Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *

CA strain for 22101813491974862

--- normal mode 21 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
ASN 989 LYS 990 0.0220

LYS 990 ALA 991 0.0031

ALA 991 HIS 992 0.0201

HIS 992 ARG 993 0.0115

ARG 993 GLN 994 0.0138

GLN 994 ARG 995 0.0105

ARG 995 VAL 996 0.0182

VAL 996 HIS 997 0.0152

HIS 997 PRO 998 0.0199

PRO 998 PRO 999 0.0170

PRO 999 HIS 1000 0.0059

HIS 1000 ASP 1001 0.0195

ASP 1001 LEU 1002 0.0044

LEU 1002 LEU 1003 0.0217

LEU 1003 GLY 1004 0.0033

GLY 1004 SER 1005 -0.0851

SER 1005 LEU 1006 0.0179

LEU 1006 ILE 1007 0.0177

ILE 1007 VAL 1008 0.0116

VAL 1008 GLY 1009 0.0192

GLY 1009 ARG 1010 0.0005

ARG 1010 ASP 1011 0.0120

ASP 1011 LEU 1012 0.0181

LEU 1012 ARG 1013 0.0034

ARG 1013 GLU 1014 0.0199

GLU 1014 PRO 1015 0.0123

PRO 1015 THR 1016 0.0188

THR 1016 TRP 1017 0.0166

TRP 1017 ARG 1018 0.0145

ARG 1018 HIS 1019 0.0199

HIS 1019 PHE 1020 0.0151

PHE 1020 ILE 1021 0.0892

ILE 1021 ARG 1022 0.0133

ARG 1022 VAL 1023 0.0066

VAL 1023 GLN 1024 0.0076

GLN 1024 ASP 1025 0.0091

ASP 1025 ILE 1026 0.0054

ILE 1026 PRO 1027 0.0065

PRO 1027 TRP 1028 0.0082

TRP 1028 ILE 1029 0.0127

ILE 1029 ARG 1030 0.0091

ARG 1030 ASP 1031 0.0080

ASP 1031 HIS 1032 0.0129

HIS 1032 VAL 1033 0.0085

VAL 1033 VAL 1034 0.0091

VAL 1034 GLN 1035 0.0083

GLN 1035 SER 1036 0.0110

SER 1036 ALA 1037 0.0876

ALA 1037 LEU 1038 0.0063

LEU 1038 VAL 1039 0.0123

VAL 1039 TYR 1040 0.0079

TYR 1040 PRO 1041 0.0073

PRO 1041 GLY 1042 0.0116

GLY 1042 ALA 1043 0.0116

ALA 1043 GLY 1044 0.0013

GLY 1044 PHE 1045 0.0121

PHE 1045 ILE 1046 0.0115

ILE 1046 CYS 1047 0.0075

CYS 1047 MET 1048 0.0059

MET 1048 ALA 1049 0.0120

ALA 1049 MET 1050 0.0123

MET 1050 GLU 1051 0.0039

GLU 1051 ALA 1052 0.0106

ALA 1052 MET 1053 0.0965

MET 1053 VAL 1054 0.0101

VAL 1054 GLN 1055 0.0015

GLN 1055 LEU 1056 0.0111

LEU 1056 HIS 1057 0.0104

HIS 1057 GLU 1058 0.0042

GLU 1058 LEU 1059 0.0077

LEU 1059 ARG 1060 0.0095

ARG 1060 ASP 1061 0.0103

ASP 1061 SER 1062 0.0071

SER 1062 GLN 1063 0.0040

GLN 1063 SER 1064 0.0093

SER 1064 ARG 1065 0.0016

ARG 1065 LYS 1066 0.0088

LYS 1066 VAL 1067 0.0098

VAL 1067 ALA 1068 0.0006

ALA 1068 GLY 1069 0.0520

GLY 1069 TYR 1070 0.0114

TYR 1070 ARG 1071 0.0058

ARG 1071 LEU 1072 0.0106

LEU 1072 ALA 1073 0.0069

ALA 1073 GLU 1074 0.0097

GLU 1074 VAL 1075 0.0105

VAL 1075 ASP 1076 0.0107

ASP 1076 ILE 1077 0.0115

ILE 1077 LEU 1078 0.0116

LEU 1078 ARG 1079 0.0111

ARG 1079 ALA 1080 0.0113

ALA 1080 MET 1081 0.0010

MET 1081 LEU 1082 0.0115

LEU 1082 ILE 1083 0.0053

ILE 1083 PRO 1084 0.0100

PRO 1084 ASP 1085 -0.0459

ASP 1085 THR 1086 0.0044

THR 1086 SER 1087 0.0069

SER 1087 GLU 1088 0.0164

GLU 1088 GLY 1089 0.0013

GLY 1089 LEU 1090 0.0097

LEU 1090 GLU 1091 0.0172

GLU 1091 ALA 1092 0.0056

ALA 1092 HIS 1093 0.0168

HIS 1093 ILE 1094 0.0096

ILE 1094 SER 1095 0.0168

SER 1095 LEU 1096 0.0122

LEU 1096 ARG 1097 0.0151

ARG 1097 PRO 1098 0.0126

PRO 1098 CYS 1099 0.0018

CYS 1099 SER 1100 0.0169

SER 1100 THR 1101 -0.1168

THR 1101 LYS 1102 0.0049

LYS 1102 LEU 1103 0.0099

LEU 1103 LEU 1104 0.0062

LEU 1104 LEU 1105 0.0083

LEU 1105 THR 1106 0.0105

THR 1106 ASN 1107 0.0033

ASN 1107 GLU 1108 0.0024

GLU 1108 TRP 1109 0.0107

TRP 1109 TYR 1110 0.0059

TYR 1110 ASP 1111 0.0108

ASP 1111 PHE 1112 0.0070

PHE 1112 CYS 1113 0.0101

CYS 1113 VAL 1114 0.0083

VAL 1114 SER 1115 0.0085

SER 1115 SER 1116 0.0052

SER 1116 VAL 1117 -0.0163

VAL 1117 GLY 1118 0.0123

GLY 1118 ASP 1119 0.0051

ASP 1119 ASP 1120 0.0118

ASP 1120 ASP 1121 0.0121

ASP 1121 LYS 1122 0.0006

LYS 1122 PHE 1123 0.0092

PHE 1123 VAL 1124 0.0041

VAL 1124 ASP 1125 0.0072

ASP 1125 HIS 1126 0.0108

HIS 1126 CYS 1127 0.0095

CYS 1127 ARG 1128 0.0112

ARG 1128 GLY 1129 0.0094

GLY 1129 ARG 1130 0.0124

ARG 1130 ILE 1131 0.0103

ILE 1131 THR 1132 0.0123

THR 1132 ILE 1133 0.0479

ILE 1133 GLU 1134 0.0041

GLU 1134 PHE 1135 -0.0000

PHE 1135 ASP 1136 0.0035

ASP 1136 THR 1137 0.0043

THR 1137 SER 1138 0.0017

SER 1138 GLY 1139 0.0039

GLY 1139 SER 1140 0.0002

SER 1140 ALA 1141 0.0043

ALA 1141 ASP 1142 0.0018

ASP 1142 THR 1143 0.0010

THR 1143 PRO 1144 0.0041

PRO 1144 ARG 1145 0.0022

ARG 1145 THR 1146 0.0027

THR 1146 SER 1147 0.0046

SER 1147 LEU 1148 0.0012

LEU 1148 ARG 1149 -0.1768

ARG 1149 GLU 1150 0.0157

GLU 1150 ARG 1151 0.0114

ARG 1151 SER 1152 0.0063

SER 1152 ARG 1153 0.0147

ARG 1153 SER 1154 0.0070

SER 1154 THR 1155 0.0026

THR 1155 GLY 1156 0.0092

GLY 1156 LEU 1157 0.0114

LEU 1157 MET 1158 0.0136

MET 1158 ARG 1159 0.0097

ARG 1159 SER 1160 0.0146

SER 1160 VAL 1161 0.0157

VAL 1161 ASP 1162 0.0156

ASP 1162 PRO 1163 0.0082

PRO 1163 SER 1164 0.0101

SER 1164 ASN 1165 0.1101

ASN 1165 LEU 1166 0.0040

LEU 1166 TYR 1167 0.0107

TYR 1167 SER 1168 0.0023

SER 1168 PHE 1169 0.0121

PHE 1169 LEU 1170 0.0015

LEU 1170 ARG 1171 0.0115

ARG 1171 ALA 1172 0.0042

ALA 1172 GLN 1173 0.0077

GLN 1173 GLY 1174 0.0077

GLY 1174 ILE 1175 0.0065

ILE 1175 TYR 1176 0.0122

TYR 1176 HIS 1177 0.0084

HIS 1177 GLY 1178 0.0121

GLY 1178 PRO 1179 0.0120

PRO 1179 ILE 1180 0.0005

ILE 1180 PHE 1181 0.0224

PHE 1181 GLN 1182 0.0042

GLN 1182 ASN 1183 0.0102

ASN 1183 LEU 1184 0.0077

LEU 1184 LYS 1185 0.0106

LYS 1185 THR 1186 0.0098

THR 1186 ILE 1187 0.0119

ILE 1187 SER 1188 0.0117

SER 1188 SER 1189 0.0123

SER 1189 ARG 1190 0.0112

ARG 1190 LYS 1191 0.0128

LYS 1191 ASP 1192 0.0010

ASP 1192 HIS 1193 0.0098

HIS 1193 SER 1194 0.0129

SER 1194 GLU 1195 0.0105

GLU 1195 SER 1196 0.0124

SER 1196 SER 1197 -0.0546

SER 1197 PHE 1198 0.0078

PHE 1198 VAL 1199 0.0073

VAL 1199 VAL 1200 0.0011

VAL 1200 ALA 1201 0.0144

ALA 1201 ASN 1202 0.0088

ASN 1202 THR 1203 0.0115

THR 1203 ALA 1204 0.0055

ALA 1204 SER 1205 0.0097

SER 1205 VAL 1206 0.0145

VAL 1206 MET 1207 0.0009

MET 1207 PRO 1208 0.0084

PRO 1208 ASN 1209 0.0132

ASN 1209 GLY 1210 0.0102

GLY 1210 PHE 1211 0.0069

PHE 1211 GLN 1212 0.0139

GLN 1212 SER 1213 0.0420

SER 1213 PRO 1214 0.0126

PRO 1214 HIS 1215 0.0072

HIS 1215 VAL 1216 0.0102

VAL 1216 ILE 1217 0.0027

ILE 1217 HIS 1218 0.0122

HIS 1218 PRO 1219 0.0092

PRO 1219 THR 1220 0.0072

THR 1220 THR 1221 0.0129

THR 1221 LEU 1222 0.0130

LEU 1222 ASP 1223 0.0083

ASP 1223 SER 1224 0.0087

SER 1224 ILE 1225 0.0126

ILE 1225 PHE 1226 0.0121

PHE 1226 GLN 1227 0.0077

GLN 1227 GLY 1228 0.0112

GLY 1228 ALA 1229 -0.0349

ALA 1229 TYR 1230 0.0015

TYR 1230 THR 1231 0.0104

THR 1231 ALA 1232 0.0116

ALA 1232 LEU 1233 0.0075

LEU 1233 PRO 1234 0.0011

PRO 1234 GLY 1235 0.0085

GLY 1235 ALA 1236 0.0025

ALA 1236 GLY 1237 0.0116

GLY 1237 LEU 1238 0.0029

LEU 1238 ASP 1239 0.0103

ASP 1239 GLN 1240 0.0059

GLN 1240 ASN 1241 0.0111

ASN 1241 THR 1242 0.0028

THR 1242 ALA 1243 0.0052

ALA 1243 MET 1244 0.0044

MET 1244 ILE 1245 0.0943

ILE 1245 PRO 1246 0.0067

PRO 1246 ARG 1247 0.0105

ARG 1247 SER 1248 0.0090

SER 1248 ILE 1249 0.0100

ILE 1249 GLN 1250 0.0106

GLN 1250 GLU 1251 0.0074

GLU 1251 LEU 1252 0.0098

LEU 1252 TYR 1253 0.0077

TYR 1253 LEU 1254 0.0092

LEU 1254 SER 1255 0.0089

SER 1255 SER 1256 0.0033

SER 1256 ALA 1257 0.0081

ALA 1257 LEU 1258 0.0077

LEU 1258 THR 1259 0.0097

THR 1259 SER 1260 0.0109

SER 1260 ASP 1261 0.0318

ASP 1261 VAL 1262 0.0066

VAL 1262 GLY 1263 0.0016

GLY 1263 GLN 1264 0.0115

GLN 1264 CYS 1265 0.0037

CYS 1265 LEU 1266 0.0117

LEU 1266 VAL 1267 0.0057

VAL 1267 SER 1268 0.0116

SER 1268 ASP 1269 0.0088

ASP 1269 THR 1270 0.0111

THR 1270 SER 1271 0.0101

SER 1271 LEU 1272 0.0101

LEU 1272 ILE 1273 0.0101

ILE 1273 ARG 1274 0.0096

ARG 1274 TYR 1275 0.0079

TYR 1275 ASP 1276 0.0100

ASP 1276 GLY 1277 0.0874

GLY 1277 GLN 1278 0.0042

GLN 1278 SER 1279 0.0050

SER 1279 PHE 1280 0.0102

PHE 1280 THR 1281 0.0048

THR 1281 VAL 1282 0.0100

VAL 1282 ASN 1283 0.0058

ASN 1283 VAL 1284 0.0094

VAL 1284 ASP 1285 0.0085

ASP 1285 VAL 1286 0.0095

VAL 1286 SER 1287 0.0098

SER 1287 SER 1288 0.0099

SER 1288 LYS 1289 0.0037

LYS 1289 ALA 1290 0.0062

ALA 1290 ASP 1291 0.0092

ASP 1291 SER 1292 0.0075

SER 1292 GLU 1293 0.0188

GLU 1293 HIS 1294 0.0096

HIS 1294 THR 1295 0.0028

THR 1295 PRO 1296 0.0105

PRO 1296 VAL 1297 0.0058

VAL 1297 LEU 1298 0.0097

LEU 1298 GLU 1299 0.0088

GLU 1299 ILE 1300 0.0090

ILE 1300 LYS 1301 0.0096

LYS 1301 GLY 1302 0.0080

GLY 1302 LEU 1303 0.0101

LEU 1303 ARG 1304 0.0082

ARG 1304 ASN 1305 0.0078

ASN 1305 GLN 1306 0.0095

GLN 1306 SER 1307 0.0060

SER 1307 VAL 1308 0.0089

VAL 1308 GLY 1309 0.3268

GLY 1309 GLN 1310 0.0032

GLN 1310 MET 1311 0.0136

MET 1311 ALA 1312 0.0185

ALA 1312 PRO 1313 0.0129

PRO 1313 GLN 1314 0.0189

GLN 1314 PRO 1315 0.0145

PRO 1315 GLY 1316 0.0213

GLY 1316 ASP 1317 0.0157

ASP 1317 SER 1318 0.0308

SER 1318 SER 1319 0.0315

SER 1319 ASN 1320 0.0062

ASN 1320 ASN 1321 0.0283

ASN 1321 ASP 1322 0.0036

ASP 1322 LEU 1323 0.0312

LEU 1323 CYS 1324 0.0231

CYS 1324 PHE 1325 0.1842

PHE 1325 LYS 1326 0.0010

LYS 1326 LEU 1327 0.0014

LEU 1327 ASP 1328 0.0052

ASP 1328 TRP 1329 0.0011

TRP 1329 ALA 1330 0.0051

ALA 1330 PRO 1331 0.0023

PRO 1331 ASP 1332 0.0054

ASP 1332 ILE 1333 0.0049

ILE 1333 SER 1334 0.0038

SER 1334 SER 1335 0.0015

SER 1335 VAL 1336 0.0052

VAL 1336 LYS 1337 0.0026

LYS 1337 GLN 1338 0.0050

GLN 1338 GLU 1339 0.0036

GLU 1339 ARG 1340 0.0039

ARG 1340 LEU 1341 0.4544

LEU 1341 LYS 1342 0.0421

LYS 1342 GLU 1343 0.0430

GLU 1343 LYS 1344 0.0123

LYS 1344 PHE 1345 0.0370

PHE 1345 GLY 1346 0.0362

GLY 1346 PHE 1347 0.0298

PHE 1347 PRO 1348 0.0403

PRO 1348 LEU 1349 0.0426

LEU 1349 ASP 1350 0.0093

ASP 1350 PRO 1351 0.0432

PRO 1351 THR 1352 0.0065

THR 1352 GLU 1353 0.0414

GLU 1353 ALA 1354 0.0123

ALA 1354 ASP 1355 0.0309

ASP 1355 ILE 1356 0.0269

ILE 1356 ILE 1357 -0.1983

ILE 1357 MET 1358 0.1022

MET 1358 GLY 1359 0.0281

GLY 1359 LEU 1360 0.0837

LEU 1360 ARG 1361 0.0515

ARG 1361 GLN 1362 0.0562

GLN 1362 ALA 1363 0.0774

ALA 1363 CYS 1364 0.0338

CYS 1364 ILE 1365 0.0987

ILE 1365 HIS 1366 0.0166

HIS 1366 PHE 1367 0.1025

PHE 1367 ILE 1368 0.0179

ILE 1368 HIS 1369 0.0969

HIS 1369 ARG 1370 0.0384

ARG 1370 SER 1371 0.0782

SER 1371 LEU 1372 0.0490

LEU 1372 GLN 1373 0.1168

GLN 1373 SER 1374 0.0904

SER 1374 LEU 1375 0.0364

LEU 1375 THR 1376 0.1097

THR 1376 ALA 1377 0.0237

ALA 1377 PRO 1378 0.1086

PRO 1378 ASP 1379 0.1040

ASP 1379 ARG 1380 0.0275

ARG 1380 ASP 1381 0.0821

ASP 1381 GLN 1382 0.0909

GLN 1382 LEU 1383 0.1075

LEU 1383 ASP 1384 0.0817

ASP 1384 TRP 1385 0.0248

TRP 1385 HIS 1386 0.0966

HIS 1386 GLN 1387 0.0447

GLN 1387 LYS 1388 0.0671

LYS 1388 ARG 1389 0.1314

ARG 1389 PHE 1390 0.0194

PHE 1390 TYR 1391 0.1091

TYR 1391 ASP 1392 0.0348

ASP 1392 TRP 1393 0.1027

TRP 1393 MET 1394 0.0220

MET 1394 VAL 1395 0.0924

VAL 1395 LEU 1396 0.0764

LEU 1396 GLN 1397 0.0435

GLN 1397 ILE 1398 0.0909

ILE 1398 GLN 1399 0.0357

GLN 1399 LEU 1400 0.1108

LEU 1400 ALA 1401 0.0084

ALA 1401 GLU 1402 0.1080

GLU 1402 GLU 1403 0.0462

GLU 1403 ASP 1404 0.0778

ASP 1404 ARG 1405 0.1190

ARG 1405 LEU 1406 0.0663

LEU 1406 ALA 1407 0.0931

ALA 1407 PRO 1408 0.1125

PRO 1408 ASN 1409 0.0812

ASN 1409 SER 1410 0.1142

SER 1410 SER 1411 0.1140

SER 1411 ALA 1412 0.0116

ALA 1412 TRP 1413 0.1089

TRP 1413 LEU 1414 0.1123

LEU 1414 GLN 1415 0.0581

GLN 1415 CYS 1416 0.0540

CYS 1416 SER 1417 0.0147

SER 1417 SER 1418 0.0970

SER 1418 SER 1419 0.0653

SER 1419 ASP 1420 0.0606

ASP 1420 GLU 1421 0.0800

GLU 1421 GLN 1422 0.0457

GLN 1422 LYS 1423 0.1068

LYS 1423 LEU 1424 0.0050

LEU 1424 LEU 1425 0.1083

LEU 1425 GLU 1426 0.0401

GLU 1426 ASN 1427 0.0911

ASN 1427 VAL 1428 0.0274

VAL 1428 ARG 1429 0.0870

ARG 1429 ALA 1430 0.0825

ALA 1430 SER 1431 0.0469

SER 1431 SER 1432 0.0713

SER 1432 VAL 1433 0.1041

VAL 1433 ASN 1434 0.0544

ASN 1434 GLY 1435 0.0575

GLY 1435 GLN 1436 0.0781

GLN 1436 MET 1437 0.0254

MET 1437 VAL 1438 0.0943

VAL 1438 VAL 1439 0.0159

VAL 1439 HIS 1440 0.1004

HIS 1440 VAL 1441 0.0283

VAL 1441 GLY 1442 0.1025

GLY 1442 LYS 1443 0.0217

LYS 1443 SER 1444 0.0935

SER 1444 MET 1445 0.0161

MET 1445 LEU 1446 0.1006

LEU 1446 ALA 1447 0.0856

ALA 1447 ILE 1448 0.0419

ILE 1448 LEU 1449 0.0631

LEU 1449 ARG 1450 0.0759

ARG 1450 HIS 1451 0.1021

HIS 1451 GLU 1452 0.0016

GLU 1452 ILE 1453 0.0177

ILE 1453 ALA 1454 0.0503

ALA 1454 PRO 1455 0.0871

PRO 1455 LEU 1456 0.0945

LEU 1456 GLU 1457 0.0166

GLU 1457 LEU 1458 0.0844

LEU 1458 MET 1459 0.0731

MET 1459 LEU 1460 0.0884

LEU 1460 GLN 1461 0.0078

GLN 1461 ASP 1462 0.0765

ASP 1462 LYS 1463 0.0272

LYS 1463 LEU 1464 0.0891

LEU 1464 LEU 1465 0.0086

LEU 1465 TYR 1466 0.0964

TYR 1466 ARG 1467 0.0817

ARG 1467 TYR 1468 0.0504

TYR 1468 TYR 1469 -0.0190

TYR 1469 THR 1470 0.0313

THR 1470 ASP 1471 0.0273

ASP 1471 ALA 1472 0.0304

ALA 1472 ILE 1473 0.0309

ILE 1473 LYS 1474 0.0048

LYS 1474 TRP 1475 0.0373

TRP 1475 ASP 1476 0.0347

ASP 1476 ARG 1477 0.0160

ARG 1477 SER 1478 0.0203

SER 1478 TYR 1479 0.0320

TYR 1479 GLN 1480 0.0372

GLN 1480 GLN 1481 0.0030

GLN 1481 ILE 1482 0.0366

ILE 1482 ASP 1483 0.0284

ASP 1483 GLN 1484 0.0230

GLN 1484 LEU 1485 0.0609

LEU 1485 VAL 1486 0.0066

VAL 1486 LYS 1487 0.0075

LYS 1487 LEU 1488 0.0005

LEU 1488 HIS 1489 0.0073

HIS 1489 ALA 1490 0.0054

ALA 1490 HIS 1491 0.0064

HIS 1491 LYS 1492 0.0012

LYS 1492 CYS 1493 0.0075

CYS 1493 PRO 1494 0.0027

PRO 1494 THR 1495 0.0075

THR 1495 ALA 1496 0.0078

ALA 1496 LYS 1497 0.0071

LYS 1497 ILE 1498 0.0054

ILE 1498 ILE 1499 0.0066

ILE 1499 GLU 1500 0.0042

GLU 1500 ILE 1501 -0.0426

ILE 1501 GLY 1502 0.0070

GLY 1502 ALA 1503 0.0112

ALA 1503 GLY 1504 0.0091

GLY 1504 THR 1505 0.0047

THR 1505 GLY 1506 0.0163

GLY 1506 GLY 1507 0.0194

GLY 1507 CYS 1508 0.0041

CYS 1508 THR 1509 0.0194

THR 1509 ARG 1510 0.0087

ARG 1510 ALA 1511 0.0145

ALA 1511 VAL 1512 0.0074

VAL 1512 LEU 1513 0.0143

LEU 1513 ASP 1514 0.0152

ASP 1514 ALA 1515 0.0037

ALA 1515 LEU 1516 0.0173

LEU 1516 SER 1517 0.0237

SER 1517 ASN 1518 0.0127

ASN 1518 GLN 1519 0.0012

GLN 1519 GLY 1520 0.0125

GLY 1520 ILE 1521 0.0026

ILE 1521 ALA 1522 0.0076

ALA 1522 ARG 1523 0.0016

ARG 1523 CYS 1524 0.0104

CYS 1524 ALA 1525 0.0116

ALA 1525 GLN 1526 0.0112

GLN 1526 TYR 1527 0.0104

TYR 1527 ASP 1528 0.0127

ASP 1528 PHE 1529 0.0059

PHE 1529 THR 1530 0.0117

THR 1530 ASP 1531 0.0114

ASP 1531 VAL 1532 0.0122

VAL 1532 SER 1533 0.0240

SER 1533 SER 1534 0.0149

SER 1534 GLY 1535 0.0089

GLY 1535 PHE 1536 0.0218

PHE 1536 PHE 1537 0.0211

PHE 1537 GLU 1538 0.0017

GLU 1538 ALA 1539 0.0205

ALA 1539 ALA 1540 0.0074

ALA 1540 GLN 1541 0.0211

GLN 1541 GLN 1542 0.0036

GLN 1542 LYS 1543 0.0188

LYS 1543 PHE 1544 0.0108

PHE 1544 ALA 1545 0.0178

ALA 1545 ALA 1546 0.0206

ALA 1546 PHE 1547 0.0020

PHE 1547 ASP 1548 0.0215

ASP 1548 ASP 1549 -0.1848

ASP 1549 VAL 1550 0.0100

VAL 1550 ILE 1551 0.0245

ILE 1551 ARG 1552 0.0271

ARG 1552 PHE 1553 0.0230

PHE 1553 GLN 1554 0.0214

GLN 1554 LYS 1555 0.0270

LYS 1555 LEU 1556 0.0051

LEU 1556 ASP 1557 0.0242

ASP 1557 ILE 1558 0.0052

ILE 1558 GLU 1559 0.0247

GLU 1559 LYS 1560 0.0269

LYS 1560 ASP 1561 0.0177

ASP 1561 ILE 1562 0.0258

ILE 1562 GLU 1563 0.0267

GLU 1563 MET 1564 0.0169

MET 1564 GLN 1565 0.0045

GLN 1565 GLY 1566 0.0264

GLY 1566 PHE 1567 0.0242

PHE 1567 GLU 1568 0.0112

GLU 1568 CYS 1569 0.0113

CYS 1569 GLY 1570 0.0244

GLY 1570 SER 1571 0.0095

SER 1571 TYR 1572 0.0189

TYR 1572 ASP 1573 0.0263

ASP 1573 LEU 1574 0.0179

LEU 1574 VAL 1575 0.0254

VAL 1575 ILE 1576 0.0110

ILE 1576 ALA 1577 0.0261

ALA 1577 SER 1578 0.0131

SER 1578 GLN 1579 0.0263

GLN 1579 VAL 1580 0.0233

VAL 1580 LEU 1581 0.0357

LEU 1581 HIS 1582 0.0352

HIS 1582 ALA 1583 0.0316

ALA 1583 THR 1584 0.0082

THR 1584 GLY 1585 0.0170

GLY 1585 LYS 1586 0.0142

LYS 1586 MET 1587 0.0349

MET 1587 GLU 1588 0.0085

GLU 1588 HIS 1589 0.0339

HIS 1589 THR 1590 0.0046

THR 1590 MET 1591 0.0318

MET 1591 ALA 1592 0.0169

ALA 1592 ASN 1593 0.0169

ASN 1593 VAL 1594 0.0247

VAL 1594 ARG 1595 0.0138

ARG 1595 LYS 1596 0.0353

LYS 1596 LEU 1597 0.0665

LEU 1597 LEU 1598 0.0342

LEU 1598 LYS 1599 0.0250

LYS 1599 PRO 1600 0.0156

PRO 1600 GLY 1601 0.0307

GLY 1601 GLY 1602 0.0072

GLY 1602 LYS 1603 0.0235

LYS 1603 LEU 1604 0.0322

LEU 1604 LEU 1605 0.0105

LEU 1605 LEU 1606 0.0357

LEU 1606 VAL 1607 0.0136

VAL 1607 GLU 1608 0.0362

GLU 1608 THR 1609 0.0352

THR 1609 THR 1610 0.0151

THR 1610 ARG 1611 0.0302

ARG 1611 ASP 1612 0.0215

ASP 1612 GLU 1613 -0.0222

GLU 1613 MET 1614 0.0722

MET 1614 ASP 1615 0.0388

ASP 1615 LEU 1616 0.0580

LEU 1616 GLN 1617 0.0614

GLN 1617 LEU 1618 0.0351

LEU 1618 VAL 1619 0.0748

VAL 1619 PHE 1620 0.0323

PHE 1620 GLY 1621 0.0668

GLY 1621 LEU 1622 0.0628

LEU 1622 LEU 1623 0.0742

LEU 1623 PRO 1624 0.0223

PRO 1624 GLY 1625 0.0806

GLY 1625 TRP 1626 0.0894

TRP 1626 TRP 1627 0.0463

TRP 1627 LEU 1628 0.0543

LEU 1628 SER 1629 0.1923

SER 1629 SER 1630 0.0146

SER 1630 GLU 1631 0.0583

GLU 1631 GLU 1632 0.0649

GLU 1632 GLU 1633 0.0546

GLU 1633 ARG 1634 0.0234

ARG 1634 GLN 1635 0.0650

GLN 1635 MET 1636 0.0370

MET 1636 SER 1637 0.0561

SER 1637 PRO 1638 0.0663

PRO 1638 SER 1639 0.0660

SER 1639 LEU 1640 0.0277

LEU 1640 SER 1641 0.0657

SER 1641 THR 1642 0.0656

THR 1642 ASN 1643 0.0070

ASN 1643 SER 1644 0.0648

SER 1644 TRP 1645 0.1756

TRP 1645 GLU 1646 0.0192

GLU 1646 LYS 1647 0.0160

LYS 1647 VAL 1648 0.0305

VAL 1648 LEU 1649 0.0333

LEU 1649 LYS 1650 0.0051

LYS 1650 LYS 1651 0.0293

LYS 1651 THR 1652 0.0262

THR 1652 GLY 1653 0.0311

GLY 1653 PHE 1654 0.0199

PHE 1654 ASP 1655 0.0314

ASP 1655 GLY 1656 0.0210

GLY 1656 LEU 1657 0.0050

LEU 1657 ASP 1658 0.0330

ASP 1658 ILE 1659 0.0048

ILE 1659 GLU 1660 0.0247

GLU 1660 LEU 1661 -0.0503

LEU 1661 ARG 1662 0.0395

ARG 1662 ASP 1663 0.0010

ASP 1663 CYS 1664 0.0513

CYS 1664 ASP 1665 0.0292

ASP 1665 SER 1666 0.0514

SER 1666 ASP 1667 0.0250

ASP 1667 GLU 1668 0.0272

GLU 1668 PHE 1669 0.0239

PHE 1669 TYR 1670 0.0434

TYR 1670 SER 1671 0.0513

SER 1671 PHE 1672 0.0508

PHE 1672 SER 1673 0.0231

SER 1673 VAL 1674 0.0514

VAL 1674 MET 1675 0.0058

MET 1675 MET 1676 0.0409

MET 1676 ALA 1677 -0.1152

ALA 1677 THR 1678 0.0249

THR 1678 ALA 1679 0.0283

ALA 1679 SER 1680 0.0030

SER 1680 SER 1681 0.0255

SER 1681 THR 1682 0.0111

THR 1682 ILE 1683 0.0195

ILE 1683 ALA 1684 0.0253

ALA 1684 SER 1685 0.0014

SER 1685 SER 1686 0.0283

SER 1686 SER 1687 0.0058

SER 1687 MET 1688 0.0276

MET 1688 ALA 1689 0.0125

ALA 1689 PHE 1690 0.0281

PHE 1690 ALA 1691 0.0246

ALA 1691 ILE 1692 0.0283

ILE 1692 VAL 1693 0.1406

VAL 1693 TYR 1694 0.0612

TYR 1694 GLY 1695 0.0480

GLY 1695 GLU 1696 0.0552

GLU 1696 VAL 1697 0.0566

VAL 1697 PRO 1698 0.0290

PRO 1698 LEU 1699 0.0606

LEU 1699 PRO 1700 0.0410

PRO 1700 ASP 1701 0.0187

ASP 1701 GLN 1702 0.0611

GLN 1702 PHE 1703 0.0097

PHE 1703 LEU 1704 0.0554

LEU 1704 ASP 1705 0.0282

ASP 1705 ASP 1706 0.0404

ASP 1706 MET 1707 0.0374

MET 1707 LYS 1708 0.0314

LYS 1708 THR 1709 0.0135

THR 1709 ALA 1710 0.0042

ALA 1710 ILE 1711 0.0548

ILE 1711 SER 1712 0.0151

SER 1712 SER 1713 0.0524

SER 1713 SER 1714 0.0161

SER 1714 ALA 1715 0.0491

ALA 1715 VAL 1716 0.0234

VAL 1716 SER 1717 0.0503

SER 1717 ASP 1718 0.0510

ASP 1718 PRO 1719 0.0347

PRO 1719 VAL 1720 0.0510

VAL 1720 VAL 1721 0.0537

VAL 1721 GLY 1722 0.0545

GLY 1722 HIS 1723 0.0433

HIS 1723 LEU 1724 0.0186

LEU 1724 ASP 1725 0.0448

ASP 1725 SER 1726 0.0149

SER 1726 ILE 1727 0.0622

ILE 1727 ASP 1728 0.0636

ASP 1728 ALA 1729 0.0263

ALA 1729 THR 1730 0.0627

THR 1730 GLY 1731 0.0632

GLY 1731 LYS 1732 0.0634

LYS 1732 PHE 1733 0.0349

PHE 1733 CYS 1734 0.0625

CYS 1734 ILE 1735 0.0601

ILE 1735 PHE 1736 0.0572

PHE 1736 ILE 1737 0.0635

ILE 1737 GLU 1738 0.0502

GLU 1738 ASP 1739 0.0624

ASP 1739 PRO 1740 0.0202

PRO 1740 GLU 1741 0.1724

GLU 1741 THR 1742 0.0778

THR 1742 ASP 1743 0.0267

ASP 1743 ILE 1744 0.0653

ILE 1744 LEU 1745 0.0221

LEU 1745 SER 1746 0.0540

SER 1746 SER 1747 0.0626

SER 1747 PRO 1748 0.0384

PRO 1748 ASP 1749 0.0484

ASP 1749 GLU 1750 0.0742

GLU 1750 LYS 1751 0.0188

LYS 1751 SER 1752 0.0712

SER 1752 TYR 1753 0.0304

TYR 1753 ALA 1754 0.0530

ALA 1754 SER 1755 0.0490

SER 1755 ILE 1756 0.0331

ILE 1756 GLN 1757 0.0104

GLN 1757 LYS 1758 0.0095

LYS 1758 LEU 1759 0.0672

LEU 1759 VAL 1760 0.0207

VAL 1760 THR 1761 0.0655

THR 1761 ARG 1762 0.0070

ARG 1762 CYS 1763 0.0674

CYS 1763 LYS 1764 0.0668

LYS 1764 GLY 1765 0.0457

GLY 1765 LEU 1766 0.0653

LEU 1766 ILE 1767 0.0648

ILE 1767 TRP 1768 0.0589

TRP 1768 VAL 1769 0.0669

VAL 1769 SER 1770 0.0418

SER 1770 ARG 1771 0.0597

ARG 1771 GLY 1772 0.0075

GLY 1772 GLY 1773 -0.0014

GLY 1773 ALA 1774 0.0642

ALA 1774 MET 1775 0.0604

MET 1775 HIS 1776 0.0690

HIS 1776 GLY 1777 0.0729

GLY 1777 THR 1778 0.0565

THR 1778 ARG 1779 0.0646

ARG 1779 PRO 1780 0.0383

PRO 1780 ASN 1781 0.0481

ASN 1781 SER 1782 0.0479

SER 1782 SER 1783 0.0334

SER 1783 LEU 1784 0.0737

LEU 1784 LYS 1785 0.0332

LYS 1785 THR 1786 0.0550

THR 1786 GLY 1787 0.0331

GLY 1787 LEU 1788 0.0430

LEU 1788 LEU 1789 0.0664

LEU 1789 ARG 1790 0.0150

ARG 1790 THR 1791 0.0698

THR 1791 LEU 1792 0.0083

LEU 1792 ARG 1793 0.0694

ARG 1793 LEU 1794 0.0358

LEU 1794 GLU 1795 0.0510

GLU 1795 TYR 1796 0.0233

TYR 1796 THR 1797 0.0653

THR 1797 GLU 1798 0.0100

GLU 1798 LYS 1799 0.0609

LYS 1799 ARG 1800 0.0705

ARG 1800 PHE 1801 0.0632

PHE 1801 ILE 1802 0.0707

ILE 1802 SER 1803 0.0643

SER 1803 LEU 1804 0.0585

LEU 1804 ASP 1805 -0.0480

ASP 1805 LEU 1806 0.0425

LEU 1806 ASP 1807 0.0510

ASP 1807 SER 1808 0.0579

SER 1808 ALA 1809 0.0598

ALA 1809 ARG 1810 0.0065

ARG 1810 PRO 1811 0.0189

PRO 1811 GLN 1812 0.0566

GLN 1812 TRP 1813 0.0138

TRP 1813 ASN 1814 0.0594

ASN 1814 HIS 1815 0.0514

HIS 1815 ASP 1816 0.0093

ASP 1816 SER 1817 0.0571

SER 1817 ILE 1818 0.0200

ILE 1818 THR 1819 0.0555

THR 1819 THR 1820 0.0105

THR 1820 ILE 1821 -0.0015

ILE 1821 ASN 1822 0.0177

ASN 1822 GLU 1823 0.0113

GLU 1823 VAL 1824 0.0159

VAL 1824 LEU 1825 0.0126

LEU 1825 CYS 1826 0.0252

CYS 1826 GLY 1827 0.0008

GLY 1827 ALA 1828 0.0256

ALA 1828 LEU 1829 0.0120

LEU 1829 ALA 1830 0.0244

ALA 1830 GLN 1831 0.0056

GLN 1831 ASN 1832 0.0255

ASN 1832 ALA 1833 0.0131

ALA 1833 ASP 1834 0.0093

ASP 1834 SER 1835 0.0235

SER 1835 SER 1836 0.0102

SER 1836 ILE 1837 0.1340

ILE 1837 LYS 1838 0.0167

LYS 1838 ASP 1839 0.0293

ASP 1839 SER 1840 0.0288

SER 1840 GLU 1841 0.0270

GLU 1841 PHE 1842 0.0223

PHE 1842 ALA 1843 0.0293

ALA 1843 GLU 1844 0.0178

GLU 1844 GLN 1845 0.0248

GLN 1845 ASP 1846 0.0207

ASP 1846 GLY 1847 0.0142

GLY 1847 GLN 1848 0.0195

GLN 1848 LEU 1849 0.0272

LEU 1849 PHE 1850 0.0011

PHE 1850 VAL 1851 0.0219

VAL 1851 PRO 1852 0.0040

PRO 1852 ARG 1853 0.0077

ARG 1853 ILE 1854 0.0076

ILE 1854 SER 1855 0.0092

SER 1855 CYS 1856 0.0007

CYS 1856 ASP 1857 0.0204

ASP 1857 ILE 1858 0.0121

ILE 1858 ALA 1859 0.0210

ALA 1859 ARG 1860 0.0258

ARG 1860 ASN 1861 0.0239

ASN 1861 GLU 1862 0.0127

GLU 1862 ASP 1863 0.0241

ASP 1863 LEU 1864 0.0259

LEU 1864 SER 1865 0.0197

SER 1865 SER 1866 0.0162

SER 1866 ASP 1867 0.0135

ASP 1867 SER 1868 0.0253

SER 1868 ASN 1869 -0.2259

ASN 1869 SER 1870 0.1106

SER 1870 PRO 1871 0.1302

PRO 1871 ALA 1872 0.0980

ALA 1872 GLN 1873 0.0851

GLN 1873 MET 1874 0.1184

MET 1874 GLU 1875 0.1298

GLU 1875 PRO 1876 0.1081

PRO 1876 PHE 1877 0.0137

PHE 1877 HIS 1878 0.1293

HIS 1878 GLN 1879 0.0806

GLN 1879 PRO 1880 0.1302

PRO 1880 GLY 1881 0.1266

GLY 1881 LYS 1882 0.1285

LYS 1882 LEU 1883 0.0283

LEU 1883 LEU 1884 0.1287

LEU 1884 GLN 1885 0.1062

GLN 1885 MET 1886 0.0496

MET 1886 GLY 1887 0.0568

GLY 1887 ILE 1888 0.0573

ILE 1888 LYS 1889 0.0298

LYS 1889 THR 1890 0.0367

THR 1890 PRO 1891 0.0011

PRO 1891 GLY 1892 0.0500

GLY 1892 LEU 1893 0.0258

LEU 1893 ILE 1894 0.0566

ILE 1894 ASP 1895 0.0110

ASP 1895 THR 1896 0.0507

THR 1896 LEU 1897 0.0526

LEU 1897 GLN 1898 0.0232

GLN 1898 PHE 1899 0.0543

PHE 1899 SER 1900 0.0445

SER 1900 LYS 1901 0.1905

LYS 1901 THR 1902 0.1068

THR 1902 ASP 1903 0.1229

ASP 1903 ALA 1904 0.1160

ALA 1904 THR 1905 0.1199

THR 1905 ASP 1906 0.1308

ASP 1906 ASN 1907 0.0507

ASN 1907 LEU 1908 0.0403

LEU 1908 PRO 1909 0.0590

PRO 1909 ASN 1910 0.0933

ASN 1910 ASP 1911 0.0512

ASP 1911 TYR 1912 0.0991

TYR 1912 ILE 1913 0.1244

ILE 1913 GLU 1914 0.0537

GLU 1914 ILE 1915 0.1289

ILE 1915 GLU 1916 0.0787

GLU 1916 PRO 1917 0.0463

PRO 1917 LYS 1918 0.0835

LYS 1918 ALA 1919 0.0610

ALA 1919 PHE 1920 0.0779

PHE 1920 GLY 1921 0.0377

GLY 1921 LEU 1922 0.0783

LEU 1922 ASN 1923 0.0539

ASN 1923 PHE 1924 0.0811

PHE 1924 ARG 1925 0.0787

ARG 1925 ASP 1926 0.0128

ASP 1926 VAL 1927 0.0831

VAL 1927 MET 1928 0.0733

MET 1928 VAL 1929 0.0475

VAL 1929 ALA 1930 0.0405

ALA 1930 MET 1931 0.0765

MET 1931 GLY 1932 0.0834

GLY 1932 GLN 1933 -0.0219

GLN 1933 LEU 1934 0.0835

LEU 1934 GLU 1935 0.0827

GLU 1935 GLU 1936 0.0880

GLU 1936 SER 1937 0.0263

SER 1937 ILE 1938 0.0821

ILE 1938 MET 1939 0.0904

MET 1939 GLY 1940 0.0854

GLY 1940 PHE 1941 0.0169

PHE 1941 GLU 1942 0.0881

GLU 1942 CYS 1943 0.0722

CYS 1943 ALA 1944 0.0893

ALA 1944 GLY 1945 0.0520

GLY 1945 VAL 1946 0.0856

VAL 1946 VAL 1947 0.0904

VAL 1947 ARG 1948 0.0135

ARG 1948 ARG 1949 0.1219

ARG 1949 VAL 1950 0.0511

VAL 1950 GLY 1951 0.1221

GLY 1951 PRO 1952 0.1174

PRO 1952 SER 1953 0.0131

SER 1953 SER 1954 0.1198

SER 1954 ALA 1955 0.1173

ALA 1955 GLY 1956 0.0337

GLY 1956 HIS 1957 0.0910

HIS 1957 ASN 1958 0.1189

ASN 1958 ILE 1959 0.0561

ILE 1959 LYS 1960 0.0354

LYS 1960 VAL 1961 0.0240

VAL 1961 GLY 1962 0.1222

GLY 1962 ASP 1963 0.0088

ASP 1963 ARG 1964 0.1154

ARG 1964 VAL 1965 0.1727

VAL 1965 CYS 1966 0.0948

CYS 1966 ALA 1967 0.1063

ALA 1967 LEU 1968 0.0963

LEU 1968 LEU 1969 0.0422

LEU 1969 GLY 1970 0.1043

GLY 1970 GLY 1971 0.0881

GLY 1971 GLN 1972 0.0194

GLN 1972 TRP 1973 0.0913

TRP 1973 THR 1974 0.0602

THR 1974 ASN 1975 0.0842

ASN 1975 THR 1976 0.0975

THR 1976 VAL 1977 0.0249

VAL 1977 ARG 1978 0.0972

ARG 1978 VAL 1979 0.0042

VAL 1979 HIS 1980 0.0634

HIS 1980 TRP 1981 0.0880

TRP 1981 HIS 1982 0.0216

HIS 1982 SER 1983 0.1000

SER 1983 VAL 1984 0.1030

VAL 1984 ALA 1985 0.0784

ALA 1985 PRO 1986 0.1027

PRO 1986 ILE 1987 0.1082

ILE 1987 PRO 1988 0.0964

PRO 1988 GLN 1989 0.0537

GLN 1989 ALA 1990 0.1009

ALA 1990 MET 1991 0.1084

MET 1991 ASP 1992 0.0411

ASP 1992 TRP 1993 0.0841

TRP 1993 GLU 1994 0.1008

GLU 1994 THR 1995 0.0053

THR 1995 ALA 1996 0.1067

ALA 1996 ALA 1997 0.0752

ALA 1997 SER 1998 0.0529

SER 1998 ILE 1999 0.0473

ILE 1999 PRO 2000 0.0753

PRO 2000 ILE 2001 0.0815

ILE 2001 VAL 2002 0.0457

VAL 2002 PHE 2003 0.0377

PHE 2003 VAL 2004 0.0784

VAL 2004 THR 2005 0.0831

THR 2005 ALA 2006 0.0182

ALA 2006 TYR 2007 0.0700

TYR 2007 ILE 2008 0.0757

ILE 2008 SER 2009 0.0784

SER 2009 LEU 2010 0.0166

LEU 2010 VAL 2011 0.0755

VAL 2011 LYS 2012 0.0696

LYS 2012 ILE 2013 0.3131

ILE 2013 ALA 2014 0.0226

ALA 2014 ARG 2015 0.0239

ARG 2015 MET 2016 0.0320

MET 2016 GLN 2017 0.0017

GLN 2017 ALA 2018 0.0217

ALA 2018 GLY 2019 0.0400

GLY 2019 GLU 2020 0.0138

GLU 2020 THR 2021 0.0356

THR 2021 VAL 2022 0.0042

VAL 2022 LEU 2023 0.0248

LEU 2023 ILE 2024 0.0232

ILE 2024 HIS 2025 0.0150

HIS 2025 ALA 2026 0.0344

ALA 2026 ALA 2027 0.0148

ALA 2027 SER 2028 0.0408

SER 2028 GLY 2029 0.0122

GLY 2029 GLY 2030 0.0721

GLY 2030 VAL 2031 0.0647

VAL 2031 GLY 2032 0.0407

GLY 2032 GLN 2033 0.0636

GLN 2033 ALA 2034 0.0720

ALA 2034 ALA 2035 0.0555

ALA 2035 ILE 2036 0.0421

ILE 2036 ILE 2037 0.0710

ILE 2037 LEU 2038 0.0708

LEU 2038 ALA 2039 0.0488

ALA 2039 LYS 2040 0.0492

LYS 2040 HIS 2041 0.0721

HIS 2041 VAL 2042 0.0653

VAL 2042 GLY 2043 0.0409

GLY 2043 ALA 2044 0.0616

ALA 2044 GLU 2045 -0.0696

GLU 2045 ILE 2046 0.0196

ILE 2046 PHE 2047 0.0521

PHE 2047 ALA 2048 0.0167

ALA 2048 THR 2049 0.0297

THR 2049 VAL 2050 0.0419

VAL 2050 GLY 2051 0.0311

GLY 2051 THR 2052 0.0559

THR 2052 ASP 2053 0.0219

ASP 2053 GLU 2054 0.0547

GLU 2054 LYS 2055 0.0608

LYS 2055 ARG 2056 0.0093

ARG 2056 ASP 2057 0.0548

ASP 2057 LEU 2058 0.0526

LEU 2058 LEU 2059 0.0452

LEU 2059 ILE 2060 0.0171

ILE 2060 LYS 2061 0.1083

LYS 2061 GLU 2062 0.0541

GLU 2062 TYR 2063 0.0609

TYR 2063 LYS 2064 0.0171

LYS 2064 ILE 2065 0.0588

ILE 2065 PRO 2066 0.0435

PRO 2066 ASP 2067 0.0511

ASP 2067 ASP 2068 0.0607

ASP 2068 HIS 2069 0.0482

HIS 2069 ILE 2070 0.0172

ILE 2070 PHE 2071 0.0394

PHE 2071 SER 2072 0.0113

SER 2072 SER 2073 0.0287

SER 2073 ARG 2074 0.0441

ARG 2074 ASN 2075 0.0495

ASN 2075 ALA 2076 0.0534

ALA 2076 LEU 2077 0.0666

LEU 2077 PHE 2078 0.0330

PHE 2078 ALA 2079 0.0404

ALA 2079 LYS 2080 0.0287

LYS 2080 SER 2081 0.0279

SER 2081 ILE 2082 0.0395

ILE 2082 ARG 2083 0.0380

ARG 2083 GLN 2084 0.0253

GLN 2084 ARG 2085 0.0340

ARG 2085 THR 2086 0.0403

THR 2086 ASN 2087 0.0327

ASN 2087 GLY 2088 0.0136

GLY 2088 LYS 2089 0.0407

LYS 2089 GLY 2090 0.0146

GLY 2090 VAL 2091 0.0398

VAL 2091 ASP 2092 0.0402

ASP 2092 VAL 2093 -0.0455

VAL 2093 VAL 2094 0.0036

VAL 2094 LEU 2095 0.0228

LEU 2095 ASN 2096 0.0048

ASN 2096 CYS 2097 0.0069

CYS 2097 LEU 2098 0.0271

LEU 2098 ALA 2099 0.0151

ALA 2099 GLY 2100 0.0304

GLY 2100 GLY 2101 0.0243

GLY 2101 LEU 2102 0.0194

LEU 2102 LEU 2103 0.0299

LEU 2103 GLN 2104 0.0312

GLN 2104 GLU 2105 0.0243

GLU 2105 SER 2106 0.0249

SER 2106 PHE 2107 0.0318

PHE 2107 ASP 2108 0.0294

ASP 2108 CYS 2109 0.0019

CYS 2109 LEU 2110 0.0265

LEU 2110 ALA 2111 0.0060

ALA 2111 ASP 2112 0.0313

ASP 2112 PHE 2113 0.0345

PHE 2113 GLY 2114 0.0260

GLY 2114 ARG 2115 0.0255

ARG 2115 PHE 2116 0.0037

PHE 2116 ILE 2117 0.0307

ILE 2117 GLU 2118 0.0009

GLU 2118 ILE 2119 0.0312

ILE 2119 GLY 2120 0.0063

GLY 2120 LYS 2121 0.0161

LYS 2121 ARG 2122 0.0175

ARG 2122 ASP 2123 0.0326

ASP 2123 ILE 2124 0.0326

ILE 2124 GLU 2125 0.0549

GLU 2125 LEU 2126 0.0037

LEU 2126 ASN 2127 0.0096

ASN 2127 HIS 2128 0.0101

HIS 2128 CYS 2129 0.0103

CYS 2129 LEU 2130 0.0030

LEU 2130 ASN 2131 0.0104

ASN 2131 MET 2132 0.0079

MET 2132 GLY 2133 0.0100

GLY 2133 MET 2134 0.0029

MET 2134 PHE 2135 0.0088

PHE 2135 ALA 2136 0.0105

ALA 2136 ARG 2137 0.0046

ARG 2137 SER 2138 0.0078

SER 2138 ALA 2139 0.0102

ALA 2139 THR 2140 0.0101

THR 2140 PHE 2141 0.0031

PHE 2141 THR 2142 0.0415

THR 2142 ALA 2143 0.0014

ALA 2143 VAL 2144 0.0594

VAL 2144 ASP 2145 0.0068

ASP 2145 LEU 2146 0.0628

LEU 2146 ILE 2147 0.0196

ILE 2147 ALA 2148 0.0511

ALA 2148 ILE 2149 0.0349

ILE 2149 GLY 2150 0.0341

GLY 2150 ARG 2151 0.0538

ARG 2151 ASP 2152 0.0251

ASP 2152 ARG 2153 0.0303

ARG 2153 SER 2154 0.0542

SER 2154 TYR 2155 0.0222

TYR 2155 MET 2156 0.0564

MET 2156 PHE 2157 0.1953

PHE 2157 ALA 2158 0.0885

ALA 2158 GLU 2159 0.0022

GLU 2159 ALA 2160 0.0885

ALA 2160 LEU 2161 0.0449

LEU 2161 PRO 2162 0.0836

PRO 2162 LYS 2163 0.0071

LYS 2163 ILE 2164 0.0840

ILE 2164 MET 2165 0.0666

MET 2165 THR 2166 0.0366

THR 2166 LEU 2167 0.0591

LEU 2167 LEU 2168 0.0524

LEU 2168 GLN 2169 0.0881

GLN 2169 GLU 2170 0.0010

GLU 2170 LYS 2171 0.0887

LYS 2171 ALA 2172 0.0533

ALA 2172 ILE 2173 0.1088

ILE 2173 ARG 2174 0.0405

ARG 2174 PRO 2175 0.0171

PRO 2175 VAL 2176 0.0751

VAL 2176 THR 2177 0.0733

THR 2177 PRO 2178 0.0346

PRO 2178 ILE 2179 0.0287

ILE 2179 SER 2180 0.0333

SER 2180 ILE 2181 0.0236

ILE 2181 TYR 2182 0.0163

TYR 2182 LYS 2183 0.0184

LYS 2183 ILE 2184 0.0632

ILE 2184 GLY 2185 0.0365

GLY 2185 ASP 2186 0.0439

ASP 2186 ILE 2187 0.0648

ILE 2187 GLU 2188 0.0744

GLU 2188 THR 2189 0.1677

THR 2189 ALA 2190 0.0390

ALA 2190 PHE 2191 0.0830

PHE 2191 ARG 2192 0.0843

ARG 2192 LEU 2193 0.0292

LEU 2193 MET 2194 0.0675

MET 2194 GLN 2195 0.0748

GLN 2195 ALA 2196 0.0738

ALA 2196 GLY 2197 0.0198

GLY 2197 LYS 2198 0.0834

LYS 2198 HIS 2199 0.0827

HIS 2199 MET 2200 0.0208

MET 2200 GLY 2201 0.0818

GLY 2201 LYS 2202 0.0323

LYS 2202 ILE 2203 0.0028

ILE 2203 VAL 2204 0.0690

VAL 2204 ILE 2205 0.3160

ILE 2205 THR 2206 0.0872

THR 2206 ALA 2207 0.0379

ALA 2207 PRO 2208 0.0887

PRO 2208 GLU 2209 0.0345

GLU 2209 ASP 2210 0.0914

ASP 2210 ALA 2211 0.0922

ALA 2211 MET 2212 0.0850

MET 2212 VAL 2213 0.1073

VAL 2213 PRO 2214 0.1057

PRO 2214 VAL 2215 0.1108

VAL 2215 ILE 2216 0.1096

ILE 2216 THR 2217 0.0786

THR 2217 ARG 2218 0.1156

ARG 2218 PRO 2219 0.0480

PRO 2219 PRO 2220 0.1203

PRO 2220 LYS 2221 1.0720

LYS 2221 LEU 2222 0.1210

LEU 2222 GLN 2223 0.0837

GLN 2223 LEU 2224 0.1275

LEU 2224 ARG 2225 0.1164

ARG 2225 PRO 2226 0.0758

PRO 2226 ASP 2227 0.1322

ASP 2227 ALA 2228 0.0114

ALA 2228 SER 2229 0.0984

SER 2229 TYR 2230 0.0824

TYR 2230 LEU 2231 0.0584

LEU 2231 ILE 2232 0.1205

ILE 2232 VAL 2233 0.0453

VAL 2233 GLY 2234 0.1371

GLY 2234 GLY 2235 0.0065

GLY 2235 LEU 2236 0.1347

LEU 2236 GLY 2237 -0.1259

GLY 2237 GLY 2238 0.1081

GLY 2238 ILE 2239 0.1052

ILE 2239 GLY 2240 0.1028

GLY 2240 ARG 2241 0.0206

ARG 2241 SER 2242 0.1144

SER 2242 LEU 2243 0.1078

LEU 2243 CYS 2244 0.0564

CYS 2244 LYS 2245 0.0645

LYS 2245 ASN 2246 0.1012

ASN 2246 PHE 2247 0.1143

PHE 2247 VAL 2248 0.0138

VAL 2248 GLU 2249 0.1060

GLU 2249 ASN 2250 0.0882

ASN 2250 GLY 2251 0.0909

GLY 2251 ALA 2252 0.0912

ALA 2252 ARG 2253 0.1898

ARG 2253 SER 2254 0.0732

SER 2254 LEU 2255 0.0684

LEU 2255 VAL 2256 0.0677

VAL 2256 LEU 2257 0.1189

LEU 2257 LEU 2258 0.0347

LEU 2258 SER 2259 0.1284

SER 2259 ARG 2260 0.0924

ARG 2260 ASN 2261 0.0746

ASN 2261 ALA 2262 0.0391

ALA 2262 ASN 2263 0.1213

ASN 2263 VAL 2264 0.1392

VAL 2264 SER 2265 0.0249

SER 2265 GLN 2266 0.1277

GLN 2266 GLN 2267 0.1183

GLN 2267 SER 2268 0.1381

SER 2268 GLY 2269 0.0950

GLY 2269 GLU 2270 0.1198

GLU 2270 PHE 2271 0.0958

PHE 2271 LEU 2272 0.1515

LEU 2272 ASP 2273 0.0009

ASP 2273 GLU 2274 0.1517

GLU 2274 LEU 2275 0.1149

LEU 2275 ARG 2276 0.1063

ARG 2276 SER 2277 0.0530

SER 2277 THR 2278 0.1395

THR 2278 GLY 2279 0.1517

GLY 2279 CYS 2280 0.0013

CYS 2280 ILE 2281 0.1322

ILE 2281 VAL 2282 0.0890

VAL 2282 GLY 2283 0.0960

GLY 2283 VAL 2284 0.1148

VAL 2284 VAL 2285 -0.0262

VAL 2285 ASP 2286 0.0658

ASP 2286 CYS 2287 0.0502

CYS 2287 ASP 2288 0.0286

ASP 2288 ILE 2289 0.1320

ILE 2289 SER 2290 0.0090

SER 2290 SER 2291 0.1374

SER 2291 LYS 2292 0.1376

LYS 2292 THR 2293 0.1185

THR 2293 GLN 2294 0.0576

GLN 2294 VAL 2295 0.1347

VAL 2295 GLU 2296 0.1375

GLU 2296 ALA 2297 0.0909

ALA 2297 THR 2298 0.0909

THR 2298 MET 2299 0.1376

MET 2299 LEU 2300 0.1327

LEU 2300 ARG 2301 0.0136

ARG 2301 LEU 2302 0.1164

LEU 2302 LYS 2303 0.1270

LYS 2303 LYS 2304 0.0740

LYS 2304 ASP 2305 0.0964

ASP 2305 MET 2306 0.1269

MET 2306 LEU 2307 0.1241

LEU 2307 PRO 2308 0.0481

PRO 2308 ILE 2309 0.0773

ILE 2309 ARG 2310 0.1265

ARG 2310 GLY 2311 0.1031

GLY 2311 ILE 2312 0.0834

ILE 2312 VAL 2313 0.1218

VAL 2313 HIS 2314 0.0544

HIS 2314 ALA 2315 0.1256

ALA 2315 GLY 2316 0.0975

GLY 2316 MET 2317 0.1106

MET 2317 VAL 2318 0.0651

VAL 2318 LEU 2319 0.0834

LEU 2319 GLN 2320 0.0300

GLN 2320 ASP 2321 0.0885

ASP 2321 SER 2322 0.0119

SER 2322 VAL 2323 0.0568

VAL 2323 PHE 2324 0.0627

PHE 2324 GLU 2325 0.0348

GLU 2325 ARG 2326 0.0743

ARG 2326 MET 2327 0.0692

MET 2327 SER 2328 0.0858

SER 2328 LEU 2329 0.0927

LEU 2329 ASP 2330 0.0394

ASP 2330 ASP 2331 0.0664

ASP 2331 TYR 2332 0.0882

TYR 2332 ASN 2333 0.0352

ASN 2333 THR 2334 0.0250

THR 2334 ALA 2335 0.0920

ALA 2335 ILE 2336 0.0888

ILE 2336 ARG 2337 0.0939

ARG 2337 PRO 2338 0.0077

PRO 2338 LYS 2339 0.0987

LYS 2339 VAL 2340 0.0335

VAL 2340 GLN 2341 0.1016

GLN 2341 GLY 2342 0.0007

GLY 2342 SER 2343 0.0995

SER 2343 TRP 2344 0.0566

TRP 2344 ASN 2345 0.0864

ASN 2345 LEU 2346 0.0228

LEU 2346 HIS 2347 0.0863

HIS 2347 SER 2348 0.0852

SER 2348 GLY 2349 0.0698

GLY 2349 LEU 2350 0.0741

LEU 2350 SER 2351 0.0826

SER 2351 ASP 2352 0.0442

ASP 2352 CYS 2353 0.0663

CYS 2353 ASP 2354 0.0993

ASP 2354 LEU 2355 0.1069

LEU 2355 ASP 2356 0.0892

ASP 2356 PHE 2357 0.0695

PHE 2357 PHE 2358 0.0488

PHE 2358 ILE 2359 0.1045

ILE 2359 MET 2360 0.0533

MET 2360 LEU 2361 0.1068

LEU 2361 SER 2362 0.0054

SER 2362 SER 2363 0.0960

SER 2363 LEU 2364 0.0920

LEU 2364 ALA 2365 0.0982

ALA 2365 GLY 2366 0.0664

GLY 2366 VAL 2367 0.0926

VAL 2367 SER 2368 0.0926

SER 2368 GLY 2369 0.0623

GLY 2369 SER 2370 0.0837

SER 2370 ALA 2371 0.0632

ALA 2371 SER 2372 0.0916

SER 2372 GLN 2373 0.0814

GLN 2373 ALA 2374 0.0293

ALA 2374 ASN 2375 0.0871

ASN 2375 TYR 2376 0.0112

TYR 2376 THR 2377 0.0862

THR 2377 ALA 2378 0.0529

ALA 2378 GLY 2379 0.0458

GLY 2379 GLY 2380 0.0621

GLY 2380 ALA 2381 0.0438

ALA 2381 TYR 2382 0.0893

TYR 2382 GLN 2383 0.0070

GLN 2383 ASP 2384 0.0884

ASP 2384 ALA 2385 0.0361

ALA 2385 LEU 2386 0.0696

LEU 2386 ALA 2387 0.0402

ALA 2387 LYS 2388 0.0537

LYS 2388 TYR 2389 0.0739

TYR 2389 ARG 2390 0.0234

ARG 2390 ARG 2391 0.0836

ARG 2391 ALA 2392 0.0204

ALA 2392 GLN 2393 0.0867

GLN 2393 GLY 2394 0.0212

GLY 2394 LEU 2395 0.0691

LEU 2395 SER 2396 0.0456

SER 2396 ALA 2397 0.0693

ALA 2397 VAL 2398 0.0766

VAL 2398 SER 2399 0.0575

SER 2399 ILE 2400 0.0622

ILE 2400 ASP 2401 0.0441

ASP 2401 LEU 2402 0.0391

LEU 2402 GLY 2403 0.0762

GLY 2403 MET 2404 0.0652

MET 2404 VAL 2405 0.0061

VAL 2405 GLN 2406 0.0584

GLN 2406 SER 2407 0.0211

SER 2407 VAL 2408 0.0723

VAL 2408 GLY 2409 0.0331

GLY 2409 TYR 2410 0.0253

TYR 2410 VAL 2411 0.0763

VAL 2411 ALA 2412 0.0063

ALA 2412 GLU 2413 0.1454

GLU 2413 THR 2414 0.0212

THR 2414 LYS 2415 0.0755

LYS 2415 GLY 2416 0.0439

GLY 2416 VAL 2417 0.0702

VAL 2417 ALA 2418 0.0524

ALA 2418 GLU 2419 0.0673

GLU 2419 ARG 2420 0.0090

ARG 2420 LEU 2421 0.0741

LEU 2421 VAL 2422 0.0624

VAL 2422 ARG 2423 0.0304

ARG 2423 MET 2424 0.0504

MET 2424 GLY 2425 0.0595

GLY 2425 TYR 2426 0.0455

TYR 2426 SER 2427 0.0112

SER 2427 PRO 2428 0.0311

PRO 2428 ILE 2429 0.1062

ILE 2429 SER 2430 0.0065

SER 2430 GLU 2431 0.0509

GLU 2431 MET 2432 0.0430

MET 2432 GLU 2433 0.0198

GLU 2433 VAL 2434 0.0420

VAL 2434 LEU 2435 0.0278

LEU 2435 LYS 2436 0.0556

LYS 2436 ILE 2437 0.0007

ILE 2437 VAL 2438 0.0556

VAL 2438 GLU 2439 0.0235

GLU 2439 HIS 2440 0.0418

HIS 2440 ALA 2441 0.0200

ALA 2441 ILE 2442 0.0374

ILE 2442 THR 2443 0.0437

THR 2443 ASN 2444 0.0257

ASN 2444 PRO 2445 0.2451

PRO 2445 PRO 2446 0.0191

PRO 2446 PRO 2447 0.0559

PRO 2447 GLU 2448 0.0024

GLU 2448 ALA 2449 0.0455

ALA 2449 SER 2450 0.0545

SER 2450 SER 2451 0.0085

SER 2451 ALA 2452 0.0590

ALA 2452 GLN 2453 0.0614

GLN 2453 ILE 2454 0.0313

ILE 2454 ILE 2455 0.0574

ILE 2455 THR 2456 0.0316

THR 2456 GLY 2457 0.0609

GLY 2457 ILE 2458 0.0357

ILE 2458 SER 2459 0.0564

SER 2459 THR 2460 0.0613

THR 2460 LYS 2461 0.0935

LYS 2461 PRO 2462 0.0536

PRO 2462 GLY 2463 0.0554

GLY 2463 ARG 2464 0.0380

ARG 2464 HIS 2465 0.0480

HIS 2465 TRP 2466 0.0398

TRP 2466 THR 2467 0.0463

THR 2467 GLU 2468 0.0567

GLU 2468 SER 2469 0.0536

SER 2469 SER 2470 0.0005

SER 2470 TRP 2471 0.0566

TRP 2471 LEU 2472 0.0429

LEU 2472 GLN 2473 0.0228

GLN 2473 ASP 2474 0.0390

ASP 2474 ALA 2475 0.0532

ALA 2475 ARG 2476 0.0453

ARG 2476 PHE 2477 -0.0432

PHE 2477 ALA 2478 0.0229

ALA 2478 THR 2479 0.0196

THR 2479 LEU 2480 0.0064

LEU 2480 ARG 2481 0.0248

ARG 2481 GLU 2482 0.0252

GLU 2482 ARG 2483 0.0091

ARG 2483 ALA 2484 0.0197

ALA 2484 ARG 2485 0.0228

ARG 2485 ASP 2486 0.0227

ASP 2486 VAL 2487 0.0049

VAL 2487 LYS 2488 0.0248

LYS 2488 GLU 2489 0.0231

GLU 2489 LEU 2490 0.0155

LEU 2490 SER 2491 0.0134

SER 2491 ASN 2492 0.0231

ASN 2492 SER 2493 -0.0880

SER 2493 GLN 2494 0.0356

GLN 2494 ASN 989 0.0467

ASN 989 LYS 990 0.0215

LYS 990 ALA 991 0.0077

ALA 991 HIS 992 0.0171

HIS 992 ARG 993 0.0085

ARG 993 GLN 994 0.0138

GLN 994 ARG 995 0.0140

ARG 995 VAL 996 0.0201

VAL 996 HIS 997 0.0180

HIS 997 PRO 998 0.0172

PRO 998 PRO 999 0.0165

PRO 999 HIS 1000 0.0108

HIS 1000 ASP 1001 0.0208

ASP 1001 LEU 1002 0.0008

LEU 1002 LEU 1003 0.0218

LEU 1003 GLY 1004 0.0064

GLY 1004 SER 1005 -0.0740

SER 1005 LEU 1006 0.0126

LEU 1006 ILE 1007 0.0179

ILE 1007 VAL 1008 0.0139

VAL 1008 GLY 1009 0.0148

GLY 1009 ARG 1010 0.0016

ARG 1010 ASP 1011 0.0097

ASP 1011 LEU 1012 0.0179

LEU 1012 ARG 1013 0.0004

ARG 1013 GLU 1014 0.0179

GLU 1014 PRO 1015 0.0058

PRO 1015 THR 1016 0.0160

THR 1016 TRP 1017 0.0102

TRP 1017 ARG 1018 0.0125

ARG 1018 HIS 1019 0.0164

HIS 1019 PHE 1020 0.0124

PHE 1020 ILE 1021 0.1111

ILE 1021 ARG 1022 0.0086

ARG 1022 VAL 1023 0.0066

VAL 1023 GLN 1024 0.0027

GLN 1024 ASP 1025 0.0073

ASP 1025 ILE 1026 0.0029

ILE 1026 PRO 1027 0.0064

PRO 1027 TRP 1028 0.0048

TRP 1028 ILE 1029 0.0073

ILE 1029 ARG 1030 0.0076

ARG 1030 ASP 1031 0.0054

ASP 1031 HIS 1032 0.0070

HIS 1032 VAL 1033 0.0051

VAL 1033 VAL 1034 0.0036

VAL 1034 GLN 1035 0.0055

GLN 1035 SER 1036 0.0051

SER 1036 ALA 1037 0.0707

ALA 1037 LEU 1038 0.0042

LEU 1038 VAL 1039 0.0074

VAL 1039 TYR 1040 0.0064

TYR 1040 PRO 1041 0.0055

PRO 1041 GLY 1042 0.0061

GLY 1042 ALA 1043 0.0078

ALA 1043 GLY 1044 0.0012

GLY 1044 PHE 1045 0.0085

PHE 1045 ILE 1046 0.0079

ILE 1046 CYS 1047 0.0029

CYS 1047 MET 1048 0.0063

MET 1048 ALA 1049 0.0073

ALA 1049 MET 1050 0.0083

MET 1050 GLU 1051 0.0008

GLU 1051 ALA 1052 0.0086

ALA 1052 MET 1053 0.0908

MET 1053 VAL 1054 0.0057

VAL 1054 GLN 1055 0.0028

GLN 1055 LEU 1056 0.0069

LEU 1056 HIS 1057 0.0082

HIS 1057 GLU 1058 0.0011

GLU 1058 LEU 1059 0.0077

LEU 1059 ARG 1060 0.0053

ARG 1060 ASP 1061 0.0083

ASP 1061 SER 1062 0.0042

SER 1062 GLN 1063 0.0040

GLN 1063 SER 1064 0.0083

SER 1064 ARG 1065 0.0001

ARG 1065 LYS 1066 0.0080

LYS 1066 VAL 1067 0.0069

VAL 1067 ALA 1068 0.0016

ALA 1068 GLY 1069 0.0765

GLY 1069 TYR 1070 0.0074

TYR 1070 ARG 1071 0.0017

ARG 1071 LEU 1072 0.0070

LEU 1072 ALA 1073 0.0023

ALA 1073 GLU 1074 0.0058

GLU 1074 VAL 1075 0.0059

VAL 1075 ASP 1076 0.0071

ASP 1076 ILE 1077 0.0073

ILE 1077 LEU 1078 0.0079

LEU 1078 ARG 1079 0.0067

ARG 1079 ALA 1080 0.0065

ALA 1080 MET 1081 0.0002

MET 1081 LEU 1082 0.0074

LEU 1082 ILE 1083 0.0017

ILE 1083 PRO 1084 0.0065

PRO 1084 ASP 1085 -0.0331

ASP 1085 THR 1086 0.0076

THR 1086 SER 1087 0.0072

SER 1087 GLU 1088 0.0108

GLU 1088 GLY 1089 0.0038

GLY 1089 LEU 1090 0.0041

LEU 1090 GLU 1091 0.0145

GLU 1091 ALA 1092 0.0052

ALA 1092 HIS 1093 0.0124

HIS 1093 ILE 1094 0.0083

ILE 1094 SER 1095 0.0124

SER 1095 LEU 1096 0.0101

LEU 1096 ARG 1097 0.0087

ARG 1097 PRO 1098 0.0100

PRO 1098 CYS 1099 0.0013

CYS 1099 SER 1100 0.0114

SER 1100 THR 1101 -0.1316

THR 1101 LYS 1102 0.0020

LYS 1102 LEU 1103 0.0088

LEU 1103 LEU 1104 0.0069

LEU 1104 LEU 1105 0.0036

LEU 1105 THR 1106 0.0081

THR 1106 ASN 1107 0.0011

ASN 1107 GLU 1108 0.0044

GLU 1108 TRP 1109 0.0086

TRP 1109 TYR 1110 0.0061

TYR 1110 ASP 1111 0.0082

ASP 1111 PHE 1112 0.0042

PHE 1112 CYS 1113 0.0087

CYS 1113 VAL 1114 0.0049

VAL 1114 SER 1115 0.0081

SER 1115 SER 1116 0.0043

SER 1116 VAL 1117 -0.0245

VAL 1117 GLY 1118 0.0109

GLY 1118 ASP 1119 0.0054

ASP 1119 ASP 1120 0.0079

ASP 1120 ASP 1121 0.0108

ASP 1121 LYS 1122 0.0004

LYS 1122 PHE 1123 0.0093

PHE 1123 VAL 1124 0.0072

VAL 1124 ASP 1125 0.0070

ASP 1125 HIS 1126 0.0110

HIS 1126 CYS 1127 0.0085

CYS 1127 ARG 1128 0.0076

ARG 1128 GLY 1129 0.0084

GLY 1129 ARG 1130 0.0109

ARG 1130 ILE 1131 0.0072

ILE 1131 THR 1132 0.0108

THR 1132 ILE 1133 0.0474

ILE 1133 GLU 1134 0.0041

GLU 1134 PHE 1135 0.0001

PHE 1135 ASP 1136 0.0033

ASP 1136 THR 1137 0.0045

THR 1137 SER 1138 0.0018

SER 1138 GLY 1139 0.0032

GLY 1139 SER 1140 0.0006

SER 1140 ALA 1141 0.0043

ALA 1141 ASP 1142 0.0028

ASP 1142 THR 1143 0.0004

THR 1143 PRO 1144 0.0042

PRO 1144 ARG 1145 0.0031

ARG 1145 THR 1146 0.0025

THR 1146 SER 1147 0.0041

SER 1147 LEU 1148 0.0022

LEU 1148 ARG 1149 -0.2219

ARG 1149 GLU 1150 0.0088

GLU 1150 ARG 1151 0.0064

ARG 1151 SER 1152 0.0046

SER 1152 ARG 1153 0.0075

ARG 1153 SER 1154 0.0034

SER 1154 THR 1155 0.0014

THR 1155 GLY 1156 0.0061

GLY 1156 LEU 1157 0.0073

LEU 1157 MET 1158 0.0064

MET 1158 ARG 1159 0.0064

ARG 1159 SER 1160 0.0071

SER 1160 VAL 1161 0.0086

VAL 1161 ASP 1162 0.0084

ASP 1162 PRO 1163 0.0043

PRO 1163 SER 1164 0.0066

SER 1164 ASN 1165 0.0987

ASN 1165 LEU 1166 0.0024

LEU 1166 TYR 1167 0.0044

TYR 1167 SER 1168 0.0014

SER 1168 PHE 1169 0.0055

PHE 1169 LEU 1170 0.0007

LEU 1170 ARG 1171 0.0057

ARG 1171 ALA 1172 0.0017

ALA 1172 GLN 1173 0.0042

GLN 1173 GLY 1174 0.0032

GLY 1174 ILE 1175 0.0030

ILE 1175 TYR 1176 0.0055

TYR 1176 HIS 1177 0.0039

HIS 1177 GLY 1178 0.0057

GLY 1178 PRO 1179 0.0056

PRO 1179 ILE 1180 0.0003

ILE 1180 PHE 1181 0.0178

PHE 1181 GLN 1182 0.0025

GLN 1182 ASN 1183 0.0057

ASN 1183 LEU 1184 0.0033

LEU 1184 LYS 1185 0.0062

LYS 1185 THR 1186 0.0045

THR 1186 ILE 1187 0.0057

ILE 1187 SER 1188 0.0057

SER 1188 SER 1189 0.0063

SER 1189 ARG 1190 0.0052

ARG 1190 LYS 1191 0.0067

LYS 1191 ASP 1192 0.0014

ASP 1192 HIS 1193 0.0044

HIS 1193 SER 1194 0.0064

SER 1194 GLU 1195 0.0049

GLU 1195 SER 1196 0.0065

SER 1196 SER 1197 -0.0620

SER 1197 PHE 1198 0.0032

PHE 1198 VAL 1199 0.0024

VAL 1199 VAL 1200 0.0010

VAL 1200 ALA 1201 0.0080

ALA 1201 ASN 1202 0.0035

ASN 1202 THR 1203 0.0070

THR 1203 ALA 1204 0.0016

ALA 1204 SER 1205 0.0070

SER 1205 VAL 1206 0.0084

VAL 1206 MET 1207 0.0017

MET 1207 PRO 1208 0.0034

PRO 1208 ASN 1209 0.0068

ASN 1209 GLY 1210 0.0048

GLY 1210 PHE 1211 0.0057

PHE 1211 GLN 1212 0.0070

GLN 1212 SER 1213 0.0317

SER 1213 PRO 1214 0.0076

PRO 1214 HIS 1215 0.0023

HIS 1215 VAL 1216 0.0049

VAL 1216 ILE 1217 0.0031

ILE 1217 HIS 1218 0.0079

HIS 1218 PRO 1219 0.0051

PRO 1219 THR 1220 0.0063

THR 1220 THR 1221 0.0076

THR 1221 LEU 1222 0.0074

LEU 1222 ASP 1223 0.0059

ASP 1223 SER 1224 0.0066

SER 1224 ILE 1225 0.0073

ILE 1225 PHE 1226 0.0070

PHE 1226 GLN 1227 0.0066

GLN 1227 GLY 1228 0.0069

GLY 1228 ALA 1229 -0.0327

ALA 1229 TYR 1230 0.0012

TYR 1230 THR 1231 0.0059

THR 1231 ALA 1232 0.0063

ALA 1232 LEU 1233 0.0036

LEU 1233 PRO 1234 0.0003

PRO 1234 GLY 1235 0.0053

GLY 1235 ALA 1236 0.0006

ALA 1236 GLY 1237 0.0063

GLY 1237 LEU 1238 0.0024

LEU 1238 ASP 1239 0.0049

ASP 1239 GLN 1240 0.0037

GLN 1240 ASN 1241 0.0058

ASN 1241 THR 1242 0.0014

THR 1242 ALA 1243 0.0019

ALA 1243 MET 1244 0.0030

MET 1244 ILE 1245 0.0705

ILE 1245 PRO 1246 0.0051

PRO 1246 ARG 1247 0.0067

ARG 1247 SER 1248 0.0064

SER 1248 ILE 1249 0.0062

ILE 1249 GLN 1250 0.0068

GLN 1250 GLU 1251 0.0037

GLU 1251 LEU 1252 0.0046

LEU 1252 TYR 1253 0.0043

TYR 1253 LEU 1254 0.0040

LEU 1254 SER 1255 0.0051

SER 1255 SER 1256 0.0005

SER 1256 ALA 1257 0.0063

ALA 1257 LEU 1258 0.0058

LEU 1258 THR 1259 0.0048

THR 1259 SER 1260 0.0069

SER 1260 ASP 1261 0.0118

ASP 1261 VAL 1262 0.0042

VAL 1262 GLY 1263 0.0011

GLY 1263 GLN 1264 0.0062

GLN 1264 CYS 1265 0.0012

CYS 1265 LEU 1266 0.0064

LEU 1266 VAL 1267 0.0023

VAL 1267 SER 1268 0.0059

SER 1268 ASP 1269 0.0041

ASP 1269 THR 1270 0.0058

THR 1270 SER 1271 0.0046

SER 1271 LEU 1272 0.0054

LEU 1272 ILE 1273 0.0059

ILE 1273 ARG 1274 0.0050

ARG 1274 TYR 1275 0.0049

TYR 1275 ASP 1276 0.0052

ASP 1276 GLY 1277 0.0661

GLY 1277 GLN 1278 0.0027

GLN 1278 SER 1279 0.0034

SER 1279 PHE 1280 0.0061

PHE 1280 THR 1281 0.0034

THR 1281 VAL 1282 0.0057

VAL 1282 ASN 1283 0.0036

ASN 1283 VAL 1284 0.0048

VAL 1284 ASP 1285 0.0047

ASP 1285 VAL 1286 0.0048

VAL 1286 SER 1287 0.0054

SER 1287 SER 1288 0.0053

SER 1288 LYS 1289 0.0036

LYS 1289 ALA 1290 0.0033

ALA 1290 ASP 1291 0.0061

ASP 1291 SER 1292 0.0044

SER 1292 GLU 1293 0.0015

GLU 1293 HIS 1294 0.0058

HIS 1294 THR 1295 0.0033

THR 1295 PRO 1296 0.0063

PRO 1296 VAL 1297 0.0029

VAL 1297 LEU 1298 0.0054

LEU 1298 GLU 1299 0.0042

GLU 1299 ILE 1300 0.0051

ILE 1300 LYS 1301 0.0051

LYS 1301 GLY 1302 0.0040

GLY 1302 LEU 1303 0.0064

LEU 1303 ARG 1304 0.0041

ARG 1304 ASN 1305 0.0059

ASN 1305 GLN 1306 0.0054

GLN 1306 SER 1307 0.0044

SER 1307 VAL 1308 0.0053

VAL 1308 GLY 1309 0.2658

GLY 1309 GLN 1310 0.0037

GLN 1310 MET 1311 0.0127

MET 1311 ALA 1312 0.0199

ALA 1312 PRO 1313 0.0094

PRO 1313 GLN 1314 0.0173

GLN 1314 PRO 1315 0.0165

PRO 1315 GLY 1316 0.0168

GLY 1316 ASP 1317 0.0173

ASP 1317 SER 1318 0.0276

SER 1318 SER 1319 0.0291

SER 1319 ASN 1320 0.0063

ASN 1320 ASN 1321 0.0247

ASN 1321 ASP 1322 0.0033

ASP 1322 LEU 1323 0.0292

LEU 1323 CYS 1324 0.0224

CYS 1324 PHE 1325 0.1723

PHE 1325 LYS 1326 0.0015

LYS 1326 LEU 1327 0.0018

LEU 1327 ASP 1328 0.0058

ASP 1328 TRP 1329 0.0013

TRP 1329 ALA 1330 0.0059

ALA 1330 PRO 1331 0.0031

PRO 1331 ASP 1332 0.0059

ASP 1332 ILE 1333 0.0054

ILE 1333 SER 1334 0.0041

SER 1334 SER 1335 0.0018

SER 1335 VAL 1336 0.0056

VAL 1336 LYS 1337 0.0035

LYS 1337 GLN 1338 0.0052

GLN 1338 GLU 1339 0.0043

GLU 1339 ARG 1340 0.0046

ARG 1340 LEU 1341 0.4665

LEU 1341 LYS 1342 0.0410

LYS 1342 GLU 1343 0.0438

GLU 1343 LYS 1344 0.0088

LYS 1344 PHE 1345 0.0383

PHE 1345 GLY 1346 0.0334

GLY 1346 PHE 1347 0.0344

PHE 1347 PRO 1348 0.0383

PRO 1348 LEU 1349 0.0440

LEU 1349 ASP 1350 0.0134

ASP 1350 PRO 1351 0.0423

PRO 1351 THR 1352 0.0081

THR 1352 GLU 1353 0.0433

GLU 1353 ALA 1354 0.0091

ALA 1354 ASP 1355 0.0354

ASP 1355 ILE 1356 0.0247

ILE 1356 ILE 1357 -0.2073

ILE 1357 MET 1358 0.0949

MET 1358 GLY 1359 0.0237

GLY 1359 LEU 1360 0.0811

LEU 1360 ARG 1361 0.0398

ARG 1361 GLN 1362 0.0585

GLN 1362 ALA 1363 0.0657

ALA 1363 CYS 1364 0.0350

CYS 1364 ILE 1365 0.0870

ILE 1365 HIS 1366 0.0175

HIS 1366 PHE 1367 0.0947

PHE 1367 ILE 1368 0.0127

ILE 1368 HIS 1369 0.0920

HIS 1369 ARG 1370 0.0313

ARG 1370 SER 1371 0.0769

SER 1371 LEU 1372 0.0373

LEU 1372 GLN 1373 0.1182

GLN 1373 SER 1374 0.0771

SER 1374 LEU 1375 0.0395

LEU 1375 THR 1376 0.0997

THR 1376 ALA 1377 0.0212

ALA 1377 PRO 1378 0.0966

PRO 1378 ASP 1379 0.0929

ASP 1379 ARG 1380 0.0213

ARG 1380 ASP 1381 0.0779

ASP 1381 GLN 1382 0.0764

GLN 1382 LEU 1383 0.0987

LEU 1383 ASP 1384 0.0811

ASP 1384 TRP 1385 0.0208

TRP 1385 HIS 1386 0.0876

HIS 1386 GLN 1387 0.0485

GLN 1387 LYS 1388 0.0533

LYS 1388 ARG 1389 0.1226

ARG 1389 PHE 1390 0.0194

PHE 1390 TYR 1391 0.1021

TYR 1391 ASP 1392 0.0261

ASP 1392 TRP 1393 0.0939

TRP 1393 MET 1394 0.0273

MET 1394 VAL 1395 0.0790

VAL 1395 LEU 1396 0.0702

LEU 1396 GLN 1397 0.0394

GLN 1397 ILE 1398 0.0887

ILE 1398 GLN 1399 0.0253

GLN 1399 LEU 1400 0.1024

LEU 1400 ALA 1401 0.0129

ALA 1401 GLU 1402 0.0970

GLU 1402 GLU 1403 0.0413

GLU 1403 ASP 1404 0.0699

ASP 1404 ARG 1405 0.1176

ARG 1405 LEU 1406 0.0525

LEU 1406 ALA 1407 0.0900

ALA 1407 PRO 1408 0.1059

PRO 1408 ASN 1409 0.0801

ASN 1409 SER 1410 0.1059

SER 1410 SER 1411 0.1057

SER 1411 ALA 1412 0.0146

ALA 1412 TRP 1413 0.0971

TRP 1413 LEU 1414 0.1039

LEU 1414 GLN 1415 0.0630

GLN 1415 CYS 1416 0.0422

CYS 1416 SER 1417 0.0165

SER 1417 SER 1418 0.0847

SER 1418 SER 1419 0.0599

SER 1419 ASP 1420 0.0570

ASP 1420 GLU 1421 0.0828

GLU 1421 GLN 1422 0.0342

GLN 1422 LYS 1423 0.0999

LYS 1423 LEU 1424 0.0078

LEU 1424 LEU 1425 0.1005

LEU 1425 GLU 1426 0.0324

GLU 1426 ASN 1427 0.0840

ASN 1427 VAL 1428 0.0319

VAL 1428 ARG 1429 0.0748

ARG 1429 ALA 1430 0.0758

ALA 1430 SER 1431 0.0419

SER 1431 SER 1432 0.0733

SER 1432 VAL 1433 0.0994

VAL 1433 ASN 1434 0.0429

ASN 1434 GLY 1435 0.0616

GLY 1435 GLN 1436 0.0663

GLN 1436 MET 1437 0.0225

MET 1437 VAL 1438 0.0827

VAL 1438 VAL 1439 0.0195

VAL 1439 HIS 1440 0.0907

HIS 1440 VAL 1441 0.0255

VAL 1441 GLY 1442 0.0942

GLY 1442 LYS 1443 0.0223

LYS 1443 SER 1444 0.0896

SER 1444 MET 1445 0.0096

MET 1445 LEU 1446 0.0943

LEU 1446 ALA 1447 0.0735

ALA 1447 ILE 1448 0.0458

ILE 1448 LEU 1449 0.0519

LEU 1449 ARG 1450 0.0697

ARG 1450 HIS 1451 0.0950

HIS 1451 GLU 1452 0.0011

GLU 1452 ILE 1453 0.0201

ILE 1453 ALA 1454 0.0534

ALA 1454 PRO 1455 0.0794

PRO 1455 LEU 1456 0.0900

LEU 1456 GLU 1457 0.0103

GLU 1457 LEU 1458 0.0832

LEU 1458 MET 1459 0.0688

MET 1459 LEU 1460 0.0781

LEU 1460 GLN 1461 0.0123

GLN 1461 ASP 1462 0.0711

ASP 1462 LYS 1463 0.0307

LYS 1463 LEU 1464 0.0790

LEU 1464 LEU 1465 0.0128

LEU 1465 TYR 1466 0.0896

TYR 1466 ARG 1467 0.0808

ARG 1467 TYR 1468 0.0399

TYR 1468 TYR 1469 -0.0037

TYR 1469 THR 1470 0.0284

THR 1470 ASP 1471 0.0281

ASP 1471 ALA 1472 0.0253

ALA 1472 ILE 1473 0.0262

ILE 1473 LYS 1474 0.0060

LYS 1474 TRP 1475 0.0340

TRP 1475 ASP 1476 0.0314

ASP 1476 ARG 1477 0.0125

ARG 1477 SER 1478 0.0207

SER 1478 TYR 1479 0.0266

TYR 1479 GLN 1480 0.0343

GLN 1480 GLN 1481 0.0012

GLN 1481 ILE 1482 0.0343

ILE 1482 ASP 1483 0.0240

ASP 1483 GLN 1484 0.0201

GLN 1484 LEU 1485 0.0749

LEU 1485 VAL 1486 0.0053

VAL 1486 LYS 1487 0.0068

LYS 1487 LEU 1488 0.0001

LEU 1488 HIS 1489 0.0067

HIS 1489 ALA 1490 0.0038

ALA 1490 HIS 1491 0.0060

HIS 1491 LYS 1492 0.0013

LYS 1492 CYS 1493 0.0062

CYS 1493 PRO 1494 0.0015

PRO 1494 THR 1495 0.0066

THR 1495 ALA 1496 0.0067

ALA 1496 LYS 1497 0.0060

LYS 1497 ILE 1498 0.0056

ILE 1498 ILE 1499 0.0061

ILE 1499 GLU 1500 0.0045

GLU 1500 ILE 1501 -0.0362

ILE 1501 GLY 1502 0.0077

GLY 1502 ALA 1503 0.0094

ALA 1503 GLY 1504 0.0094

GLY 1504 THR 1505 0.0043

THR 1505 GLY 1506 0.0154

GLY 1506 GLY 1507 0.0177

GLY 1507 CYS 1508 0.0044

CYS 1508 THR 1509 0.0172

THR 1509 ARG 1510 0.0082

ARG 1510 ALA 1511 0.0121

ALA 1511 VAL 1512 0.0087

VAL 1512 LEU 1513 0.0112

LEU 1513 ASP 1514 0.0145

ASP 1514 ALA 1515 0.0028

ALA 1515 LEU 1516 0.0168

LEU 1516 SER 1517 0.0152

SER 1517 ASN 1518 0.0111

ASN 1518 GLN 1519 0.0006

GLN 1519 GLY 1520 0.0110

GLY 1520 ILE 1521 0.0033

ILE 1521 ALA 1522 0.0066

ALA 1522 ARG 1523 0.0010

ARG 1523 CYS 1524 0.0093

CYS 1524 ALA 1525 0.0110

ALA 1525 GLN 1526 0.0100

GLN 1526 TYR 1527 0.0101

TYR 1527 ASP 1528 0.0111

ASP 1528 PHE 1529 0.0063

PHE 1529 THR 1530 0.0099

THR 1530 ASP 1531 0.0106

ASP 1531 VAL 1532 0.0109

VAL 1532 SER 1533 0.0139

SER 1533 SER 1534 0.0120

SER 1534 GLY 1535 0.0104

GLY 1535 PHE 1536 0.0208

PHE 1536 PHE 1537 0.0205

PHE 1537 GLU 1538 0.0008

GLU 1538 ALA 1539 0.0202

ALA 1539 ALA 1540 0.0077

ALA 1540 GLN 1541 0.0193

GLN 1541 GLN 1542 0.0048

GLN 1542 LYS 1543 0.0166

LYS 1543 PHE 1544 0.0120

PHE 1544 ALA 1545 0.0150

ALA 1545 ALA 1546 0.0198

ALA 1546 PHE 1547 0.0026

PHE 1547 ASP 1548 0.0201

ASP 1548 ASP 1549 -0.1776

ASP 1549 VAL 1550 0.0073

VAL 1550 ILE 1551 0.0241

ILE 1551 ARG 1552 0.0257

ARG 1552 PHE 1553 0.0228

PHE 1553 GLN 1554 0.0204

GLN 1554 LYS 1555 0.0250

LYS 1555 LEU 1556 0.0033

LEU 1556 ASP 1557 0.0221

ASP 1557 ILE 1558 0.0038

ILE 1558 GLU 1559 0.0227

GLU 1559 LYS 1560 0.0247

LYS 1560 ASP 1561 0.0188

ASP 1561 ILE 1562 0.0241

ILE 1562 GLU 1563 0.0257

GLU 1563 MET 1564 0.0160

MET 1564 GLN 1565 0.0019

GLN 1565 GLY 1566 0.0247

GLY 1566 PHE 1567 0.0217

PHE 1567 GLU 1568 0.0120

GLU 1568 CYS 1569 0.0082

CYS 1569 GLY 1570 0.0229

GLY 1570 SER 1571 0.0071

SER 1571 TYR 1572 0.0200

TYR 1572 ASP 1573 0.0241

ASP 1573 LEU 1574 0.0188

LEU 1574 VAL 1575 0.0243

VAL 1575 ILE 1576 0.0130

ILE 1576 ALA 1577 0.0247

ALA 1577 SER 1578 0.0148

SER 1578 GLN 1579 0.0248

GLN 1579 VAL 1580 0.0230

VAL 1580 LEU 1581 0.0415

LEU 1581 HIS 1582 0.0325

HIS 1582 ALA 1583 0.0279

ALA 1583 THR 1584 0.0107

THR 1584 GLY 1585 0.0150

GLY 1585 LYS 1586 0.0131

LYS 1586 MET 1587 0.0324

MET 1587 GLU 1588 0.0106

GLU 1588 HIS 1589 0.0298

HIS 1589 THR 1590 0.0043

THR 1590 MET 1591 0.0291

MET 1591 ALA 1592 0.0190

ALA 1592 ASN 1593 0.0124

ASN 1593 VAL 1594 0.0241

VAL 1594 ARG 1595 0.0138

ARG 1595 LYS 1596 0.0326

LYS 1596 LEU 1597 0.0628

LEU 1597 LEU 1598 0.0312

LEU 1598 LYS 1599 0.0250

LYS 1599 PRO 1600 0.0116

PRO 1600 GLY 1601 0.0301

GLY 1601 GLY 1602 0.0059

GLY 1602 LYS 1603 0.0248

LYS 1603 LEU 1604 0.0308

LEU 1604 LEU 1605 0.0127

LEU 1605 LEU 1606 0.0338

LEU 1606 VAL 1607 0.0155

VAL 1607 GLU 1608 0.0328

GLU 1608 THR 1609 0.0339

THR 1609 THR 1610 0.0112

THR 1610 ARG 1611 0.0302

ARG 1611 ASP 1612 0.0201

ASP 1612 GLU 1613 -0.0154

GLU 1613 MET 1614 0.0684

MET 1614 ASP 1615 0.0285

ASP 1615 LEU 1616 0.0592

LEU 1616 GLN 1617 0.0534

GLN 1617 LEU 1618 0.0351

LEU 1618 VAL 1619 0.0630

VAL 1619 PHE 1620 0.0362

PHE 1620 GLY 1621 0.0563

GLY 1621 LEU 1622 0.0553

LEU 1622 LEU 1623 0.0728

LEU 1623 PRO 1624 0.0233

PRO 1624 GLY 1625 0.0759

GLY 1625 TRP 1626 0.0813

TRP 1626 TRP 1627 0.0386

TRP 1627 LEU 1628 0.0560

LEU 1628 SER 1629 0.1766

SER 1629 SER 1630 0.0129

SER 1630 GLU 1631 0.0521

GLU 1631 GLU 1632 0.0585

GLU 1632 GLU 1633 0.0521

GLU 1633 ARG 1634 0.0169

ARG 1634 GLN 1635 0.0610

GLN 1635 MET 1636 0.0399

MET 1636 SER 1637 0.0494

SER 1637 PRO 1638 0.0613

PRO 1638 SER 1639 0.0614

SER 1639 LEU 1640 0.0252

LEU 1640 SER 1641 0.0600

SER 1641 THR 1642 0.0614

THR 1642 ASN 1643 0.0033

ASN 1643 SER 1644 0.0614

SER 1644 TRP 1645 0.1569

TRP 1645 GLU 1646 0.0167

GLU 1646 LYS 1647 0.0146

LYS 1647 VAL 1648 0.0259

VAL 1648 LEU 1649 0.0296

LEU 1649 LYS 1650 0.0033

LYS 1650 LYS 1651 0.0266

LYS 1651 THR 1652 0.0207

THR 1652 GLY 1653 0.0286

GLY 1653 PHE 1654 0.0194

PHE 1654 ASP 1655 0.0273

ASP 1655 GLY 1656 0.0216

GLY 1656 LEU 1657 0.0064

LEU 1657 ASP 1658 0.0290

ASP 1658 ILE 1659 0.0067

ILE 1659 GLU 1660 0.0242

GLU 1660 LEU 1661 -0.0420

LEU 1661 ARG 1662 0.0405

ARG 1662 ASP 1663 0.0015

ASP 1663 CYS 1664 0.0478

CYS 1664 ASP 1665 0.0245

ASP 1665 SER 1666 0.0484

SER 1666 ASP 1667 0.0223

ASP 1667 GLU 1668 0.0288

GLU 1668 PHE 1669 0.0180

PHE 1669 TYR 1670 0.0440

TYR 1670 SER 1671 0.0482

SER 1671 PHE 1672 0.0486

PHE 1672 SER 1673 0.0250

SER 1673 VAL 1674 0.0478

VAL 1674 MET 1675 0.0082

MET 1675 MET 1676 0.0421

MET 1676 ALA 1677 -0.0954

ALA 1677 THR 1678 0.0252

THR 1678 ALA 1679 0.0299

ALA 1679 SER 1680 0.0021

SER 1680 SER 1681 0.0264

SER 1681 THR 1682 0.0097

THR 1682 ILE 1683 0.0214

ILE 1683 ALA 1684 0.0255

ALA 1684 SER 1685 0.0021

SER 1685 SER 1686 0.0295

SER 1686 SER 1687 0.0057

SER 1687 MET 1688 0.0285

MET 1688 ALA 1689 0.0148

ALA 1689 PHE 1690 0.0291

PHE 1690 ALA 1691 0.0269

ALA 1691 ILE 1692 0.0299

ILE 1692 VAL 1693 0.1375

VAL 1693 TYR 1694 0.0628

TYR 1694 GLY 1695 0.0489

GLY 1695 GLU 1696 0.0580

GLU 1696 VAL 1697 0.0593

VAL 1697 PRO 1698 0.0291

PRO 1698 LEU 1699 0.0627

LEU 1699 PRO 1700 0.0439

PRO 1700 ASP 1701 0.0175

ASP 1701 GLN 1702 0.0630

GLN 1702 PHE 1703 0.0115

PHE 1703 LEU 1704 0.0563

LEU 1704 ASP 1705 0.0287

ASP 1705 ASP 1706 0.0414

ASP 1706 MET 1707 0.0404

MET 1707 LYS 1708 0.0301

LYS 1708 THR 1709 0.0162

THR 1709 ALA 1710 0.0048

ALA 1710 ILE 1711 0.0574

ILE 1711 SER 1712 0.0143

SER 1712 SER 1713 0.0541

SER 1713 SER 1714 0.0186

SER 1714 ALA 1715 0.0501

ALA 1715 VAL 1716 0.0219

VAL 1716 SER 1717 0.0528

SER 1717 ASP 1718 0.0542

ASP 1718 PRO 1719 0.0351

PRO 1719 VAL 1720 0.0532

VAL 1720 VAL 1721 0.0547

VAL 1721 GLY 1722 0.0565

GLY 1722 HIS 1723 0.0439

HIS 1723 LEU 1724 0.0212

LEU 1724 ASP 1725 0.0463

ASP 1725 SER 1726 0.0138

SER 1726 ILE 1727 0.0642

ILE 1727 ASP 1728 0.0654

ASP 1728 ALA 1729 0.0281

ALA 1729 THR 1730 0.0644

THR 1730 GLY 1731 0.0655

GLY 1731 LYS 1732 0.0655

LYS 1732 PHE 1733 0.0347

PHE 1733 CYS 1734 0.0640

CYS 1734 ILE 1735 0.0611

ILE 1735 PHE 1736 0.0579

PHE 1736 ILE 1737 0.0653

ILE 1737 GLU 1738 0.0505

GLU 1738 ASP 1739 0.0647

ASP 1739 PRO 1740 0.0191

PRO 1740 GLU 1741 0.1775

GLU 1741 THR 1742 0.0797

THR 1742 ASP 1743 0.0296

ASP 1743 ILE 1744 0.0656

ILE 1744 LEU 1745 0.0246

LEU 1745 SER 1746 0.0533

SER 1746 SER 1747 0.0650

SER 1747 PRO 1748 0.0373

PRO 1748 ASP 1749 0.0496

ASP 1749 GLU 1750 0.0752

GLU 1750 LYS 1751 0.0187

LYS 1751 SER 1752 0.0728

SER 1752 TYR 1753 0.0339

TYR 1753 ALA 1754 0.0524

ALA 1754 SER 1755 0.0503

SER 1755 ILE 1756 0.0347

ILE 1756 GLN 1757 0.0120

GLN 1757 LYS 1758 0.0081

LYS 1758 LEU 1759 0.0687

LEU 1759 VAL 1760 0.0231

VAL 1760 THR 1761 0.0664

THR 1761 ARG 1762 0.0065

ARG 1762 CYS 1763 0.0687

CYS 1763 LYS 1764 0.0688

LYS 1764 GLY 1765 0.0450

GLY 1765 LEU 1766 0.0660

LEU 1766 ILE 1767 0.0655

ILE 1767 TRP 1768 0.0591

TRP 1768 VAL 1769 0.0689

VAL 1769 SER 1770 0.0403

SER 1770 ARG 1771 0.0599

ARG 1771 GLY 1772 0.0064

GLY 1772 GLY 1773 -0.0037

GLY 1773 ALA 1774 0.0663

ALA 1774 MET 1775 0.0609

MET 1775 HIS 1776 0.0691

HIS 1776 GLY 1777 0.0743

GLY 1777 THR 1778 0.0594

THR 1778 ARG 1779 0.0652

ARG 1779 PRO 1780 0.0405

PRO 1780 ASN 1781 0.0486

ASN 1781 SER 1782 0.0470

SER 1782 SER 1783 0.0364

SER 1783 LEU 1784 0.0747

LEU 1784 LYS 1785 0.0312

LYS 1785 THR 1786 0.0569

THR 1786 GLY 1787 0.0342

GLY 1787 LEU 1788 0.0427

LEU 1788 LEU 1789 0.0687

LEU 1789 ARG 1790 0.0166

ARG 1790 THR 1791 0.0710

THR 1791 LEU 1792 0.0068

LEU 1792 ARG 1793 0.0705

ARG 1793 LEU 1794 0.0378

LEU 1794 GLU 1795 0.0514

GLU 1795 TYR 1796 0.0225

TYR 1796 THR 1797 0.0667

THR 1797 GLU 1798 0.0088

GLU 1798 LYS 1799 0.0633

LYS 1799 ARG 1800 0.0713

ARG 1800 PHE 1801 0.0627

PHE 1801 ILE 1802 0.0716

ILE 1802 SER 1803 0.0641

SER 1803 LEU 1804 0.0602

LEU 1804 ASP 1805 -0.0436

ASP 1805 LEU 1806 0.0465

LEU 1806 ASP 1807 0.0515

ASP 1807 SER 1808 0.0596

SER 1808 ALA 1809 0.0623

ALA 1809 ARG 1810 0.0060

ARG 1810 PRO 1811 0.0207

PRO 1811 GLN 1812 0.0583

GLN 1812 TRP 1813 0.0130

TRP 1813 ASN 1814 0.0622

ASN 1814 HIS 1815 0.0526

HIS 1815 ASP 1816 0.0109

ASP 1816 SER 1817 0.0601

SER 1817 ILE 1818 0.0184

ILE 1818 THR 1819 0.0579

THR 1819 THR 1820 0.0123

THR 1820 ILE 1821 -0.0033

ILE 1821 ASN 1822 0.0177

ASN 1822 GLU 1823 0.0117

GLU 1823 VAL 1824 0.0173

VAL 1824 LEU 1825 0.0114

LEU 1825 CYS 1826 0.0259

CYS 1826 GLY 1827 0.0009

GLY 1827 ALA 1828 0.0267

ALA 1828 LEU 1829 0.0109

LEU 1829 ALA 1830 0.0255

ALA 1830 GLN 1831 0.0077

GLN 1831 ASN 1832 0.0259

ASN 1832 ALA 1833 0.0153

ALA 1833 ASP 1834 0.0096

ASP 1834 SER 1835 0.0226

SER 1835 SER 1836 0.0113

SER 1836 ILE 1837 0.1308

ILE 1837 LYS 1838 0.0180

LYS 1838 ASP 1839 0.0302

ASP 1839 SER 1840 0.0299

SER 1840 GLU 1841 0.0273

GLU 1841 PHE 1842 0.0241

PHE 1842 ALA 1843 0.0301

ALA 1843 GLU 1844 0.0201

GLU 1844 GLN 1845 0.0248

GLN 1845 ASP 1846 0.0228

ASP 1846 GLY 1847 0.0135

GLY 1847 GLN 1848 0.0215

GLN 1848 LEU 1849 0.0289

LEU 1849 PHE 1850 0.0017

PHE 1850 VAL 1851 0.0243

VAL 1851 PRO 1852 0.0048

PRO 1852 ARG 1853 -0.0391

ARG 1853 ILE 1854 0.0078

ILE 1854 SER 1855 0.0083

SER 1855 CYS 1856 0.0010

CYS 1856 ASP 1857 0.0204

ASP 1857 ILE 1858 0.0112

ILE 1858 ALA 1859 0.0210

ALA 1859 ARG 1860 0.0254

ARG 1860 ASN 1861 0.0233

ASN 1861 GLU 1862 0.0121

GLU 1862 ASP 1863 0.0234

ASP 1863 LEU 1864 0.0254

LEU 1864 SER 1865 0.0190

SER 1865 SER 1866 0.0160

SER 1866 ASP 1867 0.0138

ASP 1867 SER 1868 0.0246

SER 1868 ASN 1869 -0.1548

ASN 1869 SER 1870 0.0897

SER 1870 PRO 1871 0.1067

PRO 1871 ALA 1872 0.0823

ALA 1872 GLN 1873 0.0704

GLN 1873 MET 1874 0.0952

MET 1874 GLU 1875 0.1075

GLU 1875 PRO 1876 0.0901

PRO 1876 PHE 1877 0.0183

PHE 1877 HIS 1878 0.1053

HIS 1878 GLN 1879 0.0563

GLN 1879 PRO 1880 0.1058

PRO 1880 GLY 1881 0.1064

GLY 1881 LYS 1882 0.1045

LYS 1882 LEU 1883 0.0197

LEU 1883 LEU 1884 0.1036

LEU 1884 GLN 1885 0.1089

GLN 1885 MET 1886 0.0363

MET 1886 GLY 1887 0.0442

GLY 1887 ILE 1888 0.0440

ILE 1888 LYS 1889 0.0261

LYS 1889 THR 1890 0.0255

THR 1890 PRO 1891 0.0022

PRO 1891 GLY 1892 0.0369

GLY 1892 LEU 1893 0.0211

LEU 1893 ILE 1894 0.0452

ILE 1894 ASP 1895 0.0108

ASP 1895 THR 1896 0.0383

THR 1896 LEU 1897 0.0432

LEU 1897 GLN 1898 0.0145

GLN 1898 PHE 1899 0.0409

PHE 1899 SER 1900 0.0333

SER 1900 LYS 1901 0.1759

LYS 1901 THR 1902 0.0919

THR 1902 ASP 1903 0.1003

ASP 1903 ALA 1904 0.0966

ALA 1904 THR 1905 0.1016

THR 1905 ASP 1906 0.1089

ASP 1906 ASN 1907 0.0462

ASN 1907 LEU 1908 0.0293

LEU 1908 PRO 1909 0.0527

PRO 1909 ASN 1910 0.0788

ASN 1910 ASP 1911 0.0382

ASP 1911 TYR 1912 0.0855

TYR 1912 ILE 1913 0.1051

ILE 1913 GLU 1914 0.0483

GLU 1914 ILE 1915 0.1059

ILE 1915 GLU 1916 0.0692

GLU 1916 PRO 1917 0.0335

PRO 1917 LYS 1918 0.0656

LYS 1918 ALA 1919 0.0471

ALA 1919 PHE 1920 0.0619

PHE 1920 GLY 1921 0.0286

GLY 1921 LEU 1922 0.0620

LEU 1922 ASN 1923 0.0435

ASN 1923 PHE 1924 0.0639

PHE 1924 ARG 1925 0.0609

ARG 1925 ASP 1926 0.0110

ASP 1926 VAL 1927 0.0658

VAL 1927 MET 1928 0.0588

MET 1928 VAL 1929 0.0343

VAL 1929 ALA 1930 0.0346

ALA 1930 MET 1931 0.0600

MET 1931 GLY 1932 0.0661

GLY 1932 GLN 1933 -0.0247

GLN 1933 LEU 1934 0.0666

LEU 1934 GLU 1935 0.0633

GLU 1935 GLU 1936 0.0688

GLU 1936 SER 1937 0.0226

SER 1937 ILE 1938 0.0640

ILE 1938 MET 1939 0.0707

MET 1939 GLY 1940 0.0667

GLY 1940 PHE 1941 0.0145

PHE 1941 GLU 1942 0.0687

GLU 1942 CYS 1943 0.0574

CYS 1943 ALA 1944 0.0699

ALA 1944 GLY 1945 0.0397

GLY 1945 VAL 1946 0.0666

VAL 1946 VAL 1947 0.0710

VAL 1947 ARG 1948 0.0089

ARG 1948 ARG 1949 0.0992

ARG 1949 VAL 1950 0.0460

VAL 1950 GLY 1951 0.1019

GLY 1951 PRO 1952 0.0986

PRO 1952 SER 1953 0.0118

SER 1953 SER 1954 0.0985

SER 1954 ALA 1955 0.0978

ALA 1955 GLY 1956 0.0309

GLY 1956 HIS 1957 0.0722

HIS 1957 ASN 1958 0.0997

ASN 1958 ILE 1959 0.0485

ILE 1959 LYS 1960 0.0302

LYS 1960 VAL 1961 0.0226

VAL 1961 GLY 1962 0.1011

GLY 1962 ASP 1963 0.0070

ASP 1963 ARG 1964 0.0942

ARG 1964 VAL 1965 0.1512

VAL 1965 CYS 1966 0.0756

CYS 1966 ALA 1967 0.0852

ALA 1967 LEU 1968 0.0779

LEU 1968 LEU 1969 0.0320

LEU 1969 GLY 1970 0.0836

GLY 1970 GLY 1971 0.0722

GLY 1971 GLN 1972 0.0173

GLN 1972 TRP 1973 0.0750

TRP 1973 THR 1974 0.0466

THR 1974 ASN 1975 0.0683

ASN 1975 THR 1976 0.0799

THR 1976 VAL 1977 0.0217

VAL 1977 ARG 1978 0.0797

ARG 1978 VAL 1979 0.0045

VAL 1979 HIS 1980 0.0532

HIS 1980 TRP 1981 0.0686

TRP 1981 HIS 1982 0.0172

HIS 1982 SER 1983 0.0827

SER 1983 VAL 1984 0.0848

VAL 1984 ALA 1985 0.0618

ALA 1985 PRO 1986 0.0848

PRO 1986 ILE 1987 0.0881

ILE 1987 PRO 1988 0.0774

PRO 1988 GLN 1989 0.0452

GLN 1989 ALA 1990 0.0811

ALA 1990 MET 1991 0.0886

MET 1991 ASP 1992 0.0346

ASP 1992 TRP 1993 0.0667

TRP 1993 GLU 1994 0.0819

GLU 1994 THR 1995 0.0050

THR 1995 ALA 1996 0.0864

ALA 1996 ALA 1997 0.0469

ALA 1997 SER 1998 0.0447

SER 1998 ILE 1999 0.0380

ILE 1999 PRO 2000 0.0599

PRO 2000 ILE 2001 0.0650

ILE 2001 VAL 2002 0.0374

VAL 2002 PHE 2003 0.0279

PHE 2003 VAL 2004 0.0629

VAL 2004 THR 2005 0.0667

THR 2005 ALA 2006 0.0142

ALA 2006 TYR 2007 0.0550

TYR 2007 ILE 2008 0.0599

ILE 2008 SER 2009 0.0640

SER 2009 LEU 2010 0.0118

LEU 2010 VAL 2011 0.0598

VAL 2011 LYS 2012 0.0553

LYS 2012 ILE 2013 0.3015

ILE 2013 ALA 2014 0.0184

ALA 2014 ARG 2015 0.0182

ARG 2015 MET 2016 0.0243

MET 2016 GLN 2017 0.0013

GLN 2017 ALA 2018 0.0146

ALA 2018 GLY 2019 0.0324

GLY 2019 GLU 2020 0.0088

GLU 2020 THR 2021 0.0286

THR 2021 VAL 2022 0.0053

VAL 2022 LEU 2023 0.0201

LEU 2023 ILE 2024 0.0213

ILE 2024 HIS 2025 0.0123

HIS 2025 ALA 2026 0.0296

ALA 2026 ALA 2027 0.0097

ALA 2027 SER 2028 0.0339

SER 2028 GLY 2029 0.0025

GLY 2029 GLY 2030 0.0596

GLY 2030 VAL 2031 0.0548

VAL 2031 GLY 2032 0.0351

GLY 2032 GLN 2033 0.0503

GLN 2033 ALA 2034 0.0595

ALA 2034 ALA 2035 0.0484

ALA 2035 ILE 2036 0.0337

ILE 2036 ILE 2037 0.0581

ILE 2037 LEU 2038 0.0588

LEU 2038 ALA 2039 0.0427

ALA 2039 LYS 2040 0.0378

LYS 2040 HIS 2041 0.0596

HIS 2041 VAL 2042 0.0556

VAL 2042 GLY 2043 0.0343

GLY 2043 ALA 2044 0.0489

ALA 2044 GLU 2045 -0.0652

GLU 2045 ILE 2046 0.0167

ILE 2046 PHE 2047 0.0413

PHE 2047 ALA 2048 0.0157

ALA 2048 THR 2049 0.0232

THR 2049 VAL 2050 0.0363

VAL 2050 GLY 2051 0.0250

GLY 2051 THR 2052 0.0440

THR 2052 ASP 2053 0.0150

ASP 2053 GLU 2054 0.0459

GLU 2054 LYS 2055 0.0493

LYS 2055 ARG 2056 0.0094

ARG 2056 ASP 2057 0.0425

ASP 2057 LEU 2058 0.0432

LEU 2058 LEU 2059 0.0388

LEU 2059 ILE 2060 0.0126

ILE 2060 LYS 2061 0.0923

LYS 2061 GLU 2062 0.0453

GLU 2062 TYR 2063 0.0520

TYR 2063 LYS 2064 0.0154

LYS 2064 ILE 2065 0.0472

ILE 2065 PRO 2066 0.0375

PRO 2066 ASP 2067 0.0422

ASP 2067 ASP 2068 0.0520

ASP 2068 HIS 2069 0.0398

HIS 2069 ILE 2070 0.0167

ILE 2070 PHE 2071 0.0305

PHE 2071 SER 2072 0.0097

SER 2072 SER 2073 0.0228

SER 2073 ARG 2074 0.0359

ARG 2074 ASN 2075 0.0439

ASN 2075 ALA 2076 0.0465

ALA 2076 LEU 2077 0.0708

LEU 2077 PHE 2078 0.0270

PHE 2078 ALA 2079 0.0342

ALA 2079 LYS 2080 0.0252

LYS 2080 SER 2081 0.0205

SER 2081 ILE 2082 0.0330

ILE 2082 ARG 2083 0.0332

ARG 2083 GLN 2084 0.0200

GLN 2084 ARG 2085 0.0268

ARG 2085 THR 2086 0.0341

THR 2086 ASN 2087 0.0292

ASN 2087 GLY 2088 0.0083

GLY 2088 LYS 2089 0.0341

LYS 2089 GLY 2090 0.0155

GLY 2090 VAL 2091 0.0340

VAL 2091 ASP 2092 0.0340

ASP 2092 VAL 2093 -0.0371

VAL 2093 VAL 2094 0.0055

VAL 2094 LEU 2095 0.0216

LEU 2095 ASN 2096 0.0035

ASN 2096 CYS 2097 0.0088

CYS 2097 LEU 2098 0.0230

LEU 2098 ALA 2099 0.0093

ALA 2099 GLY 2100 0.0248

GLY 2100 GLY 2101 0.0214

GLY 2101 LEU 2102 0.0135

LEU 2102 LEU 2103 0.0267

LEU 2103 GLN 2104 0.0275

GLN 2104 GLU 2105 0.0186

GLU 2105 SER 2106 0.0202

SER 2106 PHE 2107 0.0280

PHE 2107 ASP 2108 0.0261

ASP 2108 CYS 2109 0.0002

CYS 2109 LEU 2110 0.0240

LEU 2110 ALA 2111 0.0082

ALA 2111 ASP 2112 0.0290

ASP 2112 PHE 2113 0.0302

PHE 2113 GLY 2114 0.0259

GLY 2114 ARG 2115 0.0242

ARG 2115 PHE 2116 0.0056

PHE 2116 ILE 2117 0.0286

ILE 2117 GLU 2118 0.0021

GLU 2118 ILE 2119 0.0291

ILE 2119 GLY 2120 0.0054

GLY 2120 LYS 2121 0.0129

LYS 2121 ARG 2122 0.0147

ARG 2122 ASP 2123 0.0300

ASP 2123 ILE 2124 0.0290

ILE 2124 GLU 2125 0.0552

GLU 2125 LEU 2126 0.0039

LEU 2126 ASN 2127 0.0113

ASN 2127 HIS 2128 0.0111

HIS 2128 CYS 2129 0.0113

CYS 2129 LEU 2130 0.0044

LEU 2130 ASN 2131 0.0109

ASN 2131 MET 2132 0.0100

MET 2132 GLY 2133 0.0109

GLY 2133 MET 2134 0.0013

MET 2134 PHE 2135 0.0102

PHE 2135 ALA 2136 0.0109

ALA 2136 ARG 2137 0.0033

ARG 2137 SER 2138 0.0088

SER 2138 ALA 2139 0.0113

ALA 2139 THR 2140 0.0107

THR 2140 PHE 2141 0.0125

PHE 2141 THR 2142 0.0358

THR 2142 ALA 2143 0.0016

ALA 2143 VAL 2144 0.0500

VAL 2144 ASP 2145 0.0067

ASP 2145 LEU 2146 0.0523

LEU 2146 ILE 2147 0.0149

ILE 2147 ALA 2148 0.0430

ALA 2148 ILE 2149 0.0256

ILE 2149 GLY 2150 0.0301

GLY 2150 ARG 2151 0.0426

ARG 2151 ASP 2152 0.0217

ASP 2152 ARG 2153 0.0220

ARG 2153 SER 2154 0.0461

SER 2154 TYR 2155 0.0156

TYR 2155 MET 2156 0.0465

MET 2156 PHE 2157 0.1772

PHE 2157 ALA 2158 0.0707

ALA 2158 GLU 2159 0.0014

GLU 2159 ALA 2160 0.0708

ALA 2160 LEU 2161 0.0376

LEU 2161 PRO 2162 0.0662

PRO 2162 LYS 2163 0.0058

LYS 2163 ILE 2164 0.0675

ILE 2164 MET 2165 0.0546

MET 2165 THR 2166 0.0282

THR 2166 LEU 2167 0.0468

LEU 2167 LEU 2168 0.0433

LEU 2168 GLN 2169 0.0705

GLN 2169 GLU 2170 0.0008

GLU 2170 LYS 2171 0.0710

LYS 2171 ALA 2172 0.0445

ALA 2172 ILE 2173 0.0912

ILE 2173 ARG 2174 0.0330

ARG 2174 PRO 2175 0.0127

PRO 2175 VAL 2176 0.0598

VAL 2176 THR 2177 0.0588

THR 2177 PRO 2178 0.0286

PRO 2178 ILE 2179 0.0221

ILE 2179 SER 2180 0.0263

SER 2180 ILE 2181 0.0194

ILE 2181 TYR 2182 0.0119

TYR 2182 LYS 2183 0.0148

LYS 2183 ILE 2184 0.0492

ILE 2184 GLY 2185 0.0295

GLY 2185 ASP 2186 0.0344

ASP 2186 ILE 2187 0.0528

ILE 2187 GLU 2188 0.0593

GLU 2188 THR 2189 0.1546

THR 2189 ALA 2190 0.0315

ALA 2190 PHE 2191 0.0658

PHE 2191 ARG 2192 0.0673

ARG 2192 LEU 2193 0.0210

LEU 2193 MET 2194 0.0550

MET 2194 GLN 2195 0.0586

GLN 2195 ALA 2196 0.0583

ALA 2196 GLY 2197 0.0156

GLY 2197 LYS 2198 0.0662

LYS 2198 HIS 2199 0.0659

HIS 2199 MET 2200 0.0156

MET 2200 GLY 2201 0.0654

GLY 2201 LYS 2202 0.0249

LYS 2202 ILE 2203 0.0027

ILE 2203 VAL 2204 0.0556

VAL 2204 ILE 2205 0.2843

ILE 2205 THR 2206 0.0676

THR 2206 ALA 2207 0.0248

ALA 2207 PRO 2208 0.0733

PRO 2208 GLU 2209 0.0210

GLU 2209 ASP 2210 0.0838

ASP 2210 ALA 2211 0.0731

ALA 2211 MET 2212 0.0760

MET 2212 VAL 2213 0.0891

VAL 2213 PRO 2214 0.0915

PRO 2214 VAL 2215 0.0888

VAL 2215 ILE 2216 0.0925

ILE 2216 THR 2217 0.0578

THR 2217 ARG 2218 0.0981

ARG 2218 PRO 2219 0.0354

PRO 2219 PRO 2220 0.1020

PRO 2220 LYS 2221 0.9978

LYS 2221 LEU 2222 0.1230

LEU 2222 GLN 2223 0.0798

GLN 2223 LEU 2224 0.1288

LEU 2224 ARG 2225 0.1138

ARG 2225 PRO 2226 0.0753

PRO 2226 ASP 2227 0.1335

ASP 2227 ALA 2228 0.0104

ALA 2228 SER 2229 0.0973

SER 2229 TYR 2230 0.0783

TYR 2230 LEU 2231 0.0587

LEU 2231 ILE 2232 0.1182

ILE 2232 VAL 2233 0.0456

VAL 2233 GLY 2234 0.1372

GLY 2234 GLY 2235 0.0074

GLY 2235 LEU 2236 0.1355

LEU 2236 GLY 2237 -0.1038

GLY 2237 GLY 2238 0.1100

GLY 2238 ILE 2239 0.1065

ILE 2239 GLY 2240 0.1011

GLY 2240 ARG 2241 0.0233

ARG 2241 SER 2242 0.1148

SER 2242 LEU 2243 0.1096

LEU 2243 CYS 2244 0.0537

CYS 2244 LYS 2245 0.0681

LYS 2245 ASN 2246 0.1014

ASN 2246 PHE 2247 0.1151

PHE 2247 VAL 2248 0.0127

VAL 2248 GLU 2249 0.1078

GLU 2249 ASN 2250 0.0902

ASN 2250 GLY 2251 0.0886

GLY 2251 ALA 2252 0.0934

ALA 2252 ARG 2253 0.1919

ARG 2253 SER 2254 0.0775

SER 2254 LEU 2255 0.0658

LEU 2255 VAL 2256 0.0709

VAL 2256 LEU 2257 0.1174

LEU 2257 LEU 2258 0.0378

LEU 2258 SER 2259 0.1280

SER 2259 ARG 2260 0.0946

ARG 2260 ASN 2261 0.0767

ASN 2261 ALA 2262 0.0371

ALA 2262 ASN 2263 0.1217

ASN 2263 VAL 2264 0.1410

VAL 2264 SER 2265 0.0233

SER 2265 GLN 2266 0.1304

GLN 2266 GLN 2267 0.1160

GLN 2267 SER 2268 0.1385

SER 2268 GLY 2269 0.0884

GLY 2269 GLU 2270 0.1245

GLU 2270 PHE 2271 0.0980

PHE 2271 LEU 2272 0.1523

LEU 2272 ASP 2273 0.0015

ASP 2273 GLU 2274 0.1531

GLU 2274 LEU 2275 0.1202

LEU 2275 ARG 2276 0.1027

ARG 2276 SER 2277 0.0588

SER 2277 THR 2278 0.1413

THR 2278 GLY 2279 0.1527

GLY 2279 CYS 2280 0.0025

CYS 2280 ILE 2281 0.1365

ILE 2281 VAL 2282 0.0861

VAL 2282 GLY 2283 0.1014

GLY 2283 VAL 2284 0.1126

VAL 2284 VAL 2285 -0.0341

VAL 2285 ASP 2286 0.0662

ASP 2286 CYS 2287 0.0488

CYS 2287 ASP 2288 0.0263

ASP 2288 ILE 2289 0.1308

ILE 2289 SER 2290 0.0090

SER 2290 SER 2291 0.1361

SER 2291 LYS 2292 0.1366

LYS 2292 THR 2293 0.1156

THR 2293 GLN 2294 0.0595

GLN 2294 VAL 2295 0.1345

VAL 2295 GLU 2296 0.1368

GLU 2296 ALA 2297 0.0879

ALA 2297 THR 2298 0.0932

THR 2298 MET 2299 0.1367

MET 2299 LEU 2300 0.1304

LEU 2300 ARG 2301 0.0159

ARG 2301 LEU 2302 0.1185

LEU 2302 LYS 2303 0.1272

LYS 2303 LYS 2304 0.0716

LYS 2304 ASP 2305 0.0991

ASP 2305 MET 2306 0.1276

MET 2306 LEU 2307 0.1250

LEU 2307 PRO 2308 0.0480

PRO 2308 ILE 2309 0.0744

ILE 2309 ARG 2310 0.1268

ARG 2310 GLY 2311 0.1015

GLY 2311 ILE 2312 0.0828

ILE 2312 VAL 2313 0.1211

VAL 2313 HIS 2314 0.0556

HIS 2314 ALA 2315 0.1266

ALA 2315 GLY 2316 0.0999

GLY 2316 MET 2317 0.1022

MET 2317 VAL 2318 0.0662

VAL 2318 LEU 2319 0.0841

LEU 2319 GLN 2320 0.0304

GLN 2320 ASP 2321 0.0897

ASP 2321 SER 2322 0.0109

SER 2322 VAL 2323 0.0560

VAL 2323 PHE 2324 0.0665

PHE 2324 GLU 2325 0.0350

GLU 2325 ARG 2326 0.0756

ARG 2326 MET 2327 0.0690

MET 2327 SER 2328 0.0896

SER 2328 LEU 2329 0.0956

LEU 2329 ASP 2330 0.0391

ASP 2330 ASP 2331 0.0708

ASP 2331 TYR 2332 0.0908

TYR 2332 ASN 2333 0.0357

ASN 2333 THR 2334 0.0254

THR 2334 ALA 2335 0.0945

ALA 2335 ILE 2336 0.0901

ILE 2336 ARG 2337 0.0928

ARG 2337 PRO 2338 0.0088

PRO 2338 LYS 2339 0.0985

LYS 2339 VAL 2340 0.0364

VAL 2340 GLN 2341 0.1022

GLN 2341 GLY 2342 0.0008

GLY 2342 SER 2343 0.1007

SER 2343 TRP 2344 0.0597

TRP 2344 ASN 2345 0.0846

ASN 2345 LEU 2346 0.0255

LEU 2346 HIS 2347 0.0862

HIS 2347 SER 2348 0.0882

SER 2348 GLY 2349 0.0618

GLY 2349 LEU 2350 0.0768

LEU 2350 SER 2351 0.0847

SER 2351 ASP 2352 0.0421

ASP 2352 CYS 2353 0.0700

CYS 2353 ASP 2354 0.1015

ASP 2354 LEU 2355 0.1085

LEU 2355 ASP 2356 0.0924

ASP 2356 PHE 2357 0.0686

PHE 2357 PHE 2358 0.0501

PHE 2358 ILE 2359 0.1051

ILE 2359 MET 2360 0.0538

MET 2360 LEU 2361 0.1087

LEU 2361 SER 2362 0.0042

SER 2362 SER 2363 0.0959

SER 2363 LEU 2364 0.0914

LEU 2364 ALA 2365 0.0843

ALA 2365 GLY 2366 0.0701

GLY 2366 VAL 2367 0.0939

VAL 2367 SER 2368 0.0937

SER 2368 GLY 2369 0.0633

GLY 2369 SER 2370 0.0859

SER 2370 ALA 2371 0.0618

ALA 2371 SER 2372 0.0933

SER 2372 GLN 2373 0.0805

GLN 2373 ALA 2374 0.0322

ALA 2374 ASN 2375 0.0868

ASN 2375 TYR 2376 0.0117

TYR 2376 THR 2377 0.0870

THR 2377 ALA 2378 0.0574

ALA 2378 GLY 2379 0.0435

GLY 2379 GLY 2380 0.0646

GLY 2380 ALA 2381 0.0424

ALA 2381 TYR 2382 0.0898

TYR 2382 GLN 2383 0.0061

GLN 2383 ASP 2384 0.0883

ASP 2384 ALA 2385 0.0388

ALA 2385 LEU 2386 0.0674

LEU 2386 ALA 2387 0.0415

ALA 2387 LYS 2388 0.0538

LYS 2388 TYR 2389 0.0763

TYR 2389 ARG 2390 0.0208

ARG 2390 ARG 2391 0.0847

ARG 2391 ALA 2392 0.0222

ALA 2392 GLN 2393 0.0858

GLN 2393 GLY 2394 0.0215

GLY 2394 LEU 2395 0.0697

LEU 2395 SER 2396 0.0485

SER 2396 ALA 2397 0.0748

ALA 2397 VAL 2398 0.0776

VAL 2398 SER 2399 0.0568

SER 2399 ILE 2400 0.0642

ILE 2400 ASP 2401 0.0430

ASP 2401 LEU 2402 0.0408

LEU 2402 GLY 2403 0.0767

GLY 2403 MET 2404 0.0667

MET 2404 VAL 2405 0.0051

VAL 2405 GLN 2406 0.0604

GLN 2406 SER 2407 0.0203

SER 2407 VAL 2408 0.0740

VAL 2408 GLY 2409 0.0352

GLY 2409 TYR 2410 0.0246

TYR 2410 VAL 2411 0.0771

VAL 2411 ALA 2412 0.0072

ALA 2412 GLU 2413 0.1395

GLU 2413 THR 2414 0.0199

THR 2414 LYS 2415 0.0765

LYS 2415 GLY 2416 0.0427

GLY 2416 VAL 2417 0.0720

VAL 2417 ALA 2418 0.0546

ALA 2418 GLU 2419 0.0669

GLU 2419 ARG 2420 0.0109

ARG 2420 LEU 2421 0.0748

LEU 2421 VAL 2422 0.0650

VAL 2422 ARG 2423 0.0286

ARG 2423 MET 2424 0.0530

MET 2424 GLY 2425 0.0611

GLY 2425 TYR 2426 0.0437

TYR 2426 SER 2427 0.0124

SER 2427 PRO 2428 0.0302

PRO 2428 ILE 2429 0.0981

ILE 2429 SER 2430 0.0048

SER 2430 GLU 2431 0.0499

GLU 2431 MET 2432 0.0447

MET 2432 GLU 2433 0.0181

GLU 2433 VAL 2434 0.0453

VAL 2434 LEU 2435 0.0259

LEU 2435 LYS 2436 0.0567

LYS 2436 ILE 2437 0.0013

ILE 2437 VAL 2438 0.0561

VAL 2438 GLU 2439 0.0243

GLU 2439 HIS 2440 0.0404

HIS 2440 ALA 2441 0.0234

ALA 2441 ILE 2442 0.0357

ILE 2442 THR 2443 0.0458

THR 2443 ASN 2444 0.0233

ASN 2444 PRO 2445 0.2013

PRO 2445 PRO 2446 0.0180

PRO 2446 PRO 2447 0.0571

PRO 2447 GLU 2448 0.0018

GLU 2448 ALA 2449 0.0457

ALA 2449 SER 2450 0.0536

SER 2450 SER 2451 0.0102

SER 2451 ALA 2452 0.0591

ALA 2452 GLN 2453 0.0614

GLN 2453 ILE 2454 0.0337

ILE 2454 ILE 2455 0.0565

ILE 2455 THR 2456 0.0337

THR 2456 GLY 2457 0.0619

GLY 2457 ILE 2458 0.0345

ILE 2458 SER 2459 0.0578

SER 2459 THR 2460 0.0616

THR 2460 LYS 2461 0.1045

LYS 2461 PRO 2462 0.0516

PRO 2462 GLY 2463 0.0540

GLY 2463 ARG 2464 0.0359

ARG 2464 HIS 2465 0.0477

HIS 2465 TRP 2466 0.0396

TRP 2466 THR 2467 0.0441

THR 2467 GLU 2468 0.0554

GLU 2468 SER 2469 0.0531

SER 2469 SER 2470 0.0010

SER 2470 TRP 2471 0.0554

TRP 2471 LEU 2472 0.0416

LEU 2472 GLN 2473 0.0212

GLN 2473 ASP 2474 0.0399

ASP 2474 ALA 2475 0.0522

ALA 2475 ARG 2476 0.0429

ARG 2476 PHE 2477 -0.0439

PHE 2477 ALA 2478 0.0229

ALA 2478 THR 2479 0.0185

THR 2479 LEU 2480 0.0069

LEU 2480 ARG 2481 0.0247

ARG 2481 GLU 2482 0.0249

GLU 2482 ARG 2483 0.0083

ARG 2483 ALA 2484 0.0205

ALA 2484 ARG 2485 0.0223

ARG 2485 ASP 2486 0.0226

ASP 2486 VAL 2487 0.0047

VAL 2487 LYS 2488 0.0248

LYS 2488 GLU 2489 0.0231

GLU 2489 LEU 2490 0.0146

LEU 2490 SER 2491 0.0141

SER 2491 ASN 2492 0.0226

ASN 2492 SER 2493 -0.0925

SER 2493 GLN 2494 0.0346

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** sdgklnrdh ***

CA strain for 22101813491974862

--- normal mode 21 ---

Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *