Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *

CA strain for 22101813491974862

--- normal mode 7 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
ASN 989 LYS 990 -0.0001

LYS 990 ALA 991 0.0002

ALA 991 HIS 992 0.0001

HIS 992 ARG 993 0.0001

ARG 993 GLN 994 -0.0000

GLN 994 ARG 995 -0.0001

ARG 995 VAL 996 0.0001

VAL 996 HIS 997 -0.0000

HIS 997 PRO 998 -0.0000

PRO 998 PRO 999 -0.0000

PRO 999 HIS 1000 -0.0000

HIS 1000 ASP 1001 0.0001

ASP 1001 LEU 1002 -0.0000

LEU 1002 LEU 1003 -0.0000

LEU 1003 GLY 1004 0.0000

GLY 1004 SER 1005 -0.0183

SER 1005 LEU 1006 -0.0000

LEU 1006 ILE 1007 -0.0001

ILE 1007 VAL 1008 0.0001

VAL 1008 GLY 1009 0.0000

GLY 1009 ARG 1010 -0.0001

ARG 1010 ASP 1011 0.0001

ASP 1011 LEU 1012 0.0002

LEU 1012 ARG 1013 -0.0001

ARG 1013 GLU 1014 -0.0001

GLU 1014 PRO 1015 0.0001

PRO 1015 THR 1016 -0.0000

THR 1016 TRP 1017 -0.0001

TRP 1017 ARG 1018 0.0000

ARG 1018 HIS 1019 -0.0001

HIS 1019 PHE 1020 -0.0000

PHE 1020 ILE 1021 0.0167

ILE 1021 ARG 1022 -0.0000

ARG 1022 VAL 1023 0.0003

VAL 1023 GLN 1024 0.0003

GLN 1024 ASP 1025 -0.0000

ASP 1025 ILE 1026 0.0005

ILE 1026 PRO 1027 0.0002

PRO 1027 TRP 1028 0.0004

TRP 1028 ILE 1029 0.0004

ILE 1029 ARG 1030 0.0002

ARG 1030 ASP 1031 0.0001

ASP 1031 HIS 1032 0.0003

HIS 1032 VAL 1033 0.0002

VAL 1033 VAL 1034 0.0004

VAL 1034 GLN 1035 0.0004

GLN 1035 SER 1036 0.0003

SER 1036 ALA 1037 0.0182

ALA 1037 LEU 1038 0.0000

LEU 1038 VAL 1039 0.0001

VAL 1039 TYR 1040 0.0003

TYR 1040 PRO 1041 0.0001

PRO 1041 GLY 1042 0.0002

GLY 1042 ALA 1043 0.0003

ALA 1043 GLY 1044 0.0003

GLY 1044 PHE 1045 0.0002

PHE 1045 ILE 1046 0.0001

ILE 1046 CYS 1047 0.0003

CYS 1047 MET 1048 0.0006

MET 1048 ALA 1049 0.0001

ALA 1049 MET 1050 0.0004

MET 1050 GLU 1051 0.0003

GLU 1051 ALA 1052 0.0002

ALA 1052 MET 1053 0.0135

MET 1053 VAL 1054 0.0000

VAL 1054 GLN 1055 -0.0002

GLN 1055 LEU 1056 -0.0001

LEU 1056 HIS 1057 0.0002

HIS 1057 GLU 1058 0.0001

GLU 1058 LEU 1059 -0.0000

LEU 1059 ARG 1060 0.0001

ARG 1060 ASP 1061 0.0003

ASP 1061 SER 1062 0.0001

SER 1062 GLN 1063 0.0001

GLN 1063 SER 1064 0.0001

SER 1064 ARG 1065 0.0001

ARG 1065 LYS 1066 0.0003

LYS 1066 VAL 1067 0.0001

VAL 1067 ALA 1068 0.0001

ALA 1068 GLY 1069 0.0053

GLY 1069 TYR 1070 0.0005

TYR 1070 ARG 1071 0.0002

ARG 1071 LEU 1072 0.0001

LEU 1072 ALA 1073 0.0003

ALA 1073 GLU 1074 0.0002

GLU 1074 VAL 1075 0.0000

VAL 1075 ASP 1076 0.0001

ASP 1076 ILE 1077 0.0001

ILE 1077 LEU 1078 0.0002

LEU 1078 ARG 1079 -0.0002

ARG 1079 ALA 1080 0.0002

ALA 1080 MET 1081 0.0002

MET 1081 LEU 1082 -0.0002

LEU 1082 ILE 1083 0.0003

ILE 1083 PRO 1084 0.0000

PRO 1084 ASP 1085 -0.0082

ASP 1085 THR 1086 -0.0002

THR 1086 SER 1087 0.0002

SER 1087 GLU 1088 -0.0001

GLU 1088 GLY 1089 -0.0000

GLY 1089 LEU 1090 0.0000

LEU 1090 GLU 1091 0.0001

GLU 1091 ALA 1092 -0.0001

ALA 1092 HIS 1093 0.0002

HIS 1093 ILE 1094 0.0001

ILE 1094 SER 1095 -0.0000

SER 1095 LEU 1096 0.0001

LEU 1096 ARG 1097 -0.0000

ARG 1097 PRO 1098 0.0001

PRO 1098 CYS 1099 0.0002

CYS 1099 SER 1100 -0.0001

SER 1100 THR 1101 -0.0107

THR 1101 LYS 1102 0.0001

LYS 1102 LEU 1103 0.0002

LEU 1103 LEU 1104 0.0000

LEU 1104 LEU 1105 -0.0000

LEU 1105 THR 1106 0.0001

THR 1106 ASN 1107 -0.0001

ASN 1107 GLU 1108 0.0001

GLU 1108 TRP 1109 -0.0001

TRP 1109 TYR 1110 0.0002

TYR 1110 ASP 1111 -0.0001

ASP 1111 PHE 1112 0.0001

PHE 1112 CYS 1113 -0.0000

CYS 1113 VAL 1114 -0.0000

VAL 1114 SER 1115 0.0003

SER 1115 SER 1116 0.0001

SER 1116 VAL 1117 0.0042

VAL 1117 GLY 1118 -0.0001

GLY 1118 ASP 1119 0.0002

ASP 1119 ASP 1120 -0.0000

ASP 1120 ASP 1121 -0.0000

ASP 1121 LYS 1122 0.0002

LYS 1122 PHE 1123 0.0000

PHE 1123 VAL 1124 0.0001

VAL 1124 ASP 1125 0.0001

ASP 1125 HIS 1126 0.0003

HIS 1126 CYS 1127 0.0000

CYS 1127 ARG 1128 -0.0000

ARG 1128 GLY 1129 0.0000

GLY 1129 ARG 1130 0.0001

ARG 1130 ILE 1131 0.0001

ILE 1131 THR 1132 0.0000

THR 1132 ILE 1133 0.0063

ILE 1133 GLU 1134 0.0003

GLU 1134 PHE 1135 0.0004

PHE 1135 ASP 1136 0.0005

ASP 1136 THR 1137 0.0002

THR 1137 SER 1138 0.0004

SER 1138 GLY 1139 0.0002

GLY 1139 SER 1140 0.0006

SER 1140 ALA 1141 0.0005

ALA 1141 ASP 1142 0.0004

ASP 1142 THR 1143 0.0007

THR 1143 PRO 1144 0.0006

PRO 1144 ARG 1145 0.0001

ARG 1145 THR 1146 0.0007

THR 1146 SER 1147 0.0005

SER 1147 LEU 1148 0.0004

LEU 1148 ARG 1149 -0.0158

ARG 1149 GLU 1150 0.0014

GLU 1150 ARG 1151 0.0013

ARG 1151 SER 1152 0.0009

SER 1152 ARG 1153 0.0019

ARG 1153 SER 1154 0.0015

SER 1154 THR 1155 0.0016

THR 1155 GLY 1156 0.0002

GLY 1156 LEU 1157 0.0004

LEU 1157 MET 1158 0.0021

MET 1158 ARG 1159 0.0001

ARG 1159 SER 1160 0.0018

SER 1160 VAL 1161 0.0015

VAL 1161 ASP 1162 0.0014

ASP 1162 PRO 1163 0.0022

PRO 1163 SER 1164 0.0002

SER 1164 ASN 1165 0.0388

ASN 1165 LEU 1166 0.0001

LEU 1166 TYR 1167 0.0007

TYR 1167 SER 1168 0.0003

SER 1168 PHE 1169 0.0006

PHE 1169 LEU 1170 0.0005

LEU 1170 ARG 1171 0.0000

ARG 1171 ALA 1172 0.0006

ALA 1172 GLN 1173 0.0003

GLN 1173 GLY 1174 0.0008

GLY 1174 ILE 1175 0.0002

ILE 1175 TYR 1176 0.0005

TYR 1176 HIS 1177 0.0006

HIS 1177 GLY 1178 0.0003

GLY 1178 PRO 1179 0.0007

PRO 1179 ILE 1180 0.0001

ILE 1180 PHE 1181 -0.0089

PHE 1181 GLN 1182 0.0007

GLN 1182 ASN 1183 0.0004

ASN 1183 LEU 1184 0.0009

LEU 1184 LYS 1185 0.0010

LYS 1185 THR 1186 0.0009

THR 1186 ILE 1187 0.0007

ILE 1187 SER 1188 0.0007

SER 1188 SER 1189 0.0009

SER 1189 ARG 1190 0.0008

ARG 1190 LYS 1191 0.0008

LYS 1191 ASP 1192 0.0005

ASP 1192 HIS 1193 0.0009

HIS 1193 SER 1194 0.0005

SER 1194 GLU 1195 0.0009

GLU 1195 SER 1196 0.0007

SER 1196 SER 1197 -0.0219

SER 1197 PHE 1198 0.0005

PHE 1198 VAL 1199 0.0005

VAL 1199 VAL 1200 0.0005

VAL 1200 ALA 1201 0.0001

ALA 1201 ASN 1202 0.0006

ASN 1202 THR 1203 0.0005

THR 1203 ALA 1204 0.0005

ALA 1204 SER 1205 0.0001

SER 1205 VAL 1206 0.0005

VAL 1206 MET 1207 0.0004

MET 1207 PRO 1208 0.0003

PRO 1208 ASN 1209 0.0004

ASN 1209 GLY 1210 0.0005

GLY 1210 PHE 1211 0.0001

PHE 1211 GLN 1212 0.0004

GLN 1212 SER 1213 0.0048

SER 1213 PRO 1214 0.0001

PRO 1214 HIS 1215 0.0004

HIS 1215 VAL 1216 0.0003

VAL 1216 ILE 1217 0.0000

ILE 1217 HIS 1218 0.0001

HIS 1218 PRO 1219 0.0004

PRO 1219 THR 1220 0.0002

THR 1220 THR 1221 0.0003

THR 1221 LEU 1222 0.0003

LEU 1222 ASP 1223 -0.0000

ASP 1223 SER 1224 0.0003

SER 1224 ILE 1225 0.0000

ILE 1225 PHE 1226 0.0005

PHE 1226 GLN 1227 0.0001

GLN 1227 GLY 1228 0.0003

GLY 1228 ALA 1229 -0.0167

ALA 1229 TYR 1230 0.0002

TYR 1230 THR 1231 0.0009

THR 1231 ALA 1232 0.0003

ALA 1232 LEU 1233 0.0006

LEU 1233 PRO 1234 0.0006

PRO 1234 GLY 1235 -0.0000

GLY 1235 ALA 1236 0.0006

ALA 1236 GLY 1237 0.0009

GLY 1237 LEU 1238 -0.0001

LEU 1238 ASP 1239 0.0007

ASP 1239 GLN 1240 0.0007

GLN 1240 ASN 1241 0.0006

ASN 1241 THR 1242 0.0008

THR 1242 ALA 1243 0.0007

ALA 1243 MET 1244 0.0003

MET 1244 ILE 1245 0.0188

ILE 1245 PRO 1246 -0.0001

PRO 1246 ARG 1247 0.0003

ARG 1247 SER 1248 -0.0001

SER 1248 ILE 1249 0.0004

ILE 1249 GLN 1250 0.0002

GLN 1250 GLU 1251 0.0005

GLU 1251 LEU 1252 0.0001

LEU 1252 TYR 1253 0.0004

TYR 1253 LEU 1254 0.0005

LEU 1254 SER 1255 0.0004

SER 1255 SER 1256 0.0004

SER 1256 ALA 1257 0.0003

ALA 1257 LEU 1258 0.0002

LEU 1258 THR 1259 0.0001

THR 1259 SER 1260 0.0002

SER 1260 ASP 1261 0.0004

ASP 1261 VAL 1262 0.0001

VAL 1262 GLY 1263 0.0007

GLY 1263 GLN 1264 0.0002

GLN 1264 CYS 1265 0.0006

CYS 1265 LEU 1266 0.0003

LEU 1266 VAL 1267 0.0006

VAL 1267 SER 1268 0.0004

SER 1268 ASP 1269 0.0006

ASP 1269 THR 1270 0.0005

THR 1270 SER 1271 0.0007

SER 1271 LEU 1272 0.0005

LEU 1272 ILE 1273 0.0005

ILE 1273 ARG 1274 0.0005

ARG 1274 TYR 1275 -0.0001

TYR 1275 ASP 1276 0.0005

ASP 1276 GLY 1277 0.0003

GLY 1277 GLN 1278 0.0005

GLN 1278 SER 1279 0.0005

SER 1279 PHE 1280 0.0006

PHE 1280 THR 1281 0.0002

THR 1281 VAL 1282 0.0008

VAL 1282 ASN 1283 0.0004

ASN 1283 VAL 1284 0.0005

VAL 1284 ASP 1285 0.0007

ASP 1285 VAL 1286 0.0007

VAL 1286 SER 1287 0.0007

SER 1287 SER 1288 0.0003

SER 1288 LYS 1289 0.0004

LYS 1289 ALA 1290 0.0007

ALA 1290 ASP 1291 0.0003

ASP 1291 SER 1292 0.0005

SER 1292 GLU 1293 0.0104

GLU 1293 HIS 1294 0.0005

HIS 1294 THR 1295 0.0004

THR 1295 PRO 1296 0.0006

PRO 1296 VAL 1297 0.0006

VAL 1297 LEU 1298 0.0005

LEU 1298 GLU 1299 0.0006

GLU 1299 ILE 1300 0.0007

ILE 1300 LYS 1301 0.0003

LYS 1301 GLY 1302 0.0005

GLY 1302 LEU 1303 0.0002

LEU 1303 ARG 1304 0.0005

ARG 1304 ASN 1305 0.0000

ASN 1305 GLN 1306 0.0004

GLN 1306 SER 1307 0.0002

SER 1307 VAL 1308 0.0005

VAL 1308 GLY 1309 -0.0457

GLY 1309 GLN 1310 0.0072

GLN 1310 MET 1311 0.0133

MET 1311 ALA 1312 0.0133

ALA 1312 PRO 1313 0.0015

PRO 1313 GLN 1314 0.0133

GLN 1314 PRO 1315 0.0128

PRO 1315 GLY 1316 0.0008

GLY 1316 ASP 1317 0.0129

ASP 1317 SER 1318 0.0133

SER 1318 SER 1319 0.0043

SER 1319 ASN 1320 0.0062

ASN 1320 ASN 1321 0.0135

ASN 1321 ASP 1322 0.0059

ASP 1322 LEU 1323 0.0073

LEU 1323 CYS 1324 0.0075

CYS 1324 PHE 1325 0.0254

PHE 1325 LYS 1326 0.0126

LYS 1326 LEU 1327 0.0087

LEU 1327 ASP 1328 0.0312

ASP 1328 TRP 1329 0.0088

TRP 1329 ALA 1330 0.0308

ALA 1330 PRO 1331 0.0177

PRO 1331 ASP 1332 0.0302

ASP 1332 ILE 1333 0.0275

ILE 1333 SER 1334 0.0192

SER 1334 SER 1335 0.0117

SER 1335 VAL 1336 0.0278

VAL 1336 LYS 1337 0.0214

LYS 1337 GLN 1338 0.0247

GLN 1338 GLU 1339 0.0256

GLU 1339 ARG 1340 0.0262

ARG 1340 LEU 1341 -0.0210

LEU 1341 LYS 1342 0.0373

LYS 1342 GLU 1343 0.0347

GLU 1343 LYS 1344 0.0162

LYS 1344 PHE 1345 0.0180

PHE 1345 GLY 1346 0.0350

GLY 1346 PHE 1347 0.0281

PHE 1347 PRO 1348 0.0319

PRO 1348 LEU 1349 0.0322

LEU 1349 ASP 1350 0.0182

ASP 1350 PRO 1351 0.0377

PRO 1351 THR 1352 0.0006

THR 1352 GLU 1353 0.0376

GLU 1353 ALA 1354 0.0197

ALA 1354 ASP 1355 0.0275

ASP 1355 ILE 1356 0.0120

ILE 1356 ILE 1357 0.0357

ILE 1357 MET 1358 0.0350

MET 1358 GLY 1359 0.0047

GLY 1359 LEU 1360 0.0349

LEU 1360 ARG 1361 0.0213

ARG 1361 GLN 1362 0.0349

GLN 1362 ALA 1363 0.0028

ALA 1363 CYS 1364 0.0372

CYS 1364 ILE 1365 0.0304

ILE 1365 HIS 1366 0.0147

HIS 1366 PHE 1367 0.0235

PHE 1367 ILE 1368 0.0247

ILE 1368 HIS 1369 0.0377

HIS 1369 ARG 1370 0.0016

ARG 1370 SER 1371 0.0362

SER 1371 LEU 1372 0.0206

LEU 1372 GLN 1373 0.0359

GLN 1373 SER 1374 0.0035

SER 1374 LEU 1375 0.0374

LEU 1375 THR 1376 0.0358

THR 1376 ALA 1377 0.0326

ALA 1377 PRO 1378 0.0134

PRO 1378 ASP 1379 0.0382

ASP 1379 ARG 1380 0.0044

ARG 1380 ASP 1381 0.0367

ASP 1381 GLN 1382 0.0199

GLN 1382 LEU 1383 0.0239

LEU 1383 ASP 1384 0.0383

ASP 1384 TRP 1385 0.0065

TRP 1385 HIS 1386 0.0376

HIS 1386 GLN 1387 0.0335

GLN 1387 LYS 1388 0.0225

LYS 1388 ARG 1389 0.0203

ARG 1389 PHE 1390 0.0328

PHE 1390 TYR 1391 0.0384

TYR 1391 ASP 1392 0.0030

ASP 1392 TRP 1393 0.0367

TRP 1393 MET 1394 0.0279

MET 1394 VAL 1395 0.0290

VAL 1395 LEU 1396 0.0101

LEU 1396 GLN 1397 0.0357

GLN 1397 ILE 1398 0.0372

ILE 1398 GLN 1399 0.0081

GLN 1399 LEU 1400 0.0317

LEU 1400 ALA 1401 0.0291

ALA 1401 GLU 1402 0.0347

GLU 1402 GLU 1403 0.0049

GLU 1403 ASP 1404 0.0383

ASP 1404 ARG 1405 0.0357

ARG 1405 LEU 1406 0.0141

LEU 1406 ALA 1407 0.0350

ALA 1407 PRO 1408 0.0283

PRO 1408 ASN 1409 0.0273

ASN 1409 SER 1410 0.0205

SER 1410 SER 1411 0.0382

SER 1411 ALA 1412 0.0304

ALA 1412 TRP 1413 0.0193

TRP 1413 LEU 1414 0.0347

LEU 1414 GLN 1415 0.0374

GLN 1415 CYS 1416 0.0251

CYS 1416 SER 1417 0.0149

SER 1417 SER 1418 0.0080

SER 1418 SER 1419 0.0379

SER 1419 ASP 1420 0.0088

ASP 1420 GLU 1421 0.0375

GLU 1421 GLN 1422 0.0099

GLN 1422 LYS 1423 0.0312

LYS 1423 LEU 1424 0.0200

LEU 1424 LEU 1425 0.0205

LEU 1425 GLU 1426 0.0284

GLU 1426 ASN 1427 0.0125

ASN 1427 VAL 1428 0.0353

VAL 1428 ARG 1429 0.0067

ARG 1429 ALA 1430 0.0386

ALA 1430 SER 1431 0.0044

SER 1431 SER 1432 0.0386

SER 1432 VAL 1433 0.0280

VAL 1433 ASN 1434 0.0231

ASN 1434 GLY 1435 0.0352

GLY 1435 GLN 1436 0.0032

GLN 1436 MET 1437 0.0380

MET 1437 VAL 1438 0.0272

VAL 1438 VAL 1439 0.0212

VAL 1439 HIS 1440 0.0167

HIS 1440 VAL 1441 0.0321

VAL 1441 GLY 1442 0.0306

GLY 1442 LYS 1443 0.0120

LYS 1443 SER 1444 0.0322

SER 1444 MET 1445 0.0129

MET 1445 LEU 1446 0.0346

LEU 1446 ALA 1447 0.0090

ALA 1447 ILE 1448 0.0295

ILE 1448 LEU 1449 0.0270

LEU 1449 ARG 1450 0.0109

ARG 1450 HIS 1451 0.0331

HIS 1451 GLU 1452 0.0196

GLU 1452 ILE 1453 0.0353

ILE 1453 ALA 1454 0.0326

ALA 1454 PRO 1455 0.0134

PRO 1455 LEU 1456 0.0387

LEU 1456 GLU 1457 0.0041

GLU 1457 LEU 1458 0.0359

LEU 1458 MET 1459 0.0195

MET 1459 LEU 1460 0.0233

LEU 1460 GLN 1461 0.0242

GLN 1461 ASP 1462 0.0388

ASP 1462 LYS 1463 0.0243

LYS 1463 LEU 1464 0.0187

LEU 1464 LEU 1465 0.0278

LEU 1465 TYR 1466 0.0385

TYR 1466 ARG 1467 0.0358

ARG 1467 TYR 1468 0.0180

TYR 1468 TYR 1469 0.0301

TYR 1469 THR 1470 0.0376

THR 1470 ASP 1471 0.0371

ASP 1471 ALA 1472 0.0267

ALA 1472 ILE 1473 0.0073

ILE 1473 LYS 1474 0.0155

LYS 1474 TRP 1475 0.0257

TRP 1475 ASP 1476 0.0376

ASP 1476 ARG 1477 0.0001

ARG 1477 SER 1478 0.0373

SER 1478 TYR 1479 0.0196

TYR 1479 GLN 1480 0.0294

GLN 1480 GLN 1481 0.0122

GLN 1481 ILE 1482 0.0275

ILE 1482 ASP 1483 0.0319

ASP 1483 GLN 1484 0.0061

GLN 1484 LEU 1485 0.0333

LEU 1485 VAL 1486 0.0132

VAL 1486 LYS 1487 0.0350

LYS 1487 LEU 1488 0.0037

LEU 1488 HIS 1489 0.0332

HIS 1489 ALA 1490 0.0145

ALA 1490 HIS 1491 0.0234

HIS 1491 LYS 1492 0.0206

LYS 1492 CYS 1493 0.0188

CYS 1493 PRO 1494 0.0099

PRO 1494 THR 1495 0.0312

THR 1495 ALA 1496 0.0341

ALA 1496 LYS 1497 0.0232

LYS 1497 ILE 1498 0.0343

ILE 1498 ILE 1499 0.0302

ILE 1499 GLU 1500 0.0332

GLU 1500 ILE 1501 0.0411

ILE 1501 GLY 1502 0.0207

GLY 1502 ALA 1503 0.0330

ALA 1503 GLY 1504 0.0167

GLY 1504 THR 1505 0.0295

THR 1505 GLY 1506 0.0243

GLY 1506 GLY 1507 0.0252

GLY 1507 CYS 1508 0.0108

CYS 1508 THR 1509 0.0273

THR 1509 ARG 1510 0.0336

ARG 1510 ALA 1511 0.0042

ALA 1511 VAL 1512 0.0334

VAL 1512 LEU 1513 0.0169

LEU 1513 ASP 1514 0.0353

ASP 1514 ALA 1515 0.0028

ALA 1515 LEU 1516 0.0338

LEU 1516 SER 1517 0.0184

SER 1517 ASN 1518 0.0314

ASN 1518 GLN 1519 0.0140

GLN 1519 GLY 1520 0.0210

GLY 1520 ILE 1521 0.0267

ILE 1521 ALA 1522 0.0310

ALA 1522 ARG 1523 0.0027

ARG 1523 CYS 1524 0.0346

CYS 1524 ALA 1525 0.0314

ALA 1525 GLN 1526 0.0267

GLN 1526 TYR 1527 0.0348

TYR 1527 ASP 1528 0.0324

ASP 1528 PHE 1529 0.0281

PHE 1529 THR 1530 0.0352

THR 1530 ASP 1531 0.0324

ASP 1531 VAL 1532 0.0342

VAL 1532 SER 1533 0.0105

SER 1533 SER 1534 0.0231

SER 1534 GLY 1535 0.0301

GLY 1535 PHE 1536 0.0285

PHE 1536 PHE 1537 0.0366

PHE 1537 GLU 1538 0.0075

GLU 1538 ALA 1539 0.0333

ALA 1539 ALA 1540 0.0099

ALA 1540 GLN 1541 0.0290

GLN 1541 GLN 1542 0.0255

GLN 1542 LYS 1543 0.0131

LYS 1543 PHE 1544 0.0258

PHE 1544 ALA 1545 0.0193

ALA 1545 ALA 1546 0.0254

ALA 1546 PHE 1547 0.0212

PHE 1547 ASP 1548 0.0219

ASP 1548 ASP 1549 0.0381

ASP 1549 VAL 1550 0.0101

VAL 1550 ILE 1551 0.0337

ILE 1551 ARG 1552 0.0348

ARG 1552 PHE 1553 0.0318

PHE 1553 GLN 1554 0.0354

GLN 1554 LYS 1555 0.0369

LYS 1555 LEU 1556 0.0053

LEU 1556 ASP 1557 0.0339

ASP 1557 ILE 1558 0.0003

ILE 1558 GLU 1559 0.0359

GLU 1559 LYS 1560 0.0304

LYS 1560 ASP 1561 0.0316

ASP 1561 ILE 1562 0.0369

ILE 1562 GLU 1563 0.0358

GLU 1563 MET 1564 0.0166

MET 1564 GLN 1565 0.0329

GLN 1565 GLY 1566 0.0368

GLY 1566 PHE 1567 0.0130

PHE 1567 GLU 1568 0.0183

GLU 1568 CYS 1569 0.0058

CYS 1569 GLY 1570 0.0180

GLY 1570 SER 1571 0.0211

SER 1571 TYR 1572 0.0367

TYR 1572 ASP 1573 0.0213

ASP 1573 LEU 1574 0.0349

LEU 1574 VAL 1575 0.0315

VAL 1575 ILE 1576 0.0326

ILE 1576 ALA 1577 0.0360

ALA 1577 SER 1578 0.0345

SER 1578 GLN 1579 0.0363

GLN 1579 VAL 1580 0.0336

VAL 1580 LEU 1581 0.0123

LEU 1581 HIS 1582 0.0363

HIS 1582 ALA 1583 0.0088

ALA 1583 THR 1584 0.0322

THR 1584 GLY 1585 0.0344

GLY 1585 LYS 1586 0.0072

LYS 1586 MET 1587 0.0296

MET 1587 GLU 1588 0.0222

GLU 1588 HIS 1589 0.0150

HIS 1589 THR 1590 0.0273

THR 1590 MET 1591 0.0146

MET 1591 ALA 1592 0.0356

ALA 1592 ASN 1593 0.0052

ASN 1593 VAL 1594 0.0365

VAL 1594 ARG 1595 0.0125

ARG 1595 LYS 1596 0.0269

LYS 1596 LEU 1597 0.0278

LEU 1597 LEU 1598 0.0153

LEU 1598 LYS 1599 0.0281

LYS 1599 PRO 1600 0.0005

PRO 1600 GLY 1601 0.0345

GLY 1601 GLY 1602 0.0054

GLY 1602 LYS 1603 0.0364

LYS 1603 LEU 1604 0.0311

LEU 1604 LEU 1605 0.0330

LEU 1605 LEU 1606 0.0358

LEU 1606 VAL 1607 0.0316

VAL 1607 GLU 1608 0.0367

GLU 1608 THR 1609 0.0367

THR 1609 THR 1610 0.0016

THR 1610 ARG 1611 0.0367

ARG 1611 ASP 1612 0.0121

ASP 1612 GLU 1613 0.0470

GLU 1613 MET 1614 0.0262

MET 1614 ASP 1615 0.0116

ASP 1615 LEU 1616 0.0380

LEU 1616 GLN 1617 0.0368

GLN 1617 LEU 1618 0.0187

LEU 1618 VAL 1619 0.0206

VAL 1619 PHE 1620 0.0367

PHE 1620 GLY 1621 0.0335

GLY 1621 LEU 1622 0.0039

LEU 1622 LEU 1623 0.0376

LEU 1623 PRO 1624 0.0357

PRO 1624 GLY 1625 0.0304

GLY 1625 TRP 1626 0.0204

TRP 1626 TRP 1627 0.0338

TRP 1627 LEU 1628 0.0380

LEU 1628 SER 1629 -0.0029

SER 1629 SER 1630 0.0320

SER 1630 GLU 1631 0.0062

GLU 1631 GLU 1632 0.0306

GLU 1632 GLU 1633 0.0350

GLU 1633 ARG 1634 0.0046

ARG 1634 GLN 1635 0.0293

GLN 1635 MET 1636 0.0383

MET 1636 SER 1637 0.0378

SER 1637 PRO 1638 0.0347

PRO 1638 SER 1639 0.0207

SER 1639 LEU 1640 0.0058

LEU 1640 SER 1641 0.0151

SER 1641 THR 1642 0.0325

THR 1642 ASN 1643 0.0148

ASN 1643 SER 1644 0.0246

SER 1644 TRP 1645 0.0335

TRP 1645 GLU 1646 0.0076

GLU 1646 LYS 1647 0.0350

LYS 1647 VAL 1648 0.0068

VAL 1648 LEU 1649 0.0362

LEU 1649 LYS 1650 0.0072

LYS 1650 LYS 1651 0.0327

LYS 1651 THR 1652 0.0118

THR 1652 GLY 1653 0.0305

GLY 1653 PHE 1654 0.0360

PHE 1654 ASP 1655 0.0082

ASP 1655 GLY 1656 0.0351

GLY 1656 LEU 1657 0.0323

LEU 1657 ASP 1658 0.0349

ASP 1658 ILE 1659 0.0298

ILE 1659 GLU 1660 0.0330

GLU 1660 LEU 1661 0.0305

LEU 1661 ARG 1662 0.0343

ARG 1662 ASP 1663 0.0120

ASP 1663 CYS 1664 0.0236

CYS 1664 ASP 1665 0.0016

ASP 1665 SER 1666 0.0375

SER 1666 ASP 1667 0.0327

ASP 1667 GLU 1668 0.0228

GLU 1668 PHE 1669 0.0104

PHE 1669 TYR 1670 0.0374

TYR 1670 SER 1671 0.0228

SER 1671 PHE 1672 0.0369

PHE 1672 SER 1673 0.0216

SER 1673 VAL 1674 0.0361

VAL 1674 MET 1675 0.0250

MET 1675 MET 1676 0.0360

MET 1676 ALA 1677 0.0568

ALA 1677 THR 1678 0.0276

THR 1678 ALA 1679 0.0282

ALA 1679 SER 1680 0.0053

SER 1680 SER 1681 0.0278

SER 1681 THR 1682 0.0151

THR 1682 ILE 1683 0.0197

ILE 1683 ALA 1684 0.0279

ALA 1684 SER 1685 0.0013

SER 1685 SER 1686 0.0291

SER 1686 SER 1687 0.0086

SER 1687 MET 1688 0.0291

MET 1688 ALA 1689 0.0117

ALA 1689 PHE 1690 0.0292

PHE 1690 ALA 1691 0.0244

ALA 1691 ILE 1692 0.0287

ILE 1692 VAL 1693 0.0221

VAL 1693 TYR 1694 0.0235

TYR 1694 GLY 1695 0.0264

GLY 1695 GLU 1696 0.0121

GLU 1696 VAL 1697 0.0243

VAL 1697 PRO 1698 0.0234

PRO 1698 LEU 1699 0.0221

LEU 1699 PRO 1700 0.0176

PRO 1700 ASP 1701 0.0201

ASP 1701 GLN 1702 0.0240

GLN 1702 PHE 1703 0.0023

PHE 1703 LEU 1704 0.0262

LEU 1704 ASP 1705 0.0221

ASP 1705 ASP 1706 0.0135

ASP 1706 MET 1707 0.0148

MET 1707 LYS 1708 0.0220

LYS 1708 THR 1709 0.0308

THR 1709 ALA 1710 0.0023

ALA 1710 ILE 1711 0.0249

ILE 1711 SER 1712 0.0185

SER 1712 SER 1713 0.0226

SER 1713 SER 1714 0.0049

SER 1714 ALA 1715 0.0255

ALA 1715 VAL 1716 0.0206

VAL 1716 SER 1717 0.0168

SER 1717 ASP 1718 0.0148

ASP 1718 PRO 1719 0.0246

PRO 1719 VAL 1720 0.0193

VAL 1720 VAL 1721 0.0258

VAL 1721 GLY 1722 0.0265

GLY 1722 HIS 1723 0.0266

HIS 1723 LEU 1724 0.0083

LEU 1724 ASP 1725 0.0241

ASP 1725 SER 1726 0.0194

SER 1726 ILE 1727 0.0169

ILE 1727 ASP 1728 0.0216

ASP 1728 ALA 1729 0.0037

ALA 1729 THR 1730 0.0240

THR 1730 GLY 1731 0.0186

GLY 1731 LYS 1732 0.0246

LYS 1732 PHE 1733 0.0170

PHE 1733 CYS 1734 0.0223

CYS 1734 ILE 1735 0.0260

ILE 1735 PHE 1736 0.0253

PHE 1736 ILE 1737 0.0232

ILE 1737 GLU 1738 0.0260

GLU 1738 ASP 1739 0.0179

ASP 1739 PRO 1740 0.0160

PRO 1740 GLU 1741 0.0074

GLU 1741 THR 1742 0.0238

THR 1742 ASP 1743 0.0038

ASP 1743 ILE 1744 0.0235

ILE 1744 LEU 1745 0.0036

LEU 1745 SER 1746 0.0242

SER 1746 SER 1747 0.0127

SER 1747 PRO 1748 0.0217

PRO 1748 ASP 1749 0.0103

ASP 1749 GLU 1750 0.0246

GLU 1750 LYS 1751 0.0164

LYS 1751 SER 1752 0.0200

SER 1752 TYR 1753 0.0045

TYR 1753 ALA 1754 0.0227

ALA 1754 SER 1755 0.0209

SER 1755 ILE 1756 0.0066

ILE 1756 GLN 1757 0.0203

GLN 1757 LYS 1758 0.0160

LYS 1758 LEU 1759 0.0248

LEU 1759 VAL 1760 0.0000

VAL 1760 THR 1761 0.0251

THR 1761 ARG 1762 0.0143

ARG 1762 CYS 1763 0.0244

CYS 1763 LYS 1764 0.0162

LYS 1764 GLY 1765 0.0222

GLY 1765 LEU 1766 0.0232

LEU 1766 ILE 1767 0.0250

ILE 1767 TRP 1768 0.0243

TRP 1768 VAL 1769 0.0232

VAL 1769 SER 1770 0.0246

SER 1770 ARG 1771 0.0253

ARG 1771 GLY 1772 0.0123

GLY 1772 GLY 1773 0.0245

GLY 1773 ALA 1774 0.0074

ALA 1774 MET 1775 0.0169

MET 1775 HIS 1776 0.0215

HIS 1776 GLY 1777 0.0189

GLY 1777 THR 1778 0.0095

THR 1778 ARG 1779 0.0170

ARG 1779 PRO 1780 0.0143

PRO 1780 ASN 1781 0.0132

ASN 1781 SER 1782 0.0232

SER 1782 SER 1783 0.0024

SER 1783 LEU 1784 0.0223

LEU 1784 LYS 1785 0.0216

LYS 1785 THR 1786 0.0059

THR 1786 GLY 1787 0.0177

GLY 1787 LEU 1788 0.0149

LEU 1788 LEU 1789 0.0276

LEU 1789 ARG 1790 0.0004

ARG 1790 THR 1791 0.0242

THR 1791 LEU 1792 0.0134

LEU 1792 ARG 1793 0.0156

ARG 1793 LEU 1794 0.0143

LEU 1794 GLU 1795 0.0129

GLU 1795 TYR 1796 0.0202

TYR 1796 THR 1797 0.0120

THR 1797 GLU 1798 0.0160

GLU 1798 LYS 1799 0.0130

LYS 1799 ARG 1800 0.0241

ARG 1800 PHE 1801 0.0235

PHE 1801 ILE 1802 0.0245

ILE 1802 SER 1803 0.0239

SER 1803 LEU 1804 0.0206

LEU 1804 ASP 1805 0.0314

ASP 1805 LEU 1806 0.0169

LEU 1806 ASP 1807 0.0263

ASP 1807 SER 1808 0.0226

SER 1808 ALA 1809 0.0263

ALA 1809 ARG 1810 0.0168

ARG 1810 PRO 1811 0.0015

PRO 1811 GLN 1812 0.0256

GLN 1812 TRP 1813 0.0208

TRP 1813 ASN 1814 0.0244

ASN 1814 HIS 1815 0.0255

HIS 1815 ASP 1816 0.0017

ASP 1816 SER 1817 0.0264

SER 1817 ILE 1818 0.0221

ILE 1818 THR 1819 0.0142

THR 1819 THR 1820 0.0121

THR 1820 ILE 1821 0.0236

ILE 1821 ASN 1822 0.0284

ASN 1822 GLU 1823 0.0048

GLU 1823 VAL 1824 0.0245

VAL 1824 LEU 1825 0.0198

LEU 1825 CYS 1826 0.0266

CYS 1826 GLY 1827 0.0033

GLY 1827 ALA 1828 0.0282

ALA 1828 LEU 1829 0.0248

LEU 1829 ALA 1830 0.0197

ALA 1830 GLN 1831 0.0073

GLN 1831 ASN 1832 0.0270

ASN 1832 ALA 1833 0.0163

ALA 1833 ASP 1834 0.0068

ASP 1834 SER 1835 0.0288

SER 1835 SER 1836 0.0212

SER 1836 ILE 1837 0.0154

ILE 1837 LYS 1838 0.0016

LYS 1838 ASP 1839 0.0235

ASP 1839 SER 1840 0.0161

SER 1840 GLU 1841 0.0273

GLU 1841 PHE 1842 0.0227

PHE 1842 ALA 1843 0.0254

ALA 1843 GLU 1844 0.0200

GLU 1844 GLN 1845 0.0257

GLN 1845 ASP 1846 0.0231

ASP 1846 GLY 1847 0.0244

GLY 1847 GLN 1848 0.0058

GLN 1848 LEU 1849 0.0253

LEU 1849 PHE 1850 0.0094

PHE 1850 VAL 1851 0.0184

VAL 1851 PRO 1852 0.0173

PRO 1852 ARG 1853 -0.0054

ARG 1853 ILE 1854 0.0171

ILE 1854 SER 1855 0.0056

SER 1855 CYS 1856 0.0125

CYS 1856 ASP 1857 0.0198

ASP 1857 ILE 1858 0.0021

ILE 1858 ALA 1859 0.0200

ALA 1859 ARG 1860 0.0165

ARG 1860 ASN 1861 0.0105

ASN 1861 GLU 1862 0.0106

GLU 1862 ASP 1863 0.0155

ASP 1863 LEU 1864 0.0207

LEU 1864 SER 1865 0.0014

SER 1865 SER 1866 0.0189

SER 1866 ASP 1867 0.0200

ASP 1867 SER 1868 0.0081

SER 1868 ASN 1869 0.0026

ASN 1869 SER 1870 0.0007

SER 1870 PRO 1871 0.0021

PRO 1871 ALA 1872 0.0002

ALA 1872 GLN 1873 0.0016

GLN 1873 MET 1874 0.0009

MET 1874 GLU 1875 0.0007

GLU 1875 PRO 1876 0.0002

PRO 1876 PHE 1877 0.0022

PHE 1877 HIS 1878 0.0006

HIS 1878 GLN 1879 0.0024

GLN 1879 PRO 1880 0.0012

PRO 1880 GLY 1881 0.0019

GLY 1881 LYS 1882 0.0003

LYS 1882 LEU 1883 0.0024

LEU 1883 LEU 1884 0.0014

LEU 1884 GLN 1885 0.0131

GLN 1885 MET 1886 0.0023

MET 1886 GLY 1887 0.0003

GLY 1887 ILE 1888 0.0018

ILE 1888 LYS 1889 0.0007

LYS 1889 THR 1890 0.0021

THR 1890 PRO 1891 0.0025

PRO 1891 GLY 1892 0.0025

GLY 1892 LEU 1893 0.0024

LEU 1893 ILE 1894 0.0001

ILE 1894 ASP 1895 0.0025

ASP 1895 THR 1896 0.0023

THR 1896 LEU 1897 0.0006

LEU 1897 GLN 1898 0.0025

GLN 1898 PHE 1899 0.0021

PHE 1899 SER 1900 0.0019

SER 1900 LYS 1901 0.0041

LYS 1901 THR 1902 0.0016

THR 1902 ASP 1903 0.0019

ASP 1903 ALA 1904 0.0001

ALA 1904 THR 1905 0.0017

THR 1905 ASP 1906 0.0002

ASP 1906 ASN 1907 0.0018

ASN 1907 LEU 1908 0.0016

LEU 1908 PRO 1909 0.0018

PRO 1909 ASN 1910 0.0007

ASN 1910 ASP 1911 0.0017

ASP 1911 TYR 1912 0.0019

TYR 1912 ILE 1913 0.0013

ILE 1913 GLU 1914 0.0019

GLU 1914 ILE 1915 0.0015

ILE 1915 GLU 1916 0.0018

GLU 1916 PRO 1917 0.0084

PRO 1917 LYS 1918 0.0012

LYS 1918 ALA 1919 0.0015

ALA 1919 PHE 1920 0.0007

PHE 1920 GLY 1921 0.0018

GLY 1921 LEU 1922 0.0006

LEU 1922 ASN 1923 0.0012

ASN 1923 PHE 1924 0.0008

PHE 1924 ARG 1925 0.0011

ARG 1925 ASP 1926 0.0018

ASP 1926 VAL 1927 0.0015

VAL 1927 MET 1928 0.0011

MET 1928 VAL 1929 0.0015

VAL 1929 ALA 1930 0.0015

ALA 1930 MET 1931 0.0010

MET 1931 GLY 1932 0.0012

GLY 1932 GLN 1933 -0.0121

GLN 1933 LEU 1934 0.0015

LEU 1934 GLU 1935 0.0010

GLU 1935 GLU 1936 0.0008

GLU 1936 SER 1937 0.0015

SER 1937 ILE 1938 0.0002

ILE 1938 MET 1939 0.0006

MET 1939 GLY 1940 0.0003

GLY 1940 PHE 1941 0.0011

PHE 1941 GLU 1942 0.0003

GLU 1942 CYS 1943 0.0009

CYS 1943 ALA 1944 0.0003

ALA 1944 GLY 1945 0.0015

GLY 1945 VAL 1946 0.0014

VAL 1946 VAL 1947 0.0014

VAL 1947 ARG 1948 0.0011

ARG 1948 ARG 1949 0.0085

ARG 1949 VAL 1950 0.0016

VAL 1950 GLY 1951 0.0010

GLY 1951 PRO 1952 0.0012

PRO 1952 SER 1953 0.0017

SER 1953 SER 1954 0.0018

SER 1954 ALA 1955 0.0001

ALA 1955 GLY 1956 0.0017

GLY 1956 HIS 1957 0.0019

HIS 1957 ASN 1958 0.0009

ASN 1958 ILE 1959 0.0012

ILE 1959 LYS 1960 0.0015

LYS 1960 VAL 1961 0.0014

VAL 1961 GLY 1962 0.0014

GLY 1962 ASP 1963 0.0018

ASP 1963 ARG 1964 0.0015

ARG 1964 VAL 1965 -0.0008

VAL 1965 CYS 1966 0.0008

CYS 1966 ALA 1967 0.0004

ALA 1967 LEU 1968 0.0005

LEU 1968 LEU 1969 0.0008

LEU 1969 GLY 1970 0.0006

GLY 1970 GLY 1971 0.0017

GLY 1971 GLN 1972 0.0018

GLN 1972 TRP 1973 0.0017

TRP 1973 THR 1974 0.0017

THR 1974 ASN 1975 0.0008

ASN 1975 THR 1976 0.0018

THR 1976 VAL 1977 0.0017

VAL 1977 ARG 1978 0.0019

ARG 1978 VAL 1979 0.0019

VAL 1979 HIS 1980 0.0018

HIS 1980 TRP 1981 0.0041

TRP 1981 HIS 1982 0.0018

HIS 1982 SER 1983 0.0016

SER 1983 VAL 1984 0.0005

VAL 1984 ALA 1985 0.0004

ALA 1985 PRO 1986 0.0005

PRO 1986 ILE 1987 0.0015

ILE 1987 PRO 1988 0.0004

PRO 1988 GLN 1989 0.0012

GLN 1989 ALA 1990 0.0015

ALA 1990 MET 1991 0.0002

MET 1991 ASP 1992 0.0012

ASP 1992 TRP 1993 0.0002

TRP 1993 GLU 1994 0.0014

GLU 1994 THR 1995 0.0015

THR 1995 ALA 1996 0.0015

ALA 1996 ALA 1997 0.0034

ALA 1997 SER 1998 0.0011

SER 1998 ILE 1999 0.0012

ILE 1999 PRO 2000 0.0008

PRO 2000 ILE 2001 0.0002

ILE 2001 VAL 2002 0.0011

VAL 2002 PHE 2003 0.0005

PHE 2003 VAL 2004 0.0009

VAL 2004 THR 2005 0.0006

THR 2005 ALA 2006 0.0006

ALA 2006 TYR 2007 0.0010

TYR 2007 ILE 2008 0.0003

ILE 2008 SER 2009 0.0012

SER 2009 LEU 2010 0.0004

LEU 2010 VAL 2011 0.0009

VAL 2011 LYS 2012 0.0008

LYS 2012 ILE 2013 -0.0141

ILE 2013 ALA 2014 0.0009

ALA 2014 ARG 2015 0.0002

ARG 2015 MET 2016 0.0008

MET 2016 GLN 2017 0.0003

GLN 2017 ALA 2018 0.0004

ALA 2018 GLY 2019 0.0011

GLY 2019 GLU 2020 -0.0001

GLU 2020 THR 2021 0.0007

THR 2021 VAL 2022 0.0007

VAL 2022 LEU 2023 0.0004

LEU 2023 ILE 2024 0.0009

ILE 2024 HIS 2025 0.0004

HIS 2025 ALA 2026 0.0011

ALA 2026 ALA 2027 -0.0000

ALA 2027 SER 2028 0.0009

SER 2028 GLY 2029 0.0076

GLY 2029 GLY 2030 0.0011

GLY 2030 VAL 2031 0.0010

VAL 2031 GLY 2032 0.0013

GLY 2032 GLN 2033 0.0000

GLN 2033 ALA 2034 0.0011

ALA 2034 ALA 2035 0.0012

ALA 2035 ILE 2036 0.0006

ILE 2036 ILE 2037 0.0005

ILE 2037 LEU 2038 0.0010

LEU 2038 ALA 2039 0.0009

ALA 2039 LYS 2040 0.0003

LYS 2040 HIS 2041 0.0009

HIS 2041 VAL 2042 0.0010

VAL 2042 GLY 2043 0.0010

GLY 2043 ALA 2044 0.0002

ALA 2044 GLU 2045 -0.0060

GLU 2045 ILE 2046 0.0008

ILE 2046 PHE 2047 0.0002

PHE 2047 ALA 2048 0.0010

ALA 2048 THR 2049 0.0003

THR 2049 VAL 2050 0.0013

VAL 2050 GLY 2051 0.0004

GLY 2051 THR 2052 0.0009

THR 2052 ASP 2053 0.0003

ASP 2053 GLU 2054 0.0008

GLU 2054 LYS 2055 0.0011

LYS 2055 ARG 2056 0.0011

ARG 2056 ASP 2057 0.0005

ASP 2057 LEU 2058 0.0008

LEU 2058 LEU 2059 0.0012

LEU 2059 ILE 2060 0.0006

ILE 2060 LYS 2061 -0.0017

LYS 2061 GLU 2062 0.0011

GLU 2062 TYR 2063 0.0011

TYR 2063 LYS 2064 0.0010

LYS 2064 ILE 2065 0.0003

ILE 2065 PRO 2066 0.0010

PRO 2066 ASP 2067 0.0006

ASP 2067 ASP 2068 0.0008

ASP 2068 HIS 2069 0.0011

HIS 2069 ILE 2070 0.0008

ILE 2070 PHE 2071 -0.0000

PHE 2071 SER 2072 0.0003

SER 2072 SER 2073 0.0008

SER 2073 ARG 2074 0.0003

ARG 2074 ASN 2075 0.0009

ASN 2075 ALA 2076 0.0011

ALA 2076 LEU 2077 0.0042

LEU 2077 PHE 2078 0.0001

PHE 2078 ALA 2079 0.0007

ALA 2079 LYS 2080 0.0007

LYS 2080 SER 2081 0.0002

SER 2081 ILE 2082 0.0005

ILE 2082 ARG 2083 0.0006

ARG 2083 GLN 2084 0.0007

GLN 2084 ARG 2085 0.0003

ARG 2085 THR 2086 0.0006

THR 2086 ASN 2087 0.0006

ASN 2087 GLY 2088 0.0004

GLY 2088 LYS 2089 0.0005

LYS 2089 GLY 2090 0.0006

GLY 2090 VAL 2091 0.0006

VAL 2091 ASP 2092 0.0004

ASP 2092 VAL 2093 0.0033

VAL 2093 VAL 2094 0.0005

VAL 2094 LEU 2095 0.0006

LEU 2095 ASN 2096 0.0001

ASN 2096 CYS 2097 0.0006

CYS 2097 LEU 2098 0.0001

LEU 2098 ALA 2099 0.0002

ALA 2099 GLY 2100 0.0002

GLY 2100 GLY 2101 0.0008

GLY 2101 LEU 2102 0.0001

LEU 2102 LEU 2103 0.0007

LEU 2103 GLN 2104 0.0007

GLN 2104 GLU 2105 0.0007

GLU 2105 SER 2106 0.0000

SER 2106 PHE 2107 0.0006

PHE 2107 ASP 2108 0.0005

ASP 2108 CYS 2109 -0.0033

CYS 2109 LEU 2110 0.0004

LEU 2110 ALA 2111 0.0003

ALA 2111 ASP 2112 0.0007

ASP 2112 PHE 2113 0.0006

PHE 2113 GLY 2114 0.0008

GLY 2114 ARG 2115 0.0005

ARG 2115 PHE 2116 0.0004

PHE 2116 ILE 2117 0.0006

ILE 2117 GLU 2118 0.0003

GLU 2118 ILE 2119 0.0006

ILE 2119 GLY 2120 0.0001

GLY 2120 LYS 2121 0.0005

LYS 2121 ARG 2122 0.0001

ARG 2122 ASP 2123 0.0005

ASP 2123 ILE 2124 0.0007

ILE 2124 GLU 2125 0.0032

GLU 2125 LEU 2126 0.0001

LEU 2126 ASN 2127 0.0006

ASN 2127 HIS 2128 0.0004

HIS 2128 CYS 2129 0.0007

CYS 2129 LEU 2130 0.0002

LEU 2130 ASN 2131 0.0005

ASN 2131 MET 2132 0.0004

MET 2132 GLY 2133 0.0006

GLY 2133 MET 2134 0.0002

MET 2134 PHE 2135 0.0005

PHE 2135 ALA 2136 0.0005

ALA 2136 ARG 2137 0.0003

ARG 2137 SER 2138 0.0003

SER 2138 ALA 2139 0.0004

ALA 2139 THR 2140 0.0006

THR 2140 PHE 2141 0.0119

PHE 2141 THR 2142 0.0010

THR 2142 ALA 2143 0.0009

ALA 2143 VAL 2144 0.0007

VAL 2144 ASP 2145 0.0009

ASP 2145 LEU 2146 0.0009

LEU 2146 ILE 2147 0.0005

ILE 2147 ALA 2148 0.0010

ALA 2148 ILE 2149 0.0002

ILE 2149 GLY 2150 0.0011

GLY 2150 ARG 2151 0.0002

ARG 2151 ASP 2152 0.0010

ASP 2152 ARG 2153 -0.0001

ARG 2153 SER 2154 0.0008

SER 2154 TYR 2155 0.0007

TYR 2155 MET 2156 0.0009

MET 2156 PHE 2157 -0.0127

PHE 2157 ALA 2158 0.0010

ALA 2158 GLU 2159 0.0012

GLU 2159 ALA 2160 0.0013

ALA 2160 LEU 2161 0.0015

LEU 2161 PRO 2162 0.0006

PRO 2162 LYS 2163 0.0015

LYS 2163 ILE 2164 0.0015

ILE 2164 MET 2165 0.0010

MET 2165 THR 2166 0.0006

THR 2166 LEU 2167 0.0014

LEU 2167 LEU 2168 0.0016

LEU 2168 GLN 2169 0.0008

GLN 2169 GLU 2170 0.0012

GLU 2170 LYS 2171 0.0016

LYS 2171 ALA 2172 0.0014

ALA 2172 ILE 2173 -0.0004

ILE 2173 ARG 2174 0.0018

ARG 2174 PRO 2175 0.0007

PRO 2175 VAL 2176 0.0007

VAL 2176 THR 2177 0.0017

THR 2177 PRO 2178 0.0018

PRO 2178 ILE 2179 0.0016

ILE 2179 SER 2180 0.0011

SER 2180 ILE 2181 0.0018

ILE 2181 TYR 2182 0.0006

TYR 2182 LYS 2183 0.0015

LYS 2183 ILE 2184 0.0009

ILE 2184 GLY 2185 0.0015

GLY 2185 ASP 2186 0.0017

ASP 2186 ILE 2187 0.0013

ILE 2187 GLU 2188 0.0005

GLU 2188 THR 2189 0.0132

THR 2189 ALA 2190 0.0014

ALA 2190 PHE 2191 0.0002

PHE 2191 ARG 2192 0.0015

ARG 2192 LEU 2193 0.0004

LEU 2193 MET 2194 0.0015

MET 2194 GLN 2195 0.0001

GLN 2195 ALA 2196 0.0014

ALA 2196 GLY 2197 0.0009

GLY 2197 LYS 2198 0.0008

LYS 2198 HIS 2199 0.0009

HIS 2199 MET 2200 0.0006

MET 2200 GLY 2201 0.0014

GLY 2201 LYS 2202 0.0013

LYS 2202 ILE 2203 0.0015

ILE 2203 VAL 2204 0.0013

VAL 2204 ILE 2205 0.0001

ILE 2205 THR 2206 0.0014

THR 2206 ALA 2207 0.0032

ALA 2207 PRO 2208 0.0018

PRO 2208 GLU 2209 0.0031

GLU 2209 ASP 2210 0.0024

ASP 2210 ALA 2211 0.0011

ALA 2211 MET 2212 0.0008

MET 2212 VAL 2213 0.0010

VAL 2213 PRO 2214 0.0004

PRO 2214 VAL 2215 0.0031

VAL 2215 ILE 2216 0.0010

ILE 2216 THR 2217 0.0031

THR 2217 ARG 2218 0.0021

ARG 2218 PRO 2219 0.0028

PRO 2219 PRO 2220 0.0027

PRO 2220 LYS 2221 0.0707

LYS 2221 LEU 2222 0.0039

LEU 2222 GLN 2223 0.0154

GLN 2223 LEU 2224 0.0050

LEU 2224 ARG 2225 0.0139

ARG 2225 PRO 2226 0.0145

PRO 2226 ASP 2227 0.0056

ASP 2227 ALA 2228 0.0093

ALA 2228 SER 2229 0.0127

SER 2229 TYR 2230 0.0153

TYR 2230 LEU 2231 0.0073

LEU 2231 ILE 2232 0.0148

ILE 2232 VAL 2233 0.0067

VAL 2233 GLY 2234 0.0135

GLY 2234 GLY 2235 0.0057

GLY 2235 LEU 2236 0.0150

LEU 2236 GLY 2237 -0.0014

GLY 2237 GLY 2238 0.0034

GLY 2238 ILE 2239 0.0145

ILE 2239 GLY 2240 0.0119

GLY 2240 ARG 2241 0.0059

ARG 2241 SER 2242 0.0087

SER 2242 LEU 2243 0.0108

LEU 2243 CYS 2244 0.0146

CYS 2244 LYS 2245 0.0002

LYS 2245 ASN 2246 0.0144

ASN 2246 PHE 2247 0.0091

PHE 2247 VAL 2248 0.0114

VAL 2248 GLU 2249 0.0034

GLU 2249 ASN 2250 0.0124

ASN 2250 GLY 2251 0.0135

GLY 2251 ALA 2252 0.0031

ALA 2252 ARG 2253 0.0243

ARG 2253 SER 2254 0.0015

SER 2254 LEU 2255 0.0138

LEU 2255 VAL 2256 0.0022

VAL 2256 LEU 2257 0.0158

LEU 2257 LEU 2258 0.0026

LEU 2258 SER 2259 0.0152

SER 2259 ARG 2260 0.0064

ARG 2260 ASN 2261 0.0113

ASN 2261 ALA 2262 0.0110

ALA 2262 ASN 2263 0.0157

ASN 2263 VAL 2264 0.0078

VAL 2264 SER 2265 0.0094

SER 2265 GLN 2266 0.0119

GLN 2266 GLN 2267 0.0145

GLN 2267 SER 2268 0.0155

SER 2268 GLY 2269 0.0302

GLY 2269 GLU 2270 0.0023

GLU 2270 PHE 2271 0.0148

PHE 2271 LEU 2272 0.0116

LEU 2272 ASP 2273 0.0070

ASP 2273 GLU 2274 0.0108

GLU 2274 LEU 2275 0.0103

LEU 2275 ARG 2276 0.0162

ARG 2276 SER 2277 0.0002

SER 2277 THR 2278 0.0164

THR 2278 GLY 2279 0.0113

GLY 2279 CYS 2280 0.0058

CYS 2280 ILE 2281 0.0034

ILE 2281 VAL 2282 0.0135

VAL 2282 GLY 2283 0.0011

GLY 2283 VAL 2284 0.0150

VAL 2284 VAL 2285 -0.0111

VAL 2285 ASP 2286 0.0103

ASP 2286 CYS 2287 0.0121

CYS 2287 ASP 2288 0.0136

ASP 2288 ILE 2289 0.0170

ILE 2289 SER 2290 0.0073

SER 2290 SER 2291 0.0110

SER 2291 LYS 2292 0.0158

LYS 2292 THR 2293 0.0159

THR 2293 GLN 2294 0.0036

GLN 2294 VAL 2295 0.0129

VAL 2295 GLU 2296 0.0121

GLU 2296 ALA 2297 0.0165

ALA 2297 THR 2298 0.0010

THR 2298 MET 2299 0.0168

MET 2299 LEU 2300 0.0134

LEU 2300 ARG 2301 -0.0046

ARG 2301 LEU 2302 0.0049

LEU 2302 LYS 2303 0.0152

LYS 2303 LYS 2304 0.0163

LYS 2304 ASP 2305 0.0071

ASP 2305 MET 2306 0.0095

MET 2306 LEU 2307 0.0134

LEU 2307 PRO 2308 0.0123

PRO 2308 ILE 2309 0.0162

ILE 2309 ARG 2310 0.0119

ARG 2310 GLY 2311 0.0160

GLY 2311 ILE 2312 0.0138

ILE 2312 VAL 2313 0.0141

VAL 2313 HIS 2314 0.0086

HIS 2314 ALA 2315 0.0127

ALA 2315 GLY 2316 0.0057

GLY 2316 MET 2317 0.0733

MET 2317 VAL 2318 0.0176

VAL 2318 LEU 2319 0.0216

LEU 2319 GLN 2320 0.0119

GLN 2320 ASP 2321 0.0201

ASP 2321 SER 2322 0.0129

SER 2322 VAL 2323 0.0220

VAL 2323 PHE 2324 0.0098

PHE 2324 GLU 2325 0.0141

GLU 2325 ARG 2326 0.0223

ARG 2326 MET 2327 0.0223

MET 2327 SER 2328 0.0093

SER 2328 LEU 2329 0.0182

LEU 2329 ASP 2330 0.0193

ASP 2330 ASP 2331 0.0036

ASP 2331 TYR 2332 0.0222

TYR 2332 ASN 2333 0.0339

ASN 2333 THR 2334 0.0107

THR 2334 ALA 2335 0.0088

ALA 2335 ILE 2336 0.0176

ILE 2336 ARG 2337 0.0181

ARG 2337 PRO 2338 0.0050

PRO 2338 LYS 2339 0.0184

LYS 2339 VAL 2340 0.0043

VAL 2340 GLN 2341 0.0133

GLN 2341 GLY 2342 0.0078

GLY 2342 SER 2343 0.0160

SER 2343 TRP 2344 0.0054

TRP 2344 ASN 2345 0.0196

ASN 2345 LEU 2346 0.0032

LEU 2346 HIS 2347 0.0199

HIS 2347 SER 2348 0.0051

SER 2348 GLY 2349 -0.0017

GLY 2349 LEU 2350 0.0061

LEU 2350 SER 2351 0.0138

SER 2351 ASP 2352 0.0173

ASP 2352 CYS 2353 0.0009

CYS 2353 ASP 2354 0.0093

ASP 2354 LEU 2355 0.0126

LEU 2355 ASP 2356 0.0024

ASP 2356 PHE 2357 0.0172

PHE 2357 PHE 2358 0.0095

PHE 2358 ILE 2359 0.0149

ILE 2359 MET 2360 0.0132

MET 2360 LEU 2361 0.0130

LEU 2361 SER 2362 0.0125

SER 2362 SER 2363 0.0160

SER 2363 LEU 2364 0.0152

LEU 2364 ALA 2365 0.0088

ALA 2365 GLY 2366 0.0126

GLY 2366 VAL 2367 0.0162

VAL 2367 SER 2368 0.0197

SER 2368 GLY 2369 0.0086

GLY 2369 SER 2370 0.0221

SER 2370 ALA 2371 0.0178

ALA 2371 SER 2372 0.0142

SER 2372 GLN 2373 0.0227

GLN 2373 ALA 2374 0.0097

ALA 2374 ASN 2375 0.0200

ASN 2375 TYR 2376 0.0049

TYR 2376 THR 2377 0.0213

THR 2377 ALA 2378 0.0053

ALA 2378 GLY 2379 0.0215

GLY 2379 GLY 2380 0.0047

GLY 2380 ALA 2381 0.0122

ALA 2381 TYR 2382 0.0118

TYR 2382 GLN 2383 0.0090

GLN 2383 ASP 2384 0.0153

ASP 2384 ALA 2385 0.0060

ALA 2385 LEU 2386 0.0191

LEU 2386 ALA 2387 0.0029

ALA 2387 LYS 2388 0.0188

LYS 2388 TYR 2389 0.0043

TYR 2389 ARG 2390 0.0164

ARG 2390 ARG 2391 0.0101

ARG 2391 ALA 2392 0.0102

ALA 2392 GLN 2393 0.0157

GLN 2393 GLY 2394 0.0050

GLY 2394 LEU 2395 0.0193

LEU 2395 SER 2396 0.0060

SER 2396 ALA 2397 0.0325

ALA 2397 VAL 2398 0.0107

VAL 2398 SER 2399 0.0185

SER 2399 ILE 2400 0.0058

ILE 2400 ASP 2401 0.0184

ASP 2401 LEU 2402 0.0106

LEU 2402 GLY 2403 0.0140

GLY 2403 MET 2404 0.0162

MET 2404 VAL 2405 0.0143

VAL 2405 GLN 2406 0.0076

GLN 2406 SER 2407 0.0178

SER 2407 VAL 2408 0.0049

VAL 2408 GLY 2409 0.0014

GLY 2409 TYR 2410 0.0139

TYR 2410 VAL 2411 0.0104

VAL 2411 ALA 2412 0.0084

ALA 2412 GLU 2413 0.0040

GLU 2413 THR 2414 0.0175

THR 2414 LYS 2415 0.0122

LYS 2415 GLY 2416 0.0196

GLY 2416 VAL 2417 0.0151

VAL 2417 ALA 2418 0.0067

ALA 2418 GLU 2419 0.0167

GLU 2419 ARG 2420 0.0045

ARG 2420 LEU 2421 0.0194

LEU 2421 VAL 2422 0.0027

VAL 2422 ARG 2423 0.0187

ARG 2423 MET 2424 0.0062

MET 2424 GLY 2425 0.0137

GLY 2425 TYR 2426 0.0194

TYR 2426 SER 2427 0.0070

SER 2427 PRO 2428 0.0189

PRO 2428 ILE 2429 0.0409

ILE 2429 SER 2430 0.0117

SER 2430 GLU 2431 0.0138

GLU 2431 MET 2432 0.0106

MET 2432 GLU 2433 0.0139

GLU 2433 VAL 2434 0.0023

VAL 2434 LEU 2435 0.0152

LEU 2435 LYS 2436 0.0128

LYS 2436 ILE 2437 0.0059

ILE 2437 VAL 2438 0.0106

VAL 2438 GLU 2439 0.0101

GLU 2439 HIS 2440 0.0162

HIS 2440 ALA 2441 0.0002

ALA 2441 ILE 2442 0.0161

ILE 2442 THR 2443 0.0083

THR 2443 ASN 2444 0.0154

ASN 2444 PRO 2445 -0.0146

PRO 2445 PRO 2446 0.0173

PRO 2446 PRO 2447 0.0178

PRO 2447 GLU 2448 0.0088

GLU 2448 ALA 2449 0.0068

ALA 2449 SER 2450 0.0179

SER 2450 SER 2451 0.0048

SER 2451 ALA 2452 0.0156

ALA 2452 GLN 2453 0.0184

GLN 2453 ILE 2454 0.0042

ILE 2454 ILE 2455 0.0187

ILE 2455 THR 2456 0.0100

THR 2456 GLY 2457 0.0166

GLY 2457 ILE 2458 0.0189

ILE 2458 SER 2459 0.0070

SER 2459 THR 2460 0.0150

THR 2460 LYS 2461 0.0013

LYS 2461 PRO 2462 0.0225

PRO 2462 GLY 2463 0.0200

GLY 2463 ARG 2464 0.0140

ARG 2464 HIS 2465 0.0114

HIS 2465 TRP 2466 0.0225

TRP 2466 THR 2467 0.0214

THR 2467 GLU 2468 0.0189

GLU 2468 SER 2469 0.0173

SER 2469 SER 2470 0.0044

SER 2470 TRP 2471 0.0224

TRP 2471 LEU 2472 0.0065

LEU 2472 GLN 2473 0.0195

GLN 2473 ASP 2474 0.0117

ASP 2474 ALA 2475 0.0227

ALA 2475 ARG 2476 0.0228

ARG 2476 PHE 2477 -0.0026

PHE 2477 ALA 2478 0.0248

ALA 2478 THR 2479 0.0178

THR 2479 LEU 2480 0.0220

LEU 2480 ARG 2481 0.0274

ARG 2481 GLU 2482 0.0197

GLU 2482 ARG 2483 0.0190

ARG 2483 ALA 2484 0.0267

ALA 2484 ARG 2485 0.0263

ARG 2485 ASP 2486 0.0179

ASP 2486 VAL 2487 0.0217

VAL 2487 LYS 2488 0.0275

LYS 2488 GLU 2489 0.0246

GLU 2489 LEU 2490 0.0182

LEU 2490 SER 2491 0.0231

SER 2491 ASN 2492 0.0264

ASN 2492 SER 2493 0.0452

SER 2493 GLN 2494 0.0125

GLN 2494 ASN 989 0.0804

ASN 989 LYS 990 -0.0003

LYS 990 ALA 991 0.0001

ALA 991 HIS 992 -0.0001

HIS 992 ARG 993 0.0002

ARG 993 GLN 994 -0.0002

GLN 994 ARG 995 0.0003

ARG 995 VAL 996 -0.0000

VAL 996 HIS 997 0.0002

HIS 997 PRO 998 0.0001

PRO 998 PRO 999 0.0001

PRO 999 HIS 1000 -0.0001

HIS 1000 ASP 1001 0.0001

ASP 1001 LEU 1002 -0.0001

LEU 1002 LEU 1003 -0.0001

LEU 1003 GLY 1004 0.0001

GLY 1004 SER 1005 -0.0171

SER 1005 LEU 1006 0.0001

LEU 1006 ILE 1007 0.0000

ILE 1007 VAL 1008 0.0001

VAL 1008 GLY 1009 0.0000

GLY 1009 ARG 1010 0.0001

ARG 1010 ASP 1011 -0.0000

ASP 1011 LEU 1012 0.0002

LEU 1012 ARG 1013 0.0001

ARG 1013 GLU 1014 0.0001

GLU 1014 PRO 1015 0.0000

PRO 1015 THR 1016 0.0001

THR 1016 TRP 1017 0.0001

TRP 1017 ARG 1018 -0.0000

ARG 1018 HIS 1019 -0.0000

HIS 1019 PHE 1020 0.0000

PHE 1020 ILE 1021 0.0171

ILE 1021 ARG 1022 0.0001

ARG 1022 VAL 1023 0.0004

VAL 1023 GLN 1024 0.0002

GLN 1024 ASP 1025 0.0002

ASP 1025 ILE 1026 0.0004

ILE 1026 PRO 1027 0.0001

PRO 1027 TRP 1028 0.0002

TRP 1028 ILE 1029 0.0002

ILE 1029 ARG 1030 -0.0000

ARG 1030 ASP 1031 0.0004

ASP 1031 HIS 1032 0.0001

HIS 1032 VAL 1033 0.0002

VAL 1033 VAL 1034 0.0004

VAL 1034 GLN 1035 0.0002

GLN 1035 SER 1036 0.0001

SER 1036 ALA 1037 0.0174

ALA 1037 LEU 1038 0.0001

LEU 1038 VAL 1039 0.0001

VAL 1039 TYR 1040 0.0001

TYR 1040 PRO 1041 0.0002

PRO 1041 GLY 1042 0.0002

GLY 1042 ALA 1043 0.0000

ALA 1043 GLY 1044 0.0001

GLY 1044 PHE 1045 0.0001

PHE 1045 ILE 1046 0.0001

ILE 1046 CYS 1047 0.0003

CYS 1047 MET 1048 0.0001

MET 1048 ALA 1049 -0.0000

ALA 1049 MET 1050 0.0003

MET 1050 GLU 1051 0.0001

GLU 1051 ALA 1052 0.0003

ALA 1052 MET 1053 0.0123

MET 1053 VAL 1054 0.0002

VAL 1054 GLN 1055 0.0003

GLN 1055 LEU 1056 0.0000

LEU 1056 HIS 1057 0.0001

HIS 1057 GLU 1058 -0.0001

GLU 1058 LEU 1059 -0.0001

LEU 1059 ARG 1060 0.0001

ARG 1060 ASP 1061 0.0001

ASP 1061 SER 1062 0.0002

SER 1062 GLN 1063 -0.0000

GLN 1063 SER 1064 0.0001

SER 1064 ARG 1065 -0.0000

ARG 1065 LYS 1066 0.0000

LYS 1066 VAL 1067 0.0001

VAL 1067 ALA 1068 0.0002

ALA 1068 GLY 1069 0.0067

GLY 1069 TYR 1070 0.0001

TYR 1070 ARG 1071 0.0001

ARG 1071 LEU 1072 0.0004

LEU 1072 ALA 1073 0.0001

ALA 1073 GLU 1074 0.0001

GLU 1074 VAL 1075 -0.0000

VAL 1075 ASP 1076 0.0003

ASP 1076 ILE 1077 -0.0001

ILE 1077 LEU 1078 0.0002

LEU 1078 ARG 1079 0.0001

ARG 1079 ALA 1080 -0.0001

ALA 1080 MET 1081 0.0000

MET 1081 LEU 1082 -0.0002

LEU 1082 ILE 1083 0.0002

ILE 1083 PRO 1084 -0.0001

PRO 1084 ASP 1085 -0.0074

ASP 1085 THR 1086 -0.0000

THR 1086 SER 1087 -0.0000

SER 1087 GLU 1088 0.0000

GLU 1088 GLY 1089 0.0001

GLY 1089 LEU 1090 0.0001

LEU 1090 GLU 1091 0.0000

GLU 1091 ALA 1092 0.0001

ALA 1092 HIS 1093 -0.0000

HIS 1093 ILE 1094 0.0001

ILE 1094 SER 1095 -0.0002

SER 1095 LEU 1096 0.0001

LEU 1096 ARG 1097 0.0001

ARG 1097 PRO 1098 -0.0000

PRO 1098 CYS 1099 0.0001

CYS 1099 SER 1100 0.0000

SER 1100 THR 1101 -0.0105

THR 1101 LYS 1102 -0.0000

LYS 1102 LEU 1103 0.0003

LEU 1103 LEU 1104 0.0002

LEU 1104 LEU 1105 -0.0001

LEU 1105 THR 1106 -0.0001

THR 1106 ASN 1107 0.0001

ASN 1107 GLU 1108 0.0001

GLU 1108 TRP 1109 -0.0000

TRP 1109 TYR 1110 0.0000

TYR 1110 ASP 1111 0.0000

ASP 1111 PHE 1112 0.0001

PHE 1112 CYS 1113 0.0002

CYS 1113 VAL 1114 0.0002

VAL 1114 SER 1115 -0.0000

SER 1115 SER 1116 0.0000

SER 1116 VAL 1117 0.0038

VAL 1117 GLY 1118 -0.0001

GLY 1118 ASP 1119 0.0001

ASP 1119 ASP 1120 -0.0001

ASP 1120 ASP 1121 0.0001

ASP 1121 LYS 1122 0.0001

LYS 1122 PHE 1123 0.0001

PHE 1123 VAL 1124 -0.0001

VAL 1124 ASP 1125 0.0002

ASP 1125 HIS 1126 -0.0000

HIS 1126 CYS 1127 0.0002

CYS 1127 ARG 1128 -0.0001

ARG 1128 GLY 1129 0.0002

GLY 1129 ARG 1130 0.0001

ARG 1130 ILE 1131 0.0000

ILE 1131 THR 1132 0.0001

THR 1132 ILE 1133 0.0064

ILE 1133 GLU 1134 0.0002

GLU 1134 PHE 1135 0.0003

PHE 1135 ASP 1136 0.0004

ASP 1136 THR 1137 0.0000

THR 1137 SER 1138 0.0003

SER 1138 GLY 1139 0.0002

GLY 1139 SER 1140 0.0005

SER 1140 ALA 1141 0.0005

ALA 1141 ASP 1142 0.0004

ASP 1142 THR 1143 0.0006

THR 1143 PRO 1144 0.0007

PRO 1144 ARG 1145 -0.0000

ARG 1145 THR 1146 0.0006

THR 1146 SER 1147 0.0006

SER 1147 LEU 1148 0.0003

LEU 1148 ARG 1149 -0.0152

ARG 1149 GLU 1150 0.0011

GLU 1150 ARG 1151 0.0014

ARG 1151 SER 1152 0.0011

SER 1152 ARG 1153 0.0017

ARG 1153 SER 1154 0.0016

SER 1154 THR 1155 0.0014

THR 1155 GLY 1156 0.0001

GLY 1156 LEU 1157 0.0005

LEU 1157 MET 1158 0.0020

MET 1158 ARG 1159 -0.0001

ARG 1159 SER 1160 0.0019

SER 1160 VAL 1161 0.0015

VAL 1161 ASP 1162 0.0013

ASP 1162 PRO 1163 0.0020

PRO 1163 SER 1164 0.0002

SER 1164 ASN 1165 0.0381

ASN 1165 LEU 1166 0.0002

LEU 1166 TYR 1167 0.0006

TYR 1167 SER 1168 0.0000

SER 1168 PHE 1169 0.0007

PHE 1169 LEU 1170 0.0005

LEU 1170 ARG 1171 0.0001

ARG 1171 ALA 1172 0.0003

ALA 1172 GLN 1173 0.0003

GLN 1173 GLY 1174 0.0007

GLY 1174 ILE 1175 0.0002

ILE 1175 TYR 1176 0.0006

TYR 1176 HIS 1177 0.0003

HIS 1177 GLY 1178 0.0004

GLY 1178 PRO 1179 0.0005

PRO 1179 ILE 1180 0.0002

ILE 1180 PHE 1181 -0.0091

PHE 1181 GLN 1182 0.0006

GLN 1182 ASN 1183 0.0005

ASN 1183 LEU 1184 0.0007

LEU 1184 LYS 1185 0.0008

LYS 1185 THR 1186 0.0008

THR 1186 ILE 1187 0.0008

ILE 1187 SER 1188 0.0006

SER 1188 SER 1189 0.0007

SER 1189 ARG 1190 0.0007

ARG 1190 LYS 1191 0.0007

LYS 1191 ASP 1192 0.0002

ASP 1192 HIS 1193 0.0007

HIS 1193 SER 1194 0.0005

SER 1194 GLU 1195 0.0007

GLU 1195 SER 1196 0.0004

SER 1196 SER 1197 -0.0222

SER 1197 PHE 1198 0.0004

PHE 1198 VAL 1199 0.0005

VAL 1199 VAL 1200 0.0004

VAL 1200 ALA 1201 0.0000

ALA 1201 ASN 1202 0.0004

ASN 1202 THR 1203 0.0004

THR 1203 ALA 1204 0.0004

ALA 1204 SER 1205 -0.0001

SER 1205 VAL 1206 0.0003

VAL 1206 MET 1207 0.0004

MET 1207 PRO 1208 0.0004

PRO 1208 ASN 1209 0.0004

ASN 1209 GLY 1210 0.0004

GLY 1210 PHE 1211 0.0001

PHE 1211 GLN 1212 0.0001

GLN 1212 SER 1213 0.0049

SER 1213 PRO 1214 0.0002

PRO 1214 HIS 1215 0.0002

HIS 1215 VAL 1216 0.0004

VAL 1216 ILE 1217 0.0003

ILE 1217 HIS 1218 0.0001

HIS 1218 PRO 1219 0.0002

PRO 1219 THR 1220 0.0002

THR 1220 THR 1221 0.0001

THR 1221 LEU 1222 0.0002

LEU 1222 ASP 1223 0.0002

ASP 1223 SER 1224 0.0004

SER 1224 ILE 1225 0.0001

ILE 1225 PHE 1226 0.0002

PHE 1226 GLN 1227 -0.0001

GLN 1227 GLY 1228 0.0002

GLY 1228 ALA 1229 -0.0167

ALA 1229 TYR 1230 -0.0000

TYR 1230 THR 1231 0.0007

THR 1231 ALA 1232 0.0005

ALA 1232 LEU 1233 0.0007

LEU 1233 PRO 1234 0.0005

PRO 1234 GLY 1235 0.0002

GLY 1235 ALA 1236 0.0005

ALA 1236 GLY 1237 0.0008

GLY 1237 LEU 1238 -0.0000

LEU 1238 ASP 1239 0.0006

ASP 1239 GLN 1240 0.0007

GLN 1240 ASN 1241 0.0005

ASN 1241 THR 1242 0.0004

THR 1242 ALA 1243 0.0007

ALA 1243 MET 1244 -0.0001

MET 1244 ILE 1245 0.0183

ILE 1245 PRO 1246 0.0000

PRO 1246 ARG 1247 0.0003

ARG 1247 SER 1248 0.0001

SER 1248 ILE 1249 0.0005

ILE 1249 GLN 1250 0.0000

GLN 1250 GLU 1251 0.0005

GLU 1251 LEU 1252 0.0002

LEU 1252 TYR 1253 0.0004

TYR 1253 LEU 1254 0.0002

LEU 1254 SER 1255 0.0005

SER 1255 SER 1256 0.0004

SER 1256 ALA 1257 0.0004

ALA 1257 LEU 1258 -0.0000

LEU 1258 THR 1259 0.0002

THR 1259 SER 1260 0.0002

SER 1260 ASP 1261 0.0009

ASP 1261 VAL 1262 0.0000

VAL 1262 GLY 1263 0.0004

GLY 1263 GLN 1264 0.0003

GLN 1264 CYS 1265 0.0005

CYS 1265 LEU 1266 0.0003

LEU 1266 VAL 1267 0.0004

VAL 1267 SER 1268 0.0004

SER 1268 ASP 1269 0.0006

ASP 1269 THR 1270 0.0005

THR 1270 SER 1271 0.0006

SER 1271 LEU 1272 0.0004

LEU 1272 ILE 1273 0.0003

ILE 1273 ARG 1274 0.0004

ARG 1274 TYR 1275 0.0000

TYR 1275 ASP 1276 0.0004

ASP 1276 GLY 1277 0.0004

GLY 1277 GLN 1278 0.0005

GLN 1278 SER 1279 0.0003

SER 1279 PHE 1280 0.0006

PHE 1280 THR 1281 0.0002

THR 1281 VAL 1282 0.0005

VAL 1282 ASN 1283 0.0004

ASN 1283 VAL 1284 0.0003

VAL 1284 ASP 1285 0.0007

ASP 1285 VAL 1286 0.0004

VAL 1286 SER 1287 0.0005

SER 1287 SER 1288 0.0004

SER 1288 LYS 1289 0.0003

LYS 1289 ALA 1290 0.0005

ALA 1290 ASP 1291 0.0000

ASP 1291 SER 1292 0.0005

SER 1292 GLU 1293 0.0103

GLU 1293 HIS 1294 0.0002

HIS 1294 THR 1295 0.0002

THR 1295 PRO 1296 0.0005

PRO 1296 VAL 1297 0.0005

VAL 1297 LEU 1298 0.0005

LEU 1298 GLU 1299 0.0004

GLU 1299 ILE 1300 0.0006

ILE 1300 LYS 1301 0.0003

LYS 1301 GLY 1302 0.0006

GLY 1302 LEU 1303 0.0001

LEU 1303 ARG 1304 0.0006

ARG 1304 ASN 1305 0.0001

ASN 1305 GLN 1306 0.0004

GLN 1306 SER 1307 0.0003

SER 1307 VAL 1308 0.0006

VAL 1308 GLY 1309 -0.0477

GLY 1309 GLN 1310 0.0074

GLN 1310 MET 1311 0.0132

MET 1311 ALA 1312 0.0130

ALA 1312 PRO 1313 0.0018

PRO 1313 GLN 1314 0.0127

GLN 1314 PRO 1315 0.0128

PRO 1315 GLY 1316 0.0008

GLY 1316 ASP 1317 0.0126

ASP 1317 SER 1318 0.0130

SER 1318 SER 1319 0.0039

SER 1319 ASN 1320 0.0064

ASN 1320 ASN 1321 0.0131

ASN 1321 ASP 1322 0.0063

ASP 1322 LEU 1323 0.0066

LEU 1323 CYS 1324 0.0075

CYS 1324 PHE 1325 0.0252

PHE 1325 LYS 1326 0.0123

LYS 1326 LEU 1327 0.0095

LEU 1327 ASP 1328 0.0304

ASP 1328 TRP 1329 0.0091

TRP 1329 ALA 1330 0.0305

ALA 1330 PRO 1331 0.0179

PRO 1331 ASP 1332 0.0296

ASP 1332 ILE 1333 0.0265

ILE 1333 SER 1334 0.0193

SER 1334 SER 1335 0.0109

SER 1335 VAL 1336 0.0274

VAL 1336 LYS 1337 0.0210

LYS 1337 GLN 1338 0.0241

GLN 1338 GLU 1339 0.0249

GLU 1339 ARG 1340 0.0260

ARG 1340 LEU 1341 -0.0208

LEU 1341 LYS 1342 0.0367

LYS 1342 GLU 1343 0.0335

GLU 1343 LYS 1344 0.0166

LYS 1344 PHE 1345 0.0168

PHE 1345 GLY 1346 0.0343

GLY 1346 PHE 1347 0.0277

PHE 1347 PRO 1348 0.0310

PRO 1348 LEU 1349 0.0314

LEU 1349 ASP 1350 0.0186

ASP 1350 PRO 1351 0.0366

PRO 1351 THR 1352 0.0009

THR 1352 GLU 1353 0.0365

GLU 1353 ALA 1354 0.0200

ALA 1354 ASP 1355 0.0268

ASP 1355 ILE 1356 0.0111

ILE 1356 ILE 1357 0.0343

ILE 1357 MET 1358 0.0344

MET 1358 GLY 1359 0.0047

GLY 1359 LEU 1360 0.0338

LEU 1360 ARG 1361 0.0218

ARG 1361 GLN 1362 0.0341

GLN 1362 ALA 1363 0.0027

ALA 1363 CYS 1364 0.0365

CYS 1364 ILE 1365 0.0302

ILE 1365 HIS 1366 0.0147

HIS 1366 PHE 1367 0.0227

PHE 1367 ILE 1368 0.0247

ILE 1368 HIS 1369 0.0370

HIS 1369 ARG 1370 0.0017

ARG 1370 SER 1371 0.0353

SER 1371 LEU 1372 0.0209

LEU 1372 GLN 1373 0.0329

GLN 1373 SER 1374 0.0035

SER 1374 LEU 1375 0.0368

LEU 1375 THR 1376 0.0346

THR 1376 ALA 1377 0.0325

ALA 1377 PRO 1378 0.0131

PRO 1378 ASP 1379 0.0375

ASP 1379 ARG 1380 0.0049

ARG 1380 ASP 1381 0.0353

ASP 1381 GLN 1382 0.0203

GLN 1382 LEU 1383 0.0230

LEU 1383 ASP 1384 0.0373

ASP 1384 TRP 1385 0.0067

TRP 1385 HIS 1386 0.0364

HIS 1386 GLN 1387 0.0330

GLN 1387 LYS 1388 0.0227

LYS 1388 ARG 1389 0.0187

ARG 1389 PHE 1390 0.0326

PHE 1390 TYR 1391 0.0375

TYR 1391 ASP 1392 0.0032

ASP 1392 TRP 1393 0.0358

TRP 1393 MET 1394 0.0275

MET 1394 VAL 1395 0.0290

VAL 1395 LEU 1396 0.0094

LEU 1396 GLN 1397 0.0353

GLN 1397 ILE 1398 0.0364

ILE 1398 GLN 1399 0.0085

GLN 1399 LEU 1400 0.0303

LEU 1400 ALA 1401 0.0291

ALA 1401 GLU 1402 0.0344

GLU 1402 GLU 1403 0.0048

GLU 1403 ASP 1404 0.0376

ASP 1404 ARG 1405 0.0349

ARG 1405 LEU 1406 0.0145

LEU 1406 ALA 1407 0.0341

ALA 1407 PRO 1408 0.0276

PRO 1408 ASN 1409 0.0266

ASN 1409 SER 1410 0.0199

SER 1410 SER 1411 0.0375

SER 1411 ALA 1412 0.0304

ALA 1412 TRP 1413 0.0193

TRP 1413 LEU 1414 0.0334

LEU 1414 GLN 1415 0.0369

GLN 1415 CYS 1416 0.0255

CYS 1416 SER 1417 0.0146

SER 1417 SER 1418 0.0080

SER 1418 SER 1419 0.0374

SER 1419 ASP 1420 0.0083

ASP 1420 GLU 1421 0.0367

GLU 1421 GLN 1422 0.0103

GLN 1422 LYS 1423 0.0298

LYS 1423 LEU 1424 0.0199

LEU 1424 LEU 1425 0.0196

LEU 1425 GLU 1426 0.0284

GLU 1426 ASN 1427 0.0115

ASN 1427 VAL 1428 0.0351

VAL 1428 ARG 1429 0.0066

ARG 1429 ALA 1430 0.0379

ALA 1430 SER 1431 0.0042

SER 1431 SER 1432 0.0379

SER 1432 VAL 1433 0.0267

VAL 1433 ASN 1434 0.0235

ASN 1434 GLY 1435 0.0345

GLY 1435 GLN 1436 0.0033

GLN 1436 MET 1437 0.0369

MET 1437 VAL 1438 0.0273

VAL 1438 VAL 1439 0.0206

VAL 1439 HIS 1440 0.0161

HIS 1440 VAL 1441 0.0321

VAL 1441 GLY 1442 0.0301

GLY 1442 LYS 1443 0.0117

LYS 1443 SER 1444 0.0307

SER 1444 MET 1445 0.0136

MET 1445 LEU 1446 0.0334

LEU 1446 ALA 1447 0.0090

ALA 1447 ILE 1448 0.0289

ILE 1448 LEU 1449 0.0270

LEU 1449 ARG 1450 0.0101

ARG 1450 HIS 1451 0.0326

HIS 1451 GLU 1452 0.0198

GLU 1452 ILE 1453 0.0329

ILE 1453 ALA 1454 0.0317

ALA 1454 PRO 1455 0.0121

PRO 1455 LEU 1456 0.0380

LEU 1456 GLU 1457 0.0044

GLU 1457 LEU 1458 0.0351

LEU 1458 MET 1459 0.0187

MET 1459 LEU 1460 0.0232

LEU 1460 GLN 1461 0.0241

GLN 1461 ASP 1462 0.0382

ASP 1462 LYS 1463 0.0239

LYS 1463 LEU 1464 0.0184

LEU 1464 LEU 1465 0.0276

LEU 1465 TYR 1466 0.0379

TYR 1466 ARG 1467 0.0346

ARG 1467 TYR 1468 0.0185

TYR 1468 TYR 1469 0.0300

TYR 1469 THR 1470 0.0368

THR 1470 ASP 1471 0.0363

ASP 1471 ALA 1472 0.0268

ALA 1472 ILE 1473 0.0067

ILE 1473 LYS 1474 0.0152

LYS 1474 TRP 1475 0.0254

TRP 1475 ASP 1476 0.0367

ASP 1476 ARG 1477 0.0001

ARG 1477 SER 1478 0.0366

SER 1478 TYR 1479 0.0196

TYR 1479 GLN 1480 0.0279

GLN 1480 GLN 1481 0.0124

GLN 1481 ILE 1482 0.0266

ILE 1482 ASP 1483 0.0319

ASP 1483 GLN 1484 0.0053

GLN 1484 LEU 1485 0.0328

LEU 1485 VAL 1486 0.0127

VAL 1486 LYS 1487 0.0340

LYS 1487 LEU 1488 0.0037

LEU 1488 HIS 1489 0.0320

HIS 1489 ALA 1490 0.0146

ALA 1490 HIS 1491 0.0222

HIS 1491 LYS 1492 0.0209

LYS 1492 CYS 1493 0.0178

CYS 1493 PRO 1494 0.0104

PRO 1494 THR 1495 0.0302

THR 1495 ALA 1496 0.0335

ALA 1496 LYS 1497 0.0222

LYS 1497 ILE 1498 0.0335

ILE 1498 ILE 1499 0.0293

ILE 1499 GLU 1500 0.0326

GLU 1500 ILE 1501 0.0399

ILE 1501 GLY 1502 0.0201

GLY 1502 ALA 1503 0.0324

ALA 1503 GLY 1504 0.0161

GLY 1504 THR 1505 0.0294

THR 1505 GLY 1506 0.0232

GLY 1506 GLY 1507 0.0244

GLY 1507 CYS 1508 0.0106

CYS 1508 THR 1509 0.0268

THR 1509 ARG 1510 0.0335

ARG 1510 ALA 1511 0.0037

ALA 1511 VAL 1512 0.0329

VAL 1512 LEU 1513 0.0170

LEU 1513 ASP 1514 0.0342

ASP 1514 ALA 1515 0.0028

ALA 1515 LEU 1516 0.0333

LEU 1516 SER 1517 0.0184

SER 1517 ASN 1518 0.0304

ASN 1518 GLN 1519 0.0144

GLN 1519 GLY 1520 0.0198

GLY 1520 ILE 1521 0.0262

ILE 1521 ALA 1522 0.0310

ALA 1522 ARG 1523 0.0027

ARG 1523 CYS 1524 0.0339

CYS 1524 ALA 1525 0.0305

ALA 1525 GLN 1526 0.0256

GLN 1526 TYR 1527 0.0338

TYR 1527 ASP 1528 0.0314

ASP 1528 PHE 1529 0.0275

PHE 1529 THR 1530 0.0342

THR 1530 ASP 1531 0.0316

ASP 1531 VAL 1532 0.0332

VAL 1532 SER 1533 0.0105

SER 1533 SER 1534 0.0233

SER 1534 GLY 1535 0.0295

GLY 1535 PHE 1536 0.0272

PHE 1536 PHE 1537 0.0356

PHE 1537 GLU 1538 0.0082

GLU 1538 ALA 1539 0.0325

ALA 1539 ALA 1540 0.0095

ALA 1540 GLN 1541 0.0288

GLN 1541 GLN 1542 0.0253

GLN 1542 LYS 1543 0.0125

LYS 1543 PHE 1544 0.0249

PHE 1544 ALA 1545 0.0191

ALA 1545 ALA 1546 0.0242

ALA 1546 PHE 1547 0.0212

PHE 1547 ASP 1548 0.0209

ASP 1548 ASP 1549 0.0370

ASP 1549 VAL 1550 0.0107

VAL 1550 ILE 1551 0.0326

ILE 1551 ARG 1552 0.0337

ARG 1552 PHE 1553 0.0309

PHE 1553 GLN 1554 0.0351

GLN 1554 LYS 1555 0.0359

LYS 1555 LEU 1556 0.0057

LEU 1556 ASP 1557 0.0333

ASP 1557 ILE 1558 0.0002

ILE 1558 GLU 1559 0.0356

GLU 1559 LYS 1560 0.0296

LYS 1560 ASP 1561 0.0307

ASP 1561 ILE 1562 0.0360

ILE 1562 GLU 1563 0.0350

GLU 1563 MET 1564 0.0155

MET 1564 GLN 1565 0.0327

GLN 1565 GLY 1566 0.0362

GLY 1566 PHE 1567 0.0118

PHE 1567 GLU 1568 0.0178

GLU 1568 CYS 1569 0.0062

CYS 1569 GLY 1570 0.0168

GLY 1570 SER 1571 0.0216

SER 1571 TYR 1572 0.0360

TYR 1572 ASP 1573 0.0202

ASP 1573 LEU 1574 0.0338

LEU 1574 VAL 1575 0.0309

VAL 1575 ILE 1576 0.0320

ILE 1576 ALA 1577 0.0350

ALA 1577 SER 1578 0.0338

SER 1578 GLN 1579 0.0356

GLN 1579 VAL 1580 0.0325

VAL 1580 LEU 1581 0.0130

LEU 1581 HIS 1582 0.0356

HIS 1582 ALA 1583 0.0080

ALA 1583 THR 1584 0.0320

THR 1584 GLY 1585 0.0338

GLY 1585 LYS 1586 0.0068

LYS 1586 MET 1587 0.0281

MET 1587 GLU 1588 0.0221

GLU 1588 HIS 1589 0.0143

HIS 1589 THR 1590 0.0272

THR 1590 MET 1591 0.0137

MET 1591 ALA 1592 0.0351

ALA 1592 ASN 1593 0.0052

ASN 1593 VAL 1594 0.0355

VAL 1594 ARG 1595 0.0120

ARG 1595 LYS 1596 0.0262

LYS 1596 LEU 1597 0.0280

LEU 1597 LEU 1598 0.0143

LEU 1598 LYS 1599 0.0271

LYS 1599 PRO 1600 0.0007

PRO 1600 GLY 1601 0.0335

GLY 1601 GLY 1602 0.0054

GLY 1602 LYS 1603 0.0357

LYS 1603 LEU 1604 0.0301

LEU 1604 LEU 1605 0.0324

LEU 1605 LEU 1606 0.0352

LEU 1606 VAL 1607 0.0310

VAL 1607 GLU 1608 0.0359

GLU 1608 THR 1609 0.0360

THR 1609 THR 1610 0.0018

THR 1610 ARG 1611 0.0359

ARG 1611 ASP 1612 0.0113

ASP 1612 GLU 1613 0.0465

GLU 1613 MET 1614 0.0252

MET 1614 ASP 1615 0.0119

ASP 1615 LEU 1616 0.0373

LEU 1616 GLN 1617 0.0363

GLN 1617 LEU 1618 0.0182

LEU 1618 VAL 1619 0.0206

VAL 1619 PHE 1620 0.0360

PHE 1620 GLY 1621 0.0334

GLY 1621 LEU 1622 0.0033

LEU 1622 LEU 1623 0.0367

LEU 1623 PRO 1624 0.0353

PRO 1624 GLY 1625 0.0295

GLY 1625 TRP 1626 0.0197

TRP 1626 TRP 1627 0.0336

TRP 1627 LEU 1628 0.0373

LEU 1628 SER 1629 -0.0029

SER 1629 SER 1630 0.0320

SER 1630 GLU 1631 0.0055

GLU 1631 GLU 1632 0.0300

GLU 1632 GLU 1633 0.0337

GLU 1633 ARG 1634 0.0053

ARG 1634 GLN 1635 0.0279

GLN 1635 MET 1636 0.0376

MET 1636 SER 1637 0.0372

SER 1637 PRO 1638 0.0340

PRO 1638 SER 1639 0.0194

SER 1639 LEU 1640 0.0057

LEU 1640 SER 1641 0.0139

SER 1641 THR 1642 0.0316

THR 1642 ASN 1643 0.0149

ASN 1643 SER 1644 0.0232

SER 1644 TRP 1645 0.0331

TRP 1645 GLU 1646 0.0070

GLU 1646 LYS 1647 0.0346

LYS 1647 VAL 1648 0.0065

VAL 1648 LEU 1649 0.0353

LEU 1649 LYS 1650 0.0074

LYS 1650 LYS 1651 0.0313

LYS 1651 THR 1652 0.0118

THR 1652 GLY 1653 0.0294

GLY 1653 PHE 1654 0.0351

PHE 1654 ASP 1655 0.0074

ASP 1655 GLY 1656 0.0344

GLY 1656 LEU 1657 0.0318

LEU 1657 ASP 1658 0.0341

ASP 1658 ILE 1659 0.0294

ILE 1659 GLU 1660 0.0324

GLU 1660 LEU 1661 0.0309

LEU 1661 ARG 1662 0.0334

ARG 1662 ASP 1663 0.0124

ASP 1663 CYS 1664 0.0230

CYS 1664 ASP 1665 0.0014

ASP 1665 SER 1666 0.0368

SER 1666 ASP 1667 0.0326

ASP 1667 GLU 1668 0.0220

GLU 1668 PHE 1669 0.0106

PHE 1669 TYR 1670 0.0368

TYR 1670 SER 1671 0.0218

SER 1671 PHE 1672 0.0359

PHE 1672 SER 1673 0.0210

SER 1673 VAL 1674 0.0353

VAL 1674 MET 1675 0.0249

MET 1675 MET 1676 0.0350

MET 1676 ALA 1677 0.0567

ALA 1677 THR 1678 0.0268

THR 1678 ALA 1679 0.0275

ALA 1679 SER 1680 0.0055

SER 1680 SER 1681 0.0272

SER 1681 THR 1682 0.0149

THR 1682 ILE 1683 0.0186

ILE 1683 ALA 1684 0.0275

ALA 1684 SER 1685 0.0011

SER 1685 SER 1686 0.0286

SER 1686 SER 1687 0.0084

SER 1687 MET 1688 0.0284

MET 1688 ALA 1689 0.0107

ALA 1689 PHE 1690 0.0286

PHE 1690 ALA 1691 0.0231

ALA 1691 ILE 1692 0.0280

ILE 1692 VAL 1693 0.0214

VAL 1693 TYR 1694 0.0229

TYR 1694 GLY 1695 0.0259

GLY 1695 GLU 1696 0.0111

GLU 1696 VAL 1697 0.0241

VAL 1697 PRO 1698 0.0233

PRO 1698 LEU 1699 0.0213

LEU 1699 PRO 1700 0.0177

PRO 1700 ASP 1701 0.0203

ASP 1701 GLN 1702 0.0234

GLN 1702 PHE 1703 0.0026

PHE 1703 LEU 1704 0.0256

LEU 1704 ASP 1705 0.0221

ASP 1705 ASP 1706 0.0129

ASP 1706 MET 1707 0.0144

MET 1707 LYS 1708 0.0216

LYS 1708 THR 1709 0.0300

THR 1709 ALA 1710 0.0025

ALA 1710 ILE 1711 0.0242

ILE 1711 SER 1712 0.0185

SER 1712 SER 1713 0.0221

SER 1713 SER 1714 0.0050

SER 1714 ALA 1715 0.0250

ALA 1715 VAL 1716 0.0206

VAL 1716 SER 1717 0.0157

SER 1717 ASP 1718 0.0145

ASP 1718 PRO 1719 0.0243

PRO 1719 VAL 1720 0.0185

VAL 1720 VAL 1721 0.0248

VAL 1721 GLY 1722 0.0258

GLY 1722 HIS 1723 0.0262

HIS 1723 LEU 1724 0.0085

LEU 1724 ASP 1725 0.0235

ASP 1725 SER 1726 0.0191

SER 1726 ILE 1727 0.0160

ILE 1727 ASP 1728 0.0209

ASP 1728 ALA 1729 0.0036

ALA 1729 THR 1730 0.0233

THR 1730 GLY 1731 0.0178

GLY 1731 LYS 1732 0.0240

LYS 1732 PHE 1733 0.0169

PHE 1733 CYS 1734 0.0215

CYS 1734 ILE 1735 0.0253

ILE 1735 PHE 1736 0.0244

PHE 1736 ILE 1737 0.0225

ILE 1737 GLU 1738 0.0256

GLU 1738 ASP 1739 0.0172

ASP 1739 PRO 1740 0.0160

PRO 1740 GLU 1741 0.0065

GLU 1741 THR 1742 0.0234

THR 1742 ASP 1743 0.0040

ASP 1743 ILE 1744 0.0229

ILE 1744 LEU 1745 0.0036

LEU 1745 SER 1746 0.0238

SER 1746 SER 1747 0.0123

SER 1747 PRO 1748 0.0213

PRO 1748 ASP 1749 0.0099

ASP 1749 GLU 1750 0.0238

GLU 1750 LYS 1751 0.0168

LYS 1751 SER 1752 0.0193

SER 1752 TYR 1753 0.0046

TYR 1753 ALA 1754 0.0224

ALA 1754 SER 1755 0.0208

SER 1755 ILE 1756 0.0062

ILE 1756 GLN 1757 0.0198

GLN 1757 LYS 1758 0.0163

LYS 1758 LEU 1759 0.0243

LEU 1759 VAL 1760 0.0002

VAL 1760 THR 1761 0.0246

THR 1761 ARG 1762 0.0148

ARG 1762 CYS 1763 0.0239

CYS 1763 LYS 1764 0.0150

LYS 1764 GLY 1765 0.0220

GLY 1765 LEU 1766 0.0225

LEU 1766 ILE 1767 0.0246

ILE 1767 TRP 1768 0.0234

TRP 1768 VAL 1769 0.0227

VAL 1769 SER 1770 0.0241

SER 1770 ARG 1771 0.0246

ARG 1771 GLY 1772 0.0128

GLY 1772 GLY 1773 0.0242

GLY 1773 ALA 1774 0.0069

ALA 1774 MET 1775 0.0164

MET 1775 HIS 1776 0.0212

HIS 1776 GLY 1777 0.0180

GLY 1777 THR 1778 0.0091

THR 1778 ARG 1779 0.0167

ARG 1779 PRO 1780 0.0142

PRO 1780 ASN 1781 0.0128

ASN 1781 SER 1782 0.0228

SER 1782 SER 1783 0.0022

SER 1783 LEU 1784 0.0217

LEU 1784 LYS 1785 0.0215

LYS 1785 THR 1786 0.0054

THR 1786 GLY 1787 0.0177

GLY 1787 LEU 1788 0.0148

LEU 1788 LEU 1789 0.0271

LEU 1789 ARG 1790 0.0004

ARG 1790 THR 1791 0.0238

THR 1791 LEU 1792 0.0136

LEU 1792 ARG 1793 0.0146

ARG 1793 LEU 1794 0.0141

LEU 1794 GLU 1795 0.0124

GLU 1795 TYR 1796 0.0205

TYR 1796 THR 1797 0.0114

THR 1797 GLU 1798 0.0159

GLU 1798 LYS 1799 0.0120

LYS 1799 ARG 1800 0.0240

ARG 1800 PHE 1801 0.0229

PHE 1801 ILE 1802 0.0241

ILE 1802 SER 1803 0.0232

SER 1803 LEU 1804 0.0204

LEU 1804 ASP 1805 0.0306

ASP 1805 LEU 1806 0.0168

LEU 1806 ASP 1807 0.0260

ASP 1807 SER 1808 0.0215

SER 1808 ALA 1809 0.0259

ALA 1809 ARG 1810 0.0170

ARG 1810 PRO 1811 0.0015

PRO 1811 GLN 1812 0.0252

GLN 1812 TRP 1813 0.0210

TRP 1813 ASN 1814 0.0238

ASN 1814 HIS 1815 0.0246

HIS 1815 ASP 1816 0.0019

ASP 1816 SER 1817 0.0259

SER 1817 ILE 1818 0.0223

ILE 1818 THR 1819 0.0134

THR 1819 THR 1820 0.0126

THR 1820 ILE 1821 0.0228

ILE 1821 ASN 1822 0.0282

ASN 1822 GLU 1823 0.0044

GLU 1823 VAL 1824 0.0241

VAL 1824 LEU 1825 0.0197

LEU 1825 CYS 1826 0.0256

CYS 1826 GLY 1827 0.0035

GLY 1827 ALA 1828 0.0277

ALA 1828 LEU 1829 0.0248

LEU 1829 ALA 1830 0.0187

ALA 1830 GLN 1831 0.0076

GLN 1831 ASN 1832 0.0261

ASN 1832 ALA 1833 0.0160

ALA 1833 ASP 1834 0.0067

ASP 1834 SER 1835 0.0283

SER 1835 SER 1836 0.0211

SER 1836 ILE 1837 0.0146

ILE 1837 LYS 1838 0.0013

LYS 1838 ASP 1839 0.0228

ASP 1839 SER 1840 0.0152

SER 1840 GLU 1841 0.0265

GLU 1841 PHE 1842 0.0227

PHE 1842 ALA 1843 0.0245

ALA 1843 GLU 1844 0.0195

GLU 1844 GLN 1845 0.0253

GLN 1845 ASP 1846 0.0230

ASP 1846 GLY 1847 0.0243

GLY 1847 GLN 1848 0.0053

GLN 1848 LEU 1849 0.0249

LEU 1849 PHE 1850 0.0097

PHE 1850 VAL 1851 0.0181

VAL 1851 PRO 1852 0.0175

PRO 1852 ARG 1853 -0.0061

ARG 1853 ILE 1854 0.0173

ILE 1854 SER 1855 0.0057

SER 1855 CYS 1856 0.0129

CYS 1856 ASP 1857 0.0194

ASP 1857 ILE 1858 0.0022

ILE 1858 ALA 1859 0.0197

ALA 1859 ARG 1860 0.0162

ARG 1860 ASN 1861 0.0105

ASN 1861 GLU 1862 0.0104

GLU 1862 ASP 1863 0.0149

ASP 1863 LEU 1864 0.0202

LEU 1864 SER 1865 0.0015

SER 1865 SER 1866 0.0188

SER 1866 ASP 1867 0.0199

ASP 1867 SER 1868 0.0074

SER 1868 ASN 1869 0.0036

ASN 1869 SER 1870 0.0008

SER 1870 PRO 1871 0.0022

PRO 1871 ALA 1872 0.0000

ALA 1872 GLN 1873 0.0016

GLN 1873 MET 1874 0.0006

MET 1874 GLU 1875 0.0007

GLU 1875 PRO 1876 0.0004

PRO 1876 PHE 1877 0.0022

PHE 1877 HIS 1878 0.0003

HIS 1878 GLN 1879 0.0022

GLN 1879 PRO 1880 0.0013

PRO 1880 GLY 1881 0.0019

GLY 1881 LYS 1882 0.0004

LYS 1882 LEU 1883 0.0020

LEU 1883 LEU 1884 0.0012

LEU 1884 GLN 1885 0.0131

GLN 1885 MET 1886 0.0026

MET 1886 GLY 1887 0.0001

GLY 1887 ILE 1888 0.0018

ILE 1888 LYS 1889 0.0006

LYS 1889 THR 1890 0.0019

THR 1890 PRO 1891 0.0022

PRO 1891 GLY 1892 0.0026

GLY 1892 LEU 1893 0.0024

LEU 1893 ILE 1894 -0.0002

ILE 1894 ASP 1895 0.0026

ASP 1895 THR 1896 0.0021

THR 1896 LEU 1897 0.0009

LEU 1897 GLN 1898 0.0024

GLN 1898 PHE 1899 0.0021

PHE 1899 SER 1900 0.0020

SER 1900 LYS 1901 0.0035

LYS 1901 THR 1902 0.0019

THR 1902 ASP 1903 0.0016

ASP 1903 ALA 1904 0.0003

ALA 1904 THR 1905 0.0017

THR 1905 ASP 1906 0.0003

ASP 1906 ASN 1907 0.0018

ASN 1907 LEU 1908 0.0015

LEU 1908 PRO 1909 0.0019

PRO 1909 ASN 1910 0.0009

ASN 1910 ASP 1911 0.0017

ASP 1911 TYR 1912 0.0017

TYR 1912 ILE 1913 0.0013

ILE 1913 GLU 1914 0.0017

GLU 1914 ILE 1915 0.0018

ILE 1915 GLU 1916 0.0020

GLU 1916 PRO 1917 0.0083

PRO 1917 LYS 1918 0.0010

LYS 1918 ALA 1919 0.0014

ALA 1919 PHE 1920 0.0006

PHE 1920 GLY 1921 0.0015

GLY 1921 LEU 1922 0.0004

LEU 1922 ASN 1923 0.0014

ASN 1923 PHE 1924 0.0009

PHE 1924 ARG 1925 0.0013

ARG 1925 ASP 1926 0.0017

ASP 1926 VAL 1927 0.0014

VAL 1927 MET 1928 0.0011

MET 1928 VAL 1929 0.0017

VAL 1929 ALA 1930 0.0018

ALA 1930 MET 1931 0.0011

MET 1931 GLY 1932 0.0013

GLY 1932 GLN 1933 -0.0125

GLN 1933 LEU 1934 0.0015

LEU 1934 GLU 1935 0.0007

GLU 1935 GLU 1936 0.0007

GLU 1936 SER 1937 0.0015

SER 1937 ILE 1938 0.0001

ILE 1938 MET 1939 0.0004

MET 1939 GLY 1940 0.0002

GLY 1940 PHE 1941 0.0013

PHE 1941 GLU 1942 -0.0001

GLU 1942 CYS 1943 0.0009

CYS 1943 ALA 1944 0.0001

ALA 1944 GLY 1945 0.0014

GLY 1945 VAL 1946 0.0012

VAL 1946 VAL 1947 0.0013

VAL 1947 ARG 1948 0.0012

ARG 1948 ARG 1949 0.0087

ARG 1949 VAL 1950 0.0016

VAL 1950 GLY 1951 0.0013

GLY 1951 PRO 1952 0.0014

PRO 1952 SER 1953 0.0016

SER 1953 SER 1954 0.0016

SER 1954 ALA 1955 0.0001

ALA 1955 GLY 1956 0.0017

GLY 1956 HIS 1957 0.0017

HIS 1957 ASN 1958 0.0008

ASN 1958 ILE 1959 0.0014

ILE 1959 LYS 1960 0.0013

LYS 1960 VAL 1961 0.0017

VAL 1961 GLY 1962 0.0014

GLY 1962 ASP 1963 0.0020

ASP 1963 ARG 1964 0.0015

ARG 1964 VAL 1965 -0.0008

VAL 1965 CYS 1966 0.0007

CYS 1966 ALA 1967 0.0005

ALA 1967 LEU 1968 0.0003

LEU 1968 LEU 1969 0.0009

LEU 1969 GLY 1970 0.0003

GLY 1970 GLY 1971 0.0016

GLY 1971 GLN 1972 0.0020

GLN 1972 TRP 1973 0.0014

TRP 1973 THR 1974 0.0016

THR 1974 ASN 1975 0.0008

ASN 1975 THR 1976 0.0018

THR 1976 VAL 1977 0.0017

VAL 1977 ARG 1978 0.0018

ARG 1978 VAL 1979 0.0019

VAL 1979 HIS 1980 0.0020

HIS 1980 TRP 1981 0.0040

TRP 1981 HIS 1982 0.0017

HIS 1982 SER 1983 0.0018

SER 1983 VAL 1984 0.0004

VAL 1984 ALA 1985 0.0002

ALA 1985 PRO 1986 0.0003

PRO 1986 ILE 1987 0.0015

ILE 1987 PRO 1988 0.0001

PRO 1988 GLN 1989 0.0013

GLN 1989 ALA 1990 0.0016

ALA 1990 MET 1991 -0.0000

MET 1991 ASP 1992 0.0013

ASP 1992 TRP 1993 0.0003

TRP 1993 GLU 1994 0.0014

GLU 1994 THR 1995 0.0016

THR 1995 ALA 1996 0.0016

ALA 1996 ALA 1997 0.0038

ALA 1997 SER 1998 0.0014

SER 1998 ILE 1999 0.0014

ILE 1999 PRO 2000 0.0008

PRO 2000 ILE 2001 0.0005

ILE 2001 VAL 2002 0.0013

VAL 2002 PHE 2003 0.0006

PHE 2003 VAL 2004 0.0009

VAL 2004 THR 2005 0.0004

THR 2005 ALA 2006 0.0007

ALA 2006 TYR 2007 0.0011

TYR 2007 ILE 2008 0.0005

ILE 2008 SER 2009 0.0011

SER 2009 LEU 2010 0.0005

LEU 2010 VAL 2011 0.0008

VAL 2011 LYS 2012 0.0006

LYS 2012 ILE 2013 -0.0146

ILE 2013 ALA 2014 0.0011

ALA 2014 ARG 2015 0.0002

ARG 2015 MET 2016 0.0009

MET 2016 GLN 2017 0.0005

GLN 2017 ALA 2018 0.0004

ALA 2018 GLY 2019 0.0008

GLY 2019 GLU 2020 0.0002

GLU 2020 THR 2021 0.0006

THR 2021 VAL 2022 0.0009

VAL 2022 LEU 2023 0.0005

LEU 2023 ILE 2024 0.0008

ILE 2024 HIS 2025 0.0005

HIS 2025 ALA 2026 0.0010

ALA 2026 ALA 2027 0.0002

ALA 2027 SER 2028 0.0009

SER 2028 GLY 2029 0.0083

GLY 2029 GLY 2030 0.0007

GLY 2030 VAL 2031 0.0012

VAL 2031 GLY 2032 0.0012

GLY 2032 GLN 2033 -0.0001

GLN 2033 ALA 2034 0.0012

ALA 2034 ALA 2035 0.0011

ALA 2035 ILE 2036 0.0008

ILE 2036 ILE 2037 0.0005

ILE 2037 LEU 2038 0.0012

LEU 2038 ALA 2039 0.0011

ALA 2039 LYS 2040 0.0001

LYS 2040 HIS 2041 0.0009

HIS 2041 VAL 2042 0.0008

VAL 2042 GLY 2043 0.0009

GLY 2043 ALA 2044 0.0002

ALA 2044 GLU 2045 -0.0062

GLU 2045 ILE 2046 0.0007

ILE 2046 PHE 2047 0.0004

PHE 2047 ALA 2048 0.0009

ALA 2048 THR 2049 0.0004

THR 2049 VAL 2050 0.0011

VAL 2050 GLY 2051 0.0006

GLY 2051 THR 2052 0.0011

THR 2052 ASP 2053 0.0003

ASP 2053 GLU 2054 0.0007

GLU 2054 LYS 2055 0.0012

LYS 2055 ARG 2056 0.0011

ARG 2056 ASP 2057 0.0004

ASP 2057 LEU 2058 0.0010

LEU 2058 LEU 2059 0.0012

LEU 2059 ILE 2060 0.0010

ILE 2060 LYS 2061 -0.0019

LYS 2061 GLU 2062 0.0009

GLU 2062 TYR 2063 0.0009

TYR 2063 LYS 2064 0.0007

LYS 2064 ILE 2065 0.0003

ILE 2065 PRO 2066 0.0009

PRO 2066 ASP 2067 0.0005

ASP 2067 ASP 2068 0.0009

ASP 2068 HIS 2069 0.0009

HIS 2069 ILE 2070 0.0007

ILE 2070 PHE 2071 0.0001

PHE 2071 SER 2072 0.0005

SER 2072 SER 2073 0.0009

SER 2073 ARG 2074 0.0004

ARG 2074 ASN 2075 0.0010

ASN 2075 ALA 2076 0.0009

ALA 2076 LEU 2077 0.0055

LEU 2077 PHE 2078 0.0000

PHE 2078 ALA 2079 0.0004

ALA 2079 LYS 2080 0.0006

LYS 2080 SER 2081 0.0000

SER 2081 ILE 2082 0.0006

ILE 2082 ARG 2083 0.0006

ARG 2083 GLN 2084 0.0008

GLN 2084 ARG 2085 0.0003

ARG 2085 THR 2086 0.0007

THR 2086 ASN 2087 0.0004

ASN 2087 GLY 2088 0.0003

GLY 2088 LYS 2089 0.0004

LYS 2089 GLY 2090 0.0004

GLY 2090 VAL 2091 0.0004

VAL 2091 ASP 2092 0.0003

ASP 2092 VAL 2093 0.0022

VAL 2093 VAL 2094 0.0002

VAL 2094 LEU 2095 0.0006

LEU 2095 ASN 2096 0.0000

ASN 2096 CYS 2097 0.0006

CYS 2097 LEU 2098 0.0002

LEU 2098 ALA 2099 0.0001

ALA 2099 GLY 2100 0.0004

GLY 2100 GLY 2101 0.0006

GLY 2101 LEU 2102 0.0002

LEU 2102 LEU 2103 0.0007

LEU 2103 GLN 2104 0.0007

GLN 2104 GLU 2105 0.0006

GLU 2105 SER 2106 0.0002

SER 2106 PHE 2107 0.0007

PHE 2107 ASP 2108 0.0005

ASP 2108 CYS 2109 -0.0032

CYS 2109 LEU 2110 0.0005

LEU 2110 ALA 2111 0.0007

ALA 2111 ASP 2112 0.0006

ASP 2112 PHE 2113 0.0005

PHE 2113 GLY 2114 0.0008

GLY 2114 ARG 2115 0.0005

ARG 2115 PHE 2116 0.0002

PHE 2116 ILE 2117 0.0006

ILE 2117 GLU 2118 0.0004

GLU 2118 ILE 2119 0.0005

ILE 2119 GLY 2120 0.0003

GLY 2120 LYS 2121 0.0004

LYS 2121 ARG 2122 0.0000

ARG 2122 ASP 2123 0.0005

ASP 2123 ILE 2124 0.0004

ILE 2124 GLU 2125 0.0039

GLU 2125 LEU 2126 0.0001

LEU 2126 ASN 2127 0.0005

ASN 2127 HIS 2128 0.0004

HIS 2128 CYS 2129 0.0007

CYS 2129 LEU 2130 0.0002

LEU 2130 ASN 2131 0.0006

ASN 2131 MET 2132 0.0005

MET 2132 GLY 2133 0.0006

GLY 2133 MET 2134 0.0002

MET 2134 PHE 2135 0.0003

PHE 2135 ALA 2136 0.0005

ALA 2136 ARG 2137 0.0002

ARG 2137 SER 2138 0.0004

SER 2138 ALA 2139 0.0004

ALA 2139 THR 2140 0.0006

THR 2140 PHE 2141 0.0105

PHE 2141 THR 2142 0.0012

THR 2142 ALA 2143 0.0012

ALA 2143 VAL 2144 0.0008

VAL 2144 ASP 2145 0.0010

ASP 2145 LEU 2146 0.0007

LEU 2146 ILE 2147 0.0004

ILE 2147 ALA 2148 0.0010

ALA 2148 ILE 2149 0.0002

ILE 2149 GLY 2150 0.0011

GLY 2150 ARG 2151 0.0004

ARG 2151 ASP 2152 0.0010

ASP 2152 ARG 2153 0.0002

ARG 2153 SER 2154 0.0008

SER 2154 TYR 2155 0.0006

TYR 2155 MET 2156 0.0011

MET 2156 PHE 2157 -0.0115

PHE 2157 ALA 2158 0.0009

ALA 2158 GLU 2159 0.0014

GLU 2159 ALA 2160 0.0017

ALA 2160 LEU 2161 0.0013

LEU 2161 PRO 2162 0.0003

PRO 2162 LYS 2163 0.0015

LYS 2163 ILE 2164 0.0014

ILE 2164 MET 2165 0.0010

MET 2165 THR 2166 0.0007

THR 2166 LEU 2167 0.0015

LEU 2167 LEU 2168 0.0014

LEU 2168 GLN 2169 0.0005

GLN 2169 GLU 2170 0.0011

GLU 2170 LYS 2171 0.0013

LYS 2171 ALA 2172 0.0013

ALA 2172 ILE 2173 -0.0008

ILE 2173 ARG 2174 0.0016

ARG 2174 PRO 2175 0.0009

PRO 2175 VAL 2176 0.0007

VAL 2176 THR 2177 0.0017

THR 2177 PRO 2178 0.0016

PRO 2178 ILE 2179 0.0015

ILE 2179 SER 2180 0.0011

SER 2180 ILE 2181 0.0016

ILE 2181 TYR 2182 0.0007

TYR 2182 LYS 2183 0.0016

LYS 2183 ILE 2184 0.0007

ILE 2184 GLY 2185 0.0015

GLY 2185 ASP 2186 0.0015

ASP 2186 ILE 2187 0.0012

ILE 2187 GLU 2188 0.0004

GLU 2188 THR 2189 0.0128

THR 2189 ALA 2190 0.0012

ALA 2190 PHE 2191 0.0004

PHE 2191 ARG 2192 0.0015

ARG 2192 LEU 2193 0.0007

LEU 2193 MET 2194 0.0015

MET 2194 GLN 2195 0.0003

GLN 2195 ALA 2196 0.0015

ALA 2196 GLY 2197 0.0011

GLY 2197 LYS 2198 0.0006

LYS 2198 HIS 2199 0.0010

HIS 2199 MET 2200 0.0006

MET 2200 GLY 2201 0.0013

GLY 2201 LYS 2202 0.0015

LYS 2202 ILE 2203 0.0015

ILE 2203 VAL 2204 0.0012

VAL 2204 ILE 2205 -0.0007

ILE 2205 THR 2206 0.0012

THR 2206 ALA 2207 0.0033

ALA 2207 PRO 2208 0.0015

PRO 2208 GLU 2209 0.0031

GLU 2209 ASP 2210 0.0026

ASP 2210 ALA 2211 0.0009

ALA 2211 MET 2212 0.0009

MET 2212 VAL 2213 0.0012

VAL 2213 PRO 2214 0.0003

PRO 2214 VAL 2215 0.0031

VAL 2215 ILE 2216 0.0012

ILE 2216 THR 2217 0.0031

THR 2217 ARG 2218 0.0021

ARG 2218 PRO 2219 0.0031

PRO 2219 PRO 2220 0.0027

PRO 2220 LYS 2221 0.0696

LYS 2221 LEU 2222 0.0036

LEU 2222 GLN 2223 0.0148

GLN 2223 LEU 2224 0.0047

LEU 2224 ARG 2225 0.0133

ARG 2225 PRO 2226 0.0146

PRO 2226 ASP 2227 0.0050

ASP 2227 ALA 2228 0.0092

ALA 2228 SER 2229 0.0125

SER 2229 TYR 2230 0.0149

TYR 2230 LEU 2231 0.0073

LEU 2231 ILE 2232 0.0141

ILE 2232 VAL 2233 0.0068

VAL 2233 GLY 2234 0.0132

GLY 2234 GLY 2235 0.0061

GLY 2235 LEU 2236 0.0148

LEU 2236 GLY 2237 -0.0020

GLY 2237 GLY 2238 0.0029

GLY 2238 ILE 2239 0.0140

ILE 2239 GLY 2240 0.0113

GLY 2240 ARG 2241 0.0061

ARG 2241 SER 2242 0.0084

SER 2242 LEU 2243 0.0104

LEU 2243 CYS 2244 0.0140

CYS 2244 LYS 2245 0.0002

LYS 2245 ASN 2246 0.0141

ASN 2246 PHE 2247 0.0085

PHE 2247 VAL 2248 0.0113

VAL 2248 GLU 2249 0.0028

GLU 2249 ASN 2250 0.0122

ASN 2250 GLY 2251 0.0129

GLY 2251 ALA 2252 0.0031

ALA 2252 ARG 2253 0.0238

ARG 2253 SER 2254 0.0015

SER 2254 LEU 2255 0.0136

LEU 2255 VAL 2256 0.0022

VAL 2256 LEU 2257 0.0154

LEU 2257 LEU 2258 0.0028

LEU 2258 SER 2259 0.0149

SER 2259 ARG 2260 0.0061

ARG 2260 ASN 2261 0.0114

ASN 2261 ALA 2262 0.0111

ALA 2262 ASN 2263 0.0155

ASN 2263 VAL 2264 0.0073

VAL 2264 SER 2265 0.0096

SER 2265 GLN 2266 0.0114

GLN 2266 GLN 2267 0.0137

GLN 2267 SER 2268 0.0151

SER 2268 GLY 2269 0.0302

GLY 2269 GLU 2270 0.0020

GLU 2270 PHE 2271 0.0148

PHE 2271 LEU 2272 0.0109

LEU 2272 ASP 2273 0.0074

ASP 2273 GLU 2274 0.0098

GLU 2274 LEU 2275 0.0103

LEU 2275 ARG 2276 0.0156

ARG 2276 SER 2277 0.0003

SER 2277 THR 2278 0.0158

THR 2278 GLY 2279 0.0106

GLY 2279 CYS 2280 0.0062

CYS 2280 ILE 2281 0.0030

ILE 2281 VAL 2282 0.0134

VAL 2282 GLY 2283 0.0007

GLY 2283 VAL 2284 0.0145

VAL 2284 VAL 2285 -0.0103

VAL 2285 ASP 2286 0.0101

ASP 2286 CYS 2287 0.0123

CYS 2287 ASP 2288 0.0135

ASP 2288 ILE 2289 0.0163

ILE 2289 SER 2290 0.0077

SER 2290 SER 2291 0.0105

SER 2291 LYS 2292 0.0154

LYS 2292 THR 2293 0.0152

THR 2293 GLN 2294 0.0039

GLN 2294 VAL 2295 0.0124

VAL 2295 GLU 2296 0.0119

GLU 2296 ALA 2297 0.0164

ALA 2297 THR 2298 0.0008

THR 2298 MET 2299 0.0162

MET 2299 LEU 2300 0.0129

LEU 2300 ARG 2301 -0.0047

ARG 2301 LEU 2302 0.0049

LEU 2302 LYS 2303 0.0149

LYS 2303 LYS 2304 0.0157

LYS 2304 ASP 2305 0.0067

ASP 2305 MET 2306 0.0088

MET 2306 LEU 2307 0.0128

LEU 2307 PRO 2308 0.0123

PRO 2308 ILE 2309 0.0157

ILE 2309 ARG 2310 0.0112

ARG 2310 GLY 2311 0.0152

GLY 2311 ILE 2312 0.0136

ILE 2312 VAL 2313 0.0137

VAL 2313 HIS 2314 0.0084

HIS 2314 ALA 2315 0.0124

ALA 2315 GLY 2316 0.0056

GLY 2316 MET 2317 0.0732

MET 2317 VAL 2318 0.0174

VAL 2318 LEU 2319 0.0212

LEU 2319 GLN 2320 0.0120

GLN 2320 ASP 2321 0.0194

ASP 2321 SER 2322 0.0133

SER 2322 VAL 2323 0.0215

VAL 2323 PHE 2324 0.0099

PHE 2324 GLU 2325 0.0141

GLU 2325 ARG 2326 0.0219

ARG 2326 MET 2327 0.0218

MET 2327 SER 2328 0.0087

SER 2328 LEU 2329 0.0177

LEU 2329 ASP 2330 0.0192

ASP 2330 ASP 2331 0.0030

ASP 2331 TYR 2332 0.0218

TYR 2332 ASN 2333 0.0330

ASN 2333 THR 2334 0.0107

THR 2334 ALA 2335 0.0083

ALA 2335 ILE 2336 0.0174

ILE 2336 ARG 2337 0.0174

ARG 2337 PRO 2338 0.0051

PRO 2338 LYS 2339 0.0181

LYS 2339 VAL 2340 0.0044

VAL 2340 GLN 2341 0.0128

GLN 2341 GLY 2342 0.0083

GLY 2342 SER 2343 0.0154

SER 2343 TRP 2344 0.0050

TRP 2344 ASN 2345 0.0190

ASN 2345 LEU 2346 0.0033

LEU 2346 HIS 2347 0.0197

HIS 2347 SER 2348 0.0046

SER 2348 GLY 2349 -0.0019

GLY 2349 LEU 2350 0.0054

LEU 2350 SER 2351 0.0138

SER 2351 ASP 2352 0.0167

ASP 2352 CYS 2353 0.0009

CYS 2353 ASP 2354 0.0090

ASP 2354 LEU 2355 0.0118

LEU 2355 ASP 2356 0.0020

ASP 2356 PHE 2357 0.0169

PHE 2357 PHE 2358 0.0096

PHE 2358 ILE 2359 0.0142

ILE 2359 MET 2360 0.0131

MET 2360 LEU 2361 0.0125

LEU 2361 SER 2362 0.0129

SER 2362 SER 2363 0.0152

SER 2363 LEU 2364 0.0143

LEU 2364 ALA 2365 0.0089

ALA 2365 GLY 2366 0.0123

GLY 2366 VAL 2367 0.0150

VAL 2367 SER 2368 0.0191

SER 2368 GLY 2369 0.0082

GLY 2369 SER 2370 0.0216

SER 2370 ALA 2371 0.0176

ALA 2371 SER 2372 0.0135

SER 2372 GLN 2373 0.0223

GLN 2373 ALA 2374 0.0101

ALA 2374 ASN 2375 0.0195

ASN 2375 TYR 2376 0.0051

TYR 2376 THR 2377 0.0207

THR 2377 ALA 2378 0.0052

ALA 2378 GLY 2379 0.0213

GLY 2379 GLY 2380 0.0042

GLY 2380 ALA 2381 0.0120

ALA 2381 TYR 2382 0.0113

TYR 2382 GLN 2383 0.0093

GLN 2383 ASP 2384 0.0151

ASP 2384 ALA 2385 0.0061

ALA 2385 LEU 2386 0.0187

LEU 2386 ALA 2387 0.0030

ALA 2387 LYS 2388 0.0185

LYS 2388 TYR 2389 0.0036

TYR 2389 ARG 2390 0.0165

ARG 2390 ARG 2391 0.0095

ARG 2391 ALA 2392 0.0104

ALA 2392 GLN 2393 0.0151

GLN 2393 GLY 2394 0.0053

GLY 2394 LEU 2395 0.0189

LEU 2395 SER 2396 0.0059

SER 2396 ALA 2397 0.0325

ALA 2397 VAL 2398 0.0097

VAL 2398 SER 2399 0.0183

SER 2399 ILE 2400 0.0054

ILE 2400 ASP 2401 0.0183

ASP 2401 LEU 2402 0.0108

LEU 2402 GLY 2403 0.0130

GLY 2403 MET 2404 0.0160

MET 2404 VAL 2405 0.0146

VAL 2405 GLN 2406 0.0076

GLN 2406 SER 2407 0.0172

SER 2407 VAL 2408 0.0046

VAL 2408 GLY 2409 0.0012

GLY 2409 TYR 2410 0.0140

TYR 2410 VAL 2411 0.0097

VAL 2411 ALA 2412 0.0087

ALA 2412 GLU 2413 0.0035

GLU 2413 THR 2414 0.0173

THR 2414 LYS 2415 0.0117

LYS 2415 GLY 2416 0.0192

GLY 2416 VAL 2417 0.0148

VAL 2417 ALA 2418 0.0067

ALA 2418 GLU 2419 0.0163

GLU 2419 ARG 2420 0.0046

ARG 2420 LEU 2421 0.0191

LEU 2421 VAL 2422 0.0024

VAL 2422 ARG 2423 0.0187

ARG 2423 MET 2424 0.0062

MET 2424 GLY 2425 0.0134

GLY 2425 TYR 2426 0.0191

TYR 2426 SER 2427 0.0072

SER 2427 PRO 2428 0.0185

PRO 2428 ILE 2429 0.0404

ILE 2429 SER 2430 0.0118

SER 2430 GLU 2431 0.0133

GLU 2431 MET 2432 0.0102

MET 2432 GLU 2433 0.0141

GLU 2433 VAL 2434 0.0020

VAL 2434 LEU 2435 0.0151

LEU 2435 LYS 2436 0.0125

LYS 2436 ILE 2437 0.0059

ILE 2437 VAL 2438 0.0100

VAL 2438 GLU 2439 0.0102

GLU 2439 HIS 2440 0.0157

HIS 2440 ALA 2441 0.0003

ALA 2441 ILE 2442 0.0158

ILE 2442 THR 2443 0.0077

THR 2443 ASN 2444 0.0154

ASN 2444 PRO 2445 -0.0155

PRO 2445 PRO 2446 0.0171

PRO 2446 PRO 2447 0.0173

PRO 2447 GLU 2448 0.0091

GLU 2448 ALA 2449 0.0066

ALA 2449 SER 2450 0.0173

SER 2450 SER 2451 0.0052

SER 2451 ALA 2452 0.0151

ALA 2452 GLN 2453 0.0178

GLN 2453 ILE 2454 0.0040

ILE 2454 ILE 2455 0.0182

ILE 2455 THR 2456 0.0099

THR 2456 GLY 2457 0.0162

GLY 2457 ILE 2458 0.0184

ILE 2458 SER 2459 0.0063

SER 2459 THR 2460 0.0144

THR 2460 LYS 2461 0.0007

LYS 2461 PRO 2462 0.0218

PRO 2462 GLY 2463 0.0196

GLY 2463 ARG 2464 0.0140

ARG 2464 HIS 2465 0.0106

HIS 2465 TRP 2466 0.0223

TRP 2466 THR 2467 0.0211

THR 2467 GLU 2468 0.0184

GLU 2468 SER 2469 0.0164

SER 2469 SER 2470 0.0046

SER 2470 TRP 2471 0.0218

TRP 2471 LEU 2472 0.0063

LEU 2472 GLN 2473 0.0195

GLN 2473 ASP 2474 0.0113

ASP 2474 ALA 2475 0.0222

ALA 2475 ARG 2476 0.0224

ARG 2476 PHE 2477 -0.0025

PHE 2477 ALA 2478 0.0242

ALA 2478 THR 2479 0.0178

THR 2479 LEU 2480 0.0217

LEU 2480 ARG 2481 0.0265

ARG 2481 GLU 2482 0.0189

GLU 2482 ARG 2483 0.0191

ARG 2483 ALA 2484 0.0263

ALA 2484 ARG 2485 0.0253

ARG 2485 ASP 2486 0.0176

ASP 2486 VAL 2487 0.0215

VAL 2487 LYS 2488 0.0269

LYS 2488 GLU 2489 0.0235

GLU 2489 LEU 2490 0.0179

LEU 2490 SER 2491 0.0225

SER 2491 ASN 2492 0.0258

ASN 2492 SER 2493 0.0440

SER 2493 GLN 2494 0.0127

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** sdgklnrdh ***

CA strain for 22101813491974862

--- normal mode 7 ---

Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *