Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *

CA strain for 22101813491974862

--- normal mode 25 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
ASN 989 LYS 990 0.0600

LYS 990 ALA 991 0.0082

ALA 991 HIS 992 0.0558

HIS 992 ARG 993 0.0287

ARG 993 GLN 994 0.0407

GLN 994 ARG 995 0.0262

ARG 995 VAL 996 0.0506

VAL 996 HIS 997 0.0393

HIS 997 PRO 998 0.0555

PRO 998 PRO 999 0.0434

PRO 999 HIS 1000 0.0179

HIS 1000 ASP 1001 0.0514

ASP 1001 LEU 1002 0.0124

LEU 1002 LEU 1003 0.0580

LEU 1003 GLY 1004 0.0117

GLY 1004 SER 1005 -0.0668

SER 1005 LEU 1006 0.0337

LEU 1006 ILE 1007 0.0372

ILE 1007 VAL 1008 0.0267

VAL 1008 GLY 1009 0.0379

GLY 1009 ARG 1010 0.0010

ARG 1010 ASP 1011 0.0229

ASP 1011 LEU 1012 0.0379

LEU 1012 ARG 1013 0.0046

ARG 1013 GLU 1014 0.0400

GLU 1014 PRO 1015 0.0213

PRO 1015 THR 1016 0.0368

THR 1016 TRP 1017 0.0305

TRP 1017 ARG 1018 0.0281

ARG 1018 HIS 1019 0.0394

HIS 1019 PHE 1020 0.0288

PHE 1020 ILE 1021 0.2409

ILE 1021 ARG 1022 0.0487

ARG 1022 VAL 1023 0.0177

VAL 1023 GLN 1024 0.0333

GLN 1024 ASP 1025 0.0414

ASP 1025 ILE 1026 0.0121

ILE 1026 PRO 1027 0.0244

PRO 1027 TRP 1028 0.0213

TRP 1028 ILE 1029 0.0487

ILE 1029 ARG 1030 0.0391

ARG 1030 ASP 1031 0.0167

ASP 1031 HIS 1032 0.0485

HIS 1032 VAL 1033 0.0429

VAL 1033 VAL 1034 0.0396

VAL 1034 GLN 1035 0.0420

GLN 1035 SER 1036 0.0390

SER 1036 ALA 1037 0.0113

ALA 1037 LEU 1038 0.0217

LEU 1038 VAL 1039 0.0370

VAL 1039 TYR 1040 0.0236

TYR 1040 PRO 1041 0.0234

PRO 1041 GLY 1042 0.0366

GLY 1042 ALA 1043 0.0364

ALA 1043 GLY 1044 0.0063

GLY 1044 PHE 1045 0.0344

PHE 1045 ILE 1046 0.0356

ILE 1046 CYS 1047 0.0284

CYS 1047 MET 1048 0.0146

MET 1048 ALA 1049 0.0370

ALA 1049 MET 1050 0.0373

MET 1050 GLU 1051 0.0165

GLU 1051 ALA 1052 0.0277

ALA 1052 MET 1053 0.1287

MET 1053 VAL 1054 0.0236

VAL 1054 GLN 1055 0.0070

GLN 1055 LEU 1056 0.0282

LEU 1056 HIS 1057 0.0274

HIS 1057 GLU 1058 0.0129

GLU 1058 LEU 1059 0.0182

LEU 1059 ARG 1060 0.0267

ARG 1060 ASP 1061 0.0269

ASP 1061 SER 1062 0.0129

SER 1062 GLN 1063 0.0172

GLN 1063 SER 1064 0.0181

SER 1064 ARG 1065 0.0057

ARG 1065 LYS 1066 0.0160

LYS 1066 VAL 1067 0.0173

VAL 1067 ALA 1068 0.0022

ALA 1068 GLY 1069 0.0544

GLY 1069 TYR 1070 0.0327

TYR 1070 ARG 1071 0.0210

ARG 1071 LEU 1072 0.0312

LEU 1072 ALA 1073 0.0235

ALA 1073 GLU 1074 0.0294

GLU 1074 VAL 1075 0.0314

VAL 1075 ASP 1076 0.0314

ASP 1076 ILE 1077 0.0325

ILE 1077 LEU 1078 0.0322

LEU 1078 ARG 1079 0.0319

ARG 1079 ALA 1080 0.0324

ALA 1080 MET 1081 0.0057

MET 1081 LEU 1082 0.0325

LEU 1082 ILE 1083 0.0197

ILE 1083 PRO 1084 0.0287

PRO 1084 ASP 1085 0.0291

ASP 1085 THR 1086 0.0084

THR 1086 SER 1087 0.0173

SER 1087 GLU 1088 0.0345

GLU 1088 GLY 1089 0.0017

GLY 1089 LEU 1090 0.0206

LEU 1090 GLU 1091 0.0362

GLU 1091 ALA 1092 0.0098

ALA 1092 HIS 1093 0.0345

HIS 1093 ILE 1094 0.0182

ILE 1094 SER 1095 0.0355

SER 1095 LEU 1096 0.0237

LEU 1096 ARG 1097 0.0315

ARG 1097 PRO 1098 0.0253

PRO 1098 CYS 1099 0.0052

CYS 1099 SER 1100 0.0354

SER 1100 THR 1101 -0.1712

THR 1101 LYS 1102 0.0145

LYS 1102 LEU 1103 0.0194

LEU 1103 LEU 1104 0.0092

LEU 1104 LEU 1105 0.0192

LEU 1105 THR 1106 0.0223

THR 1106 ASN 1107 0.0079

ASN 1107 GLU 1108 0.0020

GLU 1108 TRP 1109 0.0226

TRP 1109 TYR 1110 0.0084

TYR 1110 ASP 1111 0.0225

ASP 1111 PHE 1112 0.0148

PHE 1112 CYS 1113 0.0185

CYS 1113 VAL 1114 0.0171

VAL 1114 SER 1115 0.0140

SER 1115 SER 1116 0.0089

SER 1116 VAL 1117 0.0379

VAL 1117 GLY 1118 0.0288

GLY 1118 ASP 1119 0.0110

ASP 1119 ASP 1120 0.0282

ASP 1120 ASP 1121 0.0284

ASP 1121 LYS 1122 0.0024

LYS 1122 PHE 1123 0.0206

PHE 1123 VAL 1124 0.0081

VAL 1124 ASP 1125 0.0163

ASP 1125 HIS 1126 0.0236

HIS 1126 CYS 1127 0.0220

CYS 1127 ARG 1128 0.0268

ARG 1128 GLY 1129 0.0217

GLY 1129 ARG 1130 0.0288

ARG 1130 ILE 1131 0.0252

ILE 1131 THR 1132 0.0289

THR 1132 ILE 1133 0.1190

ILE 1133 GLU 1134 0.0209

GLU 1134 PHE 1135 0.0058

PHE 1135 ASP 1136 0.0203

ASP 1136 THR 1137 0.0151

THR 1137 SER 1138 0.0123

SER 1138 GLY 1139 0.0227

GLY 1139 SER 1140 0.0030

SER 1140 ALA 1141 0.0203

ALA 1141 ASP 1142 0.0017

ASP 1142 THR 1143 0.0161

THR 1143 PRO 1144 0.0144

PRO 1144 ARG 1145 0.0090

ARG 1145 THR 1146 0.0119

THR 1146 SER 1147 0.0193

SER 1147 LEU 1148 0.0020

LEU 1148 ARG 1149 0.0867

ARG 1149 GLU 1150 0.1214

GLU 1150 ARG 1151 0.1065

ARG 1151 SER 1152 0.0319

SER 1152 ARG 1153 0.1332

ARG 1153 SER 1154 0.0865

SER 1154 THR 1155 0.0311

THR 1155 GLY 1156 0.0642

GLY 1156 LEU 1157 0.0691

LEU 1157 MET 1158 0.1298

MET 1158 ARG 1159 0.0657

ARG 1159 SER 1160 0.1346

SER 1160 VAL 1161 0.1302

VAL 1161 ASP 1162 0.1306

ASP 1162 PRO 1163 0.0799

PRO 1163 SER 1164 0.0670

SER 1164 ASN 1165 -0.1906

ASN 1165 LEU 1166 0.0311

LEU 1166 TYR 1167 0.0398

TYR 1167 SER 1168 0.0349

SER 1168 PHE 1169 0.0626

PHE 1169 LEU 1170 0.0043

LEU 1170 ARG 1171 0.0641

ARG 1171 ALA 1172 0.0291

ALA 1172 GLN 1173 0.0509

GLN 1173 GLY 1174 0.0216

GLY 1174 ILE 1175 0.0509

ILE 1175 TYR 1176 0.0634

TYR 1176 HIS 1177 0.0573

HIS 1177 GLY 1178 0.0627

GLY 1178 PRO 1179 0.0643

PRO 1179 ILE 1180 0.0185

ILE 1180 PHE 1181 0.1398

PHE 1181 GLN 1182 0.0173

GLN 1182 ASN 1183 0.0592

ASN 1183 LEU 1184 0.0382

LEU 1184 LYS 1185 0.0519

LYS 1185 THR 1186 0.0490

THR 1186 ILE 1187 0.0637

ILE 1187 SER 1188 0.0578

SER 1188 SER 1189 0.0663

SER 1189 ARG 1190 0.0576

ARG 1190 LYS 1191 0.0682

LYS 1191 ASP 1192 0.0065

ASP 1192 HIS 1193 0.0539

HIS 1193 SER 1194 0.0681

SER 1194 GLU 1195 0.0571

GLU 1195 SER 1196 0.0644

SER 1196 SER 1197 -0.0417

SER 1197 PHE 1198 0.0301

PHE 1198 VAL 1199 0.0309

VAL 1199 VAL 1200 0.0029

VAL 1200 ALA 1201 0.0534

ALA 1201 ASN 1202 0.0361

ASN 1202 THR 1203 0.0395

THR 1203 ALA 1204 0.0242

ALA 1204 SER 1205 0.0332

SER 1205 VAL 1206 0.0536

VAL 1206 MET 1207 0.0024

MET 1207 PRO 1208 0.0331

PRO 1208 ASN 1209 0.0501

ASN 1209 GLY 1210 0.0385

GLY 1210 PHE 1211 0.0222

PHE 1211 GLN 1212 0.0526

GLN 1212 SER 1213 0.0890

SER 1213 PRO 1214 0.0461

PRO 1214 HIS 1215 0.0355

HIS 1215 VAL 1216 0.0412

VAL 1216 ILE 1217 0.0101

ILE 1217 HIS 1218 0.0430

HIS 1218 PRO 1219 0.0399

PRO 1219 THR 1220 0.0161

THR 1220 THR 1221 0.0462

THR 1221 LEU 1222 0.0461

LEU 1222 ASP 1223 0.0322

ASP 1223 SER 1224 0.0234

SER 1224 ILE 1225 0.0470

ILE 1225 PHE 1226 0.0469

PHE 1226 GLN 1227 0.0193

GLN 1227 GLY 1228 0.0408

GLY 1228 ALA 1229 -0.0073

ALA 1229 TYR 1230 0.0204

TYR 1230 THR 1231 0.0475

THR 1231 ALA 1232 0.0593

ALA 1232 LEU 1233 0.0439

LEU 1233 PRO 1234 0.0002

PRO 1234 GLY 1235 0.0526

GLY 1235 ALA 1236 0.0086

ALA 1236 GLY 1237 0.0567

GLY 1237 LEU 1238 0.0305

LEU 1238 ASP 1239 0.0486

ASP 1239 GLN 1240 0.0240

GLN 1240 ASN 1241 0.0587

ASN 1241 THR 1242 0.0040

THR 1242 ALA 1243 0.0183

ALA 1243 MET 1244 0.0397

MET 1244 ILE 1245 0.0928

ILE 1245 PRO 1246 0.0274

PRO 1246 ARG 1247 0.0364

ARG 1247 SER 1248 0.0357

SER 1248 ILE 1249 0.0410

ILE 1249 GLN 1250 0.0411

GLN 1250 GLU 1251 0.0352

GLU 1251 LEU 1252 0.0411

LEU 1252 TYR 1253 0.0361

TYR 1253 LEU 1254 0.0392

LEU 1254 SER 1255 0.0394

SER 1255 SER 1256 0.0182

SER 1256 ALA 1257 0.0250

ALA 1257 LEU 1258 0.0327

LEU 1258 THR 1259 0.0405

THR 1259 SER 1260 0.0417

SER 1260 ASP 1261 0.1369

ASP 1261 VAL 1262 0.0360

VAL 1262 GLY 1263 0.0062

GLY 1263 GLN 1264 0.0583

GLN 1264 CYS 1265 0.0178

CYS 1265 LEU 1266 0.0586

LEU 1266 VAL 1267 0.0283

VAL 1267 SER 1268 0.0589

SER 1268 ASP 1269 0.0444

ASP 1269 THR 1270 0.0571

THR 1270 SER 1271 0.0516

SER 1271 LEU 1272 0.0523

LEU 1272 ILE 1273 0.0508

ILE 1273 ARG 1274 0.0510

ARG 1274 TYR 1275 0.0432

TYR 1275 ASP 1276 0.0533

ASP 1276 GLY 1277 0.1153

GLY 1277 GLN 1278 0.0165

GLN 1278 SER 1279 0.0331

SER 1279 PHE 1280 0.0554

PHE 1280 THR 1281 0.0317

THR 1281 VAL 1282 0.0552

VAL 1282 ASN 1283 0.0378

ASN 1283 VAL 1284 0.0531

VAL 1284 ASP 1285 0.0496

ASP 1285 VAL 1286 0.0526

VAL 1286 SER 1287 0.0544

SER 1287 SER 1288 0.0544

SER 1288 LYS 1289 0.0165

LYS 1289 ALA 1290 0.0403

ALA 1290 ASP 1291 0.0507

ASP 1291 SER 1292 0.0371

SER 1292 GLU 1293 0.0976

GLU 1293 HIS 1294 0.0512

HIS 1294 THR 1295 0.0148

THR 1295 PRO 1296 0.0530

PRO 1296 VAL 1297 0.0288

VAL 1297 LEU 1298 0.0508

LEU 1298 GLU 1299 0.0463

GLU 1299 ILE 1300 0.0487

ILE 1300 LYS 1301 0.0500

LYS 1301 GLY 1302 0.0426

GLY 1302 LEU 1303 0.0528

LEU 1303 ARG 1304 0.0444

ARG 1304 ASN 1305 0.0425

ASN 1305 GLN 1306 0.0501

GLN 1306 SER 1307 0.0354

SER 1307 VAL 1308 0.0445

VAL 1308 GLY 1309 0.0371

GLY 1309 GLN 1310 0.0386

GLN 1310 MET 1311 0.0047

MET 1311 ALA 1312 0.0376

ALA 1312 PRO 1313 0.0517

PRO 1313 GLN 1314 0.0066

GLN 1314 PRO 1315 0.0323

PRO 1315 GLY 1316 0.0534

GLY 1316 ASP 1317 0.0075

ASP 1317 SER 1318 0.0439

SER 1318 SER 1319 0.0310

SER 1319 ASN 1320 0.0444

ASN 1320 ASN 1321 0.0403

ASN 1321 ASP 1322 0.0412

ASP 1322 LEU 1323 0.0328

LEU 1323 CYS 1324 0.0537

CYS 1324 PHE 1325 0.0645

PHE 1325 LYS 1326 0.0143

LYS 1326 LEU 1327 0.0217

LEU 1327 ASP 1328 0.0175

ASP 1328 TRP 1329 0.0216

TRP 1329 ALA 1330 0.0214

ALA 1330 PRO 1331 0.0221

PRO 1331 ASP 1332 0.0057

ASP 1332 ILE 1333 0.0219

ILE 1333 SER 1334 0.0139

SER 1334 SER 1335 0.0126

SER 1335 VAL 1336 0.0054

VAL 1336 LYS 1337 0.0140

LYS 1337 GLN 1338 0.0185

GLN 1338 GLU 1339 0.0023

GLU 1339 ARG 1340 0.0221

ARG 1340 LEU 1341 0.4346

LEU 1341 LYS 1342 0.0243

LYS 1342 GLU 1343 0.0512

GLU 1343 LYS 1344 0.0516

LYS 1344 PHE 1345 0.0307

PHE 1345 GLY 1346 0.0350

GLY 1346 PHE 1347 0.0049

PHE 1347 PRO 1348 0.0403

PRO 1348 LEU 1349 0.0098

LEU 1349 ASP 1350 0.0247

ASP 1350 PRO 1351 0.0229

PRO 1351 THR 1352 0.0300

THR 1352 GLU 1353 0.0451

GLU 1353 ALA 1354 0.0515

ALA 1354 ASP 1355 0.0024

ASP 1355 ILE 1356 0.0511

ILE 1356 ILE 1357 0.3765

ILE 1357 MET 1358 0.1604

MET 1358 GLY 1359 0.2119

GLY 1359 LEU 1360 0.1217

LEU 1360 ARG 1361 0.2757

ARG 1361 GLN 1362 0.0279

GLN 1362 ALA 1363 0.2803

ALA 1363 CYS 1364 0.1085

CYS 1364 ILE 1365 0.2393

ILE 1365 HIS 1366 0.1322

HIS 1366 PHE 1367 0.1992

PHE 1367 ILE 1368 0.2162

ILE 1368 HIS 1369 0.1198

HIS 1369 ARG 1370 0.2404

ARG 1370 SER 1371 0.1025

SER 1371 LEU 1372 0.2744

LEU 1372 GLN 1373 0.0384

GLN 1373 SER 1374 0.3164

SER 1374 LEU 1375 0.0638

LEU 1375 THR 1376 0.3169

THR 1376 ALA 1377 0.1928

ALA 1377 PRO 1378 0.2819

PRO 1378 ASP 1379 0.3174

ASP 1379 ARG 1380 0.2465

ARG 1380 ASP 1381 0.2076

ASP 1381 GLN 1382 0.3101

GLN 1382 LEU 1383 0.3081

LEU 1383 ASP 1384 0.0656

ASP 1384 TRP 1385 0.2237

TRP 1385 HIS 1386 0.3051

HIS 1386 GLN 1387 0.0204

GLN 1387 LYS 1388 0.3157

LYS 1388 ARG 1389 0.1333

ARG 1389 PHE 1390 0.1352

PHE 1390 TYR 1391 0.2242

TYR 1391 ASP 1392 0.2638

ASP 1392 TRP 1393 0.2998

TRP 1393 MET 1394 0.0371

MET 1394 VAL 1395 0.2997

VAL 1395 LEU 1396 0.2640

LEU 1396 GLN 1397 0.2140

GLN 1397 ILE 1398 0.1299

ILE 1398 GLN 1399 0.2754

GLN 1399 LEU 1400 0.2983

LEU 1400 ALA 1401 0.0580

ALA 1401 GLU 1402 0.2717

GLU 1402 GLU 1403 0.2368

GLU 1403 ASP 1404 0.2718

ASP 1404 ARG 1405 -0.1362

ARG 1405 LEU 1406 0.3046

LEU 1406 ALA 1407 0.2031

ALA 1407 PRO 1408 0.1776

PRO 1408 ASN 1409 0.1687

ASN 1409 SER 1410 0.2430

SER 1410 SER 1411 0.2634

SER 1411 ALA 1412 0.1066

ALA 1412 TRP 1413 0.2572

TRP 1413 LEU 1414 0.3045

LEU 1414 GLN 1415 0.0021

GLN 1415 CYS 1416 0.2954

CYS 1416 SER 1417 0.1416

SER 1417 SER 1418 0.2942

SER 1418 SER 1419 0.2509

SER 1419 ASP 1420 0.2367

ASP 1420 GLU 1421 0.0773

GLU 1421 GLN 1422 0.2709

GLN 1422 LYS 1423 0.2716

LYS 1423 LEU 1424 0.1107

LEU 1424 LEU 1425 0.2104

LEU 1425 GLU 1426 0.2509

GLU 1426 ASN 1427 0.2656

ASN 1427 VAL 1428 0.0660

VAL 1428 ARG 1429 0.2666

ARG 1429 ALA 1430 0.2603

ALA 1430 SER 1431 0.2281

SER 1431 SER 1432 0.0368

SER 1432 VAL 1433 0.1768

VAL 1433 ASN 1434 0.2721

ASN 1434 GLY 1435 0.0178

GLY 1435 GLN 1436 0.2736

GLN 1436 MET 1437 0.1023

MET 1437 VAL 1438 0.2313

VAL 1438 VAL 1439 0.0785

VAL 1439 HIS 1440 0.2245

HIS 1440 VAL 1441 0.1893

VAL 1441 GLY 1442 0.1706

GLY 1442 LYS 1443 0.1459

LYS 1443 SER 1444 0.1733

SER 1444 MET 1445 0.2273

MET 1445 LEU 1446 0.2279

LEU 1446 ALA 1447 0.2552

ALA 1447 ILE 1448 0.0402

ILE 1448 LEU 1449 0.2668

LEU 1449 ARG 1450 0.2440

ARG 1450 HIS 1451 0.1476

HIS 1451 GLU 1452 0.1587

GLU 1452 ILE 1453 0.5301

ILE 1453 ALA 1454 0.0551

ALA 1454 PRO 1455 0.2294

PRO 1455 LEU 1456 0.1323

LEU 1456 GLU 1457 0.2050

GLU 1457 LEU 1458 0.0532

LEU 1458 MET 1459 0.2054

MET 1459 LEU 1460 0.1914

LEU 1460 GLN 1461 0.0736

GLN 1461 ASP 1462 0.2155

ASP 1462 LYS 1463 0.0791

LYS 1463 LEU 1464 0.1863

LEU 1464 LEU 1465 0.0764

LEU 1465 TYR 1466 0.1995

TYR 1466 ARG 1467 0.0938

ARG 1467 TYR 1468 0.2316

TYR 1468 TYR 1469 0.2790

TYR 1469 THR 1470 0.0833

THR 1470 ASP 1471 0.0201

ASP 1471 ALA 1472 0.0684

ALA 1472 ILE 1473 0.0806

ILE 1473 LYS 1474 0.0408

LYS 1474 TRP 1475 0.0407

TRP 1475 ASP 1476 0.0773

ASP 1476 ARG 1477 0.0826

ARG 1477 SER 1478 0.0578

SER 1478 TYR 1479 0.0625

TYR 1479 GLN 1480 0.0828

GLN 1480 GLN 1481 0.0750

GLN 1481 ILE 1482 0.0539

ILE 1482 ASP 1483 0.0777

ASP 1483 GLN 1484 0.0785

GLN 1484 LEU 1485 0.3277

LEU 1485 VAL 1486 0.0122

VAL 1486 LYS 1487 0.0026

LYS 1487 LEU 1488 0.0112

LEU 1488 HIS 1489 0.0103

HIS 1489 ALA 1490 0.0103

ALA 1490 HIS 1491 0.0026

HIS 1491 LYS 1492 0.0122

LYS 1492 CYS 1493 0.0102

CYS 1493 PRO 1494 0.0118

PRO 1494 THR 1495 0.0109

THR 1495 ALA 1496 0.0025

ALA 1496 LYS 1497 0.0046

LYS 1497 ILE 1498 0.0064

ILE 1498 ILE 1499 0.0001

ILE 1499 GLU 1500 0.0073

GLU 1500 ILE 1501 0.2350

ILE 1501 GLY 1502 0.0059

GLY 1502 ALA 1503 0.0214

ALA 1503 GLY 1504 0.0085

GLY 1504 THR 1505 0.0195

THR 1505 GLY 1506 0.0101

GLY 1506 GLY 1507 0.0149

GLY 1507 CYS 1508 0.0118

CYS 1508 THR 1509 0.0094

THR 1509 ARG 1510 0.0209

ARG 1510 ALA 1511 0.0216

ALA 1511 VAL 1512 0.0069

VAL 1512 LEU 1513 0.0174

LEU 1513 ASP 1514 0.0199

ASP 1514 ALA 1515 0.0181

ALA 1515 LEU 1516 0.0075

LEU 1516 SER 1517 -0.1362

SER 1517 ASN 1518 0.0049

ASN 1518 GLN 1519 0.0054

GLN 1519 GLY 1520 0.0056

GLY 1520 ILE 1521 0.0020

ILE 1521 ALA 1522 0.0055

ALA 1522 ARG 1523 0.0050

ARG 1523 CYS 1524 0.0055

CYS 1524 ALA 1525 0.0034

ALA 1525 GLN 1526 0.0029

GLN 1526 TYR 1527 0.0001

TYR 1527 ASP 1528 0.0052

ASP 1528 PHE 1529 0.0003

PHE 1529 THR 1530 0.0050

THR 1530 ASP 1531 0.0014

ASP 1531 VAL 1532 0.0052

VAL 1532 SER 1533 -0.0797

SER 1533 SER 1534 0.0110

SER 1534 GLY 1535 0.0045

GLY 1535 PHE 1536 0.0153

PHE 1536 PHE 1537 0.0003

PHE 1537 GLU 1538 0.0154

GLU 1538 ALA 1539 0.0090

ALA 1539 ALA 1540 0.0111

ALA 1540 GLN 1541 0.0044

GLN 1541 GLN 1542 0.0126

GLN 1542 LYS 1543 0.0135

LYS 1543 PHE 1544 0.0039

PHE 1544 ALA 1545 0.0089

ALA 1545 ALA 1546 0.0135

ALA 1546 PHE 1547 0.0137

PHE 1547 ASP 1548 0.0142

ASP 1548 ASP 1549 0.1546

ASP 1549 VAL 1550 0.0166

VAL 1550 ILE 1551 0.0072

ILE 1551 ARG 1552 0.0170

ARG 1552 PHE 1553 0.0061

PHE 1553 GLN 1554 0.0169

GLN 1554 LYS 1555 0.0132

LYS 1555 LEU 1556 0.0149

LEU 1556 ASP 1557 0.0155

ASP 1557 ILE 1558 0.0123

ILE 1558 GLU 1559 0.0166

GLU 1559 LYS 1560 0.0134

LYS 1560 ASP 1561 0.0007

ASP 1561 ILE 1562 0.0158

ILE 1562 GLU 1563 0.0088

GLU 1563 MET 1564 0.0100

MET 1564 GLN 1565 0.0098

GLN 1565 GLY 1566 0.0162

GLY 1566 PHE 1567 0.0212

PHE 1567 GLU 1568 0.0122

GLU 1568 CYS 1569 0.0231

CYS 1569 GLY 1570 0.0228

GLY 1570 SER 1571 0.0224

SER 1571 TYR 1572 0.0022

TYR 1572 ASP 1573 0.0202

ASP 1573 LEU 1574 0.0021

LEU 1574 VAL 1575 0.0196

VAL 1575 ILE 1576 0.0011

ILE 1576 ALA 1577 0.0170

ALA 1577 SER 1578 0.0005

SER 1578 GLN 1579 0.0168

GLN 1579 VAL 1580 0.0102

VAL 1580 LEU 1581 0.2353

LEU 1581 HIS 1582 0.0490

HIS 1582 ALA 1583 0.0631

ALA 1583 THR 1584 0.0047

THR 1584 GLY 1585 0.0478

GLY 1585 LYS 1586 0.0524

LYS 1586 MET 1587 0.0577

MET 1587 GLU 1588 0.0208

GLU 1588 HIS 1589 0.0510

HIS 1589 THR 1590 0.0318

THR 1590 MET 1591 0.0654

MET 1591 ALA 1592 0.0007

ALA 1592 ASN 1593 0.0652

ASN 1593 VAL 1594 0.0292

VAL 1594 ARG 1595 0.0448

ARG 1595 LYS 1596 0.0331

LYS 1596 LEU 1597 -0.1651

LEU 1597 LEU 1598 0.0543

LEU 1598 LYS 1599 0.0242

LYS 1599 PRO 1600 0.0499

PRO 1600 GLY 1601 0.0272

GLY 1601 GLY 1602 0.0335

GLY 1602 LYS 1603 0.0034

LYS 1603 LEU 1604 0.0359

LEU 1604 LEU 1605 0.0025

LEU 1605 LEU 1606 0.0372

LEU 1606 VAL 1607 0.0012

VAL 1607 GLU 1608 0.0522

GLU 1608 THR 1609 0.0256

THR 1609 THR 1610 0.0507

THR 1610 ARG 1611 0.0135

ARG 1611 ASP 1612 0.0401

ASP 1612 GLU 1613 -0.1202

GLU 1613 MET 1614 0.1659

MET 1614 ASP 1615 0.2290

ASP 1615 LEU 1616 0.0168

LEU 1616 GLN 1617 0.2280

GLN 1617 LEU 1618 0.1075

LEU 1618 VAL 1619 0.2253

VAL 1619 PHE 1620 0.0073

PHE 1620 GLY 1621 0.2363

GLY 1621 LEU 1622 0.2244

LEU 1622 LEU 1623 0.0571

LEU 1623 PRO 1624 0.0957

PRO 1624 GLY 1625 0.1791

GLY 1625 TRP 1626 0.1752

TRP 1626 TRP 1627 0.2175

TRP 1627 LEU 1628 0.0125

LEU 1628 SER 1629 -0.0970

SER 1629 SER 1630 0.1101

SER 1630 GLU 1631 0.1487

GLU 1631 GLU 1632 0.1025

GLU 1632 GLU 1633 0.1109

GLU 1633 ARG 1634 0.1513

ARG 1634 GLN 1635 0.1475

GLN 1635 MET 1636 0.0062

MET 1636 SER 1637 0.1528

SER 1637 PRO 1638 0.0843

PRO 1638 SER 1639 0.1476

SER 1639 LEU 1640 0.1309

LEU 1640 SER 1641 0.1245

SER 1641 THR 1642 0.1419

THR 1642 ASN 1643 0.1312

ASN 1643 SER 1644 0.1156

SER 1644 TRP 1645 0.2326

TRP 1645 GLU 1646 0.0679

GLU 1646 LYS 1647 0.0546

LYS 1647 VAL 1648 0.0755

VAL 1648 LEU 1649 0.0771

LEU 1649 LYS 1650 0.0546

LYS 1650 LYS 1651 0.0634

LYS 1651 THR 1652 0.0789

THR 1652 GLY 1653 0.0655

GLY 1653 PHE 1654 0.0333

PHE 1654 ASP 1655 0.0782

ASP 1655 GLY 1656 0.0142

GLY 1656 LEU 1657 0.0179

LEU 1657 ASP 1658 0.0806

ASP 1658 ILE 1659 0.0062

ILE 1659 GLU 1660 0.0339

GLU 1660 LEU 1661 0.1210

LEU 1661 ARG 1662 0.0183

ARG 1662 ASP 1663 0.0359

ASP 1663 CYS 1664 0.0701

CYS 1664 ASP 1665 0.0850

ASP 1665 SER 1666 0.0608

SER 1666 ASP 1667 0.0789

ASP 1667 GLU 1668 0.0222

GLU 1668 PHE 1669 0.0872

PHE 1669 TYR 1670 0.0166

TYR 1670 SER 1671 0.0829

SER 1671 PHE 1672 0.0420

PHE 1672 SER 1673 0.0182

SER 1673 VAL 1674 0.0591

VAL 1674 MET 1675 0.0180

MET 1675 MET 1676 0.0159

MET 1676 ALA 1677 -0.0082

ALA 1677 THR 1678 0.0236

THR 1678 ALA 1679 0.0072

ALA 1679 SER 1680 0.0418

SER 1680 SER 1681 0.0406

SER 1681 THR 1682 0.0234

THR 1682 ILE 1683 0.0552

ILE 1683 ALA 1684 0.0101

ALA 1684 SER 1685 0.0568

SER 1685 SER 1686 0.0562

SER 1686 SER 1687 0.0453

SER 1687 MET 1688 0.0375

MET 1688 ALA 1689 0.0545

ALA 1689 PHE 1690 0.0043

PHE 1690 ALA 1691 0.0422

ALA 1691 ILE 1692 0.0044

ILE 1692 VAL 1693 -0.2322

VAL 1693 TYR 1694 0.0221

TYR 1694 GLY 1695 0.0499

GLY 1695 GLU 1696 0.0691

GLU 1696 VAL 1697 0.0745

VAL 1697 PRO 1698 0.0389

PRO 1698 LEU 1699 0.0807

LEU 1699 PRO 1700 0.0802

PRO 1700 ASP 1701 0.0186

ASP 1701 GLN 1702 0.0785

GLN 1702 PHE 1703 0.0777

PHE 1703 LEU 1704 0.0268

LEU 1704 ASP 1705 0.0541

ASP 1705 ASP 1706 0.0677

ASP 1706 MET 1707 0.0798

MET 1707 LYS 1708 0.0071

LYS 1708 THR 1709 0.0251

THR 1709 ALA 1710 0.0643

ALA 1710 ILE 1711 0.0588

ILE 1711 SER 1712 0.0213

SER 1712 SER 1713 0.0769

SER 1713 SER 1714 0.0776

SER 1714 ALA 1715 0.0452

ALA 1715 VAL 1716 0.0102

VAL 1716 SER 1717 0.0742

SER 1717 ASP 1718 0.0504

ASP 1718 PRO 1719 0.0420

PRO 1719 VAL 1720 0.0780

VAL 1720 VAL 1721 0.0140

VAL 1721 GLY 1722 0.0706

GLY 1722 HIS 1723 0.0337

HIS 1723 LEU 1724 0.0771

LEU 1724 ASP 1725 -0.0621

ASP 1725 SER 1726 0.0194

SER 1726 ILE 1727 0.0550

ILE 1727 ASP 1728 0.0226

ASP 1728 ALA 1729 0.0538

ALA 1729 THR 1730 0.0176

THR 1730 GLY 1731 0.0540

GLY 1731 LYS 1732 0.0352

LYS 1732 PHE 1733 0.0256

PHE 1733 CYS 1734 0.0237

CYS 1734 ILE 1735 0.0158

ILE 1735 PHE 1736 0.0364

PHE 1736 ILE 1737 0.0241

ILE 1737 GLU 1738 0.0303

GLU 1738 ASP 1739 0.0319

ASP 1739 PRO 1740 0.0146

PRO 1740 GLU 1741 0.0403

GLU 1741 THR 1742 0.0324

THR 1742 ASP 1743 0.0503

ASP 1743 ILE 1744 0.0160

ILE 1744 LEU 1745 0.0502

LEU 1745 SER 1746 0.0035

SER 1746 SER 1747 0.0495

SER 1747 PRO 1748 0.0036

PRO 1748 ASP 1749 0.0450

ASP 1749 GLU 1750 0.0153

GLU 1750 LYS 1751 0.0358

LYS 1751 SER 1752 0.0448

SER 1752 TYR 1753 0.0498

TYR 1753 ALA 1754 0.0051

ALA 1754 SER 1755 0.0483

SER 1755 ILE 1756 0.0439

ILE 1756 GLN 1757 0.1038

GLN 1757 LYS 1758 0.0225

LYS 1758 LEU 1759 0.0521

LEU 1759 VAL 1760 0.0558

VAL 1760 THR 1761 0.0194

THR 1761 ARG 1762 0.0372

ARG 1762 CYS 1763 0.0516

CYS 1763 LYS 1764 0.0449

LYS 1764 GLY 1765 0.0106

GLY 1765 LEU 1766 0.0085

LEU 1766 ILE 1767 0.0217

ILE 1767 TRP 1768 0.0229

TRP 1768 VAL 1769 0.0282

VAL 1769 SER 1770 0.0044

SER 1770 ARG 1771 0.0079

ARG 1771 GLY 1772 0.0248

GLY 1772 GLY 1773 0.0359

GLY 1773 ALA 1774 0.0588

ALA 1774 MET 1775 0.0370

MET 1775 HIS 1776 0.0108

HIS 1776 GLY 1777 0.0575

GLY 1777 THR 1778 0.0408

THR 1778 ARG 1779 0.0420

ARG 1779 PRO 1780 0.0563

PRO 1780 ASN 1781 0.0383

ASN 1781 SER 1782 0.0452

SER 1782 SER 1783 0.0580

SER 1783 LEU 1784 0.0452

LEU 1784 LYS 1785 0.0247

LYS 1785 THR 1786 0.0611

THR 1786 GLY 1787 0.0612

GLY 1787 LEU 1788 0.0276

LEU 1788 LEU 1789 0.0318

LEU 1789 ARG 1790 0.0461

ARG 1790 THR 1791 0.0386

THR 1791 LEU 1792 0.0238

LEU 1792 ARG 1793 0.0436

ARG 1793 LEU 1794 0.0452

LEU 1794 GLU 1795 0.0382

GLU 1795 TYR 1796 0.0317

TYR 1796 THR 1797 0.0455

THR 1797 GLU 1798 0.0256

GLU 1798 LYS 1799 0.0274

LYS 1799 ARG 1800 0.0261

ARG 1800 PHE 1801 0.0094

PHE 1801 ILE 1802 0.0244

ILE 1802 SER 1803 0.0027

SER 1803 LEU 1804 0.0379

LEU 1804 ASP 1805 0.0150

ASP 1805 LEU 1806 0.0618

LEU 1806 ASP 1807 0.0089

ASP 1807 SER 1808 0.0427

SER 1808 ALA 1809 0.0397

ALA 1809 ARG 1810 0.0421

ARG 1810 PRO 1811 0.0638

PRO 1811 GLN 1812 0.0356

GLN 1812 TRP 1813 0.0300

TRP 1813 ASN 1814 0.0684

ASN 1814 HIS 1815 0.0392

HIS 1815 ASP 1816 0.0618

ASP 1816 SER 1817 0.0639

SER 1817 ILE 1818 0.0123

ILE 1818 THR 1819 0.0684

THR 1819 THR 1820 0.0639

THR 1820 ILE 1821 0.0974

ILE 1821 ASN 1822 0.0206

ASN 1822 GLU 1823 0.0364

GLU 1823 VAL 1824 0.0428

VAL 1824 LEU 1825 0.0060

LEU 1825 CYS 1826 0.0388

CYS 1826 GLY 1827 0.0349

GLY 1827 ALA 1828 0.0334

ALA 1828 LEU 1829 0.0103

LEU 1829 ALA 1830 0.0426

ALA 1830 GLN 1831 0.0425

GLN 1831 ASN 1832 0.0112

ASN 1832 ALA 1833 0.0414

ALA 1833 ASP 1834 0.0292

ASP 1834 SER 1835 0.0034

SER 1835 SER 1836 0.0404

SER 1836 ILE 1837 0.0206

ILE 1837 LYS 1838 0.0397

LYS 1838 ASP 1839 0.0045

ASP 1839 SER 1840 0.0414

SER 1840 GLU 1841 -0.0000

GLU 1841 PHE 1842 0.0304

PHE 1842 ALA 1843 0.0026

ALA 1843 GLU 1844 0.0345

GLU 1844 GLN 1845 0.0084

GLN 1845 ASP 1846 0.0338

ASP 1846 GLY 1847 0.0105

GLY 1847 GLN 1848 0.0320

GLN 1848 LEU 1849 0.0205

LEU 1849 PHE 1850 0.0420

PHE 1850 VAL 1851 0.0250

VAL 1851 PRO 1852 0.0410

PRO 1852 ARG 1853 0.1016

ARG 1853 ILE 1854 0.0259

ILE 1854 SER 1855 0.0236

SER 1855 CYS 1856 0.0326

CYS 1856 ASP 1857 0.0275

ASP 1857 ILE 1858 0.0263

ILE 1858 ALA 1859 0.0253

ALA 1859 ARG 1860 0.0100

ARG 1860 ASN 1861 0.0246

ASN 1861 GLU 1862 0.0161

GLU 1862 ASP 1863 0.0329

ASP 1863 LEU 1864 0.0002

LEU 1864 SER 1865 0.0329

SER 1865 SER 1866 0.0140

SER 1866 ASP 1867 0.0206

ASP 1867 SER 1868 0.0324

SER 1868 ASN 1869 0.1132

ASN 1869 SER 1870 0.0096

SER 1870 PRO 1871 0.0414

PRO 1871 ALA 1872 0.0420

ALA 1872 GLN 1873 0.0041

GLN 1873 MET 1874 0.0405

MET 1874 GLU 1875 0.0350

GLU 1875 PRO 1876 0.0407

PRO 1876 PHE 1877 0.0173

PHE 1877 HIS 1878 0.0263

HIS 1878 GLN 1879 0.0340

GLN 1879 PRO 1880 0.0344

PRO 1880 GLY 1881 0.0351

GLY 1881 LYS 1882 0.0249

LYS 1882 LEU 1883 0.0023

LEU 1883 LEU 1884 0.0340

LEU 1884 GLN 1885 -0.0250

GLN 1885 MET 1886 0.0242

MET 1886 GLY 1887 0.0068

GLY 1887 ILE 1888 0.0215

ILE 1888 LYS 1889 0.0287

LYS 1889 THR 1890 0.0099

THR 1890 PRO 1891 0.0217

PRO 1891 GLY 1892 0.0285

GLY 1892 LEU 1893 0.0063

LEU 1893 ILE 1894 0.0151

ILE 1894 ASP 1895 0.0152

ASP 1895 THR 1896 0.0282

THR 1896 LEU 1897 0.0244

LEU 1897 GLN 1898 0.0176

GLN 1898 PHE 1899 0.0231

PHE 1899 SER 1900 0.0288

SER 1900 LYS 1901 0.0811

LYS 1901 THR 1902 0.0476

THR 1902 ASP 1903 0.0511

ASP 1903 ALA 1904 0.0585

ALA 1904 THR 1905 0.0530

THR 1905 ASP 1906 0.0419

ASP 1906 ASN 1907 0.0272

ASN 1907 LEU 1908 0.0408

LEU 1908 PRO 1909 0.0168

PRO 1909 ASN 1910 0.0581

ASN 1910 ASP 1911 0.0291

ASP 1911 TYR 1912 0.0484

TYR 1912 ILE 1913 0.0402

ILE 1913 GLU 1914 0.0338

GLU 1914 ILE 1915 0.0595

ILE 1915 GLU 1916 0.0345

GLU 1916 PRO 1917 -0.0274

PRO 1917 LYS 1918 0.0196

LYS 1918 ALA 1919 0.0181

ALA 1919 PHE 1920 0.0098

PHE 1920 GLY 1921 0.0134

GLY 1921 LEU 1922 0.0282

LEU 1922 ASN 1923 0.0018

ASN 1923 PHE 1924 0.0216

PHE 1924 ARG 1925 0.0253

ARG 1925 ASP 1926 0.0050

ASP 1926 VAL 1927 0.0289

VAL 1927 MET 1928 0.0050

MET 1928 VAL 1929 0.0270

VAL 1929 ALA 1930 0.0071

ALA 1930 MET 1931 0.0212

MET 1931 GLY 1932 0.0170

GLY 1932 GLN 1933 -0.1223

GLN 1933 LEU 1934 0.0317

LEU 1934 GLU 1935 0.0336

GLU 1935 GLU 1936 0.0292

GLU 1936 SER 1937 0.0015

SER 1937 ILE 1938 0.0356

ILE 1938 MET 1939 0.0221

MET 1939 GLY 1940 0.0324

GLY 1940 PHE 1941 0.0186

PHE 1941 GLU 1942 0.0289

GLU 1942 CYS 1943 0.0100

CYS 1943 ALA 1944 0.0294

ALA 1944 GLY 1945 0.0227

GLY 1945 VAL 1946 0.0348

VAL 1946 VAL 1947 0.0278

VAL 1947 ARG 1948 0.0253

ARG 1948 ARG 1949 0.0840

ARG 1949 VAL 1950 0.0200

VAL 1950 GLY 1951 0.0419

GLY 1951 PRO 1952 0.0547

PRO 1952 SER 1953 0.0046

SER 1953 SER 1954 0.0539

SER 1954 ALA 1955 0.0308

ALA 1955 GLY 1956 0.0254

GLY 1956 HIS 1957 0.0457

HIS 1957 ASN 1958 0.0312

ASN 1958 ILE 1959 0.0428

ILE 1959 LYS 1960 0.0010

LYS 1960 VAL 1961 0.0240

VAL 1961 GLY 1962 0.0493

GLY 1962 ASP 1963 0.0117

ASP 1963 ARG 1964 0.0524

ARG 1964 VAL 1965 0.0127

VAL 1965 CYS 1966 0.0273

CYS 1966 ALA 1967 0.0339

ALA 1967 LEU 1968 0.0181

LEU 1968 LEU 1969 0.0464

LEU 1969 GLY 1970 0.0391

GLY 1970 GLY 1971 0.0450

GLY 1971 GLN 1972 0.0035

GLN 1972 TRP 1973 0.0260

TRP 1973 THR 1974 0.0206

THR 1974 ASN 1975 0.0099

ASN 1975 THR 1976 0.0458

THR 1976 VAL 1977 0.0048

VAL 1977 ARG 1978 0.0387

ARG 1978 VAL 1979 0.0137

VAL 1979 HIS 1980 0.0321

HIS 1980 TRP 1981 0.0772

TRP 1981 HIS 1982 0.0132

HIS 1982 SER 1983 0.0448

SER 1983 VAL 1984 0.0221

VAL 1984 ALA 1985 0.0526

ALA 1985 PRO 1986 0.0219

PRO 1986 ILE 1987 0.0464

ILE 1987 PRO 1988 0.0483

PRO 1988 GLN 1989 0.0013

GLN 1989 ALA 1990 0.0524

ALA 1990 MET 1991 0.0423

MET 1991 ASP 1992 0.0361

ASP 1992 TRP 1993 0.0519

TRP 1993 GLU 1994 0.0477

GLU 1994 THR 1995 0.0255

THR 1995 ALA 1996 0.0507

ALA 1996 ALA 1997 -0.0049

ALA 1997 SER 1998 0.0215

SER 1998 ILE 1999 0.0068

ILE 1999 PRO 2000 0.0234

PRO 2000 ILE 2001 0.0249

ILE 2001 VAL 2002 0.0260

VAL 2002 PHE 2003 0.0191

PHE 2003 VAL 2004 0.0227

VAL 2004 THR 2005 0.0256

THR 2005 ALA 2006 0.0234

ALA 2006 TYR 2007 0.0219

TYR 2007 ILE 2008 0.0223

ILE 2008 SER 2009 0.0253

SER 2009 LEU 2010 0.0240

LEU 2010 VAL 2011 0.0258

VAL 2011 LYS 2012 0.0254

LYS 2012 ILE 2013 0.1413

ILE 2013 ALA 2014 0.0080

ALA 2014 ARG 2015 0.0068

ARG 2015 MET 2016 0.0093

MET 2016 GLN 2017 0.0048

GLN 2017 ALA 2018 0.0093

ALA 2018 GLY 2019 0.0089

GLY 2019 GLU 2020 0.0083

GLU 2020 THR 2021 0.0054

THR 2021 VAL 2022 0.0022

VAL 2022 LEU 2023 0.0042

LEU 2023 ILE 2024 0.0016

ILE 2024 HIS 2025 0.0041

HIS 2025 ALA 2026 0.0008

ALA 2026 ALA 2027 0.0078

ALA 2027 SER 2028 0.0020

SER 2028 GLY 2029 0.0655

GLY 2029 GLY 2030 0.0214

GLY 2030 VAL 2031 0.0044

VAL 2031 GLY 2032 0.0179

GLY 2032 GLN 2033 0.0190

GLN 2033 ALA 2034 0.0193

ALA 2034 ALA 2035 0.0046

ALA 2035 ILE 2036 0.0213

ILE 2036 ILE 2037 0.0203

ILE 2037 LEU 2038 0.0110

LEU 2038 ALA 2039 0.0123

ALA 2039 LYS 2040 0.0209

LYS 2040 HIS 2041 0.0210

HIS 2041 VAL 2042 0.0047

VAL 2042 GLY 2043 0.0196

GLY 2043 ALA 2044 0.0211

ALA 2044 GLU 2045 -0.0887

GLU 2045 ILE 2046 0.0052

ILE 2046 PHE 2047 0.0133

PHE 2047 ALA 2048 0.0020

ALA 2048 THR 2049 0.0099

THR 2049 VAL 2050 0.0015

VAL 2050 GLY 2051 0.0084

GLY 2051 THR 2052 0.0111

THR 2052 ASP 2053 0.0130

ASP 2053 GLU 2054 0.0064

GLU 2054 LYS 2055 0.0104

LYS 2055 ARG 2056 0.0038

ARG 2056 ASP 2057 0.0110

ASP 2057 LEU 2058 0.0122

LEU 2058 LEU 2059 0.0017

LEU 2059 ILE 2060 0.0119

ILE 2060 LYS 2061 0.0237

LYS 2061 GLU 2062 0.0103

GLU 2062 TYR 2063 0.0046

TYR 2063 LYS 2064 0.0053

LYS 2064 ILE 2065 0.0099

ILE 2065 PRO 2066 0.0074

PRO 2066 ASP 2067 0.0089

ASP 2067 ASP 2068 0.0043

ASP 2068 HIS 2069 0.0105

HIS 2069 ILE 2070 0.0017

ILE 2070 PHE 2071 0.0107

PHE 2071 SER 2072 0.0046

SER 2072 SER 2073 0.0097

SER 2073 ARG 2074 0.0094

ARG 2074 ASN 2075 0.0028

ASN 2075 ALA 2076 0.0027

ALA 2076 LEU 2077 0.0710

LEU 2077 PHE 2078 0.0079

PHE 2078 ALA 2079 0.0073

ALA 2079 LYS 2080 0.0085

LYS 2080 SER 2081 0.0099

SER 2081 ILE 2082 0.0081

ILE 2082 ARG 2083 0.0066

ARG 2083 GLN 2084 0.0094

GLN 2084 ARG 2085 0.0097

ARG 2085 THR 2086 0.0074

THR 2086 ASN 2087 0.0074

ASN 2087 GLY 2088 0.0077

GLY 2088 LYS 2089 0.0095

LYS 2089 GLY 2090 0.0016

GLY 2090 VAL 2091 0.0099

VAL 2091 ASP 2092 0.0083

ASP 2092 VAL 2093 0.0034

VAL 2093 VAL 2094 -0.0000

VAL 2094 LEU 2095 0.0045

LEU 2095 ASN 2096 0.0022

ASN 2096 CYS 2097 0.0009

CYS 2097 LEU 2098 0.0059

LEU 2098 ALA 2099 0.0060

ALA 2099 GLY 2100 0.0076

GLY 2100 GLY 2101 0.0062

GLY 2101 LEU 2102 0.0068

LEU 2102 LEU 2103 0.0050

LEU 2103 GLN 2104 0.0064

GLN 2104 GLU 2105 0.0074

GLU 2105 SER 2106 0.0062

SER 2106 PHE 2107 0.0052

PHE 2107 ASP 2108 0.0069

ASP 2108 CYS 2109 -0.0377

CYS 2109 LEU 2110 0.0051

LEU 2110 ALA 2111 0.0005

ALA 2111 ASP 2112 0.0051

ASP 2112 PHE 2113 0.0088

PHE 2113 GLY 2114 0.0033

GLY 2114 ARG 2115 0.0066

ARG 2115 PHE 2116 -0.0001

PHE 2116 ILE 2117 0.0069

ILE 2117 GLU 2118 0.0006

GLU 2118 ILE 2119 0.0066

ILE 2119 GLY 2120 0.0019

GLY 2120 LYS 2121 0.0070

LYS 2121 ARG 2122 0.0046

ARG 2122 ASP 2123 0.0066

ASP 2123 ILE 2124 0.0070

ILE 2124 GLU 2125 0.0690

GLU 2125 LEU 2126 0.0005

LEU 2126 ASN 2127 0.0024

ASN 2127 HIS 2128 0.0022

HIS 2128 CYS 2129 0.0025

CYS 2129 LEU 2130 0.0015

LEU 2130 ASN 2131 0.0026

ASN 2131 MET 2132 0.0015

MET 2132 GLY 2133 0.0026

GLY 2133 MET 2134 0.0011

MET 2134 PHE 2135 0.0018

PHE 2135 ALA 2136 0.0026

ALA 2136 ARG 2137 0.0018

ARG 2137 SER 2138 0.0012

SER 2138 ALA 2139 0.0023

ALA 2139 THR 2140 0.0022

THR 2140 PHE 2141 0.0994

PHE 2141 THR 2142 0.0268

THR 2142 ALA 2143 0.0146

ALA 2143 VAL 2144 0.0237

VAL 2144 ASP 2145 0.0232

ASP 2145 LEU 2146 0.0258

LEU 2146 ILE 2147 0.0292

ILE 2147 ALA 2148 0.0020

ALA 2148 ILE 2149 0.0280

ILE 2149 GLY 2150 0.0190

GLY 2150 ARG 2151 0.0243

ARG 2151 ASP 2152 0.0022

ASP 2152 ARG 2153 0.0295

ARG 2153 SER 2154 0.0130

SER 2154 TYR 2155 0.0218

TYR 2155 MET 2156 0.0275

MET 2156 PHE 2157 0.0555

PHE 2157 ALA 2158 0.0354

ALA 2158 GLU 2159 0.0211

GLU 2159 ALA 2160 0.0324

ALA 2160 LEU 2161 0.0000

LEU 2161 PRO 2162 0.0351

PRO 2162 LYS 2163 0.0204

LYS 2163 ILE 2164 0.0269

ILE 2164 MET 2165 0.0107

MET 2165 THR 2166 0.0289

THR 2166 LEU 2167 0.0321

LEU 2167 LEU 2168 0.0057

LEU 2168 GLN 2169 0.0298

GLN 2169 GLU 2170 0.0208

GLU 2170 LYS 2171 0.0337

LYS 2171 ALA 2172 0.0017

ALA 2172 ILE 2173 0.0561

ILE 2173 ARG 2174 0.0161

ARG 2174 PRO 2175 0.0283

PRO 2175 VAL 2176 0.0268

VAL 2176 THR 2177 0.0218

THR 2177 PRO 2178 0.0199

PRO 2178 ILE 2179 0.0264

ILE 2179 SER 2180 0.0267

SER 2180 ILE 2181 0.0137

ILE 2181 TYR 2182 0.0283

TYR 2182 LYS 2183 0.0183

LYS 2183 ILE 2184 0.0253

ILE 2184 GLY 2185 0.0220

GLY 2185 ASP 2186 0.0223

ASP 2186 ILE 2187 0.0062

ILE 2187 GLU 2188 0.0260

GLU 2188 THR 2189 0.1364

THR 2189 ALA 2190 0.0171

ALA 2190 PHE 2191 0.0175

PHE 2191 ARG 2192 0.0287

ARG 2192 LEU 2193 0.0281

LEU 2193 MET 2194 0.0102

MET 2194 GLN 2195 0.0259

GLN 2195 ALA 2196 0.0286

ALA 2196 GLY 2197 0.0191

GLY 2197 LYS 2198 0.0178

LYS 2198 HIS 2199 0.0279

HIS 2199 MET 2200 0.0245

MET 2200 GLY 2201 0.0283

GLY 2201 LYS 2202 0.0231

LYS 2202 ILE 2203 0.0118

ILE 2203 VAL 2204 0.0192

VAL 2204 ILE 2205 0.2564

ILE 2205 THR 2206 0.0044

THR 2206 ALA 2207 0.0184

ALA 2207 PRO 2208 0.0046

PRO 2208 GLU 2209 0.0126

GLU 2209 ASP 2210 0.0286

ASP 2210 ALA 2211 0.0043

ALA 2211 MET 2212 0.0302

MET 2212 VAL 2213 0.0090

VAL 2213 PRO 2214 0.0281

PRO 2214 VAL 2215 0.0297

VAL 2215 ILE 2216 0.0279

ILE 2216 THR 2217 0.0221

THR 2217 ARG 2218 0.0181

ARG 2218 PRO 2219 0.0244

PRO 2219 PRO 2220 0.0301

PRO 2220 LYS 2221 0.9378

LYS 2221 LEU 2222 0.0218

LEU 2222 GLN 2223 0.0130

GLN 2223 LEU 2224 0.0220

LEU 2224 ARG 2225 0.0045

ARG 2225 PRO 2226 0.0316

PRO 2226 ASP 2227 0.0027

ASP 2227 ALA 2228 0.0301

ALA 2228 SER 2229 0.0270

SER 2229 TYR 2230 0.0123

TYR 2230 LEU 2231 0.0316

LEU 2231 ILE 2232 0.0057

ILE 2232 VAL 2233 0.0315

VAL 2233 GLY 2234 0.0093

GLY 2234 GLY 2235 0.0318

GLY 2235 LEU 2236 0.0229

LEU 2236 GLY 2237 -0.0108

GLY 2237 GLY 2238 0.0088

GLY 2238 ILE 2239 0.0228

ILE 2239 GLY 2240 0.0048

GLY 2240 ARG 2241 0.0223

ARG 2241 SER 2242 0.0199

SER 2242 LEU 2243 0.0075

LEU 2243 CYS 2244 0.0199

CYS 2244 LYS 2245 0.0137

LYS 2245 ASN 2246 0.0256

ASN 2246 PHE 2247 0.0001

PHE 2247 VAL 2248 0.0256

VAL 2248 GLU 2249 0.0128

GLU 2249 ASN 2250 0.0193

ASN 2250 GLY 2251 0.0072

GLY 2251 ALA 2252 0.0212

ALA 2252 ARG 2253 0.0242

ARG 2253 SER 2254 0.0315

SER 2254 LEU 2255 0.0245

LEU 2255 VAL 2256 0.0336

VAL 2256 LEU 2257 0.0184

LEU 2257 LEU 2258 0.0354

LEU 2258 SER 2259 0.0262

SER 2259 ARG 2260 0.0354

ARG 2260 ASN 2261 0.0346

ASN 2261 ALA 2262 0.0300

ALA 2262 ASN 2263 0.0358

ASN 2263 VAL 2264 0.0025

VAL 2264 SER 2265 0.0323

SER 2265 GLN 2266 0.0211

GLN 2266 GLN 2267 0.0124

GLN 2267 SER 2268 0.0302

SER 2268 GLY 2269 -0.1141

GLY 2269 GLU 2270 0.0109

GLU 2270 PHE 2271 0.0328

PHE 2271 LEU 2272 0.0029

LEU 2272 ASP 2273 0.0334

ASP 2273 GLU 2274 0.0096

GLU 2274 LEU 2275 0.0261

LEU 2275 ARG 2276 0.0122

ARG 2276 SER 2277 0.0223

SER 2277 THR 2278 0.0316

THR 2278 GLY 2279 0.0026

GLY 2279 CYS 2280 0.0331

CYS 2280 ILE 2281 0.0076

ILE 2281 VAL 2282 0.0313

VAL 2282 GLY 2283 0.0157

GLY 2283 VAL 2284 0.0308

VAL 2284 VAL 2285 0.2688

VAL 2285 ASP 2286 0.0329

ASP 2286 CYS 2287 0.0431

CYS 2287 ASP 2288 0.0275

ASP 2288 ILE 2289 0.0409

ILE 2289 SER 2290 0.0378

SER 2290 SER 2291 0.0174

SER 2291 LYS 2292 0.0149

LYS 2292 THR 2293 0.0287

THR 2293 GLN 2294 0.0356

GLN 2294 VAL 2295 0.0430

VAL 2295 GLU 2296 0.0033

GLU 2296 ALA 2297 0.0419

ALA 2297 THR 2298 0.0320

THR 2298 MET 2299 0.0334

MET 2299 LEU 2300 0.0103

LEU 2300 ARG 2301 0.0935

ARG 2301 LEU 2302 0.0350

LEU 2302 LYS 2303 0.0089

LYS 2303 LYS 2304 0.0336

LYS 2304 ASP 2305 0.0196

ASP 2305 MET 2306 0.0332

MET 2306 LEU 2307 0.0366

LEU 2307 PRO 2308 0.0389

PRO 2308 ILE 2309 0.0097

ILE 2309 ARG 2310 0.0376

ARG 2310 GLY 2311 0.0025

GLY 2311 ILE 2312 0.0210

ILE 2312 VAL 2313 0.0001

VAL 2313 HIS 2314 0.0331

HIS 2314 ALA 2315 0.0064

ALA 2315 GLY 2316 0.0392

GLY 2316 MET 2317 -0.1375

MET 2317 VAL 2318 0.0218

VAL 2318 LEU 2319 0.0052

LEU 2319 GLN 2320 0.0242

GLN 2320 ASP 2321 0.0191

ASP 2321 SER 2322 0.0219

SER 2322 VAL 2323 0.0336

VAL 2323 PHE 2324 0.0449

PHE 2324 GLU 2325 0.0188

GLU 2325 ARG 2326 0.0507

ARG 2326 MET 2327 -0.0000

MET 2327 SER 2328 0.0458

SER 2328 LEU 2329 0.0191

LEU 2329 ASP 2330 0.0408

ASP 2330 ASP 2331 0.0482

ASP 2331 TYR 2332 0.0472

TYR 2332 ASN 2333 -0.0665

ASN 2333 THR 2334 0.0489

THR 2334 ALA 2335 0.0484

ALA 2335 ILE 2336 0.0320

ILE 2336 ARG 2337 0.0204

ARG 2337 PRO 2338 0.0417

PRO 2338 LYS 2339 0.0488

LYS 2339 VAL 2340 0.0464

VAL 2340 GLN 2341 0.0321

GLN 2341 GLY 2342 0.0440

GLY 2342 SER 2343 0.0457

SER 2343 TRP 2344 0.0401

TRP 2344 ASN 2345 0.0375

ASN 2345 LEU 2346 0.0445

LEU 2346 HIS 2347 0.0459

HIS 2347 SER 2348 0.0365

SER 2348 GLY 2349 0.1130

GLY 2349 LEU 2350 0.0378

LEU 2350 SER 2351 0.0319

SER 2351 ASP 2352 0.0128

ASP 2352 CYS 2353 0.0390

CYS 2353 ASP 2354 0.0402

ASP 2354 LEU 2355 0.0089

LEU 2355 ASP 2356 0.0420

ASP 2356 PHE 2357 0.0031

PHE 2357 PHE 2358 0.0253

PHE 2358 ILE 2359 0.0038

ILE 2359 MET 2360 0.0157

MET 2360 LEU 2361 0.0099

LEU 2361 SER 2362 0.0301

SER 2362 SER 2363 0.0033

SER 2363 LEU 2364 0.0303

LEU 2364 ALA 2365 0.1489

ALA 2365 GLY 2366 0.0412

GLY 2366 VAL 2367 0.0571

VAL 2367 SER 2368 0.0098

SER 2368 GLY 2369 0.0471

GLY 2369 SER 2370 0.0439

SER 2370 ALA 2371 0.0143

ALA 2371 SER 2372 0.0572

SER 2372 GLN 2373 0.0005

GLN 2373 ALA 2374 0.0566

ALA 2374 ASN 2375 0.0285

ASN 2375 TYR 2376 0.0448

TYR 2376 THR 2377 0.0572

THR 2377 ALA 2378 0.0498

ALA 2378 GLY 2379 0.0256

GLY 2379 GLY 2380 0.0559

GLY 2380 ALA 2381 0.0456

ALA 2381 TYR 2382 0.0263

TYR 2382 GLN 2383 0.0378

GLN 2383 ASP 2384 0.0516

ASP 2384 ALA 2385 0.0461

ALA 2385 LEU 2386 0.0267

LEU 2386 ALA 2387 0.0473

ALA 2387 LYS 2388 0.0515

LYS 2388 TYR 2389 0.0418

TYR 2389 ARG 2390 0.0296

ARG 2390 ARG 2391 0.0502

ARG 2391 ALA 2392 0.0511

ALA 2392 GLN 2393 0.0284

GLN 2393 GLY 2394 0.0412

GLY 2394 LEU 2395 0.0470

LEU 2395 SER 2396 0.0425

SER 2396 ALA 2397 -0.0533

ALA 2397 VAL 2398 0.0080

VAL 2398 SER 2399 0.0036

SER 2399 ILE 2400 0.0168

ILE 2400 ASP 2401 0.0031

ASP 2401 LEU 2402 0.0252

LEU 2402 GLY 2403 0.0040

GLY 2403 MET 2404 0.0201

MET 2404 VAL 2405 0.0200

VAL 2405 GLN 2406 0.0179

GLN 2406 SER 2407 0.0201

SER 2407 VAL 2408 0.0198

VAL 2408 GLY 2409 0.0275

GLY 2409 TYR 2410 0.0122

TYR 2410 VAL 2411 0.0158

VAL 2411 ALA 2412 0.0270

ALA 2412 GLU 2413 0.1286

GLU 2413 THR 2414 0.0103

THR 2414 LYS 2415 0.0142

LYS 2415 GLY 2416 0.0301

GLY 2416 VAL 2417 0.0238

VAL 2417 ALA 2418 0.0364

ALA 2418 GLU 2419 0.0082

GLU 2419 ARG 2420 0.0395

ARG 2420 LEU 2421 0.0123

LEU 2421 VAL 2422 0.0411

VAL 2422 ARG 2423 0.0067

ARG 2423 MET 2424 0.0350

MET 2424 GLY 2425 0.0270

GLY 2425 TYR 2426 0.0136

TYR 2426 SER 2427 0.0297

SER 2427 PRO 2428 0.0358

PRO 2428 ILE 2429 0.1031

ILE 2429 SER 2430 0.0391

SER 2430 GLU 2431 0.0167

GLU 2431 MET 2432 0.0341

MET 2432 GLU 2433 0.0404

GLU 2433 VAL 2434 0.0333

VAL 2434 LEU 2435 0.0184

LEU 2435 LYS 2436 0.0400

LYS 2436 ILE 2437 0.0405

ILE 2437 VAL 2438 0.0217

VAL 2438 GLU 2439 0.0304

GLU 2439 HIS 2440 0.0403

HIS 2440 ALA 2441 0.0372

ALA 2441 ILE 2442 0.0153

ILE 2442 THR 2443 0.0388

THR 2443 ASN 2444 0.0382

ASN 2444 PRO 2445 0.1041

PRO 2445 PRO 2446 0.0286

PRO 2446 PRO 2447 0.0117

PRO 2447 GLU 2448 0.0269

GLU 2448 ALA 2449 0.0255

ALA 2449 SER 2450 0.0113

SER 2450 SER 2451 0.0313

SER 2451 ALA 2452 0.0315

ALA 2452 GLN 2453 0.0006

GLN 2453 ILE 2454 0.0257

ILE 2454 ILE 2455 0.0008

ILE 2455 THR 2456 0.0230

THR 2456 GLY 2457 0.0040

GLY 2457 ILE 2458 0.0262

ILE 2458 SER 2459 0.0201

SER 2459 THR 2460 0.0302

THR 2460 LYS 2461 0.0528

LYS 2461 PRO 2462 0.0090

PRO 2462 GLY 2463 0.0055

GLY 2463 ARG 2464 0.0031

ARG 2464 HIS 2465 0.0180

HIS 2465 TRP 2466 0.0197

TRP 2466 THR 2467 0.0014

THR 2467 GLU 2468 0.0179

GLU 2468 SER 2469 0.0126

SER 2469 SER 2470 0.0197

SER 2470 TRP 2471 0.0044

TRP 2471 LEU 2472 0.0164

LEU 2472 GLN 2473 0.0146

GLN 2473 ASP 2474 0.0164

ASP 2474 ALA 2475 0.0137

ALA 2475 ARG 2476 0.0081

ARG 2476 PHE 2477 0.1384

PHE 2477 ALA 2478 0.0197

ALA 2478 THR 2479 0.0003

THR 2479 LEU 2480 0.0198

LEU 2480 ARG 2481 0.0091

ARG 2481 GLU 2482 0.0161

GLU 2482 ARG 2483 0.0049

ARG 2483 ALA 2484 0.0146

ALA 2484 ARG 2485 0.0171

ARG 2485 ASP 2486 0.0037

ASP 2486 VAL 2487 0.0175

VAL 2487 LYS 2488 0.0083

LYS 2488 GLU 2489 0.0194

GLU 2489 LEU 2490 0.0003

LEU 2490 SER 2491 0.0187

SER 2491 ASN 2492 0.0153

ASN 2492 SER 2493 -0.0160

SER 2493 GLN 2494 0.0053

GLN 2494 ASN 989 -0.1902

ASN 989 LYS 990 0.0601

LYS 990 ALA 991 0.0103

ALA 991 HIS 992 0.0548

HIS 992 ARG 993 0.0265

ARG 993 GLN 994 0.0411

GLN 994 ARG 995 0.0283

ARG 995 VAL 996 0.0521

VAL 996 HIS 997 0.0412

HIS 997 PRO 998 0.0546

PRO 998 PRO 999 0.0431

PRO 999 HIS 1000 0.0206

HIS 1000 ASP 1001 0.0525

ASP 1001 LEU 1002 0.0103

LEU 1002 LEU 1003 0.0587

LEU 1003 GLY 1004 0.0129

GLY 1004 SER 1005 -0.0531

SER 1005 LEU 1006 0.0311

LEU 1006 ILE 1007 0.0375

ILE 1007 VAL 1008 0.0275

VAL 1008 GLY 1009 0.0357

GLY 1009 ARG 1010 0.0017

ARG 1010 ASP 1011 0.0218

ASP 1011 LEU 1012 0.0383

LEU 1012 ARG 1013 0.0026

ARG 1013 GLU 1014 0.0392

GLU 1014 PRO 1015 0.0179

PRO 1015 THR 1016 0.0356

THR 1016 TRP 1017 0.0274

TRP 1017 ARG 1018 0.0273

ARG 1018 HIS 1019 0.0378

HIS 1019 PHE 1020 0.0275

PHE 1020 ILE 1021 0.2546

ILE 1021 ARG 1022 0.0454

ARG 1022 VAL 1023 0.0186

VAL 1023 GLN 1024 0.0290

GLN 1024 ASP 1025 0.0388

ASP 1025 ILE 1026 0.0102

ILE 1026 PRO 1027 0.0245

PRO 1027 TRP 1028 0.0185

TRP 1028 ILE 1029 0.0453

ILE 1029 ARG 1030 0.0375

ARG 1030 ASP 1031 0.0154

ASP 1031 HIS 1032 0.0447

HIS 1032 VAL 1033 0.0396

VAL 1033 VAL 1034 0.0352

VAL 1034 GLN 1035 0.0390

GLN 1035 SER 1036 0.0347

SER 1036 ALA 1037 0.0089

ALA 1037 LEU 1038 0.0187

LEU 1038 VAL 1039 0.0339

VAL 1039 TYR 1040 0.0215

TYR 1040 PRO 1041 0.0216

PRO 1041 GLY 1042 0.0332

GLY 1042 ALA 1043 0.0332

ALA 1043 GLY 1044 0.0052

GLY 1044 PHE 1045 0.0327

PHE 1045 ILE 1046 0.0326

ILE 1046 CYS 1047 0.0242

CYS 1047 MET 1048 0.0149

MET 1048 ALA 1049 0.0341

ALA 1049 MET 1050 0.0341

MET 1050 GLU 1051 0.0135

GLU 1051 ALA 1052 0.0272

ALA 1052 MET 1053 0.1213

MET 1053 VAL 1054 0.0213

VAL 1054 GLN 1055 0.0069

GLN 1055 LEU 1056 0.0257

LEU 1056 HIS 1057 0.0256

HIS 1057 GLU 1058 0.0114

GLU 1058 LEU 1059 0.0177

LEU 1059 ARG 1060 0.0246

ARG 1060 ASP 1061 0.0251

ASP 1061 SER 1062 0.0113

SER 1062 GLN 1063 0.0162

GLN 1063 SER 1064 0.0173

SER 1064 ARG 1065 0.0051

ARG 1065 LYS 1066 0.0153

LYS 1066 VAL 1067 0.0156

VAL 1067 ALA 1068 0.0025

ALA 1068 GLY 1069 0.0711

GLY 1069 TYR 1070 0.0299

TYR 1070 ARG 1071 0.0173

ARG 1071 LEU 1072 0.0284

LEU 1072 ALA 1073 0.0195

ALA 1073 GLU 1074 0.0265

GLU 1074 VAL 1075 0.0282

VAL 1075 ASP 1076 0.0284

ASP 1076 ILE 1077 0.0295

ILE 1077 LEU 1078 0.0296

LEU 1078 ARG 1079 0.0289

ARG 1079 ALA 1080 0.0299

ALA 1080 MET 1081 0.0039

MET 1081 LEU 1082 0.0298

LEU 1082 ILE 1083 0.0162

ILE 1083 PRO 1084 0.0257

PRO 1084 ASP 1085 0.0312

ASP 1085 THR 1086 0.0105

THR 1086 SER 1087 0.0167

SER 1087 GLU 1088 0.0316

GLU 1088 GLY 1089 0.0027

GLY 1089 LEU 1090 0.0172

LEU 1090 GLU 1091 0.0348

GLU 1091 ALA 1092 0.0093

ALA 1092 HIS 1093 0.0321

HIS 1093 ILE 1094 0.0172

ILE 1094 SER 1095 0.0332

SER 1095 LEU 1096 0.0224

LEU 1096 ARG 1097 0.0282

ARG 1097 PRO 1098 0.0235

PRO 1098 CYS 1099 0.0043

CYS 1099 SER 1100 0.0327

SER 1100 THR 1101 -0.1744

THR 1101 LYS 1102 0.0132

LYS 1102 LEU 1103 0.0198

LEU 1103 LEU 1104 0.0090

LEU 1104 LEU 1105 0.0170

LEU 1105 THR 1106 0.0216

THR 1106 ASN 1107 0.0058

ASN 1107 GLU 1108 0.0026

GLU 1108 TRP 1109 0.0217

TRP 1109 TYR 1110 0.0080

TYR 1110 ASP 1111 0.0216

ASP 1111 PHE 1112 0.0125

PHE 1112 CYS 1113 0.0174

CYS 1113 VAL 1114 0.0148

VAL 1114 SER 1115 0.0139

SER 1115 SER 1116 0.0074

SER 1116 VAL 1117 0.0304

VAL 1117 GLY 1118 0.0275

GLY 1118 ASP 1119 0.0100

ASP 1119 ASP 1120 0.0264

ASP 1120 ASP 1121 0.0277

ASP 1121 LYS 1122 0.0007

LYS 1122 PHE 1123 0.0199

PHE 1123 VAL 1124 0.0108

VAL 1124 ASP 1125 0.0148

ASP 1125 HIS 1126 0.0246

HIS 1126 CYS 1127 0.0202

CYS 1127 ARG 1128 0.0241

ARG 1128 GLY 1129 0.0201

GLY 1129 ARG 1130 0.0280

ARG 1130 ILE 1131 0.0240

ILE 1131 THR 1132 0.0278

THR 1132 ILE 1133 0.1244

ILE 1133 GLU 1134 0.0213

GLU 1134 PHE 1135 0.0052

PHE 1135 ASP 1136 0.0204

ASP 1136 THR 1137 0.0164

THR 1137 SER 1138 0.0119

SER 1138 GLY 1139 0.0230

GLY 1139 SER 1140 0.0026

SER 1140 ALA 1141 0.0212

ALA 1141 ASP 1142 0.0023

ASP 1142 THR 1143 0.0156

THR 1143 PRO 1144 0.0155

PRO 1144 ARG 1145 0.0094

ARG 1145 THR 1146 0.0121

THR 1146 SER 1147 0.0204

SER 1147 LEU 1148 0.0021

LEU 1148 ARG 1149 0.0785

ARG 1149 GLU 1150 0.1187

GLU 1150 ARG 1151 0.1024

ARG 1151 SER 1152 0.0321

SER 1152 ARG 1153 0.1299

ARG 1153 SER 1154 0.0824

SER 1154 THR 1155 0.0309

THR 1155 GLY 1156 0.0614

GLY 1156 LEU 1157 0.0679

LEU 1157 MET 1158 0.1264

MET 1158 ARG 1159 0.0633

ARG 1159 SER 1160 0.1311

SER 1160 VAL 1161 0.1264

VAL 1161 ASP 1162 0.1273

ASP 1162 PRO 1163 0.0786

PRO 1163 SER 1164 0.0645

SER 1164 ASN 1165 -0.2007

ASN 1165 LEU 1166 0.0306

LEU 1166 TYR 1167 0.0362

TYR 1167 SER 1168 0.0332

SER 1168 PHE 1169 0.0584

PHE 1169 LEU 1170 0.0048

LEU 1170 ARG 1171 0.0595

ARG 1171 ALA 1172 0.0264

ALA 1172 GLN 1173 0.0489

GLN 1173 GLY 1174 0.0193

GLY 1174 ILE 1175 0.0476

ILE 1175 TYR 1176 0.0590

TYR 1176 HIS 1177 0.0534

HIS 1177 GLY 1178 0.0585

GLY 1178 PRO 1179 0.0603

PRO 1179 ILE 1180 0.0180

ILE 1180 PHE 1181 0.1368

PHE 1181 GLN 1182 0.0171

GLN 1182 ASN 1183 0.0556

ASN 1183 LEU 1184 0.0354

LEU 1184 LYS 1185 0.0500

LYS 1185 THR 1186 0.0454

THR 1186 ILE 1187 0.0590

ILE 1187 SER 1188 0.0541

SER 1188 SER 1189 0.0620

SER 1189 ARG 1190 0.0536

ARG 1190 LYS 1191 0.0643

LYS 1191 ASP 1192 0.0070

ASP 1192 HIS 1193 0.0497

HIS 1193 SER 1194 0.0640

SER 1194 GLU 1195 0.0529

GLU 1195 SER 1196 0.0603

SER 1196 SER 1197 -0.0508

SER 1197 PHE 1198 0.0268

PHE 1198 VAL 1199 0.0265

VAL 1199 VAL 1200 0.0027

VAL 1200 ALA 1201 0.0492

ALA 1201 ASN 1202 0.0315

ASN 1202 THR 1203 0.0373

THR 1203 ALA 1204 0.0204

ALA 1204 SER 1205 0.0318

SER 1205 VAL 1206 0.0494

VAL 1206 MET 1207 0.0029

MET 1207 PRO 1208 0.0292

PRO 1208 ASN 1209 0.0456

ASN 1209 GLY 1210 0.0348

GLY 1210 PHE 1211 0.0221

PHE 1211 GLN 1212 0.0480

GLN 1212 SER 1213 0.0856

SER 1213 PRO 1214 0.0423

PRO 1214 HIS 1215 0.0314

HIS 1215 VAL 1216 0.0371

VAL 1216 ILE 1217 0.0092

ILE 1217 HIS 1218 0.0394

HIS 1218 PRO 1219 0.0357

PRO 1219 THR 1220 0.0161

THR 1220 THR 1221 0.0423

THR 1221 LEU 1222 0.0426

LEU 1222 ASP 1223 0.0292

ASP 1223 SER 1224 0.0225

SER 1224 ILE 1225 0.0434

ILE 1225 PHE 1226 0.0428

PHE 1226 GLN 1227 0.0187

GLN 1227 GLY 1228 0.0372

GLY 1228 ALA 1229 -0.0098

ALA 1229 TYR 1230 0.0193

TYR 1230 THR 1231 0.0458

THR 1231 ALA 1232 0.0563

ALA 1232 LEU 1233 0.0407

LEU 1233 PRO 1234 0.0000

PRO 1234 GLY 1235 0.0506

GLY 1235 ALA 1236 0.0070

ALA 1236 GLY 1237 0.0542

GLY 1237 LEU 1238 0.0294

LEU 1238 ASP 1239 0.0449

ASP 1239 GLN 1240 0.0239

GLN 1240 ASN 1241 0.0556

ASN 1241 THR 1242 0.0038

THR 1242 ALA 1243 0.0164

ALA 1243 MET 1244 0.0381

MET 1244 ILE 1245 0.0908

ILE 1245 PRO 1246 0.0254

PRO 1246 ARG 1247 0.0348

ARG 1247 SER 1248 0.0331

SER 1248 ILE 1249 0.0381

ILE 1249 GLN 1250 0.0383

GLN 1250 GLU 1251 0.0317

GLU 1251 LEU 1252 0.0374

LEU 1252 TYR 1253 0.0326

TYR 1253 LEU 1254 0.0355

LEU 1254 SER 1255 0.0361

SER 1255 SER 1256 0.0153

SER 1256 ALA 1257 0.0244

ALA 1257 LEU 1258 0.0304

LEU 1258 THR 1259 0.0371

THR 1259 SER 1260 0.0387

SER 1260 ASP 1261 0.1346

ASP 1261 VAL 1262 0.0348

VAL 1262 GLY 1263 0.0062

GLY 1263 GLN 1264 0.0560

GLN 1264 CYS 1265 0.0155

CYS 1265 LEU 1266 0.0563

LEU 1266 VAL 1267 0.0255

VAL 1267 SER 1268 0.0558

SER 1268 ASP 1269 0.0412

ASP 1269 THR 1270 0.0539

THR 1270 SER 1271 0.0480

SER 1271 LEU 1272 0.0491

LEU 1272 ILE 1273 0.0500

ILE 1273 ARG 1274 0.0480

ARG 1274 TYR 1275 0.0417

TYR 1275 ASP 1276 0.0501

ASP 1276 GLY 1277 0.1130

GLY 1277 GLN 1278 0.0161

GLN 1278 SER 1279 0.0315

SER 1279 PHE 1280 0.0530

PHE 1280 THR 1281 0.0300

THR 1281 VAL 1282 0.0526

VAL 1282 ASN 1283 0.0356

ASN 1283 VAL 1284 0.0502

VAL 1284 ASP 1285 0.0467

ASP 1285 VAL 1286 0.0495

VAL 1286 SER 1287 0.0516

SER 1287 SER 1288 0.0516

SER 1288 LYS 1289 0.0171

LYS 1289 ALA 1290 0.0376

ALA 1290 ASP 1291 0.0492

ASP 1291 SER 1292 0.0352

SER 1292 GLU 1293 0.0939

GLU 1293 HIS 1294 0.0486

HIS 1294 THR 1295 0.0153

THR 1295 PRO 1296 0.0509

PRO 1296 VAL 1297 0.0269

VAL 1297 LEU 1298 0.0478

LEU 1298 GLU 1299 0.0433

GLU 1299 ILE 1300 0.0459

ILE 1300 LYS 1301 0.0468

LYS 1301 GLY 1302 0.0394

GLY 1302 LEU 1303 0.0506

LEU 1303 ARG 1304 0.0414

ARG 1304 ASN 1305 0.0411

ASN 1305 GLN 1306 0.0471

GLN 1306 SER 1307 0.0337

SER 1307 VAL 1308 0.0424

VAL 1308 GLY 1309 0.0386

GLY 1309 GLN 1310 0.0382

GLN 1310 MET 1311 0.0036

MET 1311 ALA 1312 0.0384

ALA 1312 PRO 1313 0.0504

PRO 1313 GLN 1314 0.0053

GLN 1314 PRO 1315 0.0331

PRO 1315 GLY 1316 0.0524

GLY 1316 ASP 1317 0.0085

ASP 1317 SER 1318 0.0415

SER 1318 SER 1319 0.0312

SER 1319 ASN 1320 0.0440

ASN 1320 ASN 1321 0.0381

ASN 1321 ASP 1322 0.0405

ASP 1322 LEU 1323 0.0336

LEU 1323 CYS 1324 0.0525

CYS 1324 PHE 1325 0.0690

PHE 1325 LYS 1326 0.0140

LYS 1326 LEU 1327 0.0214

LEU 1327 ASP 1328 0.0170

ASP 1328 TRP 1329 0.0211

TRP 1329 ALA 1330 0.0211

ALA 1330 PRO 1331 0.0217

PRO 1331 ASP 1332 0.0053

ASP 1332 ILE 1333 0.0215

ILE 1333 SER 1334 0.0135

SER 1334 SER 1335 0.0124

SER 1335 VAL 1336 0.0054

VAL 1336 LYS 1337 0.0140

LYS 1337 GLN 1338 0.0180

GLN 1338 GLU 1339 0.0025

GLU 1339 ARG 1340 0.0220

ARG 1340 LEU 1341 0.4353

LEU 1341 LYS 1342 0.0245

LYS 1342 GLU 1343 0.0504

GLU 1343 LYS 1344 0.0511

LYS 1344 PHE 1345 0.0302

PHE 1345 GLY 1346 0.0350

GLY 1346 PHE 1347 0.0050

PHE 1347 PRO 1348 0.0397

PRO 1348 LEU 1349 0.0099

LEU 1349 ASP 1350 0.0242

ASP 1350 PRO 1351 0.0230

PRO 1351 THR 1352 0.0291

THR 1352 GLU 1353 0.0444

GLU 1353 ALA 1354 0.0510

ALA 1354 ASP 1355 0.0021

ASP 1355 ILE 1356 0.0502

ILE 1356 ILE 1357 0.3773

ILE 1357 MET 1358 0.1608

MET 1358 GLY 1359 0.2103

GLY 1359 LEU 1360 0.1206

LEU 1360 ARG 1361 0.2740

ARG 1361 GLN 1362 0.0287

GLN 1362 ALA 1363 0.2787

ALA 1363 CYS 1364 0.1064

CYS 1364 ILE 1365 0.2388

ILE 1365 HIS 1366 0.1312

HIS 1366 PHE 1367 0.1979

PHE 1367 ILE 1368 0.2138

ILE 1368 HIS 1369 0.1203

HIS 1369 ARG 1370 0.2389

ARG 1370 SER 1371 0.1012

SER 1371 LEU 1372 0.2727

LEU 1372 GLN 1373 0.0395

GLN 1373 SER 1374 0.3146

SER 1374 LEU 1375 0.0620

LEU 1375 THR 1376 0.3150

THR 1376 ALA 1377 0.1900

ALA 1377 PRO 1378 0.2806

PRO 1378 ASP 1379 0.3157

ASP 1379 ARG 1380 0.2445

ARG 1380 ASP 1381 0.2053

ASP 1381 GLN 1382 0.3088

GLN 1382 LEU 1383 0.3066

LEU 1383 ASP 1384 0.0665

ASP 1384 TRP 1385 0.2223

TRP 1385 HIS 1386 0.3030

HIS 1386 GLN 1387 0.0210

GLN 1387 LYS 1388 0.3138

LYS 1388 ARG 1389 0.1320

ARG 1389 PHE 1390 0.1327

PHE 1390 TYR 1391 0.2246

TYR 1391 ASP 1392 0.2623

ASP 1392 TRP 1393 0.2980

TRP 1393 MET 1394 0.0366

MET 1394 VAL 1395 0.2988

VAL 1395 LEU 1396 0.2632

LEU 1396 GLN 1397 0.2117

GLN 1397 ILE 1398 0.1309

ILE 1398 GLN 1399 0.2736

GLN 1399 LEU 1400 0.2973

LEU 1400 ALA 1401 0.0563

ALA 1401 GLU 1402 0.2712

GLU 1402 GLU 1403 0.2356

GLU 1403 ASP 1404 0.2696

ASP 1404 ARG 1405 -0.1343

ARG 1405 LEU 1406 0.3030

LEU 1406 ALA 1407 0.2010

ALA 1407 PRO 1408 0.1774

PRO 1408 ASN 1409 0.1688

ASN 1409 SER 1410 0.2415

SER 1410 SER 1411 0.2629

SER 1411 ALA 1412 0.1040

ALA 1412 TRP 1413 0.2563

TRP 1413 LEU 1414 0.3028

LEU 1414 GLN 1415 0.0022

GLN 1415 CYS 1416 0.2931

CYS 1416 SER 1417 0.1400

SER 1417 SER 1418 0.2931

SER 1418 SER 1419 0.2482

SER 1419 ASP 1420 0.2356

ASP 1420 GLU 1421 0.0766

GLU 1421 GLN 1422 0.2689

GLN 1422 LYS 1423 0.2699

LYS 1423 LEU 1424 0.1089

LEU 1424 LEU 1425 0.2095

LEU 1425 GLU 1426 0.2487

GLU 1426 ASN 1427 0.2644

ASN 1427 VAL 1428 0.0637

VAL 1428 ARG 1429 0.2655

ARG 1429 ALA 1430 0.2583

ALA 1430 SER 1431 0.2267

SER 1431 SER 1432 0.0360

SER 1432 VAL 1433 0.1758

VAL 1433 ASN 1434 0.2705

ASN 1434 GLY 1435 0.0183

GLY 1435 GLN 1436 0.2723

GLN 1436 MET 1437 0.1003

MET 1437 VAL 1438 0.2305

VAL 1438 VAL 1439 0.0773

VAL 1439 HIS 1440 0.2233

HIS 1440 VAL 1441 0.1867

VAL 1441 GLY 1442 0.1707

GLY 1442 LYS 1443 0.1446

LYS 1443 SER 1444 0.1716

SER 1444 MET 1445 0.2252

MET 1445 LEU 1446 0.2274

LEU 1446 ALA 1447 0.2539

ALA 1447 ILE 1448 0.0404

ILE 1448 LEU 1449 0.2651

LEU 1449 ARG 1450 0.2428

ARG 1450 HIS 1451 0.1479

HIS 1451 GLU 1452 0.1561

GLU 1452 ILE 1453 0.5285

ILE 1453 ALA 1454 0.0550

ALA 1454 PRO 1455 0.2279

PRO 1455 LEU 1456 0.1328

LEU 1456 GLU 1457 0.2033

GLU 1457 LEU 1458 0.0532

LEU 1458 MET 1459 0.2041

MET 1459 LEU 1460 0.1912

LEU 1460 GLN 1461 0.0723

GLN 1461 ASP 1462 0.2133

ASP 1462 LYS 1463 0.0783

LYS 1463 LEU 1464 0.1859

LEU 1464 LEU 1465 0.0746

LEU 1465 TYR 1466 0.1990

TYR 1466 ARG 1467 0.0930

ARG 1467 TYR 1468 0.2302

TYR 1468 TYR 1469 0.2773

TYR 1469 THR 1470 0.0825

THR 1470 ASP 1471 0.0199

ASP 1471 ALA 1472 0.0677

ALA 1472 ILE 1473 0.0798

ILE 1473 LYS 1474 0.0397

LYS 1474 TRP 1475 0.0404

TRP 1475 ASP 1476 0.0763

ASP 1476 ARG 1477 0.0816

ARG 1477 SER 1478 0.0569

SER 1478 TYR 1479 0.0620

TYR 1479 GLN 1480 0.0819

GLN 1480 GLN 1481 0.0737

GLN 1481 ILE 1482 0.0531

ILE 1482 ASP 1483 0.0769

ASP 1483 GLN 1484 0.0775

GLN 1484 LEU 1485 0.3251

LEU 1485 VAL 1486 0.0120

VAL 1486 LYS 1487 0.0022

LYS 1487 LEU 1488 0.0111

LEU 1488 HIS 1489 0.0100

HIS 1489 ALA 1490 0.0102

ALA 1490 HIS 1491 0.0024

HIS 1491 LYS 1492 0.0120

LYS 1492 CYS 1493 0.0099

CYS 1493 PRO 1494 0.0116

PRO 1494 THR 1495 0.0106

THR 1495 ALA 1496 0.0027

ALA 1496 LYS 1497 0.0048

LYS 1497 ILE 1498 0.0061

ILE 1498 ILE 1499 0.0003

ILE 1499 GLU 1500 0.0075

GLU 1500 ILE 1501 0.2338

ILE 1501 GLY 1502 0.0056

GLY 1502 ALA 1503 0.0208

ALA 1503 GLY 1504 0.0083

GLY 1504 THR 1505 0.0190

THR 1505 GLY 1506 0.0100

GLY 1506 GLY 1507 0.0146

GLY 1507 CYS 1508 0.0114

CYS 1508 THR 1509 0.0090

THR 1509 ARG 1510 0.0203

ARG 1510 ALA 1511 0.0209

ALA 1511 VAL 1512 0.0066

VAL 1512 LEU 1513 0.0170

LEU 1513 ASP 1514 0.0194

ASP 1514 ALA 1515 0.0176

ALA 1515 LEU 1516 0.0070

LEU 1516 SER 1517 -0.1363

SER 1517 ASN 1518 0.0047

ASN 1518 GLN 1519 0.0052

GLN 1519 GLY 1520 0.0056

GLY 1520 ILE 1521 0.0019

ILE 1521 ALA 1522 0.0056

ALA 1522 ARG 1523 0.0046

ARG 1523 CYS 1524 0.0055

CYS 1524 ALA 1525 0.0032

ALA 1525 GLN 1526 0.0028

GLN 1526 TYR 1527 0.0002

TYR 1527 ASP 1528 0.0049

ASP 1528 PHE 1529 0.0003

PHE 1529 THR 1530 0.0047

THR 1530 ASP 1531 0.0014

ASP 1531 VAL 1532 0.0051

VAL 1532 SER 1533 -0.0805

SER 1533 SER 1534 0.0106

SER 1534 GLY 1535 0.0045

GLY 1535 PHE 1536 0.0151

PHE 1536 PHE 1537 0.0007

PHE 1537 GLU 1538 0.0153

GLU 1538 ALA 1539 0.0088

ALA 1539 ALA 1540 0.0107

ALA 1540 GLN 1541 0.0043

GLN 1541 GLN 1542 0.0123

GLN 1542 LYS 1543 0.0132

LYS 1543 PHE 1544 0.0039

PHE 1544 ALA 1545 0.0085

ALA 1545 ALA 1546 0.0131

ALA 1546 PHE 1547 0.0135

PHE 1547 ASP 1548 0.0138

ASP 1548 ASP 1549 0.1545

ASP 1549 VAL 1550 0.0164

VAL 1550 ILE 1551 0.0071

ILE 1551 ARG 1552 0.0170

ARG 1552 PHE 1553 0.0059

PHE 1553 GLN 1554 0.0165

GLN 1554 LYS 1555 0.0130

LYS 1555 LEU 1556 0.0146

LEU 1556 ASP 1557 0.0152

ASP 1557 ILE 1558 0.0119

ILE 1558 GLU 1559 0.0161

GLU 1559 LYS 1560 0.0130

LYS 1560 ASP 1561 0.0007

ASP 1561 ILE 1562 0.0157

ILE 1562 GLU 1563 0.0085

GLU 1563 MET 1564 0.0100

MET 1564 GLN 1565 0.0093

GLN 1565 GLY 1566 0.0162

GLY 1566 PHE 1567 0.0210

PHE 1567 GLU 1568 0.0119

GLU 1568 CYS 1569 0.0226

CYS 1569 GLY 1570 0.0228

GLY 1570 SER 1571 0.0219

SER 1571 TYR 1572 0.0023

TYR 1572 ASP 1573 0.0199

ASP 1573 LEU 1574 0.0022

LEU 1574 VAL 1575 0.0193

VAL 1575 ILE 1576 0.0012

ILE 1576 ALA 1577 0.0167

ALA 1577 SER 1578 0.0003

SER 1578 GLN 1579 0.0167

GLN 1579 VAL 1580 0.0100

VAL 1580 LEU 1581 0.2333

LEU 1581 HIS 1582 0.0487

HIS 1582 ALA 1583 0.0624

ALA 1583 THR 1584 0.0041

THR 1584 GLY 1585 0.0473

GLY 1585 LYS 1586 0.0517

LYS 1586 MET 1587 0.0571

MET 1587 GLU 1588 0.0206

GLU 1588 HIS 1589 0.0507

HIS 1589 THR 1590 0.0312

THR 1590 MET 1591 0.0647

MET 1591 ALA 1592 0.0006

ALA 1592 ASN 1593 0.0644

ASN 1593 VAL 1594 0.0287

VAL 1594 ARG 1595 0.0444

ARG 1595 LYS 1596 0.0331

LYS 1596 LEU 1597 -0.1664

LEU 1597 LEU 1598 0.0539

LEU 1598 LYS 1599 0.0240

LYS 1599 PRO 1600 0.0496

PRO 1600 GLY 1601 0.0270

GLY 1601 GLY 1602 0.0330

GLY 1602 LYS 1603 0.0035

LYS 1603 LEU 1604 0.0359

LEU 1604 LEU 1605 0.0021

LEU 1605 LEU 1606 0.0376

LEU 1606 VAL 1607 0.0011

VAL 1607 GLU 1608 0.0520

GLU 1608 THR 1609 0.0257

THR 1609 THR 1610 0.0504

THR 1610 ARG 1611 0.0136

ARG 1611 ASP 1612 0.0399

ASP 1612 GLU 1613 -0.1197

GLU 1613 MET 1614 0.1657

MET 1614 ASP 1615 0.2272

ASP 1615 LEU 1616 0.0172

LEU 1616 GLN 1617 0.2260

GLN 1617 LEU 1618 0.1070

LEU 1618 VAL 1619 0.2245

VAL 1619 PHE 1620 0.0069

PHE 1620 GLY 1621 0.2347

GLY 1621 LEU 1622 0.2231

LEU 1622 LEU 1623 0.0579

LEU 1623 PRO 1624 0.0938

PRO 1624 GLY 1625 0.1786

GLY 1625 TRP 1626 0.1744

TRP 1626 TRP 1627 0.2154

TRP 1627 LEU 1628 0.0129

LEU 1628 SER 1629 -0.0975

SER 1629 SER 1630 0.1084

SER 1630 GLU 1631 0.1475

GLU 1631 GLU 1632 0.1023

GLU 1632 GLU 1633 0.1093

GLU 1633 ARG 1634 0.1498

ARG 1634 GLN 1635 0.1463

GLN 1635 MET 1636 0.0060

MET 1636 SER 1637 0.1516

SER 1637 PRO 1638 0.0843

PRO 1638 SER 1639 0.1463

SER 1639 LEU 1640 0.1296

LEU 1640 SER 1641 0.1232

SER 1641 THR 1642 0.1410

THR 1642 ASN 1643 0.1298

ASN 1643 SER 1644 0.1144

SER 1644 TRP 1645 0.2303

TRP 1645 GLU 1646 0.0672

GLU 1646 LYS 1647 0.0537

LYS 1647 VAL 1648 0.0750

VAL 1648 LEU 1649 0.0764

LEU 1649 LYS 1650 0.0536

LYS 1650 LYS 1651 0.0627

LYS 1651 THR 1652 0.0785

THR 1652 GLY 1653 0.0651

GLY 1653 PHE 1654 0.0328

PHE 1654 ASP 1655 0.0776

ASP 1655 GLY 1656 0.0141

GLY 1656 LEU 1657 0.0172

LEU 1657 ASP 1658 0.0795

ASP 1658 ILE 1659 0.0062

ILE 1659 GLU 1660 0.0340

GLU 1660 LEU 1661 0.1203

LEU 1661 ARG 1662 0.0183

ARG 1662 ASP 1663 0.0351

ASP 1663 CYS 1664 0.0698

CYS 1664 ASP 1665 0.0847

ASP 1665 SER 1666 0.0609

SER 1666 ASP 1667 0.0780

ASP 1667 GLU 1668 0.0224

GLU 1668 PHE 1669 0.0862

PHE 1669 TYR 1670 0.0172

TYR 1670 SER 1671 0.0821

SER 1671 PHE 1672 0.0422

PHE 1672 SER 1673 0.0181

SER 1673 VAL 1674 0.0594

VAL 1674 MET 1675 0.0172

MET 1675 MET 1676 0.0165

MET 1676 ALA 1677 -0.0041

ALA 1677 THR 1678 0.0245

THR 1678 ALA 1679 0.0070

ALA 1679 SER 1680 0.0421

SER 1680 SER 1681 0.0420

SER 1681 THR 1682 0.0235

THR 1682 ILE 1683 0.0558

ILE 1683 ALA 1684 0.0109

ALA 1684 SER 1685 0.0575

SER 1685 SER 1686 0.0570

SER 1686 SER 1687 0.0462

SER 1687 MET 1688 0.0369

MET 1688 ALA 1689 0.0553

ALA 1689 PHE 1690 0.0042

PHE 1690 ALA 1691 0.0423

ALA 1691 ILE 1692 0.0042

ILE 1692 VAL 1693 -0.2300

VAL 1693 TYR 1694 0.0223

TYR 1694 GLY 1695 0.0497

GLY 1695 GLU 1696 0.0694

GLU 1696 VAL 1697 0.0757

VAL 1697 PRO 1698 0.0384

PRO 1698 LEU 1699 0.0816

LEU 1699 PRO 1700 0.0809

PRO 1700 ASP 1701 0.0184

ASP 1701 GLN 1702 0.0794

GLN 1702 PHE 1703 0.0782

PHE 1703 LEU 1704 0.0277

LEU 1704 ASP 1705 0.0539

ASP 1705 ASP 1706 0.0685

ASP 1706 MET 1707 0.0807

MET 1707 LYS 1708 0.0073

LYS 1708 THR 1709 0.0260

THR 1709 ALA 1710 0.0651

ALA 1710 ILE 1711 0.0604

ILE 1711 SER 1712 0.0211

SER 1712 SER 1713 0.0781

SER 1713 SER 1714 0.0785

SER 1714 ALA 1715 0.0465

ALA 1715 VAL 1716 0.0105

VAL 1716 SER 1717 0.0750

SER 1717 ASP 1718 0.0508

ASP 1718 PRO 1719 0.0420

PRO 1719 VAL 1720 0.0789

VAL 1720 VAL 1721 0.0141

VAL 1721 GLY 1722 0.0709

GLY 1722 HIS 1723 0.0336

HIS 1723 LEU 1724 0.0778

LEU 1724 ASP 1725 -0.0612

ASP 1725 SER 1726 0.0190

SER 1726 ILE 1727 0.0554

ILE 1727 ASP 1728 0.0232

ASP 1728 ALA 1729 0.0545

ALA 1729 THR 1730 0.0180

THR 1730 GLY 1731 0.0541

GLY 1731 LYS 1732 0.0363

LYS 1732 PHE 1733 0.0262

PHE 1733 CYS 1734 0.0237

CYS 1734 ILE 1735 0.0166

ILE 1735 PHE 1736 0.0362

PHE 1736 ILE 1737 0.0247

ILE 1737 GLU 1738 0.0300

GLU 1738 ASP 1739 0.0323

ASP 1739 PRO 1740 0.0150

PRO 1740 GLU 1741 0.0405

GLU 1741 THR 1742 0.0331

THR 1742 ASP 1743 0.0506

ASP 1743 ILE 1744 0.0165

ILE 1744 LEU 1745 0.0507

LEU 1745 SER 1746 0.0031

SER 1746 SER 1747 0.0499

SER 1747 PRO 1748 0.0036

PRO 1748 ASP 1749 0.0458

ASP 1749 GLU 1750 0.0156

GLU 1750 LYS 1751 0.0357

LYS 1751 SER 1752 0.0453

SER 1752 TYR 1753 0.0503

TYR 1753 ALA 1754 0.0058

ALA 1754 SER 1755 0.0486

SER 1755 ILE 1756 0.0445

ILE 1756 GLN 1757 0.1054

GLN 1757 LYS 1758 0.0225

LYS 1758 LEU 1759 0.0531

LEU 1759 VAL 1760 0.0563

VAL 1760 THR 1761 0.0200

THR 1761 ARG 1762 0.0373

ARG 1762 CYS 1763 0.0525

CYS 1763 LYS 1764 0.0446

LYS 1764 GLY 1765 0.0110

GLY 1765 LEU 1766 0.0088

LEU 1766 ILE 1767 0.0226

ILE 1767 TRP 1768 0.0228

TRP 1768 VAL 1769 0.0287

VAL 1769 SER 1770 0.0043

SER 1770 ARG 1771 0.0085

ARG 1771 GLY 1772 0.0247

GLY 1772 GLY 1773 0.0366

GLY 1773 ALA 1774 0.0589

ALA 1774 MET 1775 0.0377

MET 1775 HIS 1776 0.0104

HIS 1776 GLY 1777 0.0579

GLY 1777 THR 1778 0.0414

THR 1778 ARG 1779 0.0431

ARG 1779 PRO 1780 0.0568

PRO 1780 ASN 1781 0.0386

ASN 1781 SER 1782 0.0450

SER 1782 SER 1783 0.0582

SER 1783 LEU 1784 0.0459

LEU 1784 LYS 1785 0.0246

LYS 1785 THR 1786 0.0614

THR 1786 GLY 1787 0.0616

GLY 1787 LEU 1788 0.0282

LEU 1788 LEU 1789 0.0311

LEU 1789 ARG 1790 0.0465

ARG 1790 THR 1791 0.0393

THR 1791 LEU 1792 0.0238

LEU 1792 ARG 1793 0.0431

ARG 1793 LEU 1794 0.0457

LEU 1794 GLU 1795 0.0387

GLU 1795 TYR 1796 0.0315

TYR 1796 THR 1797 0.0458

THR 1797 GLU 1798 0.0251

GLU 1798 LYS 1799 0.0273

LYS 1799 ARG 1800 0.0270

ARG 1800 PHE 1801 0.0088

PHE 1801 ILE 1802 0.0251

ILE 1802 SER 1803 0.0023

SER 1803 LEU 1804 0.0386

LEU 1804 ASP 1805 0.0140

ASP 1805 LEU 1806 0.0626

LEU 1806 ASP 1807 0.0098

ASP 1807 SER 1808 0.0426

SER 1808 ALA 1809 0.0410

ALA 1809 ARG 1810 0.0416

ARG 1810 PRO 1811 0.0644

PRO 1811 GLN 1812 0.0367

GLN 1812 TRP 1813 0.0297

TRP 1813 ASN 1814 0.0690

ASN 1814 HIS 1815 0.0388

HIS 1815 ASP 1816 0.0624

ASP 1816 SER 1817 0.0650

SER 1817 ILE 1818 0.0119

ILE 1818 THR 1819 0.0689

THR 1819 THR 1820 0.0640

THR 1820 ILE 1821 0.0979

ILE 1821 ASN 1822 0.0203

ASN 1822 GLU 1823 0.0369

GLU 1823 VAL 1824 0.0432

VAL 1824 LEU 1825 0.0062

LEU 1825 CYS 1826 0.0390

CYS 1826 GLY 1827 0.0351

GLY 1827 ALA 1828 0.0342

ALA 1828 LEU 1829 0.0101

LEU 1829 ALA 1830 0.0429

ALA 1830 GLN 1831 0.0429

GLN 1831 ASN 1832 0.0112

ASN 1832 ALA 1833 0.0421

ALA 1833 ASP 1834 0.0298

ASP 1834 SER 1835 0.0033

SER 1835 SER 1836 0.0405

SER 1836 ILE 1837 0.0189

ILE 1837 LYS 1838 0.0396

LYS 1838 ASP 1839 0.0048

ASP 1839 SER 1840 0.0416

SER 1840 GLU 1841 -0.0001

GLU 1841 PHE 1842 0.0310

PHE 1842 ALA 1843 0.0030

ALA 1843 GLU 1844 0.0349

GLU 1844 GLN 1845 0.0089

GLN 1845 ASP 1846 0.0340

ASP 1846 GLY 1847 0.0101

GLY 1847 GLN 1848 0.0321

GLN 1848 LEU 1849 0.0212

LEU 1849 PHE 1850 0.0419

PHE 1850 VAL 1851 0.0256

VAL 1851 PRO 1852 0.0410

PRO 1852 ARG 1853 0.1075

ARG 1853 ILE 1854 0.0257

ILE 1854 SER 1855 0.0242

SER 1855 CYS 1856 0.0326

CYS 1856 ASP 1857 0.0283

ASP 1857 ILE 1858 0.0265

ILE 1858 ALA 1859 0.0262

ALA 1859 ARG 1860 0.0095

ARG 1860 ASN 1861 0.0249

ASN 1861 GLU 1862 0.0164

GLU 1862 ASP 1863 0.0329

ASP 1863 LEU 1864 0.0001

LEU 1864 SER 1865 0.0329

SER 1865 SER 1866 0.0146

SER 1866 ASP 1867 0.0201

ASP 1867 SER 1868 0.0325

SER 1868 ASN 1869 0.1250

ASN 1869 SER 1870 0.0071

SER 1870 PRO 1871 0.0395

PRO 1871 ALA 1872 0.0401

ALA 1872 GLN 1873 0.0028

GLN 1873 MET 1874 0.0380

MET 1874 GLU 1875 0.0333

GLU 1875 PRO 1876 0.0385

PRO 1876 PHE 1877 0.0183

PHE 1877 HIS 1878 0.0240

HIS 1878 GLN 1879 0.0345

GLN 1879 PRO 1880 0.0332

PRO 1880 GLY 1881 0.0328

GLY 1881 LYS 1882 0.0225

LYS 1882 LEU 1883 0.0040

LEU 1883 LEU 1884 0.0329

LEU 1884 GLN 1885 -0.0281

GLN 1885 MET 1886 0.0252

MET 1886 GLY 1887 0.0058

GLY 1887 ILE 1888 0.0218

ILE 1888 LYS 1889 0.0288

LYS 1889 THR 1890 0.0110

THR 1890 PRO 1891 0.0232

PRO 1891 GLY 1892 0.0294

GLY 1892 LEU 1893 0.0073

LEU 1893 ILE 1894 0.0138

ILE 1894 ASP 1895 0.0170

ASP 1895 THR 1896 0.0287

THR 1896 LEU 1897 0.0239

LEU 1897 GLN 1898 0.0193

GLN 1898 PHE 1899 0.0240

PHE 1899 SER 1900 0.0289

SER 1900 LYS 1901 0.0831

LYS 1901 THR 1902 0.0471

THR 1902 ASP 1903 0.0500

ASP 1903 ALA 1904 0.0562

ALA 1904 THR 1905 0.0521

THR 1905 ASP 1906 0.0389

ASP 1906 ASN 1907 0.0281

ASN 1907 LEU 1908 0.0418

LEU 1908 PRO 1909 0.0168

PRO 1909 ASN 1910 0.0577

ASN 1910 ASP 1911 0.0296

ASP 1911 TYR 1912 0.0479

TYR 1912 ILE 1913 0.0381

ILE 1913 GLU 1914 0.0343

GLU 1914 ILE 1915 0.0581

ILE 1915 GLU 1916 0.0344

GLU 1916 PRO 1917 -0.0292

PRO 1917 LYS 1918 0.0180

LYS 1918 ALA 1919 0.0181

ALA 1919 PHE 1920 0.0084

PHE 1920 GLY 1921 0.0141

GLY 1921 LEU 1922 0.0275

LEU 1922 ASN 1923 0.0015

ASN 1923 PHE 1924 0.0208

PHE 1924 ARG 1925 0.0237

ARG 1925 ASP 1926 0.0062

ASP 1926 VAL 1927 0.0283

VAL 1927 MET 1928 0.0039

MET 1928 VAL 1929 0.0272

VAL 1929 ALA 1930 0.0075

ALA 1930 MET 1931 0.0207

MET 1931 GLY 1932 0.0154

GLY 1932 GLN 1933 -0.1248

GLN 1933 LEU 1934 0.0311

LEU 1934 GLU 1935 0.0320

GLU 1935 GLU 1936 0.0282

GLU 1936 SER 1937 0.0022

SER 1937 ILE 1938 0.0346

ILE 1938 MET 1939 0.0198

MET 1939 GLY 1940 0.0309

GLY 1940 PHE 1941 0.0197

PHE 1941 GLU 1942 0.0271

GLU 1942 CYS 1943 0.0088

CYS 1943 ALA 1944 0.0278

ALA 1944 GLY 1945 0.0231

GLY 1945 VAL 1946 0.0343

VAL 1946 VAL 1947 0.0260

VAL 1947 ARG 1948 0.0265

ARG 1948 ARG 1949 0.0854

ARG 1949 VAL 1950 0.0208

VAL 1950 GLY 1951 0.0399

GLY 1951 PRO 1952 0.0537

PRO 1952 SER 1953 0.0059

SER 1953 SER 1954 0.0526

SER 1954 ALA 1955 0.0279

ALA 1955 GLY 1956 0.0266

GLY 1956 HIS 1957 0.0454

HIS 1957 ASN 1958 0.0286

ASN 1958 ILE 1959 0.0430

ILE 1959 LYS 1960 0.0015

LYS 1960 VAL 1961 0.0253

VAL 1961 GLY 1962 0.0477

GLY 1962 ASP 1963 0.0128

ASP 1963 ARG 1964 0.0511

ARG 1964 VAL 1965 0.0077

VAL 1965 CYS 1966 0.0257

CYS 1966 ALA 1967 0.0318

ALA 1967 LEU 1968 0.0159

LEU 1968 LEU 1969 0.0472

LEU 1969 GLY 1970 0.0369

GLY 1970 GLY 1971 0.0451

GLY 1971 GLN 1972 0.0048

GLN 1972 TRP 1973 0.0252

TRP 1973 THR 1974 0.0210

THR 1974 ASN 1975 0.0081

ASN 1975 THR 1976 0.0457

THR 1976 VAL 1977 0.0058

VAL 1977 ARG 1978 0.0384

ARG 1978 VAL 1979 0.0157

VAL 1979 HIS 1980 0.0329

HIS 1980 TRP 1981 0.0804

TRP 1981 HIS 1982 0.0143

HIS 1982 SER 1983 0.0445

SER 1983 VAL 1984 0.0200

VAL 1984 ALA 1985 0.0515

ALA 1985 PRO 1986 0.0195

PRO 1986 ILE 1987 0.0453

ILE 1987 PRO 1988 0.0466

PRO 1988 GLN 1989 0.0009

GLN 1989 ALA 1990 0.0516

ALA 1990 MET 1991 0.0403

MET 1991 ASP 1992 0.0374

ASP 1992 TRP 1993 0.0507

TRP 1993 GLU 1994 0.0469

GLU 1994 THR 1995 0.0272

THR 1995 ALA 1996 0.0498

ALA 1996 ALA 1997 -0.0059

ALA 1997 SER 1998 0.0216

SER 1998 ILE 1999 0.0074

ILE 1999 PRO 2000 0.0226

PRO 2000 ILE 2001 0.0240

ILE 2001 VAL 2002 0.0261

VAL 2002 PHE 2003 0.0200

PHE 2003 VAL 2004 0.0215

VAL 2004 THR 2005 0.0249

THR 2005 ALA 2006 0.0241

ALA 2006 TYR 2007 0.0225

TYR 2007 ILE 2008 0.0210

ILE 2008 SER 2009 0.0249

SER 2009 LEU 2010 0.0248

LEU 2010 VAL 2011 0.0256

VAL 2011 LYS 2012 0.0246

LYS 2012 ILE 2013 0.1386

ILE 2013 ALA 2014 0.0083

ALA 2014 ARG 2015 0.0072

ARG 2015 MET 2016 0.0091

MET 2016 GLN 2017 0.0059

GLN 2017 ALA 2018 0.0091

ALA 2018 GLY 2019 0.0087

GLY 2019 GLU 2020 0.0086

GLU 2020 THR 2021 0.0052

THR 2021 VAL 2022 0.0027

VAL 2022 LEU 2023 0.0048

LEU 2023 ILE 2024 0.0017

ILE 2024 HIS 2025 0.0047

HIS 2025 ALA 2026 0.0005

ALA 2026 ALA 2027 0.0083

ALA 2027 SER 2028 0.0016

SER 2028 GLY 2029 0.0681

GLY 2029 GLY 2030 0.0211

GLY 2030 VAL 2031 0.0037

VAL 2031 GLY 2032 0.0184

GLY 2032 GLN 2033 0.0183

GLN 2033 ALA 2034 0.0189

ALA 2034 ALA 2035 0.0040

ALA 2035 ILE 2036 0.0211

ILE 2036 ILE 2037 0.0199

ILE 2037 LEU 2038 0.0099

LEU 2038 ALA 2039 0.0123

ALA 2039 LYS 2040 0.0203

LYS 2040 HIS 2041 0.0209

HIS 2041 VAL 2042 0.0038

VAL 2042 GLY 2043 0.0202

GLY 2043 ALA 2044 0.0211

ALA 2044 GLU 2045 -0.0891

GLU 2045 ILE 2046 0.0054

ILE 2046 PHE 2047 0.0129

PHE 2047 ALA 2048 0.0026

ALA 2048 THR 2049 0.0102

THR 2049 VAL 2050 0.0011

VAL 2050 GLY 2051 0.0088

GLY 2051 THR 2052 0.0101

THR 2052 ASP 2053 0.0128

ASP 2053 GLU 2054 0.0061

GLU 2054 LYS 2055 0.0096

LYS 2055 ARG 2056 0.0044

ARG 2056 ASP 2057 0.0098

ASP 2057 LEU 2058 0.0122

LEU 2058 LEU 2059 0.0013

LEU 2059 ILE 2060 0.0118

ILE 2060 LYS 2061 0.0196

LYS 2061 GLU 2062 0.0101

GLU 2062 TYR 2063 0.0036

TYR 2063 LYS 2064 0.0054

LYS 2064 ILE 2065 0.0090

ILE 2065 PRO 2066 0.0073

PRO 2066 ASP 2067 0.0086

ASP 2067 ASP 2068 0.0036

ASP 2068 HIS 2069 0.0102

HIS 2069 ILE 2070 0.0017

ILE 2070 PHE 2071 0.0103

PHE 2071 SER 2072 0.0046

SER 2072 SER 2073 0.0094

SER 2073 ARG 2074 0.0089

ARG 2074 ASN 2075 0.0023

ASN 2075 ALA 2076 0.0021

ALA 2076 LEU 2077 0.0783

LEU 2077 PHE 2078 0.0072

PHE 2078 ALA 2079 0.0070

ALA 2079 LYS 2080 0.0085

LYS 2080 SER 2081 0.0096

SER 2081 ILE 2082 0.0075

ILE 2082 ARG 2083 0.0066

ARG 2083 GLN 2084 0.0093

GLN 2084 ARG 2085 0.0092

ARG 2085 THR 2086 0.0070

THR 2086 ASN 2087 0.0074

ASN 2087 GLY 2088 0.0078

GLY 2088 LYS 2089 0.0089

LYS 2089 GLY 2090 0.0019

GLY 2090 VAL 2091 0.0096

VAL 2091 ASP 2092 0.0078

ASP 2092 VAL 2093 -0.0063

VAL 2093 VAL 2094 0.0002

VAL 2094 LEU 2095 0.0045

LEU 2095 ASN 2096 0.0023

ASN 2096 CYS 2097 0.0010

CYS 2097 LEU 2098 0.0060

LEU 2098 ALA 2099 0.0063

ALA 2099 GLY 2100 0.0072

GLY 2100 GLY 2101 0.0065

GLY 2101 LEU 2102 0.0068

LEU 2102 LEU 2103 0.0048

LEU 2103 GLN 2104 0.0060

GLN 2104 GLU 2105 0.0074

GLU 2105 SER 2106 0.0059

SER 2106 PHE 2107 0.0049

PHE 2107 ASP 2108 0.0070

ASP 2108 CYS 2109 -0.0359

CYS 2109 LEU 2110 0.0050

LEU 2110 ALA 2111 0.0006

ALA 2111 ASP 2112 0.0050

ASP 2112 PHE 2113 0.0088

PHE 2113 GLY 2114 0.0031

GLY 2114 ARG 2115 0.0068

ARG 2115 PHE 2116 -0.0001

PHE 2116 ILE 2117 0.0073

ILE 2117 GLU 2118 0.0008

GLU 2118 ILE 2119 0.0065

ILE 2119 GLY 2120 0.0019

GLY 2120 LYS 2121 0.0073

LYS 2121 ARG 2122 0.0044

ARG 2122 ASP 2123 0.0070

ASP 2123 ILE 2124 0.0068

ILE 2124 GLU 2125 0.0738

GLU 2125 LEU 2126 0.0003

LEU 2126 ASN 2127 0.0025

ASN 2127 HIS 2128 0.0022

HIS 2128 CYS 2129 0.0028

CYS 2129 LEU 2130 0.0015

LEU 2130 ASN 2131 0.0026

ASN 2131 MET 2132 0.0015

MET 2132 GLY 2133 0.0026

GLY 2133 MET 2134 0.0011

MET 2134 PHE 2135 0.0013

PHE 2135 ALA 2136 0.0027

ALA 2136 ARG 2137 0.0023

ARG 2137 SER 2138 0.0012

SER 2138 ALA 2139 0.0025

ALA 2139 THR 2140 0.0023

THR 2140 PHE 2141 0.0955

PHE 2141 THR 2142 0.0282

THR 2142 ALA 2143 0.0165

ALA 2143 VAL 2144 0.0245

VAL 2144 ASP 2145 0.0253

ASP 2145 LEU 2146 0.0263

LEU 2146 ILE 2147 0.0305

ILE 2147 ALA 2148 0.0015

ALA 2148 ILE 2149 0.0298

ILE 2149 GLY 2150 0.0200

GLY 2150 ARG 2151 0.0241

ARG 2151 ASP 2152 0.0029

ASP 2152 ARG 2153 0.0310

ARG 2153 SER 2154 0.0130

SER 2154 TYR 2155 0.0241

TYR 2155 MET 2156 0.0284

MET 2156 PHE 2157 0.0500

PHE 2157 ALA 2158 0.0352

ALA 2158 GLU 2159 0.0228

GLU 2159 ALA 2160 0.0323

ALA 2160 LEU 2161 0.0004

LEU 2161 PRO 2162 0.0350

PRO 2162 LYS 2163 0.0219

LYS 2163 ILE 2164 0.0274

ILE 2164 MET 2165 0.0099

MET 2165 THR 2166 0.0303

THR 2166 LEU 2167 0.0324

LEU 2167 LEU 2168 0.0061

LEU 2168 GLN 2169 0.0294

GLN 2169 GLU 2170 0.0227

GLU 2170 LYS 2171 0.0339

LYS 2171 ALA 2172 0.0013

ALA 2172 ILE 2173 0.0581

ILE 2173 ARG 2174 0.0175

ARG 2174 PRO 2175 0.0294

PRO 2175 VAL 2176 0.0269

VAL 2176 THR 2177 0.0221

THR 2177 PRO 2178 0.0214

PRO 2178 ILE 2179 0.0275

ILE 2179 SER 2180 0.0281

SER 2180 ILE 2181 0.0153

ILE 2181 TYR 2182 0.0296

TYR 2182 LYS 2183 0.0202

LYS 2183 ILE 2184 0.0246

ILE 2184 GLY 2185 0.0237

GLY 2185 ASP 2186 0.0235

ASP 2186 ILE 2187 0.0063

ILE 2187 GLU 2188 0.0258

GLU 2188 THR 2189 0.1397

THR 2189 ALA 2190 0.0176

ALA 2190 PHE 2191 0.0157

PHE 2191 ARG 2192 0.0283

ARG 2192 LEU 2193 0.0279

LEU 2193 MET 2194 0.0096

MET 2194 GLN 2195 0.0247

GLN 2195 ALA 2196 0.0280

ALA 2196 GLY 2197 0.0202

GLY 2197 LYS 2198 0.0159

LYS 2198 HIS 2199 0.0269

HIS 2199 MET 2200 0.0253

MET 2200 GLY 2201 0.0281

GLY 2201 LYS 2202 0.0235

LYS 2202 ILE 2203 0.0134

ILE 2203 VAL 2204 0.0193

VAL 2204 ILE 2205 0.2614

ILE 2205 THR 2206 0.0032

THR 2206 ALA 2207 0.0191

ALA 2207 PRO 2208 0.0032

PRO 2208 GLU 2209 0.0131

GLU 2209 ASP 2210 0.0273

ASP 2210 ALA 2211 0.0032

ALA 2211 MET 2212 0.0279

MET 2212 VAL 2213 0.0070

VAL 2213 PRO 2214 0.0255

PRO 2214 VAL 2215 0.0280

VAL 2215 ILE 2216 0.0254

ILE 2216 THR 2217 0.0215

THR 2217 ARG 2218 0.0158

ARG 2218 PRO 2219 0.0240

PRO 2219 PRO 2220 0.0282

PRO 2220 LYS 2221 0.9411

LYS 2221 LEU 2222 0.0221

LEU 2222 GLN 2223 0.0134

GLN 2223 LEU 2224 0.0222

LEU 2224 ARG 2225 0.0046

ARG 2225 PRO 2226 0.0323

PRO 2226 ASP 2227 0.0026

ASP 2227 ALA 2228 0.0308

ALA 2228 SER 2229 0.0280

SER 2229 TYR 2230 0.0127

TYR 2230 LEU 2231 0.0325

LEU 2231 ILE 2232 0.0061

ILE 2232 VAL 2233 0.0323

VAL 2233 GLY 2234 0.0096

GLY 2234 GLY 2235 0.0324

GLY 2235 LEU 2236 0.0237

LEU 2236 GLY 2237 -0.0100

GLY 2237 GLY 2238 0.0083

GLY 2238 ILE 2239 0.0232

ILE 2239 GLY 2240 0.0048

GLY 2240 ARG 2241 0.0224

ARG 2241 SER 2242 0.0195

SER 2242 LEU 2243 0.0077

LEU 2243 CYS 2244 0.0203

CYS 2244 LYS 2245 0.0136

LYS 2245 ASN 2246 0.0260

ASN 2246 PHE 2247 0.0000

PHE 2247 VAL 2248 0.0260

VAL 2248 GLU 2249 0.0122

GLU 2249 ASN 2250 0.0200

ASN 2250 GLY 2251 0.0075

GLY 2251 ALA 2252 0.0208

ALA 2252 ARG 2253 0.0246

ARG 2253 SER 2254 0.0315

SER 2254 LEU 2255 0.0255

LEU 2255 VAL 2256 0.0335

VAL 2256 LEU 2257 0.0191

LEU 2257 LEU 2258 0.0356

LEU 2258 SER 2259 0.0271

SER 2259 ARG 2260 0.0358

ARG 2260 ASN 2261 0.0351

ASN 2261 ALA 2262 0.0307

ALA 2262 ASN 2263 0.0360

ASN 2263 VAL 2264 0.0025

VAL 2264 SER 2265 0.0333

SER 2265 GLN 2266 0.0213

GLN 2266 GLN 2267 0.0124

GLN 2267 SER 2268 0.0311

SER 2268 GLY 2269 -0.1139

GLY 2269 GLU 2270 0.0103

GLU 2270 PHE 2271 0.0334

PHE 2271 LEU 2272 0.0031

LEU 2272 ASP 2273 0.0338

ASP 2273 GLU 2274 0.0093

GLU 2274 LEU 2275 0.0267

LEU 2275 ARG 2276 0.0131

ARG 2276 SER 2277 0.0224

SER 2277 THR 2278 0.0318

THR 2278 GLY 2279 0.0030

GLY 2279 CYS 2280 0.0335

CYS 2280 ILE 2281 0.0072

ILE 2281 VAL 2282 0.0321

VAL 2282 GLY 2283 0.0152

GLY 2283 VAL 2284 0.0317

VAL 2284 VAL 2285 0.2694

VAL 2285 ASP 2286 0.0337

ASP 2286 CYS 2287 0.0436

CYS 2287 ASP 2288 0.0277

ASP 2288 ILE 2289 0.0417

ILE 2289 SER 2290 0.0384

SER 2290 SER 2291 0.0169

SER 2291 LYS 2292 0.0155

LYS 2292 THR 2293 0.0286

THR 2293 GLN 2294 0.0359

GLN 2294 VAL 2295 0.0433

VAL 2295 GLU 2296 0.0031

GLU 2296 ALA 2297 0.0421

ALA 2297 THR 2298 0.0320

THR 2298 MET 2299 0.0342

MET 2299 LEU 2300 0.0098

LEU 2300 ARG 2301 0.0935

ARG 2301 LEU 2302 0.0347

LEU 2302 LYS 2303 0.0093

LYS 2303 LYS 2304 0.0337

LYS 2304 ASP 2305 0.0196

ASP 2305 MET 2306 0.0330

MET 2306 LEU 2307 0.0371

LEU 2307 PRO 2308 0.0391

PRO 2308 ILE 2309 0.0096

ILE 2309 ARG 2310 0.0375

ARG 2310 GLY 2311 0.0026

GLY 2311 ILE 2312 0.0216

ILE 2312 VAL 2313 0.0001

VAL 2313 HIS 2314 0.0335

HIS 2314 ALA 2315 0.0068

ALA 2315 GLY 2316 0.0396

GLY 2316 MET 2317 -0.1398

MET 2317 VAL 2318 0.0225

VAL 2318 LEU 2319 0.0050

LEU 2319 GLN 2320 0.0245

GLN 2320 ASP 2321 0.0185

ASP 2321 SER 2322 0.0221

SER 2322 VAL 2323 0.0331

VAL 2323 PHE 2324 0.0451

PHE 2324 GLU 2325 0.0191

GLU 2325 ARG 2326 0.0506

ARG 2326 MET 2327 0.0001

MET 2327 SER 2328 0.0457

SER 2328 LEU 2329 0.0194

LEU 2329 ASP 2330 0.0406

ASP 2330 ASP 2331 0.0484

ASP 2331 TYR 2332 0.0477

TYR 2332 ASN 2333 -0.0703

ASN 2333 THR 2334 0.0494

THR 2334 ALA 2335 0.0486

ALA 2335 ILE 2336 0.0324

ILE 2336 ARG 2337 0.0198

ARG 2337 PRO 2338 0.0420

PRO 2338 LYS 2339 0.0486

LYS 2339 VAL 2340 0.0469

VAL 2340 GLN 2341 0.0316

GLN 2341 GLY 2342 0.0442

GLY 2342 SER 2343 0.0462

SER 2343 TRP 2344 0.0403

TRP 2344 ASN 2345 0.0373

ASN 2345 LEU 2346 0.0448

LEU 2346 HIS 2347 0.0462

HIS 2347 SER 2348 0.0365

SER 2348 GLY 2349 0.1144

GLY 2349 LEU 2350 0.0383

LEU 2350 SER 2351 0.0321

SER 2351 ASP 2352 0.0124

ASP 2352 CYS 2353 0.0389

CYS 2353 ASP 2354 0.0406

ASP 2354 LEU 2355 0.0086

LEU 2355 ASP 2356 0.0419

ASP 2356 PHE 2357 0.0028

PHE 2357 PHE 2358 0.0258

PHE 2358 ILE 2359 0.0040

ILE 2359 MET 2360 0.0163

MET 2360 LEU 2361 0.0097

LEU 2361 SER 2362 0.0300

SER 2362 SER 2363 0.0030

SER 2363 LEU 2364 0.0297

LEU 2364 ALA 2365 0.1523

ALA 2365 GLY 2366 0.0417

GLY 2366 VAL 2367 0.0576

VAL 2367 SER 2368 0.0096

SER 2368 GLY 2369 0.0475

GLY 2369 SER 2370 0.0448

SER 2370 ALA 2371 0.0148

ALA 2371 SER 2372 0.0574

SER 2372 GLN 2373 0.0005

GLN 2373 ALA 2374 0.0570

ALA 2374 ASN 2375 0.0281

ASN 2375 TYR 2376 0.0451

TYR 2376 THR 2377 0.0575

THR 2377 ALA 2378 0.0498

ALA 2378 GLY 2379 0.0251

GLY 2379 GLY 2380 0.0564

GLY 2380 ALA 2381 0.0466

ALA 2381 TYR 2382 0.0258

TYR 2382 GLN 2383 0.0381

GLN 2383 ASP 2384 0.0519

ASP 2384 ALA 2385 0.0465

ALA 2385 LEU 2386 0.0264

LEU 2386 ALA 2387 0.0473

ALA 2387 LYS 2388 0.0518

LYS 2388 TYR 2389 0.0416

TYR 2389 ARG 2390 0.0295

ARG 2390 ARG 2391 0.0504

ARG 2391 ALA 2392 0.0514

ALA 2392 GLN 2393 0.0279

GLN 2393 GLY 2394 0.0417

GLY 2394 LEU 2395 0.0475

LEU 2395 SER 2396 0.0426

SER 2396 ALA 2397 -0.0547

ALA 2397 VAL 2398 0.0077

VAL 2398 SER 2399 0.0039

SER 2399 ILE 2400 0.0165

ILE 2400 ASP 2401 0.0033

ASP 2401 LEU 2402 0.0253

LEU 2402 GLY 2403 0.0037

GLY 2403 MET 2404 0.0206

MET 2404 VAL 2405 0.0199

VAL 2405 GLN 2406 0.0180

GLN 2406 SER 2407 0.0198

SER 2407 VAL 2408 0.0193

VAL 2408 GLY 2409 0.0274

GLY 2409 TYR 2410 0.0122

TYR 2410 VAL 2411 0.0154

VAL 2411 ALA 2412 0.0268

ALA 2412 GLU 2413 0.1307

GLU 2413 THR 2414 0.0101

THR 2414 LYS 2415 0.0140

LYS 2415 GLY 2416 0.0292

GLY 2416 VAL 2417 0.0238

VAL 2417 ALA 2418 0.0365

ALA 2418 GLU 2419 0.0079

GLU 2419 ARG 2420 0.0391

ARG 2420 LEU 2421 0.0123

LEU 2421 VAL 2422 0.0408

VAL 2422 ARG 2423 0.0063

ARG 2423 MET 2424 0.0353

MET 2424 GLY 2425 0.0269

GLY 2425 TYR 2426 0.0131

TYR 2426 SER 2427 0.0296

SER 2427 PRO 2428 0.0353

PRO 2428 ILE 2429 0.1085

ILE 2429 SER 2430 0.0391

SER 2430 GLU 2431 0.0164

GLU 2431 MET 2432 0.0347

MET 2432 GLU 2433 0.0404

GLU 2433 VAL 2434 0.0333

VAL 2434 LEU 2435 0.0187

LEU 2435 LYS 2436 0.0406

LYS 2436 ILE 2437 0.0407

ILE 2437 VAL 2438 0.0214

VAL 2438 GLU 2439 0.0311

GLU 2439 HIS 2440 0.0405

HIS 2440 ALA 2441 0.0372

ALA 2441 ILE 2442 0.0155

ILE 2442 THR 2443 0.0393

THR 2443 ASN 2444 0.0385

ASN 2444 PRO 2445 0.1050

PRO 2445 PRO 2446 0.0284

PRO 2446 PRO 2447 0.0117

PRO 2447 GLU 2448 0.0268

GLU 2448 ALA 2449 0.0257

ALA 2449 SER 2450 0.0110

SER 2450 SER 2451 0.0310

SER 2451 ALA 2452 0.0315

ALA 2452 GLN 2453 0.0006

GLN 2453 ILE 2454 0.0260

ILE 2454 ILE 2455 0.0005

ILE 2455 THR 2456 0.0231

THR 2456 GLY 2457 0.0039

GLY 2457 ILE 2458 0.0258

ILE 2458 SER 2459 0.0199

SER 2459 THR 2460 0.0300

THR 2460 LYS 2461 0.0555

LYS 2461 PRO 2462 0.0089

PRO 2462 GLY 2463 0.0057

GLY 2463 ARG 2464 0.0033

ARG 2464 HIS 2465 0.0179

HIS 2465 TRP 2466 0.0198

TRP 2466 THR 2467 0.0012

THR 2467 GLU 2468 0.0180

GLU 2468 SER 2469 0.0122

SER 2469 SER 2470 0.0193

SER 2470 TRP 2471 0.0043

TRP 2471 LEU 2472 0.0168

LEU 2472 GLN 2473 0.0147

GLN 2473 ASP 2474 0.0162

ASP 2474 ALA 2475 0.0138

ALA 2475 ARG 2476 0.0079

ARG 2476 PHE 2477 0.1402

PHE 2477 ALA 2478 0.0196

ALA 2478 THR 2479 0.0004

THR 2479 LEU 2480 0.0195

LEU 2480 ARG 2481 0.0090

ARG 2481 GLU 2482 0.0162

GLU 2482 ARG 2483 0.0046

ARG 2483 ALA 2484 0.0149

ALA 2484 ARG 2485 0.0169

ARG 2485 ASP 2486 0.0039

ASP 2486 VAL 2487 0.0177

VAL 2487 LYS 2488 0.0083

LYS 2488 GLU 2489 0.0194

GLU 2489 LEU 2490 0.0002

LEU 2490 SER 2491 0.0186

SER 2491 ASN 2492 0.0153

ASN 2492 SER 2493 -0.0155

SER 2493 GLN 2494 0.0051

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** sdgklnrdh ***

CA strain for 22101813491974862

--- normal mode 25 ---

Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *