Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *

CA strain for 22101813491974862

--- normal mode 18 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
ASN 989 LYS 990 0.0027

LYS 990 ALA 991 0.0176

ALA 991 HIS 992 0.0032

HIS 992 ARG 993 0.0155

ARG 993 GLN 994 0.0065

GLN 994 ARG 995 0.0125

ARG 995 VAL 996 0.0138

VAL 996 HIS 997 0.0101

HIS 997 PRO 998 0.0024

PRO 998 PRO 999 0.0079

PRO 999 HIS 1000 0.0171

HIS 1000 ASP 1001 0.0068

ASP 1001 LEU 1002 0.0171

LEU 1002 LEU 1003 0.0129

LEU 1003 GLY 1004 0.0154

GLY 1004 SER 1005 0.0415

SER 1005 LEU 1006 0.0083

LEU 1006 ILE 1007 0.0152

ILE 1007 VAL 1008 0.0108

VAL 1008 GLY 1009 0.0144

GLY 1009 ARG 1010 0.0168

ARG 1010 ASP 1011 0.0046

ASP 1011 LEU 1012 0.0151

LEU 1012 ARG 1013 0.0159

ARG 1013 GLU 1014 0.0008

GLU 1014 PRO 1015 0.0145

PRO 1015 THR 1016 0.0005

THR 1016 TRP 1017 0.0134

TRP 1017 ARG 1018 0.0027

ARG 1018 HIS 1019 0.0111

HIS 1019 PHE 1020 0.0026

PHE 1020 ILE 1021 0.0764

ILE 1021 ARG 1022 0.0094

ARG 1022 VAL 1023 0.0137

VAL 1023 GLN 1024 0.0152

GLN 1024 ASP 1025 0.0013

ASP 1025 ILE 1026 0.0147

ILE 1026 PRO 1027 0.0096

PRO 1027 TRP 1028 0.0130

TRP 1028 ILE 1029 0.0127

ILE 1029 ARG 1030 0.0041

ARG 1030 ASP 1031 0.0131

ASP 1031 HIS 1032 0.0151

HIS 1032 VAL 1033 0.0028

VAL 1033 VAL 1034 0.0148

VAL 1034 GLN 1035 0.0016

GLN 1035 SER 1036 0.0137

SER 1036 ALA 1037 0.0593

ALA 1037 LEU 1038 0.0059

LEU 1038 VAL 1039 0.0056

VAL 1039 TYR 1040 0.0015

TYR 1040 PRO 1041 0.0100

PRO 1041 GLY 1042 0.0098

GLY 1042 ALA 1043 0.0059

ALA 1043 GLY 1044 0.0136

GLY 1044 PHE 1045 0.0127

PHE 1045 ILE 1046 0.0043

ILE 1046 CYS 1047 0.0134

CYS 1047 MET 1048 0.0134

MET 1048 ALA 1049 0.0070

ALA 1049 MET 1050 0.0083

MET 1050 GLU 1051 0.0135

GLU 1051 ALA 1052 0.0136

ALA 1052 MET 1053 0.0013

MET 1053 VAL 1054 0.0155

VAL 1054 GLN 1055 0.0170

GLN 1055 LEU 1056 0.0142

LEU 1056 HIS 1057 0.0066

HIS 1057 GLU 1058 0.0171

GLU 1058 LEU 1059 0.0169

LEU 1059 ARG 1060 0.0091

ARG 1060 ASP 1061 0.0095

ASP 1061 SER 1062 0.0105

SER 1062 GLN 1063 0.0128

GLN 1063 SER 1064 0.0143

SER 1064 ARG 1065 0.0169

ARG 1065 LYS 1066 0.0127

LYS 1066 VAL 1067 0.0041

VAL 1067 ALA 1068 0.0168

ALA 1068 GLY 1069 -0.0043

GLY 1069 TYR 1070 0.0066

TYR 1070 ARG 1071 0.0121

ARG 1071 LEU 1072 0.0038

LEU 1072 ALA 1073 0.0124

ALA 1073 GLU 1074 0.0049

GLU 1074 VAL 1075 0.0082

VAL 1075 ASP 1076 0.0022

ASP 1076 ILE 1077 0.0052

ILE 1077 LEU 1078 0.0090

LEU 1078 ARG 1079 0.0060

ARG 1079 ALA 1080 0.0118

ALA 1080 MET 1081 0.0127

MET 1081 LEU 1082 0.0035

LEU 1082 ILE 1083 0.0129

ILE 1083 PRO 1084 0.0059

PRO 1084 ASP 1085 -0.0138

ASP 1085 THR 1086 0.0170

THR 1086 SER 1087 0.0126

SER 1087 GLU 1088 0.0134

GLU 1088 GLY 1089 0.0153

GLY 1089 LEU 1090 0.0135

LEU 1090 GLU 1091 0.0064

GLU 1091 ALA 1092 0.0094

ALA 1092 HIS 1093 0.0039

HIS 1093 ILE 1094 0.0056

ILE 1094 SER 1095 0.0090

SER 1095 LEU 1096 0.0031

LEU 1096 ARG 1097 0.0130

ARG 1097 PRO 1098 0.0023

PRO 1098 CYS 1099 0.0168

CYS 1099 SER 1100 0.0135

SER 1100 THR 1101 0.0336

THR 1101 LYS 1102 0.0161

LYS 1102 LEU 1103 0.0166

LEU 1103 LEU 1104 0.0086

LEU 1104 LEU 1105 0.0183

LEU 1105 THR 1106 0.0045

THR 1106 ASN 1107 0.0153

ASN 1107 GLU 1108 0.0149

GLU 1108 TRP 1109 0.0017

TRP 1109 TYR 1110 0.0078

TYR 1110 ASP 1111 0.0033

ASP 1111 PHE 1112 0.0105

PHE 1112 CYS 1113 0.0019

CYS 1113 VAL 1114 0.0101

VAL 1114 SER 1115 0.0073

SER 1115 SER 1116 0.0081

SER 1116 VAL 1117 0.0259

VAL 1117 GLY 1118 -0.0000

GLY 1118 ASP 1119 0.0107

ASP 1119 ASP 1120 0.0174

ASP 1120 ASP 1121 0.0007

ASP 1121 LYS 1122 0.0173

LYS 1122 PHE 1123 0.0086

PHE 1123 VAL 1124 0.0166

VAL 1124 ASP 1125 0.0079

ASP 1125 HIS 1126 0.0176

HIS 1126 CYS 1127 0.0037

CYS 1127 ARG 1128 0.0060

ARG 1128 GLY 1129 0.0045

GLY 1129 ARG 1130 0.0003

ARG 1130 ILE 1131 0.0127

ILE 1131 THR 1132 0.0011

THR 1132 ILE 1133 0.0006

ILE 1133 GLU 1134 0.0098

GLU 1134 PHE 1135 0.0033

PHE 1135 ASP 1136 0.0098

ASP 1136 THR 1137 0.0066

THR 1137 SER 1138 0.0059

SER 1138 GLY 1139 0.0113

GLY 1139 SER 1140 0.0021

SER 1140 ALA 1141 0.0100

ALA 1141 ASP 1142 0.0005

ASP 1142 THR 1143 0.0083

THR 1143 PRO 1144 0.0069

PRO 1144 ARG 1145 0.0038

ARG 1145 THR 1146 0.0068

THR 1146 SER 1147 0.0091

SER 1147 LEU 1148 0.0006

LEU 1148 ARG 1149 0.1195

ARG 1149 GLU 1150 0.0006

GLU 1150 ARG 1151 0.0007

ARG 1151 SER 1152 0.0012

SER 1152 ARG 1153 0.0002

ARG 1153 SER 1154 0.0010

SER 1154 THR 1155 0.0012

THR 1155 GLY 1156 0.0004

GLY 1156 LEU 1157 0.0006

LEU 1157 MET 1158 0.0004

MET 1158 ARG 1159 0.0003

ARG 1159 SER 1160 0.0008

SER 1160 VAL 1161 0.0002

VAL 1161 ASP 1162 0.0005

ASP 1162 PRO 1163 0.0008

PRO 1163 SER 1164 0.0002

SER 1164 ASN 1165 -0.2847

ASN 1165 LEU 1166 0.0065

LEU 1166 TYR 1167 0.0073

TYR 1167 SER 1168 0.0011

SER 1168 PHE 1169 0.0077

PHE 1169 LEU 1170 0.0065

LEU 1170 ARG 1171 0.0047

ARG 1171 ALA 1172 0.0027

ALA 1172 GLN 1173 0.0071

GLN 1173 GLY 1174 0.0079

GLY 1174 ILE 1175 0.0002

ILE 1175 TYR 1176 0.0074

TYR 1176 HIS 1177 0.0010

HIS 1177 GLY 1178 0.0075

GLY 1178 PRO 1179 0.0047

PRO 1179 ILE 1180 0.0029

ILE 1180 PHE 1181 0.0048

PHE 1181 GLN 1182 0.0036

GLN 1182 ASN 1183 0.0004

ASN 1183 LEU 1184 0.0037

LEU 1184 LYS 1185 0.0038

LYS 1185 THR 1186 0.0038

THR 1186 ILE 1187 0.0035

ILE 1187 SER 1188 0.0035

SER 1188 SER 1189 0.0030

SER 1189 ARG 1190 0.0039

ARG 1190 LYS 1191 0.0029

LYS 1191 ASP 1192 0.0018

ASP 1192 HIS 1193 0.0025

HIS 1193 SER 1194 0.0038

SER 1194 GLU 1195 0.0022

GLU 1195 SER 1196 0.0037

SER 1196 SER 1197 0.1119

SER 1197 PHE 1198 0.0105

PHE 1198 VAL 1199 0.0104

VAL 1199 VAL 1200 0.0106

VAL 1200 ALA 1201 0.0046

ALA 1201 ASN 1202 0.0112

ASN 1202 THR 1203 0.0092

THR 1203 ALA 1204 0.0097

ALA 1204 SER 1205 0.0074

SER 1205 VAL 1206 0.0035

VAL 1206 MET 1207 0.0095

MET 1207 PRO 1208 0.0109

PRO 1208 ASN 1209 0.0062

ASN 1209 GLY 1210 0.0093

GLY 1210 PHE 1211 0.0088

PHE 1211 GLN 1212 0.0107

GLN 1212 SER 1213 -0.0150

SER 1213 PRO 1214 0.0033

PRO 1214 HIS 1215 0.0113

HIS 1215 VAL 1216 0.0081

VAL 1216 ILE 1217 0.0048

ILE 1217 HIS 1218 0.0013

HIS 1218 PRO 1219 0.0051

PRO 1219 THR 1220 0.0097

THR 1220 THR 1221 0.0030

THR 1221 LEU 1222 0.0113

LEU 1222 ASP 1223 0.0007

ASP 1223 SER 1224 0.0113

SER 1224 ILE 1225 0.0060

ILE 1225 PHE 1226 0.0065

PHE 1226 GLN 1227 0.0066

GLN 1227 GLY 1228 0.0057

GLY 1228 ALA 1229 0.0477

ALA 1229 TYR 1230 0.0005

TYR 1230 THR 1231 0.0032

THR 1231 ALA 1232 0.0032

ALA 1232 LEU 1233 0.0004

LEU 1233 PRO 1234 0.0028

PRO 1234 GLY 1235 0.0033

GLY 1235 ALA 1236 0.0025

ALA 1236 GLY 1237 0.0023

GLY 1237 LEU 1238 0.0013

LEU 1238 ASP 1239 0.0032

ASP 1239 GLN 1240 0.0036

GLN 1240 ASN 1241 0.0012

ASN 1241 THR 1242 0.0036

THR 1242 ALA 1243 0.0026

ALA 1243 MET 1244 0.0010

MET 1244 ILE 1245 0.0043

ILE 1245 PRO 1246 0.0013

PRO 1246 ARG 1247 0.0108

ARG 1247 SER 1248 0.0009

SER 1248 ILE 1249 0.0015

ILE 1249 GLN 1250 0.0055

GLN 1250 GLU 1251 0.0044

GLU 1251 LEU 1252 0.0106

LEU 1252 TYR 1253 0.0027

TYR 1253 LEU 1254 0.0109

LEU 1254 SER 1255 0.0026

SER 1255 SER 1256 0.0096

SER 1256 ALA 1257 0.0106

ALA 1257 LEU 1258 0.0004

LEU 1258 THR 1259 0.0104

THR 1259 SER 1260 0.0029

SER 1260 ASP 1261 0.0043

ASP 1261 VAL 1262 0.0017

VAL 1262 GLY 1263 0.0074

GLY 1263 GLN 1264 0.0034

GLN 1264 CYS 1265 0.0070

CYS 1265 LEU 1266 0.0075

LEU 1266 VAL 1267 0.0075

VAL 1267 SER 1268 0.0065

SER 1268 ASP 1269 0.0073

ASP 1269 THR 1270 0.0038

THR 1270 SER 1271 0.0073

SER 1271 LEU 1272 0.0028

LEU 1272 ILE 1273 0.0072

ILE 1273 ARG 1274 0.0009

ARG 1274 TYR 1275 0.0010

TYR 1275 ASP 1276 0.0021

ASP 1276 GLY 1277 0.0086

GLY 1277 GLN 1278 0.0082

GLN 1278 SER 1279 0.0005

SER 1279 PHE 1280 0.0021

PHE 1280 THR 1281 0.0006

THR 1281 VAL 1282 0.0038

VAL 1282 ASN 1283 0.0003

ASN 1283 VAL 1284 0.0079

VAL 1284 ASP 1285 0.0013

ASP 1285 VAL 1286 0.0082

VAL 1286 SER 1287 0.0034

SER 1287 SER 1288 0.0082

SER 1288 LYS 1289 0.0080

LYS 1289 ALA 1290 0.0022

ALA 1290 ASP 1291 0.0061

ASP 1291 SER 1292 0.0072

SER 1292 GLU 1293 0.0040

GLU 1293 HIS 1294 0.0008

HIS 1294 THR 1295 0.0069

THR 1295 PRO 1296 0.0032

PRO 1296 VAL 1297 0.0076

VAL 1297 LEU 1298 0.0028

LEU 1298 GLU 1299 0.0077

GLU 1299 ILE 1300 0.0023

ILE 1300 LYS 1301 0.0079

LYS 1301 GLY 1302 0.0020

GLY 1302 LEU 1303 0.0050

LEU 1303 ARG 1304 0.0018

ARG 1304 ASN 1305 0.0025

ASN 1305 GLN 1306 0.0019

GLN 1306 SER 1307 0.0006

SER 1307 VAL 1308 0.0058

VAL 1308 GLY 1309 -0.0435

GLY 1309 GLN 1310 0.0026

GLN 1310 MET 1311 0.0153

MET 1311 ALA 1312 0.0024

ALA 1312 PRO 1313 0.0119

PRO 1313 GLN 1314 0.0170

GLN 1314 PRO 1315 0.0019

PRO 1315 GLY 1316 0.0153

GLY 1316 ASP 1317 0.0096

ASP 1317 SER 1318 0.0148

SER 1318 SER 1319 0.0179

SER 1319 ASN 1320 0.0023

ASN 1320 ASN 1321 0.0167

ASN 1321 ASP 1322 0.0038

ASP 1322 LEU 1323 0.0162

LEU 1323 CYS 1324 0.0046

CYS 1324 PHE 1325 0.1836

PHE 1325 LYS 1326 0.0084

LYS 1326 LEU 1327 0.0064

LEU 1327 ASP 1328 0.0209

ASP 1328 TRP 1329 0.0062

TRP 1329 ALA 1330 0.0206

ALA 1330 PRO 1331 0.0125

PRO 1331 ASP 1332 0.0204

ASP 1332 ILE 1333 0.0182

ILE 1333 SER 1334 0.0133

SER 1334 SER 1335 0.0073

SER 1335 VAL 1336 0.0189

VAL 1336 LYS 1337 0.0142

LYS 1337 GLN 1338 0.0165

GLN 1338 GLU 1339 0.0168

GLU 1339 ARG 1340 0.0180

ARG 1340 LEU 1341 -0.4076

LEU 1341 LYS 1342 0.0620

LYS 1342 GLU 1343 0.0775

GLU 1343 LYS 1344 0.0970

LYS 1344 PHE 1345 0.0651

PHE 1345 GLY 1346 0.0503

GLY 1346 PHE 1347 0.1104

PHE 1347 PRO 1348 0.1146

PRO 1348 LEU 1349 0.0260

LEU 1349 ASP 1350 0.1291

ASP 1350 PRO 1351 0.0775

PRO 1351 THR 1352 0.1268

THR 1352 GLU 1353 0.1227

GLU 1353 ALA 1354 0.0841

ALA 1354 ASP 1355 0.1019

ASP 1355 ILE 1356 0.1292

ILE 1356 ILE 1357 0.2533

ILE 1357 MET 1358 0.1033

MET 1358 GLY 1359 0.1777

GLY 1359 LEU 1360 0.1919

LEU 1360 ARG 1361 0.1392

ARG 1361 GLN 1362 0.1242

GLN 1362 ALA 1363 0.1917

ALA 1363 CYS 1364 0.1865

CYS 1364 ILE 1365 0.0918

ILE 1365 HIS 1366 0.1674

HIS 1366 PHE 1367 0.1915

PHE 1367 ILE 1368 0.1700

ILE 1368 HIS 1369 0.0967

HIS 1369 ARG 1370 0.1820

ARG 1370 SER 1371 0.1918

SER 1371 LEU 1372 0.1441

LEU 1372 GLN 1373 0.1211

GLN 1373 SER 1374 0.2023

SER 1374 LEU 1375 0.2023

LEU 1375 THR 1376 0.0374

THR 1376 ALA 1377 0.1850

ALA 1377 PRO 1378 0.1995

PRO 1378 ASP 1379 0.0345

ASP 1379 ARG 1380 0.1955

ARG 1380 ASP 1381 0.1816

ASP 1381 GLN 1382 0.1404

GLN 1382 LEU 1383 0.0713

LEU 1383 ASP 1384 0.1105

ASP 1384 TRP 1385 0.1882

TRP 1385 HIS 1386 0.0899

HIS 1386 GLN 1387 0.1473

GLN 1387 LYS 1388 0.1368

LYS 1388 ARG 1389 0.0864

ARG 1389 PHE 1390 0.1880

PHE 1390 TYR 1391 0.0266

TYR 1391 ASP 1392 0.2004

ASP 1392 TRP 1393 0.0543

TRP 1393 MET 1394 0.1777

MET 1394 VAL 1395 0.0888

VAL 1395 LEU 1396 0.1321

LEU 1396 GLN 1397 0.1498

GLN 1397 ILE 1398 0.0759

ILE 1398 GLN 1399 0.1908

GLN 1399 LEU 1400 0.0331

LEU 1400 ALA 1401 0.1997

ALA 1401 GLU 1402 0.0567

GLU 1402 GLU 1403 0.1729

GLU 1403 ASP 1404 0.0958

ASP 1404 ARG 1405 0.1747

ARG 1405 LEU 1406 0.1626

LEU 1406 ALA 1407 0.1878

ALA 1407 PRO 1408 0.1881

PRO 1408 ASN 1409 0.0793

ASN 1409 SER 1410 0.2060

SER 1410 SER 1411 0.0008

SER 1411 ALA 1412 0.2047

ALA 1412 TRP 1413 0.1732

TRP 1413 LEU 1414 0.0498

LEU 1414 GLN 1415 0.1807

GLN 1415 CYS 1416 0.1298

CYS 1416 SER 1417 0.1907

SER 1417 SER 1418 0.2016

SER 1418 SER 1419 0.1359

SER 1419 ASP 1420 0.1552

ASP 1420 GLU 1421 0.2552

GLU 1421 GLN 1422 0.1735

GLN 1422 LYS 1423 0.0972

LYS 1423 LEU 1424 0.1898

LEU 1424 LEU 1425 0.1958

LEU 1425 GLU 1426 0.1359

GLU 1426 ASN 1427 0.1303

ASN 1427 VAL 1428 0.1958

VAL 1428 ARG 1429 0.1911

ARG 1429 ALA 1430 0.0911

ALA 1430 SER 1431 0.1709

SER 1431 SER 1432 0.1877

SER 1432 VAL 1433 0.1953

VAL 1433 ASN 1434 0.1264

ASN 1434 GLY 1435 0.1365

GLY 1435 GLN 1436 0.1948

GLN 1436 MET 1437 0.1585

MET 1437 VAL 1438 0.0953

VAL 1438 VAL 1439 0.1651

VAL 1439 HIS 1440 0.1891

HIS 1440 VAL 1441 0.1661

VAL 1441 GLY 1442 0.1172

GLY 1442 LYS 1443 0.1630

LYS 1443 SER 1444 0.1885

SER 1444 MET 1445 0.1811

MET 1445 LEU 1446 0.0125

LEU 1446 ALA 1447 0.1832

ALA 1447 ILE 1448 0.1284

ILE 1448 LEU 1449 0.1036

LEU 1449 ARG 1450 0.1300

ARG 1450 HIS 1451 0.1095

HIS 1451 GLU 1452 0.1903

GLU 1452 ILE 1453 0.0298

ILE 1453 ALA 1454 0.0944

ALA 1454 PRO 1455 0.1439

PRO 1455 LEU 1456 0.0235

LEU 1456 GLU 1457 0.1616

GLU 1457 LEU 1458 0.1472

LEU 1458 MET 1459 0.0895

MET 1459 LEU 1460 0.0849

LEU 1460 GLN 1461 0.1558

GLN 1461 ASP 1462 0.0836

ASP 1462 LYS 1463 0.1251

LYS 1463 LEU 1464 0.1169

LEU 1464 LEU 1465 0.1621

LEU 1465 TYR 1466 0.0011

TYR 1466 ARG 1467 0.1624

ARG 1467 TYR 1468 0.1040

TYR 1468 TYR 1469 0.1557

TYR 1469 THR 1470 0.0606

THR 1470 ASP 1471 0.1145

ASP 1471 ALA 1472 0.0551

ALA 1472 ILE 1473 0.1289

ILE 1473 LYS 1474 0.1030

LYS 1474 TRP 1475 0.1038

TRP 1475 ASP 1476 0.0338

ASP 1476 ARG 1477 0.1273

ARG 1477 SER 1478 0.1264

SER 1478 TYR 1479 0.0828

TYR 1479 GLN 1480 0.0710

GLN 1480 GLN 1481 0.1274

GLN 1481 ILE 1482 0.1276

ILE 1482 ASP 1483 0.0512

ASP 1483 GLN 1484 0.1063

GLN 1484 LEU 1485 0.0878

LEU 1485 VAL 1486 0.0588

VAL 1486 LYS 1487 0.0409

LYS 1487 LEU 1488 0.0703

LEU 1488 HIS 1489 0.0729

HIS 1489 ALA 1490 0.0502

ALA 1490 HIS 1491 0.0457

HIS 1491 LYS 1492 0.0726

LYS 1492 CYS 1493 0.0730

CYS 1493 PRO 1494 0.0676

PRO 1494 THR 1495 0.0722

THR 1495 ALA 1496 0.0102

ALA 1496 LYS 1497 0.0594

LYS 1497 ILE 1498 0.0119

ILE 1498 ILE 1499 0.0222

ILE 1499 GLU 1500 0.0205

GLU 1500 ILE 1501 0.0516

ILE 1501 GLY 1502 0.0728

GLY 1502 ALA 1503 0.0687

ALA 1503 GLY 1504 0.0698

GLY 1504 THR 1505 0.1065

THR 1505 GLY 1506 0.0391

GLY 1506 GLY 1507 0.1057

GLY 1507 CYS 1508 0.0955

CYS 1508 THR 1509 0.0576

THR 1509 ARG 1510 0.0984

ARG 1510 ALA 1511 0.1131

ALA 1511 VAL 1512 0.1007

VAL 1512 LEU 1513 0.0677

LEU 1513 ASP 1514 0.1061

ASP 1514 ALA 1515 0.1119

ALA 1515 LEU 1516 0.0877

LEU 1516 SER 1517 0.0329

SER 1517 ASN 1518 0.0441

ASN 1518 GLN 1519 0.0672

GLN 1519 GLY 1520 0.0716

GLY 1520 ILE 1521 0.0621

ILE 1521 ALA 1522 0.0449

ALA 1522 ARG 1523 0.0718

ARG 1523 CYS 1524 0.0651

CYS 1524 ALA 1525 0.0601

ALA 1525 GLN 1526 0.0300

GLN 1526 TYR 1527 0.0122

TYR 1527 ASP 1528 0.0422

ASP 1528 PHE 1529 0.0367

PHE 1529 THR 1530 0.0298

THR 1530 ASP 1531 0.0106

ASP 1531 VAL 1532 0.0410

VAL 1532 SER 1533 0.2112

SER 1533 SER 1534 0.0437

SER 1534 GLY 1535 0.0899

GLY 1535 PHE 1536 0.0837

PHE 1536 PHE 1537 0.0226

PHE 1537 GLU 1538 0.1062

GLU 1538 ALA 1539 0.1079

ALA 1539 ALA 1540 0.0918

ALA 1540 GLN 1541 0.0389

GLN 1541 GLN 1542 0.1133

GLN 1542 LYS 1543 0.1098

LYS 1543 PHE 1544 0.0634

PHE 1544 ALA 1545 0.0604

ALA 1545 ALA 1546 0.0669

ALA 1546 PHE 1547 0.1122

PHE 1547 ASP 1548 0.1134

ASP 1548 ASP 1549 0.1837

ASP 1549 VAL 1550 0.0814

VAL 1550 ILE 1551 0.0120

ILE 1551 ARG 1552 0.0902

ARG 1552 PHE 1553 0.0178

PHE 1553 GLN 1554 0.0742

GLN 1554 LYS 1555 0.0057

LYS 1555 LEU 1556 0.0962

LEU 1556 ASP 1557 0.0167

ASP 1557 ILE 1558 0.1079

ILE 1558 GLU 1559 0.0366

GLU 1559 LYS 1560 0.0880

LYS 1560 ASP 1561 0.0522

ASP 1561 ILE 1562 0.0273

ILE 1562 GLU 1563 0.0684

GLU 1563 MET 1564 0.0730

MET 1564 GLN 1565 0.1437

GLN 1565 GLY 1566 0.0004

GLY 1566 PHE 1567 0.0982

PHE 1567 GLU 1568 0.0613

GLU 1568 CYS 1569 0.0910

CYS 1569 GLY 1570 0.0770

GLY 1570 SER 1571 0.0718

SER 1571 TYR 1572 0.0933

TYR 1572 ASP 1573 0.0922

ASP 1573 LEU 1574 0.0487

LEU 1574 VAL 1575 0.0149

VAL 1575 ILE 1576 0.0784

ILE 1576 ALA 1577 0.0018

ALA 1577 SER 1578 0.0802

SER 1578 GLN 1579 0.0005

GLN 1579 VAL 1580 0.1021

VAL 1580 LEU 1581 0.1059

LEU 1581 HIS 1582 0.0183

HIS 1582 ALA 1583 0.0958

ALA 1583 THR 1584 0.1040

THR 1584 GLY 1585 0.0681

GLY 1585 LYS 1586 0.0830

LYS 1586 MET 1587 0.0601

MET 1587 GLU 1588 0.0824

GLU 1588 HIS 1589 0.1041

HIS 1589 THR 1590 0.0985

THR 1590 MET 1591 0.0661

MET 1591 ALA 1592 0.0929

ALA 1592 ASN 1593 0.1007

ASN 1593 VAL 1594 0.0923

VAL 1594 ARG 1595 0.0738

ARG 1595 LYS 1596 0.0930

LYS 1596 LEU 1597 -0.0235

LEU 1597 LEU 1598 0.0634

LEU 1598 LYS 1599 0.0273

LYS 1599 PRO 1600 0.0919

PRO 1600 GLY 1601 0.0902

GLY 1601 GLY 1602 0.0838

GLY 1602 LYS 1603 0.0673

LYS 1603 LEU 1604 0.0111

LEU 1604 LEU 1605 0.0878

LEU 1605 LEU 1606 0.0034

LEU 1606 VAL 1607 0.0699

VAL 1607 GLU 1608 0.0068

GLU 1608 THR 1609 0.0262

THR 1609 THR 1610 0.0917

THR 1610 ARG 1611 0.0423

ARG 1611 ASP 1612 0.0546

ASP 1612 GLU 1613 0.1712

GLU 1613 MET 1614 0.0421

MET 1614 ASP 1615 0.1499

ASP 1615 LEU 1616 0.1322

LEU 1616 GLN 1617 0.0692

GLN 1617 LEU 1618 0.1113

LEU 1618 VAL 1619 0.1154

VAL 1619 PHE 1620 0.1598

PHE 1620 GLY 1621 0.0604

GLY 1621 LEU 1622 0.1388

LEU 1622 LEU 1623 0.1108

LEU 1623 PRO 1624 0.1620

PRO 1624 GLY 1625 0.0210

GLY 1625 TRP 1626 0.1660

TRP 1626 TRP 1627 0.0966

TRP 1627 LEU 1628 0.1432

LEU 1628 SER 1629 0.2704

SER 1629 SER 1630 0.1128

SER 1630 GLU 1631 0.1237

GLU 1631 GLU 1632 0.0704

GLU 1632 GLU 1633 0.1009

GLU 1633 ARG 1634 0.1330

ARG 1634 GLN 1635 0.0226

GLN 1635 MET 1636 0.1314

MET 1636 SER 1637 0.0224

SER 1637 PRO 1638 0.0604

PRO 1638 SER 1639 0.0866

SER 1639 LEU 1640 0.1128

LEU 1640 SER 1641 0.1301

SER 1641 THR 1642 0.0107

THR 1642 ASN 1643 0.1294

ASN 1643 SER 1644 0.1181

SER 1644 TRP 1645 0.0469

TRP 1645 GLU 1646 0.0601

GLU 1646 LYS 1647 0.0758

LYS 1647 VAL 1648 0.0953

VAL 1648 LEU 1649 0.0069

LEU 1649 LYS 1650 0.0891

LYS 1650 LYS 1651 0.0681

LYS 1651 THR 1652 0.0833

THR 1652 GLY 1653 0.0045

GLY 1653 PHE 1654 0.0912

PHE 1654 ASP 1655 0.0849

ASP 1655 GLY 1656 0.0436

GLY 1656 LEU 1657 0.0953

LEU 1657 ASP 1658 0.0181

ASP 1658 ILE 1659 0.0842

ILE 1659 GLU 1660 0.0196

GLU 1660 LEU 1661 0.1285

LEU 1661 ARG 1662 0.0439

ARG 1662 ASP 1663 0.1145

ASP 1663 CYS 1664 0.1136

CYS 1664 ASP 1665 0.1151

ASP 1665 SER 1666 0.0057

SER 1666 ASP 1667 0.0683

ASP 1667 GLU 1668 0.0609

GLU 1668 PHE 1669 0.0976

PHE 1669 TYR 1670 0.0744

TYR 1670 SER 1671 0.1057

SER 1671 PHE 1672 0.0462

PHE 1672 SER 1673 0.0705

SER 1673 VAL 1674 0.0289

VAL 1674 MET 1675 0.1146

MET 1675 MET 1676 0.0505

MET 1676 ALA 1677 0.3159

ALA 1677 THR 1678 0.0522

THR 1678 ALA 1679 0.0713

ALA 1679 SER 1680 0.0006

SER 1680 SER 1681 0.0623

SER 1681 THR 1682 0.0068

THR 1682 ILE 1683 0.0667

ILE 1683 ALA 1684 0.0494

ALA 1684 SER 1685 0.0222

SER 1685 SER 1686 0.0777

SER 1686 SER 1687 0.0120

SER 1687 MET 1688 0.0686

MET 1688 ALA 1689 0.0567

ALA 1689 PHE 1690 0.0644

PHE 1690 ALA 1691 0.0776

ALA 1691 ILE 1692 0.0689

ILE 1692 VAL 1693 0.2176

VAL 1693 TYR 1694 0.0714

TYR 1694 GLY 1695 0.0624

GLY 1695 GLU 1696 0.0642

GLU 1696 VAL 1697 0.0723

VAL 1697 PRO 1698 0.0414

PRO 1698 LEU 1699 0.0675

LEU 1699 PRO 1700 0.0593

PRO 1700 ASP 1701 0.0229

ASP 1701 GLN 1702 0.0680

GLN 1702 PHE 1703 0.0183

PHE 1703 LEU 1704 0.0578

LEU 1704 ASP 1705 0.0432

ASP 1705 ASP 1706 0.0363

ASP 1706 MET 1707 0.0554

MET 1707 LYS 1708 0.0288

LYS 1708 THR 1709 0.1275

THR 1709 ALA 1710 0.0037

ALA 1710 ILE 1711 0.0764

ILE 1711 SER 1712 0.0242

SER 1712 SER 1713 0.0620

SER 1713 SER 1714 0.0372

SER 1714 ALA 1715 0.0548

ALA 1715 VAL 1716 0.0234

VAL 1716 SER 1717 0.0629

SER 1717 ASP 1718 0.0726

ASP 1718 PRO 1719 0.0573

PRO 1719 VAL 1720 0.0613

VAL 1720 VAL 1721 0.0724

VAL 1721 GLY 1722 0.0769

GLY 1722 HIS 1723 0.0655

HIS 1723 LEU 1724 0.0426

LEU 1724 ASP 1725 0.1222

ASP 1725 SER 1726 0.0141

SER 1726 ILE 1727 0.0722

ILE 1727 ASP 1728 0.0719

ASP 1728 ALA 1729 0.0302

ALA 1729 THR 1730 0.0690

THR 1730 GLY 1731 0.0729

GLY 1731 LYS 1732 0.0726

LYS 1732 PHE 1733 0.0303

PHE 1733 CYS 1734 0.0697

CYS 1734 ILE 1735 0.0629

ILE 1735 PHE 1736 0.0644

PHE 1736 ILE 1737 0.0715

ILE 1737 GLU 1738 0.0563

GLU 1738 ASP 1739 0.0732

ASP 1739 PRO 1740 0.0134

PRO 1740 GLU 1741 0.0585

GLU 1741 THR 1742 0.0839

THR 1742 ASP 1743 0.0355

ASP 1743 ILE 1744 0.0670

ILE 1744 LEU 1745 0.0299

LEU 1745 SER 1746 0.0523

SER 1746 SER 1747 0.0692

SER 1747 PRO 1748 0.0355

PRO 1748 ASP 1749 0.0529

ASP 1749 GLU 1750 0.0776

GLU 1750 LYS 1751 0.0193

LYS 1751 SER 1752 0.0766

SER 1752 TYR 1753 0.0400

TYR 1753 ALA 1754 0.0518

ALA 1754 SER 1755 0.0538

SER 1755 ILE 1756 0.0376

ILE 1756 GLN 1757 0.1291

GLN 1757 LYS 1758 0.0062

LYS 1758 LEU 1759 0.0743

LEU 1759 VAL 1760 0.0285

VAL 1760 THR 1761 0.0680

THR 1761 ARG 1762 0.0093

ARG 1762 CYS 1763 0.0742

CYS 1763 LYS 1764 0.0741

LYS 1764 GLY 1765 0.0409

GLY 1765 LEU 1766 0.0680

LEU 1766 ILE 1767 0.0666

ILE 1767 TRP 1768 0.0620

TRP 1768 VAL 1769 0.0741

VAL 1769 SER 1770 0.0384

SER 1770 ARG 1771 0.0587

ARG 1771 GLY 1772 0.0027

GLY 1772 GLY 1773 0.1237

GLY 1773 ALA 1774 0.0665

ALA 1774 MET 1775 0.0630

MET 1775 HIS 1776 0.0654

HIS 1776 GLY 1777 0.0717

GLY 1777 THR 1778 0.0571

THR 1778 ARG 1779 0.0664

ARG 1779 PRO 1780 0.0348

PRO 1780 ASN 1781 0.0523

ASN 1781 SER 1782 0.0399

SER 1782 SER 1783 0.0369

SER 1783 LEU 1784 0.0713

LEU 1784 LYS 1785 0.0275

LYS 1785 THR 1786 0.0596

THR 1786 GLY 1787 0.0267

GLY 1787 LEU 1788 0.0464

LEU 1788 LEU 1789 0.0882

LEU 1789 ARG 1790 0.0194

ARG 1790 THR 1791 0.0701

THR 1791 LEU 1792 0.0038

LEU 1792 ARG 1793 0.0697

ARG 1793 LEU 1794 0.0421

LEU 1794 GLU 1795 0.0486

GLU 1795 TYR 1796 0.0210

TYR 1796 THR 1797 0.0658

THR 1797 GLU 1798 0.0063

GLU 1798 LYS 1799 0.0649

LYS 1799 ARG 1800 0.0693

ARG 1800 PHE 1801 0.0583

PHE 1801 ILE 1802 0.0698

ILE 1802 SER 1803 0.0593

SER 1803 LEU 1804 0.0626

LEU 1804 ASP 1805 0.0997

ASP 1805 LEU 1806 0.0564

LEU 1806 ASP 1807 0.0506

ASP 1807 SER 1808 0.0661

SER 1808 ALA 1809 0.0663

ALA 1809 ARG 1810 0.0105

ARG 1810 PRO 1811 0.0186

PRO 1811 GLN 1812 0.0584

GLN 1812 TRP 1813 0.0171

TRP 1813 ASN 1814 0.0676

ASN 1814 HIS 1815 0.0595

HIS 1815 ASP 1816 0.0101

ASP 1816 SER 1817 0.0674

SER 1817 ILE 1818 0.0185

ILE 1818 THR 1819 0.0596

THR 1819 THR 1820 0.0207

THR 1820 ILE 1821 0.0724

ILE 1821 ASN 1822 0.0351

ASN 1822 GLU 1823 0.0059

GLU 1823 VAL 1824 0.0347

VAL 1824 LEU 1825 0.0150

LEU 1825 CYS 1826 0.0382

CYS 1826 GLY 1827 0.0030

GLY 1827 ALA 1828 0.0362

ALA 1828 LEU 1829 0.0247

LEU 1829 ALA 1830 0.0288

ALA 1830 GLN 1831 0.0164

GLN 1831 ASN 1832 0.0390

ASN 1832 ALA 1833 0.0289

ALA 1833 ASP 1834 0.0040

ASP 1834 SER 1835 0.0359

SER 1835 SER 1836 0.0286

SER 1836 ILE 1837 -0.1780

ILE 1837 LYS 1838 0.0159

LYS 1838 ASP 1839 0.0322

ASP 1839 SER 1840 0.0289

SER 1840 GLU 1841 0.0284

GLU 1841 PHE 1842 0.0299

PHE 1842 ALA 1843 0.0317

ALA 1843 GLU 1844 0.0264

GLU 1844 GLN 1845 0.0225

GLN 1845 ASP 1846 0.0289

ASP 1846 GLY 1847 0.0145

GLY 1847 GLN 1848 0.0215

GLN 1848 LEU 1849 0.0323

LEU 1849 PHE 1850 0.0056

PHE 1850 VAL 1851 0.0285

VAL 1851 PRO 1852 0.0119

PRO 1852 ARG 1853 -0.1160

ARG 1853 ILE 1854 0.0025

ILE 1854 SER 1855 0.0357

SER 1855 CYS 1856 0.0120

CYS 1856 ASP 1857 0.0321

ASP 1857 ILE 1858 0.0362

ILE 1858 ALA 1859 0.0339

ALA 1859 ARG 1860 0.0172

ARG 1860 ASN 1861 0.0339

ASN 1861 GLU 1862 0.0367

GLU 1862 ASP 1863 0.0255

ASP 1863 LEU 1864 0.0242

LEU 1864 SER 1865 0.0365

SER 1865 SER 1866 0.0364

SER 1866 ASP 1867 0.0002

ASP 1867 SER 1868 0.0363

SER 1868 ASN 1869 0.2202

ASN 1869 SER 1870 0.0346

SER 1870 PRO 1871 0.0147

PRO 1871 ALA 1872 0.0195

ALA 1872 GLN 1873 0.0368

GLN 1873 MET 1874 0.0011

MET 1874 GLU 1875 0.0462

GLU 1875 PRO 1876 0.0180

PRO 1876 PHE 1877 0.0466

PHE 1877 HIS 1878 0.0427

HIS 1878 GLN 1879 0.0211

GLN 1879 PRO 1880 0.0466

PRO 1880 GLY 1881 0.0150

GLY 1881 LYS 1882 0.0424

LYS 1882 LEU 1883 0.0467

LEU 1883 LEU 1884 0.0459

LEU 1884 GLN 1885 0.1058

GLN 1885 MET 1886 0.0290

MET 1886 GLY 1887 0.0100

GLY 1887 ILE 1888 0.0267

ILE 1888 LYS 1889 0.0128

LYS 1889 THR 1890 0.0274

THR 1890 PRO 1891 0.0268

PRO 1891 GLY 1892 0.0250

GLY 1892 LEU 1893 0.0249

LEU 1893 ILE 1894 0.0050

ILE 1894 ASP 1895 0.0290

ASP 1895 THR 1896 0.0152

THR 1896 LEU 1897 0.0179

LEU 1897 GLN 1898 0.0289

GLN 1898 PHE 1899 0.0288

PHE 1899 SER 1900 0.0128

SER 1900 LYS 1901 0.0894

LYS 1901 THR 1902 0.0333

THR 1902 ASP 1903 0.0368

ASP 1903 ALA 1904 0.0141

ALA 1904 THR 1905 0.0323

THR 1905 ASP 1906 0.0186

ASP 1906 ASN 1907 0.0359

ASN 1907 LEU 1908 0.0265

LEU 1908 PRO 1909 0.0307

PRO 1909 ASN 1910 0.0268

ASN 1910 ASP 1911 0.0351

ASP 1911 TYR 1912 0.0358

TYR 1912 ILE 1913 0.0117

ILE 1913 GLU 1914 0.0370

GLU 1914 ILE 1915 0.0227

ILE 1915 GLU 1916 0.0335

GLU 1916 PRO 1917 0.0229

PRO 1917 LYS 1918 0.0109

LYS 1918 ALA 1919 0.0355

ALA 1919 PHE 1920 0.0160

PHE 1920 GLY 1921 0.0363

GLY 1921 LEU 1922 0.0239

LEU 1922 ASN 1923 0.0268

ASN 1923 PHE 1924 0.0284

PHE 1924 ARG 1925 0.0128

ARG 1925 ASP 1926 0.0364

ASP 1926 VAL 1927 0.0365

VAL 1927 MET 1928 0.0161

MET 1928 VAL 1929 0.0281

VAL 1929 ALA 1930 0.0348

ALA 1930 MET 1931 0.0324

MET 1931 GLY 1932 0.0121

GLY 1932 GLN 1933 0.0038

GLN 1933 LEU 1934 0.0334

LEU 1934 GLU 1935 0.0119

GLU 1935 GLU 1936 0.0248

GLU 1936 SER 1937 0.0317

SER 1937 ILE 1938 0.0124

ILE 1938 MET 1939 0.0048

MET 1939 GLY 1940 0.0062

GLY 1940 PHE 1941 0.0315

PHE 1941 GLU 1942 0.0037

GLU 1942 CYS 1943 0.0198

CYS 1943 ALA 1944 0.0076

ALA 1944 GLY 1945 0.0335

GLY 1945 VAL 1946 0.0329

VAL 1946 VAL 1947 0.0221

VAL 1947 ARG 1948 0.0283

ARG 1948 ARG 1949 0.0210

ARG 1949 VAL 1950 0.0335

VAL 1950 GLY 1951 0.0101

GLY 1951 PRO 1952 0.0337

PRO 1952 SER 1953 0.0340

SER 1953 SER 1954 0.0224

SER 1954 ALA 1955 0.0136

ALA 1955 GLY 1956 0.0342

GLY 1956 HIS 1957 0.0322

HIS 1957 ASN 1958 0.0062

ASN 1958 ILE 1959 0.0307

ILE 1959 LYS 1960 0.0313

LYS 1960 VAL 1961 0.0339

VAL 1961 GLY 1962 0.0168

GLY 1962 ASP 1963 0.0342

ASP 1963 ARG 1964 0.0338

ARG 1964 VAL 1965 0.0721

VAL 1965 CYS 1966 0.0248

CYS 1966 ALA 1967 0.0012

ALA 1967 LEU 1968 0.0118

LEU 1968 LEU 1969 0.0172

LEU 1969 GLY 1970 0.0007

GLY 1970 GLY 1971 0.0354

GLY 1971 GLN 1972 0.0332

GLN 1972 TRP 1973 0.0221

TRP 1973 THR 1974 0.0338

THR 1974 ASN 1975 0.0153

ASN 1975 THR 1976 0.0349

THR 1976 VAL 1977 0.0328

VAL 1977 ARG 1978 0.0298

ARG 1978 VAL 1979 0.0352

VAL 1979 HIS 1980 0.0353

HIS 1980 TRP 1981 -0.0469

TRP 1981 HIS 1982 0.0347

HIS 1982 SER 1983 0.0337

SER 1983 VAL 1984 0.0075

VAL 1984 ALA 1985 0.0061

ALA 1985 PRO 1986 0.0074

PRO 1986 ILE 1987 0.0212

ILE 1987 PRO 1988 0.0017

PRO 1988 GLN 1989 0.0250

GLN 1989 ALA 1990 0.0255

ALA 1990 MET 1991 0.0121

MET 1991 ASP 1992 0.0332

ASP 1992 TRP 1993 0.0046

TRP 1993 GLU 1994 0.0345

GLU 1994 THR 1995 0.0333

THR 1995 ALA 1996 0.0254

ALA 1996 ALA 1997 0.0188

ALA 1997 SER 1998 0.0361

SER 1998 ILE 1999 0.0349

ILE 1999 PRO 2000 0.0119

PRO 2000 ILE 2001 0.0158

ILE 2001 VAL 2002 0.0292

VAL 2002 PHE 2003 0.0312

PHE 2003 VAL 2004 0.0140

VAL 2004 THR 2005 0.0231

THR 2005 ALA 2006 0.0240

ALA 2006 TYR 2007 0.0354

TYR 2007 ILE 2008 0.0023

ILE 2008 SER 2009 0.0340

SER 2009 LEU 2010 0.0197

LEU 2010 VAL 2011 0.0332

VAL 2011 LYS 2012 0.0137

LYS 2012 ILE 2013 0.0586

ILE 2013 ALA 2014 0.0302

ALA 2014 ARG 2015 0.0246

ARG 2015 MET 2016 0.0203

MET 2016 GLN 2017 0.0251

GLN 2017 ALA 2018 0.0091

ALA 2018 GLY 2019 0.0318

GLY 2019 GLU 2020 0.0121

GLU 2020 THR 2021 0.0322

THR 2021 VAL 2022 0.0318

VAL 2022 LEU 2023 0.0311

LEU 2023 ILE 2024 0.0286

ILE 2024 HIS 2025 0.0294

HIS 2025 ALA 2026 0.0216

ALA 2026 ALA 2027 0.0150

ALA 2027 SER 2028 0.0155

SER 2028 GLY 2029 -0.0029

GLY 2029 GLY 2030 0.0353

GLY 2030 VAL 2031 0.0164

VAL 2031 GLY 2032 0.0342

GLY 2032 GLN 2033 0.0024

GLN 2033 ALA 2034 0.0340

ALA 2034 ALA 2035 0.0221

ALA 2035 ILE 2036 0.0174

ILE 2036 ILE 2037 0.0225

ILE 2037 LEU 2038 0.0204

LEU 2038 ALA 2039 0.0333

ALA 2039 LYS 2040 0.0033

LYS 2040 HIS 2041 0.0355

HIS 2041 VAL 2042 0.0137

VAL 2042 GLY 2043 0.0308

GLY 2043 ALA 2044 0.0180

ALA 2044 GLU 2045 0.0345

GLU 2045 ILE 2046 0.0347

ILE 2046 PHE 2047 0.0278

PHE 2047 ALA 2048 0.0351

ALA 2048 THR 2049 0.0301

THR 2049 VAL 2050 0.0284

VAL 2050 GLY 2051 0.0335

GLY 2051 THR 2052 0.0096

THR 2052 ASP 2053 0.0120

ASP 2053 GLU 2054 0.0231

GLU 2054 LYS 2055 0.0235

LYS 2055 ARG 2056 0.0352

ARG 2056 ASP 2057 0.0003

ASP 2057 LEU 2058 0.0352

LEU 2058 LEU 2059 0.0268

LEU 2059 ILE 2060 0.0223

ILE 2060 LYS 2061 0.0172

LYS 2061 GLU 2062 0.0309

GLU 2062 TYR 2063 0.0165

TYR 2063 LYS 2064 0.0300

LYS 2064 ILE 2065 0.0028

ILE 2065 PRO 2066 0.0316

PRO 2066 ASP 2067 0.0298

ASP 2067 ASP 2068 0.0135

ASP 2068 HIS 2069 0.0273

HIS 2069 ILE 2070 0.0313

ILE 2070 PHE 2071 0.0119

PHE 2071 SER 2072 0.0271

SER 2072 SER 2073 0.0218

SER 2073 ARG 2074 0.0258

ARG 2074 ASN 2075 0.0237

ASN 2075 ALA 2076 0.0227

ALA 2076 LEU 2077 0.0341

LEU 2077 PHE 2078 0.0209

PHE 2078 ALA 2079 0.0096

ALA 2079 LYS 2080 0.0266

LYS 2080 SER 2081 0.0007

SER 2081 ILE 2082 0.0266

ILE 2082 ARG 2083 0.0125

ARG 2083 GLN 2084 0.0198

GLN 2084 ARG 2085 0.0100

ARG 2085 THR 2086 0.0192

THR 2086 ASN 2087 0.0224

ASN 2087 GLY 2088 0.0064

GLY 2088 LYS 2089 0.0267

LYS 2089 GLY 2090 0.0259

GLY 2090 VAL 2091 0.0211

VAL 2091 ASP 2092 0.0259

ASP 2092 VAL 2093 0.0382

VAL 2093 VAL 2094 0.0191

VAL 2094 LEU 2095 0.0153

LEU 2095 ASN 2096 0.0166

ASN 2096 CYS 2097 0.0183

CYS 2097 LEU 2098 0.0175

LEU 2098 ALA 2099 0.0062

ALA 2099 GLY 2100 0.0081

GLY 2100 GLY 2101 0.0188

GLY 2101 LEU 2102 0.0045

LEU 2102 LEU 2103 0.0165

LEU 2103 GLN 2104 0.0088

GLN 2104 GLU 2105 0.0113

GLU 2105 SER 2106 0.0139

SER 2106 PHE 2107 0.0055

PHE 2107 ASP 2108 0.0179

ASP 2108 CYS 2109 0.0154

CYS 2109 LEU 2110 0.0162

LEU 2110 ALA 2111 0.0191

ALA 2111 ASP 2112 0.0053

ASP 2112 PHE 2113 0.0185

PHE 2113 GLY 2114 0.0095

GLY 2114 ARG 2115 0.0194

ARG 2115 PHE 2116 0.0192

PHE 2116 ILE 2117 0.0173

ILE 2117 GLU 2118 0.0191

GLU 2118 ILE 2119 0.0136

ILE 2119 GLY 2120 0.0194

GLY 2120 LYS 2121 0.0108

LYS 2121 ARG 2122 0.0192

ARG 2122 ASP 2123 0.0112

ASP 2123 ILE 2124 0.0139

ILE 2124 GLU 2125 0.0266

GLU 2125 LEU 2126 0.0166

LEU 2126 ASN 2127 0.0056

ASN 2127 HIS 2128 0.0157

HIS 2128 CYS 2129 0.0101

CYS 2129 LEU 2130 0.0165

LEU 2130 ASN 2131 0.0146

ASN 2131 MET 2132 0.0071

MET 2132 GLY 2133 0.0169

GLY 2133 MET 2134 0.0099

MET 2134 PHE 2135 0.0088

PHE 2135 ALA 2136 0.0129

ALA 2136 ARG 2137 0.0077

ARG 2137 SER 2138 0.0158

SER 2138 ALA 2139 0.0052

ALA 2139 THR 2140 0.0164

THR 2140 PHE 2141 -0.0244

PHE 2141 THR 2142 0.0235

THR 2142 ALA 2143 0.0236

ALA 2143 VAL 2144 0.0168

VAL 2144 ASP 2145 0.0227

ASP 2145 LEU 2146 0.0169

LEU 2146 ILE 2147 0.0151

ILE 2147 ALA 2148 0.0086

ALA 2148 ILE 2149 0.0166

ILE 2149 GLY 2150 0.0212

GLY 2150 ARG 2151 0.0028

ARG 2151 ASP 2152 0.0181

ASP 2152 ARG 2153 0.0113

ARG 2153 SER 2154 0.0112

SER 2154 TYR 2155 0.0217

TYR 2155 MET 2156 0.0192

MET 2156 PHE 2157 0.0915

PHE 2157 ALA 2158 0.0315

ALA 2158 GLU 2159 0.0332

GLU 2159 ALA 2160 0.0310

ALA 2160 LEU 2161 0.0253

LEU 2161 PRO 2162 0.0241

PRO 2162 LYS 2163 0.0342

LYS 2163 ILE 2164 0.0325

ILE 2164 MET 2165 0.0220

MET 2165 THR 2166 0.0302

THR 2166 LEU 2167 0.0345

LEU 2167 LEU 2168 0.0284

LEU 2168 GLN 2169 0.0246

GLN 2169 GLU 2170 0.0330

GLU 2170 LYS 2171 0.0339

LYS 2171 ALA 2172 0.0222

ALA 2172 ILE 2173 -0.0080

ILE 2173 ARG 2174 0.0450

ARG 2174 PRO 2175 0.0304

PRO 2175 VAL 2176 0.0369

VAL 2176 THR 2177 0.0362

THR 2177 PRO 2178 0.0460

PRO 2178 ILE 2179 0.0378

ILE 2179 SER 2180 0.0411

SER 2180 ILE 2181 0.0459

ILE 2181 TYR 2182 0.0287

TYR 2182 LYS 2183 0.0449

LYS 2183 ILE 2184 0.0068

ILE 2184 GLY 2185 0.0456

GLY 2185 ASP 2186 0.0453

ASP 2186 ILE 2187 0.0258

ILE 2187 GLU 2188 0.0329

GLU 2188 THR 2189 -0.0724

THR 2189 ALA 2190 0.0384

ALA 2190 PHE 2191 0.0037

PHE 2191 ARG 2192 0.0380

ARG 2192 LEU 2193 0.0117

LEU 2193 MET 2194 0.0290

MET 2194 GLN 2195 0.0153

GLN 2195 ALA 2196 0.0242

ALA 2196 GLY 2197 0.0347

GLY 2197 LYS 2198 0.0042

LYS 2198 HIS 2199 0.0344

HIS 2199 MET 2200 0.0265

MET 2200 GLY 2201 0.0384

GLY 2201 LYS 2202 0.0301

LYS 2202 ILE 2203 0.0364

ILE 2203 VAL 2204 0.0381

VAL 2204 ILE 2205 -0.0334

ILE 2205 THR 2206 0.0279

THR 2206 ALA 2207 0.0123

ALA 2207 PRO 2208 0.0237

PRO 2208 GLU 2209 0.0184

GLU 2209 ASP 2210 0.0285

ASP 2210 ALA 2211 0.0267

ALA 2211 MET 2212 0.0143

MET 2212 VAL 2213 0.0198

VAL 2213 PRO 2214 0.0133

PRO 2214 VAL 2215 0.0089

VAL 2215 ILE 2216 0.0033

ILE 2216 THR 2217 0.0138

THR 2217 ARG 2218 0.0124

ARG 2218 PRO 2219 0.0064

PRO 2219 PRO 2220 0.0240

PRO 2220 LYS 2221 0.5486

LYS 2221 LEU 2222 0.1268

LEU 2222 GLN 2223 0.0784

GLN 2223 LEU 2224 0.1266

LEU 2224 ARG 2225 0.1100

ARG 2225 PRO 2226 0.0177

PRO 2226 ASP 2227 0.1237

ASP 2227 ALA 2228 0.0568

ALA 2228 SER 2229 0.1241

SER 2229 TYR 2230 0.0831

TYR 2230 LEU 2231 0.1062

LEU 2231 ILE 2232 0.1236

ILE 2232 VAL 2233 0.0966

VAL 2233 GLY 2234 0.1187

GLY 2234 GLY 2235 0.0495

GLY 2235 LEU 2236 0.0973

LEU 2236 GLY 2237 0.1174

GLY 2237 GLY 2238 0.1244

GLY 2238 ILE 2239 0.0825

ILE 2239 GLY 2240 0.1060

GLY 2240 ARG 2241 0.0224

ARG 2241 SER 2242 0.1117

SER 2242 LEU 2243 0.1058

LEU 2243 CYS 2244 0.0361

CYS 2244 LYS 2245 0.0936

LYS 2245 ASN 2246 0.0711

ASN 2246 PHE 2247 0.1244

PHE 2247 VAL 2248 0.0015

VAL 2248 GLU 2249 0.1244

GLU 2249 ASN 2250 0.0630

ASN 2250 GLY 2251 0.0942

GLY 2251 ALA 2252 0.1221

ALA 2252 ARG 2253 -0.0115

ARG 2253 SER 2254 0.1179

SER 2254 LEU 2255 0.1023

LEU 2255 VAL 2256 0.1152

VAL 2256 LEU 2257 0.1383

LEU 2257 LEU 2258 0.0844

LEU 2258 SER 2259 0.1446

SER 2259 ARG 2260 0.1336

ARG 2260 ASN 2261 0.0406

ASN 2261 ALA 2262 0.0796

ALA 2262 ASN 2263 0.0810

ASN 2263 VAL 2264 0.1446

VAL 2264 SER 2265 0.0666

SER 2265 GLN 2266 0.1158

GLN 2266 GLN 2267 0.0941

GLN 2267 SER 2268 0.1430

SER 2268 GLY 2269 -0.0791

GLY 2269 GLU 2270 0.1614

GLU 2270 PHE 2271 0.0548

PHE 2271 LEU 2272 0.1689

LEU 2272 ASP 2273 0.0156

ASP 2273 GLU 2274 0.1578

GLU 2274 LEU 2275 0.1072

LEU 2275 ARG 2276 0.1014

ARG 2276 SER 2277 0.0981

SER 2277 THR 2278 0.1161

THR 2278 GLY 2279 0.1691

GLY 2279 CYS 2280 0.0296

CYS 2280 ILE 2281 0.1675

ILE 2281 VAL 2282 0.1384

VAL 2282 GLY 2283 0.1457

GLY 2283 VAL 2284 0.1577

VAL 2284 VAL 2285 0.1849

VAL 2285 ASP 2286 0.1044

ASP 2286 CYS 2287 0.0143

CYS 2287 ASP 2288 0.0348

ASP 2288 ILE 2289 0.1009

ILE 2289 SER 2290 0.0427

SER 2290 SER 2291 0.1271

SER 2291 LYS 2292 0.1288

LYS 2292 THR 2293 0.0852

THR 2293 GLN 2294 0.0605

GLN 2294 VAL 2295 0.1304

VAL 2295 GLU 2296 0.1344

GLU 2296 ALA 2297 0.0423

ALA 2297 THR 2298 0.1128

THR 2298 MET 2299 0.1255

MET 2299 LEU 2300 0.1199

LEU 2300 ARG 2301 0.1534

ARG 2301 LEU 2302 0.1238

LEU 2302 LYS 2303 0.1207

LYS 2303 LYS 2304 0.0366

LYS 2304 ASP 2305 0.0864

ASP 2305 MET 2306 0.1155

MET 2306 LEU 2307 0.1195

LEU 2307 PRO 2308 0.0136

PRO 2308 ILE 2309 0.0813

ILE 2309 ARG 2310 0.1078

ARG 2310 GLY 2311 0.1087

GLY 2311 ILE 2312 0.1106

ILE 2312 VAL 2313 0.1221

VAL 2313 HIS 2314 0.0947

HIS 2314 ALA 2315 0.1175

ALA 2315 GLY 2316 0.1207

GLY 2316 MET 2317 -0.1476

MET 2317 VAL 2318 0.0757

VAL 2318 LEU 2319 0.0825

LEU 2319 GLN 2320 0.0403

GLN 2320 ASP 2321 0.0868

ASP 2321 SER 2322 0.0123

SER 2322 VAL 2323 0.0444

VAL 2323 PHE 2324 0.0690

PHE 2324 GLU 2325 0.0436

GLU 2325 ARG 2326 0.0666

ARG 2326 MET 2327 0.0696

MET 2327 SER 2328 0.0971

SER 2328 LEU 2329 0.0986

LEU 2329 ASP 2330 0.0271

ASP 2330 ASP 2331 0.0819

ASP 2331 TYR 2332 0.0882

TYR 2332 ASN 2333 0.2080

ASN 2333 THR 2334 0.0127

THR 2334 ALA 2335 0.0973

ALA 2335 ILE 2336 0.0749

ILE 2336 ARG 2337 0.0790

ARG 2337 PRO 2338 0.0287

PRO 2338 LYS 2339 0.0792

LYS 2339 VAL 2340 0.0377

VAL 2340 GLN 2341 0.0930

GLN 2341 GLY 2342 0.0052

GLY 2342 SER 2343 0.0964

SER 2343 TRP 2344 0.0593

TRP 2344 ASN 2345 0.0616

ASN 2345 LEU 2346 0.0486

LEU 2346 HIS 2347 0.0623

HIS 2347 SER 2348 0.0922

SER 2348 GLY 2349 0.0636

GLY 2349 LEU 2350 0.0921

LEU 2350 SER 2351 0.0638

SER 2351 ASP 2352 0.0451

ASP 2352 CYS 2353 0.0737

CYS 2353 ASP 2354 0.1033

ASP 2354 LEU 2355 0.1032

LEU 2355 ASP 2356 0.0981

ASP 2356 PHE 2357 0.0785

PHE 2357 PHE 2358 0.0725

PHE 2358 ILE 2359 0.1018

ILE 2359 MET 2360 0.0734

MET 2360 LEU 2361 0.1018

LEU 2361 SER 2362 0.0091

SER 2362 SER 2363 0.0938

SER 2363 LEU 2364 0.0747

LEU 2364 ALA 2365 -0.0202

ALA 2365 GLY 2366 0.0670

GLY 2366 VAL 2367 0.0917

VAL 2367 SER 2368 0.0919

SER 2368 GLY 2369 0.0707

GLY 2369 SER 2370 0.0794

SER 2370 ALA 2371 0.0664

ALA 2371 SER 2372 0.0923

SER 2372 GLN 2373 0.0803

GLN 2373 ALA 2374 0.0283

ALA 2374 ASN 2375 0.0816

ASN 2375 TYR 2376 0.0190

TYR 2376 THR 2377 0.0792

THR 2377 ALA 2378 0.0583

ALA 2378 GLY 2379 0.0370

GLY 2379 GLY 2380 0.0717

GLY 2380 ALA 2381 0.0373

ALA 2381 TYR 2382 0.0839

TYR 2382 GLN 2383 0.0158

GLN 2383 ASP 2384 0.0744

ASP 2384 ALA 2385 0.0382

ALA 2385 LEU 2386 0.0529

LEU 2386 ALA 2387 0.0574

ALA 2387 LYS 2388 0.0325

LYS 2388 TYR 2389 0.0785

TYR 2389 ARG 2390 0.0166

ARG 2390 ARG 2391 0.0841

ARG 2391 ALA 2392 0.0148

ALA 2392 GLN 2393 0.0743

GLN 2393 GLY 2394 0.0381

GLY 2394 LEU 2395 0.0499

LEU 2395 SER 2396 0.0481

SER 2396 ALA 2397 0.1580

ALA 2397 VAL 2398 0.0719

VAL 2398 SER 2399 0.0635

SER 2399 ILE 2400 0.0594

ILE 2400 ASP 2401 0.0493

ASP 2401 LEU 2402 0.0263

LEU 2402 GLY 2403 0.0712

GLY 2403 MET 2404 0.0488

MET 2404 VAL 2405 0.0041

VAL 2405 GLN 2406 0.0526

GLN 2406 SER 2407 0.0077

SER 2407 VAL 2408 0.0716

VAL 2408 GLY 2409 0.0501

GLY 2409 TYR 2410 0.0410

TYR 2410 VAL 2411 0.0683

VAL 2411 ALA 2412 0.0056

ALA 2412 GLU 2413 0.0662

GLU 2413 THR 2414 0.0223

THR 2414 LYS 2415 0.0690

LYS 2415 GLY 2416 0.0208

GLY 2416 VAL 2417 0.0622

VAL 2417 ALA 2418 0.0641

ALA 2418 GLU 2419 0.0561

GLU 2419 ARG 2420 0.0212

ARG 2420 LEU 2421 0.0698

LEU 2421 VAL 2422 0.0680

VAL 2422 ARG 2423 0.0282

ARG 2423 MET 2424 0.0506

MET 2424 GLY 2425 0.0665

GLY 2425 TYR 2426 0.0299

TYR 2426 SER 2427 0.0289

SER 2427 PRO 2428 0.0099

PRO 2428 ILE 2429 -0.1378

ILE 2429 SER 2430 0.0021

SER 2430 GLU 2431 0.0480

GLU 2431 MET 2432 0.0580

MET 2432 GLU 2433 0.0047

GLU 2433 VAL 2434 0.0561

VAL 2434 LEU 2435 0.0335

LEU 2435 LYS 2436 0.0541

LYS 2436 ILE 2437 0.0061

ILE 2437 VAL 2438 0.0553

VAL 2438 GLU 2439 0.0424

GLU 2439 HIS 2440 0.0248

HIS 2440 ALA 2441 0.0378

ALA 2441 ILE 2442 0.0375

ILE 2442 THR 2443 0.0583

THR 2443 ASN 2444 0.0108

ASN 2444 PRO 2445 0.0857

PRO 2445 PRO 2446 0.0076

PRO 2446 PRO 2447 0.0531

PRO 2447 GLU 2448 0.0052

GLU 2448 ALA 2449 0.0511

ALA 2449 SER 2450 0.0444

SER 2450 SER 2451 0.0158

SER 2451 ALA 2452 0.0490

ALA 2452 GLN 2453 0.0574

GLN 2453 ILE 2454 0.0394

ILE 2454 ILE 2455 0.0516

ILE 2455 THR 2456 0.0349

THR 2456 GLY 2457 0.0587

GLY 2457 ILE 2458 0.0212

ILE 2458 SER 2459 0.0581

SER 2459 THR 2460 0.0547

THR 2460 LYS 2461 -0.1501

LYS 2461 PRO 2462 0.0198

PRO 2462 GLY 2463 0.0268

GLY 2463 ARG 2464 0.0204

ARG 2464 HIS 2465 0.0268

HIS 2465 TRP 2466 0.0119

TRP 2466 THR 2467 0.0194

THR 2467 GLU 2468 0.0231

GLU 2468 SER 2469 0.0267

SER 2469 SER 2470 0.0063

SER 2470 TRP 2471 0.0260

TRP 2471 LEU 2472 0.0261

LEU 2472 GLN 2473 0.0029

GLN 2473 ASP 2474 0.0239

ASP 2474 ALA 2475 0.0215

ALA 2475 ARG 2476 0.0143

ARG 2476 PHE 2477 0.0786

PHE 2477 ALA 2478 0.0022

ALA 2478 THR 2479 0.0021

THR 2479 LEU 2480 0.0035

LEU 2480 ARG 2481 0.0001

ARG 2481 GLU 2482 0.0034

GLU 2482 ARG 2483 0.0017

ARG 2483 ALA 2484 0.0024

ALA 2484 ARG 2485 0.0012

ARG 2485 ASP 2486 0.0030

ASP 2486 VAL 2487 0.0035

VAL 2487 LYS 2488 0.0003

LYS 2488 GLU 2489 0.0032

GLU 2489 LEU 2490 0.0018

LEU 2490 SER 2491 0.0028

SER 2491 ASN 2492 0.0008

ASN 2492 SER 2493 0.2260

SER 2493 GLN 2494 0.0229

GLN 2494 ASN 989 -0.0022

ASN 989 LYS 990 0.0051

LYS 990 ALA 991 0.0136

ALA 991 HIS 992 0.0079

HIS 992 ARG 993 0.0108

ARG 993 GLN 994 0.0128

GLN 994 ARG 995 0.0063

ARG 995 VAL 996 0.0163

VAL 996 HIS 997 0.0046

HIS 997 PRO 998 0.0070

PRO 998 PRO 999 0.0028

PRO 999 HIS 1000 0.0173

HIS 1000 ASP 1001 0.0036

ASP 1001 LEU 1002 0.0175

LEU 1002 LEU 1003 0.0118

LEU 1003 GLY 1004 0.0177

GLY 1004 SER 1005 -0.0140

SER 1005 LEU 1006 0.0111

LEU 1006 ILE 1007 0.0157

ILE 1007 VAL 1008 0.0057

VAL 1008 GLY 1009 0.0148

GLY 1009 ARG 1010 0.0148

ARG 1010 ASP 1011 0.0104

ASP 1011 LEU 1012 0.0153

LEU 1012 ARG 1013 0.0163

ARG 1013 GLU 1014 0.0006

GLU 1014 PRO 1015 0.0162

PRO 1015 THR 1016 0.0036

THR 1016 TRP 1017 0.0153

TRP 1017 ARG 1018 0.0081

ARG 1018 HIS 1019 0.0115

HIS 1019 PHE 1020 0.0076

PHE 1020 ILE 1021 -0.1186

ILE 1021 ARG 1022 0.0121

ARG 1022 VAL 1023 0.0130

VAL 1023 GLN 1024 0.0149

GLN 1024 ASP 1025 0.0015

ASP 1025 ILE 1026 0.0164

ILE 1026 PRO 1027 0.0083

PRO 1027 TRP 1028 0.0163

TRP 1028 ILE 1029 0.0135

ILE 1029 ARG 1030 0.0045

ARG 1030 ASP 1031 0.0164

ASP 1031 HIS 1032 0.0163

HIS 1032 VAL 1033 0.0022

VAL 1033 VAL 1034 0.0144

VAL 1034 GLN 1035 0.0010

GLN 1035 SER 1036 0.0164

SER 1036 ALA 1037 -0.0545

ALA 1037 LEU 1038 0.0029

LEU 1038 VAL 1039 0.0091

VAL 1039 TYR 1040 -0.0001

TYR 1040 PRO 1041 0.0132

PRO 1041 GLY 1042 0.0124

GLY 1042 ALA 1043 0.0068

ALA 1043 GLY 1044 0.0130

GLY 1044 PHE 1045 0.0131

PHE 1045 ILE 1046 0.0084

ILE 1046 CYS 1047 0.0126

CYS 1047 MET 1048 0.0139

MET 1048 ALA 1049 0.0102

ALA 1049 MET 1050 0.0095

MET 1050 GLU 1051 0.0138

GLU 1051 ALA 1052 0.0136

ALA 1052 MET 1053 -0.0128

MET 1053 VAL 1054 0.0155

VAL 1054 GLN 1055 0.0176

GLN 1055 LEU 1056 0.0164

LEU 1056 HIS 1057 0.0114

HIS 1057 GLU 1058 0.0163

GLU 1058 LEU 1059 0.0176

LEU 1059 ARG 1060 0.0141

ARG 1060 ASP 1061 0.0137

ASP 1061 SER 1062 0.0073

SER 1062 GLN 1063 0.0175

GLN 1063 SER 1064 0.0131

SER 1064 ARG 1065 0.0151

ARG 1065 LYS 1066 0.0113

LYS 1066 VAL 1067 0.0019

VAL 1067 ALA 1068 0.0151

ALA 1068 GLY 1069 0.0063

GLY 1069 TYR 1070 0.0086

TYR 1070 ARG 1071 0.0111

ARG 1071 LEU 1072 0.0051

LEU 1072 ALA 1073 0.0114

ALA 1073 GLU 1074 0.0053

GLU 1074 VAL 1075 0.0117

VAL 1075 ASP 1076 0.0040

ASP 1076 ILE 1077 0.0091

ILE 1077 LEU 1078 0.0111

LEU 1078 ARG 1079 0.0100

ARG 1079 ALA 1080 0.0136

ALA 1080 MET 1081 0.0114

MET 1081 LEU 1082 0.0073

LEU 1082 ILE 1083 0.0120

ILE 1083 PRO 1084 0.0109

PRO 1084 ASP 1085 0.0528

ASP 1085 THR 1086 0.0148

THR 1086 SER 1087 0.0066

SER 1087 GLU 1088 0.0136

GLU 1088 GLY 1089 0.0157

GLY 1089 LEU 1090 0.0150

LEU 1090 GLU 1091 0.0054

GLU 1091 ALA 1092 0.0135

ALA 1092 HIS 1093 0.0057

HIS 1093 ILE 1094 0.0106

ILE 1094 SER 1095 0.0098

SER 1095 LEU 1096 0.0080

LEU 1096 ARG 1097 0.0142

ARG 1097 PRO 1098 0.0073

PRO 1098 CYS 1099 0.0135

CYS 1099 SER 1100 0.0136

SER 1100 THR 1101 -0.0190

THR 1101 LYS 1102 0.0119

LYS 1102 LEU 1103 0.0139

LEU 1103 LEU 1104 0.0122

LEU 1104 LEU 1105 0.0167

LEU 1105 THR 1106 0.0032

THR 1106 ASN 1107 0.0163

ASN 1107 GLU 1108 0.0163

GLU 1108 TRP 1109 -0.0000

TRP 1109 TYR 1110 0.0116

TYR 1110 ASP 1111 0.0023

ASP 1111 PHE 1112 0.0129

PHE 1112 CYS 1113 0.0049

CYS 1113 VAL 1114 0.0118

VAL 1114 SER 1115 0.0103

SER 1115 SER 1116 0.0123

SER 1116 VAL 1117 -0.0142

VAL 1117 GLY 1118 0.0013

GLY 1118 ASP 1119 0.0143

ASP 1119 ASP 1120 0.0167

ASP 1120 ASP 1121 0.0005

ASP 1121 LYS 1122 0.0166

LYS 1122 PHE 1123 0.0117

PHE 1123 VAL 1124 0.0128

VAL 1124 ASP 1125 0.0122

ASP 1125 HIS 1126 0.0158

HIS 1126 CYS 1127 0.0081

CYS 1127 ARG 1128 0.0092

ARG 1128 GLY 1129 0.0087

GLY 1129 ARG 1130 0.0010

ARG 1130 ILE 1131 0.0095

ILE 1131 THR 1132 0.0014

THR 1132 ILE 1133 0.0194

ILE 1133 GLU 1134 0.0138

GLU 1134 PHE 1135 0.0040

PHE 1135 ASP 1136 0.0137

ASP 1136 THR 1137 0.0110

THR 1137 SER 1138 0.0095

SER 1138 GLY 1139 0.0128

GLY 1139 SER 1140 0.0011

SER 1140 ALA 1141 0.0111

ALA 1141 ASP 1142 0.0026

ASP 1142 THR 1143 0.0094

THR 1143 PRO 1144 0.0073

PRO 1144 ARG 1145 0.0082

ARG 1145 THR 1146 0.0046

THR 1146 SER 1147 0.0119

SER 1147 LEU 1148 0.0031

LEU 1148 ARG 1149 -0.0842

ARG 1149 GLU 1150 0.0028

GLU 1150 ARG 1151 0.0027

ARG 1151 SER 1152 0.0034

SER 1152 ARG 1153 0.0002

ARG 1153 SER 1154 0.0034

SER 1154 THR 1155 0.0020

THR 1155 GLY 1156 0.0026

GLY 1156 LEU 1157 0.0033

LEU 1157 MET 1158 0.0007

MET 1158 ARG 1159 0.0024

ARG 1159 SER 1160 0.0020

SER 1160 VAL 1161 0.0007

VAL 1161 ASP 1162 0.0016

ASP 1162 PRO 1163 0.0013

PRO 1163 SER 1164 0.0025

SER 1164 ASN 1165 0.2850

ASN 1165 LEU 1166 0.0062

LEU 1166 TYR 1167 0.0083

TYR 1167 SER 1168 0.0002

SER 1168 PHE 1169 0.0084

PHE 1169 LEU 1170 0.0049

LEU 1170 ARG 1171 0.0074

ARG 1171 ALA 1172 0.0012

ALA 1172 GLN 1173 0.0075

GLN 1173 GLY 1174 0.0077

GLY 1174 ILE 1175 0.0009

ILE 1175 TYR 1176 0.0082

TYR 1176 HIS 1177 0.0023

HIS 1177 GLY 1178 0.0086

GLY 1178 PRO 1179 0.0066

PRO 1179 ILE 1180 0.0013

ILE 1180 PHE 1181 -0.0007

PHE 1181 GLN 1182 0.0031

GLN 1182 ASN 1183 0.0030

ASN 1183 LEU 1184 0.0040

LEU 1184 LYS 1185 0.0056

LYS 1185 THR 1186 0.0044

THR 1186 ILE 1187 0.0045

ILE 1187 SER 1188 0.0053

SER 1188 SER 1189 0.0046

SER 1189 ARG 1190 0.0048

ARG 1190 LYS 1191 0.0047

LYS 1191 ASP 1192 0.0011

ASP 1192 HIS 1193 0.0031

HIS 1193 SER 1194 0.0055

SER 1194 GLU 1195 0.0032

GLU 1195 SER 1196 0.0055

SER 1196 SER 1197 -0.0944

SER 1197 PHE 1198 0.0121

PHE 1198 VAL 1199 0.0086

VAL 1199 VAL 1200 0.0086

VAL 1200 ALA 1201 0.0087

ALA 1201 ASN 1202 0.0105

ASN 1202 THR 1203 0.0119

THR 1203 ALA 1204 0.0074

ALA 1204 SER 1205 0.0075

SER 1205 VAL 1206 0.0064

VAL 1206 MET 1207 0.0070

MET 1207 PRO 1208 0.0115

PRO 1208 ASN 1209 0.0065

ASN 1209 GLY 1210 0.0119

GLY 1210 PHE 1211 0.0076

PHE 1211 GLN 1212 0.0121

GLN 1212 SER 1213 0.0150

SER 1213 PRO 1214 0.0071

PRO 1214 HIS 1215 0.0105

HIS 1215 VAL 1216 0.0108

VAL 1216 ILE 1217 0.0014

ILE 1217 HIS 1218 0.0036

HIS 1218 PRO 1219 0.0041

PRO 1219 THR 1220 0.0082

THR 1220 THR 1221 0.0070

THR 1221 LEU 1222 0.0116

LEU 1222 ASP 1223 0.0001

ASP 1223 SER 1224 0.0115

SER 1224 ILE 1225 0.0088

ILE 1225 PHE 1226 0.0070

PHE 1226 GLN 1227 0.0048

GLN 1227 GLY 1228 0.0094

GLY 1228 ALA 1229 -0.0277

ALA 1229 TYR 1230 0.0001

TYR 1230 THR 1231 0.0048

THR 1231 ALA 1232 0.0048

ALA 1232 LEU 1233 0.0013

LEU 1233 PRO 1234 0.0014

PRO 1234 GLY 1235 0.0043

GLY 1235 ALA 1236 0.0014

ALA 1236 GLY 1237 0.0045

GLY 1237 LEU 1238 0.0012

LEU 1238 ASP 1239 0.0037

ASP 1239 GLN 1240 0.0042

GLN 1240 ASN 1241 0.0031

ASN 1241 THR 1242 0.0028

THR 1242 ALA 1243 0.0019

ALA 1243 MET 1244 0.0012

MET 1244 ILE 1245 -0.0210

ILE 1245 PRO 1246 0.0016

PRO 1246 ARG 1247 0.0114

ARG 1247 SER 1248 0.0028

SER 1248 ILE 1249 0.0046

ILE 1249 GLN 1250 0.0085

GLN 1250 GLU 1251 0.0041

GLU 1251 LEU 1252 0.0113

LEU 1252 TYR 1253 0.0033

TYR 1253 LEU 1254 0.0109

LEU 1254 SER 1255 0.0040

SER 1255 SER 1256 0.0074

SER 1256 ALA 1257 0.0116

ALA 1257 LEU 1258 0.0017

LEU 1258 THR 1259 0.0118

THR 1259 SER 1260 0.0071

SER 1260 ASP 1261 0.0017

ASP 1261 VAL 1262 0.0012

VAL 1262 GLY 1263 0.0057

GLY 1263 GLN 1264 0.0048

GLN 1264 CYS 1265 0.0055

CYS 1265 LEU 1266 0.0075

LEU 1266 VAL 1267 0.0066

VAL 1267 SER 1268 0.0069

SER 1268 ASP 1269 0.0075

ASP 1269 THR 1270 0.0048

THR 1270 SER 1271 0.0072

SER 1271 LEU 1272 0.0033

LEU 1272 ILE 1273 0.0069

ILE 1273 ARG 1274 0.0021

ARG 1274 TYR 1275 0.0010

TYR 1275 ASP 1276 0.0030

ASP 1276 GLY 1277 0.0042

GLY 1277 GLN 1278 0.0081

GLN 1278 SER 1279 0.0003

SER 1279 PHE 1280 0.0049

PHE 1280 THR 1281 0.0004

THR 1281 VAL 1282 0.0054

VAL 1282 ASN 1283 0.0007

ASN 1283 VAL 1284 0.0079

VAL 1284 ASP 1285 0.0025

ASP 1285 VAL 1286 0.0082

VAL 1286 SER 1287 0.0050

SER 1287 SER 1288 0.0080

SER 1288 LYS 1289 0.0073

LYS 1289 ALA 1290 0.0020

ALA 1290 ASP 1291 0.0069

ASP 1291 SER 1292 0.0087

SER 1292 GLU 1293 0.0127

GLU 1293 HIS 1294 0.0033

HIS 1294 THR 1295 0.0056

THR 1295 PRO 1296 0.0056

PRO 1296 VAL 1297 0.0078

VAL 1297 LEU 1298 0.0043

LEU 1298 GLU 1299 0.0072

GLU 1299 ILE 1300 0.0033

ILE 1300 LYS 1301 0.0078

LYS 1301 GLY 1302 0.0021

GLY 1302 LEU 1303 0.0067

LEU 1303 ARG 1304 0.0023

ARG 1304 ASN 1305 0.0033

ASN 1305 GLN 1306 0.0034

GLN 1306 SER 1307 0.0010

SER 1307 VAL 1308 0.0077

VAL 1308 GLY 1309 0.0115

GLY 1309 GLN 1310 0.0053

GLN 1310 MET 1311 0.0158

MET 1311 ALA 1312 0.0031

ALA 1312 PRO 1313 0.0118

PRO 1313 GLN 1314 0.0159

GLN 1314 PRO 1315 0.0036

PRO 1315 GLY 1316 0.0139

GLY 1316 ASP 1317 0.0121

ASP 1317 SER 1318 0.0096

SER 1318 SER 1319 0.0159

SER 1319 ASN 1320 0.0039

ASN 1320 ASN 1321 0.0121

ASN 1321 ASP 1322 0.0059

ASP 1322 LEU 1323 0.0149

LEU 1323 CYS 1324 0.0014

CYS 1324 PHE 1325 -0.0092

PHE 1325 LYS 1326 0.0097

LYS 1326 LEU 1327 0.0082

LEU 1327 ASP 1328 0.0228

ASP 1328 TRP 1329 0.0078

TRP 1329 ALA 1330 0.0225

ALA 1330 PRO 1331 0.0148

PRO 1331 ASP 1332 0.0226

ASP 1332 ILE 1333 0.0189

ILE 1333 SER 1334 0.0156

SER 1334 SER 1335 0.0072

SER 1335 VAL 1336 0.0208

VAL 1336 LYS 1337 0.0162

LYS 1337 GLN 1338 0.0174

GLN 1338 GLU 1339 0.0176

GLU 1339 ARG 1340 0.0204

ARG 1340 LEU 1341 0.4737

LEU 1341 LYS 1342 0.0557

LYS 1342 GLU 1343 0.0835

GLU 1343 LYS 1344 0.0954

LYS 1344 PHE 1345 0.0684

PHE 1345 GLY 1346 0.0453

GLY 1346 PHE 1347 0.1070

PHE 1347 PRO 1348 0.1108

PRO 1348 LEU 1349 0.0228

LEU 1349 ASP 1350 0.1296

ASP 1350 PRO 1351 0.0713

PRO 1351 THR 1352 0.1269

THR 1352 GLU 1353 0.1251

GLU 1353 ALA 1354 0.0831

ALA 1354 ASP 1355 0.0980

ASP 1355 ILE 1356 0.1295

ILE 1356 ILE 1357 0.0436

ILE 1357 MET 1358 0.0943

MET 1358 GLY 1359 0.1766

GLY 1359 LEU 1360 0.1916

LEU 1360 ARG 1361 0.1412

ARG 1361 GLN 1362 0.1149

GLN 1362 ALA 1363 0.1919

ALA 1363 CYS 1364 0.1890

CYS 1364 ILE 1365 0.0869

ILE 1365 HIS 1366 0.1641

HIS 1366 PHE 1367 0.1906

PHE 1367 ILE 1368 0.1734

ILE 1368 HIS 1369 0.0867

HIS 1369 ARG 1370 0.1815

ARG 1370 SER 1371 0.1911

SER 1371 LEU 1372 0.1460

LEU 1372 GLN 1373 0.0858

GLN 1373 SER 1374 0.2031

SER 1374 LEU 1375 0.2022

LEU 1375 THR 1376 0.0469

THR 1376 ALA 1377 0.1903

ALA 1377 PRO 1378 0.1987

PRO 1378 ASP 1379 0.0433

ASP 1379 ARG 1380 0.1954

ARG 1380 ASP 1381 0.1882

ASP 1381 GLN 1382 0.1391

GLN 1382 LEU 1383 0.0779

LEU 1383 ASP 1384 0.0999

ASP 1384 TRP 1385 0.1877

TRP 1385 HIS 1386 0.1013

HIS 1386 GLN 1387 0.1393

GLN 1387 LYS 1388 0.1395

LYS 1388 ARG 1389 0.0896

ARG 1389 PHE 1390 0.1910

PHE 1390 TYR 1391 0.0191

TYR 1391 ASP 1392 0.1998

ASP 1392 TRP 1393 0.0644

TRP 1393 MET 1394 0.1719

MET 1394 VAL 1395 0.0871

VAL 1395 LEU 1396 0.1322

LEU 1396 GLN 1397 0.1568

GLN 1397 ILE 1398 0.0652

ILE 1398 GLN 1399 0.1907

GLN 1399 LEU 1400 0.0395

LEU 1400 ALA 1401 0.1978

ALA 1401 GLU 1402 0.0518

GLU 1402 GLU 1403 0.1713

GLU 1403 ASP 1404 0.1056

ASP 1404 ARG 1405 0.0967

ARG 1405 LEU 1406 0.1630

LEU 1406 ALA 1407 0.1936

ALA 1407 PRO 1408 0.1838

PRO 1408 ASN 1409 0.0744

ASN 1409 SER 1410 0.2067

SER 1410 SER 1411 0.0002

SER 1411 ALA 1412 0.2066

ALA 1412 TRP 1413 0.1691

TRP 1413 LEU 1414 0.0593

LEU 1414 GLN 1415 0.1746

GLN 1415 CYS 1416 0.1344

CYS 1416 SER 1417 0.1885

SER 1417 SER 1418 0.2009

SER 1418 SER 1419 0.1454

SER 1419 ASP 1420 0.1547

ASP 1420 GLU 1421 0.2228

GLU 1421 GLN 1422 0.1739

GLN 1422 LYS 1423 0.1071

LYS 1423 LEU 1424 0.1879

LEU 1424 LEU 1425 0.1951

LEU 1425 GLU 1426 0.1414

GLU 1426 ASN 1427 0.1344

ASN 1427 VAL 1428 0.1958

VAL 1428 ARG 1429 0.1899

ARG 1429 ALA 1430 0.1014

ALA 1430 SER 1431 0.1709

SER 1431 SER 1432 0.1836

SER 1432 VAL 1433 0.1959

VAL 1433 ASN 1434 0.1294

ASN 1434 GLY 1435 0.1278

GLY 1435 GLN 1436 0.1943

GLN 1436 MET 1437 0.1481

MET 1437 VAL 1438 0.0923

VAL 1438 VAL 1439 0.1619

VAL 1439 HIS 1440 0.1886

HIS 1440 VAL 1441 0.1720

VAL 1441 GLY 1442 0.1106

GLY 1442 LYS 1443 0.1616

LYS 1443 SER 1444 0.1914

SER 1444 MET 1445 0.1837

MET 1445 LEU 1446 0.0155

LEU 1446 ALA 1447 0.1825

ALA 1447 ILE 1448 0.1221

ILE 1448 LEU 1449 0.1072

LEU 1449 ARG 1450 0.1329

ARG 1450 HIS 1451 0.1021

HIS 1451 GLU 1452 0.1922

GLU 1452 ILE 1453 0.0178

ILE 1453 ALA 1454 0.0886

ALA 1454 PRO 1455 0.1483

PRO 1455 LEU 1456 0.0172

LEU 1456 GLU 1457 0.1629

GLU 1457 LEU 1458 0.1428

LEU 1458 MET 1459 0.0925

MET 1459 LEU 1460 0.0808

LEU 1460 GLN 1461 0.1544

GLN 1461 ASP 1462 0.0932

ASP 1462 LYS 1463 0.1218

LYS 1463 LEU 1464 0.1131

LEU 1464 LEU 1465 0.1624

LEU 1465 TYR 1466 0.0019

TYR 1466 ARG 1467 0.1633

ARG 1467 TYR 1468 0.1064

TYR 1468 TYR 1469 0.1301

TYR 1469 THR 1470 0.0665

THR 1470 ASP 1471 0.1121

ASP 1471 ALA 1472 0.0555

ALA 1472 ILE 1473 0.1302

ILE 1473 LYS 1474 0.1028

LYS 1474 TRP 1475 0.1011

TRP 1475 ASP 1476 0.0389

ASP 1476 ARG 1477 0.1291

ARG 1477 SER 1478 0.1289

SER 1478 TYR 1479 0.0812

TYR 1479 GLN 1480 0.0769

GLN 1480 GLN 1481 0.1293

GLN 1481 ILE 1482 0.1276

ILE 1482 ASP 1483 0.0543

ASP 1483 GLN 1484 0.1089

GLN 1484 LEU 1485 0.1572

LEU 1485 VAL 1486 0.0607

VAL 1486 LYS 1487 0.0425

LYS 1487 LEU 1488 0.0714

LEU 1488 HIS 1489 0.0745

HIS 1489 ALA 1490 0.0527

ALA 1490 HIS 1491 0.0467

HIS 1491 LYS 1492 0.0744

LYS 1492 CYS 1493 0.0747

CYS 1493 PRO 1494 0.0697

PRO 1494 THR 1495 0.0740

THR 1495 ALA 1496 0.0115

ALA 1496 LYS 1497 0.0609

LYS 1497 ILE 1498 0.0113

ILE 1498 ILE 1499 0.0228

ILE 1499 GLU 1500 0.0201

GLU 1500 ILE 1501 0.0296

ILE 1501 GLY 1502 0.0701

GLY 1502 ALA 1503 0.0720

ALA 1503 GLY 1504 0.0676

GLY 1504 THR 1505 0.1079

THR 1505 GLY 1506 0.0384

GLY 1506 GLY 1507 0.1047

GLY 1507 CYS 1508 0.0937

CYS 1508 THR 1509 0.0562

THR 1509 ARG 1510 0.1004

ARG 1510 ALA 1511 0.1130

ALA 1511 VAL 1512 0.0984

VAL 1512 LEU 1513 0.0683

LEU 1513 ASP 1514 0.1075

ASP 1514 ALA 1515 0.1114

ALA 1515 LEU 1516 0.0853

LEU 1516 SER 1517 0.0321

SER 1517 ASN 1518 0.0453

ASN 1518 GLN 1519 0.0695

GLN 1519 GLY 1520 0.0730

GLY 1520 ILE 1521 0.0612

ILE 1521 ALA 1522 0.0479

ALA 1522 ARG 1523 0.0730

ARG 1523 CYS 1524 0.0668

CYS 1524 ALA 1525 0.0604

ALA 1525 GLN 1526 0.0294

GLN 1526 TYR 1527 0.0104

TYR 1527 ASP 1528 0.0432

ASP 1528 PHE 1529 0.0348

PHE 1529 THR 1530 0.0318

THR 1530 ASP 1531 0.0097

ASP 1531 VAL 1532 0.0424

VAL 1532 SER 1533 0.1059

SER 1533 SER 1534 0.0449

SER 1534 GLY 1535 0.0875

GLY 1535 PHE 1536 0.0853

PHE 1536 PHE 1537 0.0202

PHE 1537 GLU 1538 0.1069

GLU 1538 ALA 1539 0.1067

ALA 1539 ALA 1540 0.0906

ALA 1540 GLN 1541 0.0379

GLN 1541 GLN 1542 0.1132

GLN 1542 LYS 1543 0.1094

LYS 1543 PHE 1544 0.0607

PHE 1544 ALA 1545 0.0603

ALA 1545 ALA 1546 0.0680

ALA 1546 PHE 1547 0.1126

PHE 1547 ASP 1548 0.1133

ASP 1548 ASP 1549 -0.0708

ASP 1549 VAL 1550 0.0824

VAL 1550 ILE 1551 0.0110

ILE 1551 ARG 1552 0.0911

ARG 1552 PHE 1553 0.0163

PHE 1553 GLN 1554 0.0764

GLN 1554 LYS 1555 0.0074

LYS 1555 LEU 1556 0.0969

LEU 1556 ASP 1557 0.0189

ASP 1557 ILE 1558 0.1067

ILE 1558 GLU 1559 0.0395

GLU 1559 LYS 1560 0.0861

LYS 1560 ASP 1561 0.0481

ASP 1561 ILE 1562 0.0301

ILE 1562 GLU 1563 0.0659

GLU 1563 MET 1564 0.0717

MET 1564 GLN 1565 0.1338

GLN 1565 GLY 1566 0.0002

GLY 1566 PHE 1567 0.0989

PHE 1567 GLU 1568 0.0601

GLU 1568 CYS 1569 0.0910

CYS 1569 GLY 1570 0.0787

GLY 1570 SER 1571 0.0733

SER 1571 TYR 1572 0.0919

TYR 1572 ASP 1573 0.0933

ASP 1573 LEU 1574 0.0457

LEU 1574 VAL 1575 0.0159

VAL 1575 ILE 1576 0.0756

ILE 1576 ALA 1577 0.0019

ALA 1577 SER 1578 0.0778

SER 1578 GLN 1579 0.0008

GLN 1579 VAL 1580 0.1022

VAL 1580 LEU 1581 0.1402

LEU 1581 HIS 1582 0.0153

HIS 1582 ALA 1583 0.0972

ALA 1583 THR 1584 0.1024

THR 1584 GLY 1585 0.0719

GLY 1585 LYS 1586 0.0824

LYS 1586 MET 1587 0.0644

MET 1587 GLU 1588 0.0799

GLU 1588 HIS 1589 0.1028

HIS 1589 THR 1590 0.0999

THR 1590 MET 1591 0.0687

MET 1591 ALA 1592 0.0898

ALA 1592 ASN 1593 0.1007

ASN 1593 VAL 1594 0.0953

VAL 1594 ARG 1595 0.0727

ARG 1595 LYS 1596 0.0899

LYS 1596 LEU 1597 0.1726

LEU 1597 LEU 1598 0.0659

LEU 1598 LYS 1599 0.0253

LYS 1599 PRO 1600 0.0923

PRO 1600 GLY 1601 0.0916

GLY 1601 GLY 1602 0.0838

GLY 1602 LYS 1603 0.0641

LYS 1603 LEU 1604 0.0100

LEU 1604 LEU 1605 0.0865

LEU 1605 LEU 1606 0.0021

LEU 1606 VAL 1607 0.0671

VAL 1607 GLU 1608 0.0081

GLU 1608 THR 1609 0.0228

THR 1609 THR 1610 0.0919

THR 1610 ARG 1611 0.0384

ARG 1611 ASP 1612 0.0549

ASP 1612 GLU 1613 0.2368

GLU 1613 MET 1614 0.0405

MET 1614 ASP 1615 0.1509

ASP 1615 LEU 1616 0.1247

LEU 1616 GLN 1617 0.0768

GLN 1617 LEU 1618 0.1074

LEU 1618 VAL 1619 0.1132

VAL 1619 PHE 1620 0.1561

PHE 1620 GLY 1621 0.0644

GLY 1621 LEU 1622 0.1405

LEU 1622 LEU 1623 0.1023

LEU 1623 PRO 1624 0.1653

PRO 1624 GLY 1625 0.0198

GLY 1625 TRP 1626 0.1649

TRP 1626 TRP 1627 0.1033

TRP 1627 LEU 1628 0.1367

LEU 1628 SER 1629 0.0719

SER 1629 SER 1630 0.1178

SER 1630 GLU 1631 0.1275

GLU 1631 GLU 1632 0.0658

GLU 1632 GLU 1633 0.1084

GLU 1633 ARG 1634 0.1344

ARG 1634 GLN 1635 0.0269

GLN 1635 MET 1636 0.1303

MET 1636 SER 1637 0.0256

SER 1637 PRO 1638 0.0546

PRO 1638 SER 1639 0.0933

SER 1639 LEU 1640 0.1144

LEU 1640 SER 1641 0.1337

SER 1641 THR 1642 0.0136

THR 1642 ASN 1643 0.1320

ASN 1643 SER 1644 0.1237

SER 1644 TRP 1645 0.0541

TRP 1645 GLU 1646 0.0613

GLU 1646 LYS 1647 0.0810

LYS 1647 VAL 1648 0.0972

VAL 1648 LEU 1649 0.0094

LEU 1649 LYS 1650 0.0899

LYS 1650 LYS 1651 0.0738

LYS 1651 THR 1652 0.0846

THR 1652 GLY 1653 0.0048

GLY 1653 PHE 1654 0.0947

PHE 1654 ASP 1655 0.0881

ASP 1655 GLY 1656 0.0397

GLY 1656 LEU 1657 0.0966

LEU 1657 ASP 1658 0.0222

ASP 1658 ILE 1659 0.0829

ILE 1659 GLU 1660 0.0162

GLU 1660 LEU 1661 0.1437

LEU 1661 ARG 1662 0.0394

ARG 1662 ASP 1663 0.1146

ASP 1663 CYS 1664 0.1132

CYS 1664 ASP 1665 0.1159

ASP 1665 SER 1666 0.0038

SER 1666 ASP 1667 0.0729

ASP 1667 GLU 1668 0.0583

GLU 1668 PHE 1669 0.0979

PHE 1669 TYR 1670 0.0693

TYR 1670 SER 1671 0.1087

SER 1671 PHE 1672 0.0413

PHE 1672 SER 1673 0.0677

SER 1673 VAL 1674 0.0251

VAL 1674 MET 1675 0.1144

MET 1675 MET 1676 0.0454

MET 1676 ALA 1677 0.1672

ALA 1677 THR 1678 0.0515

THR 1678 ALA 1679 0.0707

ALA 1679 SER 1680 0.0003

SER 1680 SER 1681 0.0606

SER 1681 THR 1682 0.0078

THR 1682 ILE 1683 0.0637

ILE 1683 ALA 1684 0.0493

ALA 1684 SER 1685 0.0197

SER 1685 SER 1686 0.0755

SER 1686 SER 1687 0.0109

SER 1687 MET 1688 0.0682

MET 1688 ALA 1689 0.0536

ALA 1689 PHE 1690 0.0645

PHE 1690 ALA 1691 0.0753

ALA 1691 ILE 1692 0.0684

ILE 1692 VAL 1693 -0.0888

VAL 1693 TYR 1694 0.0708

TYR 1694 GLY 1695 0.0632

GLY 1695 GLU 1696 0.0604

GLU 1696 VAL 1697 0.0708

VAL 1697 PRO 1698 0.0432

PRO 1698 LEU 1699 0.0650

LEU 1699 PRO 1700 0.0581

PRO 1700 ASP 1701 0.0255

ASP 1701 GLN 1702 0.0656

GLN 1702 PHE 1703 0.0163

PHE 1703 LEU 1704 0.0575

LEU 1704 ASP 1705 0.0445

ASP 1705 ASP 1706 0.0337

ASP 1706 MET 1707 0.0536

MET 1707 LYS 1708 0.0308

LYS 1708 THR 1709 0.0580

THR 1709 ALA 1710 0.0025

ALA 1710 ILE 1711 0.0751

ILE 1711 SER 1712 0.0269

SER 1712 SER 1713 0.0592

SER 1713 SER 1714 0.0354

SER 1714 ALA 1715 0.0541

ALA 1715 VAL 1716 0.0257

VAL 1716 SER 1717 0.0598

SER 1717 ASP 1718 0.0695

ASP 1718 PRO 1719 0.0588

PRO 1719 VAL 1720 0.0582

VAL 1720 VAL 1721 0.0726

VAL 1721 GLY 1722 0.0753

GLY 1722 HIS 1723 0.0663

HIS 1723 LEU 1724 0.0416

LEU 1724 ASP 1725 0.0074

ASP 1725 SER 1726 0.0158

SER 1726 ILE 1727 0.0694

ILE 1727 ASP 1728 0.0703

ASP 1728 ALA 1729 0.0268

ALA 1729 THR 1730 0.0681

THR 1730 GLY 1731 0.0706

GLY 1731 LYS 1732 0.0708

LYS 1732 PHE 1733 0.0291

PHE 1733 CYS 1734 0.0691

CYS 1734 ILE 1735 0.0620

ILE 1735 PHE 1736 0.0643

PHE 1736 ILE 1737 0.0702

ILE 1737 GLU 1738 0.0568

GLU 1738 ASP 1739 0.0714

ASP 1739 PRO 1740 0.0137

PRO 1740 GLU 1741 0.1734

GLU 1741 THR 1742 0.0824

THR 1742 ASP 1743 0.0325

ASP 1743 ILE 1744 0.0664

ILE 1744 LEU 1745 0.0274

LEU 1745 SER 1746 0.0544

SER 1746 SER 1747 0.0660

SER 1747 PRO 1748 0.0368

PRO 1748 ASP 1749 0.0500

ASP 1749 GLU 1750 0.0770

GLU 1750 LYS 1751 0.0208

LYS 1751 SER 1752 0.0743

SER 1752 TYR 1753 0.0366

TYR 1753 ALA 1754 0.0521

ALA 1754 SER 1755 0.0541

SER 1755 ILE 1756 0.0345

ILE 1756 GLN 1757 0.0291

GLN 1757 LYS 1758 0.0078

LYS 1758 LEU 1759 0.0726

LEU 1759 VAL 1760 0.0248

VAL 1760 THR 1761 0.0670

THR 1761 ARG 1762 0.0106

ARG 1762 CYS 1763 0.0724

CYS 1763 LYS 1764 0.0721

LYS 1764 GLY 1765 0.0407

GLY 1765 LEU 1766 0.0678

LEU 1766 ILE 1767 0.0656

ILE 1767 TRP 1768 0.0626

TRP 1768 VAL 1769 0.0728

VAL 1769 SER 1770 0.0404

SER 1770 ARG 1771 0.0583

ARG 1771 GLY 1772 0.0035

GLY 1772 GLY 1773 -0.0354

GLY 1773 ALA 1774 0.0637

ALA 1774 MET 1775 0.0613

MET 1775 HIS 1776 0.0657

HIS 1776 GLY 1777 0.0703

GLY 1777 THR 1778 0.0536

THR 1778 ARG 1779 0.0646

ARG 1779 PRO 1780 0.0327

PRO 1780 ASN 1781 0.0508

ASN 1781 SER 1782 0.0416

SER 1782 SER 1783 0.0330

SER 1783 LEU 1784 0.0702

LEU 1784 LYS 1785 0.0298

LYS 1785 THR 1786 0.0566

THR 1786 GLY 1787 0.0263

GLY 1787 LEU 1788 0.0456

LEU 1788 LEU 1789 0.0747

LEU 1789 ARG 1790 0.0162

ARG 1790 THR 1791 0.0689

THR 1791 LEU 1792 0.0049

LEU 1792 ARG 1793 0.0680

ARG 1793 LEU 1794 0.0405

LEU 1794 GLU 1795 0.0465

GLU 1795 TYR 1796 0.0230

TYR 1796 THR 1797 0.0635

THR 1797 GLU 1798 0.0077

GLU 1798 LYS 1799 0.0627

LYS 1799 ARG 1800 0.0679

ARG 1800 PHE 1801 0.0594

PHE 1801 ILE 1802 0.0686

ILE 1802 SER 1803 0.0600

SER 1803 LEU 1804 0.0608

LEU 1804 ASP 1805 -0.0304

ASP 1805 LEU 1806 0.0545

LEU 1806 ASP 1807 0.0511

ASP 1807 SER 1808 0.0654

SER 1808 ALA 1809 0.0653

ALA 1809 ARG 1810 0.0120

ARG 1810 PRO 1811 0.0161

PRO 1811 GLN 1812 0.0572

GLN 1812 TRP 1813 0.0191

TRP 1813 ASN 1814 0.0662

ASN 1814 HIS 1815 0.0604

HIS 1815 ASP 1816 0.0080

ASP 1816 SER 1817 0.0663

SER 1817 ILE 1818 0.0205

ILE 1818 THR 1819 0.0568

THR 1819 THR 1820 0.0205

THR 1820 ILE 1821 -0.0096

ILE 1821 ASN 1822 0.0359

ASN 1822 GLU 1823 0.0053

GLU 1823 VAL 1824 0.0353

VAL 1824 LEU 1825 0.0159

LEU 1825 CYS 1826 0.0383

CYS 1826 GLY 1827 0.0031

GLY 1827 ALA 1828 0.0363

ALA 1828 LEU 1829 0.0262

LEU 1829 ALA 1830 0.0284

ALA 1830 GLN 1831 0.0163

GLN 1831 ASN 1832 0.0395

ASN 1832 ALA 1833 0.0290

ALA 1833 ASP 1834 0.0039

ASP 1834 SER 1835 0.0368

SER 1835 SER 1836 0.0292

SER 1836 ILE 1837 0.2611

ILE 1837 LYS 1838 0.0140

LYS 1838 ASP 1839 0.0331

ASP 1839 SER 1840 0.0285

SER 1840 GLU 1841 0.0301

GLU 1841 PHE 1842 0.0301

PHE 1842 ALA 1843 0.0327

ALA 1843 GLU 1844 0.0265

GLU 1844 GLN 1845 0.0240

GLN 1845 ASP 1846 0.0295

ASP 1846 GLY 1847 0.0166

GLY 1847 GLN 1848 0.0204

GLN 1848 LEU 1849 0.0329

LEU 1849 PHE 1850 0.0057

PHE 1850 VAL 1851 0.0285

VAL 1851 PRO 1852 0.0127

PRO 1852 ARG 1853 0.1163

ARG 1853 ILE 1854 0.0012

ILE 1854 SER 1855 0.0294

SER 1855 CYS 1856 0.0097

CYS 1856 ASP 1857 0.0286

ASP 1857 ILE 1858 0.0300

ILE 1858 ALA 1859 0.0298

ALA 1859 ARG 1860 0.0153

ARG 1860 ASN 1861 0.0258

ASN 1861 GLU 1862 0.0304

GLU 1862 ASP 1863 0.0244

ASP 1863 LEU 1864 0.0179

LEU 1864 SER 1865 0.0298

SER 1865 SER 1866 0.0306

SER 1866 ASP 1867 0.0002

ASP 1867 SER 1868 0.0304

SER 1868 ASN 1869 -0.1066

ASN 1869 SER 1870 0.0166

SER 1870 PRO 1871 0.0113

PRO 1871 ALA 1872 0.0132

ALA 1872 GLN 1873 0.0181

GLN 1873 MET 1874 0.0013

MET 1874 GLU 1875 0.0293

GLU 1875 PRO 1876 0.0109

PRO 1876 PHE 1877 0.0306

PHE 1877 HIS 1878 0.0251

HIS 1878 GLN 1879 0.0201

GLN 1879 PRO 1880 0.0306

PRO 1880 GLY 1881 0.0083

GLY 1881 LYS 1882 0.0244

LYS 1882 LEU 1883 0.0300

LEU 1883 LEU 1884 0.0310

LEU 1884 GLN 1885 -0.0887

GLN 1885 MET 1886 0.0204

MET 1886 GLY 1887 0.0027

GLY 1887 ILE 1888 0.0166

ILE 1888 LYS 1889 0.0130

LYS 1889 THR 1890 0.0158

THR 1890 PRO 1891 0.0206

PRO 1891 GLY 1892 0.0198

GLY 1892 LEU 1893 0.0130

LEU 1893 ILE 1894 0.0026

ILE 1894 ASP 1895 0.0191

ASP 1895 THR 1896 0.0145

THR 1896 LEU 1897 0.0125

LEU 1897 GLN 1898 0.0201

GLN 1898 PHE 1899 0.0190

PHE 1899 SER 1900 0.0137

SER 1900 LYS 1901 0.0770

LYS 1901 THR 1902 0.0256

THR 1902 ASP 1903 0.0292

ASP 1903 ALA 1904 0.0130

ALA 1904 THR 1905 0.0260

THR 1905 ASP 1906 0.0102

ASP 1906 ASN 1907 0.0261

ASN 1907 LEU 1908 0.0274

LEU 1908 PRO 1909 0.0195

PRO 1909 ASN 1910 0.0236

ASN 1910 ASP 1911 0.0292

ASP 1911 TYR 1912 0.0279

TYR 1912 ILE 1913 0.0084

ILE 1913 GLU 1914 0.0280

GLU 1914 ILE 1915 0.0228

ILE 1915 GLU 1916 0.0243

GLU 1916 PRO 1917 -0.0123

PRO 1917 LYS 1918 0.0092

LYS 1918 ALA 1919 0.0221

ALA 1919 PHE 1920 0.0049

PHE 1920 GLY 1921 0.0241

GLY 1921 LEU 1922 0.0156

LEU 1922 ASN 1923 0.0127

ASN 1923 PHE 1924 0.0157

PHE 1924 ARG 1925 0.0132

ARG 1925 ASP 1926 0.0244

ASP 1926 VAL 1927 0.0258

VAL 1927 MET 1928 0.0057

MET 1928 VAL 1929 0.0248

VAL 1929 ALA 1930 0.0232

ALA 1930 MET 1931 0.0189

MET 1931 GLY 1932 0.0089

GLY 1932 GLN 1933 0.0348

GLN 1933 LEU 1934 0.0250

LEU 1934 GLU 1935 0.0134

GLU 1935 GLU 1936 0.0138

GLU 1936 SER 1937 0.0192

SER 1937 ILE 1938 0.0089

ILE 1938 MET 1939 0.0038

MET 1939 GLY 1940 0.0041

GLY 1940 PHE 1941 0.0249

PHE 1941 GLU 1942 0.0015

GLU 1942 CYS 1943 0.0077

CYS 1943 ALA 1944 0.0034

ALA 1944 GLY 1945 0.0222

GLY 1945 VAL 1946 0.0225

VAL 1946 VAL 1947 0.0178

VAL 1947 ARG 1948 0.0247

ARG 1948 ARG 1949 0.0333

ARG 1949 VAL 1950 0.0237

VAL 1950 GLY 1951 0.0090

GLY 1951 PRO 1952 0.0260

PRO 1952 SER 1953 0.0228

SER 1953 SER 1954 0.0209

SER 1954 ALA 1955 0.0046

ALA 1955 GLY 1956 0.0263

GLY 1956 HIS 1957 0.0266

HIS 1957 ASN 1958 0.0028

ASN 1958 ILE 1959 0.0259

ILE 1959 LYS 1960 0.0180

LYS 1960 VAL 1961 0.0263

VAL 1961 GLY 1962 0.0159

GLY 1962 ASP 1963 0.0251

ASP 1963 ARG 1964 0.0264

ARG 1964 VAL 1965 -0.0220

VAL 1965 CYS 1966 0.0136

CYS 1966 ALA 1967 0.0022

ALA 1967 LEU 1968 0.0031

LEU 1968 LEU 1969 0.0212

LEU 1969 GLY 1970 0.0033

GLY 1970 GLY 1971 0.0284

GLY 1971 GLN 1972 0.0217

GLN 1972 TRP 1973 0.0164

TRP 1973 THR 1974 0.0225

THR 1974 ASN 1975 0.0044

ASN 1975 THR 1976 0.0283

THR 1976 VAL 1977 0.0215

VAL 1977 ARG 1978 0.0241

ARG 1978 VAL 1979 0.0270

VAL 1979 HIS 1980 0.0276

HIS 1980 TRP 1981 0.0554

TRP 1981 HIS 1982 0.0233

HIS 1982 SER 1983 0.0268

SER 1983 VAL 1984 0.0008

VAL 1984 ALA 1985 0.0115

ALA 1985 PRO 1986 0.0009

PRO 1986 ILE 1987 0.0203

ILE 1987 PRO 1988 0.0057

PRO 1988 GLN 1989 0.0120

GLN 1989 ALA 1990 0.0244

ALA 1990 MET 1991 0.0069

MET 1991 ASP 1992 0.0275

ASP 1992 TRP 1993 0.0099

TRP 1993 GLU 1994 0.0248

GLU 1994 THR 1995 0.0277

THR 1995 ALA 1996 0.0236

ALA 1996 ALA 1997 -0.0138

ALA 1997 SER 1998 0.0273

SER 1998 ILE 1999 0.0271

ILE 1999 PRO 2000 0.0146

PRO 2000 ILE 2001 0.0092

ILE 2001 VAL 2002 0.0280

VAL 2002 PHE 2003 0.0267

PHE 2003 VAL 2004 0.0158

VAL 2004 THR 2005 0.0145

THR 2005 ALA 2006 0.0254

ALA 2006 TYR 2007 0.0284

TYR 2007 ILE 2008 0.0057

ILE 2008 SER 2009 0.0238

SER 2009 LEU 2010 0.0226

LEU 2010 VAL 2011 0.0259

VAL 2011 LYS 2012 0.0168

LYS 2012 ILE 2013 0.0079

ILE 2013 ALA 2014 0.0272

ALA 2014 ARG 2015 0.0217

ARG 2015 MET 2016 0.0211

MET 2016 GLN 2017 0.0243

GLN 2017 ALA 2018 0.0125

ALA 2018 GLY 2019 0.0253

GLY 2019 GLU 2020 0.0137

GLU 2020 THR 2021 0.0273

THR 2021 VAL 2022 0.0276

VAL 2022 LEU 2023 0.0269

LEU 2023 ILE 2024 0.0208

ILE 2024 HIS 2025 0.0263

HIS 2025 ALA 2026 0.0150

ALA 2026 ALA 2027 0.0155

ALA 2027 SER 2028 0.0104

SER 2028 GLY 2029 0.0486

GLY 2029 GLY 2030 0.0272

GLY 2030 VAL 2031 0.0105

VAL 2031 GLY 2032 0.0292

GLY 2032 GLN 2033 0.0026

GLN 2033 ALA 2034 0.0288

ALA 2034 ALA 2035 0.0115

ALA 2035 ILE 2036 0.0203

ILE 2036 ILE 2037 0.0152

ILE 2037 LEU 2038 0.0170

LEU 2038 ALA 2039 0.0227

ALA 2039 LYS 2040 0.0076

LYS 2040 HIS 2041 0.0282

HIS 2041 VAL 2042 0.0067

VAL 2042 GLY 2043 0.0282

GLY 2043 ALA 2044 0.0137

ALA 2044 GLU 2045 0.0063

GLU 2045 ILE 2046 0.0290

ILE 2046 PHE 2047 0.0224

PHE 2047 ALA 2048 0.0279

ALA 2048 THR 2049 0.0262

THR 2049 VAL 2050 0.0203

VAL 2050 GLY 2051 0.0285

GLY 2051 THR 2052 0.0108

THR 2052 ASP 2053 0.0163

ASP 2053 GLU 2054 0.0133

GLU 2054 LYS 2055 0.0209

LYS 2055 ARG 2056 0.0287

ARG 2056 ASP 2057 0.0010

ASP 2057 LEU 2058 0.0282

LEU 2058 LEU 2059 0.0193

LEU 2059 ILE 2060 0.0237

ILE 2060 LYS 2061 -0.0019

LYS 2061 GLU 2062 0.0259

GLU 2062 TYR 2063 0.0115

TYR 2063 LYS 2064 0.0260

LYS 2064 ILE 2065 0.0009

ILE 2065 PRO 2066 0.0246

PRO 2066 ASP 2067 0.0246

ASP 2067 ASP 2068 0.0062

ASP 2068 HIS 2069 0.0247

HIS 2069 ILE 2070 0.0257

ILE 2070 PHE 2071 0.0111

PHE 2071 SER 2072 0.0245

SER 2072 SER 2073 0.0220

SER 2073 ARG 2074 0.0218

ARG 2074 ASN 2075 0.0140

ASN 2075 ALA 2076 0.0158

ALA 2076 LEU 2077 0.0093

LEU 2077 PHE 2078 0.0172

PHE 2078 ALA 2079 0.0077

ALA 2079 LYS 2080 0.0228

LYS 2080 SER 2081 0.0018

SER 2081 ILE 2082 0.0234

ILE 2082 ARG 2083 0.0078

ARG 2083 GLN 2084 0.0201

GLN 2084 ARG 2085 0.0072

ARG 2085 THR 2086 0.0179

THR 2086 ASN 2087 0.0169

ASN 2087 GLY 2088 0.0082

GLY 2088 LYS 2089 0.0230

LYS 2089 GLY 2090 0.0215

GLY 2090 VAL 2091 0.0154

VAL 2091 ASP 2092 0.0232

ASP 2092 VAL 2093 -0.0013

VAL 2093 VAL 2094 0.0187

VAL 2094 LEU 2095 0.0131

LEU 2095 ASN 2096 0.0172

ASN 2096 CYS 2097 0.0171

CYS 2097 LEU 2098 0.0170

LEU 2098 ALA 2099 0.0082

ALA 2099 GLY 2100 0.0072

GLY 2100 GLY 2101 0.0185

GLY 2101 LEU 2102 0.0058

LEU 2102 LEU 2103 0.0169

LEU 2103 GLN 2104 0.0062

GLN 2104 GLU 2105 0.0137

GLU 2105 SER 2106 0.0137

SER 2106 PHE 2107 0.0051

PHE 2107 ASP 2108 0.0167

ASP 2108 CYS 2109 0.0008

CYS 2109 LEU 2110 0.0151

LEU 2110 ALA 2111 0.0165

ALA 2111 ASP 2112 0.0037

ASP 2112 PHE 2113 0.0175

PHE 2113 GLY 2114 0.0065

GLY 2114 ARG 2115 0.0172

ARG 2115 PHE 2116 0.0170

PHE 2116 ILE 2117 0.0142

ILE 2117 GLU 2118 0.0177

GLU 2118 ILE 2119 0.0097

ILE 2119 GLY 2120 0.0176

GLY 2120 LYS 2121 0.0122

LYS 2121 ARG 2122 0.0176

ARG 2122 ASP 2123 0.0078

ASP 2123 ILE 2124 0.0134

ILE 2124 GLU 2125 0.0099

GLU 2125 LEU 2126 0.0154

LEU 2126 ASN 2127 0.0052

ASN 2127 HIS 2128 0.0153

HIS 2128 CYS 2129 0.0089

CYS 2129 LEU 2130 0.0155

LEU 2130 ASN 2131 0.0136

ASN 2131 MET 2132 0.0071

MET 2132 GLY 2133 0.0160

GLY 2133 MET 2134 0.0087

MET 2134 PHE 2135 0.0095

PHE 2135 ALA 2136 0.0115

ALA 2136 ARG 2137 0.0069

ARG 2137 SER 2138 0.0155

SER 2138 ALA 2139 0.0050

ALA 2139 THR 2140 0.0156

THR 2140 PHE 2141 0.0197

PHE 2141 THR 2142 0.0178

THR 2142 ALA 2143 0.0192

ALA 2143 VAL 2144 0.0091

VAL 2144 ASP 2145 0.0201

ASP 2145 LEU 2146 0.0098

LEU 2146 ILE 2147 0.0178

ILE 2147 ALA 2148 0.0042

ALA 2148 ILE 2149 0.0159

ILE 2149 GLY 2150 0.0134

GLY 2150 ARG 2151 0.0076

ARG 2151 ASP 2152 0.0120

ASP 2152 ARG 2153 0.0136

ARG 2153 SER 2154 0.0042

SER 2154 TYR 2155 0.0196

TYR 2155 MET 2156 0.0195

MET 2156 PHE 2157 -0.0350

PHE 2157 ALA 2158 0.0233

ALA 2158 GLU 2159 0.0285

GLU 2159 ALA 2160 0.0271

ALA 2160 LEU 2161 0.0138

LEU 2161 PRO 2162 0.0180

PRO 2162 LYS 2163 0.0281

LYS 2163 ILE 2164 0.0270

ILE 2164 MET 2165 0.0097

MET 2165 THR 2166 0.0266

THR 2166 LEU 2167 0.0284

LEU 2167 LEU 2168 0.0196

LEU 2168 GLN 2169 0.0151

GLN 2169 GLU 2170 0.0286

GLU 2170 LYS 2171 0.0281

LYS 2171 ALA 2172 0.0105

ALA 2172 ILE 2173 0.0554

ILE 2173 ARG 2174 0.0329

ARG 2174 PRO 2175 0.0277

PRO 2175 VAL 2176 0.0249

VAL 2176 THR 2177 0.0279

THR 2177 PRO 2178 0.0346

PRO 2178 ILE 2179 0.0332

ILE 2179 SER 2180 0.0328

SER 2180 ILE 2181 0.0330

ILE 2181 TYR 2182 0.0270

TYR 2182 LYS 2183 0.0347

LYS 2183 ILE 2184 0.0110

ILE 2184 GLY 2185 0.0349

GLY 2185 ASP 2186 0.0345

ASP 2186 ILE 2187 0.0154

ILE 2187 GLU 2188 0.0216

GLU 2188 THR 2189 0.0910

THR 2189 ALA 2190 0.0277

ALA 2190 PHE 2191 0.0001

PHE 2191 ARG 2192 0.0279

ARG 2192 LEU 2193 0.0149

LEU 2193 MET 2194 0.0188

MET 2194 GLN 2195 0.0089

GLN 2195 ALA 2196 0.0221

ALA 2196 GLY 2197 0.0269

GLY 2197 LYS 2198 0.0028

LYS 2198 HIS 2199 0.0222

HIS 2199 MET 2200 0.0225

MET 2200 GLY 2201 0.0278

GLY 2201 LYS 2202 0.0263

LYS 2202 ILE 2203 0.0280

ILE 2203 VAL 2204 0.0249

VAL 2204 ILE 2205 0.2340

ILE 2205 THR 2206 0.0135

THR 2206 ALA 2207 0.0113

ALA 2207 PRO 2208 0.0092

PRO 2208 GLU 2209 0.0139

GLU 2209 ASP 2210 0.0155

ASP 2210 ALA 2211 0.0118

ALA 2211 MET 2212 0.0083

MET 2212 VAL 2213 0.0063

VAL 2213 PRO 2214 0.0061

PRO 2214 VAL 2215 0.0073

VAL 2215 ILE 2216 0.0008

ILE 2216 THR 2217 0.0116

THR 2217 ARG 2218 0.0032

ARG 2218 PRO 2219 0.0079

PRO 2219 PRO 2220 0.0139

PRO 2220 LYS 2221 0.6546

LYS 2221 LEU 2222 0.1207

LEU 2222 GLN 2223 0.0767

GLN 2223 LEU 2224 0.1203

LEU 2224 ARG 2225 0.1060

ARG 2225 PRO 2226 0.0157

PRO 2226 ASP 2227 0.1172

ASP 2227 ALA 2228 0.0562

ALA 2228 SER 2229 0.1187

SER 2229 TYR 2230 0.0811

TYR 2230 LEU 2231 0.1023

LEU 2231 ILE 2232 0.1182

ILE 2232 VAL 2233 0.0934

VAL 2233 GLY 2234 0.1112

GLY 2234 GLY 2235 0.0487

GLY 2235 LEU 2236 0.0903

LEU 2236 GLY 2237 -0.0139

GLY 2237 GLY 2238 0.1182

GLY 2238 ILE 2239 0.0727

ILE 2239 GLY 2240 0.1027

GLY 2240 ARG 2241 0.0203

ARG 2241 SER 2242 0.1045

SER 2242 LEU 2243 0.0971

LEU 2243 CYS 2244 0.0358

CYS 2244 LYS 2245 0.0890

LYS 2245 ASN 2246 0.0627

ASN 2246 PHE 2247 0.1179

PHE 2247 VAL 2248 0.0034

VAL 2248 GLU 2249 0.1183

GLU 2249 ASN 2250 0.0536

ASN 2250 GLY 2251 0.0922

GLY 2251 ALA 2252 0.1168

ALA 2252 ARG 2253 0.1413

ARG 2253 SER 2254 0.1142

SER 2254 LEU 2255 0.1027

LEU 2255 VAL 2256 0.1123

VAL 2256 LEU 2257 0.1346

LEU 2257 LEU 2258 0.0832

LEU 2258 SER 2259 0.1385

SER 2259 ARG 2260 0.1296

ARG 2260 ASN 2261 0.0333

ASN 2261 ALA 2262 0.0815

ALA 2262 ASN 2263 0.0723

ASN 2263 VAL 2264 0.1379

VAL 2264 SER 2265 0.0689

SER 2265 GLN 2266 0.1064

GLN 2266 GLN 2267 0.0910

GLN 2267 SER 2268 0.1350

SER 2268 GLY 2269 0.1308

GLY 2269 GLU 2270 0.1581

GLU 2270 PHE 2271 0.0442

PHE 2271 LEU 2272 0.1654

LEU 2272 ASP 2273 0.0196

ASP 2273 GLU 2274 0.1524

GLU 2274 LEU 2275 0.0960

LEU 2275 ARG 2276 0.1032

ARG 2276 SER 2277 0.0969

SER 2277 THR 2278 0.1052

THR 2278 GLY 2279 0.1655

GLY 2279 CYS 2280 0.0336

CYS 2280 ILE 2281 0.1635

ILE 2281 VAL 2282 0.1413

VAL 2282 GLY 2283 0.1436

GLY 2283 VAL 2284 0.1579

VAL 2284 VAL 2285 0.0155

VAL 2285 ASP 2286 0.1028

ASP 2286 CYS 2287 0.0115

CYS 2287 ASP 2288 0.0369

ASP 2288 ILE 2289 0.0947

ILE 2289 SER 2290 0.0435

SER 2290 SER 2291 0.1232

SER 2291 LYS 2292 0.1223

LYS 2292 THR 2293 0.0831

THR 2293 GLN 2294 0.0549

GLN 2294 VAL 2295 0.1249

VAL 2295 GLU 2296 0.1292

GLU 2296 ALA 2297 0.0396

ALA 2297 THR 2298 0.1072

THR 2298 MET 2299 0.1191

MET 2299 LEU 2300 0.1168

LEU 2300 ARG 2301 -0.0633

ARG 2301 LEU 2302 0.1181

LEU 2302 LYS 2303 0.1139

LYS 2303 LYS 2304 0.0359

LYS 2304 ASP 2305 0.0788

ASP 2305 MET 2306 0.1104

MET 2306 LEU 2307 0.1133

LEU 2307 PRO 2308 0.0102

PRO 2308 ILE 2309 0.0810

ILE 2309 ARG 2310 0.1026

ARG 2310 GLY 2311 0.1059

GLY 2311 ILE 2312 0.1075

ILE 2312 VAL 2313 0.1172

VAL 2313 HIS 2314 0.0925

HIS 2314 ALA 2315 0.1103

ALA 2315 GLY 2316 0.1153

GLY 2316 MET 2317 0.2193

MET 2317 VAL 2318 0.0749

VAL 2318 LEU 2319 0.0832

LEU 2319 GLN 2320 0.0398

GLN 2320 ASP 2321 0.0873

ASP 2321 SER 2322 0.0134

SER 2322 VAL 2323 0.0466

VAL 2323 PHE 2324 0.0649

PHE 2324 GLU 2325 0.0433

GLU 2325 ARG 2326 0.0666

ARG 2326 MET 2327 0.0708

MET 2327 SER 2328 0.0939

SER 2328 LEU 2329 0.0961

LEU 2329 ASP 2330 0.0286

ASP 2330 ASP 2331 0.0774

ASP 2331 TYR 2332 0.0863

TYR 2332 ASN 2333 -0.0204

ASN 2333 THR 2334 0.0102

THR 2334 ALA 2335 0.0939

ALA 2335 ILE 2336 0.0700

ILE 2336 ARG 2337 0.0786

ARG 2337 PRO 2338 0.0270

PRO 2338 LYS 2339 0.0773

LYS 2339 VAL 2340 0.0332

VAL 2340 GLN 2341 0.0911

GLN 2341 GLY 2342 0.0044

GLY 2342 SER 2343 0.0931

SER 2343 TRP 2344 0.0542

TRP 2344 ASN 2345 0.0620

ASN 2345 LEU 2346 0.0460

LEU 2346 HIS 2347 0.0592

HIS 2347 SER 2348 0.0876

SER 2348 GLY 2349 -0.0415

GLY 2349 LEU 2350 0.0874

LEU 2350 SER 2351 0.0581

SER 2351 ASP 2352 0.0461

ASP 2352 CYS 2353 0.0675

CYS 2353 ASP 2354 0.0984

ASP 2354 LEU 2355 0.0983

LEU 2355 ASP 2356 0.0926

ASP 2356 PHE 2357 0.0769

PHE 2357 PHE 2358 0.0695

PHE 2358 ILE 2359 0.0978

ILE 2359 MET 2360 0.0712

MET 2360 LEU 2361 0.0962

LEU 2361 SER 2362 0.0100

SER 2362 SER 2363 0.0910

SER 2363 LEU 2364 0.0734

LEU 2364 ALA 2365 0.1657

ALA 2365 GLY 2366 0.0632

GLY 2366 VAL 2367 0.0901

VAL 2367 SER 2368 0.0900

SER 2368 GLY 2369 0.0678

GLY 2369 SER 2370 0.0774

SER 2370 ALA 2371 0.0659

ALA 2371 SER 2372 0.0902

SER 2372 GLN 2373 0.0801

GLN 2373 ALA 2374 0.0256

ALA 2374 ASN 2375 0.0818

ASN 2375 TYR 2376 0.0172

TYR 2376 THR 2377 0.0790

THR 2377 ALA 2378 0.0538

ALA 2378 GLY 2379 0.0398

GLY 2379 GLY 2380 0.0678

GLY 2380 ALA 2381 0.0015

ALA 2381 TYR 2382 0.0811

TYR 2382 GLN 2383 0.0156

GLN 2383 ASP 2384 0.0729

ASP 2384 ALA 2385 0.0337

ALA 2385 LEU 2386 0.0541

LEU 2386 ALA 2387 0.0538

ALA 2387 LYS 2388 0.0314

LYS 2388 TYR 2389 0.0744

TYR 2389 ARG 2390 0.0184

ARG 2390 ARG 2391 0.0812

ARG 2391 ALA 2392 0.0123

ALA 2392 GLN 2393 0.0736

GLN 2393 GLY 2394 0.0359

GLY 2394 LEU 2395 0.0478

LEU 2395 SER 2396 0.0433

SER 2396 ALA 2397 0.0684

ALA 2397 VAL 2398 0.0682

VAL 2398 SER 2399 0.0626

SER 2399 ILE 2400 0.0535

ILE 2400 ASP 2401 0.0506

ASP 2401 LEU 2402 0.0209

LEU 2402 GLY 2403 0.0684

GLY 2403 MET 2404 0.0426

MET 2404 VAL 2405 0.0058

VAL 2405 GLN 2406 0.0461

GLN 2406 SER 2407 0.0099

SER 2407 VAL 2408 0.0676

VAL 2408 GLY 2409 0.0466

GLY 2409 TYR 2410 0.0417

TYR 2410 VAL 2411 0.0662

VAL 2411 ALA 2412 0.0039

ALA 2412 GLU 2413 0.0602

GLU 2413 THR 2414 0.0237

THR 2414 LYS 2415 0.0661

LYS 2415 GLY 2416 0.0223

GLY 2416 VAL 2417 0.0569

VAL 2417 ALA 2418 0.0603

ALA 2418 GLU 2419 0.0558

GLU 2419 ARG 2420 0.0174

ARG 2420 LEU 2421 0.0660

LEU 2421 VAL 2422 0.0638

VAL 2422 ARG 2423 0.0299

ARG 2423 MET 2424 0.0444

MET 2424 GLY 2425 0.0633

GLY 2425 TYR 2426 0.0318

TYR 2426 SER 2427 0.0267

SER 2427 PRO 2428 0.0101

PRO 2428 ILE 2429 0.1985

ILE 2429 SER 2430 0.0026

SER 2430 GLU 2431 0.0458

GLU 2431 MET 2432 0.0537

MET 2432 GLU 2433 0.0045

GLU 2433 VAL 2434 0.0514

VAL 2434 LEU 2435 0.0333

LEU 2435 LYS 2436 0.0496

LYS 2436 ILE 2437 0.0055

ILE 2437 VAL 2438 0.0519

VAL 2438 GLU 2439 0.0407

GLU 2439 HIS 2440 0.0228

HIS 2440 ALA 2441 0.0344

ALA 2441 ILE 2442 0.0366

ILE 2442 THR 2443 0.0540

THR 2443 ASN 2444 0.0107

ASN 2444 PRO 2445 0.1279

PRO 2445 PRO 2446 0.0088

PRO 2446 PRO 2447 0.0495

PRO 2447 GLU 2448 0.0046

GLU 2448 ALA 2449 0.0478

ALA 2449 SER 2450 0.0445

SER 2450 SER 2451 0.0124

SER 2451 ALA 2452 0.0479

ALA 2452 GLN 2453 0.0554

GLN 2453 ILE 2454 0.0345

ILE 2454 ILE 2455 0.0506

ILE 2455 THR 2456 0.0304

THR 2456 GLY 2457 0.0556

GLY 2457 ILE 2458 0.0229

ILE 2458 SER 2459 0.0545

SER 2459 THR 2460 0.0524

THR 2460 LYS 2461 0.1205

LYS 2461 PRO 2462 0.0210

PRO 2462 GLY 2463 0.0262

GLY 2463 ARG 2464 0.0204

ARG 2464 HIS 2465 0.0257

HIS 2465 TRP 2466 0.0115

TRP 2466 THR 2467 0.0201

THR 2467 GLU 2468 0.0233

GLU 2468 SER 2469 0.0264

SER 2469 SER 2470 0.0048

SER 2470 TRP 2471 0.0259

TRP 2471 LEU 2472 0.0251

LEU 2472 GLN 2473 0.0044

GLN 2473 ASP 2474 0.0222

ASP 2474 ALA 2475 0.0209

ALA 2475 ARG 2476 0.0160

ARG 2476 PHE 2477 -0.0633

PHE 2477 ALA 2478 0.0018

ALA 2478 THR 2479 0.0011

THR 2479 LEU 2480 0.0025

LEU 2480 ARG 2481 0.0002

ARG 2481 GLU 2482 0.0026

GLU 2482 ARG 2483 0.0009

ARG 2483 ALA 2484 0.0022

ALA 2484 ARG 2485 0.0009

ARG 2485 ASP 2486 0.0020

ASP 2486 VAL 2487 0.0024

VAL 2487 LYS 2488 0.0002

LYS 2488 GLU 2489 0.0024

GLU 2489 LEU 2490 0.0010

LEU 2490 SER 2491 0.0024

SER 2491 ASN 2492 0.0007

ASN 2492 SER 2493 -0.2305

SER 2493 GLN 2494 0.0215

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** sdgklnrdh ***

CA strain for 22101813491974862

--- normal mode 18 ---

Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *