Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *

CA strain for 22101813491974862

--- normal mode 26 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
ASN 989 LYS 990 0.0798

LYS 990 ALA 991 0.1043

ALA 991 HIS 992 0.0974

HIS 992 ARG 993 0.0412

ARG 993 GLN 994 0.1000

GLN 994 ARG 995 0.1039

ARG 995 VAL 996 0.0565

VAL 996 HIS 997 0.1038

HIS 997 PRO 998 0.1020

PRO 998 PRO 999 0.0712

PRO 999 HIS 1000 0.0981

HIS 1000 ASP 1001 0.1023

ASP 1001 LEU 1002 0.0663

LEU 1002 LEU 1003 0.0682

LEU 1003 GLY 1004 0.1039

GLY 1004 SER 1005 0.0915

SER 1005 LEU 1006 0.0539

LEU 1006 ILE 1007 0.0018

ILE 1007 VAL 1008 0.0588

VAL 1008 GLY 1009 0.0317

GLY 1009 ARG 1010 0.0600

ARG 1010 ASP 1011 0.0567

ASP 1011 LEU 1012 0.0010

LEU 1012 ARG 1013 0.0590

ARG 1013 GLU 1014 0.0520

GLU 1014 PRO 1015 0.0471

PRO 1015 THR 1016 0.0581

THR 1016 TRP 1017 0.0426

TRP 1017 ARG 1018 0.0522

ARG 1018 HIS 1019 0.0432

HIS 1019 PHE 1020 0.0577

PHE 1020 ILE 1021 0.0119

ILE 1021 ARG 1022 0.0237

ARG 1022 VAL 1023 0.0461

VAL 1023 GLN 1024 0.0188

GLN 1024 ASP 1025 0.0606

ASP 1025 ILE 1026 0.0566

ILE 1026 PRO 1027 0.0483

PRO 1027 TRP 1028 0.0568

TRP 1028 ILE 1029 0.0162

ILE 1029 ARG 1030 0.0513

ARG 1030 ASP 1031 0.0641

ASP 1031 HIS 1032 0.0004

HIS 1032 VAL 1033 0.0557

VAL 1033 VAL 1034 0.0118

VAL 1034 GLN 1035 0.0604

GLN 1035 SER 1036 0.0220

SER 1036 ALA 1037 -0.0418

ALA 1037 LEU 1038 0.0383

LEU 1038 VAL 1039 0.0433

VAL 1039 TYR 1040 0.0521

TYR 1040 PRO 1041 0.0528

PRO 1041 GLY 1042 0.0270

GLY 1042 ALA 1043 0.0262

ALA 1043 GLY 1044 0.0539

GLY 1044 PHE 1045 0.0100

PHE 1045 ILE 1046 0.0515

ILE 1046 CYS 1047 0.0139

CYS 1047 MET 1048 0.0414

MET 1048 ALA 1049 0.0370

ALA 1049 MET 1050 0.0209

MET 1050 GLU 1051 0.0438

GLU 1051 ALA 1052 0.0155

ALA 1052 MET 1053 0.0536

MET 1053 VAL 1054 0.0231

VAL 1054 GLN 1055 0.0549

GLN 1055 LEU 1056 0.0462

LEU 1056 HIS 1057 0.0285

HIS 1057 GLU 1058 0.0602

GLU 1058 LEU 1059 0.0202

LEU 1059 ARG 1060 0.0711

ARG 1060 ASP 1061 0.0165

ASP 1061 SER 1062 0.0490

SER 1062 GLN 1063 0.0535

GLN 1063 SER 1064 0.0415

SER 1064 ARG 1065 0.0698

ARG 1065 LYS 1066 0.0500

LYS 1066 VAL 1067 0.0527

VAL 1067 ALA 1068 0.0650

ALA 1068 GLY 1069 0.0593

GLY 1069 TYR 1070 0.0160

TYR 1070 ARG 1071 0.0212

ARG 1071 LEU 1072 0.0257

LEU 1072 ALA 1073 0.0174

ALA 1073 GLU 1074 0.0212

GLU 1074 VAL 1075 0.0377

VAL 1075 ASP 1076 0.0320

ASP 1076 ILE 1077 0.0423

ILE 1077 LEU 1078 0.0108

LEU 1078 ARG 1079 0.0434

ARG 1079 ALA 1080 0.0143

ALA 1080 MET 1081 0.0444

MET 1081 LEU 1082 0.0456

LEU 1082 ILE 1083 0.0252

ILE 1083 PRO 1084 0.0470

PRO 1084 ASP 1085 0.2258

ASP 1085 THR 1086 0.0461

THR 1086 SER 1087 0.0485

SER 1087 GLU 1088 0.0262

GLU 1088 GLY 1089 0.0511

GLY 1089 LEU 1090 0.0373

LEU 1090 GLU 1091 0.0489

GLU 1091 ALA 1092 0.0514

ALA 1092 HIS 1093 0.0511

HIS 1093 ILE 1094 0.0485

ILE 1094 SER 1095 0.0400

SER 1095 LEU 1096 0.0493

LEU 1096 ARG 1097 0.0293

ARG 1097 PRO 1098 0.0516

PRO 1098 CYS 1099 0.0478

CYS 1099 SER 1100 0.0253

SER 1100 THR 1101 0.0134

THR 1101 LYS 1102 0.0211

LYS 1102 LEU 1103 0.0137

LEU 1103 LEU 1104 0.0354

LEU 1104 LEU 1105 0.0041

LEU 1105 THR 1106 0.0304

THR 1106 ASN 1107 0.0238

ASN 1107 GLU 1108 0.0365

GLU 1108 TRP 1109 0.0370

TRP 1109 TYR 1110 0.0368

TYR 1110 ASP 1111 0.0324

ASP 1111 PHE 1112 0.0219

PHE 1112 CYS 1113 0.0357

CYS 1113 VAL 1114 0.0203

VAL 1114 SER 1115 0.0314

SER 1115 SER 1116 0.0343

SER 1116 VAL 1117 0.0171

VAL 1117 GLY 1118 0.0347

GLY 1118 ASP 1119 0.0315

ASP 1119 ASP 1120 0.0060

ASP 1120 ASP 1121 0.0352

ASP 1121 LYS 1122 0.0366

LYS 1122 PHE 1123 0.0211

PHE 1123 VAL 1124 0.0268

VAL 1124 ASP 1125 0.0298

ASP 1125 HIS 1126 0.0057

HIS 1126 CYS 1127 0.0324

CYS 1127 ARG 1128 0.0322

ARG 1128 GLY 1129 0.0304

GLY 1129 ARG 1130 0.0350

ARG 1130 ILE 1131 0.0166

ILE 1131 THR 1132 0.0327

THR 1132 ILE 1133 -0.0300

ILE 1133 GLU 1134 0.0512

GLU 1134 PHE 1135 0.0461

PHE 1135 ASP 1136 0.0283

ASP 1136 THR 1137 0.0501

THR 1137 SER 1138 0.0365

SER 1138 GLY 1139 0.0571

GLY 1139 SER 1140 0.0585

SER 1140 ALA 1141 0.0262

ALA 1141 ASP 1142 0.0601

ASP 1142 THR 1143 0.0284

THR 1143 PRO 1144 0.0294

PRO 1144 ARG 1145 0.0585

ARG 1145 THR 1146 0.0594

THR 1146 SER 1147 0.0136

SER 1147 LEU 1148 0.0610

LEU 1148 ARG 1149 -0.5975

ARG 1149 GLU 1150 0.0100

GLU 1150 ARG 1151 0.0553

ARG 1151 SER 1152 0.0291

SER 1152 ARG 1153 0.0369

ARG 1153 SER 1154 0.0602

SER 1154 THR 1155 0.0567

THR 1155 GLY 1156 0.0183

GLY 1156 LEU 1157 0.0049

LEU 1157 MET 1158 0.0361

MET 1158 ARG 1159 0.0123

ARG 1159 SER 1160 0.0246

SER 1160 VAL 1161 0.0419

VAL 1161 ASP 1162 0.0117

ASP 1162 PRO 1163 0.0604

PRO 1163 SER 1164 0.0120

SER 1164 ASN 1165 0.1250

ASN 1165 LEU 1166 0.0149

LEU 1166 TYR 1167 0.0269

TYR 1167 SER 1168 0.0304

SER 1168 PHE 1169 0.0080

PHE 1169 LEU 1170 0.0329

LEU 1170 ARG 1171 0.0139

ARG 1171 ALA 1172 0.0380

ALA 1172 GLN 1173 0.0048

GLN 1173 GLY 1174 0.0341

GLY 1174 ILE 1175 0.0384

ILE 1175 TYR 1176 0.0074

TYR 1176 HIS 1177 0.0385

HIS 1177 GLY 1178 0.0054

GLY 1178 PRO 1179 0.0302

PRO 1179 ILE 1180 0.0296

ILE 1180 PHE 1181 0.0004

PHE 1181 GLN 1182 0.0441

GLN 1182 ASN 1183 0.0444

ASN 1183 LEU 1184 0.0363

LEU 1184 LYS 1185 0.0376

LYS 1185 THR 1186 0.0284

THR 1186 ILE 1187 0.0151

ILE 1187 SER 1188 0.0293

SER 1188 SER 1189 0.0196

SER 1189 ARG 1190 0.0159

ARG 1190 LYS 1191 0.0232

LYS 1191 ASP 1192 0.0370

ASP 1192 HIS 1193 0.0297

HIS 1193 SER 1194 0.0045

SER 1194 GLU 1195 0.0303

GLU 1195 SER 1196 0.0184

SER 1196 SER 1197 -0.0843

SER 1197 PHE 1198 0.0562

PHE 1198 VAL 1199 0.0397

VAL 1199 VAL 1200 0.0608

VAL 1200 ALA 1201 0.0488

ALA 1201 ASN 1202 0.0347

ASN 1202 THR 1203 0.0442

THR 1203 ALA 1204 0.0469

ALA 1204 SER 1205 0.0227

SER 1205 VAL 1206 0.0531

VAL 1206 MET 1207 0.0541

MET 1207 PRO 1208 0.0468

PRO 1208 ASN 1209 0.0354

ASN 1209 GLY 1210 0.0556

GLY 1210 PHE 1211 0.0281

PHE 1211 GLN 1212 0.0107

GLN 1212 SER 1213 0.0934

SER 1213 PRO 1214 0.0542

PRO 1214 HIS 1215 0.0257

HIS 1215 VAL 1216 0.0400

VAL 1216 ILE 1217 0.0555

ILE 1217 HIS 1218 0.0460

HIS 1218 PRO 1219 0.0429

PRO 1219 THR 1220 0.0283

THR 1220 THR 1221 0.0561

THR 1221 LEU 1222 0.0003

LEU 1222 ASP 1223 0.0566

ASP 1223 SER 1224 0.0353

SER 1224 ILE 1225 0.0268

ILE 1225 PHE 1226 0.0351

PHE 1226 GLN 1227 0.0323

GLN 1227 GLY 1228 0.0569

GLY 1228 ALA 1229 0.1526

ALA 1229 TYR 1230 0.0407

TYR 1230 THR 1231 0.0366

THR 1231 ALA 1232 0.0079

ALA 1232 LEU 1233 0.0351

LEU 1233 PRO 1234 0.0407

PRO 1234 GLY 1235 0.0090

GLY 1235 ALA 1236 0.0347

ALA 1236 GLY 1237 0.0379

GLY 1237 LEU 1238 0.0329

LEU 1238 ASP 1239 0.0103

ASP 1239 GLN 1240 0.0380

GLN 1240 ASN 1241 0.0365

ASN 1241 THR 1242 0.0399

THR 1242 ALA 1243 0.0272

ALA 1243 MET 1244 0.0339

MET 1244 ILE 1245 0.0132

ILE 1245 PRO 1246 0.0471

PRO 1246 ARG 1247 0.0085

ARG 1247 SER 1248 0.0466

SER 1248 ILE 1249 0.0396

ILE 1249 GLN 1250 0.0331

GLN 1250 GLU 1251 0.0213

GLU 1251 LEU 1252 0.0019

LEU 1252 TYR 1253 0.0282

TYR 1253 LEU 1254 0.0034

LEU 1254 SER 1255 0.0289

SER 1255 SER 1256 0.0256

SER 1256 ALA 1257 0.0293

ALA 1257 LEU 1258 0.0473

LEU 1258 THR 1259 0.0104

THR 1259 SER 1260 0.0472

SER 1260 ASP 1261 0.0305

ASP 1261 VAL 1262 0.0495

VAL 1262 GLY 1263 0.0524

GLY 1263 GLN 1264 0.0325

GLN 1264 CYS 1265 0.0293

CYS 1265 LEU 1266 0.0049

LEU 1266 VAL 1267 0.0225

VAL 1267 SER 1268 0.0114

SER 1268 ASP 1269 0.0142

ASP 1269 THR 1270 0.0301

THR 1270 SER 1271 0.0025

SER 1271 LEU 1272 0.0352

LEU 1272 ILE 1273 0.0173

ILE 1273 ARG 1274 0.0472

ARG 1274 TYR 1275 0.0510

TYR 1275 ASP 1276 0.0388

ASP 1276 GLY 1277 0.0377

GLY 1277 GLN 1278 0.0479

GLN 1278 SER 1279 0.0475

SER 1279 PHE 1280 0.0462

PHE 1280 THR 1281 0.0491

THR 1281 VAL 1282 0.0319

VAL 1282 ASN 1283 0.0446

ASN 1283 VAL 1284 0.0015

VAL 1284 ASP 1285 0.0389

ASP 1285 VAL 1286 -0.0001

VAL 1286 SER 1287 0.0315

SER 1287 SER 1288 0.0017

SER 1288 LYS 1289 0.0471

LYS 1289 ALA 1290 0.0302

ALA 1290 ASP 1291 0.0238

ASP 1291 SER 1292 0.0426

SER 1292 GLU 1293 0.0234

GLU 1293 HIS 1294 0.0491

HIS 1294 THR 1295 0.0510

THR 1295 PRO 1296 0.0445

PRO 1296 VAL 1297 0.0401

VAL 1297 LEU 1298 0.0274

LEU 1298 GLU 1299 0.0026

GLU 1299 ILE 1300 0.0303

ILE 1300 LYS 1301 0.0027

LYS 1301 GLY 1302 0.0316

GLY 1302 LEU 1303 0.0360

LEU 1303 ARG 1304 0.0314

ARG 1304 ASN 1305 0.0508

ASN 1305 GLN 1306 0.0353

GLN 1306 SER 1307 0.0556

SER 1307 VAL 1308 0.0510

VAL 1308 GLY 1309 0.1461

GLY 1309 GLN 1310 0.0326

GLN 1310 MET 1311 0.0309

MET 1311 ALA 1312 0.0242

ALA 1312 PRO 1313 0.0203

PRO 1313 GLN 1314 0.0311

GLN 1314 PRO 1315 0.0275

PRO 1315 GLY 1316 0.0157

GLY 1316 ASP 1317 0.0302

ASP 1317 SER 1318 0.0170

SER 1318 SER 1319 0.0231

SER 1319 ASN 1320 0.0329

ASN 1320 ASN 1321 0.0144

ASN 1321 ASP 1322 0.0314

ASP 1322 LEU 1323 0.0152

LEU 1323 CYS 1324 0.0318

CYS 1324 PHE 1325 0.0005

PHE 1325 LYS 1326 0.0008

LYS 1326 LEU 1327 0.0104

LEU 1327 ASP 1328 0.0136

ASP 1328 TRP 1329 0.0062

TRP 1329 ALA 1330 0.0160

ALA 1330 PRO 1331 0.0100

PRO 1331 ASP 1332 0.0153

ASP 1332 ILE 1333 0.0171

ILE 1333 SER 1334 0.0169

SER 1334 SER 1335 0.0030

SER 1335 VAL 1336 0.0152

VAL 1336 LYS 1337 0.0040

LYS 1337 GLN 1338 0.0170

GLN 1338 GLU 1339 0.0052

GLU 1339 ARG 1340 0.0136

ARG 1340 LEU 1341 -0.0331

LEU 1341 LYS 1342 0.0117

LYS 1342 GLU 1343 0.0163

GLU 1343 LYS 1344 0.0077

LYS 1344 PHE 1345 0.0198

PHE 1345 GLY 1346 0.0065

GLY 1346 PHE 1347 0.0233

PHE 1347 PRO 1348 0.0186

PRO 1348 LEU 1349 0.0131

LEU 1349 ASP 1350 0.0197

ASP 1350 PRO 1351 0.0148

PRO 1351 THR 1352 0.0215

THR 1352 GLU 1353 0.0219

GLU 1353 ALA 1354 0.0051

ALA 1354 ASP 1355 0.0230

ASP 1355 ILE 1356 0.0218

ILE 1356 ILE 1357 0.2200

ILE 1357 MET 1358 0.0299

MET 1358 GLY 1359 0.0648

GLY 1359 LEU 1360 0.0649

LEU 1360 ARG 1361 0.0279

ARG 1361 GLN 1362 0.0504

GLN 1362 ALA 1363 0.0625

ALA 1363 CYS 1364 0.0582

CYS 1364 ILE 1365 0.0182

ILE 1365 HIS 1366 0.0637

HIS 1366 PHE 1367 0.0640

PHE 1367 ILE 1368 0.0432

ILE 1368 HIS 1369 0.0321

HIS 1369 ARG 1370 0.0648

ARG 1370 SER 1371 0.0650

SER 1371 LEU 1372 0.0297

LEU 1372 GLN 1373 0.0617

GLN 1373 SER 1374 0.0713

SER 1374 LEU 1375 0.0754

LEU 1375 THR 1376 0.0208

THR 1376 ALA 1377 0.0604

ALA 1377 PRO 1378 0.0676

PRO 1378 ASP 1379 0.0110

ASP 1379 ARG 1380 0.0753

ARG 1380 ASP 1381 0.0687

ASP 1381 GLN 1382 0.0295

GLN 1382 LEU 1383 0.0435

LEU 1383 ASP 1384 0.0437

ASP 1384 TRP 1385 0.0759

TRP 1385 HIS 1386 0.0339

HIS 1386 GLN 1387 0.0627

GLN 1387 LYS 1388 0.0280

LYS 1388 ARG 1389 0.0381

ARG 1389 PHE 1390 0.0602

PHE 1390 TYR 1391 0.0162

TYR 1391 ASP 1392 0.0693

ASP 1392 TRP 1393 0.0223

TRP 1393 MET 1394 0.0756

MET 1394 VAL 1395 0.0113

VAL 1395 LEU 1396 0.0680

LEU 1396 GLN 1397 0.0411

GLN 1397 ILE 1398 0.0406

ILE 1398 GLN 1399 0.0555

GLN 1399 LEU 1400 0.0280

LEU 1400 ALA 1401 0.0745

ALA 1401 GLU 1402 0.0092

GLU 1402 GLU 1403 0.0759

GLU 1403 ASP 1404 0.0253

ASP 1404 ARG 1405 0.1156

ARG 1405 LEU 1406 0.0422

LEU 1406 ALA 1407 0.0824

ALA 1407 PRO 1408 0.0756

PRO 1408 ASN 1409 0.0597

ASN 1409 SER 1410 0.0888

SER 1410 SER 1411 0.0090

SER 1411 ALA 1412 0.0826

ALA 1412 TRP 1413 0.0585

TRP 1413 LEU 1414 0.0333

LEU 1414 GLN 1415 0.0851

GLN 1415 CYS 1416 0.0264

CYS 1416 SER 1417 0.0901

SER 1417 SER 1418 0.0763

SER 1418 SER 1419 0.0465

SER 1419 ASP 1420 0.0854

ASP 1420 GLU 1421 0.1527

GLU 1421 GLN 1422 0.0428

GLN 1422 LYS 1423 0.0486

LYS 1423 LEU 1424 0.0759

LEU 1424 LEU 1425 0.0750

LEU 1425 GLU 1426 0.0266

GLU 1426 ASN 1427 0.0698

ASN 1427 VAL 1428 0.0743

VAL 1428 ARG 1429 0.0626

ARG 1429 ALA 1430 0.0274

ALA 1430 SER 1431 0.0774

SER 1431 SER 1432 0.0765

SER 1432 VAL 1433 0.0776

VAL 1433 ASN 1434 0.0191

ASN 1434 GLY 1435 0.0676

GLY 1435 GLN 1436 0.0666

GLN 1436 MET 1437 0.0515

MET 1437 VAL 1438 0.0154

VAL 1438 VAL 1439 0.0691

VAL 1439 HIS 1440 0.0635

HIS 1440 VAL 1441 0.0486

VAL 1441 GLY 1442 0.0307

GLY 1442 LYS 1443 0.0696

LYS 1443 SER 1444 0.0704

SER 1444 MET 1445 0.0507

MET 1445 LEU 1446 0.0201

LEU 1446 ALA 1447 0.0551

ALA 1447 ILE 1448 0.0599

ILE 1448 LEU 1449 0.0146

LEU 1449 ARG 1450 0.0633

ARG 1450 HIS 1451 0.0308

HIS 1451 GLU 1452 0.0620

GLU 1452 ILE 1453 -0.0196

ILE 1453 ALA 1454 0.0460

ALA 1454 PRO 1455 0.0535

PRO 1455 LEU 1456 0.0147

LEU 1456 GLU 1457 0.0385

GLU 1457 LEU 1458 0.0427

LEU 1458 MET 1459 0.0514

MET 1459 LEU 1460 0.0048

LEU 1460 GLN 1461 0.0538

GLN 1461 ASP 1462 0.0346

ASP 1462 LYS 1463 0.0531

LYS 1463 LEU 1464 0.0133

LEU 1464 LEU 1465 0.0521

LEU 1465 TYR 1466 0.0118

TYR 1466 ARG 1467 0.0524

ARG 1467 TYR 1468 0.0095

TYR 1468 TYR 1469 -0.0227

TYR 1469 THR 1470 0.0092

THR 1470 ASP 1471 0.0192

ASP 1471 ALA 1472 0.0013

ALA 1472 ILE 1473 0.0192

ILE 1473 LYS 1474 0.0217

LYS 1474 TRP 1475 0.0126

TRP 1475 ASP 1476 0.0062

ASP 1476 ARG 1477 0.0197

ARG 1477 SER 1478 0.0206

SER 1478 TYR 1479 0.0049

TYR 1479 GLN 1480 0.0168

GLN 1480 GLN 1481 0.0167

GLN 1481 ILE 1482 0.0199

ILE 1482 ASP 1483 0.0027

ASP 1483 GLN 1484 0.0215

GLN 1484 LEU 1485 -0.0083

LEU 1485 VAL 1486 0.0020

VAL 1486 LYS 1487 0.0010

LYS 1487 LEU 1488 0.0024

LEU 1488 HIS 1489 0.0026

HIS 1489 ALA 1490 0.0015

ALA 1490 HIS 1491 0.0013

HIS 1491 LYS 1492 0.0027

LYS 1492 CYS 1493 0.0028

CYS 1493 PRO 1494 0.0021

PRO 1494 THR 1495 0.0025

THR 1495 ALA 1496 0.0000

ALA 1496 LYS 1497 0.0020

LYS 1497 ILE 1498 0.0008

ILE 1498 ILE 1499 0.0005

ILE 1499 GLU 1500 0.0012

GLU 1500 ILE 1501 -0.0146

ILE 1501 GLY 1502 0.0085

GLY 1502 ALA 1503 0.0039

ALA 1503 GLY 1504 0.0080

GLY 1504 THR 1505 0.0086

THR 1505 GLY 1506 0.0044

GLY 1506 GLY 1507 0.0103

GLY 1507 CYS 1508 0.0101

CYS 1508 THR 1509 0.0060

THR 1509 ARG 1510 0.0076

ARG 1510 ALA 1511 0.0110

ALA 1511 VAL 1512 0.0107

VAL 1512 LEU 1513 0.0056

LEU 1513 ASP 1514 0.0090

ASP 1514 ALA 1515 0.0108

ALA 1515 LEU 1516 0.0095

LEU 1516 SER 1517 -0.0125

SER 1517 ASN 1518 0.0016

ASN 1518 GLN 1519 0.0043

GLN 1519 GLY 1520 0.0037

GLY 1520 ILE 1521 0.0034

ILE 1521 ALA 1522 0.0025

ALA 1522 ARG 1523 0.0042

ARG 1523 CYS 1524 0.0033

CYS 1524 ALA 1525 0.0040

ALA 1525 GLN 1526 0.0007

GLN 1526 TYR 1527 0.0006

TYR 1527 ASP 1528 0.0017

ASP 1528 PHE 1529 0.0017

PHE 1529 THR 1530 0.0013

THR 1530 ASP 1531 0.0001

ASP 1531 VAL 1532 0.0017

VAL 1532 SER 1533 0.1263

SER 1533 SER 1534 0.0011

SER 1534 GLY 1535 0.0084

GLY 1535 PHE 1536 0.0067

PHE 1536 PHE 1537 0.0031

PHE 1537 GLU 1538 0.0062

GLU 1538 ALA 1539 0.0086

ALA 1539 ALA 1540 0.0083

ALA 1540 GLN 1541 0.0027

GLN 1541 GLN 1542 0.0081

GLN 1542 LYS 1543 0.0082

LYS 1543 PHE 1544 0.0072

PHE 1544 ALA 1545 0.0031

ALA 1545 ALA 1546 0.0062

ALA 1546 PHE 1547 0.0075

PHE 1547 ASP 1548 0.0089

ASP 1548 ASP 1549 0.0142

ASP 1549 VAL 1550 0.0056

VAL 1550 ILE 1551 0.0006

ILE 1551 ARG 1552 0.0053

ARG 1552 PHE 1553 0.0007

PHE 1553 GLN 1554 0.0043

GLN 1554 LYS 1555 0.0002

LYS 1555 LEU 1556 0.0067

LEU 1556 ASP 1557 0.0009

ASP 1557 ILE 1558 0.0070

ILE 1558 GLU 1559 0.0021

GLU 1559 LYS 1560 0.0062

LYS 1560 ASP 1561 0.0036

ASP 1561 ILE 1562 0.0011

ILE 1562 GLU 1563 0.0050

GLU 1563 MET 1564 0.0041

MET 1564 GLN 1565 0.0543

GLN 1565 GLY 1566 0.0016

GLY 1566 PHE 1567 0.0095

PHE 1567 GLU 1568 0.0092

GLU 1568 CYS 1569 0.0047

CYS 1569 GLY 1570 0.0097

GLY 1570 SER 1571 0.0036

SER 1571 TYR 1572 0.0088

TYR 1572 ASP 1573 0.0099

ASP 1573 LEU 1574 0.0063

LEU 1574 VAL 1575 0.0053

VAL 1575 ILE 1576 0.0088

ILE 1576 ALA 1577 0.0029

ALA 1577 SER 1578 0.0087

SER 1578 GLN 1579 0.0024

GLN 1579 VAL 1580 0.0098

VAL 1580 LEU 1581 -0.0436

LEU 1581 HIS 1582 0.0004

HIS 1582 ALA 1583 0.0107

ALA 1583 THR 1584 0.0095

THR 1584 GLY 1585 0.0097

GLY 1585 LYS 1586 0.0108

LYS 1586 MET 1587 0.0108

MET 1587 GLU 1588 0.0090

GLU 1588 HIS 1589 0.0063

HIS 1589 THR 1590 0.0111

THR 1590 MET 1591 0.0109

MET 1591 ALA 1592 0.0070

ALA 1592 ASN 1593 0.0075

ASN 1593 VAL 1594 0.0110

VAL 1594 ARG 1595 0.0100

ARG 1595 LYS 1596 0.0036

LYS 1596 LEU 1597 -0.0734

LEU 1597 LEU 1598 0.0071

LEU 1598 LYS 1599 0.0056

LYS 1599 PRO 1600 0.0047

PRO 1600 GLY 1601 0.0070

GLY 1601 GLY 1602 0.0064

GLY 1602 LYS 1603 0.0055

LYS 1603 LEU 1604 0.0048

LEU 1604 LEU 1605 0.0070

LEU 1605 LEU 1606 0.0031

LEU 1606 VAL 1607 0.0069

VAL 1607 GLU 1608 0.0015

GLU 1608 THR 1609 0.0027

THR 1609 THR 1610 0.0039

THR 1610 ARG 1611 0.0040

ARG 1611 ASP 1612 0.0072

ASP 1612 GLU 1613 -0.0020

GLU 1613 MET 1614 0.0227

MET 1614 ASP 1615 0.0285

ASP 1615 LEU 1616 0.0350

LEU 1616 GLN 1617 0.0128

GLN 1617 LEU 1618 0.0384

LEU 1618 VAL 1619 0.0163

VAL 1619 PHE 1620 0.0438

PHE 1620 GLY 1621 0.0059

GLY 1621 LEU 1622 0.0440

LEU 1622 LEU 1623 0.0267

LEU 1623 PRO 1624 0.0415

PRO 1624 GLY 1625 0.0161

GLY 1625 TRP 1626 0.0404

TRP 1626 TRP 1627 0.0171

TRP 1627 LEU 1628 0.0381

LEU 1628 SER 1629 0.2109

SER 1629 SER 1630 0.0220

SER 1630 GLU 1631 0.0251

GLU 1631 GLU 1632 0.0034

GLU 1632 GLU 1633 0.0239

GLU 1633 ARG 1634 0.0215

ARG 1634 GLN 1635 0.0123

GLN 1635 MET 1636 0.0207

MET 1636 SER 1637 0.0062

SER 1637 PRO 1638 0.0022

PRO 1638 SER 1639 0.0232

SER 1639 LEU 1640 0.0242

LEU 1640 SER 1641 0.0243

SER 1641 THR 1642 0.0092

THR 1642 ASN 1643 0.0222

ASN 1643 SER 1644 0.0251

SER 1644 TRP 1645 0.0097

TRP 1645 GLU 1646 0.0079

GLU 1646 LYS 1647 0.0081

LYS 1647 VAL 1648 0.0065

VAL 1648 LEU 1649 0.0032

LEU 1649 LYS 1650 0.0085

LYS 1650 LYS 1651 0.0083

LYS 1651 THR 1652 0.0043

THR 1652 GLY 1653 0.0038

GLY 1653 PHE 1654 0.0081

PHE 1654 ASP 1655 0.0083

ASP 1655 GLY 1656 0.0021

GLY 1656 LEU 1657 0.0078

LEU 1657 ASP 1658 0.0054

ASP 1658 ILE 1659 0.0065

ILE 1659 GLU 1660 0.0018

GLU 1660 LEU 1661 0.0074

LEU 1661 ARG 1662 0.0130

ARG 1662 ASP 1663 0.0176

ASP 1663 CYS 1664 0.0171

CYS 1664 ASP 1665 0.0169

ASP 1665 SER 1666 0.0040

SER 1666 ASP 1667 0.0060

ASP 1667 GLU 1668 0.0173

GLU 1668 PHE 1669 0.0075

PHE 1669 TYR 1670 0.0143

TYR 1670 SER 1671 0.0196

SER 1671 PHE 1672 0.0078

PHE 1672 SER 1673 0.0183

SER 1673 VAL 1674 0.0038

VAL 1674 MET 1675 0.0186

MET 1675 MET 1676 0.0130

MET 1676 ALA 1677 0.0464

ALA 1677 THR 1678 0.1058

THR 1678 ALA 1679 0.1069

ALA 1679 SER 1680 0.1129

SER 1680 SER 1681 0.0771

SER 1681 THR 1682 0.1167

THR 1682 ILE 1683 0.0663

ILE 1683 ALA 1684 0.1186

ALA 1684 SER 1685 0.1208

SER 1685 SER 1686 0.0217

SER 1686 SER 1687 0.1189

SER 1687 MET 1688 0.0213

MET 1688 ALA 1689 0.0989

ALA 1689 PHE 1690 0.1011

PHE 1690 ALA 1691 0.0603

ALA 1691 ILE 1692 0.1114

ILE 1692 VAL 1693 0.2178

VAL 1693 TYR 1694 0.0768

TYR 1694 GLY 1695 0.0214

GLY 1695 GLU 1696 0.0582

GLU 1696 VAL 1697 0.0386

VAL 1697 PRO 1698 0.0426

PRO 1698 LEU 1699 0.0110

LEU 1699 PRO 1700 0.0528

PRO 1700 ASP 1701 0.0708

ASP 1701 GLN 1702 0.0140

GLN 1702 PHE 1703 0.0828

PHE 1703 LEU 1704 0.0734

LEU 1704 ASP 1705 0.0346

ASP 1705 ASP 1706 0.0515

ASP 1706 MET 1707 0.0626

MET 1707 LYS 1708 0.0850

LYS 1708 THR 1709 -0.0041

THR 1709 ALA 1710 0.0849

ALA 1710 ILE 1711 0.0619

ILE 1711 SER 1712 0.0676

SER 1712 SER 1713 0.0216

SER 1713 SER 1714 0.0770

SER 1714 ALA 1715 0.0634

ALA 1715 VAL 1716 0.0838

VAL 1716 SER 1717 0.0309

SER 1717 ASP 1718 0.0771

ASP 1718 PRO 1719 0.0267

PRO 1719 VAL 1720 0.0220

VAL 1720 VAL 1721 0.0701

VAL 1721 GLY 1722 0.0006

GLY 1722 HIS 1723 0.0274

HIS 1723 LEU 1724 0.0676

LEU 1724 ASP 1725 0.0522

ASP 1725 SER 1726 0.0622

SER 1726 ILE 1727 0.0265

ILE 1727 ASP 1728 0.0812

ASP 1728 ALA 1729 0.0682

ALA 1729 THR 1730 0.0820

THR 1730 GLY 1731 0.0222

GLY 1731 LYS 1732 0.0671

LYS 1732 PHE 1733 0.0713

PHE 1733 CYS 1734 0.0619

CYS 1734 ILE 1735 0.0779

ILE 1735 PHE 1736 0.0235

PHE 1736 ILE 1737 0.0806

ILE 1737 GLU 1738 0.0283

GLU 1738 ASP 1739 0.0801

ASP 1739 PRO 1740 0.0818

PRO 1740 GLU 1741 0.1077

GLU 1741 THR 1742 0.0514

THR 1742 ASP 1743 0.0841

ASP 1743 ILE 1744 0.0654

ILE 1744 LEU 1745 0.0841

LEU 1745 SER 1746 0.0776

SER 1746 SER 1747 0.0240

SER 1747 PRO 1748 0.0851

PRO 1748 ASP 1749 0.0409

ASP 1749 GLU 1750 0.0713

GLU 1750 LYS 1751 0.0633

LYS 1751 SER 1752 0.0175

SER 1752 TYR 1753 0.0837

TYR 1753 ALA 1754 0.0807

ALA 1754 SER 1755 0.0334

SER 1755 ILE 1756 0.0567

ILE 1756 GLN 1757 0.0886

GLN 1757 LYS 1758 0.0657

LYS 1758 LEU 1759 0.0105

LEU 1759 VAL 1760 0.0688

VAL 1760 THR 1761 0.0574

THR 1761 ARG 1762 0.0566

ARG 1762 CYS 1763 0.0113

CYS 1763 LYS 1764 0.0323

LYS 1764 GLY 1765 0.0651

GLY 1765 LEU 1766 0.0695

LEU 1766 ILE 1767 0.0535

ILE 1767 TRP 1768 0.0401

TRP 1768 VAL 1769 0.0578

VAL 1769 SER 1770 0.0634

SER 1770 ARG 1771 0.0664

ARG 1771 GLY 1772 0.0707

GLY 1772 GLY 1773 0.0424

GLY 1773 ALA 1774 0.0266

ALA 1774 MET 1775 0.0278

MET 1775 HIS 1776 0.0445

HIS 1776 GLY 1777 0.0061

GLY 1777 THR 1778 0.0504

THR 1778 ARG 1779 0.0221

ARG 1779 PRO 1780 0.0360

PRO 1780 ASN 1781 0.0345

ASN 1781 SER 1782 0.0181

SER 1782 SER 1783 0.0501

SER 1783 LEU 1784 0.0139

LEU 1784 LYS 1785 0.0392

LYS 1785 THR 1786 0.0271

THR 1786 GLY 1787 0.0247

GLY 1787 LEU 1788 0.0415

LEU 1788 LEU 1789 -0.0174

LEU 1789 ARG 1790 0.0604

ARG 1790 THR 1791 0.0126

THR 1791 LEU 1792 0.0620

LEU 1792 ARG 1793 0.0187

ARG 1793 LEU 1794 0.0439

LEU 1794 GLU 1795 0.0287

GLU 1795 TYR 1796 0.0416

TYR 1796 THR 1797 0.0228

THR 1797 GLU 1798 0.0575

GLU 1798 LYS 1799 0.0623

LYS 1799 ARG 1800 0.0287

ARG 1800 PHE 1801 0.0538

PHE 1801 ILE 1802 0.0329

ILE 1802 SER 1803 0.0615

SER 1803 LEU 1804 0.0334

LEU 1804 ASP 1805 0.0208

ASP 1805 LEU 1806 0.0592

LEU 1806 ASP 1807 0.0868

ASP 1807 SER 1808 0.0458

SER 1808 ALA 1809 0.0551

ALA 1809 ARG 1810 0.0660

ARG 1810 PRO 1811 0.0892

PRO 1811 GLN 1812 0.0578

GLN 1812 TRP 1813 0.0651

TRP 1813 ASN 1814 0.0065

ASN 1814 HIS 1815 0.0383

HIS 1815 ASP 1816 0.0925

ASP 1816 SER 1817 0.0150

SER 1817 ILE 1818 0.0839

ILE 1818 THR 1819 0.0393

THR 1819 THR 1820 0.0598

THR 1820 ILE 1821 -0.0104

ILE 1821 ASN 1822 0.0265

ASN 1822 GLU 1823 0.0546

GLU 1823 VAL 1824 0.0106

VAL 1824 LEU 1825 0.0597

LEU 1825 CYS 1826 0.0127

CYS 1826 GLY 1827 0.0543

GLY 1827 ALA 1828 0.0194

ALA 1828 LEU 1829 0.0424

LEU 1829 ALA 1830 0.0229

ALA 1830 GLN 1831 0.0454

GLN 1831 ASN 1832 0.0579

ASN 1832 ALA 1833 0.0358

ALA 1833 ASP 1834 0.0565

ASP 1834 SER 1835 0.0587

SER 1835 SER 1836 0.0146

SER 1836 ILE 1837 -0.0504

ILE 1837 LYS 1838 0.0520

LYS 1838 ASP 1839 0.0520

ASP 1839 SER 1840 0.0296

SER 1840 GLU 1841 0.0517

GLU 1841 PHE 1842 0.0172

PHE 1842 ALA 1843 0.0500

ALA 1843 GLU 1844 0.0176

GLU 1844 GLN 1845 0.0469

GLN 1845 ASP 1846 0.0131

ASP 1846 GLY 1847 0.0484

GLY 1847 GLN 1848 0.0506

GLN 1848 LEU 1849 0.0259

LEU 1849 PHE 1850 0.0322

PHE 1850 VAL 1851 0.0314

VAL 1851 PRO 1852 0.0189

PRO 1852 ARG 1853 0.1295

ARG 1853 ILE 1854 0.0229

ILE 1854 SER 1855 0.0394

SER 1855 CYS 1856 0.0275

CYS 1856 ASP 1857 0.0144

ASP 1857 ILE 1858 0.0382

ILE 1858 ALA 1859 0.0177

ALA 1859 ARG 1860 0.0216

ARG 1860 ASN 1861 0.0339

ASN 1861 GLU 1862 0.0394

GLU 1862 ASP 1863 0.0040

ASP 1863 LEU 1864 0.0379

LEU 1864 SER 1865 0.0313

SER 1865 SER 1866 0.0338

SER 1866 ASP 1867 0.0185

ASP 1867 SER 1868 0.0213

SER 1868 ASN 1869 0.6420

ASN 1869 SER 1870 0.0418

SER 1870 PRO 1871 0.0152

PRO 1871 ALA 1872 0.0240

ALA 1872 GLN 1873 0.0422

GLN 1873 MET 1874 0.0088

MET 1874 GLU 1875 0.0427

GLU 1875 PRO 1876 0.0244

PRO 1876 PHE 1877 0.0393

PHE 1877 HIS 1878 0.0431

HIS 1878 GLN 1879 0.0056

GLN 1879 PRO 1880 0.0394

PRO 1880 GLY 1881 0.0216

GLY 1881 LYS 1882 0.0429

LYS 1882 LEU 1883 0.0365

LEU 1883 LEU 1884 0.0370

LEU 1884 GLN 1885 -0.1047

GLN 1885 MET 1886 0.0265

MET 1886 GLY 1887 0.0448

GLY 1887 ILE 1888 0.0406

ILE 1888 LYS 1889 0.0458

LYS 1889 THR 1890 0.0456

THR 1890 PRO 1891 0.0483

PRO 1891 GLY 1892 0.0119

GLY 1892 LEU 1893 0.0389

LEU 1893 ILE 1894 0.0420

ILE 1894 ASP 1895 0.0453

ASP 1895 THR 1896 0.0023

THR 1896 LEU 1897 0.0487

LEU 1897 GLN 1898 0.0376

GLN 1898 PHE 1899 0.0329

PHE 1899 SER 1900 0.0063

SER 1900 LYS 1901 0.1028

LYS 1901 THR 1902 0.0048

THR 1902 ASP 1903 0.0141

ASP 1903 ALA 1904 0.0146

ALA 1904 THR 1905 0.0053

THR 1905 ASP 1906 0.0132

ASP 1906 ASN 1907 0.0058

ASN 1907 LEU 1908 0.0153

LEU 1908 PRO 1909 0.0029

PRO 1909 ASN 1910 0.0152

ASN 1910 ASP 1911 0.0154

ASP 1911 TYR 1912 0.0069

TYR 1912 ILE 1913 0.0005

ILE 1913 GLU 1914 0.0077

GLU 1914 ILE 1915 0.0071

ILE 1915 GLU 1916 0.0039

GLU 1916 PRO 1917 -0.1466

PRO 1917 LYS 1918 0.0072

LYS 1918 ALA 1919 0.0454

ALA 1919 PHE 1920 0.0474

PHE 1920 GLY 1921 0.0486

GLY 1921 LEU 1922 0.0484

LEU 1922 ASN 1923 0.0468

ASN 1923 PHE 1924 0.0487

PHE 1924 ARG 1925 0.0052

ARG 1925 ASP 1926 0.0510

ASP 1926 VAL 1927 0.0235

VAL 1927 MET 1928 0.0373

MET 1928 VAL 1929 0.0255

VAL 1929 ALA 1930 0.0305

ALA 1930 MET 1931 0.0461

MET 1931 GLY 1932 0.0081

GLY 1932 GLN 1933 -0.0830

GLN 1933 LEU 1934 0.0142

LEU 1934 GLU 1935 0.0160

GLU 1935 GLU 1936 0.0606

GLU 1936 SER 1937 0.0565

SER 1937 ILE 1938 0.0654

ILE 1938 MET 1939 0.0290

MET 1939 GLY 1940 0.0655

GLY 1940 PHE 1941 0.0548

PHE 1941 GLU 1942 0.0622

GLU 1942 CYS 1943 0.0634

CYS 1943 ALA 1944 0.0656

ALA 1944 GLY 1945 0.0583

GLY 1945 VAL 1946 0.0406

VAL 1946 VAL 1947 0.0009

VAL 1947 ARG 1948 0.0611

ARG 1948 ARG 1949 0.0475

ARG 1949 VAL 1950 0.0113

VAL 1950 GLY 1951 0.0026

GLY 1951 PRO 1952 0.0168

PRO 1952 SER 1953 0.0239

SER 1953 SER 1954 0.0056

SER 1954 ALA 1955 0.0250

ALA 1955 GLY 1956 0.0178

GLY 1956 HIS 1957 0.0209

HIS 1957 ASN 1958 0.0073

ASN 1958 ILE 1959 0.0222

ILE 1959 LYS 1960 0.0227

LYS 1960 VAL 1961 0.0201

VAL 1961 GLY 1962 0.0021

GLY 1962 ASP 1963 0.0270

ASP 1963 ARG 1964 0.0171

ARG 1964 VAL 1965 0.0414

VAL 1965 CYS 1966 0.0338

CYS 1966 ALA 1967 0.0098

ALA 1967 LEU 1968 0.0234

LEU 1968 LEU 1969 0.0327

LEU 1969 GLY 1970 0.0119

GLY 1970 GLY 1971 0.0207

GLY 1971 GLN 1972 0.0237

GLN 1972 TRP 1973 0.0012

TRP 1973 THR 1974 0.0344

THR 1974 ASN 1975 0.0206

ASN 1975 THR 1976 0.0160

THR 1976 VAL 1977 0.0204

VAL 1977 ARG 1978 0.0060

ARG 1978 VAL 1979 0.0288

VAL 1979 HIS 1980 0.0165

HIS 1980 TRP 1981 0.1756

TRP 1981 HIS 1982 0.0527

HIS 1982 SER 1983 0.0179

SER 1983 VAL 1984 0.0343

VAL 1984 ALA 1985 0.0428

ALA 1985 PRO 1986 0.0334

PRO 1986 ILE 1987 0.0065

ILE 1987 PRO 1988 0.0371

PRO 1988 GLN 1989 0.0361

GLN 1989 ALA 1990 0.0186

ALA 1990 MET 1991 0.0514

MET 1991 ASP 1992 0.0437

ASP 1992 TRP 1993 0.0412

TRP 1993 GLU 1994 0.0470

GLU 1994 THR 1995 0.0501

THR 1995 ALA 1996 0.0132

ALA 1996 ALA 1997 0.0648

ALA 1997 SER 1998 0.0630

SER 1998 ILE 1999 0.0265

ILE 1999 PRO 2000 0.0143

PRO 2000 ILE 2001 0.0612

ILE 2001 VAL 2002 0.0506

VAL 2002 PHE 2003 0.0572

PHE 2003 VAL 2004 0.0111

VAL 2004 THR 2005 0.0641

THR 2005 ALA 2006 0.0588

ALA 2006 TYR 2007 0.0457

TYR 2007 ILE 2008 0.0193

ILE 2008 SER 2009 0.0624

SER 2009 LEU 2010 0.0600

LEU 2010 VAL 2011 0.0549

VAL 2011 LYS 2012 0.0207

LYS 2012 ILE 2013 0.0033

ILE 2013 ALA 2014 0.0936

ALA 2014 ARG 2015 0.1092

ARG 2015 MET 2016 0.0429

MET 2016 GLN 2017 0.1126

GLN 2017 ALA 2018 0.0574

ALA 2018 GLY 2019 0.1035

GLY 2019 GLU 2020 0.1034

GLU 2020 THR 2021 0.0701

THR 2021 VAL 2022 0.1083

VAL 2022 LEU 2023 0.0894

LEU 2023 ILE 2024 0.0943

ILE 2024 HIS 2025 0.1019

HIS 2025 ALA 2026 0.0489

ALA 2026 ALA 2027 0.1094

ALA 2027 SER 2028 0.0308

SER 2028 GLY 2029 0.0281

GLY 2029 GLY 2030 0.0812

GLY 2030 VAL 2031 0.0169

VAL 2031 GLY 2032 0.0822

GLY 2032 GLN 2033 0.0627

GLN 2033 ALA 2034 0.0460

ALA 2034 ALA 2035 0.0679

ALA 2035 ILE 2036 0.0466

ILE 2036 ILE 2037 0.0953

ILE 2037 LEU 2038 0.0036

LEU 2038 ALA 2039 0.0955

ALA 2039 LYS 2040 0.0490

LYS 2040 HIS 2041 0.0758

HIS 2041 VAL 2042 0.0308

VAL 2042 GLY 2043 0.0701

GLY 2043 ALA 2044 0.0942

ALA 2044 GLU 2045 0.0794

GLU 2045 ILE 2046 0.0940

ILE 2046 PHE 2047 0.1084

PHE 2047 ALA 2048 0.0923

ALA 2048 THR 2049 0.1062

THR 2049 VAL 2050 0.0483

VAL 2050 GLY 2051 0.0938

GLY 2051 THR 2052 0.0111

THR 2052 ASP 2053 0.0805

ASP 2053 GLU 2054 0.1114

GLU 2054 LYS 2055 0.0051

LYS 2055 ARG 2056 0.1163

ARG 2056 ASP 2057 0.0561

ASP 2057 LEU 2058 0.0917

LEU 2058 LEU 2059 0.0420

LEU 2059 ILE 2060 0.0856

ILE 2060 LYS 2061 0.0797

LYS 2061 GLU 2062 0.0771

GLU 2062 TYR 2063 0.0265

TYR 2063 LYS 2064 0.1140

LYS 2064 ILE 2065 0.0887

ILE 2065 PRO 2066 0.1106

PRO 2066 ASP 2067 0.0925

ASP 2067 ASP 2068 0.0769

ASP 2068 HIS 2069 0.0594

HIS 2069 ILE 2070 0.1038

ILE 2070 PHE 2071 0.1197

PHE 2071 SER 2072 0.1178

SER 2072 SER 2073 0.0703

SER 2073 ARG 2074 0.1105

ARG 2074 ASN 2075 0.1093

ASN 2075 ALA 2076 0.0429

ALA 2076 LEU 2077 0.0149

LEU 2077 PHE 2078 0.1225

PHE 2078 ALA 2079 0.0115

ALA 2079 LYS 2080 0.1188

LYS 2080 SER 2081 0.0605

SER 2081 ILE 2082 0.0854

ILE 2082 ARG 2083 0.0662

ARG 2083 GLN 2084 0.0716

GLN 2084 ARG 2085 0.1149

ARG 2085 THR 2086 0.0185

THR 2086 ASN 2087 0.1203

ASN 2087 GLY 2088 0.0848

GLY 2088 LYS 2089 0.0932

LYS 2089 GLY 2090 0.1113

GLY 2090 VAL 2091 0.1246

VAL 2091 ASP 2092 0.0637

ASP 2092 VAL 2093 0.1377

VAL 2093 VAL 2094 0.0871

VAL 2094 LEU 2095 0.0950

LEU 2095 ASN 2096 0.1052

ASN 2096 CYS 2097 0.0896

CYS 2097 LEU 2098 0.0999

LEU 2098 ALA 2099 0.0843

ALA 2099 GLY 2100 0.0973

GLY 2100 GLY 2101 0.1048

GLY 2101 LEU 2102 0.0832

LEU 2102 LEU 2103 0.0382

LEU 2103 GLN 2104 0.0810

GLN 2104 GLU 2105 0.0575

GLU 2105 SER 2106 0.1069

SER 2106 PHE 2107 0.0013

PHE 2107 ASP 2108 0.1067

ASP 2108 CYS 2109 0.1073

CYS 2109 LEU 2110 0.0454

LEU 2110 ALA 2111 0.0570

ALA 2111 ASP 2112 0.0008

ASP 2112 PHE 2113 0.0716

PHE 2113 GLY 2114 0.0121

GLY 2114 ARG 2115 0.0741

ARG 2115 PHE 2116 0.0573

PHE 2116 ILE 2117 0.0651

ILE 2117 GLU 2118 0.0690

GLU 2118 ILE 2119 0.0461

ILE 2119 GLY 2120 0.0697

GLY 2120 LYS 2121 0.0681

LYS 2121 ARG 2122 0.0714

ARG 2122 ASP 2123 0.0391

ASP 2123 ILE 2124 0.0424

ILE 2124 GLU 2125 0.1080

GLU 2125 LEU 2126 0.0634

LEU 2126 ASN 2127 0.0113

ASN 2127 HIS 2128 0.0593

HIS 2128 CYS 2129 0.0332

CYS 2129 LEU 2130 0.0632

LEU 2130 ASN 2131 0.0538

ASN 2131 MET 2132 0.0144

MET 2132 GLY 2133 0.0635

GLY 2133 MET 2134 0.0503

MET 2134 PHE 2135 0.0274

PHE 2135 ALA 2136 0.0467

ALA 2136 ARG 2137 0.0433

ARG 2137 SER 2138 0.0577

SER 2138 ALA 2139 0.0114

ALA 2139 THR 2140 0.0626

THR 2140 PHE 2141 -0.1265

PHE 2141 THR 2142 0.0825

THR 2142 ALA 2143 0.0673

ALA 2143 VAL 2144 0.0714

VAL 2144 ASP 2145 0.0810

ASP 2145 LEU 2146 0.0749

LEU 2146 ILE 2147 0.0796

ILE 2147 ALA 2148 0.0072

ALA 2148 ILE 2149 0.0833

ILE 2149 GLY 2150 0.0693

GLY 2150 ARG 2151 0.0460

ARG 2151 ASP 2152 0.0273

ASP 2152 ARG 2153 0.0790

ARG 2153 SER 2154 0.0432

SER 2154 TYR 2155 0.0766

TYR 2155 MET 2156 0.0649

MET 2156 PHE 2157 -0.0989

PHE 2157 ALA 2158 0.0689

ALA 2158 GLU 2159 0.0759

GLU 2159 ALA 2160 0.0267

ALA 2160 LEU 2161 0.0392

LEU 2161 PRO 2162 0.0753

PRO 2162 LYS 2163 0.0762

LYS 2163 ILE 2164 0.0229

ILE 2164 MET 2165 0.0637

MET 2165 THR 2166 0.0697

THR 2166 LEU 2167 0.0655

LEU 2167 LEU 2168 0.0206

LEU 2168 GLN 2169 0.0762

GLN 2169 GLU 2170 0.0738

GLU 2170 LYS 2171 0.0369

LYS 2171 ALA 2172 0.0452

ALA 2172 ILE 2173 0.0681

ILE 2173 ARG 2174 0.0497

ARG 2174 PRO 2175 0.0570

PRO 2175 VAL 2176 0.0630

VAL 2176 THR 2177 0.0214

THR 2177 PRO 2178 0.0564

PRO 2178 ILE 2179 0.0412

ILE 2179 SER 2180 0.0625

SER 2180 ILE 2181 0.0612

ILE 2181 TYR 2182 0.0552

TYR 2182 LYS 2183 0.0568

LYS 2183 ILE 2184 0.0039

ILE 2184 GLY 2185 0.0576

GLY 2185 ASP 2186 0.0525

ASP 2186 ILE 2187 0.0230

ILE 2187 GLU 2188 0.0626

GLU 2188 THR 2189 0.0012

THR 2189 ALA 2190 0.0450

ALA 2190 PHE 2191 0.0212

PHE 2191 ARG 2192 0.0336

ARG 2192 LEU 2193 0.0322

LEU 2193 MET 2194 0.0207

MET 2194 GLN 2195 0.0452

GLN 2195 ALA 2196 0.0118

ALA 2196 GLY 2197 0.0515

GLY 2197 LYS 2198 0.0061

LYS 2198 HIS 2199 0.0506

HIS 2199 MET 2200 0.0503

MET 2200 GLY 2201 0.0395

GLY 2201 LYS 2202 0.0347

LYS 2202 ILE 2203 0.0517

ILE 2203 VAL 2204 0.0491

VAL 2204 ILE 2205 0.0750

ILE 2205 THR 2206 0.0613

THR 2206 ALA 2207 0.0082

ALA 2207 PRO 2208 0.0638

PRO 2208 GLU 2209 0.0199

GLU 2209 ASP 2210 0.0619

ASP 2210 ALA 2211 0.0631

ALA 2211 MET 2212 0.0308

MET 2212 VAL 2213 0.0616

VAL 2213 PRO 2214 0.0375

PRO 2214 VAL 2215 0.0295

VAL 2215 ILE 2216 0.0255

ILE 2216 THR 2217 0.0221

THR 2217 ARG 2218 0.0537

ARG 2218 PRO 2219 0.0013

PRO 2219 PRO 2220 0.0595

PRO 2220 LYS 2221 0.9796

LYS 2221 LEU 2222 0.0136

LEU 2222 GLN 2223 0.0693

GLN 2223 LEU 2224 0.0173

LEU 2224 ARG 2225 0.0695

ARG 2225 PRO 2226 0.0699

PRO 2226 ASP 2227 0.0531

ASP 2227 ALA 2228 0.0313

ALA 2228 SER 2229 0.0283

SER 2229 TYR 2230 0.0684

TYR 2230 LEU 2231 0.0079

LEU 2231 ILE 2232 0.0675

ILE 2232 VAL 2233 0.0094

VAL 2233 GLY 2234 0.0690

GLY 2234 GLY 2235 0.0246

GLY 2235 LEU 2236 0.0634

LEU 2236 GLY 2237 0.0688

GLY 2237 GLY 2238 0.0188

GLY 2238 ILE 2239 0.0429

ILE 2239 GLY 2240 0.0461

GLY 2240 ARG 2241 0.0368

ARG 2241 SER 2242 0.0189

SER 2242 LEU 2243 0.0493

LEU 2243 CYS 2244 0.0491

CYS 2244 LYS 2245 0.0160

LYS 2245 ASN 2246 0.0382

ASN 2246 PHE 2247 0.0453

PHE 2247 VAL 2248 0.0454

VAL 2248 GLU 2249 0.0123

GLU 2249 ASN 2250 0.0492

ASN 2250 GLY 2251 0.0487

GLY 2251 ALA 2252 0.0014

ALA 2252 ARG 2253 0.2072

ARG 2253 SER 2254 0.0052

SER 2254 LEU 2255 0.0461

LEU 2255 VAL 2256 0.0031

VAL 2256 LEU 2257 0.0596

LEU 2257 LEU 2258 0.0125

LEU 2258 SER 2259 0.0493

SER 2259 ARG 2260 0.0011

ARG 2260 ASN 2261 0.0795

ASN 2261 ALA 2262 0.0363

ALA 2262 ASN 2263 0.0688

ASN 2263 VAL 2264 0.0710

VAL 2264 SER 2265 0.0335

SER 2265 GLN 2266 0.0803

GLN 2266 GLN 2267 0.0745

GLN 2267 SER 2268 0.0498

SER 2268 GLY 2269 0.0255

GLY 2269 GLU 2270 0.0217

GLU 2270 PHE 2271 0.0811

PHE 2271 LEU 2272 0.0779

LEU 2272 ASP 2273 0.0450

ASP 2273 GLU 2274 0.0500

GLU 2274 LEU 2275 0.0792

LEU 2275 ARG 2276 0.0809

ARG 2276 SER 2277 0.0221

SER 2277 THR 2278 0.0690

THR 2278 GLY 2279 0.0769

GLY 2279 CYS 2280 0.0356

CYS 2280 ILE 2281 0.0287

ILE 2281 VAL 2282 0.0362

VAL 2282 GLY 2283 0.0134

GLY 2283 VAL 2284 0.0432

VAL 2284 VAL 2285 -0.3507

VAL 2285 ASP 2286 0.0331

ASP 2286 CYS 2287 0.0622

CYS 2287 ASP 2288 0.0600

ASP 2288 ILE 2289 0.0447

ILE 2289 SER 2290 0.0437

SER 2290 SER 2291 0.0281

SER 2291 LYS 2292 0.0614

LYS 2292 THR 2293 0.0402

THR 2293 GLN 2294 0.0454

GLN 2294 VAL 2295 0.0171

VAL 2295 GLU 2296 0.0542

GLU 2296 ALA 2297 0.0545

ALA 2297 THR 2298 0.0159

THR 2298 MET 2299 0.0449

MET 2299 LEU 2300 0.0410

LEU 2300 ARG 2301 -0.0252

ARG 2301 LEU 2302 0.0081

LEU 2302 LYS 2303 0.0448

LYS 2303 LYS 2304 0.0463

LYS 2304 ASP 2305 0.0430

ASP 2305 MET 2306 0.0190

MET 2306 LEU 2307 0.0165

LEU 2307 PRO 2308 0.0472

PRO 2308 ILE 2309 0.0464

ILE 2309 ARG 2310 0.0204

ARG 2310 GLY 2311 0.0467

GLY 2311 ILE 2312 0.0230

ILE 2312 VAL 2313 0.0479

VAL 2313 HIS 2314 0.0098

HIS 2314 ALA 2315 0.0479

ALA 2315 GLY 2316 0.0009

GLY 2316 MET 2317 -0.0961

MET 2317 VAL 2318 0.0355

VAL 2318 LEU 2319 0.0576

LEU 2319 GLN 2320 0.0489

GLN 2320 ASP 2321 0.0449

ASP 2321 SER 2322 0.0592

SER 2322 VAL 2323 0.0343

VAL 2323 PHE 2324 0.0560

PHE 2324 GLU 2325 0.0502

GLU 2325 ARG 2326 0.0137

ARG 2326 MET 2327 0.0590

MET 2327 SER 2328 0.0307

SER 2328 LEU 2329 0.0572

LEU 2329 ASP 2330 0.0379

ASP 2330 ASP 2331 0.0464

ASP 2331 TYR 2332 0.0157

TYR 2332 ASN 2333 -0.2641

ASN 2333 THR 2334 0.0339

THR 2334 ALA 2335 0.0015

ALA 2335 ILE 2336 0.0295

ILE 2336 ARG 2337 0.0237

ARG 2337 PRO 2338 0.0257

PRO 2338 LYS 2339 0.0064

LYS 2339 VAL 2340 0.0320

VAL 2340 GLN 2341 0.0143

GLN 2341 GLY 2342 0.0327

GLY 2342 SER 2343 0.0025

SER 2343 TRP 2344 0.0317

TRP 2344 ASN 2345 0.0171

ASN 2345 LEU 2346 0.0189

LEU 2346 HIS 2347 0.0197

HIS 2347 SER 2348 0.0186

SER 2348 GLY 2349 0.1037

GLY 2349 LEU 2350 0.0014

LEU 2350 SER 2351 0.0281

SER 2351 ASP 2352 0.0292

ASP 2352 CYS 2353 0.0193

CYS 2353 ASP 2354 0.0003

ASP 2354 LEU 2355 0.0290

LEU 2355 ASP 2356 0.0058

ASP 2356 PHE 2357 0.0256

PHE 2357 PHE 2358 0.0100

PHE 2358 ILE 2359 0.0297

ILE 2359 MET 2360 0.0152

MET 2360 LEU 2361 0.0297

LEU 2361 SER 2362 0.0276

SER 2362 SER 2363 0.0295

SER 2363 LEU 2364 0.0205

LEU 2364 ALA 2365 0.2349

ALA 2365 GLY 2366 0.0361

GLY 2366 VAL 2367 0.0011

VAL 2367 SER 2368 0.0368

SER 2368 GLY 2369 0.0154

GLY 2369 SER 2370 0.0192

SER 2370 ALA 2371 0.0302

ALA 2371 SER 2372 0.0022

SER 2372 GLN 2373 0.0364

GLN 2373 ALA 2374 0.0350

ALA 2374 ASN 2375 0.0210

ASN 2375 TYR 2376 0.0337

TYR 2376 THR 2377 0.0026

THR 2377 ALA 2378 0.0360

ALA 2378 GLY 2379 0.0298

GLY 2379 GLY 2380 0.0147

GLY 2380 ALA 2381 0.0659

ALA 2381 TYR 2382 0.0172

TYR 2382 GLN 2383 0.0240

GLN 2383 ASP 2384 0.0027

ASP 2384 ALA 2385 0.0256

ALA 2385 LEU 2386 0.0198

LEU 2386 ALA 2387 0.0106

ALA 2387 LYS 2388 0.0180

LYS 2388 TYR 2389 0.0138

TYR 2389 ARG 2390 0.0266

ARG 2390 ARG 2391 0.0004

ARG 2391 ALA 2392 0.0265

ALA 2392 GLN 2393 0.0157

GLN 2393 GLY 2394 0.0173

GLY 2394 LEU 2395 0.0161

LEU 2395 SER 2396 0.0253

SER 2396 ALA 2397 0.0154

ALA 2397 VAL 2398 0.0325

VAL 2398 SER 2399 0.0180

SER 2399 ILE 2400 0.0326

ILE 2400 ASP 2401 0.0252

ASP 2401 LEU 2402 0.0310

LEU 2402 GLY 2403 0.0325

GLY 2403 MET 2404 0.0223

MET 2404 VAL 2405 0.0318

VAL 2405 GLN 2406 0.0324

GLN 2406 SER 2407 0.0325

SER 2407 VAL 2408 0.0248

VAL 2408 GLY 2409 0.0166

GLY 2409 TYR 2410 0.0180

TYR 2410 VAL 2411 0.0263

VAL 2411 ALA 2412 0.0322

ALA 2412 GLU 2413 0.1596

GLU 2413 THR 2414 0.0180

THR 2414 LYS 2415 0.0222

LYS 2415 GLY 2416 0.0208

GLY 2416 VAL 2417 0.0174

VAL 2417 ALA 2418 0.0033

ALA 2418 GLU 2419 0.0223

GLU 2419 ARG 2420 0.0194

ARG 2420 LEU 2421 0.0099

LEU 2421 VAL 2422 0.0115

VAL 2422 ARG 2423 0.0187

ARG 2423 MET 2424 0.0225

MET 2424 GLY 2425 0.0003

GLY 2425 TYR 2426 0.0226

TYR 2426 SER 2427 0.0124

SER 2427 PRO 2428 0.0211

PRO 2428 ILE 2429 0.2272

ILE 2429 SER 2430 0.0339

SER 2430 GLU 2431 0.0339

GLU 2431 MET 2432 0.0059

MET 2432 GLU 2433 0.0375

GLU 2433 VAL 2434 0.0077

VAL 2434 LEU 2435 0.0330

LEU 2435 LYS 2436 0.0127

LYS 2436 ILE 2437 0.0258

ILE 2437 VAL 2438 0.0255

VAL 2438 GLU 2439 0.0131

GLU 2439 HIS 2440 0.0319

HIS 2440 ALA 2441 0.0099

ALA 2441 ILE 2442 0.0371

ILE 2442 THR 2443 0.0019

THR 2443 ASN 2444 0.0371

ASN 2444 PRO 2445 -0.1541

PRO 2445 PRO 2446 0.0128

PRO 2446 PRO 2447 0.0134

PRO 2447 GLU 2448 0.0145

GLU 2448 ALA 2449 0.0035

ALA 2449 SER 2450 0.0126

SER 2450 SER 2451 0.0147

SER 2451 ALA 2452 0.0019

ALA 2452 GLN 2453 0.0150

GLN 2453 ILE 2454 0.0132

ILE 2454 ILE 2455 0.0152

ILE 2455 THR 2456 0.0152

THR 2456 GLY 2457 0.0154

GLY 2457 ILE 2458 0.0104

ILE 2458 SER 2459 0.0095

SER 2459 THR 2460 0.0012

THR 2460 LYS 2461 0.1700

LYS 2461 PRO 2462 0.0089

PRO 2462 GLY 2463 0.0025

GLY 2463 ARG 2464 0.0049

ARG 2464 HIS 2465 0.0073

HIS 2465 TRP 2466 0.0048

TRP 2466 THR 2467 0.0084

THR 2467 GLU 2468 0.0007

GLU 2468 SER 2469 0.0088

SER 2469 SER 2470 0.0085

SER 2470 TRP 2471 0.0090

TRP 2471 LEU 2472 0.0011

LEU 2472 GLN 2473 0.0090

GLN 2473 ASP 2474 0.0089

ASP 2474 ALA 2475 0.0030

ALA 2475 ARG 2476 0.0092

ARG 2476 PHE 2477 0.1370

PHE 2477 ALA 2478 0.0026

ALA 2478 THR 2479 0.0043

THR 2479 LEU 2480 0.0011

LEU 2480 ARG 2481 0.0049

ARG 2481 GLU 2482 0.0014

GLU 2482 ARG 2483 0.0048

ARG 2483 ALA 2484 0.0014

ALA 2484 ARG 2485 0.0037

ARG 2485 ASP 2486 0.0032

ASP 2486 VAL 2487 0.0018

VAL 2487 LYS 2488 0.0050

LYS 2488 GLU 2489 0.0012

GLU 2489 LEU 2490 0.0052

LEU 2490 SER 2491 0.0015

SER 2491 ASN 2492 0.0045

ASN 2492 SER 2493 0.0215

SER 2493 GLN 2494 0.0191

GLN 2494 ASN 989 0.1407

ASN 989 LYS 990 0.0946

LYS 990 ALA 991 0.1153

ALA 991 HIS 992 0.1100

HIS 992 ARG 993 0.0316

ARG 993 GLN 994 0.1174

GLN 994 ARG 995 0.1149

ARG 995 VAL 996 0.0807

VAL 996 HIS 997 0.1185

HIS 997 PRO 998 0.1153

PRO 998 PRO 999 0.0726

PRO 999 HIS 1000 0.1176

HIS 1000 ASP 1001 0.1184

ASP 1001 LEU 1002 0.0593

LEU 1002 LEU 1003 0.0887

LEU 1003 GLY 1004 0.1178

GLY 1004 SER 1005 0.0619

SER 1005 LEU 1006 0.0523

LEU 1006 ILE 1007 0.0070

ILE 1007 VAL 1008 0.0618

VAL 1008 GLY 1009 0.0293

GLY 1009 ARG 1010 0.0619

ARG 1010 ASP 1011 0.0605

ASP 1011 LEU 1012 0.0056

LEU 1012 ARG 1013 0.0556

ARG 1013 GLU 1014 0.0524

GLU 1014 PRO 1015 0.0407

PRO 1015 THR 1016 0.0603

THR 1016 TRP 1017 0.0376

TRP 1017 ARG 1018 0.0568

ARG 1018 HIS 1019 0.0430

HIS 1019 PHE 1020 0.0608

PHE 1020 ILE 1021 0.1513

ILE 1021 ARG 1022 0.0324

ARG 1022 VAL 1023 0.0624

VAL 1023 GLN 1024 0.0125

GLN 1024 ASP 1025 0.0726

ASP 1025 ILE 1026 0.0595

ILE 1026 PRO 1027 0.0643

PRO 1027 TRP 1028 0.0611

TRP 1028 ILE 1029 0.0197

ILE 1029 ARG 1030 0.0652

ARG 1030 ASP 1031 0.0734

ASP 1031 HIS 1032 0.0019

HIS 1032 VAL 1033 0.0600

VAL 1033 VAL 1034 0.0062

VAL 1034 GLN 1035 0.0668

GLN 1035 SER 1036 0.0204

SER 1036 ALA 1037 0.2487

ALA 1037 LEU 1038 0.0356

LEU 1038 VAL 1039 0.0495

VAL 1039 TYR 1040 0.0552

TYR 1040 PRO 1041 0.0606

PRO 1041 GLY 1042 0.0302

GLY 1042 ALA 1043 0.0278

ALA 1043 GLY 1044 0.0575

GLY 1044 PHE 1045 0.0179

PHE 1045 ILE 1046 0.0585

ILE 1046 CYS 1047 0.0083

CYS 1047 MET 1048 0.0532

MET 1048 ALA 1049 0.0425

ALA 1049 MET 1050 0.0245

MET 1050 GLU 1051 0.0428

GLU 1051 ALA 1052 0.0270

ALA 1052 MET 1053 0.0500

MET 1053 VAL 1054 0.0121

VAL 1054 GLN 1055 0.0631

GLN 1055 LEU 1056 0.0414

LEU 1056 HIS 1057 0.0335

HIS 1057 GLU 1058 0.0496

GLU 1058 LEU 1059 0.0307

LEU 1059 ARG 1060 0.0681

ARG 1060 ASP 1061 0.0230

ASP 1061 SER 1062 0.0380

SER 1062 GLN 1063 0.0611

GLN 1063 SER 1064 0.0472

SER 1064 ARG 1065 0.0631

ARG 1065 LYS 1066 0.0549

LYS 1066 VAL 1067 0.0456

VAL 1067 ALA 1068 0.0696

ALA 1068 GLY 1069 0.0216

GLY 1069 TYR 1070 0.0182

TYR 1070 ARG 1071 0.0146

ARG 1071 LEU 1072 0.0265

LEU 1072 ALA 1073 0.0110

ALA 1073 GLU 1074 0.0199

GLU 1074 VAL 1075 0.0391

VAL 1075 ASP 1076 0.0334

ASP 1076 ILE 1077 0.0458

ILE 1077 LEU 1078 0.0147

LEU 1078 ARG 1079 0.0463

ARG 1079 ALA 1080 0.0154

ALA 1080 MET 1081 0.0430

MET 1081 LEU 1082 0.0494

LEU 1082 ILE 1083 0.0192

ILE 1083 PRO 1084 0.0516

PRO 1084 ASP 1085 -0.1860

ASP 1085 THR 1086 0.0554

THR 1086 SER 1087 0.0479

SER 1087 GLU 1088 0.0259

GLU 1088 GLY 1089 0.0580

GLY 1089 LEU 1090 0.0332

LEU 1090 GLU 1091 0.0536

GLU 1091 ALA 1092 0.0578

ALA 1092 HIS 1093 0.0546

HIS 1093 ILE 1094 0.0559

ILE 1094 SER 1095 0.0421

SER 1095 LEU 1096 0.0564

LEU 1096 ARG 1097 0.0274

ARG 1097 PRO 1098 0.0575

PRO 1098 CYS 1099 0.0449

CYS 1099 SER 1100 0.0256

SER 1100 THR 1101 0.0222

THR 1101 LYS 1102 0.0199

LYS 1102 LEU 1103 0.0204

LEU 1103 LEU 1104 0.0418

LEU 1104 LEU 1105 0.0014

LEU 1105 THR 1106 0.0356

THR 1106 ASN 1107 0.0205

ASN 1107 GLU 1108 0.0421

GLU 1108 TRP 1109 0.0420

TRP 1109 TYR 1110 0.0419

TYR 1110 ASP 1111 0.0377

ASP 1111 PHE 1112 0.0193

PHE 1112 CYS 1113 0.0417

CYS 1113 VAL 1114 0.0184

VAL 1114 SER 1115 0.0392

SER 1115 SER 1116 0.0352

SER 1116 VAL 1117 0.0033

VAL 1117 GLY 1118 0.0361

GLY 1118 ASP 1119 0.0359

ASP 1119 ASP 1120 0.0037

ASP 1120 ASP 1121 0.0365

ASP 1121 LYS 1122 0.0368

LYS 1122 PHE 1123 0.0257

PHE 1123 VAL 1124 0.0332

VAL 1124 ASP 1125 0.0340

ASP 1125 HIS 1126 0.0106

HIS 1126 CYS 1127 0.0355

CYS 1127 ARG 1128 0.0326

ARG 1128 GLY 1129 0.0338

GLY 1129 ARG 1130 0.0363

ARG 1130 ILE 1131 0.0128

ILE 1131 THR 1132 0.0334

THR 1132 ILE 1133 0.0210

ILE 1133 GLU 1134 0.0563

GLU 1134 PHE 1135 0.0460

PHE 1135 ASP 1136 0.0302

ASP 1136 THR 1137 0.0581

THR 1137 SER 1138 0.0363

SER 1138 GLY 1139 0.0631

GLY 1139 SER 1140 0.0621

SER 1140 ALA 1141 0.0337

ALA 1141 ASP 1142 0.0683

ASP 1142 THR 1143 0.0268

THR 1143 PRO 1144 0.0390

PRO 1144 ARG 1145 0.0631

ARG 1145 THR 1146 0.0676

THR 1146 SER 1147 0.0197

SER 1147 LEU 1148 0.0667

LEU 1148 ARG 1149 0.4948

ARG 1149 GLU 1150 0.0130

GLU 1150 ARG 1151 0.0594

ARG 1151 SER 1152 0.0431

SER 1152 ARG 1153 0.0300

ARG 1153 SER 1154 0.0667

SER 1154 THR 1155 0.0660

THR 1155 GLY 1156 0.0206

GLY 1156 LEU 1157 0.0131

LEU 1157 MET 1158 0.0300

MET 1158 ARG 1159 0.0145

ARG 1159 SER 1160 0.0226

SER 1160 VAL 1161 0.0384

VAL 1161 ASP 1162 0.0077

ASP 1162 PRO 1163 0.0656

PRO 1163 SER 1164 0.0137

SER 1164 ASN 1165 0.0617

ASN 1165 LEU 1166 0.0225

LEU 1166 TYR 1167 0.0216

TYR 1167 SER 1168 0.0351

SER 1168 PHE 1169 0.0053

PHE 1169 LEU 1170 0.0382

LEU 1170 ARG 1171 0.0117

ARG 1171 ALA 1172 0.0375

ALA 1172 GLN 1173 0.0104

GLN 1173 GLY 1174 0.0299

GLY 1174 ILE 1175 0.0402

ILE 1175 TYR 1176 0.0049

TYR 1176 HIS 1177 0.0398

HIS 1177 GLY 1178 0.0020

GLY 1178 PRO 1179 0.0319

PRO 1179 ILE 1180 0.0356

ILE 1180 PHE 1181 -0.0036

PHE 1181 GLN 1182 0.0514

GLN 1182 ASN 1183 0.0492

ASN 1183 LEU 1184 0.0309

LEU 1184 LYS 1185 0.0468

LYS 1185 THR 1186 0.0217

THR 1186 ILE 1187 0.0130

ILE 1187 SER 1188 0.0236

SER 1188 SER 1189 0.0205

SER 1189 ARG 1190 0.0091

ARG 1190 LYS 1191 0.0266

LYS 1191 ASP 1192 0.0473

ASP 1192 HIS 1193 0.0281

HIS 1193 SER 1194 0.0027

SER 1194 GLU 1195 0.0303

GLU 1195 SER 1196 0.0125

SER 1196 SER 1197 0.0971

SER 1197 PHE 1198 0.0527

PHE 1198 VAL 1199 0.0301

VAL 1199 VAL 1200 0.0649

VAL 1200 ALA 1201 0.0502

ALA 1201 ASN 1202 0.0249

ASN 1202 THR 1203 0.0517

THR 1203 ALA 1204 0.0380

ALA 1204 SER 1205 0.0337

SER 1205 VAL 1206 0.0547

VAL 1206 MET 1207 0.0625

MET 1207 PRO 1208 0.0402

PRO 1208 ASN 1209 0.0316

ASN 1209 GLY 1210 0.0533

GLY 1210 PHE 1211 0.0412

PHE 1211 GLN 1212 0.0061

GLN 1212 SER 1213 -0.0011

SER 1213 PRO 1214 0.0565

PRO 1214 HIS 1215 0.0176

HIS 1215 VAL 1216 0.0378

VAL 1216 ILE 1217 0.0600

ILE 1217 HIS 1218 0.0510

HIS 1218 PRO 1219 0.0400

PRO 1219 THR 1220 0.0397

THR 1220 THR 1221 0.0592

THR 1221 LEU 1222 0.0010

LEU 1222 ASP 1223 0.0597

ASP 1223 SER 1224 0.0443

SER 1224 ILE 1225 0.0282

ILE 1225 PHE 1226 0.0345

PHE 1226 GLN 1227 0.0430

GLN 1227 GLY 1228 0.0597

GLY 1228 ALA 1229 -0.1057

ALA 1229 TYR 1230 0.0475

TYR 1230 THR 1231 0.0452

THR 1231 ALA 1232 0.0082

ALA 1232 LEU 1233 0.0394

LEU 1233 PRO 1234 0.0442

PRO 1234 GLY 1235 0.0160

GLY 1235 ALA 1236 0.0349

ALA 1236 GLY 1237 0.0457

GLY 1237 LEU 1238 0.0412

LEU 1238 ASP 1239 0.0095

ASP 1239 GLN 1240 0.0466

GLN 1240 ASN 1241 0.0434

ASN 1241 THR 1242 0.0426

THR 1242 ALA 1243 0.0253

ALA 1243 MET 1244 0.0416

MET 1244 ILE 1245 0.2698

ILE 1245 PRO 1246 0.0553

PRO 1246 ARG 1247 0.0174

ARG 1247 SER 1248 0.0551

SER 1248 ILE 1249 0.0463

ILE 1249 GLN 1250 0.0403

GLN 1250 GLU 1251 0.0212

GLU 1251 LEU 1252 0.0015

LEU 1252 TYR 1253 0.0299

TYR 1253 LEU 1254 0.0019

LEU 1254 SER 1255 0.0327

SER 1255 SER 1256 0.0217

SER 1256 ALA 1257 0.0417

ALA 1257 LEU 1258 0.0551

LEU 1258 THR 1259 0.0109

THR 1259 SER 1260 0.0548

SER 1260 ASP 1261 0.1101

ASP 1261 VAL 1262 0.0583

VAL 1262 GLY 1263 0.0554

GLY 1263 GLN 1264 0.0387

GLN 1264 CYS 1265 0.0248

CYS 1265 LEU 1266 0.0110

LEU 1266 VAL 1267 0.0180

VAL 1267 SER 1268 0.0164

SER 1268 ASP 1269 0.0111

ASP 1269 THR 1270 0.0349

THR 1270 SER 1271 0.0005

SER 1271 LEU 1272 0.0392

LEU 1272 ILE 1273 0.0276

ILE 1273 ARG 1274 0.0525

ARG 1274 TYR 1275 0.0589

TYR 1275 ASP 1276 0.0436

ASP 1276 GLY 1277 -0.0284

GLY 1277 GLN 1278 0.0551

GLN 1278 SER 1279 0.0554

SER 1279 PHE 1280 0.0561

PHE 1280 THR 1281 0.0583

THR 1281 VAL 1282 0.0400

VAL 1282 ASN 1283 0.0516

ASN 1283 VAL 1284 0.0040

VAL 1284 ASP 1285 0.0459

ASP 1285 VAL 1286 0.0014

VAL 1286 SER 1287 0.0390

SER 1287 SER 1288 0.0052

SER 1288 LYS 1289 0.0588

LYS 1289 ALA 1290 0.0338

ALA 1290 ASP 1291 0.0344

ASP 1291 SER 1292 0.0484

SER 1292 GLU 1293 0.0305

GLU 1293 HIS 1294 0.0584

HIS 1294 THR 1295 0.0638

THR 1295 PRO 1296 0.0549

PRO 1296 VAL 1297 0.0417

VAL 1297 LEU 1298 0.0338

LEU 1298 GLU 1299 0.0012

GLU 1299 ILE 1300 0.0363

ILE 1300 LYS 1301 0.0032

LYS 1301 GLY 1302 0.0360

GLY 1302 LEU 1303 0.0436

LEU 1303 ARG 1304 0.0361

ARG 1304 ASN 1305 0.0615

ASN 1305 GLN 1306 0.0422

GLN 1306 SER 1307 0.0652

SER 1307 VAL 1308 0.0580

VAL 1308 GLY 1309 0.3042

GLY 1309 GLN 1310 0.0385

GLN 1310 MET 1311 0.0343

MET 1311 ALA 1312 0.0339

ALA 1312 PRO 1313 0.0233

PRO 1313 GLN 1314 0.0350

GLN 1314 PRO 1315 0.0372

PRO 1315 GLY 1316 0.0191

GLY 1316 ASP 1317 0.0401

ASP 1317 SER 1318 0.0187

SER 1318 SER 1319 0.0326

SER 1319 ASN 1320 0.0393

ASN 1320 ASN 1321 0.0143

ASN 1321 ASP 1322 0.0367

ASP 1322 LEU 1323 0.0242

LEU 1323 CYS 1324 0.0397

CYS 1324 PHE 1325 0.0191

PHE 1325 LYS 1326 0.0005

LYS 1326 LEU 1327 0.0076

LEU 1327 ASP 1328 0.0083

ASP 1328 TRP 1329 0.0046

TRP 1329 ALA 1330 0.0104

ALA 1330 PRO 1331 0.0068

PRO 1331 ASP 1332 0.0096

ASP 1332 ILE 1333 0.0116

ILE 1333 SER 1334 0.0112

SER 1334 SER 1335 0.0025

SER 1335 VAL 1336 0.0094

VAL 1336 LYS 1337 0.0024

LYS 1337 GLN 1338 0.0112

GLN 1338 GLU 1339 0.0028

GLU 1339 ARG 1340 0.0090

ARG 1340 LEU 1341 0.2583

LEU 1341 LYS 1342 0.0080

LYS 1342 GLU 1343 0.0081

GLU 1343 LYS 1344 0.0051

LYS 1344 PHE 1345 0.0111

PHE 1345 GLY 1346 0.0047

GLY 1346 PHE 1347 0.0137

PHE 1347 PRO 1348 0.0117

PRO 1348 LEU 1349 0.0080

LEU 1349 ASP 1350 0.0106

ASP 1350 PRO 1351 0.0094

PRO 1351 THR 1352 0.0126

THR 1352 GLU 1353 0.0118

GLU 1353 ALA 1354 0.0033

ALA 1354 ASP 1355 0.0134

ASP 1355 ILE 1356 0.0129

ILE 1356 ILE 1357 -0.0790

ILE 1357 MET 1358 0.0234

MET 1358 GLY 1359 0.0409

GLY 1359 LEU 1360 0.0403

LEU 1360 ARG 1361 0.0186

ARG 1361 GLN 1362 0.0336

GLN 1362 ALA 1363 0.0404

ALA 1363 CYS 1364 0.0342

CYS 1364 ILE 1365 0.0153

ILE 1365 HIS 1366 0.0403

HIS 1366 PHE 1367 0.0407

PHE 1367 ILE 1368 0.0261

ILE 1368 HIS 1369 0.0244

HIS 1369 ARG 1370 0.0407

ARG 1370 SER 1371 0.0405

SER 1371 LEU 1372 0.0198

LEU 1372 GLN 1373 0.0278

GLN 1373 SER 1374 0.0458

SER 1374 LEU 1375 0.0464

LEU 1375 THR 1376 0.0089

THR 1376 ALA 1377 0.0347

ALA 1377 PRO 1378 0.0446

PRO 1378 ASP 1379 0.0035

ASP 1379 ARG 1380 0.0470

ARG 1380 ASP 1381 0.0395

ASP 1381 GLN 1382 0.0215

GLN 1382 LEU 1383 0.0232

LEU 1383 ASP 1384 0.0305

ASP 1384 TRP 1385 0.0472

TRP 1385 HIS 1386 0.0158

HIS 1386 GLN 1387 0.0408

GLN 1387 LYS 1388 0.0180

LYS 1388 ARG 1389 0.0470

ARG 1389 PHE 1390 0.0353

PHE 1390 TYR 1391 0.0133

TYR 1391 ASP 1392 0.0450

ASP 1392 TRP 1393 0.0097

TRP 1393 MET 1394 0.0487

MET 1394 VAL 1395 0.0099

VAL 1395 LEU 1396 0.0422

LEU 1396 GLN 1397 0.0221

GLN 1397 ILE 1398 0.0290

ILE 1398 GLN 1399 0.0361

GLN 1399 LEU 1400 0.0147

LEU 1400 ALA 1401 0.0463

ALA 1401 GLU 1402 0.0095

GLU 1402 GLU 1403 0.0484

GLU 1403 ASP 1404 0.0113

ASP 1404 ARG 1405 0.0141

ARG 1405 LEU 1406 0.0289

LEU 1406 ALA 1407 0.0480

ALA 1407 PRO 1408 0.0509

PRO 1408 ASN 1409 0.0376

ASN 1409 SER 1410 0.0563

SER 1410 SER 1411 0.0056

SER 1411 ALA 1412 0.0495

ALA 1412 TRP 1413 0.0411

TRP 1413 LEU 1414 0.0159

LEU 1414 GLN 1415 0.0546

GLN 1415 CYS 1416 0.0160

CYS 1416 SER 1417 0.0564

SER 1417 SER 1418 0.0505

SER 1418 SER 1419 0.0234

SER 1419 ASP 1420 0.0527

ASP 1420 GLU 1421 0.0767

GLU 1421 GLN 1422 0.0284

GLN 1422 LYS 1423 0.0253

LYS 1423 LEU 1424 0.0470

LEU 1424 LEU 1425 0.0480

LEU 1425 GLU 1426 0.0146

GLU 1426 ASN 1427 0.0414

ASN 1427 VAL 1428 0.0444

VAL 1428 ARG 1429 0.0417

ARG 1429 ALA 1430 0.0122

ALA 1430 SER 1431 0.0479

SER 1431 SER 1432 0.0483

SER 1432 VAL 1433 0.0479

VAL 1433 ASN 1434 0.0128

ASN 1434 GLY 1435 0.0435

GLY 1435 GLN 1436 0.0436

GLN 1436 MET 1437 0.0084

MET 1437 VAL 1438 0.0133

VAL 1438 VAL 1439 0.0428

VAL 1439 HIS 1440 0.0416

HIS 1440 VAL 1441 0.0271

VAL 1441 GLY 1442 0.0232

GLY 1442 LYS 1443 0.0430

LYS 1443 SER 1444 0.0424

SER 1444 MET 1445 0.0314

MET 1445 LEU 1446 0.0103

LEU 1446 ALA 1447 0.0368

ALA 1447 ILE 1448 0.0379

ILE 1448 LEU 1449 0.0092

LEU 1449 ARG 1450 0.0374

ARG 1450 HIS 1451 0.0234

HIS 1451 GLU 1452 0.0374

GLU 1452 ILE 1453 0.0335

ILE 1453 ALA 1454 0.0272

ALA 1454 PRO 1455 0.0312

PRO 1455 LEU 1456 0.0092

LEU 1456 GLU 1457 0.0225

GLU 1457 LEU 1458 0.0269

LEU 1458 MET 1459 0.0288

MET 1459 LEU 1460 0.0048

LEU 1460 GLN 1461 0.0308

GLN 1461 ASP 1462 0.0166

ASP 1462 LYS 1463 0.0309

LYS 1463 LEU 1464 0.0108

LEU 1464 LEU 1465 0.0296

LEU 1465 TYR 1466 0.0054

TYR 1466 ARG 1467 0.0310

ARG 1467 TYR 1468 0.0052

TYR 1468 TYR 1469 0.0719

TYR 1469 THR 1470 0.0044

THR 1470 ASP 1471 0.0119

ASP 1471 ALA 1472 0.0010

ALA 1472 ILE 1473 0.0120

ILE 1473 LYS 1474 0.0127

LYS 1474 TRP 1475 0.0087

TRP 1475 ASP 1476 0.0027

ASP 1476 ARG 1477 0.0120

ARG 1477 SER 1478 0.0119

SER 1478 TYR 1479 0.0037

TYR 1479 GLN 1480 0.0091

GLN 1480 GLN 1481 0.0100

GLN 1481 ILE 1482 0.0123

ILE 1482 ASP 1483 0.0011

ASP 1483 GLN 1484 0.0126

GLN 1484 LEU 1485 0.1079

LEU 1485 VAL 1486 0.0014

VAL 1486 LYS 1487 0.0007

LYS 1487 LEU 1488 0.0018

LEU 1488 HIS 1489 0.0020

HIS 1489 ALA 1490 0.0011

ALA 1490 HIS 1491 0.0010

HIS 1491 LYS 1492 0.0016

LYS 1492 CYS 1493 0.0016

CYS 1493 PRO 1494 0.0014

PRO 1494 THR 1495 0.0018

THR 1495 ALA 1496 0.0001

ALA 1496 LYS 1497 0.0014

LYS 1497 ILE 1498 0.0005

ILE 1498 ILE 1499 0.0006

ILE 1499 GLU 1500 0.0006

GLU 1500 ILE 1501 0.0167

ILE 1501 GLY 1502 0.0055

GLY 1502 ALA 1503 0.0025

ALA 1503 GLY 1504 0.0051

GLY 1504 THR 1505 0.0052

THR 1505 GLY 1506 0.0026

GLY 1506 GLY 1507 0.0070

GLY 1507 CYS 1508 0.0064

CYS 1508 THR 1509 0.0045

THR 1509 ARG 1510 0.0044

ARG 1510 ALA 1511 0.0068

ALA 1511 VAL 1512 0.0068

VAL 1512 LEU 1513 0.0040

LEU 1513 ASP 1514 0.0054

ASP 1514 ALA 1515 0.0070

ALA 1515 LEU 1516 0.0065

LEU 1516 SER 1517 0.0616

SER 1517 ASN 1518 0.0009

ASN 1518 GLN 1519 0.0029

GLN 1519 GLY 1520 0.0025

GLY 1520 ILE 1521 0.0026

ILE 1521 ALA 1522 0.0019

ALA 1522 ARG 1523 0.0028

ARG 1523 CYS 1524 0.0021

CYS 1524 ALA 1525 0.0028

ALA 1525 GLN 1526 0.0002

GLN 1526 TYR 1527 0.0009

TYR 1527 ASP 1528 0.0008

ASP 1528 PHE 1529 0.0013

PHE 1529 THR 1530 0.0010

THR 1530 ASP 1531 0.0002

ASP 1531 VAL 1532 0.0007

VAL 1532 SER 1533 -0.0135

SER 1533 SER 1534 0.0012

SER 1534 GLY 1535 0.0055

GLY 1535 PHE 1536 0.0036

PHE 1536 PHE 1537 0.0023

PHE 1537 GLU 1538 0.0043

GLU 1538 ALA 1539 0.0056

ALA 1539 ALA 1540 0.0053

ALA 1540 GLN 1541 0.0025

GLN 1541 GLN 1542 0.0050

GLN 1542 LYS 1543 0.0054

LYS 1543 PHE 1544 0.0044

PHE 1544 ALA 1545 0.0027

ALA 1545 ALA 1546 0.0034

ALA 1546 PHE 1547 0.0049

PHE 1547 ASP 1548 0.0054

ASP 1548 ASP 1549 -0.0015

ASP 1549 VAL 1550 0.0042

VAL 1550 ILE 1551 0.0003

ILE 1551 ARG 1552 0.0031

ARG 1552 PHE 1553 0.0007

PHE 1553 GLN 1554 0.0024

GLN 1554 LYS 1555 0.0003

LYS 1555 LEU 1556 0.0048

LEU 1556 ASP 1557 0.0010

ASP 1557 ILE 1558 0.0049

ILE 1558 GLU 1559 0.0010

GLU 1559 LYS 1560 0.0047

LYS 1560 ASP 1561 0.0031

ASP 1561 ILE 1562 0.0004

ILE 1562 GLU 1563 0.0043

GLU 1563 MET 1564 0.0021

MET 1564 GLN 1565 -0.0210

GLN 1565 GLY 1566 0.0006

GLY 1566 PHE 1567 0.0058

PHE 1567 GLU 1568 0.0054

GLU 1568 CYS 1569 0.0033

CYS 1569 GLY 1570 0.0057

GLY 1570 SER 1571 0.0021

SER 1571 TYR 1572 0.0058

TYR 1572 ASP 1573 0.0057

ASP 1573 LEU 1574 0.0042

LEU 1574 VAL 1575 0.0025

VAL 1575 ILE 1576 0.0054

ILE 1576 ALA 1577 0.0013

ALA 1577 SER 1578 0.0055

SER 1578 GLN 1579 0.0012

GLN 1579 VAL 1580 0.0058

VAL 1580 LEU 1581 0.0579

LEU 1581 HIS 1582 0.0000

HIS 1582 ALA 1583 0.0057

ALA 1583 THR 1584 0.0051

THR 1584 GLY 1585 0.0045

GLY 1585 LYS 1586 0.0053

LYS 1586 MET 1587 0.0051

MET 1587 GLU 1588 0.0045

GLU 1588 HIS 1589 0.0038

HIS 1589 THR 1590 0.0056

THR 1590 MET 1591 0.0055

MET 1591 ALA 1592 0.0040

ALA 1592 ASN 1593 0.0042

ASN 1593 VAL 1594 0.0056

VAL 1594 ARG 1595 0.0049

ARG 1595 LYS 1596 0.0026

LYS 1596 LEU 1597 0.0712

LEU 1597 LEU 1598 0.0039

LEU 1598 LYS 1599 0.0032

LYS 1599 PRO 1600 0.0027

PRO 1600 GLY 1601 0.0039

GLY 1601 GLY 1602 0.0036

GLY 1602 LYS 1603 0.0034

LYS 1603 LEU 1604 0.0025

LEU 1604 LEU 1605 0.0038

LEU 1605 LEU 1606 0.0017

LEU 1606 VAL 1607 0.0039

VAL 1607 GLU 1608 0.0005

GLU 1608 THR 1609 0.0018

THR 1609 THR 1610 0.0024

THR 1610 ARG 1611 0.0027

ARG 1611 ASP 1612 0.0035

ASP 1612 GLU 1613 0.1023

GLU 1613 MET 1614 0.0130

MET 1614 ASP 1615 0.0182

ASP 1615 LEU 1616 0.0231

LEU 1616 GLN 1617 0.0056

GLN 1617 LEU 1618 0.0235

LEU 1618 VAL 1619 0.0121

VAL 1619 PHE 1620 0.0273

PHE 1620 GLY 1621 0.0031

GLY 1621 LEU 1622 0.0261

LEU 1622 LEU 1623 0.0188

LEU 1623 PRO 1624 0.0238

PRO 1624 GLY 1625 0.0089

GLY 1625 TRP 1626 0.0262

TRP 1626 TRP 1627 0.0087

TRP 1627 LEU 1628 0.0248

LEU 1628 SER 1629 -0.1070

SER 1629 SER 1630 0.0119

SER 1630 GLU 1631 0.0142

GLU 1631 GLU 1632 0.0032

GLU 1632 GLU 1633 0.0126

GLU 1633 ARG 1634 0.0125

ARG 1634 GLN 1635 0.0056

GLN 1635 MET 1636 0.0127

MET 1636 SER 1637 0.0025

SER 1637 PRO 1638 0.0026

PRO 1638 SER 1639 0.0121

SER 1639 LEU 1640 0.0134

LEU 1640 SER 1641 0.0142

SER 1641 THR 1642 0.0036

THR 1642 ASN 1643 0.0127

ASN 1643 SER 1644 0.0139

SER 1644 TRP 1645 0.0172

TRP 1645 GLU 1646 0.0038

GLU 1646 LYS 1647 0.0040

LYS 1647 VAL 1648 0.0041

VAL 1648 LEU 1649 0.0009

LEU 1649 LYS 1650 0.0044

LYS 1650 LYS 1651 0.0043

LYS 1651 THR 1652 0.0028

THR 1652 GLY 1653 0.0012

GLY 1653 PHE 1654 0.0044

PHE 1654 ASP 1655 0.0045

ASP 1655 GLY 1656 0.0013

GLY 1656 LEU 1657 0.0043

LEU 1657 ASP 1658 0.0021

ASP 1658 ILE 1659 0.0037

ILE 1659 GLU 1660 0.0006

GLU 1660 LEU 1661 0.0500

LEU 1661 ARG 1662 0.0083

ARG 1662 ASP 1663 0.0101

ASP 1663 CYS 1664 0.0109

CYS 1664 ASP 1665 0.0101

ASP 1665 SER 1666 0.0027

SER 1666 ASP 1667 0.0030

ASP 1667 GLU 1668 0.0103

GLU 1668 PHE 1669 0.0051

PHE 1669 TYR 1670 0.0093

TYR 1670 SER 1671 0.0114

SER 1671 PHE 1672 0.0053

PHE 1672 SER 1673 0.0107

SER 1673 VAL 1674 0.0029

VAL 1674 MET 1675 0.0104

MET 1675 MET 1676 0.0082

MET 1676 ALA 1677 0.1955

ALA 1677 THR 1678 0.0651

THR 1678 ALA 1679 0.0691

ALA 1679 SER 1680 0.0716

SER 1680 SER 1681 0.0457

SER 1681 THR 1682 0.0743

THR 1682 ILE 1683 0.0419

ILE 1683 ALA 1684 0.0742

ALA 1684 SER 1685 0.0766

SER 1685 SER 1686 0.0113

SER 1686 SER 1687 0.0751

SER 1687 MET 1688 0.0155

MET 1688 ALA 1689 0.0629

ALA 1689 PHE 1690 0.0656

PHE 1690 ALA 1691 0.0395

ALA 1691 ILE 1692 0.0719

ILE 1692 VAL 1693 -0.1925

VAL 1693 TYR 1694 0.0504

TYR 1694 GLY 1695 0.0161

GLY 1695 GLU 1696 0.0396

GLU 1696 VAL 1697 0.0197

VAL 1697 PRO 1698 0.0285

PRO 1698 LEU 1699 0.0064

LEU 1699 PRO 1700 0.0297

PRO 1700 ASP 1701 0.0459

ASP 1701 GLN 1702 0.0069

GLN 1702 PHE 1703 0.0513

PHE 1703 LEU 1704 0.0429

LEU 1704 ASP 1705 0.0224

ASP 1705 ASP 1706 0.0311

ASP 1706 MET 1707 0.0360

MET 1707 LYS 1708 0.0532

LYS 1708 THR 1709 0.0214

THR 1709 ALA 1710 0.0518

ALA 1710 ILE 1711 0.0336

ILE 1711 SER 1712 0.0423

SER 1712 SER 1713 0.0117

SER 1713 SER 1714 0.0456

SER 1714 ALA 1715 0.0352

ALA 1715 VAL 1716 0.0518

VAL 1716 SER 1717 0.0209

SER 1717 ASP 1718 0.0491

ASP 1718 PRO 1719 0.0176

PRO 1719 VAL 1720 0.0140

VAL 1720 VAL 1721 0.0455

VAL 1721 GLY 1722 0.0013

GLY 1722 HIS 1723 0.0198

HIS 1723 LEU 1724 0.0390

LEU 1724 ASP 1725 -0.0111

ASP 1725 SER 1726 0.0399

SER 1726 ILE 1727 0.0194

ILE 1727 ASP 1728 0.0513

ASP 1728 ALA 1729 0.0430

ALA 1729 THR 1730 0.0508

THR 1730 GLY 1731 0.0169

GLY 1731 LYS 1732 0.0382

LYS 1732 PHE 1733 0.0430

PHE 1733 CYS 1734 0.0416

CYS 1734 ILE 1735 0.0466

ILE 1735 PHE 1736 0.0181

PHE 1736 ILE 1737 0.0490

ILE 1737 GLU 1738 0.0207

GLU 1738 ASP 1739 0.0510

ASP 1739 PRO 1740 0.0508

PRO 1740 GLU 1741 -0.0531

GLU 1741 THR 1742 0.0280

THR 1742 ASP 1743 0.0529

ASP 1743 ILE 1744 0.0380

ILE 1744 LEU 1745 0.0525

LEU 1745 SER 1746 0.0505

SER 1746 SER 1747 0.0161

SER 1747 PRO 1748 0.0537

PRO 1748 ASP 1749 0.0259

ASP 1749 GLU 1750 0.0416

GLU 1750 LYS 1751 0.0400

LYS 1751 SER 1752 0.0094

SER 1752 TYR 1753 0.0522

TYR 1753 ALA 1754 0.0496

ALA 1754 SER 1755 0.0193

SER 1755 ILE 1756 0.0363

ILE 1756 GLN 1757 -0.0218

GLN 1757 LYS 1758 0.0415

LYS 1758 LEU 1759 0.0043

LEU 1759 VAL 1760 0.0438

VAL 1760 THR 1761 0.0329

THR 1761 ARG 1762 0.0353

ARG 1762 CYS 1763 0.0049

CYS 1763 LYS 1764 0.0239

LYS 1764 GLY 1765 0.0395

GLY 1765 LEU 1766 0.0445

LEU 1766 ILE 1767 0.0303

ILE 1767 TRP 1768 0.0282

TRP 1768 VAL 1769 0.0332

VAL 1769 SER 1770 0.0412

SER 1770 ARG 1771 0.0400

ARG 1771 GLY 1772 0.0445

GLY 1772 GLY 1773 0.1156

GLY 1773 ALA 1774 0.0189

ALA 1774 MET 1775 0.0159

MET 1775 HIS 1776 0.0294

HIS 1776 GLY 1777 0.0034

GLY 1777 THR 1778 0.0311

THR 1778 ARG 1779 0.0127

ARG 1779 PRO 1780 0.0200

PRO 1780 ASN 1781 0.0205

ASN 1781 SER 1782 0.0131

SER 1782 SER 1783 0.0314

SER 1783 LEU 1784 0.0063

LEU 1784 LYS 1785 0.0258

LYS 1785 THR 1786 0.0183

THR 1786 GLY 1787 0.0134

GLY 1787 LEU 1788 0.0250

LEU 1788 LEU 1789 0.0308

LEU 1789 ARG 1790 0.0395

ARG 1790 THR 1791 0.0055

THR 1791 LEU 1792 0.0396

LEU 1792 ARG 1793 0.0148

ARG 1793 LEU 1794 0.0259

LEU 1794 GLU 1795 0.0183

GLU 1795 TYR 1796 0.0273

TYR 1796 THR 1797 0.0174

THR 1797 GLU 1798 0.0372

GLU 1798 LYS 1799 0.0394

LYS 1799 ARG 1800 0.0153

ARG 1800 PHE 1801 0.0363

PHE 1801 ILE 1802 0.0177

ILE 1802 SER 1803 0.0401

SER 1803 LEU 1804 0.0179

LEU 1804 ASP 1805 0.0697

ASP 1805 LEU 1806 0.0338

LEU 1806 ASP 1807 0.0529

ASP 1807 SER 1808 0.0338

SER 1808 ALA 1809 0.0299

ALA 1809 ARG 1810 0.0435

ARG 1810 PRO 1811 0.0574

PRO 1811 GLN 1812 0.0323

GLN 1812 TRP 1813 0.0442

TRP 1813 ASN 1814 0.0039

ASN 1814 HIS 1815 0.0290

HIS 1815 ASP 1816 0.0592

ASP 1816 SER 1817 0.0058

SER 1817 ILE 1818 0.0557

ILE 1818 THR 1819 0.0268

THR 1819 THR 1820 0.0374

THR 1820 ILE 1821 0.0476

ILE 1821 ASN 1822 0.0209

ASN 1822 GLU 1823 0.0355

GLU 1823 VAL 1824 0.0043

VAL 1824 LEU 1825 0.0380

LEU 1825 CYS 1826 0.0120

CYS 1826 GLY 1827 0.0341

GLY 1827 ALA 1828 0.0094

ALA 1828 LEU 1829 0.0297

LEU 1829 ALA 1830 0.0166

ALA 1830 GLN 1831 0.0264

GLN 1831 ASN 1832 0.0380

ASN 1832 ALA 1833 0.0185

ALA 1833 ASP 1834 0.0361

ASP 1834 SER 1835 0.0383

SER 1835 SER 1836 0.0084

SER 1836 ILE 1837 0.1690

ILE 1837 LYS 1838 0.0346

LYS 1838 ASP 1839 0.0344

ASP 1839 SER 1840 0.0207

SER 1840 GLU 1841 0.0340

GLU 1841 PHE 1842 0.0090

PHE 1842 ALA 1843 0.0322

ALA 1843 GLU 1844 0.0098

GLU 1844 GLN 1845 0.0296

GLN 1845 ASP 1846 0.0068

ASP 1846 GLY 1847 0.0333

GLY 1847 GLN 1848 0.0333

GLN 1848 LEU 1849 0.0144

LEU 1849 PHE 1850 0.0219

PHE 1850 VAL 1851 0.0183

VAL 1851 PRO 1852 0.0137

PRO 1852 ARG 1853 -0.0413

ARG 1853 ILE 1854 0.0148

ILE 1854 SER 1855 0.0240

SER 1855 CYS 1856 0.0171

CYS 1856 ASP 1857 0.0081

ASP 1857 ILE 1858 0.0235

ILE 1858 ALA 1859 0.0101

ALA 1859 ARG 1860 0.0136

ARG 1860 ASN 1861 0.0201

ASN 1861 GLU 1862 0.0242

GLU 1862 ASP 1863 0.0021

ASP 1863 LEU 1864 0.0233

LEU 1864 SER 1865 0.0186

SER 1865 SER 1866 0.0205

SER 1866 ASP 1867 0.0119

ASP 1867 SER 1868 0.0125

SER 1868 ASN 1869 0.4660

ASN 1869 SER 1870 0.0257

SER 1870 PRO 1871 0.0148

PRO 1871 ALA 1872 0.0109

ALA 1872 GLN 1873 0.0261

GLN 1873 MET 1874 0.0059

MET 1874 GLU 1875 0.0263

GLU 1875 PRO 1876 0.0118

PRO 1876 PHE 1877 0.0208

PHE 1877 HIS 1878 0.0260

HIS 1878 GLN 1879 0.0051

GLN 1879 PRO 1880 0.0258

PRO 1880 GLY 1881 0.0181

GLY 1881 LYS 1882 0.0261

LYS 1882 LEU 1883 0.0206

LEU 1883 LEU 1884 0.0248

LEU 1884 GLN 1885 0.1057

GLN 1885 MET 1886 0.0179

MET 1886 GLY 1887 0.0280

GLY 1887 ILE 1888 0.0269

ILE 1888 LYS 1889 0.0289

LYS 1889 THR 1890 0.0297

THR 1890 PRO 1891 0.0311

PRO 1891 GLY 1892 0.0081

GLY 1892 LEU 1893 0.0247

LEU 1893 ILE 1894 0.0258

ILE 1894 ASP 1895 0.0290

ASP 1895 THR 1896 0.0017

THR 1896 LEU 1897 0.0313

LEU 1897 GLN 1898 0.0244

GLN 1898 PHE 1899 0.0221

PHE 1899 SER 1900 0.0037

SER 1900 LYS 1901 0.2171

LYS 1901 THR 1902 0.0031

THR 1902 ASP 1903 0.0087

ASP 1903 ALA 1904 0.0086

ALA 1904 THR 1905 0.0036

THR 1905 ASP 1906 0.0076

ASP 1906 ASN 1907 0.0033

ASN 1907 LEU 1908 0.0090

LEU 1908 PRO 1909 0.0013

PRO 1909 ASN 1910 0.0090

ASN 1910 ASP 1911 0.0090

ASP 1911 TYR 1912 0.0042

TYR 1912 ILE 1913 0.0006

ILE 1913 GLU 1914 0.0039

GLU 1914 ILE 1915 0.0052

ILE 1915 GLU 1916 0.0021

GLU 1916 PRO 1917 0.1198

PRO 1917 LYS 1918 0.0038

LYS 1918 ALA 1919 0.0290

ALA 1919 PHE 1920 0.0282

PHE 1920 GLY 1921 0.0307

GLY 1921 LEU 1922 0.0302

LEU 1922 ASN 1923 0.0276

ASN 1923 PHE 1924 0.0308

PHE 1924 ARG 1925 0.0035

ARG 1925 ASP 1926 0.0309

ASP 1926 VAL 1927 0.0153

VAL 1927 MET 1928 0.0213

MET 1928 VAL 1929 0.0175

VAL 1929 ALA 1930 0.0170

ALA 1930 MET 1931 0.0293

MET 1931 GLY 1932 0.0039

GLY 1932 GLN 1933 0.1761

GLN 1933 LEU 1934 0.0080

LEU 1934 GLU 1935 0.0112

GLU 1935 GLU 1936 0.0381

GLU 1936 SER 1937 0.0338

SER 1937 ILE 1938 0.0406

ILE 1938 MET 1939 0.0185

MET 1939 GLY 1940 0.0410

GLY 1940 PHE 1941 0.0325

PHE 1941 GLU 1942 0.0393

GLU 1942 CYS 1943 0.0393

CYS 1943 ALA 1944 0.0408

ALA 1944 GLY 1945 0.0372

GLY 1945 VAL 1946 0.0256

VAL 1946 VAL 1947 0.0007

VAL 1947 ARG 1948 0.0389

ARG 1948 ARG 1949 -0.0199

ARG 1949 VAL 1950 0.0055

VAL 1950 GLY 1951 0.0021

GLY 1951 PRO 1952 0.0102

PRO 1952 SER 1953 0.0131

SER 1953 SER 1954 0.0047

SER 1954 ALA 1955 0.0148

ALA 1955 GLY 1956 0.0095

GLY 1956 HIS 1957 0.0136

HIS 1957 ASN 1958 0.0045

ASN 1958 ILE 1959 0.0127

ILE 1959 LYS 1960 0.0123

LYS 1960 VAL 1961 0.0108

VAL 1961 GLY 1962 0.0021

GLY 1962 ASP 1963 0.0158

ASP 1963 ARG 1964 0.0114

ARG 1964 VAL 1965 0.1040

VAL 1965 CYS 1966 0.0211

CYS 1966 ALA 1967 0.0063

ALA 1967 LEU 1968 0.0144

LEU 1968 LEU 1969 0.0210

LEU 1969 GLY 1970 0.0079

GLY 1970 GLY 1971 0.0133

GLY 1971 GLN 1972 0.0140

GLN 1972 TRP 1973 0.0005

TRP 1973 THR 1974 0.0222

THR 1974 ASN 1975 0.0121

ASN 1975 THR 1976 0.0105

THR 1976 VAL 1977 0.0118

VAL 1977 ARG 1978 0.0043

ARG 1978 VAL 1979 0.0178

VAL 1979 HIS 1980 0.0102

HIS 1980 TRP 1981 -0.1359

TRP 1981 HIS 1982 0.0313

HIS 1982 SER 1983 0.0121

SER 1983 VAL 1984 0.0193

VAL 1984 ALA 1985 0.0273

ALA 1985 PRO 1986 0.0189

PRO 1986 ILE 1987 0.0058

ILE 1987 PRO 1988 0.0231

PRO 1988 GLN 1989 0.0198

GLN 1989 ALA 1990 0.0138

ALA 1990 MET 1991 0.0313

MET 1991 ASP 1992 0.0262

ASP 1992 TRP 1993 0.0259

TRP 1993 GLU 1994 0.0306

GLU 1994 THR 1995 0.0299

THR 1995 ALA 1996 0.0100

ALA 1996 ALA 1997 0.0327

ALA 1997 SER 1998 0.0491

SER 1998 ILE 1999 0.0202

ILE 1999 PRO 2000 0.0143

PRO 2000 ILE 2001 0.0438

ILE 2001 VAL 2002 0.0425

VAL 2002 PHE 2003 0.0448

PHE 2003 VAL 2004 0.0120

VAL 2004 THR 2005 0.0477

THR 2005 ALA 2006 0.0463

ALA 2006 TYR 2007 0.0382

TYR 2007 ILE 2008 0.0143

ILE 2008 SER 2009 0.0491

SER 2009 LEU 2010 0.0467

LEU 2010 VAL 2011 0.0448

VAL 2011 LYS 2012 0.0195

LYS 2012 ILE 2013 0.1141

ILE 2013 ALA 2014 0.0803

ALA 2014 ARG 2015 0.0888

ARG 2015 MET 2016 0.0423

MET 2016 GLN 2017 0.0894

GLN 2017 ALA 2018 0.0453

ALA 2018 GLY 2019 0.0873

GLY 2019 GLU 2020 0.0791

GLU 2020 THR 2021 0.0641

THR 2021 VAL 2022 0.0849

VAL 2022 LEU 2023 0.0762

LEU 2023 ILE 2024 0.0683

ILE 2024 HIS 2025 0.0836

HIS 2025 ALA 2026 0.0311

ALA 2026 ALA 2027 0.0847

ALA 2027 SER 2028 0.0162

SER 2028 GLY 2029 0.1317

GLY 2029 GLY 2030 0.0689

GLY 2030 VAL 2031 0.0079

VAL 2031 GLY 2032 0.0692

GLY 2032 GLN 2033 0.0424

GLN 2033 ALA 2034 0.0446

ALA 2034 ALA 2035 0.0447

ALA 2035 ILE 2036 0.0409

ILE 2036 ILE 2037 0.0727

ILE 2037 LEU 2038 0.0054

LEU 2038 ALA 2039 0.0733

ALA 2039 LYS 2040 0.0360

LYS 2040 HIS 2041 0.0655

HIS 2041 VAL 2042 0.0160

VAL 2042 GLY 2043 0.0607

GLY 2043 ALA 2044 0.0714

ALA 2044 GLU 2045 0.0636

GLU 2045 ILE 2046 0.0755

ILE 2046 PHE 2047 0.0917

PHE 2047 ALA 2048 0.0708

ALA 2048 THR 2049 0.0880

THR 2049 VAL 2050 0.0317

VAL 2050 GLY 2051 0.0785

GLY 2051 THR 2052 0.0098

THR 2052 ASP 2053 0.0670

ASP 2053 GLU 2054 0.0839

GLU 2054 LYS 2055 0.0106

LYS 2055 ARG 2056 0.0930

ARG 2056 ASP 2057 0.0375

ASP 2057 LEU 2058 0.0834

LEU 2058 LEU 2059 0.0265

LEU 2059 ILE 2060 0.0747

ILE 2060 LYS 2061 0.0178

LYS 2061 GLU 2062 0.0759

GLU 2062 TYR 2063 0.0133

TYR 2063 LYS 2064 0.0978

LYS 2064 ILE 2065 0.0612

ILE 2065 PRO 2066 0.0972

PRO 2066 ASP 2067 0.0835

ASP 2067 ASP 2068 0.0492

ASP 2068 HIS 2069 0.0612

HIS 2069 ILE 2070 0.0839

ILE 2070 PHE 2071 0.0959

PHE 2071 SER 2072 0.0978

SER 2072 SER 2073 0.0656

SER 2073 ARG 2074 0.0955

ARG 2074 ASN 2075 0.0810

ASN 2075 ALA 2076 0.0278

ALA 2076 LEU 2077 0.0750

LEU 2077 PHE 2078 0.1031

PHE 2078 ALA 2079 0.0052

ALA 2079 LYS 2080 0.1017

LYS 2080 SER 2081 0.0373

SER 2081 ILE 2082 0.0835

ILE 2082 ARG 2083 0.0413

ARG 2083 GLN 2084 0.0680

GLN 2084 ARG 2085 0.0845

ARG 2085 THR 2086 0.0275

THR 2086 ASN 2087 0.0931

ASN 2087 GLY 2088 0.0632

GLY 2088 LYS 2089 0.0889

LYS 2089 GLY 2090 0.0887

GLY 2090 VAL 2091 0.0987

VAL 2091 ASP 2092 0.0676

ASP 2092 VAL 2093 0.0451

VAL 2093 VAL 2094 0.0726

VAL 2094 LEU 2095 0.0701

LEU 2095 ASN 2096 0.0857

ASN 2096 CYS 2097 0.0704

CYS 2097 LEU 2098 0.0847

LEU 2098 ALA 2099 0.0612

ALA 2099 GLY 2100 0.0694

GLY 2100 GLY 2101 0.0857

GLY 2101 LEU 2102 0.0582

LEU 2102 LEU 2103 0.0430

LEU 2103 GLN 2104 0.0539

GLN 2104 GLU 2105 0.0501

GLU 2105 SER 2106 0.0847

SER 2106 PHE 2107 0.0010

PHE 2107 ASP 2108 0.0855

ASP 2108 CYS 2109 0.0642

CYS 2109 LEU 2110 0.0485

LEU 2110 ALA 2111 0.0517

ALA 2111 ASP 2112 0.0032

ASP 2112 PHE 2113 0.0660

PHE 2113 GLY 2114 0.0107

GLY 2114 ARG 2115 0.0619

ARG 2115 PHE 2116 0.0543

PHE 2116 ILE 2117 0.0511

ILE 2117 GLU 2118 0.0626

GLU 2118 ILE 2119 0.0332

ILE 2119 GLY 2120 0.0647

GLY 2120 LYS 2121 0.0590

LYS 2121 ARG 2122 0.0661

ARG 2122 ASP 2123 0.0262

ASP 2123 ILE 2124 0.0457

ILE 2124 GLU 2125 -0.0264

GLU 2125 LEU 2126 0.0571

LEU 2126 ASN 2127 0.0114

ASN 2127 HIS 2128 0.0561

HIS 2128 CYS 2129 0.0267

CYS 2129 LEU 2130 0.0578

LEU 2130 ASN 2131 0.0456

ASN 2131 MET 2132 0.0198

MET 2132 GLY 2133 0.0575

GLY 2133 MET 2134 0.0391

MET 2134 PHE 2135 0.0321

PHE 2135 ALA 2136 0.0383

ALA 2136 ARG 2137 0.0350

ARG 2137 SER 2138 0.0558

SER 2138 ALA 2139 0.0103

ALA 2139 THR 2140 0.0552

THR 2140 PHE 2141 0.1649

PHE 2141 THR 2142 0.0521

THR 2142 ALA 2143 0.0399

ALA 2143 VAL 2144 0.0399

VAL 2144 ASP 2145 0.0514

ASP 2145 LEU 2146 0.0440

LEU 2146 ILE 2147 0.0574

ILE 2147 ALA 2148 0.0002

ALA 2148 ILE 2149 0.0575

ILE 2149 GLY 2150 0.0369

GLY 2150 ARG 2151 0.0373

ARG 2151 ASP 2152 0.0119

ASP 2152 ARG 2153 0.0557

ARG 2153 SER 2154 0.0181

SER 2154 TYR 2155 0.0529

TYR 2155 MET 2156 0.0533

MET 2156 PHE 2157 0.0732

PHE 2157 ALA 2158 0.0503

ALA 2158 GLU 2159 0.0515

GLU 2159 ALA 2160 0.0244

ALA 2160 LEU 2161 0.0201

LEU 2161 PRO 2162 0.0528

PRO 2162 LYS 2163 0.0518

LYS 2163 ILE 2164 0.0197

ILE 2164 MET 2165 0.0387

MET 2165 THR 2166 0.0478

THR 2166 LEU 2167 0.0492

LEU 2167 LEU 2168 0.0103

LEU 2168 GLN 2169 0.0522

GLN 2169 GLU 2170 0.0495

GLU 2170 LYS 2171 0.0309

LYS 2171 ALA 2172 0.0243

ALA 2172 ILE 2173 0.0808

ILE 2173 ARG 2174 0.0344

ARG 2174 PRO 2175 0.0422

PRO 2175 VAL 2176 0.0457

VAL 2176 THR 2177 0.0144

THR 2177 PRO 2178 0.0397

PRO 2178 ILE 2179 0.0319

ILE 2179 SER 2180 0.0451

SER 2180 ILE 2181 0.0450

ILE 2181 TYR 2182 0.0410

TYR 2182 LYS 2183 0.0427

LYS 2183 ILE 2184 0.0039

ILE 2184 GLY 2185 0.0407

GLY 2185 ASP 2186 0.0394

ASP 2186 ILE 2187 0.0140

ILE 2187 GLU 2188 0.0454

GLU 2188 THR 2189 0.0411

THR 2189 ALA 2190 0.0324

ALA 2190 PHE 2191 0.0136

PHE 2191 ARG 2192 0.0256

ARG 2192 LEU 2193 0.0238

LEU 2193 MET 2194 0.0141

MET 2194 GLN 2195 0.0320

GLN 2195 ALA 2196 0.0103

ALA 2196 GLY 2197 0.0374

GLY 2197 LYS 2198 0.0030

LYS 2198 HIS 2199 0.0371

HIS 2199 MET 2200 0.0366

MET 2200 GLY 2201 0.0297

GLY 2201 LYS 2202 0.0269

LYS 2202 ILE 2203 0.0376

ILE 2203 VAL 2204 0.0364

VAL 2204 ILE 2205 0.1565

ILE 2205 THR 2206 0.0430

THR 2206 ALA 2207 0.0081

ALA 2207 PRO 2208 0.0439

PRO 2208 GLU 2209 0.0164

GLU 2209 ASP 2210 0.0408

ASP 2210 ALA 2211 0.0438

ALA 2211 MET 2212 0.0165

MET 2212 VAL 2213 0.0420

VAL 2213 PRO 2214 0.0218

PRO 2214 VAL 2215 0.0243

VAL 2215 ILE 2216 0.0160

ILE 2216 THR 2217 0.0198

THR 2217 ARG 2218 0.0377

ARG 2218 PRO 2219 0.0025

PRO 2219 PRO 2220 0.0429

PRO 2220 LYS 2221 0.5606

LYS 2221 LEU 2222 0.0105

LEU 2222 GLN 2223 0.0532

GLN 2223 LEU 2224 0.0127

LEU 2224 ARG 2225 0.0535

ARG 2225 PRO 2226 0.0532

PRO 2226 ASP 2227 0.0431

ASP 2227 ALA 2228 0.0258

ALA 2228 SER 2229 0.0183

SER 2229 TYR 2230 0.0525

TYR 2230 LEU 2231 0.0057

LEU 2231 ILE 2232 0.0508

ILE 2232 VAL 2233 0.0076

VAL 2233 GLY 2234 0.0519

GLY 2234 GLY 2235 0.0219

GLY 2235 LEU 2236 0.0459

LEU 2236 GLY 2237 0.0682

GLY 2237 GLY 2238 0.0180

GLY 2238 ILE 2239 0.0325

ILE 2239 GLY 2240 0.0394

GLY 2240 ARG 2241 0.0345

ARG 2241 SER 2242 0.0139

SER 2242 LEU 2243 0.0417

LEU 2243 CYS 2244 0.0412

CYS 2244 LYS 2245 0.0180

LYS 2245 ASN 2246 0.0284

ASN 2246 PHE 2247 0.0397

PHE 2247 VAL 2248 0.0396

VAL 2248 GLU 2249 0.0121

GLU 2249 ASN 2250 0.0402

ASN 2250 GLY 2251 0.0410

GLY 2251 ALA 2252 0.0016

ALA 2252 ARG 2253 0.0204

ARG 2253 SER 2254 0.0087

SER 2254 LEU 2255 0.0344

LEU 2255 VAL 2256 0.0060

VAL 2256 LEU 2257 0.0428

LEU 2257 LEU 2258 0.0149

LEU 2258 SER 2259 0.0326

SER 2259 ARG 2260 0.0001

ARG 2260 ASN 2261 0.0642

ASN 2261 ALA 2262 0.0288

ALA 2262 ASN 2263 0.0503

ASN 2263 VAL 2264 0.0597

VAL 2264 SER 2265 0.0279

SER 2265 GLN 2266 0.0631

GLN 2266 GLN 2267 0.0594

GLN 2267 SER 2268 0.0327

SER 2268 GLY 2269 0.0736

GLY 2269 GLU 2270 0.0257

GLU 2270 PHE 2271 0.0675

PHE 2271 LEU 2272 0.0691

LEU 2272 ASP 2273 0.0482

ASP 2273 GLU 2274 0.0412

GLU 2274 LEU 2275 0.0698

LEU 2275 ARG 2276 0.0695

ARG 2276 SER 2277 0.0325

SER 2277 THR 2278 0.0499

THR 2278 GLY 2279 0.0690

GLY 2279 CYS 2280 0.0410

CYS 2280 ILE 2281 0.0307

ILE 2281 VAL 2282 0.0246

VAL 2282 GLY 2283 0.0205

GLY 2283 VAL 2284 0.0277

VAL 2284 VAL 2285 0.2997

VAL 2285 ASP 2286 0.0233

ASP 2286 CYS 2287 0.0426

CYS 2287 ASP 2288 0.0417

ASP 2288 ILE 2289 0.0271

ILE 2289 SER 2290 0.0320

SER 2290 SER 2291 0.0183

SER 2291 LYS 2292 0.0418

LYS 2292 THR 2293 0.0247

THR 2293 GLN 2294 0.0343

GLN 2294 VAL 2295 0.0086

VAL 2295 GLU 2296 0.0380

GLU 2296 ALA 2297 0.0346

ALA 2297 THR 2298 0.0138

THR 2298 MET 2299 0.0279

MET 2299 LEU 2300 0.0275

LEU 2300 ARG 2301 0.0988

ARG 2301 LEU 2302 0.0070

LEU 2302 LYS 2303 0.0304

LYS 2303 LYS 2304 0.0327

LYS 2304 ASP 2305 0.0325

ASP 2305 MET 2306 0.0138

MET 2306 LEU 2307 0.0088

LEU 2307 PRO 2308 0.0341

PRO 2308 ILE 2309 0.0327

ILE 2309 ARG 2310 0.0137

ARG 2310 GLY 2311 0.0328

GLY 2311 ILE 2312 0.0142

ILE 2312 VAL 2313 0.0339

VAL 2313 HIS 2314 0.0063

HIS 2314 ALA 2315 0.0339

ALA 2315 GLY 2316 0.0002

GLY 2316 MET 2317 0.1542

MET 2317 VAL 2318 0.0191

VAL 2318 LEU 2319 0.0361

LEU 2319 GLN 2320 0.0286

GLN 2320 ASP 2321 0.0301

ASP 2321 SER 2322 0.0361

SER 2322 VAL 2323 0.0223

VAL 2323 PHE 2324 0.0324

PHE 2324 GLU 2325 0.0292

GLU 2325 ARG 2326 0.0084

ARG 2326 MET 2327 0.0351

MET 2327 SER 2328 0.0223

SER 2328 LEU 2329 0.0329

LEU 2329 ASP 2330 0.0236

ASP 2330 ASP 2331 0.0307

ASP 2331 TYR 2332 0.0065

TYR 2332 ASN 2333 0.2074

ASN 2333 THR 2334 0.0185

THR 2334 ALA 2335 0.0019

ALA 2335 ILE 2336 0.0147

ILE 2336 ARG 2337 0.0146

ARG 2337 PRO 2338 0.0144

PRO 2338 LYS 2339 0.0034

LYS 2339 VAL 2340 0.0183

VAL 2340 GLN 2341 0.0099

GLN 2341 GLY 2342 0.0181

GLY 2342 SER 2343 0.0004

SER 2343 TRP 2344 0.0181

TRP 2344 ASN 2345 0.0103

ASN 2345 LEU 2346 0.0109

LEU 2346 HIS 2347 0.0091

HIS 2347 SER 2348 0.0123

SER 2348 GLY 2349 0.0076

GLY 2349 LEU 2350 0.0011

LEU 2350 SER 2351 0.0178

SER 2351 ASP 2352 0.0188

ASP 2352 CYS 2353 0.0139

CYS 2353 ASP 2354 0.0002

ASP 2354 LEU 2355 0.0194

LEU 2355 ASP 2356 0.0054

ASP 2356 PHE 2357 0.0158

PHE 2357 PHE 2358 0.0060

PHE 2358 ILE 2359 0.0194

ILE 2359 MET 2360 0.0090

MET 2360 LEU 2361 0.0193

LEU 2361 SER 2362 0.0181

SER 2362 SER 2363 0.0194

SER 2363 LEU 2364 0.0145

LEU 2364 ALA 2365 -0.1745

ALA 2365 GLY 2366 0.0200

GLY 2366 VAL 2367 0.0025

VAL 2367 SER 2368 0.0217

SER 2368 GLY 2369 0.0092

GLY 2369 SER 2370 0.0075

SER 2370 ALA 2371 0.0160

ALA 2371 SER 2372 0.0036

SER 2372 GLN 2373 0.0206

GLN 2373 ALA 2374 0.0190

ALA 2374 ASN 2375 0.0157

ASN 2375 TYR 2376 0.0202

TYR 2376 THR 2377 0.0019

THR 2377 ALA 2378 0.0220

ALA 2378 GLY 2379 0.0191

GLY 2379 GLY 2380 0.0103

GLY 2380 ALA 2381 0.0008

ALA 2381 TYR 2382 0.0129

TYR 2382 GLN 2383 0.0151

GLN 2383 ASP 2384 0.0019

ASP 2384 ALA 2385 0.0166

ALA 2385 LEU 2386 0.0134

LEU 2386 ALA 2387 0.0071

ALA 2387 LYS 2388 0.0100

LYS 2388 TYR 2389 0.0110

TYR 2389 ARG 2390 0.0167

ARG 2390 ARG 2391 0.0002

ARG 2391 ALA 2392 0.0163

ALA 2392 GLN 2393 0.0118

GLN 2393 GLY 2394 0.0111

GLY 2394 LEU 2395 0.0085

LEU 2395 SER 2396 0.0163

SER 2396 ALA 2397 0.0647

ALA 2397 VAL 2398 0.0264

VAL 2398 SER 2399 0.0122

SER 2399 ILE 2400 0.0265

ILE 2400 ASP 2401 0.0186

ASP 2401 LEU 2402 0.0244

LEU 2402 GLY 2403 0.0252

GLY 2403 MET 2404 0.0162

MET 2404 VAL 2405 0.0256

VAL 2405 GLN 2406 0.0255

GLN 2406 SER 2407 0.0263

SER 2407 VAL 2408 0.0220

VAL 2408 GLY 2409 0.0153

GLY 2409 TYR 2410 0.0135

TYR 2410 VAL 2411 0.0231

VAL 2411 ALA 2412 0.0261

ALA 2412 GLU 2413 -0.0918

GLU 2413 THR 2414 0.0112

THR 2414 LYS 2415 0.0150

LYS 2415 GLY 2416 0.0148

GLY 2416 VAL 2417 0.0108

VAL 2417 ALA 2418 0.0029

ALA 2418 GLU 2419 0.0147

GLU 2419 ARG 2420 0.0135

ARG 2420 LEU 2421 0.0052

LEU 2421 VAL 2422 0.0097

VAL 2422 ARG 2423 0.0118

ARG 2423 MET 2424 0.0153

MET 2424 GLY 2425 0.0002

GLY 2425 TYR 2426 0.0153

TYR 2426 SER 2427 0.0089

SER 2427 PRO 2428 0.0145

PRO 2428 ILE 2429 -0.0514

ILE 2429 SER 2430 0.0233

SER 2430 GLU 2431 0.0246

GLU 2431 MET 2432 0.0041

MET 2432 GLU 2433 0.0263

GLU 2433 VAL 2434 0.0057

VAL 2434 LEU 2435 0.0227

LEU 2435 LYS 2436 0.0097

LYS 2436 ILE 2437 0.0176

ILE 2437 VAL 2438 0.0191

VAL 2438 GLU 2439 0.0081

GLU 2439 HIS 2440 0.0232

HIS 2440 ALA 2441 0.0063

ALA 2441 ILE 2442 0.0260

ILE 2442 THR 2443 0.0018

THR 2443 ASN 2444 0.0265

ASN 2444 PRO 2445 0.1832

PRO 2445 PRO 2446 0.0088

PRO 2446 PRO 2447 0.0077

PRO 2447 GLU 2448 0.0097

GLU 2448 ALA 2449 0.0020

ALA 2449 SER 2450 0.0091

SER 2450 SER 2451 0.0099

SER 2451 ALA 2452 0.0018

ALA 2452 GLN 2453 0.0096

GLN 2453 ILE 2454 0.0095

ILE 2454 ILE 2455 0.0101

ILE 2455 THR 2456 0.0100

THR 2456 GLY 2457 0.0098

GLY 2457 ILE 2458 0.0074

ILE 2458 SER 2459 0.0076

SER 2459 THR 2460 0.0005

THR 2460 LYS 2461 -0.0671

LYS 2461 PRO 2462 0.0085

PRO 2462 GLY 2463 0.0013

GLY 2463 ARG 2464 0.0035

ARG 2464 HIS 2465 0.0075

HIS 2465 TRP 2466 0.0040

TRP 2466 THR 2467 0.0068

THR 2467 GLU 2468 0.0008

GLU 2468 SER 2469 0.0082

SER 2469 SER 2470 0.0080

SER 2470 TRP 2471 0.0075

TRP 2471 LEU 2472 0.0018

LEU 2472 GLN 2473 0.0082

GLN 2473 ASP 2474 0.0084

ASP 2474 ALA 2475 0.0018

ALA 2475 ARG 2476 0.0083

ARG 2476 PHE 2477 -0.1233

PHE 2477 ALA 2478 0.0026

ALA 2478 THR 2479 0.0030

THR 2479 LEU 2480 0.0015

LEU 2480 ARG 2481 0.0040

ARG 2481 GLU 2482 0.0013

GLU 2482 ARG 2483 0.0045

ARG 2483 ALA 2484 0.0006

ALA 2484 ARG 2485 0.0036

ARG 2485 ASP 2486 0.0022

ASP 2486 VAL 2487 0.0025

VAL 2487 LYS 2488 0.0034

LYS 2488 GLU 2489 0.0016

GLU 2489 LEU 2490 0.0040

LEU 2490 SER 2491 0.0014

SER 2491 ASN 2492 0.0041

ASN 2492 SER 2493 -0.0041

SER 2493 GLN 2494 0.0136

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** sdgklnrdh ***

CA strain for 22101813491974862

--- normal mode 26 ---

Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *