Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *

CA strain for 22101813491974862

--- normal mode 19 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
ASN 989 LYS 990 0.1216

LYS 990 ALA 991 0.0289

ALA 991 HIS 992 0.1066

HIS 992 ARG 993 0.0674

ARG 993 GLN 994 0.0740

GLN 994 ARG 995 0.0733

ARG 995 VAL 996 0.1039

VAL 996 HIS 997 0.0972

HIS 997 PRO 998 0.1049

PRO 998 PRO 999 0.1019

PRO 999 HIS 1000 0.0415

HIS 1000 ASP 1001 0.1168

ASP 1001 LEU 1002 0.0199

LEU 1002 LEU 1003 0.1237

LEU 1003 GLY 1004 0.0204

GLY 1004 SER 1005 0.1497

SER 1005 LEU 1006 0.0819

LEU 1006 ILE 1007 0.0957

ILE 1007 VAL 1008 0.0706

VAL 1008 GLY 1009 0.0923

GLY 1009 ARG 1010 0.0040

ARG 1010 ASP 1011 0.0581

ASP 1011 LEU 1012 0.0970

LEU 1012 ARG 1013 0.0081

ARG 1013 GLU 1014 0.0996

GLU 1014 PRO 1015 0.0492

PRO 1015 THR 1016 0.0917

THR 1016 TRP 1017 0.0730

TRP 1017 ARG 1018 0.0713

ARG 1018 HIS 1019 0.0975

HIS 1019 PHE 1020 0.0721

PHE 1020 ILE 1021 -0.2374

ILE 1021 ARG 1022 0.0601

ARG 1022 VAL 1023 0.0504

VAL 1023 GLN 1024 0.0254

GLN 1024 ASP 1025 0.0674

ASP 1025 ILE 1026 0.0024

ILE 1026 PRO 1027 0.0585

PRO 1027 TRP 1028 0.0112

TRP 1028 ILE 1029 0.0662

ILE 1029 ARG 1030 0.0674

ARG 1030 ASP 1031 0.0190

ASP 1031 HIS 1032 0.0566

HIS 1032 VAL 1033 0.0635

VAL 1033 VAL 1034 0.0381

VAL 1034 GLN 1035 0.0642

GLN 1035 SER 1036 0.0290

SER 1036 ALA 1037 -0.1378

ALA 1037 LEU 1038 0.0570

LEU 1038 VAL 1039 0.0532

VAL 1039 TYR 1040 0.0662

TYR 1040 PRO 1041 0.0209

PRO 1041 GLY 1042 0.0504

GLY 1042 ALA 1043 0.0692

ALA 1043 GLY 1044 0.0007

GLY 1044 PHE 1045 0.0691

PHE 1045 ILE 1046 0.0482

ILE 1046 CYS 1047 0.0422

CYS 1047 MET 1048 0.0314

MET 1048 ALA 1049 0.0538

ALA 1049 MET 1050 0.0680

MET 1050 GLU 1051 0.0062

GLU 1051 ALA 1052 0.0643

ALA 1052 MET 1053 -0.1071

MET 1053 VAL 1054 0.0680

VAL 1054 GLN 1055 0.0120

GLN 1055 LEU 1056 0.0751

LEU 1056 HIS 1057 0.0698

HIS 1057 GLU 1058 0.0270

GLU 1058 LEU 1059 0.0571

LEU 1059 ARG 1060 0.0579

ARG 1060 ASP 1061 0.0695

ASP 1061 SER 1062 0.0527

SER 1062 GLN 1063 0.0253

GLN 1063 SER 1064 0.0697

SER 1064 ARG 1065 0.0097

ARG 1065 LYS 1066 0.0676

LYS 1066 VAL 1067 0.0712

VAL 1067 ALA 1068 0.0064

ALA 1068 GLY 1069 0.0416

GLY 1069 TYR 1070 0.0662

TYR 1070 ARG 1071 0.0344

ARG 1071 LEU 1072 0.0669

LEU 1072 ALA 1073 0.0393

ALA 1073 GLU 1074 0.0653

GLU 1074 VAL 1075 0.0434

VAL 1075 ASP 1076 0.0667

ASP 1076 ILE 1077 0.0527

ILE 1077 LEU 1078 0.0648

LEU 1078 ARG 1079 0.0469

ARG 1079 ALA 1080 0.0593

ALA 1080 MET 1081 0.0033

MET 1081 LEU 1082 0.0561

LEU 1082 ILE 1083 0.0270

ILE 1083 PRO 1084 0.0357

PRO 1084 ASP 1085 0.1215

ASP 1085 THR 1086 0.0292

THR 1086 SER 1087 0.0433

SER 1087 GLU 1088 0.0787

GLU 1088 GLY 1089 0.0085

GLY 1089 LEU 1090 0.0425

LEU 1090 GLU 1091 0.0877

GLU 1091 ALA 1092 0.0245

ALA 1092 HIS 1093 0.0803

HIS 1093 ILE 1094 0.0449

ILE 1094 SER 1095 0.0823

SER 1095 LEU 1096 0.0575

LEU 1096 ARG 1097 0.0703

ARG 1097 PRO 1098 0.0599

PRO 1098 CYS 1099 0.0103

CYS 1099 SER 1100 0.0814

SER 1100 THR 1101 0.0564

THR 1101 LYS 1102 0.0424

LYS 1102 LEU 1103 0.0675

LEU 1103 LEU 1104 0.0334

LEU 1104 LEU 1105 0.0555

LEU 1105 THR 1106 0.0723

THR 1106 ASN 1107 0.0183

ASN 1107 GLU 1108 0.0110

GLU 1108 TRP 1109 0.0724

TRP 1109 TYR 1110 0.0292

TYR 1110 ASP 1111 0.0726

ASP 1111 PHE 1112 0.0409

PHE 1112 CYS 1113 0.0602

CYS 1113 VAL 1114 0.0487

VAL 1114 SER 1115 0.0503

SER 1115 SER 1116 0.0253

SER 1116 VAL 1117 -0.0497

VAL 1117 GLY 1118 0.0743

GLY 1118 ASP 1119 0.0244

ASP 1119 ASP 1120 0.0695

ASP 1120 ASP 1121 0.0760

ASP 1121 LYS 1122 0.0006

LYS 1122 PHE 1123 0.0531

PHE 1123 VAL 1124 0.0381

VAL 1124 ASP 1125 0.0377

ASP 1125 HIS 1126 0.0706

HIS 1126 CYS 1127 0.0508

CYS 1127 ARG 1128 0.0597

ARG 1128 GLY 1129 0.0512

GLY 1129 ARG 1130 0.0749

ARG 1130 ILE 1131 0.0660

ILE 1131 THR 1132 0.0756

THR 1132 ILE 1133 0.0721

ILE 1133 GLU 1134 0.0210

GLU 1134 PHE 1135 0.0428

PHE 1135 ASP 1136 0.0357

ASP 1136 THR 1137 0.0389

THR 1137 SER 1138 0.0461

SER 1138 GLY 1139 0.0073

GLY 1139 SER 1140 0.0343

SER 1140 ALA 1141 0.0272

ALA 1141 ASP 1142 0.0470

ASP 1142 THR 1143 0.0357

THR 1143 PRO 1144 0.0377

PRO 1144 ARG 1145 0.0423

ARG 1145 THR 1146 0.0116

THR 1146 SER 1147 0.0476

SER 1147 LEU 1148 0.0475

LEU 1148 ARG 1149 0.3097

ARG 1149 GLU 1150 0.0466

GLU 1150 ARG 1151 0.0447

ARG 1151 SER 1152 0.0282

SER 1152 ARG 1153 0.0172

ARG 1153 SER 1154 0.0448

SER 1154 THR 1155 0.0086

THR 1155 GLY 1156 0.0467

GLY 1156 LEU 1157 0.0448

LEU 1157 MET 1158 0.0201

MET 1158 ARG 1159 0.0467

ARG 1159 SER 1160 0.0388

SER 1160 VAL 1161 0.0283

VAL 1161 ASP 1162 0.0391

ASP 1162 PRO 1163 0.0005

PRO 1163 SER 1164 0.0469

SER 1164 ASN 1165 0.2803

ASN 1165 LEU 1166 0.0328

LEU 1166 TYR 1167 0.0115

TYR 1167 SER 1168 0.0413

SER 1168 PHE 1169 0.0419

PHE 1169 LEU 1170 0.0132

LEU 1170 ARG 1171 0.0342

ARG 1171 ALA 1172 0.0338

ALA 1172 GLN 1173 0.0418

GLN 1173 GLY 1174 0.0042

GLY 1174 ILE 1175 0.0448

ILE 1175 TYR 1176 0.0426

TYR 1176 HIS 1177 0.0451

HIS 1177 GLY 1178 0.0400

GLY 1178 PRO 1179 0.0411

PRO 1179 ILE 1180 0.0324

ILE 1180 PHE 1181 -0.0254

PHE 1181 GLN 1182 0.0120

GLN 1182 ASN 1183 0.0522

ASN 1183 LEU 1184 0.0051

LEU 1184 LYS 1185 0.0313

LYS 1185 THR 1186 0.0120

THR 1186 ILE 1187 0.0478

ILE 1187 SER 1188 0.0137

SER 1188 SER 1189 0.0531

SER 1189 ARG 1190 0.0304

ARG 1190 LYS 1191 0.0546

LYS 1191 ASP 1192 0.0356

ASP 1192 HIS 1193 0.0477

HIS 1193 SER 1194 0.0478

SER 1194 GLU 1195 0.0506

GLU 1195 SER 1196 0.0250

SER 1196 SER 1197 0.0922

SER 1197 PHE 1198 0.0051

PHE 1198 VAL 1199 0.0295

VAL 1199 VAL 1200 0.0109

VAL 1200 ALA 1201 0.0469

ALA 1201 ASN 1202 0.0259

ASN 1202 THR 1203 0.0449

THR 1203 ALA 1204 0.0259

ALA 1204 SER 1205 0.0690

SER 1205 VAL 1206 0.0659

VAL 1206 MET 1207 0.0293

MET 1207 PRO 1208 0.0109

PRO 1208 ASN 1209 0.0692

ASN 1209 GLY 1210 0.0126

GLY 1210 PHE 1211 0.0604

PHE 1211 GLN 1212 0.0518

GLN 1212 SER 1213 0.0579

SER 1213 PRO 1214 0.0377

PRO 1214 HIS 1215 0.0293

HIS 1215 VAL 1216 0.0193

VAL 1216 ILE 1217 0.0475

ILE 1217 HIS 1218 0.0579

HIS 1218 PRO 1219 0.0605

PRO 1219 THR 1220 0.0517

THR 1220 THR 1221 0.0407

THR 1221 LEU 1222 0.0602

LEU 1222 ASP 1223 0.0630

ASP 1223 SER 1224 0.0401

SER 1224 ILE 1225 0.0450

ILE 1225 PHE 1226 0.0637

PHE 1226 GLN 1227 0.0592

GLN 1227 GLY 1228 0.0279

GLY 1228 ALA 1229 0.0864

ALA 1229 TYR 1230 0.0331

TYR 1230 THR 1231 0.0199

THR 1231 ALA 1232 0.0379

ALA 1232 LEU 1233 0.0416

LEU 1233 PRO 1234 0.0076

PRO 1234 GLY 1235 0.0413

GLY 1235 ALA 1236 0.0167

ALA 1236 GLY 1237 0.0282

GLY 1237 LEU 1238 0.0364

LEU 1238 ASP 1239 0.0381

ASP 1239 GLN 1240 0.0088

GLN 1240 ASN 1241 0.0398

ASN 1241 THR 1242 0.0020

THR 1242 ALA 1243 0.0202

ALA 1243 MET 1244 0.0407

MET 1244 ILE 1245 -0.2537

ILE 1245 PRO 1246 0.0575

PRO 1246 ARG 1247 0.0571

ARG 1247 SER 1248 0.0565

SER 1248 ILE 1249 0.0547

ILE 1249 GLN 1250 0.0482

GLN 1250 GLU 1251 0.0549

GLU 1251 LEU 1252 0.0475

LEU 1252 TYR 1253 0.0570

TYR 1253 LEU 1254 0.0429

LEU 1254 SER 1255 0.0579

SER 1255 SER 1256 0.0184

SER 1256 ALA 1257 0.0392

ALA 1257 LEU 1258 0.0580

LEU 1258 THR 1259 0.0394

THR 1259 SER 1260 0.0416

SER 1260 ASP 1261 0.0891

ASP 1261 VAL 1262 0.0452

VAL 1262 GLY 1263 0.0041

GLY 1263 GLN 1264 0.0399

GLN 1264 CYS 1265 0.0167

CYS 1265 LEU 1266 0.0461

LEU 1266 VAL 1267 0.0172

VAL 1267 SER 1268 0.0456

SER 1268 ASP 1269 0.0243

ASP 1269 THR 1270 0.0442

THR 1270 SER 1271 0.0374

SER 1271 LEU 1272 0.0456

LEU 1272 ILE 1273 0.0436

ILE 1273 ARG 1274 0.0448

ARG 1274 TYR 1275 0.0459

TYR 1275 ASP 1276 0.0451

ASP 1276 GLY 1277 0.0619

GLY 1277 GLN 1278 0.0030

GLN 1278 SER 1279 0.0465

SER 1279 PHE 1280 0.0366

PHE 1280 THR 1281 0.0462

THR 1281 VAL 1282 0.0433

VAL 1282 ASN 1283 0.0471

ASN 1283 VAL 1284 0.0442

VAL 1284 ASP 1285 0.0458

ASP 1285 VAL 1286 0.0404

VAL 1286 SER 1287 0.0444

SER 1287 SER 1288 0.0452

SER 1288 LYS 1289 0.0202

LYS 1289 ALA 1290 0.0461

ALA 1290 ASP 1291 0.0457

ASP 1291 SER 1292 0.0046

SER 1292 GLU 1293 0.0295

GLU 1293 HIS 1294 0.0413

HIS 1294 THR 1295 0.0283

THR 1295 PRO 1296 0.0347

PRO 1296 VAL 1297 0.0046

VAL 1297 LEU 1298 0.0461

LEU 1298 GLU 1299 0.0376

GLU 1299 ILE 1300 0.0468

ILE 1300 LYS 1301 0.0396

LYS 1301 GLY 1302 0.0477

GLY 1302 LEU 1303 0.0377

LEU 1303 ARG 1304 0.0476

ARG 1304 ASN 1305 0.0465

ASN 1305 GLN 1306 0.0453

GLN 1306 SER 1307 0.0476

SER 1307 VAL 1308 0.0106

VAL 1308 GLY 1309 -1.3439

GLY 1309 GLN 1310 0.0471

GLN 1310 MET 1311 0.0015

MET 1311 ALA 1312 0.0589

ALA 1312 PRO 1313 0.0532

PRO 1313 GLN 1314 0.0031

GLN 1314 PRO 1315 0.0549

PRO 1315 GLY 1316 0.0589

GLY 1316 ASP 1317 0.0333

ASP 1317 SER 1318 0.0295

SER 1318 SER 1319 0.0533

SER 1319 ASN 1320 0.0535

ASN 1320 ASN 1321 0.0223

ASN 1321 ASP 1322 0.0478

ASP 1322 LEU 1323 0.0580

LEU 1323 CYS 1324 0.0602

CYS 1324 PHE 1325 -0.2670

PHE 1325 LYS 1326 0.0055

LYS 1326 LEU 1327 0.0064

LEU 1327 ASP 1328 0.0050

ASP 1328 TRP 1329 0.0063

TRP 1329 ALA 1330 0.0038

ALA 1330 PRO 1331 0.0064

PRO 1331 ASP 1332 0.0044

ASP 1332 ILE 1333 0.0023

ILE 1333 SER 1334 0.0061

SER 1334 SER 1335 0.0017

SER 1335 VAL 1336 0.0065

VAL 1336 LYS 1337 0.0063

LYS 1337 GLN 1338 0.0042

GLN 1338 GLU 1339 0.0033

GLU 1339 ARG 1340 0.0054

ARG 1340 LEU 1341 -0.0470

LEU 1341 LYS 1342 0.0065

LYS 1342 GLU 1343 0.0114

GLU 1343 LYS 1344 0.0154

LYS 1344 PHE 1345 0.0162

PHE 1345 GLY 1346 0.0103

GLY 1346 PHE 1347 0.0046

PHE 1347 PRO 1348 0.0038

PRO 1348 LEU 1349 0.0124

LEU 1349 ASP 1350 0.0097

ASP 1350 PRO 1351 0.0045

PRO 1351 THR 1352 0.0160

THR 1352 GLU 1353 0.0034

GLU 1353 ALA 1354 0.0158

ALA 1354 ASP 1355 0.0054

ASP 1355 ILE 1356 0.0120

ILE 1356 ILE 1357 0.0813

ILE 1357 MET 1358 0.0210

MET 1358 GLY 1359 0.0331

GLY 1359 LEU 1360 0.0052

LEU 1360 ARG 1361 0.0369

ARG 1361 GLN 1362 0.0105

GLN 1362 ALA 1363 0.0360

ALA 1363 CYS 1364 0.0071

CYS 1364 ILE 1365 0.0323

ILE 1365 HIS 1366 0.0238

HIS 1366 PHE 1367 0.0168

PHE 1367 ILE 1368 0.0269

ILE 1368 HIS 1369 0.0175

HIS 1369 ARG 1370 0.0358

ARG 1370 SER 1371 0.0036

SER 1371 LEU 1372 0.0369

LEU 1372 GLN 1373 0.0163

GLN 1373 SER 1374 0.0378

SER 1374 LEU 1375 0.0030

LEU 1375 THR 1376 0.0399

THR 1376 ALA 1377 0.0193

ALA 1377 PRO 1378 0.0289

PRO 1378 ASP 1379 0.0398

ASP 1379 ARG 1380 0.0352

ARG 1380 ASP 1381 0.0142

ASP 1381 GLN 1382 0.0385

GLN 1382 LEU 1383 0.0405

LEU 1383 ASP 1384 0.0114

ASP 1384 TRP 1385 0.0331

TRP 1385 HIS 1386 0.0334

HIS 1386 GLN 1387 0.0087

GLN 1387 LYS 1388 0.0402

LYS 1388 ARG 1389 0.0021

ARG 1389 PHE 1390 0.0137

PHE 1390 TYR 1391 0.0307

TYR 1391 ASP 1392 0.0365

ASP 1392 TRP 1393 0.0344

TRP 1393 MET 1394 0.0112

MET 1394 VAL 1395 0.0380

VAL 1395 LEU 1396 0.0376

LEU 1396 GLN 1397 0.0214

GLN 1397 ILE 1398 0.0203

ILE 1398 GLN 1399 0.0367

GLN 1399 LEU 1400 0.0383

LEU 1400 ALA 1401 0.0096

ALA 1401 GLU 1402 0.0344

GLU 1402 GLU 1403 0.0352

GLU 1403 ASP 1404 0.0287

ASP 1404 ARG 1405 -0.0160

ARG 1405 LEU 1406 0.0380

LEU 1406 ALA 1407 0.0139

ALA 1407 PRO 1408 0.0135

PRO 1408 ASN 1409 0.0271

ASN 1409 SER 1410 0.0206

SER 1410 SER 1411 0.0352

SER 1411 ALA 1412 0.0116

ALA 1412 TRP 1413 0.0271

TRP 1413 LEU 1414 0.0371

LEU 1414 GLN 1415 0.0014

GLN 1415 CYS 1416 0.0365

CYS 1416 SER 1417 0.0226

SER 1417 SER 1418 0.0328

SER 1418 SER 1419 0.0249

SER 1419 ASP 1420 0.0344

ASP 1420 GLU 1421 0.0129

GLU 1421 GLN 1422 0.0368

GLN 1422 LYS 1423 0.0311

LYS 1423 LEU 1424 0.0190

LEU 1424 LEU 1425 0.0179

LEU 1425 GLU 1426 0.0315

GLU 1426 ASN 1427 0.0369

ASN 1427 VAL 1428 0.0056

VAL 1428 ARG 1429 0.0323

ARG 1429 ALA 1430 0.0294

ALA 1430 SER 1431 0.0352

SER 1431 SER 1432 0.0002

SER 1432 VAL 1433 0.0118

VAL 1433 ASN 1434 0.0364

ASN 1434 GLY 1435 0.0093

GLY 1435 GLN 1436 0.0346

GLN 1436 MET 1437 0.0004

MET 1437 VAL 1438 0.0291

VAL 1438 VAL 1439 0.0153

VAL 1439 HIS 1440 0.0218

HIS 1440 VAL 1441 0.0196

VAL 1441 GLY 1442 0.0195

GLY 1442 LYS 1443 0.0242

LYS 1443 SER 1444 0.0113

SER 1444 MET 1445 0.0298

MET 1445 LEU 1446 0.0332

LEU 1446 ALA 1447 0.0296

ALA 1447 ILE 1448 0.0120

ILE 1448 LEU 1449 0.0340

LEU 1449 ARG 1450 0.0343

ARG 1450 HIS 1451 0.0168

HIS 1451 GLU 1452 0.0202

GLU 1452 ILE 1453 0.1616

ILE 1453 ALA 1454 0.0147

ALA 1454 PRO 1455 0.0292

PRO 1455 LEU 1456 0.0227

LEU 1456 GLU 1457 0.0312

GLU 1457 LEU 1458 0.0027

LEU 1458 MET 1459 0.0329

MET 1459 LEU 1460 0.0267

LEU 1460 GLN 1461 0.0138

GLN 1461 ASP 1462 0.0261

ASP 1462 LYS 1463 0.0177

LYS 1463 LEU 1464 0.0243

LEU 1464 LEU 1465 0.0114

LEU 1465 TYR 1466 0.0314

TYR 1466 ARG 1467 0.0044

ARG 1467 TYR 1468 0.0332

TYR 1468 TYR 1469 0.1276

TYR 1469 THR 1470 0.0142

THR 1470 ASP 1471 0.0000

ASP 1471 ALA 1472 0.0146

ALA 1472 ILE 1473 0.0121

ILE 1473 LYS 1474 0.0108

LYS 1474 TRP 1475 0.0050

TRP 1475 ASP 1476 0.0156

ASP 1476 ARG 1477 0.0155

ARG 1477 SER 1478 0.0049

SER 1478 TYR 1479 0.0124

TYR 1479 GLN 1480 0.0140

GLN 1480 GLN 1481 0.0137

GLN 1481 ILE 1482 0.0039

ILE 1482 ASP 1483 0.0158

ASP 1483 GLN 1484 0.0156

GLN 1484 LEU 1485 0.0957

LEU 1485 VAL 1486 0.0037

VAL 1486 LYS 1487 0.0036

LYS 1487 LEU 1488 0.0018

LEU 1488 HIS 1489 0.0035

HIS 1489 ALA 1490 0.0037

ALA 1490 HIS 1491 0.0024

HIS 1491 LYS 1492 0.0024

LYS 1492 CYS 1493 0.0037

CYS 1493 PRO 1494 0.0036

PRO 1494 THR 1495 0.0036

THR 1495 ALA 1496 0.0029

ALA 1496 LYS 1497 0.0030

LYS 1497 ILE 1498 0.0008

ILE 1498 ILE 1499 0.0017

ILE 1499 GLU 1500 0.0004

GLU 1500 ILE 1501 0.0778

ILE 1501 GLY 1502 0.0021

GLY 1502 ALA 1503 0.0053

ALA 1503 GLY 1504 0.0036

GLY 1504 THR 1505 0.0024

THR 1505 GLY 1506 0.0057

GLY 1506 GLY 1507 0.0052

GLY 1507 CYS 1508 0.0029

CYS 1508 THR 1509 0.0058

THR 1509 ARG 1510 0.0032

ARG 1510 ALA 1511 0.0071

ALA 1511 VAL 1512 -0.0000

VAL 1512 LEU 1513 0.0073

LEU 1513 ASP 1514 0.0043

ASP 1514 ALA 1515 0.0043

ALA 1515 LEU 1516 0.0026

LEU 1516 SER 1517 0.0404

SER 1517 ASN 1518 0.0074

ASN 1518 GLN 1519 0.0033

GLN 1519 GLY 1520 0.0078

GLY 1520 ILE 1521 0.0009

ILE 1521 ALA 1522 0.0069

ALA 1522 ARG 1523 0.0023

ARG 1523 CYS 1524 0.0074

CYS 1524 ALA 1525 0.0065

ALA 1525 GLN 1526 0.0046

GLN 1526 TYR 1527 0.0039

TYR 1527 ASP 1528 0.0076

ASP 1528 PHE 1529 0.0010

PHE 1529 THR 1530 0.0079

THR 1530 ASP 1531 0.0045

ASP 1531 VAL 1532 0.0079

VAL 1532 SER 1533 -0.0406

SER 1533 SER 1534 0.0059

SER 1534 GLY 1535 0.0002

GLY 1535 PHE 1536 0.0055

PHE 1536 PHE 1537 0.0034

PHE 1537 GLU 1538 0.0037

GLU 1538 ALA 1539 0.0027

ALA 1539 ALA 1540 0.0033

ALA 1540 GLN 1541 0.0047

GLN 1541 GLN 1542 0.0009

GLN 1542 LYS 1543 0.0054

LYS 1543 PHE 1544 0.0016

PHE 1544 ALA 1545 0.0056

ALA 1545 ALA 1546 0.0058

ALA 1546 PHE 1547 0.0015

PHE 1547 ASP 1548 0.0048

ASP 1548 ASP 1549 0.1170

ASP 1549 VAL 1550 0.0055

VAL 1550 ILE 1551 0.0063

ILE 1551 ARG 1552 0.0063

ARG 1552 PHE 1553 0.0060

PHE 1553 GLN 1554 0.0048

GLN 1554 LYS 1555 0.0075

LYS 1555 LEU 1556 0.0043

LEU 1556 ASP 1557 0.0072

ASP 1557 ILE 1558 0.0048

ILE 1558 GLU 1559 0.0067

GLU 1559 LYS 1560 0.0061

LYS 1560 ASP 1561 0.0025

ASP 1561 ILE 1562 0.0071

ILE 1562 GLU 1563 0.0050

GLU 1563 MET 1564 0.0062

MET 1564 GLN 1565 -0.0303

GLN 1565 GLY 1566 0.0054

GLY 1566 PHE 1567 0.0055

PHE 1567 GLU 1568 0.0039

GLU 1568 CYS 1569 0.0061

CYS 1569 GLY 1570 0.0063

GLY 1570 SER 1571 0.0058

SER 1571 TYR 1572 0.0003

TYR 1572 ASP 1573 0.0051

ASP 1573 LEU 1574 0.0015

LEU 1574 VAL 1575 0.0058

VAL 1575 ILE 1576 0.0006

ILE 1576 ALA 1577 0.0054

ALA 1577 SER 1578 0.0003

SER 1578 GLN 1579 0.0054

GLN 1579 VAL 1580 0.0017

VAL 1580 LEU 1581 0.0759

LEU 1581 HIS 1582 0.0093

HIS 1582 ALA 1583 0.0111

ALA 1583 THR 1584 0.0014

THR 1584 GLY 1585 0.0090

GLY 1585 LYS 1586 0.0111

LYS 1586 MET 1587 0.0099

MET 1587 GLU 1588 0.0053

GLU 1588 HIS 1589 0.0081

HIS 1589 THR 1590 0.0065

THR 1590 MET 1591 0.0121

MET 1591 ALA 1592 0.0005

ALA 1592 ASN 1593 0.0124

ASN 1593 VAL 1594 0.0043

VAL 1594 ARG 1595 0.0100

ARG 1595 LYS 1596 0.0048

LYS 1596 LEU 1597 -0.0606

LEU 1597 LEU 1598 0.0107

LEU 1598 LYS 1599 0.0068

LYS 1599 PRO 1600 0.0109

PRO 1600 GLY 1601 0.0029

GLY 1601 GLY 1602 0.0089

GLY 1602 LYS 1603 0.0006

LYS 1603 LEU 1604 0.0088

LEU 1604 LEU 1605 0.0009

LEU 1605 LEU 1606 0.0085

LEU 1606 VAL 1607 0.0016

VAL 1607 GLU 1608 0.0109

GLU 1608 THR 1609 0.0052

THR 1609 THR 1610 0.0109

THR 1610 ARG 1611 0.0031

ARG 1611 ASP 1612 0.0099

ASP 1612 GLU 1613 -0.0853

GLU 1613 MET 1614 0.0294

MET 1614 ASP 1615 0.0336

ASP 1615 LEU 1616 0.0031

LEU 1616 GLN 1617 0.0304

GLN 1617 LEU 1618 0.0221

LEU 1618 VAL 1619 0.0314

VAL 1619 PHE 1620 0.0012

PHE 1620 GLY 1621 0.0336

GLY 1621 LEU 1622 0.0339

LEU 1622 LEU 1623 0.0080

LEU 1623 PRO 1624 0.0092

PRO 1624 GLY 1625 0.0305

GLY 1625 TRP 1626 0.0174

TRP 1626 TRP 1627 0.0288

TRP 1627 LEU 1628 0.0014

LEU 1628 SER 1629 -0.0431

SER 1629 SER 1630 0.0189

SER 1630 GLU 1631 0.0226

GLU 1631 GLU 1632 0.0151

GLU 1632 GLU 1633 0.0151

GLU 1633 ARG 1634 0.0259

ARG 1634 GLN 1635 0.0257

GLN 1635 MET 1636 0.0006

MET 1636 SER 1637 0.0259

SER 1637 PRO 1638 0.0128

PRO 1638 SER 1639 0.0227

SER 1639 LEU 1640 0.0242

LEU 1640 SER 1641 0.0164

SER 1641 THR 1642 0.0251

THR 1642 ASN 1643 0.0238

ASN 1643 SER 1644 0.0148

SER 1644 TRP 1645 -0.0305

TRP 1645 GLU 1646 0.0150

GLU 1646 LYS 1647 0.0110

LYS 1647 VAL 1648 0.0148

VAL 1648 LEU 1649 0.0160

LEU 1649 LYS 1650 0.0123

LYS 1650 LYS 1651 0.0121

LYS 1651 THR 1652 0.0160

THR 1652 GLY 1653 0.0143

GLY 1653 PHE 1654 0.0058

PHE 1654 ASP 1655 0.0158

ASP 1655 GLY 1656 0.0032

GLY 1656 LEU 1657 0.0036

LEU 1657 ASP 1658 0.0168

ASP 1658 ILE 1659 0.0020

ILE 1659 GLU 1660 0.0076

GLU 1660 LEU 1661 0.0120

LEU 1661 ARG 1662 0.0075

ARG 1662 ASP 1663 0.0113

ASP 1663 CYS 1664 0.0078

CYS 1664 ASP 1665 0.0172

ASP 1665 SER 1666 0.0143

SER 1666 ASP 1667 0.0145

ASP 1667 GLU 1668 0.0107

GLU 1668 PHE 1669 0.0176

PHE 1669 TYR 1670 0.0028

TYR 1670 SER 1671 0.0111

SER 1671 PHE 1672 0.0080

PHE 1672 SER 1673 0.0100

SER 1673 VAL 1674 0.0119

VAL 1674 MET 1675 0.0057

MET 1675 MET 1676 0.0061

MET 1676 ALA 1677 -0.0488

ALA 1677 THR 1678 0.0032

THR 1678 ALA 1679 0.0004

ALA 1679 SER 1680 0.0033

SER 1680 SER 1681 0.0034

SER 1681 THR 1682 0.0030

THR 1682 ILE 1683 0.0018

ILE 1683 ALA 1684 0.0026

ALA 1684 SER 1685 0.0031

SER 1685 SER 1686 0.0031

SER 1686 SER 1687 0.0035

SER 1687 MET 1688 0.0010

MET 1688 ALA 1689 0.0016

ALA 1689 PHE 1690 0.0006

PHE 1690 ALA 1691 0.0006

ALA 1691 ILE 1692 0.0003

ILE 1692 VAL 1693 -0.0557

VAL 1693 TYR 1694 0.0012

TYR 1694 GLY 1695 0.0019

GLY 1695 GLU 1696 0.0024

GLU 1696 VAL 1697 0.0082

VAL 1697 PRO 1698 0.0032

PRO 1698 LEU 1699 0.0058

LEU 1699 PRO 1700 0.0082

PRO 1700 ASP 1701 0.0040

ASP 1701 GLN 1702 0.0069

GLN 1702 PHE 1703 0.0082

PHE 1703 LEU 1704 0.0066

LEU 1704 ASP 1705 0.0046

ASP 1705 ASP 1706 0.0078

ASP 1706 MET 1707 0.0080

MET 1707 LYS 1708 0.0052

LYS 1708 THR 1709 -0.0061

THR 1709 ALA 1710 0.0078

ALA 1710 ILE 1711 0.0075

ILE 1711 SER 1712 0.0043

SER 1712 SER 1713 0.0065

SER 1713 SER 1714 0.0079

SER 1714 ALA 1715 0.0077

ALA 1715 VAL 1716 0.0053

VAL 1716 SER 1717 0.0036

SER 1717 ASP 1718 0.0023

ASP 1718 PRO 1719 0.0029

PRO 1719 VAL 1720 0.0049

VAL 1720 VAL 1721 0.0007

VAL 1721 GLY 1722 0.0038

GLY 1722 HIS 1723 0.0015

HIS 1723 LEU 1724 0.0078

LEU 1724 ASP 1725 -0.0196

ASP 1725 SER 1726 0.0038

SER 1726 ILE 1727 0.0019

ILE 1727 ASP 1728 0.0025

ASP 1728 ALA 1729 0.0062

ALA 1729 THR 1730 0.0033

THR 1730 GLY 1731 0.0017

GLY 1731 LYS 1732 0.0058

LYS 1732 PHE 1733 0.0065

PHE 1733 CYS 1734 0.0003

CYS 1734 ILE 1735 0.0048

ILE 1735 PHE 1736 0.0003

PHE 1736 ILE 1737 0.0040

ILE 1737 GLU 1738 0.0007

GLU 1738 ASP 1739 0.0025

ASP 1739 PRO 1740 0.0055

PRO 1740 GLU 1741 -0.0038

GLU 1741 THR 1742 0.0070

THR 1742 ASP 1743 0.0068

ASP 1743 ILE 1744 0.0063

ILE 1744 LEU 1745 0.0072

LEU 1745 SER 1746 0.0016

SER 1746 SER 1747 0.0054

SER 1747 PRO 1748 0.0043

PRO 1748 ASP 1749 0.0066

ASP 1749 GLU 1750 0.0056

GLU 1750 LYS 1751 0.0058

LYS 1751 SER 1752 0.0068

SER 1752 TYR 1753 0.0067

TYR 1753 ALA 1754 0.0052

ALA 1754 SER 1755 0.0063

SER 1755 ILE 1756 0.0070

ILE 1756 GLN 1757 0.0199

GLN 1757 LYS 1758 0.0050

LYS 1758 LEU 1759 0.0064

LEU 1759 VAL 1760 0.0059

VAL 1760 THR 1761 0.0055

THR 1761 ARG 1762 0.0054

ARG 1762 CYS 1763 0.0063

CYS 1763 LYS 1764 0.0012

LYS 1764 GLY 1765 0.0058

GLY 1765 LEU 1766 0.0015

LEU 1766 ILE 1767 0.0060

ILE 1767 TRP 1768 0.0003

TRP 1768 VAL 1769 0.0053

VAL 1769 SER 1770 0.0020

SER 1770 ARG 1771 0.0046

ARG 1771 GLY 1772 0.0060

GLY 1772 GLY 1773 0.0155

GLY 1773 ALA 1774 0.0031

ALA 1774 MET 1775 0.0071

MET 1775 HIS 1776 0.0007

HIS 1776 GLY 1777 0.0061

GLY 1777 THR 1778 0.0040

THR 1778 ARG 1779 0.0071

ARG 1779 PRO 1780 0.0072

PRO 1780 ASN 1781 0.0071

ASN 1781 SER 1782 0.0026

SER 1782 SER 1783 0.0055

SER 1783 LEU 1784 0.0071

LEU 1784 LYS 1785 0.0027

LYS 1785 THR 1786 0.0052

THR 1786 GLY 1787 0.0070

GLY 1787 LEU 1788 0.0069

LEU 1788 LEU 1789 0.0014

LEU 1789 ARG 1790 0.0062

ARG 1790 THR 1791 0.0070

THR 1791 LEU 1792 0.0061

LEU 1792 ARG 1793 0.0022

ARG 1793 LEU 1794 0.0071

LEU 1794 GLU 1795 0.0067

GLU 1795 TYR 1796 0.0046

TYR 1796 THR 1797 0.0028

THR 1797 GLU 1798 0.0053

GLU 1798 LYS 1799 0.0032

LYS 1799 ARG 1800 0.0067

ARG 1800 PHE 1801 0.0004

PHE 1801 ILE 1802 0.0064

ILE 1802 SER 1803 0.0014

SER 1803 LEU 1804 0.0068

LEU 1804 ASP 1805 0.0093

ASP 1805 LEU 1806 0.0071

LEU 1806 ASP 1807 0.0052

ASP 1807 SER 1808 0.0001

SER 1808 ALA 1809 0.0068

ALA 1809 ARG 1810 0.0054

ARG 1810 PRO 1811 0.0063

PRO 1811 GLN 1812 0.0070

GLN 1812 TRP 1813 0.0043

TRP 1813 ASN 1814 0.0048

ASN 1814 HIS 1815 0.0004

HIS 1815 ASP 1816 0.0069

ASP 1816 SER 1817 0.0068

SER 1817 ILE 1818 0.0042

ILE 1818 THR 1819 0.0035

THR 1819 THR 1820 0.0066

THR 1820 ILE 1821 0.0249

ILE 1821 ASN 1822 0.0007

ASN 1822 GLU 1823 0.0022

GLU 1823 VAL 1824 0.0025

VAL 1824 LEU 1825 0.0028

LEU 1825 CYS 1826 0.0004

CYS 1826 GLY 1827 0.0029

GLY 1827 ALA 1828 0.0026

ALA 1828 LEU 1829 0.0016

LEU 1829 ALA 1830 0.0010

ALA 1830 GLN 1831 0.0030

GLN 1831 ASN 1832 0.0010

ASN 1832 ALA 1833 0.0028

ALA 1833 ASP 1834 0.0026

ASP 1834 SER 1835 0.0013

SER 1835 SER 1836 0.0024

SER 1836 ILE 1837 -0.0264

ILE 1837 LYS 1838 0.0022

LYS 1838 ASP 1839 0.0012

ASP 1839 SER 1840 0.0023

SER 1840 GLU 1841 0.0028

GLU 1841 PHE 1842 0.0051

PHE 1842 ALA 1843 0.0025

ALA 1843 GLU 1844 0.0053

GLU 1844 GLN 1845 0.0052

GLN 1845 ASP 1846 0.0057

ASP 1846 GLY 1847 0.0044

GLY 1847 GLN 1848 0.0017

GLN 1848 LEU 1849 0.0051

LEU 1849 PHE 1850 0.0057

PHE 1850 VAL 1851 0.0042

VAL 1851 PRO 1852 0.0058

PRO 1852 ARG 1853 -0.0400

ARG 1853 ILE 1854 0.0266

ILE 1854 SER 1855 0.0359

SER 1855 CYS 1856 0.0277

CYS 1856 ASP 1857 0.0058

ASP 1857 ILE 1858 0.0357

ILE 1858 ALA 1859 0.0085

ALA 1859 ARG 1860 0.0270

ARG 1860 ASN 1861 0.0258

ASN 1861 GLU 1862 0.0354

GLU 1862 ASP 1863 0.0020

ASP 1863 LEU 1864 0.0362

LEU 1864 SER 1865 0.0270

SER 1865 SER 1866 0.0254

SER 1866 ASP 1867 0.0241

ASP 1867 SER 1868 0.0152

SER 1868 ASN 1869 0.0389

ASN 1869 SER 1870 0.1465

SER 1870 PRO 1871 0.0883

PRO 1871 ALA 1872 0.1068

ALA 1872 GLN 1873 0.1438

GLN 1873 MET 1874 0.0771

MET 1874 GLU 1875 0.1416

GLU 1875 PRO 1876 0.1126

PRO 1876 PHE 1877 0.1133

PHE 1877 HIS 1878 0.1440

HIS 1878 GLN 1879 0.0069

GLN 1879 PRO 1880 0.1279

PRO 1880 GLY 1881 0.1165

GLY 1881 LYS 1882 0.1438

LYS 1882 LEU 1883 0.0886

LEU 1883 LEU 1884 0.1174

LEU 1884 GLN 1885 0.1372

GLN 1885 MET 1886 0.0912

MET 1886 GLY 1887 0.1268

GLY 1887 ILE 1888 0.1239

ILE 1888 LYS 1889 0.0572

LYS 1889 THR 1890 0.0951

THR 1890 PRO 1891 0.0403

PRO 1891 GLY 1892 0.0740

GLY 1892 LEU 1893 0.1141

LEU 1893 ILE 1894 0.1080

ILE 1894 ASP 1895 0.0872

ASP 1895 THR 1896 0.0600

THR 1896 LEU 1897 0.1167

LEU 1897 GLN 1898 0.0488

GLN 1898 PHE 1899 0.1105

PHE 1899 SER 1900 0.0403

SER 1900 LYS 1901 0.1197

LYS 1901 THR 1902 0.1499

THR 1902 ASP 1903 0.1038

ASP 1903 ALA 1904 0.1280

ALA 1904 THR 1905 0.1465

THR 1905 ASP 1906 0.1494

ASP 1906 ASN 1907 0.1277

ASN 1907 LEU 1908 0.0010

LEU 1908 PRO 1909 0.1343

PRO 1909 ASN 1910 0.1260

ASN 1910 ASP 1911 0.0206

ASP 1911 TYR 1912 0.1491

TYR 1912 ILE 1913 0.1424

ILE 1913 GLU 1914 0.1270

GLU 1914 ILE 1915 0.0955

ILE 1915 GLU 1916 0.1444

GLU 1916 PRO 1917 0.0112

PRO 1917 LYS 1918 0.1029

LYS 1918 ALA 1919 0.0915

ALA 1919 PHE 1920 0.1357

PHE 1920 GLY 1921 0.0640

GLY 1921 LEU 1922 0.1332

LEU 1922 ASN 1923 0.1221

ASN 1923 PHE 1924 0.1297

PHE 1924 ARG 1925 0.0776

ARG 1925 ASP 1926 0.0698

ASP 1926 VAL 1927 0.1289

VAL 1927 MET 1928 0.1357

MET 1928 VAL 1929 0.0246

VAL 1929 ALA 1930 0.1237

ALA 1930 MET 1931 0.1186

MET 1931 GLY 1932 0.1127

GLY 1932 GLN 1933 -0.0943

GLN 1933 LEU 1934 0.1318

LEU 1934 GLU 1935 0.0712

GLU 1935 GLU 1936 0.1278

GLU 1936 SER 1937 0.0937

SER 1937 ILE 1938 0.1198

ILE 1938 MET 1939 0.1112

MET 1939 GLY 1940 0.1174

GLY 1940 PHE 1941 0.0785

PHE 1941 GLU 1942 0.1181

GLU 1942 CYS 1943 0.1255

CYS 1943 ALA 1944 0.1254

ALA 1944 GLY 1945 0.0689

GLY 1945 VAL 1946 0.1099

VAL 1946 VAL 1947 0.1118

VAL 1947 ARG 1948 0.0059

ARG 1948 ARG 1949 0.1070

ARG 1949 VAL 1950 0.1240

VAL 1950 GLY 1951 0.1269

GLY 1951 PRO 1952 0.1456

PRO 1952 SER 1953 0.0642

SER 1953 SER 1954 0.1022

SER 1954 ALA 1955 0.1463

ALA 1955 GLY 1956 0.1019

GLY 1956 HIS 1957 0.0634

HIS 1957 ASN 1958 0.1402

ASN 1958 ILE 1959 0.1084

ILE 1959 LYS 1960 0.0888

LYS 1960 VAL 1961 0.0891

VAL 1961 GLY 1962 0.1154

GLY 1962 ASP 1963 0.0370

ASP 1963 ARG 1964 0.1066

ARG 1964 VAL 1965 0.2336

VAL 1965 CYS 1966 0.1240

CYS 1966 ALA 1967 0.1176

ALA 1967 LEU 1968 0.1355

LEU 1968 LEU 1969 0.0336

LEU 1969 GLY 1970 0.1063

GLY 1970 GLY 1971 0.1359

GLY 1971 GLN 1972 0.0841

GLN 1972 TRP 1973 0.1356

TRP 1973 THR 1974 0.0735

THR 1974 ASN 1975 0.1313

ASN 1975 THR 1976 0.1352

THR 1976 VAL 1977 0.0949

VAL 1977 ARG 1978 0.1334

ARG 1978 VAL 1979 0.0588

VAL 1979 HIS 1980 0.1281

HIS 1980 TRP 1981 0.0678

TRP 1981 HIS 1982 0.0548

HIS 1982 SER 1983 0.1357

SER 1983 VAL 1984 0.1386

VAL 1984 ALA 1985 0.0633

ALA 1985 PRO 1986 0.1385

PRO 1986 ILE 1987 0.0999

ILE 1987 PRO 1988 0.0906

PRO 1988 GLN 1989 0.1160

GLN 1989 ALA 1990 0.0732

ALA 1990 MET 1991 0.1367

MET 1991 ASP 1992 0.1039

ASP 1992 TRP 1993 0.0714

TRP 1993 GLU 1994 0.1062

GLU 1994 THR 1995 0.0554

THR 1995 ALA 1996 0.0915

ALA 1996 ALA 1997 0.1436

ALA 1997 SER 1998 0.0400

SER 1998 ILE 1999 0.1075

ILE 1999 PRO 2000 0.0617

PRO 2000 ILE 2001 0.1130

ILE 2001 VAL 2002 0.0121

VAL 2002 PHE 2003 0.0951

PHE 2003 VAL 2004 0.0680

VAL 2004 THR 2005 0.1104

THR 2005 ALA 2006 0.0029

ALA 2006 TYR 2007 0.1128

TYR 2007 ILE 2008 0.0767

ILE 2008 SER 2009 0.0826

SER 2009 LEU 2010 0.0169

LEU 2010 VAL 2011 0.1123

VAL 2011 LYS 2012 0.0488

LYS 2012 ILE 2013 0.3697

ILE 2013 ALA 2014 0.0053

ALA 2014 ARG 2015 0.0518

ARG 2015 MET 2016 0.0146

MET 2016 GLN 2017 0.0230

GLN 2017 ALA 2018 0.0162

ALA 2018 GLY 2019 0.0301

GLY 2019 GLU 2020 0.0331

GLU 2020 THR 2021 0.0561

THR 2021 VAL 2022 0.0226

VAL 2022 LEU 2023 0.0537

LEU 2023 ILE 2024 0.0357

ILE 2024 HIS 2025 0.0467

HIS 2025 ALA 2026 0.0529

ALA 2026 ALA 2027 0.0380

ALA 2027 SER 2028 0.0561

SER 2028 GLY 2029 -0.0478

GLY 2029 GLY 2030 0.0775

GLY 2030 VAL 2031 0.0910

VAL 2031 GLY 2032 0.0180

GLY 2032 GLN 2033 0.0778

GLN 2033 ALA 2034 0.0737

ALA 2034 ALA 2035 0.0801

ALA 2035 ILE 2036 0.0157

ILE 2036 ILE 2037 0.0905

ILE 2037 LEU 2038 0.0831

LEU 2038 ALA 2039 0.0501

ALA 2039 LYS 2040 0.0462

LYS 2040 HIS 2041 0.0783

HIS 2041 VAL 2042 0.0909

VAL 2042 GLY 2043 0.0125

GLY 2043 ALA 2044 0.0883

ALA 2044 GLU 2045 0.0204

GLU 2045 ILE 2046 0.0562

ILE 2046 PHE 2047 0.0763

PHE 2047 ALA 2048 0.0497

ALA 2048 THR 2049 0.0638

THR 2049 VAL 2050 0.0719

VAL 2050 GLY 2051 0.0665

GLY 2051 THR 2052 0.0524

THR 2052 ASP 2053 0.0161

ASP 2053 GLU 2054 0.0657

GLU 2054 LYS 2055 0.0639

LYS 2055 ARG 2056 0.0178

ARG 2056 ASP 2057 0.0627

ASP 2057 LEU 2058 0.0436

LEU 2058 LEU 2059 0.0738

LEU 2059 ILE 2060 0.0026

ILE 2060 LYS 2061 0.1172

LYS 2061 GLU 2062 0.0366

GLU 2062 TYR 2063 0.0694

TYR 2063 LYS 2064 0.0053

LYS 2064 ILE 2065 0.0659

ILE 2065 PRO 2066 0.0276

PRO 2066 ASP 2067 0.0684

ASP 2067 ASP 2068 0.0671

ASP 2068 HIS 2069 0.0281

HIS 2069 ILE 2070 0.0403

ILE 2070 PHE 2071 0.0572

PHE 2071 SER 2072 0.0362

SER 2072 SER 2073 0.0098

SER 2073 ARG 2074 0.0653

ARG 2074 ASN 2075 0.0516

ASN 2075 ALA 2076 0.0668

ALA 2076 LEU 2077 0.0771

LEU 2077 PHE 2078 0.0314

PHE 2078 ALA 2079 0.0318

ALA 2079 LYS 2080 0.0051

LYS 2080 SER 2081 0.0265

SER 2081 ILE 2082 0.0256

ILE 2082 ARG 2083 0.0296

ARG 2083 GLN 2084 0.0034

GLN 2084 ARG 2085 0.0321

ARG 2085 THR 2086 0.0269

THR 2086 ASN 2087 0.0156

ASN 2087 GLY 2088 0.0180

GLY 2088 LYS 2089 0.0200

LYS 2089 GLY 2090 0.0166

GLY 2090 VAL 2091 0.0204

VAL 2091 ASP 2092 0.0240

ASP 2092 VAL 2093 -0.0473

VAL 2093 VAL 2094 0.0093

VAL 2094 LEU 2095 0.0034

LEU 2095 ASN 2096 0.0123

ASN 2096 CYS 2097 0.0036

CYS 2097 LEU 2098 0.0148

LEU 2098 ALA 2099 0.0128

ALA 2099 GLY 2100 0.0141

GLY 2100 GLY 2101 0.0021

GLY 2101 LEU 2102 0.0149

LEU 2102 LEU 2103 0.0152

LEU 2103 GLN 2104 0.0093

GLN 2104 GLU 2105 0.0080

GLU 2105 SER 2106 0.0155

SER 2106 PHE 2107 0.0157

PHE 2107 ASP 2108 0.0048

ASP 2108 CYS 2109 0.0479

CYS 2109 LEU 2110 0.0180

LEU 2110 ALA 2111 0.0089

ALA 2111 ASP 2112 0.0188

ASP 2112 PHE 2113 0.0110

PHE 2113 GLY 2114 0.0166

GLY 2114 ARG 2115 0.0031

ARG 2115 PHE 2116 0.0124

PHE 2116 ILE 2117 0.0084

ILE 2117 GLU 2118 0.0091

GLU 2118 ILE 2119 0.0125

ILE 2119 GLY 2120 0.0164

GLY 2120 LYS 2121 0.0033

LYS 2121 ARG 2122 0.0187

ARG 2122 ASP 2123 0.0146

ASP 2123 ILE 2124 0.0151

ILE 2124 GLU 2125 0.1041

GLU 2125 LEU 2126 0.0006

LEU 2126 ASN 2127 0.0041

ASN 2127 HIS 2128 0.0022

HIS 2128 CYS 2129 0.0046

CYS 2129 LEU 2130 0.0037

LEU 2130 ASN 2131 0.0039

ASN 2131 MET 2132 0.0022

MET 2132 GLY 2133 0.0037

GLY 2133 MET 2134 0.0031

MET 2134 PHE 2135 0.0010

PHE 2135 ALA 2136 0.0042

ALA 2136 ARG 2137 0.0044

ARG 2137 SER 2138 0.0006

SER 2138 ALA 2139 0.0040

ALA 2139 THR 2140 0.0028

THR 2140 PHE 2141 -0.1158

PHE 2141 THR 2142 0.0229

THR 2142 ALA 2143 0.0432

ALA 2143 VAL 2144 0.0703

VAL 2144 ASP 2145 0.0126

ASP 2145 LEU 2146 0.0739

LEU 2146 ILE 2147 0.0182

ILE 2147 ALA 2148 0.0910

ALA 2148 ILE 2149 0.0804

ILE 2149 GLY 2150 0.0409

GLY 2150 ARG 2151 0.0534

ARG 2151 ASP 2152 0.0785

ASP 2152 ARG 2153 0.0566

ARG 2153 SER 2154 0.0804

SER 2154 TYR 2155 0.0785

TYR 2155 MET 2156 0.0230

MET 2156 PHE 2157 0.2561

PHE 2157 ALA 2158 0.1226

ALA 2158 GLU 2159 0.0203

GLU 2159 ALA 2160 0.0981

ALA 2160 LEU 2161 0.1106

LEU 2161 PRO 2162 0.1278

PRO 2162 LYS 2163 0.0178

LYS 2163 ILE 2164 0.1213

ILE 2164 MET 2165 0.1104

MET 2165 THR 2166 0.0965

THR 2166 LEU 2167 0.0412

LEU 2167 LEU 2168 0.1235

LEU 2168 GLN 2169 0.1230

GLN 2169 GLU 2170 0.0384

GLU 2170 LYS 2171 0.1049

LYS 2171 ALA 2172 0.1121

ALA 2172 ILE 2173 0.0402

ILE 2173 ARG 2174 0.1283

ARG 2174 PRO 2175 0.0610

PRO 2175 VAL 2176 0.1356

VAL 2176 THR 2177 0.1249

THR 2177 PRO 2178 0.1213

PRO 2178 ILE 2179 0.0110

ILE 2179 SER 2180 0.1100

SER 2180 ILE 2181 0.0520

ILE 2181 TYR 2182 0.0536

TYR 2182 LYS 2183 0.0311

LYS 2183 ILE 2184 0.0563

ILE 2184 GLY 2185 0.1216

GLY 2185 ASP 2186 0.0505

ASP 2186 ILE 2187 0.1351

ILE 2187 GLU 2188 0.1361

GLU 2188 THR 2189 -0.0406

THR 2189 ALA 2190 0.1278

ALA 2190 PHE 2191 0.1228

PHE 2191 ARG 2192 0.1155

ARG 2192 LEU 2193 0.0362

LEU 2193 MET 2194 0.1387

MET 2194 GLN 2195 0.1301

GLN 2195 ALA 2196 0.0552

ALA 2196 GLY 2197 0.1006

GLY 2197 LYS 2198 0.1098

LYS 2198 HIS 2199 0.1358

HIS 2199 MET 2200 0.0825

MET 2200 GLY 2201 0.1303

GLY 2201 LYS 2202 0.0079

LYS 2202 ILE 2203 0.0651

ILE 2203 VAL 2204 0.0900

VAL 2204 ILE 2205 -0.0210

ILE 2205 THR 2206 0.1240

THR 2206 ALA 2207 0.0016

ALA 2207 PRO 2208 0.1456

PRO 2208 GLU 2209 0.0169

GLU 2209 ASP 2210 0.1501

ASP 2210 ALA 2211 0.1352

ALA 2211 MET 2212 0.1096

MET 2212 VAL 2213 0.1510

VAL 2213 PRO 2214 0.1248

PRO 2214 VAL 2215 0.0692

VAL 2215 ILE 2216 0.1010

ILE 2216 THR 2217 0.0302

THR 2217 ARG 2218 0.1436

ARG 2218 PRO 2219 0.0038

PRO 2219 PRO 2220 0.1335

PRO 2220 LYS 2221 0.4581

LYS 2221 LEU 2222 0.0086

LEU 2222 GLN 2223 0.0027

GLN 2223 LEU 2224 0.0087

LEU 2224 ARG 2225 0.0047

ARG 2225 PRO 2226 0.0069

PRO 2226 ASP 2227 0.0088

ASP 2227 ALA 2228 0.0008

ALA 2228 SER 2229 0.0036

SER 2229 TYR 2230 0.0023

TYR 2230 LEU 2231 0.0030

LEU 2231 ILE 2232 0.0042

ILE 2232 VAL 2233 0.0024

VAL 2233 GLY 2234 0.0074

GLY 2234 GLY 2235 0.0023

GLY 2235 LEU 2236 0.0086

LEU 2236 GLY 2237 -0.0711

GLY 2237 GLY 2238 0.0239

GLY 2238 ILE 2239 0.0193

ILE 2239 GLY 2240 0.0173

GLY 2240 ARG 2241 0.0208

ARG 2241 SER 2242 0.0225

SER 2242 LEU 2243 0.0184

LEU 2243 CYS 2244 0.0184

CYS 2244 LYS 2245 0.0216

LYS 2245 ASN 2246 0.0223

ASN 2246 PHE 2247 0.0186

PHE 2247 VAL 2248 0.0174

VAL 2248 GLU 2249 0.0229

GLU 2249 ASN 2250 0.0220

ASN 2250 GLY 2251 0.0147

GLY 2251 ALA 2252 0.0170

ALA 2252 ARG 2253 0.0420

ARG 2253 SER 2254 0.0144

SER 2254 LEU 2255 0.0003

LEU 2255 VAL 2256 0.0125

VAL 2256 LEU 2257 0.0021

LEU 2257 LEU 2258 0.0111

LEU 2258 SER 2259 0.0038

SER 2259 ARG 2260 0.0093

ARG 2260 ASN 2261 0.0214

ASN 2261 ALA 2262 0.0020

ALA 2262 ASN 2263 0.0199

ASN 2263 VAL 2264 0.0181

VAL 2264 SER 2265 0.0039

SER 2265 GLN 2266 0.0166

GLN 2266 GLN 2267 0.0183

GLN 2267 SER 2268 0.0075

SER 2268 GLY 2269 0.1310

GLY 2269 GLU 2270 0.0355

GLU 2270 PHE 2271 0.0342

PHE 2271 LEU 2272 0.0276

LEU 2272 ASP 2273 0.0322

ASP 2273 GLU 2274 0.0364

GLU 2274 LEU 2275 0.0286

LEU 2275 ARG 2276 0.0297

ARG 2276 SER 2277 0.0350

SER 2277 THR 2278 0.0262

THR 2278 GLY 2279 0.0285

GLY 2279 CYS 2280 0.0303

CYS 2280 ILE 2281 0.0361

ILE 2281 VAL 2282 0.0026

VAL 2282 GLY 2283 0.0337

GLY 2283 VAL 2284 0.0001

VAL 2284 VAL 2285 -0.0523

VAL 2285 ASP 2286 0.0030

ASP 2286 CYS 2287 0.0100

CYS 2287 ASP 2288 0.0025

ASP 2288 ILE 2289 0.0098

ILE 2289 SER 2290 0.0045

SER 2290 SER 2291 0.0083

SER 2291 LYS 2292 0.0053

LYS 2292 THR 2293 0.0084

THR 2293 GLN 2294 0.0107

GLN 2294 VAL 2295 0.0094

VAL 2295 GLU 2296 0.0052

GLU 2296 ALA 2297 0.0100

ALA 2297 THR 2298 0.0106

THR 2298 MET 2299 0.0071

MET 2299 LEU 2300 0.0063

LEU 2300 ARG 2301 -0.0211

ARG 2301 LEU 2302 0.0128

LEU 2302 LYS 2303 0.0064

LYS 2303 LYS 2304 0.0091

LYS 2304 ASP 2305 0.0124

ASP 2305 MET 2306 0.0127

MET 2306 LEU 2307 0.0109

LEU 2307 PRO 2308 0.0120

PRO 2308 ILE 2309 0.0011

ILE 2309 ARG 2310 0.0130

ARG 2310 GLY 2311 0.0015

GLY 2311 ILE 2312 0.0024

ILE 2312 VAL 2313 0.0039

VAL 2313 HIS 2314 0.0049

HIS 2314 ALA 2315 0.0077

ALA 2315 GLY 2316 0.0110

GLY 2316 MET 2317 0.1008

MET 2317 VAL 2318 0.0069

VAL 2318 LEU 2319 0.0005

LEU 2319 GLN 2320 0.0071

GLN 2320 ASP 2321 0.0004

ASP 2321 SER 2322 0.0062

SER 2322 VAL 2323 0.0038

VAL 2323 PHE 2324 0.0058

PHE 2324 GLU 2325 0.0066

GLU 2325 ARG 2326 0.0064

ARG 2326 MET 2327 0.0025

MET 2327 SER 2328 0.0026

SER 2328 LEU 2329 0.0029

LEU 2329 ASP 2330 0.0059

ASP 2330 ASP 2331 0.0038

ASP 2331 TYR 2332 0.0077

TYR 2332 ASN 2333 -0.0134

ASN 2333 THR 2334 0.0079

THR 2334 ALA 2335 0.0072

ALA 2335 ILE 2336 0.0072

ILE 2336 ARG 2337 0.0009

ARG 2337 PRO 2338 0.0074

PRO 2338 LYS 2339 0.0069

LYS 2339 VAL 2340 0.0080

VAL 2340 GLN 2341 0.0029

GLN 2341 GLY 2342 0.0069

GLY 2342 SER 2343 0.0082

SER 2343 TRP 2344 0.0069

TRP 2344 ASN 2345 0.0038

ASN 2345 LEU 2346 0.0078

LEU 2346 HIS 2347 0.0082

HIS 2347 SER 2348 0.0050

SER 2348 GLY 2349 -0.0392

GLY 2349 LEU 2350 0.0089

LEU 2350 SER 2351 0.0091

SER 2351 ASP 2352 0.0007

ASP 2352 CYS 2353 0.0091

CYS 2353 ASP 2354 0.0090

ASP 2354 LEU 2355 0.0033

LEU 2355 ASP 2356 0.0085

ASP 2356 PHE 2357 0.0014

PHE 2357 PHE 2358 0.0065

PHE 2358 ILE 2359 0.0025

ILE 2359 MET 2360 0.0044

MET 2360 LEU 2361 0.0046

LEU 2361 SER 2362 0.0041

SER 2362 SER 2363 0.0011

SER 2363 LEU 2364 0.0031

LEU 2364 ALA 2365 -0.0001

ALA 2365 GLY 2366 0.0063

GLY 2366 VAL 2367 0.0046

VAL 2367 SER 2368 0.0026

SER 2368 GLY 2369 0.0079

GLY 2369 SER 2370 0.0083

SER 2370 ALA 2371 0.0072

ALA 2371 SER 2372 0.0042

SER 2372 GLN 2373 0.0038

GLN 2373 ALA 2374 0.0082

ALA 2374 ASN 2375 0.0002

ASN 2375 TYR 2376 0.0083

TYR 2376 THR 2377 0.0055

THR 2377 ALA 2378 0.0055

ALA 2378 GLY 2379 0.0029

GLY 2379 GLY 2380 0.0070

GLY 2380 ALA 2381 -0.0068

ALA 2381 TYR 2382 0.0014

TYR 2382 GLN 2383 0.0057

GLN 2383 ASP 2384 0.0052

ASP 2384 ALA 2385 0.0072

ALA 2385 LEU 2386 0.0007

LEU 2386 ALA 2387 0.0076

ALA 2387 LYS 2388 0.0066

LYS 2388 TYR 2389 0.0042

TYR 2389 ARG 2390 0.0030

ARG 2390 ARG 2391 0.0068

ARG 2391 ALA 2392 0.0074

ALA 2392 GLN 2393 0.0007

GLN 2393 GLY 2394 0.0072

GLY 2394 LEU 2395 0.0073

LEU 2395 SER 2396 0.0066

SER 2396 ALA 2397 0.0496

ALA 2397 VAL 2398 0.0043

VAL 2398 SER 2399 0.0033

SER 2399 ILE 2400 0.0104

ILE 2400 ASP 2401 0.0020

ASP 2401 LEU 2402 0.0158

LEU 2402 GLY 2403 0.0022

GLY 2403 MET 2404 0.0134

MET 2404 VAL 2405 0.0110

VAL 2405 GLN 2406 0.0115

GLN 2406 SER 2407 0.0106

SER 2407 VAL 2408 0.0109

VAL 2408 GLY 2409 0.0166

GLY 2409 TYR 2410 0.0079

TYR 2410 VAL 2411 0.0079

VAL 2411 ALA 2412 0.0159

ALA 2412 GLU 2413 -0.0455

GLU 2413 THR 2414 0.0054

THR 2414 LYS 2415 0.0020

LYS 2415 GLY 2416 0.0067

GLY 2416 VAL 2417 0.0086

VAL 2417 ALA 2418 0.0132

ALA 2418 GLU 2419 0.0002

GLU 2419 ARG 2420 0.0133

ARG 2420 LEU 2421 0.0075

LEU 2421 VAL 2422 0.0106

VAL 2422 ARG 2423 0.0038

ARG 2423 MET 2424 0.0101

MET 2424 GLY 2425 0.0124

GLY 2425 TYR 2426 0.0023

TYR 2426 SER 2427 0.0120

SER 2427 PRO 2428 0.0100

PRO 2428 ILE 2429 0.0523

ILE 2429 SER 2430 0.0029

SER 2430 GLU 2431 0.0039

GLU 2431 MET 2432 0.0069

MET 2432 GLU 2433 0.0053

GLU 2433 VAL 2434 0.0098

VAL 2434 LEU 2435 -0.0000

LEU 2435 LYS 2436 0.0098

LYS 2436 ILE 2437 0.0054

ILE 2437 VAL 2438 0.0068

VAL 2438 GLU 2439 0.0032

GLU 2439 HIS 2440 0.0077

HIS 2440 ALA 2441 0.0088

ALA 2441 ILE 2442 0.0007

ILE 2442 THR 2443 0.0082

THR 2443 ASN 2444 0.0044

ASN 2444 PRO 2445 -0.0333

PRO 2445 PRO 2446 0.0055

PRO 2446 PRO 2447 0.0086

PRO 2447 GLU 2448 0.0085

GLU 2448 ALA 2449 0.0096

ALA 2449 SER 2450 0.0002

SER 2450 SER 2451 0.0098

SER 2451 ALA 2452 0.0056

ALA 2452 GLN 2453 0.0046

GLN 2453 ILE 2454 0.0078

ILE 2454 ILE 2455 0.0027

ILE 2455 THR 2456 0.0089

THR 2456 GLY 2457 0.0051

GLY 2457 ILE 2458 0.0029

ILE 2458 SER 2459 0.0033

SER 2459 THR 2460 0.0077

THR 2460 LYS 2461 -0.0893

LYS 2461 PRO 2462 0.0007

PRO 2462 GLY 2463 0.0064

GLY 2463 ARG 2464 0.0063

ARG 2464 HIS 2465 0.0010

HIS 2465 TRP 2466 0.0072

TRP 2466 THR 2467 0.0032

THR 2467 GLU 2468 0.0067

GLU 2468 SER 2469 0.0002

SER 2469 SER 2470 0.0067

SER 2470 TRP 2471 0.0011

TRP 2471 LEU 2472 0.0063

LEU 2472 GLN 2473 0.0053

GLN 2473 ASP 2474 0.0018

ASP 2474 ALA 2475 0.0067

ALA 2475 ARG 2476 0.0021

ARG 2476 PHE 2477 0.0068

PHE 2477 ALA 2478 0.0041

ALA 2478 THR 2479 0.0058

THR 2479 LEU 2480 0.0051

LEU 2480 ARG 2481 0.0022

ARG 2481 GLU 2482 0.0050

GLU 2482 ARG 2483 0.0059

ARG 2483 ALA 2484 0.0042

ALA 2484 ARG 2485 0.0030

ARG 2485 ASP 2486 0.0057

ASP 2486 VAL 2487 0.0059

VAL 2487 LYS 2488 0.0023

LYS 2488 GLU 2489 0.0049

GLU 2489 LEU 2490 0.0058

LEU 2490 SER 2491 0.0036

SER 2491 ASN 2492 0.0027

ASN 2492 SER 2493 0.0689

SER 2493 GLN 2494 0.0005

GLN 2494 ASN 989 -0.0638

ASN 989 LYS 990 0.1194

LYS 990 ALA 991 0.0332

ALA 991 HIS 992 0.1016

HIS 992 ARG 993 0.0734

ARG 993 GLN 994 0.0667

GLN 994 ARG 995 0.0797

ARG 995 VAL 996 0.1010

VAL 996 HIS 997 0.1024

HIS 997 PRO 998 0.0996

PRO 998 PRO 999 0.1074

PRO 999 HIS 1000 0.0406

HIS 1000 ASP 1001 0.1194

ASP 1001 LEU 1002 0.0200

LEU 1002 LEU 1003 0.1242

LEU 1003 GLY 1004 0.0174

GLY 1004 SER 1005 0.1439

SER 1005 LEU 1006 0.0778

LEU 1006 ILE 1007 0.0955

ILE 1007 VAL 1008 0.0760

VAL 1008 GLY 1009 0.0905

GLY 1009 ARG 1010 0.0069

ARG 1010 ASP 1011 0.0516

ASP 1011 LEU 1012 0.0968

LEU 1012 ARG 1013 0.0069

ARG 1013 GLU 1014 0.0991

GLU 1014 PRO 1015 0.0459

PRO 1015 THR 1016 0.0880

THR 1016 TRP 1017 0.0695

TRP 1017 ARG 1018 0.0659

ARG 1018 HIS 1019 0.0958

HIS 1019 PHE 1020 0.0662

PHE 1020 ILE 1021 -0.2173

ILE 1021 ARG 1022 0.0560

ARG 1022 VAL 1023 0.0519

VAL 1023 GLN 1024 0.0251

GLN 1024 ASP 1025 0.0668

ASP 1025 ILE 1026 0.0008

ILE 1026 PRO 1027 0.0601

PRO 1027 TRP 1028 0.0073

TRP 1028 ILE 1029 0.0653

ILE 1029 ARG 1030 0.0667

ARG 1030 ASP 1031 0.0163

ASP 1031 HIS 1032 0.0545

HIS 1032 VAL 1033 0.0643

VAL 1033 VAL 1034 0.0378

VAL 1034 GLN 1035 0.0648

GLN 1035 SER 1036 0.0249

SER 1036 ALA 1037 -0.1174

ALA 1037 LEU 1038 0.0597

LEU 1038 VAL 1039 0.0484

VAL 1039 TYR 1040 0.0673

TYR 1040 PRO 1041 0.0173

PRO 1041 GLY 1042 0.0462

GLY 1042 ALA 1043 0.0682

ALA 1043 GLY 1044 0.0021

GLY 1044 PHE 1045 0.0683

PHE 1045 ILE 1046 0.0433

ILE 1046 CYS 1047 0.0425

CYS 1047 MET 1048 0.0321

MET 1048 ALA 1049 0.0494

ALA 1049 MET 1050 0.0664

MET 1050 GLU 1051 0.0055

GLU 1051 ALA 1052 0.0645

ALA 1052 MET 1053 -0.1039

MET 1053 VAL 1054 0.0691

VAL 1054 GLN 1055 0.0105

GLN 1055 LEU 1056 0.0730

LEU 1056 HIS 1057 0.0638

HIS 1057 GLU 1058 0.0294

GLU 1058 LEU 1059 0.0546

LEU 1059 ARG 1060 0.0526

ARG 1060 ASP 1061 0.0642

ASP 1061 SER 1062 0.0573

SER 1062 GLN 1063 0.0189

GLN 1063 SER 1064 0.0697

SER 1064 ARG 1065 0.0129

ARG 1065 LYS 1066 0.0683

LYS 1066 VAL 1067 0.0735

VAL 1067 ALA 1068 0.0078

ALA 1068 GLY 1069 0.0226

GLY 1069 TYR 1070 0.0642

TYR 1070 ARG 1071 0.0349

ARG 1071 LEU 1072 0.0652

LEU 1072 ALA 1073 0.0396

ALA 1073 GLU 1074 0.0651

GLU 1074 VAL 1075 0.0381

VAL 1075 ASP 1076 0.0647

ASP 1076 ILE 1077 0.0474

ILE 1077 LEU 1078 0.0624

LEU 1078 ARG 1079 0.0412

ARG 1079 ALA 1080 0.0564

ALA 1080 MET 1081 0.0054

MET 1081 LEU 1082 0.0508

LEU 1082 ILE 1083 0.0273

ILE 1083 PRO 1084 0.0295

PRO 1084 ASP 1085 0.1130

ASP 1085 THR 1086 0.0329

THR 1086 SER 1087 0.0504

SER 1087 GLU 1088 0.0771

GLU 1088 GLY 1089 0.0089

GLY 1089 LEU 1090 0.0386

LEU 1090 GLU 1091 0.0881

GLU 1091 ALA 1092 0.0194

ALA 1092 HIS 1093 0.0773

HIS 1093 ILE 1094 0.0393

ILE 1094 SER 1095 0.0801

SER 1095 LEU 1096 0.0520

LEU 1096 ARG 1097 0.0676

ARG 1097 PRO 1098 0.0540

PRO 1098 CYS 1099 0.0141

CYS 1099 SER 1100 0.0799

SER 1100 THR 1101 0.0610

THR 1101 LYS 1102 0.0475

LYS 1102 LEU 1103 0.0708

LEU 1103 LEU 1104 0.0290

LEU 1104 LEU 1105 0.0562

LEU 1105 THR 1106 0.0738

THR 1106 ASN 1107 0.0157

ASN 1107 GLU 1108 0.0098

GLU 1108 TRP 1109 0.0733

TRP 1109 TYR 1110 0.0239

TYR 1110 ASP 1111 0.0737

ASP 1111 PHE 1112 0.0363

PHE 1112 CYS 1113 0.0565

CYS 1113 VAL 1114 0.0443

VAL 1114 SER 1115 0.0465

SER 1115 SER 1116 0.0193

SER 1116 VAL 1117 -0.0392

VAL 1117 GLY 1118 0.0733

GLY 1118 ASP 1119 0.0199

ASP 1119 ASP 1120 0.0699

ASP 1120 ASP 1121 0.0764

ASP 1121 LYS 1122 0.0018

LYS 1122 PHE 1123 0.0504

PHE 1123 VAL 1124 0.0453

VAL 1124 ASP 1125 0.0325

ASP 1125 HIS 1126 0.0742

HIS 1126 CYS 1127 0.0451

CYS 1127 ARG 1128 0.0548

ARG 1128 GLY 1129 0.0459

GLY 1129 ARG 1130 0.0745

ARG 1130 ILE 1131 0.0703

ILE 1131 THR 1132 0.0759

THR 1132 ILE 1133 0.0565

ILE 1133 GLU 1134 0.0186

GLU 1134 PHE 1135 0.0432

PHE 1135 ASP 1136 0.0339

ASP 1136 THR 1137 0.0361

THR 1137 SER 1138 0.0443

SER 1138 GLY 1139 0.0058

GLY 1139 SER 1140 0.0359

SER 1140 ALA 1141 0.0281

ALA 1141 ASP 1142 0.0463

ASP 1142 THR 1143 0.0357

THR 1143 PRO 1144 0.0387

PRO 1144 ARG 1145 0.0395

ARG 1145 THR 1146 0.0142

THR 1146 SER 1147 0.0463

SER 1147 LEU 1148 0.0464

LEU 1148 ARG 1149 0.3210

ARG 1149 GLU 1150 0.0443

GLU 1150 ARG 1151 0.0426

ARG 1151 SER 1152 0.0268

SER 1152 ARG 1153 0.0162

ARG 1153 SER 1154 0.0428

SER 1154 THR 1155 0.0082

THR 1155 GLY 1156 0.0445

GLY 1156 LEU 1157 0.0427

LEU 1157 MET 1158 0.0190

MET 1158 ARG 1159 0.0444

ARG 1159 SER 1160 0.0372

SER 1160 VAL 1161 0.0265

VAL 1161 ASP 1162 0.0375

ASP 1162 PRO 1163 0.0005

PRO 1163 SER 1164 0.0446

SER 1164 ASN 1165 0.2488

ASN 1165 LEU 1166 0.0338

LEU 1166 TYR 1167 0.0094

TYR 1167 SER 1168 0.0418

SER 1168 PHE 1169 0.0410

PHE 1169 LEU 1170 0.0155

LEU 1170 ARG 1171 0.0307

ARG 1171 ALA 1172 0.0353

ALA 1172 GLN 1173 0.0415

GLN 1173 GLY 1174 0.0043

GLY 1174 ILE 1175 0.0438

ILE 1175 TYR 1176 0.0412

TYR 1176 HIS 1177 0.0434

HIS 1177 GLY 1178 0.0387

GLY 1178 PRO 1179 0.0389

PRO 1179 ILE 1180 0.0346

ILE 1180 PHE 1181 -0.0266

PHE 1181 GLN 1182 0.0131

GLN 1182 ASN 1183 0.0490

ASN 1183 LEU 1184 0.0049

LEU 1184 LYS 1185 0.0302

LYS 1185 THR 1186 0.0109

THR 1186 ILE 1187 0.0462

ILE 1187 SER 1188 0.0114

SER 1188 SER 1189 0.0517

SER 1189 ARG 1190 0.0290

ARG 1190 LYS 1191 0.0530

LYS 1191 ASP 1192 0.0371

ASP 1192 HIS 1193 0.0466

HIS 1193 SER 1194 0.0458

SER 1194 GLU 1195 0.0495

GLU 1195 SER 1196 0.0222

SER 1196 SER 1197 0.1065

SER 1197 PHE 1198 0.0027

PHE 1198 VAL 1199 0.0308

VAL 1199 VAL 1200 0.0139

VAL 1200 ALA 1201 0.0413

ALA 1201 ASN 1202 0.0256

ASN 1202 THR 1203 0.0425

THR 1203 ALA 1204 0.0281

ALA 1204 SER 1205 0.0685

SER 1205 VAL 1206 0.0625

VAL 1206 MET 1207 0.0327

MET 1207 PRO 1208 0.0094

PRO 1208 ASN 1209 0.0682

ASN 1209 GLY 1210 0.0087

GLY 1210 PHE 1211 0.0611

PHE 1211 GLN 1212 0.0492

GLN 1212 SER 1213 0.0539

SER 1213 PRO 1214 0.0327

PRO 1214 HIS 1215 0.0298

HIS 1215 VAL 1216 0.0153

VAL 1216 ILE 1217 0.0508

ILE 1217 HIS 1218 0.0545

HIS 1218 PRO 1219 0.0614

PRO 1219 THR 1220 0.0533

THR 1220 THR 1221 0.0360

THR 1221 LEU 1222 0.0591

LEU 1222 ASP 1223 0.0628

ASP 1223 SER 1224 0.0405

SER 1224 ILE 1225 0.0408

ILE 1225 PHE 1226 0.0628

PHE 1226 GLN 1227 0.0604

GLN 1227 GLY 1228 0.0236

GLY 1228 ALA 1229 0.0905

ALA 1229 TYR 1230 0.0338

TYR 1230 THR 1231 0.0178

THR 1231 ALA 1232 0.0353

ALA 1232 LEU 1233 0.0405

LEU 1233 PRO 1234 0.0095

PRO 1234 GLY 1235 0.0400

GLY 1235 ALA 1236 0.0182

ALA 1236 GLY 1237 0.0253

GLY 1237 LEU 1238 0.0367

LEU 1238 ASP 1239 0.0373

ASP 1239 GLN 1240 0.0089

GLN 1240 ASN 1241 0.0370

ASN 1241 THR 1242 0.0032

THR 1242 ALA 1243 0.0208

ALA 1243 MET 1244 0.0402

MET 1244 ILE 1245 -0.2458

ILE 1245 PRO 1246 0.0567

PRO 1246 ARG 1247 0.0563

ARG 1247 SER 1248 0.0538

SER 1248 ILE 1249 0.0517

ILE 1249 GLN 1250 0.0443

GLN 1250 GLU 1251 0.0551

GLU 1251 LEU 1252 0.0467

LEU 1252 TYR 1253 0.0565

TYR 1253 LEU 1254 0.0421

LEU 1254 SER 1255 0.0565

SER 1255 SER 1256 0.0204

SER 1256 ALA 1257 0.0384

ALA 1257 LEU 1258 0.0559

LEU 1258 THR 1259 0.0374

THR 1259 SER 1260 0.0368

SER 1260 ASP 1261 0.0834

ASP 1261 VAL 1262 0.0455

VAL 1262 GLY 1263 0.0064

GLY 1263 GLN 1264 0.0376

GLN 1264 CYS 1265 0.0184

CYS 1265 LEU 1266 0.0455

LEU 1266 VAL 1267 0.0179

VAL 1267 SER 1268 0.0451

SER 1268 ASP 1269 0.0233

ASP 1269 THR 1270 0.0432

THR 1270 SER 1271 0.0367

SER 1271 LEU 1272 0.0448

LEU 1272 ILE 1273 0.0442

ILE 1273 ARG 1274 0.0434

ARG 1274 TYR 1275 0.0453

TYR 1275 ASP 1276 0.0438

ASP 1276 GLY 1277 0.0627

GLY 1277 GLN 1278 0.0036

GLN 1278 SER 1279 0.0466

SER 1279 PHE 1280 0.0336

PHE 1280 THR 1281 0.0466

THR 1281 VAL 1282 0.0421

VAL 1282 ASN 1283 0.0464

ASN 1283 VAL 1284 0.0446

VAL 1284 ASP 1285 0.0447

ASP 1285 VAL 1286 0.0403

VAL 1286 SER 1287 0.0429

SER 1287 SER 1288 0.0450

SER 1288 LYS 1289 0.0224

LYS 1289 ALA 1290 0.0463

ALA 1290 ASP 1291 0.0446

ASP 1291 SER 1292 0.0025

SER 1292 GLU 1293 0.0288

GLU 1293 HIS 1294 0.0389

HIS 1294 THR 1295 0.0305

THR 1295 PRO 1296 0.0324

PRO 1296 VAL 1297 0.0042

VAL 1297 LEU 1298 0.0453

LEU 1298 GLU 1299 0.0377

GLU 1299 ILE 1300 0.0460

ILE 1300 LYS 1301 0.0392

LYS 1301 GLY 1302 0.0477

GLY 1302 LEU 1303 0.0355

LEU 1303 ARG 1304 0.0471

ARG 1304 ASN 1305 0.0452

ASN 1305 GLN 1306 0.0440

GLN 1306 SER 1307 0.0472

SER 1307 VAL 1308 0.0077

VAL 1308 GLY 1309 -1.2421

GLY 1309 GLN 1310 0.0447

GLN 1310 MET 1311 0.0015

MET 1311 ALA 1312 0.0587

ALA 1312 PRO 1313 0.0524

PRO 1313 GLN 1314 0.0042

GLN 1314 PRO 1315 0.0536

PRO 1315 GLY 1316 0.0594

GLY 1316 ASP 1317 0.0319

ASP 1317 SER 1318 0.0340

SER 1318 SER 1319 0.0549

SER 1319 ASN 1320 0.0519

ASN 1320 ASN 1321 0.0260

ASN 1321 ASP 1322 0.0456

ASP 1322 LEU 1323 0.0589

LEU 1323 CYS 1324 0.0626

CYS 1324 PHE 1325 -0.2406

PHE 1325 LYS 1326 0.0046

LYS 1326 LEU 1327 0.0045

LEU 1327 ASP 1328 0.0035

ASP 1328 TRP 1329 0.0050

TRP 1329 ALA 1330 0.0020

ALA 1330 PRO 1331 0.0041

PRO 1331 ASP 1332 0.0027

ASP 1332 ILE 1333 0.0016

ILE 1333 SER 1334 0.0045

SER 1334 SER 1335 0.0023

SER 1335 VAL 1336 0.0047

VAL 1336 LYS 1337 0.0046

LYS 1337 GLN 1338 0.0032

GLN 1338 GLU 1339 0.0027

GLU 1339 ARG 1340 0.0031

ARG 1340 LEU 1341 -0.1253

LEU 1341 LYS 1342 0.0126

LYS 1342 GLU 1343 0.0049

GLU 1343 LYS 1344 0.0158

LYS 1344 PHE 1345 0.0137

PHE 1345 GLY 1346 0.0147

GLY 1346 PHE 1347 0.0083

PHE 1347 PRO 1348 0.0078

PRO 1348 LEU 1349 0.0156

LEU 1349 ASP 1350 0.0087

ASP 1350 PRO 1351 0.0106

PRO 1351 THR 1352 0.0157

THR 1352 GLU 1353 0.0003

GLU 1353 ALA 1354 0.0156

ALA 1354 ASP 1355 0.0098

ASP 1355 ILE 1356 0.0113

ILE 1356 ILE 1357 0.1009

ILE 1357 MET 1358 0.0306

MET 1358 GLY 1359 0.0343

GLY 1359 LEU 1360 0.0047

LEU 1360 ARG 1361 0.0319

ARG 1361 GLN 1362 0.0220

GLN 1362 ALA 1363 0.0353

ALA 1363 CYS 1364 0.0017

CYS 1364 ILE 1365 0.0364

ILE 1365 HIS 1366 0.0280

HIS 1366 PHE 1367 0.0174

PHE 1367 ILE 1368 0.0194

ILE 1368 HIS 1369 0.0286

HIS 1369 ARG 1370 0.0359

ARG 1370 SER 1371 0.0039

SER 1371 LEU 1372 0.0318

LEU 1372 GLN 1373 0.0299

GLN 1373 SER 1374 0.0356

SER 1374 LEU 1375 0.0016

LEU 1375 THR 1376 0.0298

THR 1376 ALA 1377 0.0098

ALA 1377 PRO 1378 0.0289

PRO 1378 ASP 1379 0.0302

ASP 1379 ARG 1380 0.0344

ARG 1380 ASP 1381 0.0037

ASP 1381 GLN 1382 0.0382

GLN 1382 LEU 1383 0.0341

LEU 1383 ASP 1384 0.0239

ASP 1384 TRP 1385 0.0334

TRP 1385 HIS 1386 0.0194

HIS 1386 GLN 1387 0.0190

GLN 1387 LYS 1388 0.0342

LYS 1388 ARG 1389 0.0004

ARG 1389 PHE 1390 0.0071

PHE 1390 TYR 1391 0.0379

TYR 1391 ASP 1392 0.0361

ASP 1392 TRP 1393 0.0232

TRP 1393 MET 1394 0.0189

MET 1394 VAL 1395 0.0374

VAL 1395 LEU 1396 0.0383

LEU 1396 GLN 1397 0.0100

GLN 1397 ILE 1398 0.0321

ILE 1398 GLN 1399 0.0347

GLN 1399 LEU 1400 0.0328

LEU 1400 ALA 1401 0.0110

ALA 1401 GLU 1402 0.0383

GLU 1402 GLU 1403 0.0376

GLU 1403 ASP 1404 0.0159

ASP 1404 ARG 1405 0.0030

ARG 1405 LEU 1406 0.0353

LEU 1406 ALA 1407 0.0050

ALA 1407 PRO 1408 0.0190

PRO 1408 ASN 1409 0.0338

ASN 1409 SER 1410 0.0191

SER 1410 SER 1411 0.0358

SER 1411 ALA 1412 0.0076

ALA 1412 TRP 1413 0.0310

TRP 1413 LEU 1414 0.0272

LEU 1414 GLN 1415 0.0096

GLN 1415 CYS 1416 0.0284

CYS 1416 SER 1417 0.0251

SER 1417 SER 1418 0.0330

SER 1418 SER 1419 0.0109

SER 1419 ASP 1420 0.0354

ASP 1420 GLU 1421 0.0181

GLU 1421 GLN 1422 0.0341

GLN 1422 LYS 1423 0.0202

LYS 1423 LEU 1424 0.0208

LEU 1424 LEU 1425 0.0182

LEU 1425 GLU 1426 0.0222

GLU 1426 ASN 1427 0.0328

ASN 1427 VAL 1428 0.0044

VAL 1428 ARG 1429 0.0328

ARG 1429 ALA 1430 0.0162

ALA 1430 SER 1431 0.0354

SER 1431 SER 1432 0.0052

SER 1432 VAL 1433 0.0102

VAL 1433 ASN 1434 0.0305

ASN 1434 GLY 1435 0.0200

GLY 1435 GLN 1436 0.0341

GLN 1436 MET 1437 -0.0053

MET 1437 VAL 1438 0.0314

VAL 1438 VAL 1439 0.0192

VAL 1439 HIS 1440 0.0218

HIS 1440 VAL 1441 0.0091

VAL 1441 GLY 1442 0.0260

GLY 1442 LYS 1443 0.0260

LYS 1443 SER 1444 0.0062

SER 1444 MET 1445 0.0240

MET 1445 LEU 1446 0.0311

LEU 1446 ALA 1447 0.0290

ALA 1447 ILE 1448 0.0200

ILE 1448 LEU 1449 0.0274

LEU 1449 ARG 1450 0.0312

ARG 1450 HIS 1451 0.0248

HIS 1451 GLU 1452 0.0157

GLU 1452 ILE 1453 0.1596

ILE 1453 ALA 1454 0.0220

ALA 1454 PRO 1455 0.0244

PRO 1455 LEU 1456 0.0290

LEU 1456 GLU 1457 0.0280

GLU 1457 LEU 1458 0.0079

LEU 1458 MET 1459 0.0308

MET 1459 LEU 1460 0.0299

LEU 1460 GLN 1461 0.0147

GLN 1461 ASP 1462 0.0138

ASP 1462 LYS 1463 0.0221

LYS 1463 LEU 1464 0.0274

LEU 1464 LEU 1465 0.0098

LEU 1465 TYR 1466 0.0306

TYR 1466 ARG 1467 0.0031

ARG 1467 TYR 1468 0.0284

TYR 1468 TYR 1469 0.1356

TYR 1469 THR 1470 0.0073

THR 1470 ASP 1471 0.0022

ASP 1471 ALA 1472 0.0130

ALA 1472 ILE 1473 0.0100

ILE 1473 LYS 1474 0.0109

LYS 1474 TRP 1475 0.0072

TRP 1475 ASP 1476 0.0098

ASP 1476 ARG 1477 0.0130

ARG 1477 SER 1478 0.0005

SER 1478 TYR 1479 0.0126

TYR 1479 GLN 1480 0.0073

GLN 1480 GLN 1481 0.0105

GLN 1481 ILE 1482 0.0030

ILE 1482 ASP 1483 0.0111

ASP 1483 GLN 1484 0.0121

GLN 1484 LEU 1485 0.0761

LEU 1485 VAL 1486 0.0012

VAL 1486 LYS 1487 0.0014

LYS 1487 LEU 1488 0.0000

LEU 1488 HIS 1489 0.0015

HIS 1489 ALA 1490 0.0010

ALA 1490 HIS 1491 0.0011

HIS 1491 LYS 1492 0.0002

LYS 1492 CYS 1493 0.0015

CYS 1493 PRO 1494 0.0004

PRO 1494 THR 1495 0.0016

THR 1495 ALA 1496 0.0018

ALA 1496 LYS 1497 0.0014

LYS 1497 ILE 1498 0.0010

ILE 1498 ILE 1499 0.0014

ILE 1499 GLU 1500 0.0008

GLU 1500 ILE 1501 0.0765

ILE 1501 GLY 1502 0.0051

GLY 1502 ALA 1503 0.0014

ALA 1503 GLY 1504 0.0060

GLY 1504 THR 1505 -0.0001

THR 1505 GLY 1506 0.0068

GLY 1506 GLY 1507 0.0059

GLY 1507 CYS 1508 0.0048

CYS 1508 THR 1509 0.0066

THR 1509 ARG 1510 0.0004

ARG 1510 ALA 1511 0.0068

ALA 1511 VAL 1512 0.0025

VAL 1512 LEU 1513 0.0057

LEU 1513 ASP 1514 0.0020

ASP 1514 ALA 1515 0.0044

ALA 1515 LEU 1516 0.0053

LEU 1516 SER 1517 0.0407

SER 1517 ASN 1518 0.0064

ASN 1518 GLN 1519 0.0006

GLN 1519 GLY 1520 0.0064

GLY 1520 ILE 1521 0.0018

ILE 1521 ALA 1522 0.0039

ALA 1522 ARG 1523 0.0005

ARG 1523 CYS 1524 0.0055

CYS 1524 ALA 1525 0.0062

ALA 1525 GLN 1526 0.0059

GLN 1526 TYR 1527 0.0058

TYR 1527 ASP 1528 0.0064

ASP 1528 PHE 1529 0.0034

PHE 1529 THR 1530 0.0057

THR 1530 ASP 1531 0.0061

ASP 1531 VAL 1532 0.0061

VAL 1532 SER 1533 -0.0410

SER 1533 SER 1534 0.0033

SER 1534 GLY 1535 0.0029

GLY 1535 PHE 1536 0.0042

PHE 1536 PHE 1537 0.0056

PHE 1537 GLU 1538 0.0019

GLU 1538 ALA 1539 0.0037

ALA 1539 ALA 1540 0.0048

ALA 1540 GLN 1541 0.0056

GLN 1541 GLN 1542 0.0005

GLN 1542 LYS 1543 0.0056

LYS 1543 PHE 1544 0.0046

PHE 1544 ALA 1545 0.0051

ALA 1545 ALA 1546 0.0051

ALA 1546 PHE 1547 0.0005

PHE 1547 ASP 1548 0.0049

ASP 1548 ASP 1549 0.1393

ASP 1549 VAL 1550 0.0034

VAL 1550 ILE 1551 0.0076

ILE 1551 ARG 1552 0.0052

ARG 1552 PHE 1553 0.0080

PHE 1553 GLN 1554 0.0018

GLN 1554 LYS 1555 0.0059

LYS 1555 LEU 1556 0.0029

LEU 1556 ASP 1557 0.0045

ASP 1557 ILE 1558 0.0055

ILE 1558 GLU 1559 0.0034

GLU 1559 LYS 1560 0.0079

LYS 1560 ASP 1561 0.0066

ASP 1561 ILE 1562 0.0046

ILE 1562 GLU 1563 0.0075

GLU 1563 MET 1564 0.0080

MET 1564 GLN 1565 -0.0315

GLN 1565 GLY 1566 0.0056

GLY 1566 PHE 1567 0.0044

PHE 1567 GLU 1568 0.0056

GLU 1568 CYS 1569 0.0053

CYS 1569 GLY 1570 0.0042

GLY 1570 SER 1571 0.0033

SER 1571 TYR 1572 0.0020

TYR 1572 ASP 1573 0.0030

ASP 1573 LEU 1574 0.0049

LEU 1574 VAL 1575 0.0051

VAL 1575 ILE 1576 0.0033

ILE 1576 ALA 1577 0.0055

ALA 1577 SER 1578 0.0030

SER 1578 GLN 1579 0.0054

GLN 1579 VAL 1580 0.0013

VAL 1580 LEU 1581 0.0662

LEU 1581 HIS 1582 0.0118

HIS 1582 ALA 1583 0.0092

ALA 1583 THR 1584 0.0028

THR 1584 GLY 1585 0.0040

GLY 1585 LYS 1586 0.0115

LYS 1586 MET 1587 0.0055

MET 1587 GLU 1588 0.0084

GLU 1588 HIS 1589 0.0088

HIS 1589 THR 1590 0.0037

THR 1590 MET 1591 0.0097

MET 1591 ALA 1592 0.0038

ALA 1592 ASN 1593 0.0117

ASN 1593 VAL 1594 0.0006

VAL 1594 ARG 1595 0.0112

ARG 1595 LYS 1596 0.0072

LYS 1596 LEU 1597 -0.0803

LEU 1597 LEU 1598 0.0083

LEU 1598 LYS 1599 0.0092

LYS 1599 PRO 1600 0.0097

PRO 1600 GLY 1601 0.0011

GLY 1601 GLY 1602 0.0088

GLY 1602 LYS 1603 0.0041

LYS 1603 LEU 1604 0.0099

LEU 1604 LEU 1605 0.0019

LEU 1605 LEU 1606 0.0096

LEU 1606 VAL 1607 0.0046

VAL 1607 GLU 1608 0.0091

GLU 1608 THR 1609 0.0087

THR 1609 THR 1610 0.0098

THR 1610 ARG 1611 0.0071

ARG 1611 ASP 1612 0.0100

ASP 1612 GLU 1613 -0.0759

GLU 1613 MET 1614 0.0320

MET 1614 ASP 1615 0.0302

ASP 1615 LEU 1616 0.0120

LEU 1616 GLN 1617 0.0203

GLN 1617 LEU 1618 0.0271

LEU 1618 VAL 1619 0.0321

VAL 1619 PHE 1620 0.0052

PHE 1620 GLY 1621 0.0275

GLY 1621 LEU 1622 0.0318

LEU 1622 LEU 1623 0.0179

LEU 1623 PRO 1624 0.0031

PRO 1624 GLY 1625 0.0323

GLY 1625 TRP 1626 0.0186

TRP 1626 TRP 1627 0.0192

TRP 1627 LEU 1628 0.0092

LEU 1628 SER 1629 -0.0263

SER 1629 SER 1630 0.0112

SER 1630 GLU 1631 0.0180

GLU 1631 GLU 1632 0.0196

GLU 1632 GLU 1633 0.0058

GLU 1633 ARG 1634 0.0232

ARG 1634 GLN 1635 0.0220

GLN 1635 MET 1636 0.0018

MET 1636 SER 1637 0.0215

SER 1637 PRO 1638 0.0182

PRO 1638 SER 1639 0.0149

SER 1639 LEU 1640 0.0230

LEU 1640 SER 1641 0.0120

SER 1641 THR 1642 0.0227

THR 1642 ASN 1643 0.0195

ASN 1643 SER 1644 0.0079

SER 1644 TRP 1645 -0.0375

TRP 1645 GLU 1646 0.0136

GLU 1646 LYS 1647 0.0046

LYS 1647 VAL 1648 0.0121

VAL 1648 LEU 1649 0.0137

LEU 1649 LYS 1650 0.0108

LYS 1650 LYS 1651 0.0056

LYS 1651 THR 1652 0.0137

THR 1652 GLY 1653 0.0138

GLY 1653 PHE 1654 0.0012

PHE 1654 ASP 1655 0.0117

ASP 1655 GLY 1656 0.0073

GLY 1656 LEU 1657 0.0012

LEU 1657 ASP 1658 0.0120

ASP 1658 ILE 1659 0.0029

ILE 1659 GLU 1660 0.0110

GLU 1660 LEU 1661 0.0099

LEU 1661 ARG 1662 0.0126

ARG 1662 ASP 1663 0.0108

ASP 1663 CYS 1664 0.0083

CYS 1664 ASP 1665 0.0160

ASP 1665 SER 1666 0.0162

SER 1666 ASP 1667 0.0086

ASP 1667 GLU 1668 0.0139

GLU 1668 PHE 1669 0.0160

PHE 1669 TYR 1670 0.0083

TYR 1670 SER 1671 0.0074

SER 1671 PHE 1672 0.0130

PHE 1672 SER 1673 0.0132

SER 1673 VAL 1674 0.0154

VAL 1674 MET 1675 0.0053

MET 1675 MET 1676 0.0117

MET 1676 ALA 1677 -0.0061

ALA 1677 THR 1678 0.0048

THR 1678 ALA 1679 0.0019

ALA 1679 SER 1680 0.0037

SER 1680 SER 1681 0.0062

SER 1681 THR 1682 0.0023

THR 1682 ILE 1683 0.0057

ILE 1683 ALA 1684 0.0033

ALA 1684 SER 1685 0.0058

SER 1685 SER 1686 0.0061

SER 1686 SER 1687 0.0051

SER 1687 MET 1688 0.0019

MET 1688 ALA 1689 0.0062

ALA 1689 PHE 1690 0.0011

PHE 1690 ALA 1691 0.0037

ALA 1691 ILE 1692 0.0016

ILE 1692 VAL 1693 -0.0268

VAL 1693 TYR 1694 0.0036

TYR 1694 GLY 1695 0.0022

GLY 1695 GLU 1696 0.0079

GLU 1696 VAL 1697 0.0114

VAL 1697 PRO 1698 0.0017

PRO 1698 LEU 1699 0.0102

LEU 1699 PRO 1700 0.0113

PRO 1700 ASP 1701 0.0016

ASP 1701 GLN 1702 0.0109

GLN 1702 PHE 1703 0.0107

PHE 1703 LEU 1704 0.0085

LEU 1704 ASP 1705 0.0036

ASP 1705 ASP 1706 0.0116

ASP 1706 MET 1707 0.0115

MET 1707 LYS 1708 0.0043

LYS 1708 THR 1709 0.0034

THR 1709 ALA 1710 0.0097

ALA 1710 ILE 1711 0.0105

ILE 1711 SER 1712 0.0021

SER 1712 SER 1713 0.0107

SER 1713 SER 1714 0.0106

SER 1714 ALA 1715 0.0097

ALA 1715 VAL 1716 0.0032

VAL 1716 SER 1717 0.0086

SER 1717 ASP 1718 0.0070

ASP 1718 PRO 1719 0.0025

PRO 1719 VAL 1720 0.0098

VAL 1720 VAL 1721 0.0018

VAL 1721 GLY 1722 0.0067

GLY 1722 HIS 1723 0.0015

HIS 1723 LEU 1724 0.0101

LEU 1724 ASP 1725 -0.0065

ASP 1725 SER 1726 0.0021

SER 1726 ILE 1727 0.0065

ILE 1727 ASP 1728 0.0054

ASP 1728 ALA 1729 0.0108

ALA 1729 THR 1730 0.0061

THR 1730 GLY 1731 0.0061

GLY 1731 LYS 1732 0.0098

LYS 1732 PHE 1733 0.0087

PHE 1733 CYS 1734 0.0025

CYS 1734 ILE 1735 0.0074

ILE 1735 PHE 1736 0.0016

PHE 1736 ILE 1737 0.0074

ILE 1737 GLU 1738 0.0010

GLU 1738 ASP 1739 0.0066

ASP 1739 PRO 1740 0.0059

PRO 1740 GLU 1741 -0.0102

GLU 1741 THR 1742 0.0109

THR 1742 ASP 1743 0.0111

ASP 1743 ILE 1744 0.0089

ILE 1744 LEU 1745 0.0109

LEU 1745 SER 1746 0.0005

SER 1746 SER 1747 0.0109

SER 1747 PRO 1748 0.0035

PRO 1748 ASP 1749 0.0110

ASP 1749 GLU 1750 0.0085

GLU 1750 LYS 1751 0.0047

LYS 1751 SER 1752 0.0112

SER 1752 TYR 1753 0.0115

TYR 1753 ALA 1754 0.0058

ALA 1754 SER 1755 0.0073

SER 1755 ILE 1756 0.0113

ILE 1756 GLN 1757 0.0344

GLN 1757 LYS 1758 0.0036

LYS 1758 LEU 1759 0.0099

LEU 1759 VAL 1760 0.0106

VAL 1760 THR 1761 0.0083

THR 1761 ARG 1762 0.0047

ARG 1762 CYS 1763 0.0100

CYS 1763 LYS 1764 0.0049

LYS 1764 GLY 1765 0.0066

GLY 1765 LEU 1766 0.0032

LEU 1766 ILE 1767 0.0090

ILE 1767 TRP 1768 0.0007

TRP 1768 VAL 1769 0.0091

VAL 1769 SER 1770 0.0007

SER 1770 ARG 1771 0.0063

ARG 1771 GLY 1772 0.0057

GLY 1772 GLY 1773 0.0287

GLY 1773 ALA 1774 0.0081

ALA 1774 MET 1775 0.0104

MET 1775 HIS 1776 0.0020

HIS 1776 GLY 1777 0.0096

GLY 1777 THR 1778 0.0093

THR 1778 ARG 1779 0.0106

ARG 1779 PRO 1780 0.0104

PRO 1780 ASN 1781 0.0103

ASN 1781 SER 1782 0.0014

SER 1782 SER 1783 0.0105

SER 1783 LEU 1784 0.0107

LEU 1784 LYS 1785 0.0009

LYS 1785 THR 1786 0.0101

THR 1786 GLY 1787 0.0085

GLY 1787 LEU 1788 0.0091

LEU 1788 LEU 1789 0.0027

LEU 1789 ARG 1790 0.0103

ARG 1790 THR 1791 0.0101

THR 1791 LEU 1792 0.0053

LEU 1792 ARG 1793 0.0059

ARG 1793 LEU 1794 0.0100

LEU 1794 GLU 1795 0.0104

GLU 1795 TYR 1796 0.0030

TYR 1796 THR 1797 0.0072

THR 1797 GLU 1798 0.0039

GLU 1798 LYS 1799 0.0079

LYS 1799 ARG 1800 0.0097

ARG 1800 PHE 1801 0.0005

PHE 1801 ILE 1802 0.0099

ILE 1802 SER 1803 0.0019

SER 1803 LEU 1804 0.0104

LEU 1804 ASP 1805 0.0176

ASP 1805 LEU 1806 0.0104

LEU 1806 ASP 1807 0.0063

ASP 1807 SER 1808 0.0017

SER 1808 ALA 1809 0.0100

ALA 1809 ARG 1810 0.0042

ARG 1810 PRO 1811 0.0101

PRO 1811 GLN 1812 0.0096

GLN 1812 TRP 1813 0.0024

TRP 1813 ASN 1814 0.0079

ASN 1814 HIS 1815 0.0008

HIS 1815 ASP 1816 0.0096

ASP 1816 SER 1817 0.0097

SER 1817 ILE 1818 0.0023

ILE 1818 THR 1819 0.0080

THR 1819 THR 1820 0.0078

THR 1820 ILE 1821 0.0333

ILE 1821 ASN 1822 0.0002

ASN 1822 GLU 1823 0.0033

GLU 1823 VAL 1824 0.0024

VAL 1824 LEU 1825 0.0022

LEU 1825 CYS 1826 0.0011

CYS 1826 GLY 1827 0.0029

GLY 1827 ALA 1828 0.0031

ALA 1828 LEU 1829 0.0004

LEU 1829 ALA 1830 0.0026

ALA 1830 GLN 1831 0.0032

GLN 1831 ASN 1832 0.0011

ASN 1832 ALA 1833 0.0033

ALA 1833 ASP 1834 0.0032

ASP 1834 SER 1835 0.0011

SER 1835 SER 1836 0.0020

SER 1836 ILE 1837 -0.0654

ILE 1837 LYS 1838 0.0043

LYS 1838 ASP 1839 0.0011

ASP 1839 SER 1840 0.0031

SER 1840 GLU 1841 0.0018

GLU 1841 PHE 1842 0.0059

PHE 1842 ALA 1843 0.0024

ALA 1843 GLU 1844 0.0060

GLU 1844 GLN 1845 0.0045

GLN 1845 ASP 1846 0.0060

ASP 1846 GLY 1847 0.0027

GLY 1847 GLN 1848 0.0038

GLN 1848 LEU 1849 0.0052

LEU 1849 PHE 1850 0.0060

PHE 1850 VAL 1851 0.0051

VAL 1851 PRO 1852 0.0052

PRO 1852 ARG 1853 -0.0557

ARG 1853 ILE 1854 0.0273

ILE 1854 SER 1855 0.0419

SER 1855 CYS 1856 0.0292

CYS 1856 ASP 1857 0.0098

ASP 1857 ILE 1858 0.0419

ILE 1858 ALA 1859 0.0133

ALA 1859 ARG 1860 0.0295

ARG 1860 ASN 1861 0.0338

ASN 1861 GLU 1862 0.0412

GLU 1862 ASP 1863 0.0036

ASP 1863 LEU 1864 0.0423

LEU 1864 SER 1865 0.0341

SER 1865 SER 1866 0.0312

SER 1866 ASP 1867 0.0240

ASP 1867 SER 1868 0.0212

SER 1868 ASN 1869 0.0820

ASN 1869 SER 1870 0.1601

SER 1870 PRO 1871 0.0916

PRO 1871 ALA 1872 0.1114

ALA 1872 GLN 1873 0.1581

GLN 1873 MET 1874 0.0764

MET 1874 GLU 1875 0.1550

GLU 1875 PRO 1876 0.1171

PRO 1876 PHE 1877 0.1267

PHE 1877 HIS 1878 0.1577

HIS 1878 GLN 1879 0.0083

GLN 1879 PRO 1880 0.1412

PRO 1880 GLY 1881 0.1218

GLY 1881 LYS 1882 0.1577

LYS 1882 LEU 1883 0.1034

LEU 1883 LEU 1884 0.1305

LEU 1884 GLN 1885 0.1541

GLN 1885 MET 1886 0.0995

MET 1886 GLY 1887 0.1324

GLY 1887 ILE 1888 0.1325

ILE 1888 LYS 1889 0.0568

LYS 1889 THR 1890 0.1060

THR 1890 PRO 1891 0.0468

PRO 1891 GLY 1892 0.0793

GLY 1892 LEU 1893 0.1240

LEU 1893 ILE 1894 0.1096

ILE 1894 ASP 1895 0.0962

ASP 1895 THR 1896 0.0613

THR 1896 LEU 1897 0.1212

LEU 1897 GLN 1898 0.0582

GLN 1898 PHE 1899 0.1195

PHE 1899 SER 1900 0.0399

SER 1900 LYS 1901 0.1363

LYS 1901 THR 1902 0.1564

THR 1902 ASP 1903 0.1118

ASP 1903 ALA 1904 0.1291

ALA 1904 THR 1905 0.1522

THR 1905 ASP 1906 0.1567

ASP 1906 ASN 1907 0.1363

ASN 1907 LEU 1908 0.0002

LEU 1908 PRO 1909 0.1442

PRO 1909 ASN 1910 0.1291

ASN 1910 ASP 1911 0.0271

ASP 1911 TYR 1912 0.1562

TYR 1912 ILE 1913 0.1459

ILE 1913 GLU 1914 0.1352

GLU 1914 ILE 1915 0.0965

ILE 1915 GLU 1916 0.1525

GLU 1916 PRO 1917 0.0172

PRO 1917 LYS 1918 0.1050

LYS 1918 ALA 1919 0.1041

ALA 1919 PHE 1920 0.1443

PHE 1920 GLY 1921 0.0762

GLY 1921 LEU 1922 0.1401

LEU 1922 ASN 1923 0.1341

ASN 1923 PHE 1924 0.1400

PHE 1924 ARG 1925 0.0781

ARG 1925 ASP 1926 0.0810

ASP 1926 VAL 1927 0.1380

VAL 1927 MET 1928 0.1443

MET 1928 VAL 1929 0.0287

VAL 1929 ALA 1930 0.1336

ALA 1930 MET 1931 0.1302

MET 1931 GLY 1932 0.1159

GLY 1932 GLN 1933 -0.0871

GLN 1933 LEU 1934 0.1397

LEU 1934 GLU 1935 0.0708

GLU 1935 GLU 1936 0.1375

GLU 1936 SER 1937 0.1050

SER 1937 ILE 1938 0.1230

ILE 1938 MET 1939 0.1129

MET 1939 GLY 1940 0.1198

GLY 1940 PHE 1941 0.0842

PHE 1941 GLU 1942 0.1204

GLU 1942 CYS 1943 0.1359

CYS 1943 ALA 1944 0.1293

ALA 1944 GLY 1945 0.0802

GLY 1945 VAL 1946 0.1199

VAL 1946 VAL 1947 0.1165

VAL 1947 ARG 1948 0.0104

ARG 1948 ARG 1949 0.1118

ARG 1949 VAL 1950 0.1324

VAL 1950 GLY 1951 0.1285

GLY 1951 PRO 1952 0.1529

PRO 1952 SER 1953 0.0754

SER 1953 SER 1954 0.1046

SER 1954 ALA 1955 0.1537

ALA 1955 GLY 1956 0.1089

GLY 1956 HIS 1957 0.0699

HIS 1957 ASN 1958 0.1434

ASN 1958 ILE 1959 0.1126

ILE 1959 LYS 1960 0.1015

LYS 1960 VAL 1961 0.0956

VAL 1961 GLY 1962 0.1172

GLY 1962 ASP 1963 0.0465

ASP 1963 ARG 1964 0.1140

ARG 1964 VAL 1965 0.2466

VAL 1965 CYS 1966 0.1340

CYS 1966 ALA 1967 0.1174

ALA 1967 LEU 1968 0.1431

LEU 1968 LEU 1969 0.0296

LEU 1969 GLY 1970 0.1043

GLY 1970 GLY 1971 0.1424

GLY 1971 GLN 1972 0.0947

GLN 1972 TRP 1973 0.1413

TRP 1973 THR 1974 0.0848

THR 1974 ASN 1975 0.1405

ASN 1975 THR 1976 0.1419

THR 1976 VAL 1977 0.1052

VAL 1977 ARG 1978 0.1388

ARG 1978 VAL 1979 0.0670

VAL 1979 HIS 1980 0.1347

HIS 1980 TRP 1981 0.0612

TRP 1981 HIS 1982 0.0660

HIS 1982 SER 1983 0.1422

SER 1983 VAL 1984 0.1438

VAL 1984 ALA 1985 0.0584

ALA 1985 PRO 1986 0.1440

PRO 1986 ILE 1987 0.1020

ILE 1987 PRO 1988 0.0871

PRO 1988 GLN 1989 0.1270

GLN 1989 ALA 1990 0.0758

ALA 1990 MET 1991 0.1409

MET 1991 ASP 1992 0.1086

ASP 1992 TRP 1993 0.0665

TRP 1993 GLU 1994 0.1158

GLU 1994 THR 1995 0.0607

THR 1995 ALA 1996 0.0947

ALA 1996 ALA 1997 0.1452

ALA 1997 SER 1998 0.0485

SER 1998 ILE 1999 0.1139

ILE 1999 PRO 2000 0.0600

PRO 2000 ILE 2001 0.1184

ILE 2001 VAL 2002 0.0139

VAL 2002 PHE 2003 0.0990

PHE 2003 VAL 2004 0.0676

VAL 2004 THR 2005 0.1179

THR 2005 ALA 2006 0.0017

ALA 2006 TYR 2007 0.1186

TYR 2007 ILE 2008 0.0745

ILE 2008 SER 2009 0.0919

SER 2009 LEU 2010 0.0140

LEU 2010 VAL 2011 0.1186

VAL 2011 LYS 2012 0.0466

LYS 2012 ILE 2013 0.3788

ILE 2013 ALA 2014 0.0075

ALA 2014 ARG 2015 0.0529

ARG 2015 MET 2016 0.0146

MET 2016 GLN 2017 0.0223

GLN 2017 ALA 2018 0.0135

ALA 2018 GLY 2019 0.0352

GLY 2019 GLU 2020 0.0311

GLU 2020 THR 2021 0.0588

THR 2021 VAL 2022 0.0248

VAL 2022 LEU 2023 0.0557

LEU 2023 ILE 2024 0.0401

ILE 2024 HIS 2025 0.0477

HIS 2025 ALA 2026 0.0566

ALA 2026 ALA 2027 0.0370

ALA 2027 SER 2028 0.0588

SER 2028 GLY 2029 -0.0481

GLY 2029 GLY 2030 0.0839

GLY 2030 VAL 2031 0.0952

VAL 2031 GLY 2032 0.0229

GLY 2032 GLN 2033 0.0775

GLN 2033 ALA 2034 0.0785

ALA 2034 ALA 2035 0.0874

ALA 2035 ILE 2036 0.0136

ILE 2036 ILE 2037 0.0955

ILE 2037 LEU 2038 0.0860

LEU 2038 ALA 2039 0.0582

ALA 2039 LYS 2040 0.0425

LYS 2040 HIS 2041 0.0843

HIS 2041 VAL 2042 0.0958

VAL 2042 GLY 2043 0.0153

GLY 2043 ALA 2044 0.0910

ALA 2044 GLU 2045 0.0285

GLU 2045 ILE 2046 0.0586

ILE 2046 PHE 2047 0.0795

PHE 2047 ALA 2048 0.0538

ALA 2048 THR 2049 0.0651

THR 2049 VAL 2050 0.0767

VAL 2050 GLY 2051 0.0688

GLY 2051 THR 2052 0.0522

THR 2052 ASP 2053 0.0130

ASP 2053 GLU 2054 0.0723

GLU 2054 LYS 2055 0.0665

LYS 2055 ARG 2056 0.0221

ARG 2056 ASP 2057 0.0620

ASP 2057 LEU 2058 0.0499

LEU 2058 LEU 2059 0.0783

LEU 2059 ILE 2060 0.0017

ILE 2060 LYS 2061 0.1217

LYS 2061 GLU 2062 0.0413

GLU 2062 TYR 2063 0.0725

TYR 2063 LYS 2064 0.0084

LYS 2064 ILE 2065 0.0665

ILE 2065 PRO 2066 0.0328

PRO 2066 ASP 2067 0.0710

ASP 2067 ASP 2068 0.0710

ASP 2068 HIS 2069 0.0310

HIS 2069 ILE 2070 0.0418

ILE 2070 PHE 2071 0.0564

PHE 2071 SER 2072 0.0356

SER 2072 SER 2073 0.0104

SER 2073 ARG 2074 0.0665

ARG 2074 ASN 2075 0.0572

ASN 2075 ALA 2076 0.0703

ALA 2076 LEU 2077 0.0737

LEU 2077 PHE 2078 0.0312

PHE 2078 ALA 2079 0.0309

ALA 2079 LYS 2080 0.0059

LYS 2080 SER 2081 0.0253

SER 2081 ILE 2082 0.0256

ILE 2082 ARG 2083 0.0301

ARG 2083 GLN 2084 0.0032

GLN 2084 ARG 2085 0.0319

ARG 2085 THR 2086 0.0264

THR 2086 ASN 2087 0.0168

ASN 2087 GLY 2088 0.0163

GLY 2088 LYS 2089 0.0206

LYS 2089 GLY 2090 0.0173

GLY 2090 VAL 2091 0.0216

VAL 2091 ASP 2092 0.0241

ASP 2092 VAL 2093 -0.0287

VAL 2093 VAL 2094 0.0089

VAL 2094 LEU 2095 0.0047

LEU 2095 ASN 2096 0.0111

ASN 2096 CYS 2097 0.0043

CYS 2097 LEU 2098 0.0151

LEU 2098 ALA 2099 0.0116

ALA 2099 GLY 2100 0.0147

GLY 2100 GLY 2101 0.0025

GLY 2101 LEU 2102 0.0138

LEU 2102 LEU 2103 0.0150

LEU 2103 GLN 2104 0.0107

GLN 2104 GLU 2105 0.0068

GLU 2105 SER 2106 0.0154

SER 2106 PHE 2107 0.0156

PHE 2107 ASP 2108 0.0055

ASP 2108 CYS 2109 0.0460

CYS 2109 LEU 2110 0.0186

LEU 2110 ALA 2111 0.0105

ALA 2111 ASP 2112 0.0198

ASP 2112 PHE 2113 0.0116

PHE 2113 GLY 2114 0.0184

GLY 2114 ARG 2115 0.0048

ARG 2115 PHE 2116 0.0136

PHE 2116 ILE 2117 0.0103

ILE 2117 GLU 2118 0.0102

GLU 2118 ILE 2119 0.0146

ILE 2119 GLY 2120 0.0174

GLY 2120 LYS 2121 0.0023

LYS 2121 ARG 2122 0.0198

ARG 2122 ASP 2123 0.0166

ASP 2123 ILE 2124 0.0154

ILE 2124 GLU 2125 0.1044

GLU 2125 LEU 2126 0.0013

LEU 2126 ASN 2127 0.0039

ASN 2127 HIS 2128 0.0023

HIS 2128 CYS 2129 0.0048

CYS 2129 LEU 2130 0.0047

LEU 2130 ASN 2131 0.0046

ASN 2131 MET 2132 0.0016

MET 2132 GLY 2133 0.0044

GLY 2133 MET 2134 0.0041

MET 2134 PHE 2135 0.0007

PHE 2135 ALA 2136 0.0049

ALA 2136 ARG 2137 0.0049

ARG 2137 SER 2138 0.0006

SER 2138 ALA 2139 0.0042

ALA 2139 THR 2140 0.0034

THR 2140 PHE 2141 -0.1139

PHE 2141 THR 2142 0.0293

THR 2142 ALA 2143 0.0477

ALA 2143 VAL 2144 0.0783

VAL 2144 ASP 2145 0.0150

ASP 2145 LEU 2146 0.0817

LEU 2146 ILE 2147 0.0157

ILE 2147 ALA 2148 0.0962

ALA 2148 ILE 2149 0.0824

ILE 2149 GLY 2150 0.0488

GLY 2150 ARG 2151 0.0503

ARG 2151 ASP 2152 0.0850

ASP 2152 ARG 2153 0.0557

ARG 2153 SER 2154 0.0883

SER 2154 TYR 2155 0.0815

TYR 2155 MET 2156 0.0239

MET 2156 PHE 2157 0.2574

PHE 2157 ALA 2158 0.1300

ALA 2158 GLU 2159 0.0245

GLU 2159 ALA 2160 0.1030

ALA 2160 LEU 2161 0.1196

LEU 2161 PRO 2162 0.1327

PRO 2162 LYS 2163 0.0238

LYS 2163 ILE 2164 0.1265

ILE 2164 MET 2165 0.1207

MET 2165 THR 2166 0.0987

THR 2166 LEU 2167 0.0482

LEU 2167 LEU 2168 0.1302

LEU 2168 GLN 2169 0.1307

GLN 2169 GLU 2170 0.0416

GLU 2170 LYS 2171 0.1107

LYS 2171 ALA 2172 0.1217

ALA 2172 ILE 2173 0.0332

ILE 2173 ARG 2174 0.1378

ARG 2174 PRO 2175 0.0626

PRO 2175 VAL 2176 0.1450

VAL 2176 THR 2177 0.1316

THR 2177 PRO 2178 0.1306

PRO 2178 ILE 2179 0.0162

ILE 2179 SER 2180 0.1166

SER 2180 ILE 2181 0.0644

ILE 2181 TYR 2182 0.0551

TYR 2182 LYS 2183 0.0413

LYS 2183 ILE 2184 0.0529

ILE 2184 GLY 2185 0.1303

GLY 2185 ASP 2186 0.0614

ASP 2186 ILE 2187 0.1430

ILE 2187 GLU 2188 0.1444

GLU 2188 THR 2189 -0.0599

THR 2189 ALA 2190 0.1362

ALA 2190 PHE 2191 0.1254

PHE 2191 ARG 2192 0.1239

ARG 2192 LEU 2193 0.0334

LEU 2193 MET 2194 0.1467

MET 2194 GLN 2195 0.1347

GLN 2195 ALA 2196 0.0577

ALA 2196 GLY 2197 0.1071

GLY 2197 LYS 2198 0.1109

LYS 2198 HIS 2199 0.1452

HIS 2199 MET 2200 0.0859

MET 2200 GLY 2201 0.1394

GLY 2201 LYS 2202 0.0118

LYS 2202 ILE 2203 0.0730

ILE 2203 VAL 2204 0.1018

VAL 2204 ILE 2205 -0.0229

ILE 2205 THR 2206 0.1353

THR 2206 ALA 2207 0.0030

ALA 2207 PRO 2208 0.1559

PRO 2208 GLU 2209 0.0220

GLU 2209 ASP 2210 0.1590

ASP 2210 ALA 2211 0.1461

ALA 2211 MET 2212 0.1132

MET 2212 VAL 2213 0.1599

VAL 2213 PRO 2214 0.1292

PRO 2214 VAL 2215 0.0707

VAL 2215 ILE 2216 0.1018

ILE 2216 THR 2217 0.0331

THR 2217 ARG 2218 0.1497

ARG 2218 PRO 2219 0.0024

PRO 2219 PRO 2220 0.1409

PRO 2220 LYS 2221 0.4710

LYS 2221 LEU 2222 0.0189

LEU 2222 GLN 2223 0.0061

GLN 2223 LEU 2224 0.0191

LEU 2224 ARG 2225 0.0116

ARG 2225 PRO 2226 0.0094

PRO 2226 ASP 2227 0.0192

ASP 2227 ALA 2228 0.0017

ALA 2228 SER 2229 0.0127

SER 2229 TYR 2230 0.0059

TYR 2230 LEU 2231 0.0096

LEU 2231 ILE 2232 0.0129

ILE 2232 VAL 2233 0.0076

VAL 2233 GLY 2234 0.0186

GLY 2234 GLY 2235 0.0034

GLY 2235 LEU 2236 0.0192

LEU 2236 GLY 2237 -0.0553

GLY 2237 GLY 2238 0.0334

GLY 2238 ILE 2239 0.0324

ILE 2239 GLY 2240 0.0228

GLY 2240 ARG 2241 0.0231

ARG 2241 SER 2242 0.0333

SER 2242 LEU 2243 0.0309

LEU 2243 CYS 2244 0.0189

CYS 2244 LYS 2245 0.0283

LYS 2245 ASN 2246 0.0336

ASN 2246 PHE 2247 0.0285

PHE 2247 VAL 2248 0.0157

VAL 2248 GLU 2249 0.0325

GLU 2249 ASN 2250 0.0336

ASN 2250 GLY 2251 0.0183

GLY 2251 ALA 2252 0.0256

ALA 2252 ARG 2253 0.0337

ARG 2253 SER 2254 0.0210

SER 2254 LEU 2255 0.0009

LEU 2255 VAL 2256 0.0181

VAL 2256 LEU 2257 0.0098

LEU 2257 LEU 2258 0.0135

LEU 2258 SER 2259 0.0145

SER 2259 ARG 2260 0.0171

ARG 2260 ASN 2261 0.0301

ASN 2261 ALA 2262 0.0006

ALA 2262 ASN 2263 0.0324

ASN 2263 VAL 2264 0.0293

VAL 2264 SER 2265 0.0015

SER 2265 GLN 2266 0.0308

GLN 2266 GLN 2267 0.0237

GLN 2267 SER 2268 0.0209

SER 2268 GLY 2269 0.1133

GLY 2269 GLU 2270 0.0428

GLU 2270 PHE 2271 0.0468

PHE 2271 LEU 2272 0.0350

LEU 2272 ASP 2273 0.0281

ASP 2273 GLU 2274 0.0466

GLU 2274 LEU 2275 0.0439

LEU 2275 ARG 2276 0.0289

ARG 2276 SER 2277 0.0378

SER 2277 THR 2278 0.0423

THR 2278 GLY 2279 0.0361

GLY 2279 CYS 2280 0.0258

CYS 2280 ILE 2281 0.0449

ILE 2281 VAL 2282 0.0004

VAL 2282 GLY 2283 0.0387

GLY 2283 VAL 2284 0.0023

VAL 2284 VAL 2285 -0.0332

VAL 2285 ASP 2286 0.0069

ASP 2286 CYS 2287 0.0135

CYS 2287 ASP 2288 0.0005

ASP 2288 ILE 2289 0.0199

ILE 2289 SER 2290 0.0038

SER 2290 SER 2291 0.0157

SER 2291 LYS 2292 0.0160

LYS 2292 THR 2293 0.0127

THR 2293 GLN 2294 0.0175

GLN 2294 VAL 2295 0.0192

VAL 2295 GLU 2296 0.0148

GLU 2296 ALA 2297 0.0144

ALA 2297 THR 2298 0.0194

THR 2298 MET 2299 0.0180

MET 2299 LEU 2300 0.0122

LEU 2300 ARG 2301 0.0028

ARG 2301 LEU 2302 0.0227

LEU 2302 LYS 2303 0.0177

LYS 2303 LYS 2304 0.0110

LYS 2304 ASP 2305 0.0228

ASP 2305 MET 2306 0.0218

MET 2306 LEU 2307 0.0217

LEU 2307 PRO 2308 0.0156

PRO 2308 ILE 2309 0.0025

ILE 2309 ARG 2310 0.0219

ARG 2310 GLY 2311 0.0068

GLY 2311 ILE 2312 0.0083

ILE 2312 VAL 2313 0.0121

VAL 2313 HIS 2314 0.0096

HIS 2314 ALA 2315 0.0193

ALA 2315 GLY 2316 0.0201

GLY 2316 MET 2317 0.0718

MET 2317 VAL 2318 0.0101

VAL 2318 LEU 2319 0.0013

LEU 2319 GLN 2320 0.0090

GLN 2320 ASP 2321 0.0015

ASP 2321 SER 2322 0.0055

SER 2322 VAL 2323 0.0025

VAL 2323 PHE 2324 0.0122

PHE 2324 GLU 2325 0.0079

GLU 2325 ARG 2326 0.0082

ARG 2326 MET 2327 0.0028

MET 2327 SER 2328 0.0084

SER 2328 LEU 2329 0.0081

LEU 2329 ASP 2330 0.0050

ASP 2330 ASP 2331 0.0106

ASP 2331 TYR 2332 0.0120

TYR 2332 ASN 2333 0.0082

ASN 2333 THR 2334 0.0111

THR 2334 ALA 2335 0.0134

ALA 2335 ILE 2336 0.0146

ILE 2336 ARG 2337 0.0028

ARG 2337 PRO 2338 0.0097

PRO 2338 LYS 2339 0.0111

LYS 2339 VAL 2340 0.0139

VAL 2340 GLN 2341 0.0075

GLN 2341 GLY 2342 0.0080

GLY 2342 SER 2343 0.0144

SER 2343 TRP 2344 0.0144

TRP 2344 ASN 2345 0.0049

ASN 2345 LEU 2346 0.0120

LEU 2346 HIS 2347 0.0133

HIS 2347 SER 2348 0.0125

SER 2348 GLY 2349 -0.0320

GLY 2349 LEU 2350 0.0165

LEU 2350 SER 2351 0.0173

SER 2351 ASP 2352 0.0002

ASP 2352 CYS 2353 0.0176

CYS 2353 ASP 2354 0.0175

ASP 2354 LEU 2355 0.0116

LEU 2355 ASP 2356 0.0173

ASP 2356 PHE 2357 0.0049

PHE 2357 PHE 2358 0.0111

PHE 2358 ILE 2359 0.0095

ILE 2359 MET 2360 0.0085

MET 2360 LEU 2361 0.0138

LEU 2361 SER 2362 0.0031

SER 2362 SER 2363 0.0062

SER 2363 LEU 2364 0.0062

LEU 2364 ALA 2365 -0.0137

ALA 2365 GLY 2366 0.0126

GLY 2366 VAL 2367 0.0084

VAL 2367 SER 2368 0.0066

SER 2368 GLY 2369 0.0130

GLY 2369 SER 2370 0.0126

SER 2370 ALA 2371 0.0092

ALA 2371 SER 2372 0.0085

SER 2372 GLN 2373 0.0057

GLN 2373 ALA 2374 0.0122

ALA 2374 ASN 2375 0.0014

ASN 2375 TYR 2376 0.0107

TYR 2376 THR 2377 0.0073

THR 2377 ALA 2378 0.0125

ALA 2378 GLY 2379 0.0007

GLY 2379 GLY 2380 0.0123

GLY 2380 ALA 2381 -0.0033

ALA 2381 TYR 2382 0.0061

TYR 2382 GLN 2383 0.0064

GLN 2383 ASP 2384 0.0086

ASP 2384 ALA 2385 0.0129

ALA 2385 LEU 2386 0.0008

LEU 2386 ALA 2387 0.0122

ALA 2387 LYS 2388 0.0088

LYS 2388 TYR 2389 0.0109

TYR 2389 ARG 2390 0.0017

ARG 2390 ARG 2391 0.0123

ARG 2391 ALA 2392 0.0106

ALA 2392 GLN 2393 0.0031

GLN 2393 GLY 2394 0.0100

GLY 2394 LEU 2395 0.0111

LEU 2395 SER 2396 0.0129

SER 2396 ALA 2397 0.0602

ALA 2397 VAL 2398 0.0101

VAL 2398 SER 2399 0.0061

SER 2399 ILE 2400 0.0184

ILE 2400 ASP 2401 0.0015

ASP 2401 LEU 2402 0.0219

LEU 2402 GLY 2403 0.0068

GLY 2403 MET 2404 0.0211

MET 2404 VAL 2405 0.0091

VAL 2405 GLN 2406 0.0196

GLN 2406 SER 2407 0.0085

SER 2407 VAL 2408 0.0167

VAL 2408 GLY 2409 0.0211

GLY 2409 TYR 2410 0.0077

TYR 2410 VAL 2411 0.0115

VAL 2411 ALA 2412 0.0181

ALA 2412 GLU 2413 -0.0403

GLU 2413 THR 2414 0.0042

THR 2414 LYS 2415 0.0070

LYS 2415 GLY 2416 0.0058

GLY 2416 VAL 2417 0.0162

VAL 2417 ALA 2418 0.0189

ALA 2418 GLU 2419 0.0014

GLU 2419 ARG 2420 0.0175

ARG 2420 LEU 2421 0.0131

LEU 2421 VAL 2422 0.0169

VAL 2422 ARG 2423 0.0027

ARG 2423 MET 2424 0.0180

MET 2424 GLY 2425 0.0176

GLY 2425 TYR 2426 0.0005

TYR 2426 SER 2427 0.0150

SER 2427 PRO 2428 0.0099

PRO 2428 ILE 2429 0.0218

ILE 2429 SER 2430 0.0022

SER 2430 GLU 2431 0.0073

GLU 2431 MET 2432 0.0129

MET 2432 GLU 2433 0.0055

GLU 2433 VAL 2434 0.0159

VAL 2434 LEU 2435 0.0012

LEU 2435 LYS 2436 0.0160

LYS 2436 ILE 2437 0.0058

ILE 2437 VAL 2438 0.0115

VAL 2438 GLU 2439 0.0060

GLU 2439 HIS 2440 0.0103

HIS 2440 ALA 2441 0.0133

ALA 2441 ILE 2442 0.0025

ILE 2442 THR 2443 0.0142

THR 2443 ASN 2444 0.0047

ASN 2444 PRO 2445 -0.0215

PRO 2445 PRO 2446 0.0043

PRO 2446 PRO 2447 0.0139

PRO 2447 GLU 2448 0.0093

GLU 2448 ALA 2449 0.0146

ALA 2449 SER 2450 0.0007

SER 2450 SER 2451 0.0139

SER 2451 ALA 2452 0.0080

ALA 2452 GLN 2453 0.0083

GLN 2453 ILE 2454 0.0141

ILE 2454 ILE 2455 0.0051

ILE 2455 THR 2456 0.0144

THR 2456 GLY 2457 0.0103

GLY 2457 ILE 2458 0.0019

ILE 2458 SER 2459 0.0086

SER 2459 THR 2460 0.0111

THR 2460 LYS 2461 -0.1125

LYS 2461 PRO 2462 0.0002

PRO 2462 GLY 2463 0.0078

GLY 2463 ARG 2464 0.0067

ARG 2464 HIS 2465 0.0026

HIS 2465 TRP 2466 0.0078

TRP 2466 THR 2467 0.0027

THR 2467 GLU 2468 0.0075

GLU 2468 SER 2469 0.0014

SER 2469 SER 2470 0.0085

SER 2470 TRP 2471 0.0020

TRP 2471 LEU 2472 0.0080

LEU 2472 GLN 2473 0.0041

GLN 2473 ASP 2474 0.0045

ASP 2474 ALA 2475 0.0082

ALA 2475 ARG 2476 0.0008

ARG 2476 PHE 2477 0.0193

PHE 2477 ALA 2478 0.0045

ALA 2478 THR 2479 0.0067

THR 2479 LEU 2480 0.0066

LEU 2480 ARG 2481 0.0021

ARG 2481 GLU 2482 0.0059

GLU 2482 ARG 2483 0.0067

ARG 2483 ALA 2484 0.0048

ALA 2484 ARG 2485 0.0033

ARG 2485 ASP 2486 0.0069

ASP 2486 VAL 2487 0.0068

VAL 2487 LYS 2488 0.0024

LYS 2488 GLU 2489 0.0054

GLU 2489 LEU 2490 0.0065

LEU 2490 SER 2491 0.0046

SER 2491 ASN 2492 0.0024

ASN 2492 SER 2493 0.1016

SER 2493 GLN 2494 0.0017

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** sdgklnrdh ***

CA strain for 22101813491974862

--- normal mode 19 ---

Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *