0.0208

THR 1786 GLY 1787 0.0210

GLY 1787 LEU 1788 0.0138

LEU 1788 LEU 1789 0.0071

LEU 1789 ARG 1790 0.0225

ARG 1790 THR 1791 0.0178

THR 1791 LEU 1792 0.0168

LEU 1792 ARG 1793 0.0194

ARG 1793 LEU 1794 0.0190

LEU 1794 GLU 1795 0.0208

GLU 1795 TYR 1796 0.0187

TYR 1796 THR 1797 0.0207

THR 1797 GLU 1798 0.0172

GLU 1798 LYS 1799 0.0074

LYS 1799 ARG 1800 0.0116

ARG 1800 PHE 1801 0.0043

PHE 1801 ILE 1802 0.0105

ILE 1802 SER 1803 0.0006

SER 1803 LEU 1804 0.0149

LEU 1804 ASP 1805 0.0029

ASP 1805 LEU 1806 0.0172

LEU 1806 ASP 1807 0.0048

ASP 1807 SER 1808 0.0106

SER 1808 ALA 1809 0.0125

ALA 1809 ARG 1810 0.0182

ARG 1810 PRO 1811 0.0227

PRO 1811 GLN 1812 0.0138

GLN 1812 TRP 1813 0.0143

TRP 1813 ASN 1814 0.0227

ASN 1814 HIS 1815 0.0113

HIS 1815 ASP 1816 0.0227

ASP 1816 SER 1817 0.0211

SER 1817 ILE 1818 0.0091

ILE 1818 THR 1819 0.0216

THR 1819 THR 1820 0.0227

THR 1820 ILE 1821 0.0204

ILE 1821 ASN 1822 0.0125

ASN 1822 GLU 1823 0.0238

GLU 1823 VAL 1824 0.0231

VAL 1824 LEU 1825 0.0129

LEU 1825 CYS 1826 0.0188

CYS 1826 GLY 1827 0.0237

GLY 1827 ALA 1828 0.0200

ALA 1828 LEU 1829 0.0114

LEU 1829 ALA 1830 0.0229

ALA 1830 GLN 1831 0.0214

GLN 1831 ASN 1832 0.0003

ASN 1832 ALA 1833 0.0187

ALA 1833 ASP 1834 0.0232

ASP 1834 SER 1835 0.0010

SER 1835 SER 1836 0.0238

SER 1836 ILE 1837 -0.0016

ILE 1837 LYS 1838 0.0202

LYS 1838 ASP 1839 0.0011

ASP 1839 SER 1840 0.0218

SER 1840 GLU 1841 0.0002

GLU 1841 PHE 1842 0.0158

PHE 1842 ALA 1843 0.0009

ALA 1843 GLU 1844 0.0177

GLU 1844 GLN 1845 0.0063

GLN 1845 ASP 1846 0.0178

ASP 1846 GLY 1847 0.0073

GLY 1847 GLN 1848 0.0151

GLN 1848 LEU 1849 0.0107

LEU 1849 PHE 1850 0.0231

PHE 1850 VAL 1851 0.0123

VAL 1851 PRO 1852 0.0227

PRO 1852 ARG 1853 0.0689

ARG 1853 ILE 1854 0.0196

ILE 1854 SER 1855 0.0186

SER 1855 CYS 1856 0.0188

CYS 1856 ASP 1857 0.0014

ASP 1857 ILE 1858 0.0197

ILE 1858 ALA 1859 0.0006

ALA 1859 ARG 1860 0.0196

ARG 1860 ASN 1861 0.0062

ASN 1861 GLU 1862 0.0156

GLU 1862 ASP 1863 0.0079

ASP 1863 LEU 1864 0.0126

LEU 1864 SER 1865 0.0143

SER 1865 SER 1866 0.0062

SER 1866 ASP 1867 0.0197

ASP 1867 SER 1868 0.0074

SER 1868 ASN 1869 -0.1230

ASN 1869 SER 1870 0.0011

SER 1870 PRO 1871 0.0002

PRO 1871 ALA 1872 0.0009

ALA 1872 GLN 1873 0.0013

GLN 1873 MET 1874 0.0001

MET 1874 GLU 1875 0.0016

GLU 1875 PRO 1876 0.0009

PRO 1876 PHE 1877 0.0018

PHE 1877 HIS 1878 0.0017

HIS 1878 GLN 1879 0.0007

GLN 1879 PRO 1880 0.0018

PRO 1880 GLY 1881 0.0004

GLY 1881 LYS 1882 0.0018

LYS 1882 LEU 1883 0.0019

LEU 1883 LEU 1884 0.0017

LEU 1884 GLN 1885 0.0114

GLN 1885 MET 1886 0.0013

MET 1886 GLY 1887 0.0009

GLY 1887 ILE 1888 0.0011

ILE 1888 LYS 1889 0.0000

LYS 1889 THR 1890 0.0013

THR 1890 PRO 1891 0.0006

PRO 1891 GLY 1892 0.0014

GLY 1892 LEU 1893 0.0013

LEU 1893 ILE 1894 0.0006

ILE 1894 ASP 1895 0.0009

ASP 1895 THR 1896 0.0012

THR 1896 LEU 1897 0.0004

LEU 1897 GLN 1898 0.0012

GLN 1898 PHE 1899 0.0015

PHE 1899 SER 1900 0.0010

SER 1900 LYS 1901 0.0182

LYS 1901 THR 1902 0.0012

THR 1902 ASP 1903 0.0015

ASP 1903 ALA 1904 0.0002

ALA 1904 THR 1905 0.0014

THR 1905 ASP 1906 0.0009

ASP 1906 ASN 1907 0.0011

ASN 1907 LEU 1908 0.0003

LEU 1908 PRO 1909 0.0012

PRO 1909 ASN 1910 0.0005

ASN 1910 ASP 1911 0.0010

ASP 1911 TYR 1912 0.0014

TYR 1912 ILE 1913 0.0011

ILE 1913 GLU 1914 0.0011

GLU 1914 ILE 1915 0.0011

ILE 1915 GLU 1916 0.0014

GLU 1916 PRO 1917 0.0109

PRO 1917 LYS 1918 0.0013

LYS 1918 ALA 1919 0.0015

ALA 1919 PHE 1920 0.0013

PHE 1920 GLY 1921 0.0013

GLY 1921 LEU 1922 0.0009

LEU 1922 ASN 1923 0.0014

ASN 1923 PHE 1924 0.0012

PHE 1924 ARG 1925 0.0012

ARG 1925 ASP 1926 0.0011

ASP 1926 VAL 1927 0.0012

VAL 1927 MET 1928 0.0015

MET 1928 VAL 1929 0.0012

VAL 1929 ALA 1930 0.0010

ALA 1930 MET 1931 0.0015

MET 1931 GLY 1932 0.0013

GLY 1932 GLN 1933 0.0246

GLN 1933 LEU 1934 0.0012

LEU 1934 GLU 1935 0.0016

GLU 1935 GLU 1936 0.0014

GLU 1936 SER 1937 0.0014

SER 1937 ILE 1938 0.0007

ILE 1938 MET 1939 0.0015

MET 1939 GLY 1940 0.0008

GLY 1940 PHE 1941 0.0003

PHE 1941 GLU 1942 0.0008

GLU 1942 CYS 1943 0.0018

CYS 1943 ALA 1944 0.0010

ALA 1944 GLY 1945 0.0016

GLY 1945 VAL 1946 0.0015

VAL 1946 VAL 1947 0.0016

VAL 1947 ARG 1948 0.0008

ARG 1948 ARG 1949 -0.0104

ARG 1949 VAL 1950 0.0009

VAL 1950 GLY 1951 0.0013

GLY 1951 PRO 1952 0.0012

PRO 1952 SER 1953 0.0011

SER 1953 SER 1954 0.0012

SER 1954 ALA 1955 0.0012

ALA 1955 GLY 1956 0.0007

GLY 1956 HIS 1957 0.0014

HIS 1957 ASN 1958 0.0012

ASN 1958 ILE 1959 0.0004

ILE 1959 LYS 1960 0.0012

LYS 1960 VAL 1961 0.0004

VAL 1961 GLY 1962 0.0011

GLY 1962 ASP 1963 0.0007

ASP 1963 ARG 1964 0.0013

ARG 1964 VAL 1965 0.0004

VAL 1965 CYS 1966 0.0011

CYS 1966 ALA 1967 0.0011

ALA 1967 LEU 1968 0.0011

LEU 1968 LEU 1969 0.0000

LEU 1969 GLY 1970 0.0009

GLY 1970 GLY 1971 0.0010

GLY 1971 GLN 1972 0.0008

GLN 1972 TRP 1973 0.0013

TRP 1973 THR 1974 0.0014

THR 1974 ASN 1975 0.0013

ASN 1975 THR 1976 0.0013

THR 1976 VAL 1977 0.0012

VAL 1977 ARG 1978 0.0013

ARG 1978 VAL 1979 0.0008

VAL 1979 HIS 1980 0.0008

HIS 1980 TRP 1981 -0.0017

TRP 1981 HIS 1982 0.0008

HIS 1982 SER 1983 0.0011

SER 1983 VAL 1984 0.0010

VAL 1984 ALA 1985 0.0004

ALA 1985 PRO 1986 0.0011

PRO 1986 ILE 1987 0.0013

ILE 1987 PRO 1988 0.0004

PRO 1988 GLN 1989 0.0011

GLN 1989 ALA 1990 0.0012

ALA 1990 MET 1991 0.0008

MET 1991 ASP 1992 0.0001

ASP 1992 TRP 1993 0.0003

TRP 1993 GLU 1994 0.0011

GLU 1994 THR 1995 0.0003

THR 1995 ALA 1996 0.0014

ALA 1996 ALA 1997 -0.0010

ALA 1997 SER 1998 0.0007

SER 1998 ILE 1999 0.0004

ILE 1999 PRO 2000 0.0010

PRO 2000 ILE 2001 0.0010

ILE 2001 VAL 2002 0.0008

VAL 2002 PHE 2003 0.0001

PHE 2003 VAL 2004 0.0012

VAL 2004 THR 2005 0.0009

THR 2005 ALA 2006 0.0006

ALA 2006 TYR 2007 0.0007

TYR 2007 ILE 2008 0.0010

ILE 2008 SER 2009 0.0012

SER 2009 LEU 2010 0.0002

LEU 2010 VAL 2011 0.0009

VAL 2011 LYS 2012 0.0009

LYS 2012 ILE 2013 0.0056

ILE 2013 ALA 2014 0.0011

ALA 2014 ARG 2015 0.0006

ARG 2015 MET 2016 0.0012

MET 2016 GLN 2017 0.0003

GLN 2017 ALA 2018 0.0013

ALA 2018 GLY 2019 0.0015

GLY 2019 GLU 2020 0.0009

GLU 2020 THR 2021 0.0004

THR 2021 VAL 2022 0.0001

VAL 2022 LEU 2023 0.0003

LEU 2023 ILE 2024 0.0006

ILE 2024 HIS 2025 0.0004

HIS 2025 ALA 2026 0.0001

ALA 2026 ALA 2027 0.0010

ALA 2027 SER 2028 0.0006

SER 2028 GLY 2029 0.0108

GLY 2029 GLY 2030 0.0010

GLY 2030 VAL 2031 0.0007

VAL 2031 GLY 2032 0.0007

GLY 2032 GLN 2033 0.0009

GLN 2033 ALA 2034 0.0008

ALA 2034 ALA 2035 0.0006

ALA 2035 ILE 2036 0.0010

ILE 2036 ILE 2037 0.0010

ILE 2037 LEU 2038 0.0007

LEU 2038 ALA 2039 0.0008

ALA 2039 LYS 2040 0.0008

LYS 2040 HIS 2041 0.0010

HIS 2041 VAL 2042 0.0008

VAL 2042 GLY 2043 0.0008

GLY 2043 ALA 2044 0.0010

ALA 2044 GLU 2045 -0.0097

GLU 2045 ILE 2046 -0.0002

ILE 2046 PHE 2047 0.0010

PHE 2047 ALA 2048 0.0000

ALA 2048 THR 2049 0.0002

THR 2049 VAL 2050 0.0005

VAL 2050 GLY 2051 0.0001

GLY 2051 THR 2052 0.0014

THR 2052 ASP 2053 0.0012

ASP 2053 GLU 2054 0.0012

GLU 2054 LYS 2055 0.0008

LYS 2055 ARG 2056 0.0004

ARG 2056 ASP 2057 0.0015

ASP 2057 LEU 2058 0.0016

LEU 2058 LEU 2059 0.0002

LEU 2059 ILE 2060 0.0012

ILE 2060 LYS 2061 -0.0011

LYS 2061 GLU 2062 0.0014

GLU 2062 TYR 2063 0.0004

TYR 2063 LYS 2064 0.0013

LYS 2064 ILE 2065 0.0015

ILE 2065 PRO 2066 0.0013

PRO 2066 ASP 2067 0.0006

ASP 2067 ASP 2068 0.0010

ASP 2068 HIS 2069 0.0013

HIS 2069 ILE 2070 0.0001

ILE 2070 PHE 2071 0.0011

PHE 2071 SER 2072 0.0004

SER 2072 SER 2073 0.0014

SER 2073 ARG 2074 0.0007

ARG 2074 ASN 2075 0.0009

ASN 2075 ALA 2076 0.0003

ALA 2076 LEU 2077 0.0144

LEU 2077 PHE 2078 0.0014

PHE 2078 ALA 2079 0.0007

ALA 2079 LYS 2080 0.0012

LYS 2080 SER 2081 0.0012

SER 2081 ILE 2082 0.0012

ILE 2082 ARG 2083 0.0005

ARG 2083 GLN 2084 0.0015

GLN 2084 ARG 2085 0.0014

ARG 2085 THR 2086 0.0008

THR 2086 ASN 2087 0.0007

ASN 2087 GLY 2088 0.0013

GLY 2088 LYS 2089 0.0013

LYS 2089 GLY 2090 0.0002

GLY 2090 VAL 2091 0.0012

VAL 2091 ASP 2092 0.0011

ASP 2092 VAL 2093 -0.0139

VAL 2093 VAL 2094 0.0003

VAL 2094 LEU 2095 0.0003

LEU 2095 ASN 2096 0.0009

ASN 2096 CYS 2097 -0.0001

CYS 2097 LEU 2098 0.0013

LEU 2098 ALA 2099 0.0013

ALA 2099 GLY 2100 0.0011

GLY 2100 GLY 2101 0.0010

GLY 2101 LEU 2102 0.0015

LEU 2102 LEU 2103 0.0012

LEU 2103 GLN 2104 0.0005

GLN 2104 GLU 2105 0.0013

GLU 2105 SER 2106 0.0014

SER 2106 PHE 2107 0.0007

PHE 2107 ASP 2108 0.0007

ASP 2108 CYS 2109 -0.0053

CYS 2109 LEU 2110 0.0014

LEU 2110 ALA 2111 0.0001

ALA 2111 ASP 2112 0.0010

ASP 2112 PHE 2113 0.0013

PHE 2113 GLY 2114 0.0004

GLY 2114 ARG 2115 0.0002

ARG 2115 PHE 2116 0.0004

PHE 2116 ILE 2117 0.0004

ILE 2117 GLU 2118 0.0005

GLU 2118 ILE 2119 0.0003

ILE 2119 GLY 2120 0.0012

GLY 2120 LYS 2121 0.0011

LYS 2121 ARG 2122 0.0014

ARG 2122 ASP 2123 0.0003

ASP 2123 ILE 2124 0.0014

ILE 2124 GLU 2125 -0.0067

GLU 2125 LEU 2126 0.0013

LEU 2126 ASN 2127 0.0005

ASN 2127 HIS 2128 0.0010

HIS 2128 CYS 2129 0.0001

CYS 2129 LEU 2130 0.0007

LEU 2130 ASN 2131 0.0002

ASN 2131 MET 2132 0.0008

MET 2132 GLY 2133 0.0006

GLY 2133 MET 2134 0.0013

MET 2134 PHE 2135 0.0013

PHE 2135 ALA 2136 -0.0000

ALA 2136 ARG 2137 0.0013

ARG 2137 SER 2138 0.0011

SER 2138 ALA 2139 0.0002

ALA 2139 THR 2140 0.0004

THR 2140 PHE 2141 0.0159

PHE 2141 THR 2142 0.0006

THR 2142 ALA 2143 0.0002

ALA 2143 VAL 2144 0.0012

VAL 2144 ASP 2145 0.0000

ASP 2145 LEU 2146 0.0011

LEU 2146 ILE 2147 0.0001

ILE 2147 ALA 2148 0.0009

ALA 2148 ILE 2149 0.0006

ILE 2149 GLY 2150 0.0006

GLY 2150 ARG 2151 0.0008

ARG 2151 ASP 2152 0.0007

ASP 2152 ARG 2153 0.0007

ARG 2153 SER 2154 0.0010

SER 2154 TYR 2155 0.0006

TYR 2155 MET 2156 0.0008

MET 2156 PHE 2157 0.0006

PHE 2157 ALA 2158 0.0010

ALA 2158 GLU 2159 0.0005

GLU 2159 ALA 2160 0.0010

ALA 2160 LEU 2161 0.0008

LEU 2161 PRO 2162 0.0008

PRO 2162 LYS 2163 0.0005

LYS 2163 ILE 2164 0.0011

ILE 2164 MET 2165 0.0012

MET 2165 THR 2166 0.0001

THR 2166 LEU 2167 0.0010

LEU 2167 LEU 2168 0.0005

LEU 2168 GLN 2169 0.0009

GLN 2169 GLU 2170 0.0001

GLU 2170 LYS 2171 0.0010

LYS 2171 ALA 2172 0.0010

ALA 2172 ILE 2173 0.0142

ILE 2173 ARG 2174 0.0008

ARG 2174 PRO 2175 0.0001

PRO 2175 VAL 2176 0.0008

VAL 2176 THR 2177 0.0008

THR 2177 PRO 2178 0.0004

PRO 2178 ILE 2179 0.0008

ILE 2179 SER 2180 0.0004

SER 2180 ILE 2181 0.0007

ILE 2181 TYR 2182 -0.0000

TYR 2182 LYS 2183 0.0008

LYS 2183 ILE 2184 0.0006

ILE 2184 GLY 2185 0.0004

GLY 2185 ASP 2186 0.0010

ASP 2186 ILE 2187 0.0010

ILE 2187 GLU 2188 0.0007

GLU 2188 THR 2189 0.0232

THR 2189 ALA 2190 0.0003

ALA 2190 PHE 2191 0.0009

PHE 2191 ARG 2192 0.0009

ARG 2192 LEU 2193 0.0001

LEU 2193 MET 2194 0.0009

MET 2194 GLN 2195 0.0006

GLN 2195 ALA 2196 0.0008

ALA 2196 GLY 2197 0.0001

GLY 2197 LYS 2198 0.0010

LYS 2198 HIS 2199 0.0007

HIS 2199 MET 2200 0.0001

MET 2200 GLY 2201 0.0010

GLY 2201 LYS 2202 0.0003

LYS 2202 ILE 2203 0.0001

ILE 2203 VAL 2204 0.0012

VAL 2204 ILE 2205 0.0476

ILE 2205 THR 2206 0.0011

THR 2206 ALA 2207 0.0007

ALA 2207 PRO 2208 0.0010

PRO 2208 GLU 2209 0.0007

GLU 2209 ASP 2210 0.0010

ASP 2210 ALA 2211 0.0009

ALA 2211 MET 2212 0.0001

MET 2212 VAL 2213 0.0010

VAL 2213 PRO 2214 0.0001

PRO 2214 VAL 2215 0.0007

VAL 2215 ILE 2216 0.0001

ILE 2216 THR 2217 0.0009

THR 2217 ARG 2218 0.0009

ARG 2218 PRO 2219 0.0003

PRO 2219 PRO 2220 0.0013

PRO 2220 LYS 2221 0.0529

LYS 2221 LEU 2222 0.0165

LEU 2222 GLN 2223 0.0044

GLN 2223 LEU 2224 0.0163

LEU 2224 ARG 2225 0.0027

ARG 2225 PRO 2226 0.0165

PRO 2226 ASP 2227 0.0087

ASP 2227 ALA 2228 0.0105

ALA 2228 SER 2229 0.0072

SER 2229 TYR 2230 0.0035

TYR 2230 LEU 2231 0.0118

LEU 2231 ILE 2232 -0.0000

ILE 2232 VAL 2233 0.0123

VAL 2233 GLY 2234 0.0042

GLY 2234 GLY 2235 0.0137

GLY 2235 LEU 2236 0.0101

LEU 2236 GLY 2237 0.0413

GLY 2237 GLY 2238 0.0116

GLY 2238 ILE 2239 0.0113

ILE 2239 GLY 2240 0.0042

GLY 2240 ARG 2241 0.0143

ARG 2241 SER 2242 0.0141

SER 2242 LEU 2243 0.0056

LEU 2243 CYS 2244 0.0098

CYS 2244 LYS 2245 0.0139

LYS 2245 ASN 2246 0.0139

ASN 2246 PHE 2247 0.0035

PHE 2247 VAL 2248 0.0127

VAL 2248 GLU 2249 0.0133

GLU 2249 ASN 2250 0.0113

ASN 2250 GLY 2251 0.0038

GLY 2251 ALA 2252 0.0143

ALA 2252 ARG 2253 0.0202

ARG 2253 SER 2254 0.0167

SER 2254 LEU 2255 0.0047

LEU 2255 VAL 2256 0.0163

VAL 2256 LEU 2257 0.0016

LEU 2257 LEU 2258 0.0159

LEU 2258 SER 2259 0.0046

SER 2259 ARG 2260 0.0147

ARG 2260 ASN 2261 0.0155

ASN 2261 ALA 2262 0.0083

ALA 2262 ASN 2263 0.0159

ASN 2263 VAL 2264 0.0057

VAL 2264 SER 2265 0.0104

SER 2265 GLN 2266 0.0077

GLN 2266 GLN 2267 0.0106

GLN 2267 SER 2268 0.0073

SER 2268 GLY 2269 -0.0151

GLY 2269 GLU 2270 0.0160

GLU 2270 PHE 2271 0.0160

PHE 2271 LEU 2272 0.0039

LEU 2272 ASP 2273 0.0165

ASP 2273 GLU 2274 0.0158

GLU 2274 LEU 2275 0.0095

LEU 2275 ARG 2276 0.0088

ARG 2276 SER 2277 0.0166

SER 2277 THR 2278 0.0149

THR 2278 GLY 2279 0.0043

GLY 2279 CYS 2280 0.0162

CYS 2280 ILE 2281 0.0153

ILE 2281 VAL 2282 0.0062

VAL 2282 GLY 2283 0.0165

GLY 2283 VAL 2284 0.0045

VAL 2284 VAL 2285 -0.0340

VAL 2285 ASP 2286 0.0104

ASP 2286 CYS 2287 0.0164

CYS 2287 ASP 2288 0.0096

ASP 2288 ILE 2289 0.0143

ILE 2289 SER 2290 0.0131

SER 2290 SER 2291 0.0089

SER 2291 LYS 2292 0.0040

LYS 2292 THR 2293 0.0124

THR 2293 GLN 2294 0.0143

GLN 2294 VAL 2295 0.0155

VAL 2295 GLU 2296 0.0019

GLU 2296 ALA 2297 0.0163

ALA 2297 THR 2298 0.0138

THR 2298 MET 2299 0.0106

MET 2299 LEU 2300 0.0058

LEU 2300 ARG 2301 0.0177

ARG 2301 LEU 2302 0.0161

LEU 2302 LYS 2303 0.0037

LYS 2303 LYS 2304 0.0139

LYS 2304 ASP 2305 0.0106

ASP 2305 MET 2306 0.0152

MET 2306 LEU 2307 0.0146

LEU 2307 PRO 2308 0.0169

PRO 2308 ILE 2309 0.0025

ILE 2309 ARG 2310 0.0164

ARG 2310 GLY 2311 0.0003

GLY 2311 ILE 2312 0.0062

ILE 2312 VAL 2313 0.0005

VAL 2313 HIS 2314 0.0116

HIS 2314 ALA 2315 0.0039

ALA 2315 GLY 2316 0.0163

GLY 2316 MET 2317 -0.0340

MET 2317 VAL 2318 0.0133

VAL 2318 LEU 2319 0.0011

LEU 2319 GLN 2320 0.0158

GLN 2320 ASP 2321 0.0056

ASP 2321 SER 2322 0.0155

SER 2322 VAL 2323 0.0163

VAL 2323 PHE 2324 0.0140

PHE 2324 GLU 2325 0.0139

GLU 2325 ARG 2326 0.0218

ARG 2326 MET 2327 0.0022

MET 2327 SER 2328 0.0152

SER 2328 LEU 2329 0.0032

LEU 2329 ASP 2330 0.0198

ASP 2330 ASP 2331 0.0158

ASP 2331 TYR 2332 0.0190

TYR 2332 ASN 2333 -0.0010

ASN 2333 THR 2334 0.0200

THR 2334 ALA 2335 0.0187

ALA 2335 ILE 2336 0.0128

ILE 2336 ARG 2337 0.0062

ARG 2337 PRO 2338 0.0189

PRO 2338 LYS 2339 0.0196

LYS 2339 VAL 2340 0.0177

VAL 2340 GLN 2341 0.0102

GLN 2341 GLY 2342 0.0194

GLY 2342 SER 2343 0.0197

SER 2343 TRP 2344 0.0140

TRP 2344 ASN 2345 0.0141

ASN 2345 LEU 2346 0.0199

LEU 2346 HIS 2347 0.0192

HIS 2347 SER 2348 0.0116

SER 2348 GLY 2349 0.0227

GLY 2349 LEU 2350 0.0169

LEU 2350 SER 2351 0.0147

SER 2351 ASP 2352 0.0040

ASP 2352 CYS 2353 0.0161

CYS 2353 ASP 2354 0.0178

ASP 2354 LEU 2355 0.0031

LEU 2355 ASP 2356 0.0173

ASP 2356 PHE 2357 0.0016

PHE 2357 PHE 2358 0.0121

PHE 2358 ILE 2359 0.0012

ILE 2359 MET 2360 0.0079

MET 2360 LEU 2361 0.0042

LEU 2361 SER 2362 0.0118

SER 2362 SER 2363 0.0005

SER 2363 LEU 2364 0.0104

LEU 2364 ALA 2365 0.0181

ALA 2365 GLY 2366 0.0112

GLY 2366 VAL 2367 0.0201

VAL 2367 SER 2368 0.0007

SER 2368 GLY 2369 0.0207

GLY 2369 SER 2370 0.0162

SER 2370 ALA 2371 0.0106

ALA 2371 SER 2372 0.0196

SER 2372 GLN 2373 0.0019

GLN 2373 ALA 2374 0.0194

ALA 2374 ASN 2375 0.0072

ASN 2375 TYR 2376 0.0204

TYR 2376 THR 2377 0.0208

THR 2377 ALA 2378 0.0136

ALA 2378 GLY 2379 0.0110

GLY 2379 GLY 2380 0.0213

GLY 2380 ALA 2381 0.0245

ALA 2381 TYR 2382 0.0065

TYR 2382 GLN 2383 0.0161

GLN 2383 ASP 2384 0.0192

ASP 2384 ALA 2385 0.0167

ALA 2385 LEU 2386 0.0082

LEU 2386 ALA 2387 0.0197

ALA 2387 LYS 2388 0.0201

LYS 2388 TYR 2389 0.0130

TYR 2389 ARG 2390 0.0119

ARG 2390 ARG 2391 0.0200

ARG 2391 ALA 2392 0.0196

ALA 2392 GLN 2393 0.0075

GLN 2393 GLY 2394 0.0180

GLY 2394 LEU 2395 0.0190

LEU 2395 SER 2396 0.0148

SER 2396 ALA 2397 -0.0018

ALA 2397 VAL 2398 0.0048

VAL 2398 SER 2399 0.0029

SER 2399 ILE 2400 0.0105

ILE 2400 ASP 2401 0.0021

ASP 2401 LEU 2402 0.0164

LEU 2402 GLY 2403 0.0020

GLY 2403 MET 2404 0.0133

MET 2404 VAL 2405 0.0127

VAL 2405 GLN 2406 0.0117

GLN 2406 SER 2407 0.0127

SER 2407 VAL 2408 0.0119

VAL 2408 GLY 2409 0.0179

GLY 2409 TYR 2410 0.0085

TYR 2410 VAL 2411 0.0094

VAL 2411 ALA 2412 0.0174

ALA 2412 GLU 2413 0.0154

GLU 2413 THR 2414 0.0054

THR 2414 LYS 2415 0.0037

LYS 2415 GLY 2416 0.0113

GLY 2416 VAL 2417 0.0097

VAL 2417 ALA 2418 0.0171

ALA 2418 GLU 2419 0.0013

GLU 2419 ARG 2420 0.0172

ARG 2420 LEU 2421 0.0067

LEU 2421 VAL 2422 0.0162

VAL 2422 ARG 2423 0.0036

ARG 2423 MET 2424 0.0136

MET 2424 GLY 2425 0.0139

GLY 2425 TYR 2426 0.0042

TYR 2426 SER 2427 0.0147

SER 2427 PRO 2428 0.0146

PRO 2428 ILE 2429 -0.0108

ILE 2429 SER 2430 0.0125

SER 2430 GLU 2431 0.0054

GLU 2431 MET 2432 0.0111

MET 2432 GLU 2433 0.0140

GLU 2433 VAL 2434 0.0131

VAL 2434 LEU 2435 0.0040

LEU 2435 LYS 2436 0.0142

LYS 2436 ILE 2437 0.0140

ILE 2437 VAL 2438 0.0081

VAL 2438 GLU 2439 0.0085

GLU 2439 HIS 2440 0.0142

HIS 2440 ALA 2441 0.0142

ALA 2441 ILE 2442 0.0033

ILE 2442 THR 2443 0.0134

THR 2443 ASN 2444 0.0128

ASN 2444 PRO 2445 0.0636

PRO 2445 PRO 2446 0.0162

PRO 2446 PRO 2447 0.0118

PRO 2447 GLU 2448 0.0169

GLU 2448 ALA 2449 0.0194

ALA 2449 SER 2450 0.0032

SER 2450 SER 2451 0.0207

SER 2451 ALA 2452 0.0193

ALA 2452 GLN 2453 0.0017

GLN 2453 ILE 2454 0.0170

ILE 2454 ILE 2455 0.0001

ILE 2455 THR 2456 0.0168

THR 2456 GLY 2457 0.0043

GLY 2457 ILE 2458 0.0131

ILE 2458 SER 2459 0.0106

SER 2459 THR 2460 0.0210

THR 2460 LYS 2461 0.0038

LYS 2461 PRO 2462 0.0036

PRO 2462 GLY 2463 0.0133

GLY 2463 ARG 2464 0.0130

ARG 2464 HIS 2465 0.0092

HIS 2465 TRP 2466 0.0215

TRP 2466 THR 2467 0.0040

THR 2467 GLU 2468 0.0218

GLU 2468 SER 2469 0.0036

SER 2469 SER 2470 0.0220

SER 2470 TRP 2471 0.0001

TRP 2471 LEU 2472 0.0220

LEU 2472 GLN 2473 0.0159

GLN 2473 ASP 2474 0.0085

ASP 2474 ALA 2475 0.0178

ALA 2475 ARG 2476 0.0058

ARG 2476 PHE 2477 0.0256

PHE 2477 ALA 2478 0.0178

ALA 2478 THR 2479 0.0127

THR 2479 LEU 2480 0.0223

LEU 2480 ARG 2481 0.0003

ARG 2481 GLU 2482 0.0227

GLU 2482 ARG 2483 0.0143

ARG 2483 ALA 2484 0.0120

ALA 2484 ARG 2485 0.0116

ARG 2485 ASP 2486 0.0161

ASP 2486 VAL 2487 0.0225

VAL 2487 LYS 2488 0.0002

LYS 2488 GLU 2489 0.0221

GLU 2489 LEU 2490 0.0117

LEU 2490 SER 2491 0.0153

SER 2491 ASN 2492 0.0081

ASN 2492 SER 2493 0.0377

SER 2493 GLN 2494 0.0180

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** sdgklnrdh ***

CA strain for 22101813491974862

--- normal mode 8 ---

Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *