Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *

CA strain for 22101813491974862

--- normal mode 24 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
ASN 989 LYS 990 0.0242

LYS 990 ALA 991 0.0105

ALA 991 HIS 992 0.0184

HIS 992 ARG 993 0.0089

ARG 993 GLN 994 0.0162

GLN 994 ARG 995 0.0171

ARG 995 VAL 996 0.0231

VAL 996 HIS 997 0.0214

HIS 997 PRO 998 0.0185

PRO 998 PRO 999 0.0187

PRO 999 HIS 1000 0.0137

HIS 1000 ASP 1001 0.0240

ASP 1001 LEU 1002 0.0003

LEU 1002 LEU 1003 0.0239

LEU 1003 GLY 1004 0.0083

GLY 1004 SER 1005 -0.2560

SER 1005 LEU 1006 0.0234

LEU 1006 ILE 1007 0.0293

ILE 1007 VAL 1008 0.0203

VAL 1008 GLY 1009 0.0246

GLY 1009 ARG 1010 0.0032

ARG 1010 ASP 1011 0.0215

ASP 1011 LEU 1012 0.0293

LEU 1012 ARG 1013 0.0016

ARG 1013 GLU 1014 0.0288

GLU 1014 PRO 1015 0.0107

PRO 1015 THR 1016 0.0286

THR 1016 TRP 1017 0.0182

TRP 1017 ARG 1018 0.0253

ARG 1018 HIS 1019 0.0277

HIS 1019 PHE 1020 0.0247

PHE 1020 ILE 1021 -0.6061

ILE 1021 ARG 1022 0.0235

ARG 1022 VAL 1023 0.0268

VAL 1023 GLN 1024 0.0029

GLN 1024 ASP 1025 0.0241

ASP 1025 ILE 1026 0.0162

ILE 1026 PRO 1027 0.0259

PRO 1027 TRP 1028 0.0201

TRP 1028 ILE 1029 0.0114

ILE 1029 ARG 1030 0.0262

ARG 1030 ASP 1031 0.0246

ASP 1031 HIS 1032 0.0123

HIS 1032 VAL 1033 0.0116

VAL 1033 VAL 1034 0.0027

VAL 1034 GLN 1035 0.0142

GLN 1035 SER 1036 0.0129

SER 1036 ALA 1037 0.0685

ALA 1037 LEU 1038 0.0075

LEU 1038 VAL 1039 0.0264

VAL 1039 TYR 1040 0.0191

TYR 1040 PRO 1041 0.0283

PRO 1041 GLY 1042 0.0192

GLY 1042 ALA 1043 0.0156

ALA 1043 GLY 1044 0.0175

GLY 1044 PHE 1045 0.0221

PHE 1045 ILE 1046 0.0291

ILE 1046 CYS 1047 0.0019

CYS 1047 MET 1048 0.0292

MET 1048 ALA 1049 0.0247

ALA 1049 MET 1050 0.0178

MET 1050 GLU 1051 0.0109

GLU 1051 ALA 1052 0.0262

ALA 1052 MET 1053 0.0860

MET 1053 VAL 1054 0.0085

VAL 1054 GLN 1055 0.0073

GLN 1055 LEU 1056 0.0089

LEU 1056 HIS 1057 0.0140

HIS 1057 GLU 1058 0.0015

GLU 1058 LEU 1059 0.0147

LEU 1059 ARG 1060 0.0058

ARG 1060 ASP 1061 0.0144

ASP 1061 SER 1062 0.0090

SER 1062 GLN 1063 0.0068

GLN 1063 SER 1064 0.0153

SER 1064 ARG 1065 0.0017

ARG 1065 LYS 1066 0.0153

LYS 1066 VAL 1067 0.0138

VAL 1067 ALA 1068 0.0062

ALA 1068 GLY 1069 0.1178

GLY 1069 TYR 1070 0.0123

TYR 1070 ARG 1071 0.0008

ARG 1071 LEU 1072 0.0112

LEU 1072 ALA 1073 0.0013

ALA 1073 GLU 1074 0.0073

GLU 1074 VAL 1075 0.0169

VAL 1075 ASP 1076 0.0128

ASP 1076 ILE 1077 0.0201

ILE 1077 LEU 1078 0.0139

LEU 1078 ARG 1079 0.0192

ARG 1079 ALA 1080 0.0136

ALA 1080 MET 1081 0.0067

MET 1081 LEU 1082 0.0208

LEU 1082 ILE 1083 0.0021

ILE 1083 PRO 1084 0.0203

PRO 1084 ASP 1085 0.0216

ASP 1085 THR 1086 0.0218

THR 1086 SER 1087 0.0098

SER 1087 GLU 1088 0.0217

GLU 1088 GLY 1089 0.0167

GLY 1089 LEU 1090 0.0105

LEU 1090 GLU 1091 0.0307

GLU 1091 ALA 1092 0.0214

ALA 1092 HIS 1093 0.0292

HIS 1093 ILE 1094 0.0269

ILE 1094 SER 1095 0.0269

SER 1095 LEU 1096 0.0285

LEU 1096 ARG 1097 0.0186

ARG 1097 PRO 1098 0.0284

PRO 1098 CYS 1099 0.0020

CYS 1099 SER 1100 0.0232

SER 1100 THR 1101 0.0737

THR 1101 LYS 1102 0.0009

LYS 1102 LEU 1103 0.0218

LEU 1103 LEU 1104 0.0221

LEU 1104 LEU 1105 0.0049

LEU 1105 THR 1106 0.0148

THR 1106 ASN 1107 0.0067

ASN 1107 GLU 1108 0.0180

GLU 1108 TRP 1109 0.0201

TRP 1109 TYR 1110 0.0208

TYR 1110 ASP 1111 0.0162

ASP 1111 PHE 1112 0.0131

PHE 1112 CYS 1113 0.0223

CYS 1113 VAL 1114 0.0148

VAL 1114 SER 1115 0.0223

SER 1115 SER 1116 0.0170

SER 1116 VAL 1117 -0.0013

VAL 1117 GLY 1118 0.0139

GLY 1118 ASP 1119 0.0121

ASP 1119 ASP 1120 0.0080

ASP 1120 ASP 1121 0.0131

ASP 1121 LYS 1122 0.0034

LYS 1122 PHE 1123 0.0144

PHE 1123 VAL 1124 0.0114

VAL 1124 ASP 1125 0.0135

ASP 1125 HIS 1126 0.0142

HIS 1126 CYS 1127 0.0139

CYS 1127 ARG 1128 0.0124

ARG 1128 GLY 1129 0.0141

GLY 1129 ARG 1130 0.0137

ARG 1130 ILE 1131 0.0049

ILE 1131 THR 1132 0.0127

THR 1132 ILE 1133 0.1109

ILE 1133 GLU 1134 0.0165

GLU 1134 PHE 1135 0.0151

PHE 1135 ASP 1136 0.0067

ASP 1136 THR 1137 0.0226

THR 1137 SER 1138 0.0097

SER 1138 GLY 1139 0.0234

GLY 1139 SER 1140 0.0217

SER 1140 ALA 1141 0.0098

ALA 1141 ASP 1142 0.0244

ASP 1142 THR 1143 0.0106

THR 1143 PRO 1144 0.0137

PRO 1144 ARG 1145 0.0199

ARG 1145 THR 1146 0.0235

THR 1146 SER 1147 0.0092

SER 1147 LEU 1148 0.0223

LEU 1148 ARG 1149 -0.5069

ARG 1149 GLU 1150 0.0089

GLU 1150 ARG 1151 0.0046

ARG 1151 SER 1152 0.0122

SER 1152 ARG 1153 0.0112

ARG 1153 SER 1154 0.0006

SER 1154 THR 1155 0.0093

THR 1155 GLY 1156 0.0104

GLY 1156 LEU 1157 0.0117

LEU 1157 MET 1158 0.0093

MET 1158 ARG 1159 0.0110

ARG 1159 SER 1160 0.0063

SER 1160 VAL 1161 0.0111

VAL 1161 ASP 1162 0.0095

ASP 1162 PRO 1163 0.0114

PRO 1163 SER 1164 0.0112

SER 1164 ASN 1165 0.2442

ASN 1165 LEU 1166 0.0083

LEU 1166 TYR 1167 0.0065

TYR 1167 SER 1168 0.0044

SER 1168 PHE 1169 0.0040

PHE 1169 LEU 1170 0.0067

LEU 1170 ARG 1171 0.0083

ARG 1171 ALA 1172 0.0004

ALA 1172 GLN 1173 0.0079

GLN 1173 GLY 1174 0.0055

GLY 1174 ILE 1175 0.0022

ILE 1175 TYR 1176 0.0042

TYR 1176 HIS 1177 0.0021

HIS 1177 GLY 1178 0.0049

GLY 1178 PRO 1179 0.0043

PRO 1179 ILE 1180 0.0050

ILE 1180 PHE 1181 0.0279

PHE 1181 GLN 1182 0.0098

GLN 1182 ASN 1183 0.0064

ASN 1183 LEU 1184 0.0068

LEU 1184 LYS 1185 0.0093

LYS 1185 THR 1186 0.0069

THR 1186 ILE 1187 0.0023

ILE 1187 SER 1188 0.0088

SER 1188 SER 1189 0.0024

SER 1189 ARG 1190 0.0042

ARG 1190 LYS 1191 0.0031

LYS 1191 ASP 1192 0.0085

ASP 1192 HIS 1193 0.0002

HIS 1193 SER 1194 0.0050

SER 1194 GLU 1195 0.0004

GLU 1195 SER 1196 0.0086

SER 1196 SER 1197 -0.0518

SER 1197 PHE 1198 0.0102

PHE 1198 VAL 1199 0.0012

VAL 1199 VAL 1200 0.0098

VAL 1200 ALA 1201 0.0152

ALA 1201 ASN 1202 0.0034

ASN 1202 THR 1203 0.0149

THR 1203 ALA 1204 0.0009

ALA 1204 SER 1205 0.0154

SER 1205 VAL 1206 0.0107

VAL 1206 MET 1207 0.0113

MET 1207 PRO 1208 0.0075

PRO 1208 ASN 1209 0.0043

ASN 1209 GLY 1210 0.0122

GLY 1210 PHE 1211 0.0152

PHE 1211 GLN 1212 0.0085

GLN 1212 SER 1213 0.1217

SER 1213 PRO 1214 0.0237

PRO 1214 HIS 1215 0.0016

HIS 1215 VAL 1216 0.0162

VAL 1216 ILE 1217 0.0161

ILE 1217 HIS 1218 0.0235

HIS 1218 PRO 1219 0.0068

PRO 1219 THR 1220 0.0236

THR 1220 THR 1221 0.0236

THR 1221 LEU 1222 0.0105

LEU 1222 ASP 1223 0.0171

ASP 1223 SER 1224 0.0231

SER 1224 ILE 1225 0.0187

ILE 1225 PHE 1226 0.0105

PHE 1226 GLN 1227 0.0237

GLN 1227 GLY 1228 0.0236

GLY 1228 ALA 1229 -0.0010

ALA 1229 TYR 1230 0.0123

TYR 1230 THR 1231 0.0133

THR 1231 ALA 1232 0.0101

ALA 1232 LEU 1233 0.0051

LEU 1233 PRO 1234 0.0119

PRO 1234 GLY 1235 0.0118

GLY 1235 ALA 1236 0.0067

ALA 1236 GLY 1237 0.0121

GLY 1237 LEU 1238 0.0154

LEU 1238 ASP 1239 0.0001

ASP 1239 GLN 1240 0.0154

GLN 1240 ASN 1241 0.0086

ASN 1241 THR 1242 0.0125

THR 1242 ALA 1243 0.0040

ALA 1243 MET 1244 0.0155

MET 1244 ILE 1245 -0.1293

ILE 1245 PRO 1246 0.0259

PRO 1246 ARG 1247 0.0215

ARG 1247 SER 1248 0.0282

SER 1248 ILE 1249 0.0189

ILE 1249 GLN 1250 0.0305

GLN 1250 GLU 1251 0.0030

GLU 1251 LEU 1252 0.0098

LEU 1252 TYR 1253 0.0069

TYR 1253 LEU 1254 0.0083

LEU 1254 SER 1255 0.0101

SER 1255 SER 1256 0.0067

SER 1256 ALA 1257 0.0287

ALA 1257 LEU 1258 0.0248

LEU 1258 THR 1259 0.0165

THR 1259 SER 1260 0.0305

SER 1260 ASP 1261 0.1154

ASP 1261 VAL 1262 0.0185

VAL 1262 GLY 1263 0.0156

GLY 1263 GLN 1264 0.0185

GLN 1264 CYS 1265 0.0053

CYS 1265 LEU 1266 0.0100

LEU 1266 VAL 1267 0.0057

VAL 1267 SER 1268 0.0058

SER 1268 ASP 1269 0.0074

ASP 1269 THR 1270 0.0068

THR 1270 SER 1271 0.0042

SER 1271 LEU 1272 0.0063

LEU 1272 ILE 1273 0.0152

ILE 1273 ARG 1274 0.0106

ARG 1274 TYR 1275 0.0184

TYR 1275 ASP 1276 0.0076

ASP 1276 GLY 1277 0.1351

GLY 1277 GLN 1278 0.0261

GLN 1278 SER 1279 0.0159

SER 1279 PHE 1280 0.0179

PHE 1280 THR 1281 0.0195

THR 1281 VAL 1282 0.0093

VAL 1282 ASN 1283 0.0128

ASN 1283 VAL 1284 0.0045

VAL 1284 ASP 1285 0.0098

ASP 1285 VAL 1286 0.0071

VAL 1286 SER 1287 0.0086

SER 1287 SER 1288 0.0059

SER 1288 LYS 1289 0.0270

LYS 1289 ALA 1290 0.0040

ALA 1290 ASP 1291 0.0244

ASP 1291 SER 1292 0.0261

SER 1292 GLU 1293 0.0280

GLU 1293 HIS 1294 0.0177

HIS 1294 THR 1295 0.0281

THR 1295 PRO 1296 0.0177

PRO 1296 VAL 1297 0.0211

VAL 1297 LEU 1298 0.0073

LEU 1298 GLU 1299 0.0057

GLU 1299 ILE 1300 0.0075

ILE 1300 LYS 1301 0.0084

LYS 1301 GLY 1302 0.0061

GLY 1302 LEU 1303 0.0258

LEU 1303 ARG 1304 0.0061

ARG 1304 ASN 1305 0.0278

ASN 1305 GLN 1306 0.0097

GLN 1306 SER 1307 0.0230

SER 1307 VAL 1308 0.0273

VAL 1308 GLY 1309 0.2257

GLY 1309 GLN 1310 0.0367

GLN 1310 MET 1311 0.0040

MET 1311 ALA 1312 0.0374

ALA 1312 PRO 1313 0.0389

PRO 1313 GLN 1314 0.0010

GLN 1314 PRO 1315 0.0359

PRO 1315 GLY 1316 0.0384

GLY 1316 ASP 1317 0.0184

ASP 1317 SER 1318 0.0185

SER 1318 SER 1319 0.0220

SER 1319 ASN 1320 0.0386

ASN 1320 ASN 1321 0.0170

ASN 1321 ASP 1322 0.0373

ASP 1322 LEU 1323 0.0291

LEU 1323 CYS 1324 0.0333

CYS 1324 PHE 1325 -0.0073

PHE 1325 LYS 1326 0.0086

LYS 1326 LEU 1327 0.0109

LEU 1327 ASP 1328 0.0012

ASP 1328 TRP 1329 0.0083

TRP 1329 ALA 1330 0.0018

ALA 1330 PRO 1331 0.0047

PRO 1331 ASP 1332 0.0170

ASP 1332 ILE 1333 0.0066

ILE 1333 SER 1334 0.0162

SER 1334 SER 1335 0.0169

SER 1335 VAL 1336 0.0148

VAL 1336 LYS 1337 0.0035

LYS 1337 GLN 1338 0.0086

GLN 1338 GLU 1339 0.0162

GLU 1339 ARG 1340 0.0026

ARG 1340 LEU 1341 -0.2714

LEU 1341 LYS 1342 0.0514

LYS 1342 GLU 1343 0.0089

GLU 1343 LYS 1344 0.0545

LYS 1344 PHE 1345 0.0172

PHE 1345 GLY 1346 0.0466

GLY 1346 PHE 1347 0.0581

PHE 1347 PRO 1348 0.0583

PRO 1348 LEU 1349 0.0292

LEU 1349 ASP 1350 0.0564

ASP 1350 PRO 1351 0.0553

PRO 1351 THR 1352 0.0556

THR 1352 GLU 1353 0.0356

GLU 1353 ALA 1354 0.0489

ALA 1354 ASP 1355 0.0566

ASP 1355 ILE 1356 0.0500

ILE 1356 ILE 1357 0.2287

ILE 1357 MET 1358 0.1133

MET 1358 GLY 1359 0.1242

GLY 1359 LEU 1360 0.1322

LEU 1360 ARG 1361 0.1165

ARG 1361 GLN 1362 0.1141

GLN 1362 ALA 1363 0.1335

ALA 1363 CYS 1364 0.1267

CYS 1364 ILE 1365 0.1032

ILE 1365 HIS 1366 0.1237

HIS 1366 PHE 1367 0.1340

PHE 1367 ILE 1368 0.1251

ILE 1368 HIS 1369 0.1088

HIS 1369 ARG 1370 0.1248

ARG 1370 SER 1371 0.1345

SER 1371 LEU 1372 0.1193

LEU 1372 GLN 1373 0.1210

GLN 1373 SER 1374 0.1454

SER 1374 LEU 1375 0.1499

LEU 1375 THR 1376 0.0077

THR 1376 ALA 1377 0.1321

ALA 1377 PRO 1378 0.1502

PRO 1378 ASP 1379 0.0179

ASP 1379 ARG 1380 0.1407

ARG 1380 ASP 1381 0.1138

ASP 1381 GLN 1382 0.1266

GLN 1382 LEU 1383 0.0226

LEU 1383 ASP 1384 0.1082

ASP 1384 TRP 1385 0.1347

TRP 1385 HIS 1386 0.0407

HIS 1386 GLN 1387 0.1241

GLN 1387 LYS 1388 0.1163

LYS 1388 ARG 1389 -0.0044

ARG 1389 PHE 1390 0.1343

PHE 1390 TYR 1391 0.0536

TYR 1391 ASP 1392 0.1531

ASP 1392 TRP 1393 0.0141

TRP 1393 MET 1394 0.1457

MET 1394 VAL 1395 0.0935

VAL 1395 LEU 1396 0.0838

LEU 1396 GLN 1397 0.0984

GLN 1397 ILE 1398 0.0897

ILE 1398 GLN 1399 0.1515

GLN 1399 LEU 1400 0.0046

LEU 1400 ALA 1401 0.1541

ALA 1401 GLU 1402 0.0775

GLU 1402 GLU 1403 0.1243

GLU 1403 ASP 1404 0.0500

ASP 1404 ARG 1405 0.1787

ARG 1405 LEU 1406 0.1365

LEU 1406 ALA 1407 0.1145

ALA 1407 PRO 1408 0.1539

PRO 1408 ASN 1409 0.0654

ASN 1409 SER 1410 0.1450

SER 1410 SER 1411 0.0164

SER 1411 ALA 1412 0.1499

ALA 1412 TRP 1413 0.1485

TRP 1413 LEU 1414 0.0085

LEU 1414 GLN 1415 0.1490

GLN 1415 CYS 1416 0.1037

CYS 1416 SER 1417 0.1438

SER 1417 SER 1418 0.1543

SER 1418 SER 1419 0.0782

SER 1419 ASP 1420 0.1040

ASP 1420 GLU 1421 0.2167

GLU 1421 GLN 1422 0.1368

GLN 1422 LYS 1423 0.0306

LYS 1423 LEU 1424 0.1422

LEU 1424 LEU 1425 0.1367

LEU 1425 GLU 1426 0.0971

GLU 1426 ASN 1427 0.0669

ASN 1427 VAL 1428 0.1407

VAL 1428 ARG 1429 0.1442

ARG 1429 ALA 1430 0.0399

ALA 1430 SER 1431 0.1154

SER 1431 SER 1432 0.1445

SER 1432 VAL 1433 0.1308

VAL 1433 ASN 1434 0.1028

ASN 1434 GLY 1435 0.1213

GLY 1435 GLN 1436 0.1423

GLN 1436 MET 1437 0.0990

MET 1437 VAL 1438 0.0945

VAL 1438 VAL 1439 0.1192

VAL 1439 HIS 1440 0.1333

HIS 1440 VAL 1441 0.1087

VAL 1441 GLY 1442 0.1105

GLY 1442 LYS 1443 0.1113

LYS 1443 SER 1444 0.1182

SER 1444 MET 1445 0.1301

MET 1445 LEU 1446 0.0030

LEU 1446 ALA 1447 0.1352

ALA 1447 ILE 1448 0.1011

ILE 1448 LEU 1449 0.0835

LEU 1449 ARG 1450 0.0677

ARG 1450 HIS 1451 0.1063

HIS 1451 GLU 1452 0.1339

GLU 1452 ILE 1453 0.0540

ILE 1453 ALA 1454 0.0637

ALA 1454 PRO 1455 0.0710

PRO 1455 LEU 1456 0.0296

LEU 1456 GLU 1457 0.0957

GLU 1457 LEU 1458 0.0942

LEU 1458 MET 1459 0.0414

MET 1459 LEU 1460 0.0648

LEU 1460 GLN 1461 0.0938

GLN 1461 ASP 1462 0.0316

ASP 1462 LYS 1463 0.0771

LYS 1463 LEU 1464 0.0817

LEU 1464 LEU 1465 0.0955

LEU 1465 TYR 1466 0.0062

TYR 1466 ARG 1467 0.0921

ARG 1467 TYR 1468 0.0655

TYR 1468 TYR 1469 0.1531

TYR 1469 THR 1470 0.0182

THR 1470 ASP 1471 0.0580

ASP 1471 ALA 1472 0.0286

ALA 1472 ILE 1473 0.0577

ILE 1473 LYS 1474 0.0488

LYS 1474 TRP 1475 0.0548

TRP 1475 ASP 1476 0.0081

ASP 1476 ARG 1477 0.0572

ARG 1477 SER 1478 0.0539

SER 1478 TYR 1479 0.0444

TYR 1479 GLN 1480 0.0204

GLN 1480 GLN 1481 0.0587

GLN 1481 ILE 1482 0.0591

ILE 1482 ASP 1483 0.0215

ASP 1483 GLN 1484 0.0430

GLN 1484 LEU 1485 0.0407

LEU 1485 VAL 1486 0.0109

VAL 1486 LYS 1487 0.0147

LYS 1487 LEU 1488 0.0199

LEU 1488 HIS 1489 0.0187

HIS 1489 ALA 1490 0.0103

ALA 1490 HIS 1491 0.0172

HIS 1491 LYS 1492 0.0197

LYS 1492 CYS 1493 0.0182

CYS 1493 PRO 1494 0.0170

PRO 1494 THR 1495 0.0176

THR 1495 ALA 1496 0.0041

ALA 1496 LYS 1497 0.0194

LYS 1497 ILE 1498 0.0028

ILE 1498 ILE 1499 0.0112

ILE 1499 GLU 1500 0.0054

GLU 1500 ILE 1501 0.0410

ILE 1501 GLY 1502 0.0341

GLY 1502 ALA 1503 0.0231

ALA 1503 GLY 1504 0.0321

GLY 1504 THR 1505 0.0416

THR 1505 GLY 1506 0.0175

GLY 1506 GLY 1507 0.0455

GLY 1507 CYS 1508 0.0424

CYS 1508 THR 1509 0.0250

THR 1509 ARG 1510 0.0372

ARG 1510 ALA 1511 0.0477

ALA 1511 VAL 1512 0.0450

VAL 1512 LEU 1513 0.0259

LEU 1513 ASP 1514 0.0421

ASP 1514 ALA 1515 0.0476

ALA 1515 LEU 1516 0.0394

LEU 1516 SER 1517 -0.0447

SER 1517 ASN 1518 0.0176

ASN 1518 GLN 1519 0.0207

GLN 1519 GLY 1520 0.0239

GLY 1520 ILE 1521 0.0222

ILE 1521 ALA 1522 0.0144

ALA 1522 ARG 1523 0.0235

ARG 1523 CYS 1524 0.0226

CYS 1524 ALA 1525 0.0184

ALA 1525 GLN 1526 0.0144

GLN 1526 TYR 1527 0.0058

TYR 1527 ASP 1528 0.0170

ASP 1528 PHE 1529 0.0154

PHE 1529 THR 1530 0.0111

THR 1530 ASP 1531 0.0074

ASP 1531 VAL 1532 0.0158

VAL 1532 SER 1533 0.1065

SER 1533 SER 1534 0.0142

SER 1534 GLY 1535 0.0385

GLY 1535 PHE 1536 0.0321

PHE 1536 PHE 1537 0.0111

PHE 1537 GLU 1538 0.0412

GLU 1538 ALA 1539 0.0442

ALA 1539 ALA 1540 0.0384

ALA 1540 GLN 1541 0.0156

GLN 1541 GLN 1542 0.0448

GLN 1542 LYS 1543 0.0441

LYS 1543 PHE 1544 0.0281

PHE 1544 ALA 1545 0.0228

ALA 1545 ALA 1546 0.0261

ALA 1546 PHE 1547 0.0444

PHE 1547 ASP 1548 0.0456

ASP 1548 ASP 1549 0.1119

ASP 1549 VAL 1550 0.0346

VAL 1550 ILE 1551 0.0042

ILE 1551 ARG 1552 0.0332

ARG 1552 PHE 1553 0.0069

PHE 1553 GLN 1554 0.0257

GLN 1554 LYS 1555 0.0008

LYS 1555 LEU 1556 0.0405

LEU 1556 ASP 1557 0.0055

ASP 1557 ILE 1558 0.0454

ILE 1558 GLU 1559 0.0101

GLU 1559 LYS 1560 0.0407

LYS 1560 ASP 1561 0.0255

ASP 1561 ILE 1562 0.0067

ILE 1562 GLU 1563 0.0339

GLU 1563 MET 1564 0.0276

MET 1564 GLN 1565 0.0648

GLN 1565 GLY 1566 0.0003

GLY 1566 PHE 1567 0.0369

PHE 1567 GLU 1568 0.0230

GLU 1568 CYS 1569 0.0349

CYS 1569 GLY 1570 0.0280

GLY 1570 SER 1571 0.0266

SER 1571 TYR 1572 0.0359

TYR 1572 ASP 1573 0.0344

ASP 1573 LEU 1574 0.0188

LEU 1574 VAL 1575 0.0048

VAL 1575 ILE 1576 0.0300

ILE 1576 ALA 1577 0.0004

ALA 1577 SER 1578 0.0310

SER 1578 GLN 1579 0.0002

GLN 1579 VAL 1580 0.0388

VAL 1580 LEU 1581 0.0870

LEU 1581 HIS 1582 0.0092

HIS 1582 ALA 1583 0.0320

ALA 1583 THR 1584 0.0373

THR 1584 GLY 1585 0.0267

GLY 1585 LYS 1586 0.0256

LYS 1586 MET 1587 0.0188

MET 1587 GLU 1588 0.0267

GLU 1588 HIS 1589 0.0387

HIS 1589 THR 1590 0.0372

THR 1590 MET 1591 0.0194

MET 1591 ALA 1592 0.0331

ALA 1592 ASN 1593 0.0384

ASN 1593 VAL 1594 0.0332

VAL 1594 ARG 1595 0.0221

ARG 1595 LYS 1596 0.0355

LYS 1596 LEU 1597 -0.1520

LEU 1597 LEU 1598 0.0154

LEU 1598 LYS 1599 0.0089

LYS 1599 PRO 1600 0.0280

PRO 1600 GLY 1601 0.0264

GLY 1601 GLY 1602 0.0251

GLY 1602 LYS 1603 0.0231

LYS 1603 LEU 1604 0.0033

LEU 1604 LEU 1605 0.0277

LEU 1605 LEU 1606 0.0025

LEU 1606 VAL 1607 0.0229

VAL 1607 GLU 1608 0.0027

GLU 1608 THR 1609 0.0113

THR 1609 THR 1610 0.0285

THR 1610 ARG 1611 0.0160

ARG 1611 ASP 1612 0.0143

ASP 1612 GLU 1613 -0.0894

GLU 1613 MET 1614 0.0228

MET 1614 ASP 1615 0.1009

ASP 1615 LEU 1616 0.0963

LEU 1616 GLN 1617 0.0395

GLN 1617 LEU 1618 0.0676

LEU 1618 VAL 1619 0.0896

VAL 1619 PHE 1620 0.1046

PHE 1620 GLY 1621 0.0476

GLY 1621 LEU 1622 0.0686

LEU 1622 LEU 1623 0.0883

LEU 1623 PRO 1624 0.0956

PRO 1624 GLY 1625 0.0126

GLY 1625 TRP 1626 0.1037

TRP 1626 TRP 1627 0.0595

TRP 1627 LEU 1628 0.1004

LEU 1628 SER 1629 0.2484

SER 1629 SER 1630 0.0560

SER 1630 GLU 1631 0.0421

GLU 1631 GLU 1632 0.0481

GLU 1632 GLU 1633 0.0382

GLU 1633 ARG 1634 0.0615

ARG 1634 GLN 1635 0.0005

GLN 1635 MET 1636 0.0617

MET 1636 SER 1637 0.0214

SER 1637 PRO 1638 0.0428

PRO 1638 SER 1639 0.0225

SER 1639 LEU 1640 0.0375

LEU 1640 SER 1641 0.0491

SER 1641 THR 1642 -0.0000

THR 1642 ASN 1643 0.0623

ASN 1643 SER 1644 0.0422

SER 1644 TRP 1645 -0.0061

TRP 1645 GLU 1646 0.0134

GLU 1646 LYS 1647 0.0232

LYS 1647 VAL 1648 0.0280

VAL 1648 LEU 1649 0.0037

LEU 1649 LYS 1650 0.0255

LYS 1650 LYS 1651 0.0184

LYS 1651 THR 1652 0.0283

THR 1652 GLY 1653 0.0002

GLY 1653 PHE 1654 0.0269

PHE 1654 ASP 1655 0.0223

ASP 1655 GLY 1656 0.0147

GLY 1656 LEU 1657 0.0294

LEU 1657 ASP 1658 0.0048

ASP 1658 ILE 1659 0.0256

ILE 1659 GLU 1660 0.0066

GLU 1660 LEU 1661 -0.0015

LEU 1661 ARG 1662 0.0278

ARG 1662 ASP 1663 0.0489

ASP 1663 CYS 1664 0.0482

CYS 1664 ASP 1665 0.0466

ASP 1665 SER 1666 0.0114

SER 1666 ASP 1667 0.0239

ASP 1667 GLU 1668 0.0291

GLU 1668 PHE 1669 0.0451

PHE 1669 TYR 1670 0.0416

TYR 1670 SER 1671 0.0349

SER 1671 PHE 1672 0.0318

PHE 1672 SER 1673 0.0332

SER 1673 VAL 1674 0.0241

VAL 1674 MET 1675 0.0490

MET 1675 MET 1676 0.0316

MET 1676 ALA 1677 0.1765

ALA 1677 THR 1678 0.1217

THR 1678 ALA 1679 0.0840

ALA 1679 SER 1680 0.1027

SER 1680 SER 1681 0.1061

SER 1681 THR 1682 0.1028

THR 1682 ILE 1683 0.0750

ILE 1683 ALA 1684 0.1201

ALA 1684 SER 1685 0.1223

SER 1685 SER 1686 0.0542

SER 1686 SER 1687 0.1222

SER 1687 MET 1688 0.0040

MET 1688 ALA 1689 0.1015

ALA 1689 PHE 1690 0.0740

PHE 1690 ALA 1691 0.0515

ALA 1691 ILE 1692 0.0902

ILE 1692 VAL 1693 0.2220

VAL 1693 TYR 1694 0.0644

TYR 1694 GLY 1695 0.0039

GLY 1695 GLU 1696 0.0553

GLU 1696 VAL 1697 0.0632

VAL 1697 PRO 1698 0.0235

PRO 1698 LEU 1699 0.0316

LEU 1699 PRO 1700 0.0686

PRO 1700 ASP 1701 0.0549

ASP 1701 GLN 1702 0.0405

GLN 1702 PHE 1703 0.0881

PHE 1703 LEU 1704 0.0911

LEU 1704 ASP 1705 0.0217

ASP 1705 ASP 1706 0.0751

ASP 1706 MET 1707 0.0764

MET 1707 LYS 1708 0.0839

LYS 1708 THR 1709 0.0372

THR 1709 ALA 1710 0.0865

ALA 1710 ILE 1711 0.0809

ILE 1711 SER 1712 0.0473

SER 1712 SER 1713 0.0470

SER 1713 SER 1714 0.0800

SER 1714 ALA 1715 0.0837

ALA 1715 VAL 1716 0.0727

VAL 1716 SER 1717 0.0381

SER 1717 ASP 1718 0.0685

ASP 1718 PRO 1719 0.0093

PRO 1719 VAL 1720 0.0393

VAL 1720 VAL 1721 0.0485

VAL 1721 GLY 1722 0.0084

GLY 1722 HIS 1723 0.0058

HIS 1723 LEU 1724 0.0715

LEU 1724 ASP 1725 0.0831

ASP 1725 SER 1726 0.0539

SER 1726 ILE 1727 0.0280

ILE 1727 ASP 1728 0.0859

ASP 1728 ALA 1729 0.0883

ALA 1729 THR 1730 0.0916

THR 1730 GLY 1731 0.0221

GLY 1731 LYS 1732 0.0935

LYS 1732 PHE 1733 0.0957

PHE 1733 CYS 1734 0.0513

CYS 1734 ILE 1735 0.0969

ILE 1735 PHE 1736 0.0079

PHE 1736 ILE 1737 0.0959

ILE 1737 GLU 1738 0.0103

GLU 1738 ASP 1739 0.0849

ASP 1739 PRO 1740 0.0944

PRO 1740 GLU 1741 0.0675

GLU 1741 THR 1742 0.0828

THR 1742 ASP 1743 0.0986

ASP 1743 ILE 1744 0.0961

ILE 1744 LEU 1745 0.0978

LEU 1745 SER 1746 0.0680

SER 1746 SER 1747 0.0476

SER 1747 PRO 1748 0.0928

PRO 1748 ASP 1749 0.0706

ASP 1749 GLU 1750 0.0980

GLU 1750 LYS 1751 0.0566

LYS 1751 SER 1752 0.0495

SER 1752 TYR 1753 0.0982

TYR 1753 ALA 1754 0.0997

ALA 1754 SER 1755 0.0350

SER 1755 ILE 1756 0.0841

ILE 1756 GLN 1757 0.1202

GLN 1757 LYS 1758 0.0651

LYS 1758 LEU 1759 0.0383

LEU 1759 VAL 1760 0.0853

VAL 1760 THR 1761 0.0851

THR 1761 ARG 1762 0.0554

ARG 1762 CYS 1763 0.0400

CYS 1763 LYS 1764 0.0273

LYS 1764 GLY 1765 0.0869

GLY 1765 LEU 1766 0.0712

LEU 1766 ILE 1767 0.0831

ILE 1767 TRP 1768 0.0226

TRP 1768 VAL 1769 0.0843

VAL 1769 SER 1770 0.0552

SER 1770 ARG 1771 0.0865

ARG 1771 GLY 1772 0.0790

GLY 1772 GLY 1773 0.1147

GLY 1773 ALA 1774 0.0417

ALA 1774 MET 1775 0.0603

MET 1775 HIS 1776 0.0556

HIS 1776 GLY 1777 0.0244

GLY 1777 THR 1778 0.0771

THR 1778 ARG 1779 0.0529

ARG 1779 PRO 1780 0.0595

PRO 1780 ASN 1781 0.0673

ASN 1781 SER 1782 0.0119

SER 1782 SER 1783 0.0769

SER 1783 LEU 1784 0.0405

LEU 1784 LYS 1785 0.0435

LYS 1785 THR 1786 0.0491

THR 1786 GLY 1787 0.0385

GLY 1787 LEU 1788 0.0743

LEU 1788 LEU 1789 -0.0179

LEU 1789 ARG 1790 0.0799

ARG 1790 THR 1791 0.0410

THR 1791 LEU 1792 0.0727

LEU 1792 ARG 1793 0.0168

ARG 1793 LEU 1794 0.0642

LEU 1794 GLU 1795 0.0568

GLU 1795 TYR 1796 0.0359

TYR 1796 THR 1797 0.0273

THR 1797 GLU 1798 0.0614

GLU 1798 LYS 1799 0.0790

LYS 1799 ARG 1800 0.0628

ARG 1800 PHE 1801 0.0475

PHE 1801 ILE 1802 0.0665

ILE 1802 SER 1803 0.0667

SER 1803 LEU 1804 0.0605

LEU 1804 ASP 1805 0.0394

ASP 1805 LEU 1806 0.0792

LEU 1806 ASP 1807 0.0982

ASP 1807 SER 1808 0.0266

SER 1808 ALA 1809 0.0817

ALA 1809 ARG 1810 0.0585

ARG 1810 PRO 1811 0.0959

PRO 1811 GLN 1812 0.0829

GLN 1812 TRP 1813 0.0524

TRP 1813 ASN 1814 0.0192

ASN 1814 HIS 1815 0.0171

HIS 1815 ASP 1816 0.0981

ASP 1816 SER 1817 0.0392

SER 1817 ILE 1818 0.0740

ILE 1818 THR 1819 0.0432

THR 1819 THR 1820 0.0646

THR 1820 ILE 1821 0.0390

ILE 1821 ASN 1822 0.0148

ASN 1822 GLU 1823 0.0511

GLU 1823 VAL 1824 0.0130

VAL 1824 LEU 1825 0.0530

LEU 1825 CYS 1826 0.0085

CYS 1826 GLY 1827 0.0470

GLY 1827 ALA 1828 0.0266

ALA 1828 LEU 1829 0.0297

LEU 1829 ALA 1830 0.0232

ALA 1830 GLN 1831 0.0418

GLN 1831 ASN 1832 0.0483

ASN 1832 ALA 1833 0.0360

ALA 1833 ASP 1834 0.0527

ASP 1834 SER 1835 0.0487

SER 1835 SER 1836 0.0127

SER 1836 ILE 1837 -0.2652

ILE 1837 LYS 1838 0.0514

LYS 1838 ASP 1839 0.0485

ASP 1839 SER 1840 0.0199

SER 1840 GLU 1841 0.0510

GLU 1841 PHE 1842 0.0373

PHE 1842 ALA 1843 0.0537

ALA 1843 GLU 1844 0.0371

GLU 1844 GLN 1845 0.0541

GLN 1845 ASP 1846 0.0329

ASP 1846 GLY 1847 0.0435

GLY 1847 GLN 1848 0.0535

GLN 1848 LEU 1849 0.0447

LEU 1849 PHE 1850 0.0410

PHE 1850 VAL 1851 0.0487

VAL 1851 PRO 1852 0.0258

PRO 1852 ARG 1853 -0.1242

ARG 1853 ILE 1854 0.0279

ILE 1854 SER 1855 0.0047

SER 1855 CYS 1856 0.0241

CYS 1856 ASP 1857 0.0252

ASP 1857 ILE 1858 0.0071

ILE 1858 ALA 1859 0.0242

ALA 1859 ARG 1860 0.0105

ARG 1860 ASN 1861 0.0278

ASN 1861 GLU 1862 0.0017

GLU 1862 ASP 1863 0.0269

ASP 1863 LEU 1864 0.0106

LEU 1864 SER 1865 0.0208

SER 1865 SER 1866 0.0098

SER 1866 ASP 1867 0.0262

ASP 1867 SER 1868 0.0263

SER 1868 ASN 1869 0.0237

ASN 1869 SER 1870 0.0528

SER 1870 PRO 1871 0.0062

PRO 1871 ALA 1872 0.0616

ALA 1872 GLN 1873 0.0417

GLN 1873 MET 1874 0.0393

MET 1874 GLU 1875 0.0535

GLU 1875 PRO 1876 0.0605

PRO 1876 PHE 1877 0.0431

PHE 1877 HIS 1878 0.0617

HIS 1878 GLN 1879 0.0458

GLN 1879 PRO 1880 0.0483

PRO 1880 GLY 1881 0.0031

GLY 1881 LYS 1882 0.0621

LYS 1882 LEU 1883 0.0573

LEU 1883 LEU 1884 0.0458

LEU 1884 GLN 1885 0.1466

GLN 1885 MET 1886 0.0579

MET 1886 GLY 1887 0.0487

GLY 1887 ILE 1888 0.0600

ILE 1888 LYS 1889 0.0608

LYS 1889 THR 1890 0.0577

THR 1890 PRO 1891 0.0439

PRO 1891 GLY 1892 0.0493

GLY 1892 LEU 1893 0.0099

LEU 1893 ILE 1894 0.0550

ILE 1894 ASP 1895 0.0212

ASP 1895 THR 1896 0.0402

THR 1896 LEU 1897 0.0603

LEU 1897 GLN 1898 0.0607

GLN 1898 PHE 1899 0.0586

PHE 1899 SER 1900 0.0469

SER 1900 LYS 1901 0.0585

LYS 1901 THR 1902 0.0176

THR 1902 ASP 1903 0.0606

ASP 1903 ALA 1904 0.0762

ALA 1904 THR 1905 0.0166

THR 1905 ASP 1906 0.0752

ASP 1906 ASN 1907 0.0364

ASN 1907 LEU 1908 0.0731

LEU 1908 PRO 1909 0.0253

PRO 1909 ASN 1910 0.0759

ASN 1910 ASP 1911 0.0755

ASP 1911 TYR 1912 0.0284

TYR 1912 ILE 1913 0.0030

ILE 1913 GLU 1914 0.0419

GLU 1914 ILE 1915 0.0208

ILE 1915 GLU 1916 0.0218

GLU 1916 PRO 1917 0.0714

PRO 1917 LYS 1918 0.0102

LYS 1918 ALA 1919 0.0695

ALA 1919 PHE 1920 0.0286

PHE 1920 GLY 1921 0.0676

GLY 1921 LEU 1922 0.0711

LEU 1922 ASN 1923 0.0277

ASN 1923 PHE 1924 0.0660

PHE 1924 ARG 1925 0.0248

ARG 1925 ASP 1926 0.0537

ASP 1926 VAL 1927 0.0675

VAL 1927 MET 1928 0.0104

MET 1928 VAL 1929 0.0675

VAL 1929 ALA 1930 0.0311

ALA 1930 MET 1931 0.0689

MET 1931 GLY 1932 0.0061

GLY 1932 GLN 1933 0.0193

GLN 1933 LEU 1934 0.0595

LEU 1934 GLU 1935 0.0318

GLU 1935 GLU 1936 0.0600

GLU 1936 SER 1937 0.0361

SER 1937 ILE 1938 0.0572

ILE 1938 MET 1939 0.0065

MET 1939 GLY 1940 0.0426

GLY 1940 PHE 1941 0.0643

PHE 1941 GLU 1942 0.0314

GLU 1942 CYS 1943 0.0262

CYS 1943 ALA 1944 0.0389

ALA 1944 GLY 1945 0.0669

GLY 1945 VAL 1946 0.0720

VAL 1946 VAL 1947 0.0295

VAL 1947 ARG 1948 0.0722

ARG 1948 ARG 1949 0.0533

ARG 1949 VAL 1950 0.0422

VAL 1950 GLY 1951 0.0026

GLY 1951 PRO 1952 0.0669

PRO 1952 SER 1953 0.0687

SER 1953 SER 1954 0.0265

SER 1954 ALA 1955 0.0610

ALA 1955 GLY 1956 0.0619

GLY 1956 HIS 1957 0.0710

HIS 1957 ASN 1958 0.0080

ASN 1958 ILE 1959 0.0753

ILE 1959 LYS 1960 0.0615

LYS 1960 VAL 1961 0.0665

VAL 1961 GLY 1962 0.0112

GLY 1962 ASP 1963 0.0786

ASP 1963 ARG 1964 0.0657

ARG 1964 VAL 1965 0.0700

VAL 1965 CYS 1966 0.0670

CYS 1966 ALA 1967 0.0202

ALA 1967 LEU 1968 0.0452

LEU 1968 LEU 1969 0.0671

LEU 1969 GLY 1970 0.0256

GLY 1970 GLY 1971 0.0431

GLY 1971 GLN 1972 0.0439

GLN 1972 TRP 1973 0.0017

TRP 1973 THR 1974 0.0694

THR 1974 ASN 1975 0.0385

ASN 1975 THR 1976 0.0345

THR 1976 VAL 1977 0.0375

VAL 1977 ARG 1978 0.0142

ARG 1978 VAL 1979 0.0557

VAL 1979 HIS 1980 0.0327

HIS 1980 TRP 1981 0.0761

TRP 1981 HIS 1982 0.0701

HIS 1982 SER 1983 0.0417

SER 1983 VAL 1984 0.0317

VAL 1984 ALA 1985 0.0510

ALA 1985 PRO 1986 0.0304

PRO 1986 ILE 1987 0.0186

ILE 1987 PRO 1988 0.0396

PRO 1988 GLN 1989 0.0407

GLN 1989 ALA 1990 0.0373

ALA 1990 MET 1991 0.0615

MET 1991 ASP 1992 0.0680

ASP 1992 TRP 1993 0.0479

TRP 1993 GLU 1994 0.0736

GLU 1994 THR 1995 0.0716

THR 1995 ALA 1996 0.0306

ALA 1996 ALA 1997 0.0401

ALA 1997 SER 1998 0.0425

SER 1998 ILE 1999 0.0229

ILE 1999 PRO 2000 0.0083

PRO 2000 ILE 2001 0.0368

ILE 2001 VAL 2002 0.0341

VAL 2002 PHE 2003 0.0410

PHE 2003 VAL 2004 0.0073

VAL 2004 THR 2005 0.0410

THR 2005 ALA 2006 0.0376

ALA 2006 TYR 2007 0.0359

TYR 2007 ILE 2008 0.0079

ILE 2008 SER 2009 0.0427

SER 2009 LEU 2010 0.0376

LEU 2010 VAL 2011 0.0405

VAL 2011 LYS 2012 0.0125

LYS 2012 ILE 2013 0.1762

ILE 2013 ALA 2014 0.0248

ALA 2014 ARG 2015 0.0276

ARG 2015 MET 2016 0.0131

MET 2016 GLN 2017 0.0268

GLN 2017 ALA 2018 0.0105

ALA 2018 GLY 2019 0.0275

GLY 2019 GLU 2020 0.0203

GLU 2020 THR 2021 0.0240

THR 2021 VAL 2022 0.0271

VAL 2022 LEU 2023 0.0267

LEU 2023 ILE 2024 0.0217

ILE 2024 HIS 2025 0.0272

HIS 2025 ALA 2026 0.0113

ALA 2026 ALA 2027 0.0228

ALA 2027 SER 2028 0.0060

SER 2028 GLY 2029 -0.0076

GLY 2029 GLY 2030 0.0431

GLY 2030 VAL 2031 0.0063

VAL 2031 GLY 2032 0.0417

GLY 2032 GLN 2033 0.0145

GLN 2033 ALA 2034 0.0340

ALA 2034 ALA 2035 0.0213

ALA 2035 ILE 2036 0.0237

ILE 2036 ILE 2037 0.0368

ILE 2037 LEU 2038 0.0102

LEU 2038 ALA 2039 0.0402

ALA 2039 LYS 2040 0.0141

LYS 2040 HIS 2041 0.0422

HIS 2041 VAL 2042 0.0068

VAL 2042 GLY 2043 0.0375

GLY 2043 ALA 2044 0.0349

ALA 2044 GLU 2045 0.1213

GLU 2045 ILE 2046 0.0346

ILE 2046 PHE 2047 0.0380

PHE 2047 ALA 2048 0.0306

ALA 2048 THR 2049 0.0384

THR 2049 VAL 2050 0.0149

VAL 2050 GLY 2051 0.0367

GLY 2051 THR 2052 0.0068

THR 2052 ASP 2053 0.0256

ASP 2053 GLU 2054 0.0244

GLU 2054 LYS 2055 0.0144

LYS 2055 ARG 2056 0.0364

ARG 2056 ASP 2057 0.0060

ASP 2057 LEU 2058 0.0384

LEU 2058 LEU 2059 0.0126

LEU 2059 ILE 2060 0.0322

ILE 2060 LYS 2061 0.0006

LYS 2061 GLU 2062 0.0361

GLU 2062 TYR 2063 0.0064

TYR 2063 LYS 2064 0.0386

LYS 2064 ILE 2065 0.0107

ILE 2065 PRO 2066 0.0387

PRO 2066 ASP 2067 0.0382

ASP 2067 ASP 2068 0.0102

ASP 2068 HIS 2069 0.0312

HIS 2069 ILE 2070 0.0353

ILE 2070 PHE 2071 0.0293

PHE 2071 SER 2072 0.0388

SER 2072 SER 2073 0.0287

SER 2073 ARG 2074 0.0386

ARG 2074 ASN 2075 0.0243

ASN 2075 ALA 2076 0.0137

ALA 2076 LEU 2077 -0.0419

LEU 2077 PHE 2078 0.0287

PHE 2078 ALA 2079 0.0013

ALA 2079 LYS 2080 0.0293

LYS 2080 SER 2081 0.0081

SER 2081 ILE 2082 0.0257

ILE 2082 ARG 2083 0.0086

ARG 2083 GLN 2084 0.0211

GLN 2084 ARG 2085 0.0205

ARG 2085 THR 2086 0.0106

THR 2086 ASN 2087 0.0241

ASN 2087 GLY 2088 0.0167

GLY 2088 LYS 2089 0.0271

LYS 2089 GLY 2090 0.0240

GLY 2090 VAL 2091 0.0260

VAL 2091 ASP 2092 0.0219

ASP 2092 VAL 2093 0.0299

VAL 2093 VAL 2094 0.0210

VAL 2094 LEU 2095 0.0182

LEU 2095 ASN 2096 0.0222

ASN 2096 CYS 2097 0.0199

CYS 2097 LEU 2098 0.0225

LEU 2098 ALA 2099 0.0121

ALA 2099 GLY 2100 0.0145

GLY 2100 GLY 2101 0.0227

GLY 2101 LEU 2102 0.0108

LEU 2102 LEU 2103 0.0145

LEU 2103 GLN 2104 0.0120

GLN 2104 GLU 2105 0.0123

GLU 2105 SER 2106 0.0207

SER 2106 PHE 2107 0.0017

PHE 2107 ASP 2108 0.0222

ASP 2108 CYS 2109 0.0279

CYS 2109 LEU 2110 0.0121

LEU 2110 ALA 2111 0.0115

ALA 2111 ASP 2112 0.0021

ASP 2112 PHE 2113 0.0141

PHE 2113 GLY 2114 0.0030

GLY 2114 ARG 2115 0.0123

ARG 2115 PHE 2116 0.0121

PHE 2116 ILE 2117 0.0091

ILE 2117 GLU 2118 0.0137

GLU 2118 ILE 2119 0.0052

ILE 2119 GLY 2120 0.0140

GLY 2120 LYS 2121 0.0119

LYS 2121 ARG 2122 0.0138

ARG 2122 ASP 2123 0.0039

ASP 2123 ILE 2124 0.0114

ILE 2124 GLU 2125 0.0408

GLU 2125 LEU 2126 0.0057

LEU 2126 ASN 2127 0.0051

ASN 2127 HIS 2128 0.0064

HIS 2128 CYS 2129 0.0058

CYS 2129 LEU 2130 0.0046

LEU 2130 ASN 2131 0.0066

ASN 2131 MET 2132 0.0057

MET 2132 GLY 2133 0.0063

GLY 2133 MET 2134 0.0013

MET 2134 PHE 2135 0.0056

PHE 2135 ALA 2136 0.0064

ALA 2136 ARG 2137 0.0002

ARG 2137 SER 2138 0.0066

SER 2138 ALA 2139 0.0048

ALA 2139 THR 2140 0.0069

THR 2140 PHE 2141 -0.0913

PHE 2141 THR 2142 0.0393

THR 2142 ALA 2143 0.0386

ALA 2143 VAL 2144 0.0357

VAL 2144 ASP 2145 0.0390

ASP 2145 LEU 2146 0.0366

LEU 2146 ILE 2147 0.0299

ILE 2147 ALA 2148 0.0104

ALA 2148 ILE 2149 0.0375

ILE 2149 GLY 2150 0.0375

GLY 2150 ARG 2151 0.0099

ARG 2151 ASP 2152 0.0244

ASP 2152 ARG 2153 0.0302

ARG 2153 SER 2154 0.0249

SER 2154 TYR 2155 0.0395

TYR 2155 MET 2156 0.0239

MET 2156 PHE 2157 0.0808

PHE 2157 ALA 2158 0.0590

ALA 2158 GLU 2159 0.0593

GLU 2159 ALA 2160 0.0331

ALA 2160 LEU 2161 0.0299

LEU 2161 PRO 2162 0.0580

PRO 2162 LYS 2163 0.0595

LYS 2163 ILE 2164 0.0327

ILE 2164 MET 2165 0.0423

MET 2165 THR 2166 0.0589

THR 2166 LEU 2167 0.0547

LEU 2167 LEU 2168 0.0248

LEU 2168 GLN 2169 0.0562

GLN 2169 GLU 2170 0.0592

GLU 2170 LYS 2171 0.0414

LYS 2171 ALA 2172 0.0309

ALA 2172 ILE 2173 0.0850

ILE 2173 ARG 2174 0.0318

ARG 2174 PRO 2175 0.0620

PRO 2175 VAL 2176 0.0619

VAL 2176 THR 2177 0.0189

THR 2177 PRO 2178 0.0419

PRO 2178 ILE 2179 0.0598

ILE 2179 SER 2180 0.0565

SER 2180 ILE 2181 0.0583

ILE 2181 TYR 2182 0.0618

TYR 2182 LYS 2183 0.0612

LYS 2183 ILE 2184 0.0241

ILE 2184 GLY 2185 0.0454

GLY 2185 ASP 2186 0.0619

ASP 2186 ILE 2187 0.0028

ILE 2187 GLU 2188 0.0608

GLU 2188 THR 2189 0.0542

THR 2189 ALA 2190 0.0518

ALA 2190 PHE 2191 0.0150

PHE 2191 ARG 2192 0.0587

ARG 2192 LEU 2193 0.0556

LEU 2193 MET 2194 0.0154

MET 2194 GLN 2195 0.0511

GLN 2195 ALA 2196 0.0429

ALA 2196 GLY 2197 0.0627

GLY 2197 LYS 2198 0.0048

LYS 2198 HIS 2199 0.0661

HIS 2199 MET 2200 0.0668

MET 2200 GLY 2201 0.0610

GLY 2201 LYS 2202 0.0647

LYS 2202 ILE 2203 0.0607

ILE 2203 VAL 2204 0.0648

VAL 2204 ILE 2205 0.1425

ILE 2205 THR 2206 0.0665

THR 2206 ALA 2207 0.0658

ALA 2207 PRO 2208 0.0439

PRO 2208 GLU 2209 0.0682

GLU 2209 ASP 2210 0.0267

ASP 2210 ALA 2211 0.0627

ALA 2211 MET 2212 0.0692

MET 2212 VAL 2213 0.0468

VAL 2213 PRO 2214 0.0687

PRO 2214 VAL 2215 0.0262

VAL 2215 ILE 2216 0.0542

ILE 2216 THR 2217 0.0529

THR 2217 ARG 2218 0.0194

ARG 2218 PRO 2219 0.0630

PRO 2219 PRO 2220 0.0213

PRO 2220 LYS 2221 0.3330

LYS 2221 LEU 2222 0.0220

LEU 2222 GLN 2223 0.0543

GLN 2223 LEU 2224 0.0178

LEU 2224 ARG 2225 0.0561

ARG 2225 PRO 2226 0.0301

PRO 2226 ASP 2227 0.0557

ASP 2227 ALA 2228 0.0578

ALA 2228 SER 2229 0.0325

SER 2229 TYR 2230 0.0568

TYR 2230 LEU 2231 0.0378

LEU 2231 ILE 2232 0.0587

ILE 2232 VAL 2233 0.0431

VAL 2233 GLY 2234 0.0509

GLY 2234 GLY 2235 0.0576

GLY 2235 LEU 2236 0.0285

LEU 2236 GLY 2237 0.0187

GLY 2237 GLY 2238 0.0231

GLY 2238 ILE 2239 0.0117

ILE 2239 GLY 2240 0.0302

GLY 2240 ARG 2241 0.0361

ARG 2241 SER 2242 0.0044

SER 2242 LEU 2243 0.0341

LEU 2243 CYS 2244 0.0219

CYS 2244 LYS 2245 0.0348

LYS 2245 ASN 2246 0.0030

ASN 2246 PHE 2247 0.0375

PHE 2247 VAL 2248 0.0301

VAL 2248 GLU 2249 0.0188

GLU 2249 ASN 2250 0.0217

ASN 2250 GLY 2251 0.0315

GLY 2251 ALA 2252 0.0165

ALA 2252 ARG 2253 0.1371

ARG 2253 SER 2254 0.0328

SER 2254 LEU 2255 0.0512

LEU 2255 VAL 2256 0.0330

VAL 2256 LEU 2257 0.0478

LEU 2257 LEU 2258 0.0442

LEU 2258 SER 2259 0.0358

SER 2259 ARG 2260 0.0221

ARG 2260 ASN 2261 0.0413

ASN 2261 ALA 2262 0.0510

ALA 2262 ASN 2263 0.0133

ASN 2263 VAL 2264 0.0502

VAL 2264 SER 2265 0.0519

SER 2265 GLN 2266 0.0480

GLN 2266 GLN 2267 0.0284

GLN 2267 SER 2268 0.0265

SER 2268 GLY 2269 0.0180

GLY 2269 GLU 2270 0.0127

GLU 2270 PHE 2271 0.0283

PHE 2271 LEU 2272 0.0349

LEU 2272 ASP 2273 0.0384

ASP 2273 GLU 2274 0.0072

GLU 2274 LEU 2275 0.0380

LEU 2275 ARG 2276 0.0339

ARG 2276 SER 2277 0.0281

SER 2277 THR 2278 0.0143

THR 2278 GLY 2279 0.0346

GLY 2279 CYS 2280 0.0367

CYS 2280 ILE 2281 0.0122

ILE 2281 VAL 2282 0.0289

VAL 2282 GLY 2283 0.0155

GLY 2283 VAL 2284 0.0273

VAL 2284 VAL 2285 -0.1248

VAL 2285 ASP 2286 0.0618

ASP 2286 CYS 2287 0.0492

CYS 2287 ASP 2288 0.0602

ASP 2288 ILE 2289 0.0249

ILE 2289 SER 2290 0.0684

SER 2290 SER 2291 0.0213

SER 2291 LYS 2292 0.0653

LYS 2292 THR 2293 0.0089

THR 2293 GLN 2294 0.0683

GLN 2294 VAL 2295 0.0151

VAL 2295 GLU 2296 0.0620

GLU 2296 ALA 2297 0.0208

ALA 2297 THR 2298 0.0504

THR 2298 MET 2299 0.0409

MET 2299 LEU 2300 0.0305

LEU 2300 ARG 2301 -0.0077

ARG 2301 LEU 2302 0.0163

LEU 2302 LYS 2303 0.0466

LYS 2303 LYS 2304 0.0176

LYS 2304 ASP 2305 0.0513

ASP 2305 MET 2306 0.0068

MET 2306 LEU 2307 0.0114

LEU 2307 PRO 2308 0.0341

PRO 2308 ILE 2309 0.0467

ILE 2309 ARG 2310 0.0011

ARG 2310 GLY 2311 0.0505

GLY 2311 ILE 2312 0.0447

ILE 2312 VAL 2313 0.0511

VAL 2313 HIS 2314 0.0430

HIS 2314 ALA 2315 0.0509

ALA 2315 GLY 2316 0.0215

GLY 2316 MET 2317 0.0285

MET 2317 VAL 2318 0.0822

VAL 2318 LEU 2319 0.0692

LEU 2319 GLN 2320 0.0900

GLN 2320 ASP 2321 0.0418

ASP 2321 SER 2322 0.0852

SER 2322 VAL 2323 0.0225

VAL 2323 PHE 2324 0.0887

PHE 2324 GLU 2325 0.0907

GLU 2325 ARG 2326 0.0127

ARG 2326 MET 2327 0.0849

MET 2327 SER 2328 0.0411

SER 2328 LEU 2329 0.0909

LEU 2329 ASP 2330 0.0342

ASP 2330 ASP 2331 0.0705

ASP 2331 TYR 2332 0.0421

TYR 2332 ASN 2333 -0.1013

ASN 2333 THR 2334 0.0569

THR 2334 ALA 2335 0.0188

ALA 2335 ILE 2336 0.0577

ILE 2336 ARG 2337 0.0259

ARG 2337 PRO 2338 0.0690

PRO 2338 LYS 2339 0.0027

LYS 2339 VAL 2340 0.0688

VAL 2340 GLN 2341 0.0186

GLN 2341 GLY 2342 0.0645

GLY 2342 SER 2343 0.0201

SER 2343 TRP 2344 0.0688

TRP 2344 ASN 2345 0.0064

ASN 2345 LEU 2346 0.0648

LEU 2346 HIS 2347 0.0284

HIS 2347 SER 2348 0.0459

SER 2348 GLY 2349 0.0524

GLY 2349 LEU 2350 0.0317

LEU 2350 SER 2351 0.0355

SER 2351 ASP 2352 0.0430

ASP 2352 CYS 2353 0.0486

CYS 2353 ASP 2354 0.0157

ASP 2354 LEU 2355 0.0487

LEU 2355 ASP 2356 0.0298

ASP 2356 PHE 2357 0.0506

PHE 2357 PHE 2358 0.0453

PHE 2358 ILE 2359 0.0494

ILE 2359 MET 2360 0.0482

MET 2360 LEU 2361 0.0505

LEU 2361 SER 2362 0.0435

SER 2362 SER 2363 0.0468

SER 2363 LEU 2364 0.0139

LEU 2364 ALA 2365 0.1231

ALA 2365 GLY 2366 0.0710

GLY 2366 VAL 2367 0.0097

VAL 2367 SER 2368 0.0668

SER 2368 GLY 2369 0.0537

GLY 2369 SER 2370 0.0468

SER 2370 ALA 2371 0.0712

ALA 2371 SER 2372 0.0125

SER 2372 GLN 2373 0.0695

GLN 2373 ALA 2374 0.0634

ALA 2374 ASN 2375 0.0226

ASN 2375 TYR 2376 0.0718

TYR 2376 THR 2377 0.0030

THR 2377 ALA 2378 0.0710

ALA 2378 GLY 2379 0.0344

GLY 2379 GLY 2380 0.0482

GLY 2380 ALA 2381 0.0579

ALA 2381 TYR 2382 0.0345

TYR 2382 GLN 2383 0.0570

GLN 2383 ASP 2384 0.0015

ASP 2384 ALA 2385 0.0583

ALA 2385 LEU 2386 0.0221

LEU 2386 ALA 2387 0.0495

ALA 2387 LYS 2388 0.0196

LYS 2388 TYR 2389 0.0411

TYR 2389 ARG 2390 0.0436

ARG 2390 ARG 2391 0.0185

ARG 2391 ALA 2392 0.0492

ALA 2392 GLN 2393 0.0216

GLN 2393 GLY 2394 0.0575

GLY 2394 LEU 2395 0.0236

LEU 2395 SER 2396 0.0588

SER 2396 ALA 2397 0.1224

ALA 2397 VAL 2398 0.0472

VAL 2398 SER 2399 0.0514

SER 2399 ILE 2400 0.0528

ILE 2400 ASP 2401 0.0525

ASP 2401 LEU 2402 0.0434

LEU 2402 GLY 2403 0.0495

GLY 2403 MET 2404 0.0351

MET 2404 VAL 2405 0.0436

VAL 2405 GLN 2406 0.0525

GLN 2406 SER 2407 0.0311

SER 2407 VAL 2408 0.0330

VAL 2408 GLY 2409 0.0443

GLY 2409 TYR 2410 0.0523

TYR 2410 VAL 2411 0.0248

VAL 2411 ALA 2412 0.0481

ALA 2412 GLU 2413 0.0756

GLU 2413 THR 2414 0.0511

THR 2414 LYS 2415 0.0478

LYS 2415 GLY 2416 0.0153

GLY 2416 VAL 2417 0.0511

VAL 2417 ALA 2418 0.0321

ALA 2418 GLU 2419 0.0403

GLU 2419 ARG 2420 0.0550

ARG 2420 LEU 2421 0.0489

LEU 2421 VAL 2422 0.0281

VAL 2422 ARG 2423 0.0497

ARG 2423 MET 2424 0.0548

MET 2424 GLY 2425 0.0348

GLY 2425 TYR 2426 0.0314

TYR 2426 SER 2427 0.0540

SER 2427 PRO 2428 0.0211

PRO 2428 ILE 2429 0.0496

ILE 2429 SER 2430 0.0308

SER 2430 GLU 2431 0.0214

GLU 2431 MET 2432 0.0172

MET 2432 GLU 2433 0.0214

GLU 2433 VAL 2434 0.0184

VAL 2434 LEU 2435 0.0353

LEU 2435 LYS 2436 0.0014

LYS 2436 ILE 2437 0.0359

ILE 2437 VAL 2438 0.0154

VAL 2438 GLU 2439 0.0317

GLU 2439 HIS 2440 0.0074

HIS 2440 ALA 2441 0.0301

ALA 2441 ILE 2442 0.0307

ILE 2442 THR 2443 0.0126

THR 2443 ASN 2444 0.0182

ASN 2444 PRO 2445 -0.1278

PRO 2445 PRO 2446 0.0187

PRO 2446 PRO 2447 0.0387

PRO 2447 GLU 2448 0.0394

GLU 2448 ALA 2449 0.0289

ALA 2449 SER 2450 0.0197

SER 2450 SER 2451 0.0413

SER 2451 ALA 2452 0.0012

ALA 2452 GLN 2453 0.0405

GLN 2453 ILE 2454 0.0397

ILE 2454 ILE 2455 0.0370

ILE 2455 THR 2456 0.0410

THR 2456 GLY 2457 0.0409

GLY 2457 ILE 2458 0.0097

ILE 2458 SER 2459 0.0254

SER 2459 THR 2460 0.0075

THR 2460 LYS 2461 -0.0566

LYS 2461 PRO 2462 0.0226

PRO 2462 GLY 2463 0.0189

GLY 2463 ARG 2464 0.0253

ARG 2464 HIS 2465 0.0176

HIS 2465 TRP 2466 0.0153

TRP 2466 THR 2467 0.0304

THR 2467 GLU 2468 0.0031

GLU 2468 SER 2469 0.0237

SER 2469 SER 2470 0.0295

SER 2470 TRP 2471 0.0296

TRP 2471 LEU 2472 0.0073

LEU 2472 GLN 2473 0.0251

GLN 2473 ASP 2474 0.0269

ASP 2474 ALA 2475 0.0148

ALA 2475 ARG 2476 0.0251

ARG 2476 PHE 2477 0.1265

PHE 2477 ALA 2478 0.0102

ALA 2478 THR 2479 0.0196

THR 2479 LEU 2480 0.0239

LEU 2480 ARG 2481 0.0208

ARG 2481 GLU 2482 0.0073

GLU 2482 ARG 2483 0.0236

ARG 2483 ALA 2484 0.0238

ALA 2484 ARG 2485 0.0128

ARG 2485 ASP 2486 0.0156

ASP 2486 VAL 2487 0.0239

VAL 2487 LYS 2488 0.0219

LYS 2488 GLU 2489 0.0101

GLU 2489 LEU 2490 0.0218

LEU 2490 SER 2491 0.0237

SER 2491 ASN 2492 0.0144

ASN 2492 SER 2493 0.1595

SER 2493 GLN 2494 0.0603

GLN 2494 ASN 989 -0.0766

ASN 989 LYS 990 0.0248

LYS 990 ALA 991 0.0080

ALA 991 HIS 992 0.0207

HIS 992 ARG 993 0.0082

ARG 993 GLN 994 0.0177

GLN 994 ARG 995 0.0149

ARG 995 VAL 996 0.0233

VAL 996 HIS 997 0.0196

HIS 997 PRO 998 0.0208

PRO 998 PRO 999 0.0173

PRO 999 HIS 1000 0.0128

HIS 1000 ASP 1001 0.0233

ASP 1001 LEU 1002 0.0011

LEU 1002 LEU 1003 0.0247

LEU 1003 GLY 1004 0.0081

GLY 1004 SER 1005 -0.2575

SER 1005 LEU 1006 0.0262

LEU 1006 ILE 1007 0.0301

ILE 1007 VAL 1008 0.0181

VAL 1008 GLY 1009 0.0272

GLY 1009 ARG 1010 0.0023

ARG 1010 ASP 1011 0.0234

ASP 1011 LEU 1012 0.0303

LEU 1012 ARG 1013 0.0029

ARG 1013 GLU 1014 0.0289

GLU 1014 PRO 1015 0.0138

PRO 1015 THR 1016 0.0299

THR 1016 TRP 1017 0.0214

TRP 1017 ARG 1018 0.0269

ARG 1018 HIS 1019 0.0296

HIS 1019 PHE 1020 0.0266

PHE 1020 ILE 1021 -0.6114

ILE 1021 ARG 1022 0.0272

ARG 1022 VAL 1023 0.0285

VAL 1023 GLN 1024 0.0041

GLN 1024 ASP 1025 0.0255

ASP 1025 ILE 1026 0.0160

ILE 1026 PRO 1027 0.0278

PRO 1027 TRP 1028 0.0209

TRP 1028 ILE 1029 0.0155

ILE 1029 ARG 1030 0.0281

ARG 1030 ASP 1031 0.0261

ASP 1031 HIS 1032 0.0163

HIS 1032 VAL 1033 0.0135

VAL 1033 VAL 1034 0.0046

VAL 1034 GLN 1035 0.0159

GLN 1035 SER 1036 0.0150

SER 1036 ALA 1037 0.0580

ALA 1037 LEU 1038 0.0064

LEU 1038 VAL 1039 0.0292

VAL 1039 TYR 1040 0.0182

TYR 1040 PRO 1041 0.0301

PRO 1041 GLY 1042 0.0229

GLY 1042 ALA 1043 0.0173

ALA 1043 GLY 1044 0.0171

GLY 1044 PHE 1045 0.0261

PHE 1045 ILE 1046 0.0309

ILE 1046 CYS 1047 0.0035

CYS 1047 MET 1048 0.0305

MET 1048 ALA 1049 0.0279

ALA 1049 MET 1050 0.0204

MET 1050 GLU 1051 0.0115

GLU 1051 ALA 1052 0.0297

ALA 1052 MET 1053 0.0847

MET 1053 VAL 1054 0.0078

VAL 1054 GLN 1055 0.0053

GLN 1055 LEU 1056 0.0095

LEU 1056 HIS 1057 0.0129

HIS 1057 GLU 1058 0.0013

GLU 1058 LEU 1059 0.0124

LEU 1059 ARG 1060 0.0070

ARG 1060 ASP 1061 0.0131

ASP 1061 SER 1062 0.0070

SER 1062 GLN 1063 0.0063

GLN 1063 SER 1064 0.0134

SER 1064 ARG 1065 0.0003

ARG 1065 LYS 1066 0.0131

LYS 1066 VAL 1067 0.0113

VAL 1067 ALA 1068 0.0040

ALA 1068 GLY 1069 0.1199

GLY 1069 TYR 1070 0.0135

TYR 1070 ARG 1071 0.0026

ARG 1071 LEU 1072 0.0118

LEU 1072 ALA 1073 0.0029

ALA 1073 GLU 1074 0.0079

GLU 1074 VAL 1075 0.0191

VAL 1075 ASP 1076 0.0131

ASP 1076 ILE 1077 0.0215

ILE 1077 LEU 1078 0.0159

LEU 1078 ARG 1079 0.0209

ARG 1079 ALA 1080 0.0168

ALA 1080 MET 1081 0.0062

MET 1081 LEU 1082 0.0220

LEU 1082 ILE 1083 0.0035

ILE 1083 PRO 1084 0.0218

PRO 1084 ASP 1085 0.0312

ASP 1085 THR 1086 0.0205

THR 1086 SER 1087 0.0078

SER 1087 GLU 1088 0.0245

GLU 1088 GLY 1089 0.0160

GLY 1089 LEU 1090 0.0128

LEU 1090 GLU 1091 0.0313

GLU 1091 ALA 1092 0.0220

ALA 1092 HIS 1093 0.0305

HIS 1093 ILE 1094 0.0276

ILE 1094 SER 1095 0.0291

SER 1095 LEU 1096 0.0294

LEU 1096 ARG 1097 0.0213

ARG 1097 PRO 1098 0.0294

PRO 1098 CYS 1099 0.0011

CYS 1099 SER 1100 0.0256

SER 1100 THR 1101 0.0766

THR 1101 LYS 1102 0.0008

LYS 1102 LEU 1103 0.0217

LEU 1103 LEU 1104 0.0213

LEU 1104 LEU 1105 0.0057

LEU 1105 THR 1106 0.0139

THR 1106 ASN 1107 0.0073

ASN 1107 GLU 1108 0.0175

GLU 1108 TRP 1109 0.0188

TRP 1109 TYR 1110 0.0204

TYR 1110 ASP 1111 0.0150

ASP 1111 PHE 1112 0.0142

PHE 1112 CYS 1113 0.0214

CYS 1113 VAL 1114 0.0157

VAL 1114 SER 1115 0.0217

SER 1115 SER 1116 0.0171

SER 1116 VAL 1117 -0.0052

VAL 1117 GLY 1118 0.0131

GLY 1118 ASP 1119 0.0110

ASP 1119 ASP 1120 0.0092

ASP 1120 ASP 1121 0.0122

ASP 1121 LYS 1122 0.0026

LYS 1122 PHE 1123 0.0136

PHE 1123 VAL 1124 0.0096

VAL 1124 ASP 1125 0.0126

ASP 1125 HIS 1126 0.0137

HIS 1126 CYS 1127 0.0131

CYS 1127 ARG 1128 0.0124

ARG 1128 GLY 1129 0.0133

GLY 1129 ARG 1130 0.0129

ARG 1130 ILE 1131 0.0053

ILE 1131 THR 1132 0.0123

THR 1132 ILE 1133 0.1270

ILE 1133 GLU 1134 0.0157

GLU 1134 PHE 1135 0.0138

PHE 1135 ASP 1136 0.0055

ASP 1136 THR 1137 0.0243

THR 1137 SER 1138 0.0077

SER 1138 GLY 1139 0.0246

GLY 1139 SER 1140 0.0214

SER 1140 ALA 1141 0.0111

ALA 1141 ASP 1142 0.0247

ASP 1142 THR 1143 0.0106

THR 1143 PRO 1144 0.0158

PRO 1144 ARG 1145 0.0187

ARG 1145 THR 1146 0.0245

THR 1146 SER 1147 0.0118

SER 1147 LEU 1148 0.0217

LEU 1148 ARG 1149 -0.5084

ARG 1149 GLU 1150 0.0088

GLU 1150 ARG 1151 0.0072

ARG 1151 SER 1152 0.0124

SER 1152 ARG 1153 0.0105

ARG 1153 SER 1154 0.0018

SER 1154 THR 1155 0.0082

THR 1155 GLY 1156 0.0115

GLY 1156 LEU 1157 0.0127

LEU 1157 MET 1158 0.0073

MET 1158 ARG 1159 0.0122

ARG 1159 SER 1160 0.0054

SER 1160 VAL 1161 0.0128

VAL 1161 ASP 1162 0.0088

ASP 1162 PRO 1163 0.0104

PRO 1163 SER 1164 0.0122

SER 1164 ASN 1165 0.2342

ASN 1165 LEU 1166 0.0094

LEU 1166 TYR 1167 0.0069

TYR 1167 SER 1168 0.0047

SER 1168 PHE 1169 0.0057

PHE 1169 LEU 1170 0.0063

LEU 1170 ARG 1171 0.0098

ARG 1171 ALA 1172 0.0001

ALA 1172 GLN 1173 0.0098

GLN 1173 GLY 1174 0.0052

GLY 1174 ILE 1175 0.0036

ILE 1175 TYR 1176 0.0058

TYR 1176 HIS 1177 0.0036

HIS 1177 GLY 1178 0.0067

GLY 1178 PRO 1179 0.0066

PRO 1179 ILE 1180 0.0047

ILE 1180 PHE 1181 0.0294

PHE 1181 GLN 1182 0.0099

GLN 1182 ASN 1183 0.0081

ASN 1183 LEU 1184 0.0062

LEU 1184 LYS 1185 0.0114

LYS 1185 THR 1186 0.0065

THR 1186 ILE 1187 0.0034

ILE 1187 SER 1188 0.0094

SER 1188 SER 1189 0.0041

SER 1189 ARG 1190 0.0046

ARG 1190 LYS 1191 0.0055

LYS 1191 ASP 1192 0.0080

ASP 1192 HIS 1193 0.0014

HIS 1193 SER 1194 0.0065

SER 1194 GLU 1195 0.0016

GLU 1195 SER 1196 0.0092

SER 1196 SER 1197 -0.0443

SER 1197 PHE 1198 0.0108

PHE 1198 VAL 1199 0.0018

VAL 1199 VAL 1200 0.0091

VAL 1200 ALA 1201 0.0177

ALA 1201 ASN 1202 0.0043

ASN 1202 THR 1203 0.0179

THR 1203 ALA 1204 0.0010

ALA 1204 SER 1205 0.0176

SER 1205 VAL 1206 0.0137

VAL 1206 MET 1207 0.0112

MET 1207 PRO 1208 0.0084

PRO 1208 ASN 1209 0.0066

ASN 1209 GLY 1210 0.0136

GLY 1210 PHE 1211 0.0170

PHE 1211 GLN 1212 0.0113

GLN 1212 SER 1213 0.1327

SER 1213 PRO 1214 0.0253

PRO 1214 HIS 1215 0.0021

HIS 1215 VAL 1216 0.0172

VAL 1216 ILE 1217 0.0150

ILE 1217 HIS 1218 0.0254

HIS 1218 PRO 1219 0.0074

PRO 1219 THR 1220 0.0252

THR 1220 THR 1221 0.0254

THR 1221 LEU 1222 0.0139

LEU 1222 ASP 1223 0.0173

ASP 1223 SER 1224 0.0254

SER 1224 ILE 1225 0.0211

ILE 1225 PHE 1226 0.0128

PHE 1226 GLN 1227 0.0249

GLN 1227 GLY 1228 0.0250

GLY 1228 ALA 1229 0.0099

ALA 1229 TYR 1230 0.0119

TYR 1230 THR 1231 0.0156

THR 1231 ALA 1232 0.0111

ALA 1232 LEU 1233 0.0059

LEU 1233 PRO 1234 0.0105

PRO 1234 GLY 1235 0.0137

GLY 1235 ALA 1236 0.0048

ALA 1236 GLY 1237 0.0142

GLY 1237 LEU 1238 0.0163

LEU 1238 ASP 1239 0.0004

ASP 1239 GLN 1240 0.0167

GLN 1240 ASN 1241 0.0105

ASN 1241 THR 1242 0.0114

THR 1242 ALA 1243 0.0020

ALA 1243 MET 1244 0.0162

MET 1244 ILE 1245 -0.1463

ILE 1245 PRO 1246 0.0261

PRO 1246 ARG 1247 0.0259

ARG 1247 SER 1248 0.0292

SER 1248 ILE 1249 0.0207

ILE 1249 GLN 1250 0.0332

GLN 1250 GLU 1251 0.0039

GLU 1251 LEU 1252 0.0131

LEU 1252 TYR 1253 0.0076

TYR 1253 LEU 1254 0.0112

LEU 1254 SER 1255 0.0114

SER 1255 SER 1256 0.0060

SER 1256 ALA 1257 0.0323

ALA 1257 LEU 1258 0.0252

LEU 1258 THR 1259 0.0196

THR 1259 SER 1260 0.0327

SER 1260 ASP 1261 0.1286

ASP 1261 VAL 1262 0.0198

VAL 1262 GLY 1263 0.0149

GLY 1263 GLN 1264 0.0206

GLN 1264 CYS 1265 0.0037

CYS 1265 LEU 1266 0.0134

LEU 1266 VAL 1267 0.0048

VAL 1267 SER 1268 0.0089

SER 1268 ASP 1269 0.0082

ASP 1269 THR 1270 0.0095

THR 1270 SER 1271 0.0057

SER 1271 LEU 1272 0.0083

LEU 1272 ILE 1273 0.0188

ILE 1273 ARG 1274 0.0123

ARG 1274 TYR 1275 0.0198

TYR 1275 ASP 1276 0.0098

ASP 1276 GLY 1277 0.1389

GLY 1277 GLN 1278 0.0270

GLN 1278 SER 1279 0.0159

SER 1279 PHE 1280 0.0211

PHE 1280 THR 1281 0.0199

THR 1281 VAL 1282 0.0127

VAL 1282 ASN 1283 0.0133

ASN 1283 VAL 1284 0.0069

VAL 1284 ASP 1285 0.0115

ASP 1285 VAL 1286 0.0091

VAL 1286 SER 1287 0.0113

SER 1287 SER 1288 0.0089

SER 1288 LYS 1289 0.0294

LYS 1289 ALA 1290 0.0044

ALA 1290 ASP 1291 0.0276

ASP 1291 SER 1292 0.0277

SER 1292 GLU 1293 0.0310

GLU 1293 HIS 1294 0.0201

HIS 1294 THR 1295 0.0302

THR 1295 PRO 1296 0.0213

PRO 1296 VAL 1297 0.0213

VAL 1297 LEU 1298 0.0098

LEU 1298 GLU 1299 0.0073

GLU 1299 ILE 1300 0.0095

ILE 1300 LYS 1301 0.0106

LYS 1301 GLY 1302 0.0069

GLY 1302 LEU 1303 0.0290

LEU 1303 ARG 1304 0.0075

ARG 1304 ASN 1305 0.0299

ASN 1305 GLN 1306 0.0122

GLN 1306 SER 1307 0.0239

SER 1307 VAL 1308 0.0297

VAL 1308 GLY 1309 0.2154

GLY 1309 GLN 1310 0.0361

GLN 1310 MET 1311 0.0031

MET 1311 ALA 1312 0.0372

ALA 1312 PRO 1313 0.0389

PRO 1313 GLN 1314 0.0005

GLN 1314 PRO 1315 0.0353

PRO 1315 GLY 1316 0.0388

GLY 1316 ASP 1317 0.0171

ASP 1317 SER 1318 0.0198

SER 1318 SER 1319 0.0226

SER 1319 ASN 1320 0.0383

ASN 1320 ASN 1321 0.0180

ASN 1321 ASP 1322 0.0367

ASP 1322 LEU 1323 0.0292

LEU 1323 CYS 1324 0.0346

CYS 1324 PHE 1325 -0.0218

PHE 1325 LYS 1326 0.0086

LYS 1326 LEU 1327 0.0107

LEU 1327 ASP 1328 0.0012

ASP 1328 TRP 1329 0.0083

TRP 1329 ALA 1330 0.0018

ALA 1330 PRO 1331 0.0046

PRO 1331 ASP 1332 0.0168

ASP 1332 ILE 1333 0.0060

ILE 1333 SER 1334 0.0158

SER 1334 SER 1335 0.0164

SER 1335 VAL 1336 0.0142

VAL 1336 LYS 1337 0.0035

LYS 1337 GLN 1338 0.0082

GLN 1338 GLU 1339 0.0160

GLU 1339 ARG 1340 0.0026

ARG 1340 LEU 1341 -0.2656

LEU 1341 LYS 1342 0.0497

LYS 1342 GLU 1343 0.0081

GLU 1343 LYS 1344 0.0526

LYS 1344 PHE 1345 0.0166

PHE 1345 GLY 1346 0.0453

GLY 1346 PHE 1347 0.0563

PHE 1347 PRO 1348 0.0560

PRO 1348 LEU 1349 0.0289

LEU 1349 ASP 1350 0.0544

ASP 1350 PRO 1351 0.0536

PRO 1351 THR 1352 0.0537

THR 1352 GLU 1353 0.0336

GLU 1353 ALA 1354 0.0478

ALA 1354 ASP 1355 0.0550

ASP 1355 ILE 1356 0.0478

ILE 1356 ILE 1357 0.2244

ILE 1357 MET 1358 0.1113

MET 1358 GLY 1359 0.1203

GLY 1359 LEU 1360 0.1270

LEU 1360 ARG 1361 0.1131

ARG 1361 GLN 1362 0.1119

GLN 1362 ALA 1363 0.1287

ALA 1363 CYS 1364 0.1221

CYS 1364 ILE 1365 0.1012

ILE 1365 HIS 1366 0.1203

HIS 1366 PHE 1367 0.1290

PHE 1367 ILE 1368 0.1212

ILE 1368 HIS 1369 0.1069

HIS 1369 ARG 1370 0.1207

ARG 1370 SER 1371 0.1296

SER 1371 LEU 1372 0.1158

LEU 1372 GLN 1373 0.1190

GLN 1373 SER 1374 0.1402

SER 1374 LEU 1375 0.1446

LEU 1375 THR 1376 0.0067

THR 1376 ALA 1377 0.1272

ALA 1377 PRO 1378 0.1450

PRO 1378 ASP 1379 0.0168

ASP 1379 ARG 1380 0.1362

ARG 1380 ASP 1381 0.1082

ASP 1381 GLN 1382 0.1235

GLN 1382 LEU 1383 0.0209

LEU 1383 ASP 1384 0.1065

ASP 1384 TRP 1385 0.1304

TRP 1385 HIS 1386 0.0376

HIS 1386 GLN 1387 0.1214

GLN 1387 LYS 1388 0.1130

LYS 1388 ARG 1389 -0.0071

ARG 1389 PHE 1390 0.1293

PHE 1390 TYR 1391 0.0536

TYR 1391 ASP 1392 0.1485

ASP 1392 TRP 1393 0.0127

TRP 1393 MET 1394 0.1419

MET 1394 VAL 1395 0.0917

VAL 1395 LEU 1396 0.0810

LEU 1396 GLN 1397 0.0942

GLN 1397 ILE 1398 0.0888

ILE 1398 GLN 1399 0.1469

GLN 1399 LEU 1400 0.0042

LEU 1400 ALA 1401 0.1496

ALA 1401 GLU 1402 0.0768

GLU 1402 GLU 1403 0.1204

GLU 1403 ASP 1404 0.0473

ASP 1404 ARG 1405 0.1744

ARG 1405 LEU 1406 0.1325

LEU 1406 ALA 1407 0.1089

ALA 1407 PRO 1408 0.1495

PRO 1408 ASN 1409 0.0643

ASN 1409 SER 1410 0.1394

SER 1410 SER 1411 0.0173

SER 1411 ALA 1412 0.1448

ALA 1412 TRP 1413 0.1444

TRP 1413 LEU 1414 0.0074

LEU 1414 GLN 1415 0.1449

GLN 1415 CYS 1416 0.1005

CYS 1416 SER 1417 0.1393

SER 1417 SER 1418 0.1494

SER 1418 SER 1419 0.0741

SER 1419 ASP 1420 0.1003

ASP 1420 GLU 1421 0.2099

GLU 1421 GLN 1422 0.1328

GLN 1422 LYS 1423 0.0280

LYS 1423 LEU 1424 0.1378

LEU 1424 LEU 1425 0.1315

LEU 1425 GLU 1426 0.0939

GLU 1426 ASN 1427 0.0638

ASN 1427 VAL 1428 0.1358

VAL 1428 ARG 1429 0.1394

ARG 1429 ALA 1430 0.0373

ALA 1430 SER 1431 0.1114

SER 1431 SER 1432 0.1398

SER 1432 VAL 1433 0.1255

VAL 1433 ASN 1434 0.0999

ASN 1434 GLY 1435 0.1182

GLY 1435 GLN 1436 0.1378

GLN 1436 MET 1437 0.0951

MET 1437 VAL 1438 0.0926

VAL 1438 VAL 1439 0.1158

VAL 1439 HIS 1440 0.1286

HIS 1440 VAL 1441 0.1042

VAL 1441 GLY 1442 0.1083

GLY 1442 LYS 1443 0.1076

LYS 1443 SER 1444 0.1130

SER 1444 MET 1445 0.1259

MET 1445 LEU 1446 0.0034

LEU 1446 ALA 1447 0.1306

ALA 1447 ILE 1448 0.0985

ILE 1448 LEU 1449 0.0809

LEU 1449 ARG 1450 0.0644

ARG 1450 HIS 1451 0.1041

HIS 1451 GLU 1452 0.1294

GLU 1452 ILE 1453 0.0559

ILE 1453 ALA 1454 0.0623

ALA 1454 PRO 1455 0.0676

PRO 1455 LEU 1456 0.0299

LEU 1456 GLU 1457 0.0921

GLU 1457 LEU 1458 0.0912

LEU 1458 MET 1459 0.0395

MET 1459 LEU 1460 0.0634

LEU 1460 GLN 1461 0.0907

GLN 1461 ASP 1462 0.0292

ASP 1462 LYS 1463 0.0747

LYS 1463 LEU 1464 0.0796

LEU 1464 LEU 1465 0.0920

LEU 1465 TYR 1466 0.0067

TYR 1466 ARG 1467 0.0880

ARG 1467 TYR 1468 0.0635

TYR 1468 TYR 1469 0.1512

TYR 1469 THR 1470 0.0172

THR 1470 ASP 1471 0.0557

ASP 1471 ALA 1472 0.0279

ALA 1472 ILE 1473 0.0553

ILE 1473 LYS 1474 0.0468

LYS 1474 TRP 1475 0.0530

TRP 1475 ASP 1476 0.0072

ASP 1476 ARG 1477 0.0548

ARG 1477 SER 1478 0.0514

SER 1478 TYR 1479 0.0428

TYR 1479 GLN 1480 0.0188

GLN 1480 GLN 1481 0.0564

GLN 1481 ILE 1482 0.0567

ILE 1482 ASP 1483 0.0207

ASP 1483 GLN 1484 0.0411

GLN 1484 LEU 1485 0.0417

LEU 1485 VAL 1486 0.0103

VAL 1486 LYS 1487 0.0142

LYS 1487 LEU 1488 0.0190

LEU 1488 HIS 1489 0.0179

HIS 1489 ALA 1490 0.0098

ALA 1490 HIS 1491 0.0162

HIS 1491 LYS 1492 0.0190

LYS 1492 CYS 1493 0.0173

CYS 1493 PRO 1494 0.0162

PRO 1494 THR 1495 0.0166

THR 1495 ALA 1496 0.0040

ALA 1496 LYS 1497 0.0185

LYS 1497 ILE 1498 0.0027

ILE 1498 ILE 1499 0.0107

ILE 1499 GLU 1500 0.0053

GLU 1500 ILE 1501 0.0405

ILE 1501 GLY 1502 0.0329

GLY 1502 ALA 1503 0.0221

ALA 1503 GLY 1504 0.0308

GLY 1504 THR 1505 0.0398

THR 1505 GLY 1506 0.0168

GLY 1506 GLY 1507 0.0437

GLY 1507 CYS 1508 0.0408

CYS 1508 THR 1509 0.0244

THR 1509 ARG 1510 0.0354

ARG 1510 ALA 1511 0.0457

ALA 1511 VAL 1512 0.0433

VAL 1512 LEU 1513 0.0252

LEU 1513 ASP 1514 0.0402

ASP 1514 ALA 1515 0.0458

ALA 1515 LEU 1516 0.0383

LEU 1516 SER 1517 -0.0470

SER 1517 ASN 1518 0.0168

ASN 1518 GLN 1519 0.0199

GLN 1519 GLY 1520 0.0230

GLY 1520 ILE 1521 0.0213

ILE 1521 ALA 1522 0.0136

ALA 1522 ARG 1523 0.0224

ARG 1523 CYS 1524 0.0218

CYS 1524 ALA 1525 0.0181

ALA 1525 GLN 1526 0.0138

GLN 1526 TYR 1527 0.0058

TYR 1527 ASP 1528 0.0159

ASP 1528 PHE 1529 0.0147

PHE 1529 THR 1530 0.0106

THR 1530 ASP 1531 0.0069

ASP 1531 VAL 1532 0.0148

VAL 1532 SER 1533 0.1018

SER 1533 SER 1534 0.0140

SER 1534 GLY 1535 0.0373

GLY 1535 PHE 1536 0.0303

PHE 1536 PHE 1537 0.0111

PHE 1537 GLU 1538 0.0392

GLU 1538 ALA 1539 0.0427

ALA 1539 ALA 1540 0.0367

ALA 1540 GLN 1541 0.0153

GLN 1541 GLN 1542 0.0432

GLN 1542 LYS 1543 0.0428

LYS 1543 PHE 1544 0.0272

PHE 1544 ALA 1545 0.0224

ALA 1545 ALA 1546 0.0245

ALA 1546 PHE 1547 0.0423

PHE 1547 ASP 1548 0.0438

ASP 1548 ASP 1549 0.1094

ASP 1549 VAL 1550 0.0335

VAL 1550 ILE 1551 0.0042

ILE 1551 ARG 1552 0.0314

ARG 1552 PHE 1553 0.0066

PHE 1553 GLN 1554 0.0243

GLN 1554 LYS 1555 0.0010

LYS 1555 LEU 1556 0.0392

LEU 1556 ASP 1557 0.0053

ASP 1557 ILE 1558 0.0440

ILE 1558 GLU 1559 0.0095

GLU 1559 LYS 1560 0.0396

LYS 1560 ASP 1561 0.0252

ASP 1561 ILE 1562 0.0062

ILE 1562 GLU 1563 0.0330

GLU 1563 MET 1564 0.0264

MET 1564 GLN 1565 0.0616

GLN 1565 GLY 1566 0.0004

GLY 1566 PHE 1567 0.0352

PHE 1567 GLU 1568 0.0218

GLU 1568 CYS 1569 0.0336

CYS 1569 GLY 1570 0.0266

GLY 1570 SER 1571 0.0256

SER 1571 TYR 1572 0.0348

TYR 1572 ASP 1573 0.0327

ASP 1573 LEU 1574 0.0183

LEU 1574 VAL 1575 0.0044

VAL 1575 ILE 1576 0.0290

ILE 1576 ALA 1577 0.0004

ALA 1577 SER 1578 0.0300

SER 1578 GLN 1579 0.0002

GLN 1579 VAL 1580 0.0371

VAL 1580 LEU 1581 0.0865

LEU 1581 HIS 1582 0.0092

HIS 1582 ALA 1583 0.0301

ALA 1583 THR 1584 0.0359

THR 1584 GLY 1585 0.0254

GLY 1585 LYS 1586 0.0245

LYS 1586 MET 1587 0.0177

MET 1587 GLU 1588 0.0259

GLU 1588 HIS 1589 0.0372

HIS 1589 THR 1590 0.0356

THR 1590 MET 1591 0.0181

MET 1591 ALA 1592 0.0321

ALA 1592 ASN 1593 0.0370

ASN 1593 VAL 1594 0.0316

VAL 1594 ARG 1595 0.0214

ARG 1595 LYS 1596 0.0341

LYS 1596 LEU 1597 -0.1521

LEU 1597 LEU 1598 0.0145

LEU 1598 LYS 1599 0.0087

LYS 1599 PRO 1600 0.0270

PRO 1600 GLY 1601 0.0250

GLY 1601 GLY 1602 0.0239

GLY 1602 LYS 1603 0.0226

LYS 1603 LEU 1604 0.0032

LEU 1604 LEU 1605 0.0268

LEU 1605 LEU 1606 0.0027

LEU 1606 VAL 1607 0.0223

VAL 1607 GLU 1608 0.0026

GLU 1608 THR 1609 0.0116

THR 1609 THR 1610 0.0274

THR 1610 ARG 1611 0.0160

ARG 1611 ASP 1612 0.0139

ASP 1612 GLU 1613 -0.0936

GLU 1613 MET 1614 0.0226

MET 1614 ASP 1615 0.0975

ASP 1615 LEU 1616 0.0936

LEU 1616 GLN 1617 0.0380

GLN 1617 LEU 1618 0.0660

LEU 1618 VAL 1619 0.0872

VAL 1619 PHE 1620 0.1013

PHE 1620 GLY 1621 0.0460

GLY 1621 LEU 1622 0.0657

LEU 1622 LEU 1623 0.0863

LEU 1623 PRO 1624 0.0919

PRO 1624 GLY 1625 0.0129

GLY 1625 TRP 1626 0.1000

TRP 1626 TRP 1627 0.0570

TRP 1627 LEU 1628 0.0977

LEU 1628 SER 1629 0.2418

SER 1629 SER 1630 0.0538

SER 1630 GLU 1631 0.0399

GLU 1631 GLU 1632 0.0469

GLU 1632 GLU 1633 0.0360

GLU 1633 ARG 1634 0.0593

ARG 1634 GLN 1635 0.0004

GLN 1635 MET 1636 0.0599

MET 1636 SER 1637 0.0206

SER 1637 PRO 1638 0.0423

PRO 1638 SER 1639 0.0207

SER 1639 LEU 1640 0.0356

LEU 1640 SER 1641 0.0468

SER 1641 THR 1642 -0.0002

THR 1642 ASN 1643 0.0602

ASN 1643 SER 1644 0.0399

SER 1644 TRP 1645 -0.0090

TRP 1645 GLU 1646 0.0130

GLU 1646 LYS 1647 0.0223

LYS 1647 VAL 1648 0.0271

VAL 1648 LEU 1649 0.0038

LEU 1649 LYS 1650 0.0242

LYS 1650 LYS 1651 0.0172

LYS 1651 THR 1652 0.0272

THR 1652 GLY 1653 0.0004

GLY 1653 PHE 1654 0.0257

PHE 1654 ASP 1655 0.0211

ASP 1655 GLY 1656 0.0149

GLY 1656 LEU 1657 0.0282

LEU 1657 ASP 1658 0.0044

ASP 1658 ILE 1659 0.0249

ILE 1659 GLU 1660 0.0069

GLU 1660 LEU 1661 -0.0032

LEU 1661 ARG 1662 0.0273

ARG 1662 ASP 1663 0.0472

ASP 1663 CYS 1664 0.0462

CYS 1664 ASP 1665 0.0448

ASP 1665 SER 1666 0.0114

SER 1666 ASP 1667 0.0226

ASP 1667 GLU 1668 0.0284

GLU 1668 PHE 1669 0.0436

PHE 1669 TYR 1670 0.0405

TYR 1670 SER 1671 0.0330

SER 1671 PHE 1672 0.0317

PHE 1672 SER 1673 0.0322

SER 1673 VAL 1674 0.0238

VAL 1674 MET 1675 0.0473

MET 1675 MET 1676 0.0311

MET 1676 ALA 1677 0.1673

ALA 1677 THR 1678 0.1172

THR 1678 ALA 1679 0.0809

ALA 1679 SER 1680 0.0992

SER 1680 SER 1681 0.1023

SER 1681 THR 1682 0.0990

THR 1682 ILE 1683 0.0718

ILE 1683 ALA 1684 0.1158

ALA 1684 SER 1685 0.1178

SER 1685 SER 1686 0.0518

SER 1686 SER 1687 0.1179

SER 1687 MET 1688 0.0039

MET 1688 ALA 1689 0.0976

ALA 1689 PHE 1690 0.0715

PHE 1690 ALA 1691 0.0494

ALA 1691 ILE 1692 0.0870

ILE 1692 VAL 1693 0.2183

VAL 1693 TYR 1694 0.0622

TYR 1694 GLY 1695 0.0040

GLY 1695 GLU 1696 0.0533

GLU 1696 VAL 1697 0.0603

VAL 1697 PRO 1698 0.0226

PRO 1698 LEU 1699 0.0299

LEU 1699 PRO 1700 0.0658

PRO 1700 ASP 1701 0.0529

ASP 1701 GLN 1702 0.0385

GLN 1702 PHE 1703 0.0848

PHE 1703 LEU 1704 0.0876

LEU 1704 ASP 1705 0.0210

ASP 1705 ASP 1706 0.0718

ASP 1706 MET 1707 0.0733

MET 1707 LYS 1708 0.0809

LYS 1708 THR 1709 0.0353

THR 1709 ALA 1710 0.0833

ALA 1710 ILE 1711 0.0776

ILE 1711 SER 1712 0.0455

SER 1712 SER 1713 0.0449

SER 1713 SER 1714 0.0768

SER 1714 ALA 1715 0.0800

ALA 1715 VAL 1716 0.0699

VAL 1716 SER 1717 0.0363

SER 1717 ASP 1718 0.0659

ASP 1718 PRO 1719 0.0089

PRO 1719 VAL 1720 0.0374

VAL 1720 VAL 1721 0.0469

VAL 1721 GLY 1722 0.0079

GLY 1722 HIS 1723 0.0058

HIS 1723 LEU 1724 0.0684

LEU 1724 ASP 1725 0.0801

ASP 1725 SER 1726 0.0521

SER 1726 ILE 1727 0.0271

ILE 1727 ASP 1728 0.0828

ASP 1728 ALA 1729 0.0850

ALA 1729 THR 1730 0.0881

THR 1730 GLY 1731 0.0213

GLY 1731 LYS 1732 0.0900

LYS 1732 PHE 1733 0.0919

PHE 1733 CYS 1734 0.0498

CYS 1734 ILE 1735 0.0931

ILE 1735 PHE 1736 0.0075

PHE 1736 ILE 1737 0.0925

ILE 1737 GLU 1738 0.0101

GLU 1738 ASP 1739 0.0819

ASP 1739 PRO 1740 0.0907

PRO 1740 GLU 1741 0.0662

GLU 1741 THR 1742 0.0795

THR 1742 ASP 1743 0.0949

ASP 1743 ILE 1744 0.0923

ILE 1744 LEU 1745 0.0941

LEU 1745 SER 1746 0.0656

SER 1746 SER 1747 0.0455

SER 1747 PRO 1748 0.0895

PRO 1748 ASP 1749 0.0675

ASP 1749 GLU 1750 0.0945

GLU 1750 LYS 1751 0.0545

LYS 1751 SER 1752 0.0471

SER 1752 TYR 1753 0.0949

TYR 1753 ALA 1754 0.0961

ALA 1754 SER 1755 0.0332

SER 1755 ILE 1756 0.0809

ILE 1756 GLN 1757 0.1163

GLN 1757 LYS 1758 0.0626

LYS 1758 LEU 1759 0.0362

LEU 1759 VAL 1760 0.0823

VAL 1760 THR 1761 0.0815

THR 1761 ARG 1762 0.0535

ARG 1762 CYS 1763 0.0379

CYS 1763 LYS 1764 0.0264

LYS 1764 GLY 1765 0.0837

GLY 1765 LEU 1766 0.0687

LEU 1766 ILE 1767 0.0799

ILE 1767 TRP 1768 0.0222

TRP 1768 VAL 1769 0.0809

VAL 1769 SER 1770 0.0532

SER 1770 ARG 1771 0.0835

ARG 1771 GLY 1772 0.0762

GLY 1772 GLY 1773 0.1100

GLY 1773 ALA 1774 0.0400

ALA 1774 MET 1775 0.0577

MET 1775 HIS 1776 0.0540

HIS 1776 GLY 1777 0.0229

GLY 1777 THR 1778 0.0742

THR 1778 ARG 1779 0.0505

ARG 1779 PRO 1780 0.0570

PRO 1780 ASN 1781 0.0645

ASN 1781 SER 1782 0.0120

SER 1782 SER 1783 0.0741

SER 1783 LEU 1784 0.0385

LEU 1784 LYS 1785 0.0422

LYS 1785 THR 1786 0.0470

THR 1786 GLY 1787 0.0367

GLY 1787 LEU 1788 0.0714

LEU 1788 LEU 1789 -0.0182

LEU 1789 ARG 1790 0.0770

ARG 1790 THR 1791 0.0388

THR 1791 LEU 1792 0.0700

LEU 1792 ARG 1793 0.0162

ARG 1793 LEU 1794 0.0618

LEU 1794 GLU 1795 0.0546

GLU 1795 TYR 1796 0.0346

TYR 1796 THR 1797 0.0263

THR 1797 GLU 1798 0.0593

GLU 1798 LYS 1799 0.0761

LYS 1799 ARG 1800 0.0603

ARG 1800 PHE 1801 0.0460

PHE 1801 ILE 1802 0.0639

ILE 1802 SER 1803 0.0642

SER 1803 LEU 1804 0.0579

LEU 1804 ASP 1805 0.0397

ASP 1805 LEU 1806 0.0759

LEU 1806 ASP 1807 0.0946

ASP 1807 SER 1808 0.0256

SER 1808 ALA 1809 0.0780

ALA 1809 ARG 1810 0.0569

ARG 1810 PRO 1811 0.0924

PRO 1811 GLN 1812 0.0794

GLN 1812 TRP 1813 0.0506

TRP 1813 ASN 1814 0.0184

ASN 1814 HIS 1815 0.0169

HIS 1815 ASP 1816 0.0944

ASP 1816 SER 1817 0.0372

SER 1817 ILE 1818 0.0717

ILE 1818 THR 1819 0.0410

THR 1819 THR 1820 0.0621

THR 1820 ILE 1821 0.0362

ILE 1821 ASN 1822 0.0148

ASN 1822 GLU 1823 0.0489

GLU 1823 VAL 1824 0.0119

VAL 1824 LEU 1825 0.0511

LEU 1825 CYS 1826 0.0084

CYS 1826 GLY 1827 0.0451

GLY 1827 ALA 1828 0.0251

ALA 1828 LEU 1829 0.0288

LEU 1829 ALA 1830 0.0223

ALA 1830 GLN 1831 0.0397

GLN 1831 ASN 1832 0.0465

ASN 1832 ALA 1833 0.0340

ALA 1833 ASP 1834 0.0506

ASP 1834 SER 1835 0.0469

SER 1835 SER 1836 0.0119

SER 1836 ILE 1837 -0.2632

ILE 1837 LYS 1838 0.0496

LYS 1838 ASP 1839 0.0467

ASP 1839 SER 1840 0.0189

SER 1840 GLU 1841 0.0493

GLU 1841 PHE 1842 0.0357

PHE 1842 ALA 1843 0.0517

ALA 1843 GLU 1844 0.0356

GLU 1844 GLN 1845 0.0521

GLN 1845 ASP 1846 0.0315

ASP 1846 GLY 1847 0.0419

GLY 1847 GLN 1848 0.0516

GLN 1848 LEU 1849 0.0427

LEU 1849 PHE 1850 0.0395

PHE 1850 VAL 1851 0.0469

VAL 1851 PRO 1852 0.0248

PRO 1852 ARG 1853 -0.1309

ARG 1853 ILE 1854 0.0274

ILE 1854 SER 1855 0.0051

SER 1855 CYS 1856 0.0239

CYS 1856 ASP 1857 0.0250

ASP 1857 ILE 1858 0.0070

ILE 1858 ALA 1859 0.0238

ALA 1859 ARG 1860 0.0098

ARG 1860 ASN 1861 0.0273

ASN 1861 GLU 1862 0.0019

GLU 1862 ASP 1863 0.0262

ASP 1863 LEU 1864 0.0103

LEU 1864 SER 1865 0.0204

SER 1865 SER 1866 0.0095

SER 1866 ASP 1867 0.0257

ASP 1867 SER 1868 0.0260

SER 1868 ASN 1869 0.0064

ASN 1869 SER 1870 0.0526

SER 1870 PRO 1871 0.0041

PRO 1871 ALA 1872 0.0608

ALA 1872 GLN 1873 0.0425

GLN 1873 MET 1874 0.0359

MET 1874 GLU 1875 0.0547

GLU 1875 PRO 1876 0.0595

PRO 1876 PHE 1877 0.0466

PHE 1877 HIS 1878 0.0621

HIS 1878 GLN 1879 0.0430

GLN 1879 PRO 1880 0.0493

PRO 1880 GLY 1881 0.0018

GLY 1881 LYS 1882 0.0624

LYS 1882 LEU 1883 0.0589

LEU 1883 LEU 1884 0.0464

LEU 1884 GLN 1885 0.1476

GLN 1885 MET 1886 0.0561

MET 1886 GLY 1887 0.0454

GLY 1887 ILE 1888 0.0587

ILE 1888 LYS 1889 0.0594

LYS 1889 THR 1890 0.0561

THR 1890 PRO 1891 0.0452

PRO 1891 GLY 1892 0.0475

GLY 1892 LEU 1893 0.0106

LEU 1893 ILE 1894 0.0516

ILE 1894 ASP 1895 0.0231

ASP 1895 THR 1896 0.0371

THR 1896 LEU 1897 0.0594

LEU 1897 GLN 1898 0.0589

GLN 1898 PHE 1899 0.0572

PHE 1899 SER 1900 0.0438

SER 1900 LYS 1901 0.0637

LYS 1901 THR 1902 0.0209

THR 1902 ASP 1903 0.0601

ASP 1903 ALA 1904 0.0741

ALA 1904 THR 1905 0.0191

THR 1905 ASP 1906 0.0734

ASP 1906 ASN 1907 0.0402

ASN 1907 LEU 1908 0.0703

LEU 1908 PRO 1909 0.0288

PRO 1909 ASN 1910 0.0762

ASN 1910 ASP 1911 0.0736

ASP 1911 TYR 1912 0.0322

TYR 1912 ILE 1913 0.0022

ILE 1913 GLU 1914 0.0461

GLU 1914 ILE 1915 0.0191

ILE 1915 GLU 1916 0.0259

GLU 1916 PRO 1917 0.0660

PRO 1917 LYS 1918 0.0086

LYS 1918 ALA 1919 0.0697

ALA 1919 PHE 1920 0.0274

PHE 1920 GLY 1921 0.0682

GLY 1921 LEU 1922 0.0699

LEU 1922 ASN 1923 0.0295

ASN 1923 PHE 1924 0.0651

PHE 1924 ARG 1925 0.0229

ARG 1925 ASP 1926 0.0564

ASP 1926 VAL 1927 0.0683

VAL 1927 MET 1928 0.0104

MET 1928 VAL 1929 0.0662

VAL 1929 ALA 1930 0.0354

ALA 1930 MET 1931 0.0686

MET 1931 GLY 1932 0.0052

GLY 1932 GLN 1933 0.0142

GLN 1933 LEU 1934 0.0607

LEU 1934 GLU 1935 0.0298

GLU 1935 GLU 1936 0.0586

GLU 1936 SER 1937 0.0393

SER 1937 ILE 1938 0.0542

ILE 1938 MET 1939 0.0046

MET 1939 GLY 1940 0.0390

GLY 1940 PHE 1941 0.0663

PHE 1941 GLU 1942 0.0276

GLU 1942 CYS 1943 0.0264

CYS 1943 ALA 1944 0.0358

ALA 1944 GLY 1945 0.0671

GLY 1945 VAL 1946 0.0718

VAL 1946 VAL 1947 0.0297

VAL 1947 ARG 1948 0.0720

ARG 1948 ARG 1949 0.0508

ARG 1949 VAL 1950 0.0461

VAL 1950 GLY 1951 0.0015

GLY 1951 PRO 1952 0.0684

PRO 1952 SER 1953 0.0701

SER 1953 SER 1954 0.0257

SER 1954 ALA 1955 0.0588

ALA 1955 GLY 1956 0.0648

GLY 1956 HIS 1957 0.0694

HIS 1957 ASN 1958 0.0067

ASN 1958 ILE 1959 0.0765

ILE 1959 LYS 1960 0.0630

LYS 1960 VAL 1961 0.0690

VAL 1961 GLY 1962 0.0105

GLY 1962 ASP 1963 0.0791

ASP 1963 ARG 1964 0.0653

ARG 1964 VAL 1965 0.0738

VAL 1965 CYS 1966 0.0655

CYS 1966 ALA 1967 0.0166

ALA 1967 LEU 1968 0.0431

LEU 1968 LEU 1969 0.0646

LEU 1969 GLY 1970 0.0214

GLY 1970 GLY 1971 0.0456

GLY 1971 GLN 1972 0.0459

GLN 1972 TRP 1973 0.0033

TRP 1973 THR 1974 0.0684

THR 1974 ASN 1975 0.0373

ASN 1975 THR 1976 0.0367

THR 1976 VAL 1977 0.0399

VAL 1977 ARG 1978 0.0160

ARG 1978 VAL 1979 0.0575

VAL 1979 HIS 1980 0.0358

HIS 1980 TRP 1981 0.0694

TRP 1981 HIS 1982 0.0704

HIS 1982 SER 1983 0.0440

SER 1983 VAL 1984 0.0298

VAL 1984 ALA 1985 0.0473

ALA 1985 PRO 1986 0.0286

PRO 1986 ILE 1987 0.0184

ILE 1987 PRO 1988 0.0358

PRO 1988 GLN 1989 0.0419

GLN 1989 ALA 1990 0.0360

ALA 1990 MET 1991 0.0589

MET 1991 ASP 1992 0.0694

ASP 1992 TRP 1993 0.0438

TRP 1993 GLU 1994 0.0732

GLU 1994 THR 1995 0.0724

THR 1995 ALA 1996 0.0303

ALA 1996 ALA 1997 0.0364

ALA 1997 SER 1998 0.0430

SER 1998 ILE 1999 0.0257

ILE 1999 PRO 2000 0.0074

PRO 2000 ILE 2001 0.0364

ILE 2001 VAL 2002 0.0339

VAL 2002 PHE 2003 0.0425

PHE 2003 VAL 2004 0.0069

VAL 2004 THR 2005 0.0409

THR 2005 ALA 2006 0.0370

ALA 2006 TYR 2007 0.0376

TYR 2007 ILE 2008 0.0062

ILE 2008 SER 2009 0.0434

SER 2009 LEU 2010 0.0366

LEU 2010 VAL 2011 0.0418

VAL 2011 LYS 2012 0.0116

LYS 2012 ILE 2013 0.1855

ILE 2013 ALA 2014 0.0257

ALA 2014 ARG 2015 0.0280

ARG 2015 MET 2016 0.0140

MET 2016 GLN 2017 0.0272

GLN 2017 ALA 2018 0.0102

ALA 2018 GLY 2019 0.0286

GLY 2019 GLU 2020 0.0198

GLU 2020 THR 2021 0.0255

THR 2021 VAL 2022 0.0285

VAL 2022 LEU 2023 0.0278

LEU 2023 ILE 2024 0.0226

ILE 2024 HIS 2025 0.0287

HIS 2025 ALA 2026 0.0124

ALA 2026 ALA 2027 0.0225

ALA 2027 SER 2028 0.0067

SER 2028 GLY 2029 -0.0028

GLY 2029 GLY 2030 0.0448

GLY 2030 VAL 2031 0.0078

VAL 2031 GLY 2032 0.0433

GLY 2032 GLN 2033 0.0134

GLN 2033 ALA 2034 0.0361

ALA 2034 ALA 2035 0.0224

ALA 2035 ILE 2036 0.0237

ILE 2036 ILE 2037 0.0371

ILE 2037 LEU 2038 0.0120

LEU 2038 ALA 2039 0.0416

ALA 2039 LYS 2040 0.0130

LYS 2040 HIS 2041 0.0442

HIS 2041 VAL 2042 0.0077

VAL 2042 GLY 2043 0.0387

GLY 2043 ALA 2044 0.0349

ALA 2044 GLU 2045 0.1193

GLU 2045 ILE 2046 0.0371

ILE 2046 PHE 2047 0.0393

PHE 2047 ALA 2048 0.0331

ALA 2048 THR 2049 0.0404

THR 2049 VAL 2050 0.0171

VAL 2050 GLY 2051 0.0391

GLY 2051 THR 2052 0.0070

THR 2052 ASP 2053 0.0258

ASP 2053 GLU 2054 0.0253

GLU 2054 LYS 2055 0.0163

LYS 2055 ARG 2056 0.0384

ARG 2056 ASP 2057 0.0054

ASP 2057 LEU 2058 0.0403

LEU 2058 LEU 2059 0.0145

LEU 2059 ILE 2060 0.0332

ILE 2060 LYS 2061 0.0041

LYS 2061 GLU 2062 0.0383

GLU 2062 TYR 2063 0.0080

TYR 2063 LYS 2064 0.0406

LYS 2064 ILE 2065 0.0102

ILE 2065 PRO 2066 0.0407

PRO 2066 ASP 2067 0.0406

ASP 2067 ASP 2068 0.0110

ASP 2068 HIS 2069 0.0329

HIS 2069 ILE 2070 0.0377

ILE 2070 PHE 2071 0.0296

PHE 2071 SER 2072 0.0408

SER 2072 SER 2073 0.0299

SER 2073 ARG 2074 0.0404

ARG 2074 ASN 2075 0.0257

ASN 2075 ALA 2076 0.0157

ALA 2076 LEU 2077 -0.0305

LEU 2077 PHE 2078 0.0304

PHE 2078 ALA 2079 0.0018

ALA 2079 LYS 2080 0.0310

LYS 2080 SER 2081 0.0079

SER 2081 ILE 2082 0.0283

ILE 2082 ARG 2083 0.0088

ARG 2083 GLN 2084 0.0231

GLN 2084 ARG 2085 0.0211

ARG 2085 THR 2086 0.0127

THR 2086 ASN 2087 0.0253

ASN 2087 GLY 2088 0.0173

GLY 2088 LYS 2089 0.0295

LYS 2089 GLY 2090 0.0257

GLY 2090 VAL 2091 0.0269

VAL 2091 ASP 2092 0.0245

ASP 2092 VAL 2093 0.0242

VAL 2093 VAL 2094 0.0208

VAL 2094 LEU 2095 0.0170

LEU 2095 ASN 2096 0.0210

ASN 2096 CYS 2097 0.0195

CYS 2097 LEU 2098 0.0215

LEU 2098 ALA 2099 0.0109

ALA 2099 GLY 2100 0.0132

GLY 2100 GLY 2101 0.0217

GLY 2101 LEU 2102 0.0096

LEU 2102 LEU 2103 0.0150

LEU 2103 GLN 2104 0.0108

GLN 2104 GLU 2105 0.0123

GLU 2105 SER 2106 0.0192

SER 2106 PHE 2107 0.0023

PHE 2107 ASP 2108 0.0210

ASP 2108 CYS 2109 0.0241

CYS 2109 LEU 2110 0.0115

LEU 2110 ALA 2111 0.0107

ALA 2111 ASP 2112 0.0023

ASP 2112 PHE 2113 0.0134

PHE 2113 GLY 2114 0.0028

GLY 2114 ARG 2115 0.0111

ARG 2115 PHE 2116 0.0117

PHE 2116 ILE 2117 0.0085

ILE 2117 GLU 2118 0.0126

GLU 2118 ILE 2119 0.0049

ILE 2119 GLY 2120 0.0131

GLY 2120 LYS 2121 0.0113

LYS 2121 ARG 2122 0.0133

ARG 2122 ASP 2123 0.0033

ASP 2123 ILE 2124 0.0110

ILE 2124 GLU 2125 0.0413

GLU 2125 LEU 2126 0.0046

LEU 2126 ASN 2127 0.0045

ASN 2127 HIS 2128 0.0053

HIS 2128 CYS 2129 0.0050

CYS 2129 LEU 2130 0.0035

LEU 2130 ASN 2131 0.0056

ASN 2131 MET 2132 0.0050

MET 2132 GLY 2133 0.0053

GLY 2133 MET 2134 0.0008

MET 2134 PHE 2135 0.0050

PHE 2135 ALA 2136 0.0053

ALA 2136 ARG 2137 0.0001

ARG 2137 SER 2138 0.0056

SER 2138 ALA 2139 0.0045

ALA 2139 THR 2140 0.0054

THR 2140 PHE 2141 -0.0758

PHE 2141 THR 2142 0.0402

THR 2142 ALA 2143 0.0400

ALA 2143 VAL 2144 0.0369

VAL 2144 ASP 2145 0.0397

ASP 2145 LEU 2146 0.0375

LEU 2146 ILE 2147 0.0291

ILE 2147 ALA 2148 0.0122

ALA 2148 ILE 2149 0.0381

ILE 2149 GLY 2150 0.0391

GLY 2150 ARG 2151 0.0089

ARG 2151 ASP 2152 0.0269

ASP 2152 ARG 2153 0.0295

ARG 2153 SER 2154 0.0263

SER 2154 TYR 2155 0.0406

TYR 2155 MET 2156 0.0239

MET 2156 PHE 2157 0.0753

PHE 2157 ALA 2158 0.0598

ALA 2158 GLU 2159 0.0597

GLU 2159 ALA 2160 0.0350

ALA 2160 LEU 2161 0.0317

LEU 2161 PRO 2162 0.0579

PRO 2162 LYS 2163 0.0599

LYS 2163 ILE 2164 0.0352

ILE 2164 MET 2165 0.0425

MET 2165 THR 2166 0.0601

THR 2166 LEU 2167 0.0549

LEU 2167 LEU 2168 0.0277

LEU 2168 GLN 2169 0.0560

GLN 2169 GLU 2170 0.0600

GLU 2170 LYS 2171 0.0432

LYS 2171 ALA 2172 0.0321

ALA 2172 ILE 2173 0.0796

ILE 2173 ARG 2174 0.0350

ARG 2174 PRO 2175 0.0629

PRO 2175 VAL 2176 0.0625

VAL 2176 THR 2177 0.0209

THR 2177 PRO 2178 0.0451

PRO 2178 ILE 2179 0.0599

ILE 2179 SER 2180 0.0592

SER 2180 ILE 2181 0.0598

ILE 2181 TYR 2182 0.0625

TYR 2182 LYS 2183 0.0626

LYS 2183 ILE 2184 0.0216

ILE 2184 GLY 2185 0.0486

GLY 2185 ASP 2186 0.0627

ASP 2186 ILE 2187 0.0039

ILE 2187 GLU 2188 0.0612

GLU 2188 THR 2189 0.0464

THR 2189 ALA 2190 0.0551

ALA 2190 PHE 2191 0.0132

PHE 2191 ARG 2192 0.0599

ARG 2192 LEU 2193 0.0538

LEU 2193 MET 2194 0.0185

MET 2194 GLN 2195 0.0501

GLN 2195 ALA 2196 0.0425

ALA 2196 GLY 2197 0.0650

GLY 2197 LYS 2198 0.0031

LYS 2198 HIS 2199 0.0671

HIS 2199 MET 2200 0.0673

MET 2200 GLY 2201 0.0627

GLY 2201 LYS 2202 0.0647

LYS 2202 ILE 2203 0.0633

ILE 2203 VAL 2204 0.0661

VAL 2204 ILE 2205 0.1463

ILE 2205 THR 2206 0.0651

THR 2206 ALA 2207 0.0625

ALA 2207 PRO 2208 0.0432

PRO 2208 GLU 2209 0.0657

GLU 2209 ASP 2210 0.0288

ASP 2210 ALA 2211 0.0612

ALA 2211 MET 2212 0.0674

MET 2212 VAL 2213 0.0450

VAL 2213 PRO 2214 0.0662

PRO 2214 VAL 2215 0.0224

VAL 2215 ILE 2216 0.0501

ILE 2216 THR 2217 0.0490

THR 2217 ARG 2218 0.0176

ARG 2218 PRO 2219 0.0590

PRO 2219 PRO 2220 0.0209

PRO 2220 LYS 2221 0.3537

LYS 2221 LEU 2222 0.0224

LEU 2222 GLN 2223 0.0549

GLN 2223 LEU 2224 0.0183

LEU 2224 ARG 2225 0.0567

ARG 2225 PRO 2226 0.0304

PRO 2226 ASP 2227 0.0563

ASP 2227 ALA 2228 0.0583

ALA 2228 SER 2229 0.0324

SER 2229 TYR 2230 0.0573

TYR 2230 LEU 2231 0.0384

LEU 2231 ILE 2232 0.0590

ILE 2232 VAL 2233 0.0433

VAL 2233 GLY 2234 0.0510

GLY 2234 GLY 2235 0.0580

GLY 2235 LEU 2236 0.0283

LEU 2236 GLY 2237 0.0247

GLY 2237 GLY 2238 0.0230

GLY 2238 ILE 2239 0.0117

ILE 2239 GLY 2240 0.0299

GLY 2240 ARG 2241 0.0358

ARG 2241 SER 2242 0.0040

SER 2242 LEU 2243 0.0343

LEU 2243 CYS 2244 0.0218

CYS 2244 LYS 2245 0.0346

LYS 2245 ASN 2246 0.0031

ASN 2246 PHE 2247 0.0375

PHE 2247 VAL 2248 0.0300

VAL 2248 GLU 2249 0.0185

GLU 2249 ASN 2250 0.0220

ASN 2250 GLY 2251 0.0310

GLY 2251 ALA 2252 0.0162

ALA 2252 ARG 2253 0.1387

ARG 2253 SER 2254 0.0332

SER 2254 LEU 2255 0.0510

LEU 2255 VAL 2256 0.0330

VAL 2256 LEU 2257 0.0478

LEU 2257 LEU 2258 0.0444

LEU 2258 SER 2259 0.0357

SER 2259 ARG 2260 0.0222

ARG 2260 ASN 2261 0.0411

ASN 2261 ALA 2262 0.0510

ALA 2262 ASN 2263 0.0131

ASN 2263 VAL 2264 0.0501

VAL 2264 SER 2265 0.0515

SER 2265 GLN 2266 0.0476

GLN 2266 GLN 2267 0.0280

GLN 2267 SER 2268 0.0266

SER 2268 GLY 2269 0.0112

GLY 2269 GLU 2270 0.0138

GLU 2270 PHE 2271 0.0280

PHE 2271 LEU 2272 0.0355

LEU 2272 ASP 2273 0.0391

ASP 2273 GLU 2274 0.0072

GLU 2274 LEU 2275 0.0382

LEU 2275 ARG 2276 0.0340

ARG 2276 SER 2277 0.0292

SER 2277 THR 2278 0.0139

THR 2278 GLY 2279 0.0351

GLY 2279 CYS 2280 0.0377

CYS 2280 ILE 2281 0.0127

ILE 2281 VAL 2282 0.0295

VAL 2282 GLY 2283 0.0165

GLY 2283 VAL 2284 0.0277

VAL 2284 VAL 2285 -0.1352

VAL 2285 ASP 2286 0.0612

ASP 2286 CYS 2287 0.0482

CYS 2287 ASP 2288 0.0593

ASP 2288 ILE 2289 0.0246

ILE 2289 SER 2290 0.0675

SER 2290 SER 2291 0.0211

SER 2291 LYS 2292 0.0643

LYS 2292 THR 2293 0.0087

THR 2293 GLN 2294 0.0677

GLN 2294 VAL 2295 0.0152

VAL 2295 GLU 2296 0.0614

GLU 2296 ALA 2297 0.0201

ALA 2297 THR 2298 0.0499

THR 2298 MET 2299 0.0403

MET 2299 LEU 2300 0.0300

LEU 2300 ARG 2301 -0.0057

ARG 2301 LEU 2302 0.0161

LEU 2302 LYS 2303 0.0457

LYS 2303 LYS 2304 0.0175

LYS 2304 ASP 2305 0.0506

ASP 2305 MET 2306 0.0069

MET 2306 LEU 2307 0.0112

LEU 2307 PRO 2308 0.0336

PRO 2308 ILE 2309 0.0462

ILE 2309 ARG 2310 0.0011

ARG 2310 GLY 2311 0.0499

GLY 2311 ILE 2312 0.0440

ILE 2312 VAL 2313 0.0506

VAL 2313 HIS 2314 0.0423

HIS 2314 ALA 2315 0.0499

ALA 2315 GLY 2316 0.0211

GLY 2316 MET 2317 0.0136

MET 2317 VAL 2318 0.0785

VAL 2318 LEU 2319 0.0667

LEU 2319 GLN 2320 0.0863

GLN 2320 ASP 2321 0.0402

ASP 2321 SER 2322 0.0819

SER 2322 VAL 2323 0.0217

VAL 2323 PHE 2324 0.0850

PHE 2324 GLU 2325 0.0870

GLU 2325 ARG 2326 0.0120

ARG 2326 MET 2327 0.0815

MET 2327 SER 2328 0.0396

SER 2328 LEU 2329 0.0872

LEU 2329 ASP 2330 0.0333

ASP 2330 ASP 2331 0.0676

ASP 2331 TYR 2332 0.0397

TYR 2332 ASN 2333 -0.1010

ASN 2333 THR 2334 0.0543

THR 2334 ALA 2335 0.0181

ALA 2335 ILE 2336 0.0553

ILE 2336 ARG 2337 0.0249

ARG 2337 PRO 2338 0.0662

PRO 2338 LYS 2339 0.0022

LYS 2339 VAL 2340 0.0660

VAL 2340 GLN 2341 0.0179

GLN 2341 GLY 2342 0.0619

GLY 2342 SER 2343 0.0191

SER 2343 TRP 2344 0.0662

TRP 2344 ASN 2345 0.0065

ASN 2345 LEU 2346 0.0622

LEU 2346 HIS 2347 0.0269

HIS 2347 SER 2348 0.0443

SER 2348 GLY 2349 0.0525

GLY 2349 LEU 2350 0.0306

LEU 2350 SER 2351 0.0342

SER 2351 ASP 2352 0.0415

ASP 2352 CYS 2353 0.0471

CYS 2353 ASP 2354 0.0151

ASP 2354 LEU 2355 0.0473

LEU 2355 ASP 2356 0.0287

ASP 2356 PHE 2357 0.0491

PHE 2357 PHE 2358 0.0440

PHE 2358 ILE 2359 0.0483

ILE 2359 MET 2360 0.0466

MET 2360 LEU 2361 0.0493

LEU 2361 SER 2362 0.0426

SER 2362 SER 2363 0.0455

SER 2363 LEU 2364 0.0138

LEU 2364 ALA 2365 0.1152

ALA 2365 GLY 2366 0.0680

GLY 2366 VAL 2367 0.0091

VAL 2367 SER 2368 0.0642

SER 2368 GLY 2369 0.0513

GLY 2369 SER 2370 0.0443

SER 2370 ALA 2371 0.0682

ALA 2371 SER 2372 0.0119

SER 2372 GLN 2373 0.0666

GLN 2373 ALA 2374 0.0608

ALA 2374 ASN 2375 0.0220

ASN 2375 TYR 2376 0.0690

TYR 2376 THR 2377 0.0025

THR 2377 ALA 2378 0.0680

ALA 2378 GLY 2379 0.0334

GLY 2379 GLY 2380 0.0460

GLY 2380 ALA 2381 0.0569

ALA 2381 TYR 2382 0.0336

TYR 2382 GLN 2383 0.0553

GLN 2383 ASP 2384 0.0014

ASP 2384 ALA 2385 0.0562

ALA 2385 LEU 2386 0.0215

LEU 2386 ALA 2387 0.0476

ALA 2387 LYS 2388 0.0190

LYS 2388 TYR 2389 0.0398

TYR 2389 ARG 2390 0.0423

ARG 2390 ARG 2391 0.0175

ARG 2391 ALA 2392 0.0473

ALA 2392 GLN 2393 0.0212

GLN 2393 GLY 2394 0.0554

GLY 2394 LEU 2395 0.0222

LEU 2395 SER 2396 0.0570

SER 2396 ALA 2397 0.1201

ALA 2397 VAL 2398 0.0465

VAL 2398 SER 2399 0.0503

SER 2399 ILE 2400 0.0518

ILE 2400 ASP 2401 0.0516

ASP 2401 LEU 2402 0.0426

LEU 2402 GLY 2403 0.0487

GLY 2403 MET 2404 0.0343

MET 2404 VAL 2405 0.0432

VAL 2405 GLN 2406 0.0515

GLN 2406 SER 2407 0.0310

SER 2407 VAL 2408 0.0324

VAL 2408 GLY 2409 0.0432

GLY 2409 TYR 2410 0.0512

TYR 2410 VAL 2411 0.0244

VAL 2411 ALA 2412 0.0473

ALA 2412 GLU 2413 0.0745

GLU 2413 THR 2414 0.0491

THR 2414 LYS 2415 0.0460

LYS 2415 GLY 2416 0.0147

GLY 2416 VAL 2417 0.0492

VAL 2417 ALA 2418 0.0306

ALA 2418 GLU 2419 0.0389

GLU 2419 ARG 2420 0.0527

ARG 2420 LEU 2421 0.0471

LEU 2421 VAL 2422 0.0269

VAL 2422 ARG 2423 0.0479

ARG 2423 MET 2424 0.0529

MET 2424 GLY 2425 0.0332

GLY 2425 TYR 2426 0.0307

TYR 2426 SER 2427 0.0519

SER 2427 PRO 2428 0.0204

PRO 2428 ILE 2429 0.0412

ILE 2429 SER 2430 0.0302

SER 2430 GLU 2431 0.0206

GLU 2431 MET 2432 0.0168

MET 2432 GLU 2433 0.0210

GLU 2433 VAL 2434 0.0180

VAL 2434 LEU 2435 0.0345

LEU 2435 LYS 2436 0.0013

LYS 2436 ILE 2437 0.0351

ILE 2437 VAL 2438 0.0152

VAL 2438 GLU 2439 0.0308

GLU 2439 HIS 2440 0.0073

HIS 2440 ALA 2441 0.0292

ALA 2441 ILE 2442 0.0300

ILE 2442 THR 2443 0.0126

THR 2443 ASN 2444 0.0179

ASN 2444 PRO 2445 -0.1245

PRO 2445 PRO 2446 0.0184

PRO 2446 PRO 2447 0.0377

PRO 2447 GLU 2448 0.0383

GLU 2448 ALA 2449 0.0278

ALA 2449 SER 2450 0.0191

SER 2450 SER 2451 0.0401

SER 2451 ALA 2452 0.0013

ALA 2452 GLN 2453 0.0391

GLN 2453 ILE 2454 0.0385

ILE 2454 ILE 2455 0.0359

ILE 2455 THR 2456 0.0399

THR 2456 GLY 2457 0.0396

GLY 2457 ILE 2458 0.0096

ILE 2458 SER 2459 0.0245

SER 2459 THR 2460 0.0069

THR 2460 LYS 2461 -0.0547

LYS 2461 PRO 2462 0.0222

PRO 2462 GLY 2463 0.0180

GLY 2463 ARG 2464 0.0244

ARG 2464 HIS 2465 0.0169

HIS 2465 TRP 2466 0.0147

TRP 2466 THR 2467 0.0293

THR 2467 GLU 2468 0.0029

GLU 2468 SER 2469 0.0229

SER 2469 SER 2470 0.0287

SER 2470 TRP 2471 0.0289

TRP 2471 LEU 2472 0.0067

LEU 2472 GLN 2473 0.0247

GLN 2473 ASP 2474 0.0262

ASP 2474 ALA 2475 0.0141

ALA 2475 ARG 2476 0.0245

ARG 2476 PHE 2477 0.1247

PHE 2477 ALA 2478 0.0100

ALA 2478 THR 2479 0.0188

THR 2479 LEU 2480 0.0232

LEU 2480 ARG 2481 0.0200

ARG 2481 GLU 2482 0.0071

GLU 2482 ARG 2483 0.0229

ARG 2483 ALA 2484 0.0231

ALA 2484 ARG 2485 0.0127

ARG 2485 ASP 2486 0.0149

ASP 2486 VAL 2487 0.0232

VAL 2487 LYS 2488 0.0215

LYS 2488 GLU 2489 0.0099

GLU 2489 LEU 2490 0.0208

LEU 2490 SER 2491 0.0229

SER 2491 ASN 2492 0.0142

ASN 2492 SER 2493 0.1556

SER 2493 GLN 2494 0.0586

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** sdgklnrdh ***

CA strain for 22101813491974862

--- normal mode 24 ---

Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *