Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *

CA strain for 22101813491974862

--- normal mode 17 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
ASN 989 LYS 990 0.0011

LYS 990 ALA 991 0.0001

ALA 991 HIS 992 0.0010

HIS 992 ARG 993 0.0005

ARG 993 GLN 994 0.0007

GLN 994 ARG 995 0.0003

ARG 995 VAL 996 0.0011

VAL 996 HIS 997 0.0007

HIS 997 PRO 998 0.0008

PRO 998 PRO 999 0.0007

PRO 999 HIS 1000 0.0004

HIS 1000 ASP 1001 0.0010

ASP 1001 LEU 1002 -0.0000

LEU 1002 LEU 1003 0.0010

LEU 1003 GLY 1004 0.0001

GLY 1004 SER 1005 0.0837

SER 1005 LEU 1006 0.0009

LEU 1006 ILE 1007 0.0004

ILE 1007 VAL 1008 0.0010

VAL 1008 GLY 1009 0.0010

GLY 1009 ARG 1010 0.0005

ARG 1010 ASP 1011 0.0003

ASP 1011 LEU 1012 0.0005

LEU 1012 ARG 1013 0.0006

ARG 1013 GLU 1014 0.0004

GLU 1014 PRO 1015 0.0007

PRO 1015 THR 1016 0.0003

THR 1016 TRP 1017 0.0010

TRP 1017 ARG 1018 -0.0000

ARG 1018 HIS 1019 0.0008

HIS 1019 PHE 1020 0.0002

PHE 1020 ILE 1021 0.3128

ILE 1021 ARG 1022 0.0005

ARG 1022 VAL 1023 0.0012

VAL 1023 GLN 1024 0.0012

GLN 1024 ASP 1025 0.0003

ASP 1025 ILE 1026 0.0012

ILE 1026 PRO 1027 0.0010

PRO 1027 TRP 1028 0.0010

TRP 1028 ILE 1029 0.0016

ILE 1029 ARG 1030 0.0002

ARG 1030 ASP 1031 0.0011

ASP 1031 HIS 1032 0.0013

HIS 1032 VAL 1033 0.0010

VAL 1033 VAL 1034 0.0015

VAL 1034 GLN 1035 0.0009

GLN 1035 SER 1036 0.0010

SER 1036 ALA 1037 0.1153

ALA 1037 LEU 1038 0.0005

LEU 1038 VAL 1039 0.0003

VAL 1039 TYR 1040 0.0003

TYR 1040 PRO 1041 0.0005

PRO 1041 GLY 1042 0.0000

GLY 1042 ALA 1043 0.0003

ALA 1043 GLY 1044 0.0007

GLY 1044 PHE 1045 0.0001

PHE 1045 ILE 1046 0.0004

ILE 1046 CYS 1047 0.0001

CYS 1047 MET 1048 0.0002

MET 1048 ALA 1049 0.0002

ALA 1049 MET 1050 0.0003

MET 1050 GLU 1051 0.0004

GLU 1051 ALA 1052 -0.0000

ALA 1052 MET 1053 0.0371

MET 1053 VAL 1054 0.0003

VAL 1054 GLN 1055 0.0006

GLN 1055 LEU 1056 0.0008

LEU 1056 HIS 1057 0.0009

HIS 1057 GLU 1058 -0.0001

GLU 1058 LEU 1059 0.0008

LEU 1059 ARG 1060 0.0007

ARG 1060 ASP 1061 0.0009

ASP 1061 SER 1062 0.0002

SER 1062 GLN 1063 0.0006

GLN 1063 SER 1064 0.0009

SER 1064 ARG 1065 0.0000

ARG 1065 LYS 1066 0.0007

LYS 1066 VAL 1067 0.0003

VAL 1067 ALA 1068 0.0004

ALA 1068 GLY 1069 -0.0367

GLY 1069 TYR 1070 0.0004

TYR 1070 ARG 1071 0.0005

ARG 1071 LEU 1072 0.0004

LEU 1072 ALA 1073 0.0006

ALA 1073 GLU 1074 0.0005

GLU 1074 VAL 1075 0.0004

VAL 1075 ASP 1076 0.0004

ASP 1076 ILE 1077 0.0004

ILE 1077 LEU 1078 0.0002

LEU 1078 ARG 1079 0.0002

ARG 1079 ALA 1080 0.0004

ALA 1080 MET 1081 0.0003

MET 1081 LEU 1082 0.0002

LEU 1082 ILE 1083 0.0004

ILE 1083 PRO 1084 0.0002

PRO 1084 ASP 1085 -0.1289

ASP 1085 THR 1086 0.0007

THR 1086 SER 1087 0.0010

SER 1087 GLU 1088 0.0011

GLU 1088 GLY 1089 0.0006

GLY 1089 LEU 1090 0.0011

LEU 1090 GLU 1091 0.0007

GLU 1091 ALA 1092 0.0002

ALA 1092 HIS 1093 0.0009

HIS 1093 ILE 1094 0.0000

ILE 1094 SER 1095 0.0009

SER 1095 LEU 1096 0.0000

LEU 1096 ARG 1097 0.0011

ARG 1097 PRO 1098 0.0002

PRO 1098 CYS 1099 0.0011

CYS 1099 SER 1100 0.0011

SER 1100 THR 1101 -0.0619

THR 1101 LYS 1102 0.0025

LYS 1102 LEU 1103 0.0025

LEU 1103 LEU 1104 -0.0000

LEU 1104 LEU 1105 0.0025

LEU 1105 THR 1106 0.0017

THR 1106 ASN 1107 0.0014

ASN 1107 GLU 1108 0.0005

GLU 1108 TRP 1109 0.0016

TRP 1109 TYR 1110 0.0000

TYR 1110 ASP 1111 0.0015

ASP 1111 PHE 1112 0.0013

PHE 1112 CYS 1113 0.0005

CYS 1113 VAL 1114 0.0015

VAL 1114 SER 1115 0.0004

SER 1115 SER 1116 0.0003

SER 1116 VAL 1117 0.0276

VAL 1117 GLY 1118 0.0014

GLY 1118 ASP 1119 0.0006

ASP 1119 ASP 1120 0.0013

ASP 1120 ASP 1121 0.0014

ASP 1121 LYS 1122 -0.0000

LYS 1122 PHE 1123 0.0013

PHE 1123 VAL 1124 0.0007

VAL 1124 ASP 1125 0.0008

ASP 1125 HIS 1126 0.0014

HIS 1126 CYS 1127 0.0011

CYS 1127 ARG 1128 0.0011

ARG 1128 GLY 1129 0.0010

GLY 1129 ARG 1130 0.0014

ARG 1130 ILE 1131 0.0009

ILE 1131 THR 1132 0.0015

THR 1132 ILE 1133 -0.0082

ILE 1133 GLU 1134 0.0004

GLU 1134 PHE 1135 0.0007

PHE 1135 ASP 1136 0.0006

ASP 1136 THR 1137 0.0007

THR 1137 SER 1138 0.0006

SER 1138 GLY 1139 0.0007

GLY 1139 SER 1140 0.0003

SER 1140 ALA 1141 0.0001

ALA 1141 ASP 1142 0.0003

ASP 1142 THR 1143 0.0005

THR 1143 PRO 1144 0.0001

PRO 1144 ARG 1145 0.0006

ARG 1145 THR 1146 0.0002

THR 1146 SER 1147 0.0003

SER 1147 LEU 1148 0.0006

LEU 1148 ARG 1149 0.2328

ARG 1149 GLU 1150 0.0020

GLU 1150 ARG 1151 0.0048

ARG 1151 SER 1152 0.0024

SER 1152 ARG 1153 0.0044

ARG 1153 SER 1154 0.0056

SER 1154 THR 1155 0.0052

THR 1155 GLY 1156 0.0009

GLY 1156 LEU 1157 0.0004

LEU 1157 MET 1158 0.0048

MET 1158 ARG 1159 0.0006

ARG 1159 SER 1160 0.0037

SER 1160 VAL 1161 0.0041

VAL 1161 ASP 1162 0.0022

ASP 1162 PRO 1163 0.0061

PRO 1163 SER 1164 0.0006

SER 1164 ASN 1165 -0.3509

ASN 1165 LEU 1166 0.0012

LEU 1166 TYR 1167 0.0019

TYR 1167 SER 1168 0.0003

SER 1168 PHE 1169 0.0017

PHE 1169 LEU 1170 0.0011

LEU 1170 ARG 1171 0.0009

ARG 1171 ALA 1172 0.0005

ALA 1172 GLN 1173 0.0015

GLN 1173 GLY 1174 0.0017

GLY 1174 ILE 1175 0.0001

ILE 1175 TYR 1176 0.0017

TYR 1176 HIS 1177 0.0005

HIS 1177 GLY 1178 0.0019

GLY 1178 PRO 1179 0.0013

PRO 1179 ILE 1180 0.0003

ILE 1180 PHE 1181 0.0222

PHE 1181 GLN 1182 0.0010

GLN 1182 ASN 1183 0.0005

ASN 1183 LEU 1184 0.0010

LEU 1184 LYS 1185 0.0012

LYS 1185 THR 1186 0.0013

THR 1186 ILE 1187 0.0011

ILE 1187 SER 1188 0.0012

SER 1188 SER 1189 0.0012

SER 1189 ARG 1190 0.0011

ARG 1190 LYS 1191 0.0011

LYS 1191 ASP 1192 0.0004

ASP 1192 HIS 1193 0.0009

HIS 1193 SER 1194 0.0013

SER 1194 GLU 1195 0.0009

GLU 1195 SER 1196 0.0012

SER 1196 SER 1197 0.0423

SER 1197 PHE 1198 0.0011

PHE 1198 VAL 1199 0.0010

VAL 1199 VAL 1200 0.0006

VAL 1200 ALA 1201 0.0006

ALA 1201 ASN 1202 0.0011

ASN 1202 THR 1203 0.0010

THR 1203 ALA 1204 0.0007

ALA 1204 SER 1205 0.0003

SER 1205 VAL 1206 0.0008

VAL 1206 MET 1207 0.0007

MET 1207 PRO 1208 0.0010

PRO 1208 ASN 1209 0.0007

ASN 1209 GLY 1210 0.0011

GLY 1210 PHE 1211 0.0005

PHE 1211 GLN 1212 0.0010

GLN 1212 SER 1213 0.0018

SER 1213 PRO 1214 0.0004

PRO 1214 HIS 1215 0.0011

HIS 1215 VAL 1216 0.0005

VAL 1216 ILE 1217 0.0010

ILE 1217 HIS 1218 0.0003

HIS 1218 PRO 1219 0.0012

PRO 1219 THR 1220 0.0008

THR 1220 THR 1221 0.0006

THR 1221 LEU 1222 0.0007

LEU 1222 ASP 1223 0.0005

ASP 1223 SER 1224 0.0013

SER 1224 ILE 1225 0.0002

ILE 1225 PHE 1226 0.0015

PHE 1226 GLN 1227 0.0006

GLN 1227 GLY 1228 0.0010

GLY 1228 ALA 1229 -0.0176

ALA 1229 TYR 1230 0.0007

TYR 1230 THR 1231 0.0012

THR 1231 ALA 1232 0.0003

ALA 1232 LEU 1233 0.0011

LEU 1233 PRO 1234 0.0010

PRO 1234 GLY 1235 0.0000

GLY 1235 ALA 1236 0.0013

ALA 1236 GLY 1237 0.0012

GLY 1237 LEU 1238 0.0001

LEU 1238 ASP 1239 0.0010

ASP 1239 GLN 1240 0.0013

GLN 1240 ASN 1241 0.0011

ASN 1241 THR 1242 0.0011

THR 1242 ALA 1243 0.0012

ALA 1243 MET 1244 0.0003

MET 1244 ILE 1245 0.1752

ILE 1245 PRO 1246 0.0006

PRO 1246 ARG 1247 -0.0002

ARG 1247 SER 1248 0.0006

SER 1248 ILE 1249 0.0005

ILE 1249 GLN 1250 0.0003

GLN 1250 GLU 1251 0.0003

GLU 1251 LEU 1252 0.0001

LEU 1252 TYR 1253 0.0001

TYR 1253 LEU 1254 0.0002

LEU 1254 SER 1255 0.0002

SER 1255 SER 1256 0.0001

SER 1256 ALA 1257 0.0004

ALA 1257 LEU 1258 0.0004

LEU 1258 THR 1259 0.0001

THR 1259 SER 1260 0.0005

SER 1260 ASP 1261 0.0236

ASP 1261 VAL 1262 -0.0001

VAL 1262 GLY 1263 0.0006

GLY 1263 GLN 1264 0.0001

GLN 1264 CYS 1265 0.0004

CYS 1265 LEU 1266 0.0003

LEU 1266 VAL 1267 0.0006

VAL 1267 SER 1268 0.0004

SER 1268 ASP 1269 0.0003

ASP 1269 THR 1270 0.0004

THR 1270 SER 1271 0.0003

SER 1271 LEU 1272 0.0003

LEU 1272 ILE 1273 0.0002

ILE 1273 ARG 1274 0.0005

ARG 1274 TYR 1275 0.0001

TYR 1275 ASP 1276 0.0004

ASP 1276 GLY 1277 0.0101

GLY 1277 GLN 1278 0.0008

GLN 1278 SER 1279 0.0009

SER 1279 PHE 1280 0.0008

PHE 1280 THR 1281 0.0008

THR 1281 VAL 1282 0.0006

VAL 1282 ASN 1283 0.0008

ASN 1283 VAL 1284 -0.0001

VAL 1284 ASP 1285 0.0008

ASP 1285 VAL 1286 0.0002

VAL 1286 SER 1287 0.0005

SER 1287 SER 1288 0.0000

SER 1288 LYS 1289 0.0007

LYS 1289 ALA 1290 0.0005

ALA 1290 ASP 1291 0.0002

ASP 1291 SER 1292 0.0008

SER 1292 GLU 1293 0.0422

GLU 1293 HIS 1294 0.0011

HIS 1294 THR 1295 0.0010

THR 1295 PRO 1296 0.0009

PRO 1296 VAL 1297 0.0010

VAL 1297 LEU 1298 0.0005

LEU 1298 GLU 1299 -0.0001

GLU 1299 ILE 1300 0.0006

ILE 1300 LYS 1301 0.0002

LYS 1301 GLY 1302 0.0006

GLY 1302 LEU 1303 0.0009

LEU 1303 ARG 1304 0.0007

ARG 1304 ASN 1305 0.0011

ASN 1305 GLN 1306 0.0008

GLN 1306 SER 1307 0.0012

SER 1307 VAL 1308 0.0012

VAL 1308 GLY 1309 0.2332

GLY 1309 GLN 1310 0.0065

GLN 1310 MET 1311 0.0135

MET 1311 ALA 1312 0.0031

ALA 1312 PRO 1313 0.0112

PRO 1313 GLN 1314 0.0131

GLN 1314 PRO 1315 0.0039

PRO 1315 GLY 1316 0.0126

GLY 1316 ASP 1317 0.0110

ASP 1317 SER 1318 0.0058

SER 1318 SER 1319 0.0134

SER 1319 ASN 1320 0.0051

ASN 1320 ASN 1321 0.0082

ASN 1321 ASP 1322 0.0072

ASP 1322 LEU 1323 0.0125

LEU 1323 CYS 1324 0.0013

CYS 1324 PHE 1325 0.3469

PHE 1325 LYS 1326 0.0349

LYS 1326 LEU 1327 0.0274

LEU 1327 ASP 1328 0.0254

ASP 1328 TRP 1329 0.0311

TRP 1329 ALA 1330 0.0260

ALA 1330 PRO 1331 0.0362

PRO 1331 ASP 1332 0.0349

ASP 1332 ILE 1333 0.0152

ILE 1333 SER 1334 0.0239

SER 1334 SER 1335 0.0270

SER 1335 VAL 1336 0.0191

VAL 1336 LYS 1337 0.0370

LYS 1337 GLN 1338 0.0075

GLN 1338 GLU 1339 0.0370

GLU 1339 ARG 1340 0.0367

ARG 1340 LEU 1341 -0.4279

LEU 1341 LYS 1342 0.0470

LYS 1342 GLU 1343 0.1358

GLU 1343 LYS 1344 0.1366

LYS 1344 PHE 1345 0.0881

PHE 1345 GLY 1346 0.0554

GLY 1346 PHE 1347 0.0913

PHE 1347 PRO 1348 0.1227

PRO 1348 LEU 1349 0.0038

LEU 1349 ASP 1350 0.1518

ASP 1350 PRO 1351 0.0604

PRO 1351 THR 1352 0.1469

THR 1352 GLU 1353 0.1616

GLU 1353 ALA 1354 0.1289

ALA 1354 ASP 1355 0.0773

ASP 1355 ILE 1356 0.1618

ILE 1356 ILE 1357 0.2102

ILE 1357 MET 1358 0.0960

MET 1358 GLY 1359 0.1897

GLY 1359 LEU 1360 0.2207

LEU 1360 ARG 1361 0.2171

ARG 1361 GLN 1362 0.0651

GLN 1362 ALA 1363 0.2367

ALA 1363 CYS 1364 0.2296

CYS 1364 ILE 1365 0.1292

ILE 1365 HIS 1366 0.1522

HIS 1366 PHE 1367 0.2267

PHE 1367 ILE 1368 0.2371

ILE 1368 HIS 1369 0.0686

HIS 1369 ARG 1370 0.2051

ARG 1370 SER 1371 0.2155

SER 1371 LEU 1372 0.2203

LEU 1372 GLN 1373 0.0609

GLN 1373 SER 1374 0.2517

SER 1374 LEU 1375 0.2218

LEU 1375 THR 1376 0.1309

THR 1376 ALA 1377 0.2514

ALA 1377 PRO 1378 0.2434

PRO 1378 ASP 1379 0.1365

ASP 1379 ARG 1380 0.2176

ARG 1380 ASP 1381 0.2517

ASP 1381 GLN 1382 0.2032

GLN 1382 LEU 1383 0.1282

LEU 1383 ASP 1384 0.0573

ASP 1384 TRP 1385 0.1996

TRP 1385 HIS 1386 0.1977

HIS 1386 GLN 1387 0.0954

GLN 1387 LYS 1388 0.2203

LYS 1388 ARG 1389 0.1264

ARG 1389 PHE 1390 0.2400

PHE 1390 TYR 1391 0.0172

TYR 1391 ASP 1392 0.2341

ASP 1392 TRP 1393 0.1543

TRP 1393 MET 1394 0.1428

MET 1394 VAL 1395 0.1552

VAL 1395 LEU 1396 0.1412

LEU 1396 GLN 1397 0.2362

GLN 1397 ILE 1398 0.0185

ILE 1398 GLN 1399 0.2425

GLN 1399 LEU 1400 0.0952

LEU 1400 ALA 1401 0.2055

ALA 1401 GLU 1402 0.0934

GLU 1402 GLU 1403 0.1768

GLU 1403 ASP 1404 0.2019

ASP 1404 ARG 1405 0.1312

ARG 1405 LEU 1406 0.2279

LEU 1406 ALA 1407 0.2490

ALA 1407 PRO 1408 0.1997

PRO 1408 ASN 1409 0.0362

ASN 1409 SER 1410 0.2453

SER 1410 SER 1411 0.0387

SER 1411 ALA 1412 0.2323

ALA 1412 TRP 1413 0.2044

TRP 1413 LEU 1414 0.1360

LEU 1414 GLN 1415 0.1453

GLN 1415 CYS 1416 0.2192

CYS 1416 SER 1417 0.1786

SER 1417 SER 1418 0.2442

SER 1418 SER 1419 0.2325

SER 1419 ASP 1420 0.1527

ASP 1420 GLU 1421 0.2507

GLU 1421 GLN 1422 0.2340

GLN 1422 LYS 1423 0.1821

LYS 1423 LEU 1424 0.1843

LEU 1424 LEU 1425 0.2316

LEU 1425 GLU 1426 0.2249

GLU 1426 ASN 1427 0.1660

ASN 1427 VAL 1428 0.2101

VAL 1428 ARG 1429 0.2347

ARG 1429 ALA 1430 0.1966

ALA 1430 SER 1431 0.1807

SER 1431 SER 1432 0.1789

SER 1432 VAL 1433 0.2317

VAL 1433 ASN 1434 0.2105

ASN 1434 GLY 1435 0.0767

GLY 1435 GLN 1436 0.2385

GLN 1436 MET 1437 0.2188

MET 1437 VAL 1438 0.1433

VAL 1438 VAL 1439 0.1420

VAL 1439 HIS 1440 0.2297

HIS 1440 VAL 1441 0.2391

VAL 1441 GLY 1442 0.1305

GLY 1442 LYS 1443 0.1537

LYS 1443 SER 1444 0.2364

SER 1444 MET 1445 0.2390

MET 1445 LEU 1446 0.0501

LEU 1446 ALA 1447 0.2307

ALA 1447 ILE 1448 0.0776

ILE 1448 LEU 1449 0.1934

LEU 1449 ARG 1450 0.1577

ARG 1450 HIS 1451 0.1111

HIS 1451 GLU 1452 0.2274

GLU 1452 ILE 1453 0.0100

ILE 1453 ALA 1454 0.0466

ALA 1454 PRO 1455 0.1956

PRO 1455 LEU 1456 0.0164

LEU 1456 GLU 1457 0.2076

GLU 1457 LEU 1458 0.1538

LEU 1458 MET 1459 0.1051

MET 1459 LEU 1460 0.1328

LEU 1460 GLN 1461 0.1548

GLN 1461 ASP 1462 0.1804

ASP 1462 LYS 1463 0.0955

LYS 1463 LEU 1464 0.1612

LEU 1464 LEU 1465 0.1800

LEU 1465 TYR 1466 0.0458

TYR 1466 ARG 1467 0.1992

ARG 1467 TYR 1468 0.1873

TYR 1468 TYR 1469 0.0632

TYR 1469 THR 1470 0.1370

THR 1470 ASP 1471 0.1239

ASP 1471 ALA 1472 0.1124

ALA 1472 ILE 1473 0.1782

ILE 1473 LYS 1474 0.1061

LYS 1474 TRP 1475 0.1291

TRP 1475 ASP 1476 0.1027

ASP 1476 ARG 1477 0.1714

ARG 1477 SER 1478 0.1748

SER 1478 TYR 1479 0.1284

TYR 1479 GLN 1480 0.1332

GLN 1480 GLN 1481 0.1753

GLN 1481 ILE 1482 0.1658

ILE 1482 ASP 1483 0.1218

ASP 1483 GLN 1484 0.1440

GLN 1484 LEU 1485 0.1525

LEU 1485 VAL 1486 0.1058

VAL 1486 LYS 1487 0.0851

LYS 1487 LEU 1488 0.1068

LEU 1488 HIS 1489 0.1202

HIS 1489 ALA 1490 0.1018

ALA 1490 HIS 1491 0.0790

HIS 1491 LYS 1492 0.1139

LYS 1492 CYS 1493 0.1215

CYS 1493 PRO 1494 0.1205

PRO 1494 THR 1495 0.1176

THR 1495 ALA 1496 0.0378

ALA 1496 LYS 1497 0.1022

LYS 1497 ILE 1498 0.0086

ILE 1498 ILE 1499 0.0435

ILE 1499 GLU 1500 0.0175

GLU 1500 ILE 1501 0.0561

ILE 1501 GLY 1502 0.0620

GLY 1502 ALA 1503 0.1317

ALA 1503 GLY 1504 0.0660

GLY 1504 THR 1505 0.1540

THR 1505 GLY 1506 0.0467

GLY 1506 GLY 1507 0.1350

GLY 1507 CYS 1508 0.1019

CYS 1508 THR 1509 0.0780

THR 1509 ARG 1510 0.1523

ARG 1510 ALA 1511 0.1515

ALA 1511 VAL 1512 0.1039

VAL 1512 LEU 1513 0.1143

LEU 1513 ASP 1514 0.1538

ASP 1514 ALA 1515 0.1400

ALA 1515 LEU 1516 0.0960

LEU 1516 SER 1517 0.0830

SER 1517 ASN 1518 0.0830

ASN 1518 GLN 1519 0.1140

GLN 1519 GLY 1520 0.1142

GLY 1520 ILE 1521 0.0712

ILE 1521 ALA 1522 0.0990

ALA 1522 ARG 1523 0.1076

ARG 1523 CYS 1524 0.1126

CYS 1524 ALA 1525 0.0859

ALA 1525 GLN 1526 0.0432

GLN 1526 TYR 1527 0.0021

TYR 1527 ASP 1528 0.0815

ASP 1528 PHE 1529 0.0263

PHE 1529 THR 1530 0.0740

THR 1530 ASP 1531 0.0112

ASP 1531 VAL 1532 0.0839

VAL 1532 SER 1533 0.2570

SER 1533 SER 1534 0.0955

SER 1534 GLY 1535 0.0833

GLY 1535 PHE 1536 0.1274

PHE 1536 PHE 1537 0.0143

PHE 1537 GLU 1538 0.1528

GLU 1538 ALA 1539 0.1328

ALA 1539 ALA 1540 0.0998

ALA 1540 GLN 1541 0.0592

GLN 1541 GLN 1542 0.1456

GLN 1542 LYS 1543 0.1487

LYS 1543 PHE 1544 0.0463

PHE 1544 ALA 1545 0.0993

ALA 1545 ALA 1546 0.0986

ALA 1546 PHE 1547 0.1490

PHE 1547 ASP 1548 0.1528

ASP 1548 ASP 1549 0.0728

ASP 1549 VAL 1550 0.1364

VAL 1550 ILE 1551 0.0146

ILE 1551 ARG 1552 0.1402

ARG 1552 PHE 1553 0.0153

PHE 1553 GLN 1554 0.1344

GLN 1554 LYS 1555 0.0408

LYS 1555 LEU 1556 0.1473

LEU 1556 ASP 1557 0.0648

ASP 1557 ILE 1558 0.1417

ILE 1558 GLU 1559 0.0936

GLU 1559 LYS 1560 0.1121

LYS 1560 ASP 1561 0.0300

ASP 1561 ILE 1562 0.0790

ILE 1562 GLU 1563 0.0748

GLU 1563 MET 1564 0.0920

MET 1564 GLN 1565 0.1928

GLN 1565 GLY 1566 0.0127

GLY 1566 PHE 1567 0.1422

PHE 1567 GLU 1568 0.0577

GLU 1568 CYS 1569 0.1412

CYS 1569 GLY 1570 0.1172

GLY 1570 SER 1571 0.1314

SER 1571 TYR 1572 0.1108

TYR 1572 ASP 1573 0.1388

ASP 1573 LEU 1574 0.0320

LEU 1574 VAL 1575 0.0310

VAL 1575 ILE 1576 0.0746

ILE 1576 ALA 1577 0.0111

ALA 1577 SER 1578 0.0790

SER 1578 GLN 1579 0.0122

GLN 1579 VAL 1580 0.1430

VAL 1580 LEU 1581 0.1589

LEU 1581 HIS 1582 0.0237

HIS 1582 ALA 1583 0.1427

ALA 1583 THR 1584 0.1284

THR 1584 GLY 1585 0.1363

GLY 1585 LYS 1586 0.1010

LYS 1586 MET 1587 0.1168

MET 1587 GLU 1588 0.0825

GLU 1588 HIS 1589 0.1477

HIS 1589 THR 1590 0.1538

THR 1590 MET 1591 0.1041

MET 1591 ALA 1592 0.1008

ALA 1592 ASN 1593 0.1521

ASN 1593 VAL 1594 0.1519

VAL 1594 ARG 1595 0.0808

ARG 1595 LYS 1596 0.1219

LYS 1596 LEU 1597 0.0896

LEU 1597 LEU 1598 0.1089

LEU 1598 LYS 1599 0.0129

LYS 1599 PRO 1600 0.1386

PRO 1600 GLY 1601 0.1401

GLY 1601 GLY 1602 0.1097

GLY 1602 LYS 1603 0.0638

LYS 1603 LEU 1604 0.0080

LEU 1604 LEU 1605 0.1062

LEU 1605 LEU 1606 0.0039

LEU 1606 VAL 1607 0.0648

VAL 1607 GLU 1608 0.0470

GLU 1608 THR 1609 0.0199

THR 1609 THR 1610 0.1414

THR 1610 ARG 1611 0.0295

ARG 1611 ASP 1612 0.0696

ASP 1612 GLU 1613 0.1295

GLU 1613 MET 1614 0.0325

MET 1614 ASP 1615 0.2138

ASP 1615 LEU 1616 0.1037

LEU 1616 GLN 1617 0.1684

GLN 1617 LEU 1618 0.0860

LEU 1618 VAL 1619 0.1689

VAL 1619 PHE 1620 0.1542

PHE 1620 GLY 1621 0.1473

GLY 1621 LEU 1622 0.1739

LEU 1622 LEU 1623 0.0836

LEU 1623 PRO 1624 0.2133

PRO 1624 GLY 1625 0.0224

GLY 1625 TRP 1626 0.2040

TRP 1626 TRP 1627 0.1912

TRP 1627 LEU 1628 0.1222

LEU 1628 SER 1629 0.3149

SER 1629 SER 1630 0.1842

SER 1630 GLU 1631 0.1755

GLU 1631 GLU 1632 0.0912

GLU 1632 GLU 1633 0.1757

GLU 1633 ARG 1634 0.1869

ARG 1634 GLN 1635 0.0554

GLN 1635 MET 1636 0.1480

MET 1636 SER 1637 0.0871

SER 1637 PRO 1638 0.0663

PRO 1638 SER 1639 0.1477

SER 1639 LEU 1640 0.1335

LEU 1640 SER 1641 0.1855

SER 1641 THR 1642 0.0365

THR 1642 ASN 1643 0.1867

ASN 1643 SER 1644 0.1815

SER 1644 TRP 1645 0.1805

TRP 1645 GLU 1646 0.0887

GLU 1646 LYS 1647 0.1480

LYS 1647 VAL 1648 0.1521

VAL 1648 LEU 1649 0.0475

LEU 1649 LYS 1650 0.1259

LYS 1650 LYS 1651 0.1400

LYS 1651 THR 1652 0.1394

THR 1652 GLY 1653 0.0168

GLY 1653 PHE 1654 0.1514

PHE 1654 ASP 1655 0.1433

ASP 1655 GLY 1656 0.0295

GLY 1656 LEU 1657 0.1380

LEU 1657 ASP 1658 0.0737

ASP 1658 ILE 1659 0.0996

ILE 1659 GLU 1660 0.0039

GLU 1660 LEU 1661 0.1455

LEU 1661 ARG 1662 0.0136

ARG 1662 ASP 1663 0.1402

ASP 1663 CYS 1664 0.1511

CYS 1664 ASP 1665 0.1599

ASP 1665 SER 1666 0.0145

SER 1666 ASP 1667 0.1444

ASP 1667 GLU 1668 0.0404

GLU 1668 PHE 1669 0.1532

PHE 1669 TYR 1670 0.0576

TYR 1670 SER 1671 0.1599

SER 1671 PHE 1672 0.0389

PHE 1672 SER 1673 0.0515

SER 1673 VAL 1674 0.0376

VAL 1674 MET 1675 0.1359

MET 1675 MET 1676 0.0215

MET 1676 ALA 1677 0.2590

ALA 1677 THR 1678 0.0223

THR 1678 ALA 1679 0.0689

ALA 1679 SER 1680 0.0177

SER 1680 SER 1681 0.0310

SER 1681 THR 1682 0.0090

THR 1682 ILE 1683 0.0539

ILE 1683 ALA 1684 0.0266

ALA 1684 SER 1685 0.0333

SER 1685 SER 1686 0.0613

SER 1686 SER 1687 0.0048

SER 1687 MET 1688 0.0776

MET 1688 ALA 1689 0.0525

ALA 1689 PHE 1690 0.0635

PHE 1690 ALA 1691 0.0739

ALA 1691 ILE 1692 0.0645

ILE 1692 VAL 1693 0.1987

VAL 1693 TYR 1694 0.0621

TYR 1694 GLY 1695 0.0623

GLY 1695 GLU 1696 0.0471

GLU 1696 VAL 1697 0.0540

VAL 1697 PRO 1698 0.0595

PRO 1698 LEU 1699 0.0278

LEU 1699 PRO 1700 0.0629

PRO 1700 ASP 1701 0.0440

ASP 1701 GLN 1702 0.0270

GLN 1702 PHE 1703 0.0418

PHE 1703 LEU 1704 0.0300

LEU 1704 ASP 1705 0.0613

ASP 1705 ASP 1706 0.0026

ASP 1706 MET 1707 0.0627

MET 1707 LYS 1708 0.0264

LYS 1708 THR 1709 0.0945

THR 1709 ALA 1710 0.0202

ALA 1710 ILE 1711 0.0572

ILE 1711 SER 1712 0.0498

SER 1712 SER 1713 0.0230

SER 1713 SER 1714 0.0606

SER 1714 ALA 1715 0.0230

ALA 1715 VAL 1716 0.0307

VAL 1716 SER 1717 0.0369

SER 1717 ASP 1718 0.0673

ASP 1718 PRO 1719 0.0703

PRO 1719 VAL 1720 0.0272

VAL 1720 VAL 1721 0.0690

VAL 1721 GLY 1722 0.0558

GLY 1722 HIS 1723 0.0709

HIS 1723 LEU 1724 0.0654

LEU 1724 ASP 1725 0.0743

ASP 1725 SER 1726 0.0358

SER 1726 ILE 1727 0.0436

ILE 1727 ASP 1728 0.0524

ASP 1728 ALA 1729 0.0118

ALA 1729 THR 1730 0.0468

THR 1730 GLY 1731 0.0455

GLY 1731 LYS 1732 0.0425

LYS 1732 PHE 1733 0.0015

PHE 1733 CYS 1734 0.0554

CYS 1734 ILE 1735 0.0327

ILE 1735 PHE 1736 0.0557

PHE 1736 ILE 1737 0.0469

ILE 1737 GLU 1738 0.0553

GLU 1738 ASP 1739 0.0555

ASP 1739 PRO 1740 0.0066

PRO 1740 GLU 1741 0.0077

GLU 1741 THR 1742 0.0448

THR 1742 ASP 1743 0.0413

ASP 1743 ILE 1744 0.0240

ILE 1744 LEU 1745 0.0391

LEU 1745 SER 1746 0.0435

SER 1746 SER 1747 0.0202

SER 1747 PRO 1748 0.0229

PRO 1748 ASP 1749 0.0083

ASP 1749 GLU 1750 0.0376

GLU 1750 LYS 1751 0.0427

LYS 1751 SER 1752 0.0234

SER 1752 TYR 1753 0.0439

TYR 1753 ALA 1754 0.0225

ALA 1754 SER 1755 0.0563

SER 1755 ILE 1756 0.0045

ILE 1756 GLN 1757 0.0688

GLN 1757 LYS 1758 0.0244

LYS 1758 LEU 1759 0.0361

LEU 1759 VAL 1760 0.0262

VAL 1760 THR 1761 0.0312

THR 1761 ARG 1762 0.0355

ARG 1762 CYS 1763 0.0339

CYS 1763 LYS 1764 0.0480

LYS 1764 GLY 1765 0.0123

GLY 1765 LEU 1766 0.0477

LEU 1766 ILE 1767 0.0276

ILE 1767 TRP 1768 0.0529

TRP 1768 VAL 1769 0.0442

VAL 1769 SER 1770 0.0370

SER 1770 ARG 1771 0.0275

ARG 1771 GLY 1772 0.0130

GLY 1772 GLY 1773 0.1393

GLY 1773 ALA 1774 0.0238

ALA 1774 MET 1775 0.0117

MET 1775 HIS 1776 0.0330

HIS 1776 GLY 1777 0.0247

GLY 1777 THR 1778 0.0328

THR 1778 ARG 1779 0.0141

ARG 1779 PRO 1780 0.0323

PRO 1780 ASN 1781 0.0058

ASN 1781 SER 1782 0.0325

SER 1782 SER 1783 0.0219

SER 1783 LEU 1784 0.0263

LEU 1784 LYS 1785 0.0220

LYS 1785 THR 1786 0.0149

THR 1786 GLY 1787 0.0319

GLY 1787 LEU 1788 0.0047

LEU 1788 LEU 1789 0.0722

LEU 1789 ARG 1790 0.0172

ARG 1790 THR 1791 0.0333

THR 1791 LEU 1792 0.0153

LEU 1792 ARG 1793 0.0357

ARG 1793 LEU 1794 0.0456

LEU 1794 GLU 1795 0.0057

GLU 1795 TYR 1796 0.0387

TYR 1796 THR 1797 0.0292

THR 1797 GLU 1798 0.0242

GLU 1798 LYS 1799 0.0463

LYS 1799 ARG 1800 0.0289

ARG 1800 PHE 1801 0.0437

PHE 1801 ILE 1802 0.0318

ILE 1802 SER 1803 0.0391

SER 1803 LEU 1804 0.0451

LEU 1804 ASP 1805 0.0733

ASP 1805 LEU 1806 0.0574

LEU 1806 ASP 1807 0.0267

ASP 1807 SER 1808 0.0561

SER 1808 ALA 1809 0.0363

ALA 1809 ARG 1810 0.0407

ARG 1810 PRO 1811 0.0155

PRO 1811 GLN 1812 0.0208

GLN 1812 TRP 1813 0.0420

TRP 1813 ASN 1814 0.0372

ASN 1814 HIS 1815 0.0572

HIS 1815 ASP 1816 0.0206

ASP 1816 SER 1817 0.0427

SER 1817 ILE 1818 0.0311

ILE 1818 THR 1819 0.0277

THR 1819 THR 1820 0.0496

THR 1820 ILE 1821 0.0336

ILE 1821 ASN 1822 0.0488

ASN 1822 GLU 1823 0.0076

GLU 1823 VAL 1824 0.0451

VAL 1824 LEU 1825 0.0166

LEU 1825 CYS 1826 0.0352

CYS 1826 GLY 1827 0.0315

GLY 1827 ALA 1828 0.0184

ALA 1828 LEU 1829 0.0435

LEU 1829 ALA 1830 0.0149

ALA 1830 GLN 1831 0.0456

GLN 1831 ASN 1832 0.0478

ASN 1832 ALA 1833 0.0487

ALA 1833 ASP 1834 0.0051

ASP 1834 SER 1835 0.0423

SER 1835 SER 1836 0.0486

SER 1836 ILE 1837 -0.0355

ILE 1837 LYS 1838 0.0229

LYS 1838 ASP 1839 0.0379

ASP 1839 SER 1840 0.0165

SER 1840 GLU 1841 0.0319

GLU 1841 PHE 1842 0.0346

PHE 1842 ALA 1843 0.0347

ALA 1843 GLU 1844 0.0373

GLU 1844 GLN 1845 0.0148

GLN 1845 ASP 1846 0.0344

ASP 1846 GLY 1847 0.0273

GLY 1847 GLN 1848 0.0329

GLN 1848 LEU 1849 0.0299

LEU 1849 PHE 1850 0.0326

PHE 1850 VAL 1851 0.0378

VAL 1851 PRO 1852 0.0375

PRO 1852 ARG 1853 0.0451

ARG 1853 ILE 1854 0.0012

ILE 1854 SER 1855 0.0040

SER 1855 CYS 1856 -0.0001

CYS 1856 ASP 1857 0.0063

ASP 1857 ILE 1858 0.0047

ILE 1858 ALA 1859 0.0066

ALA 1859 ARG 1860 0.0073

ARG 1860 ASN 1861 0.0067

ASN 1861 GLU 1862 0.0051

GLU 1862 ASP 1863 0.0069

ASP 1863 LEU 1864 0.0074

LEU 1864 SER 1865 0.0060

SER 1865 SER 1866 0.0059

SER 1866 ASP 1867 0.0025

ASP 1867 SER 1868 0.0073

SER 1868 ASN 1869 0.1114

ASN 1869 SER 1870 0.0339

SER 1870 PRO 1871 0.0349

PRO 1871 ALA 1872 0.0275

ALA 1872 GLN 1873 0.0246

GLN 1873 MET 1874 0.0370

MET 1874 GLU 1875 0.0344

GLU 1875 PRO 1876 0.0309

PRO 1876 PHE 1877 0.0006

PHE 1877 HIS 1878 0.0374

HIS 1878 GLN 1879 0.0336

GLN 1879 PRO 1880 0.0356

PRO 1880 GLY 1881 0.0312

GLY 1881 LYS 1882 0.0379

LYS 1882 LEU 1883 0.0150

LEU 1883 LEU 1884 0.0364

LEU 1884 GLN 1885 0.0486

GLN 1885 MET 1886 0.0161

MET 1886 GLY 1887 0.0159

GLY 1887 ILE 1888 0.0162

ILE 1888 LYS 1889 0.0089

LYS 1889 THR 1890 0.0135

THR 1890 PRO 1891 0.0016

PRO 1891 GLY 1892 0.0165

GLY 1892 LEU 1893 0.0036

LEU 1893 ILE 1894 0.0160

ILE 1894 ASP 1895 0.0003

ASP 1895 THR 1896 0.0162

THR 1896 LEU 1897 0.0131

LEU 1897 GLN 1898 0.0118

GLN 1898 PHE 1899 0.0163

PHE 1899 SER 1900 0.0159

SER 1900 LYS 1901 0.0882

LYS 1901 THR 1902 0.0064

THR 1902 ASP 1903 0.0211

ASP 1903 ALA 1904 0.0195

ALA 1904 THR 1905 0.0096

THR 1905 ASP 1906 0.0217

ASP 1906 ASN 1907 0.0002

ASN 1907 LEU 1908 0.0168

LEU 1908 PRO 1909 0.0018

PRO 1909 ASN 1910 0.0126

ASN 1910 ASP 1911 0.0183

ASP 1911 TYR 1912 0.0054

TYR 1912 ILE 1913 0.0132

ILE 1913 GLU 1914 0.0007

GLU 1914 ILE 1915 0.0192

ILE 1915 GLU 1916 0.0023

GLU 1916 PRO 1917 0.0345

PRO 1917 LYS 1918 0.0144

LYS 1918 ALA 1919 0.0120

ALA 1919 PHE 1920 0.0115

PHE 1920 GLY 1921 0.0076

GLY 1921 LEU 1922 0.0157

LEU 1922 ASN 1923 0.0055

ASN 1923 PHE 1924 0.0149

PHE 1924 ARG 1925 0.0156

ARG 1925 ASP 1926 0.0009

ASP 1926 VAL 1927 0.0155

VAL 1927 MET 1928 0.0089

MET 1928 VAL 1929 0.0131

VAL 1929 ALA 1930 0.0027

ALA 1930 MET 1931 0.0143

MET 1931 GLY 1932 0.0134

GLY 1932 GLN 1933 0.0497

GLN 1933 LEU 1934 0.0128

LEU 1934 GLU 1935 0.0155

GLU 1935 GLU 1936 0.0139

GLU 1936 SER 1937 0.0008

SER 1937 ILE 1938 0.0153

ILE 1938 MET 1939 0.0141

MET 1939 GLY 1940 0.0153

GLY 1940 PHE 1941 0.0032

PHE 1941 GLU 1942 0.0153

GLU 1942 CYS 1943 0.0081

CYS 1943 ALA 1944 0.0151

ALA 1944 GLY 1945 0.0086

GLY 1945 VAL 1946 0.0148

VAL 1946 VAL 1947 0.0139

VAL 1947 ARG 1948 0.0057

ARG 1948 ARG 1949 0.0030

ARG 1949 VAL 1950 0.0010

VAL 1950 GLY 1951 0.0144

GLY 1951 PRO 1952 0.0145

PRO 1952 SER 1953 0.0030

SER 1953 SER 1954 0.0170

SER 1954 ALA 1955 0.0169

ALA 1955 GLY 1956 0.0015

GLY 1956 HIS 1957 0.0183

HIS 1957 ASN 1958 0.0134

ASN 1958 ILE 1959 0.0067

ILE 1959 LYS 1960 0.0049

LYS 1960 VAL 1961 0.0016

VAL 1961 GLY 1962 0.0154

GLY 1962 ASP 1963 0.0057

ASP 1963 ARG 1964 0.0186

ARG 1964 VAL 1965 0.0423

VAL 1965 CYS 1966 0.0166

CYS 1966 ALA 1967 0.0162

ALA 1967 LEU 1968 0.0149

LEU 1968 LEU 1969 0.0111

LEU 1969 GLY 1970 0.0168

GLY 1970 GLY 1971 0.0087

GLY 1971 GLN 1972 0.0019

GLN 1972 TRP 1973 0.0083

TRP 1973 THR 1974 0.0136

THR 1974 ASN 1975 0.0123

ASN 1975 THR 1976 0.0105

THR 1976 VAL 1977 0.0012

VAL 1977 ARG 1978 0.0096

ARG 1978 VAL 1979 0.0008

VAL 1979 HIS 1980 0.0037

HIS 1980 TRP 1981 -0.0139

TRP 1981 HIS 1982 0.0040

HIS 1982 SER 1983 0.0103

SER 1983 VAL 1984 0.0116

VAL 1984 ALA 1985 0.0136

ALA 1985 PRO 1986 0.0117

PRO 1986 ILE 1987 0.0134

ILE 1987 PRO 1988 0.0144

PRO 1988 GLN 1989 0.0041

GLN 1989 ALA 1990 0.0146

ALA 1990 MET 1991 0.0145

MET 1991 ASP 1992 0.0041

ASP 1992 TRP 1993 0.0140

TRP 1993 GLU 1994 0.0143

GLU 1994 THR 1995 0.0019

THR 1995 ALA 1996 0.0140

ALA 1996 ALA 1997 0.0321

ALA 1997 SER 1998 0.0055

SER 1998 ILE 1999 0.0038

ILE 1999 PRO 2000 0.0089

PRO 2000 ILE 2001 0.0091

ILE 2001 VAL 2002 0.0058

VAL 2002 PHE 2003 0.0045

PHE 2003 VAL 2004 0.0092

VAL 2004 THR 2005 0.0092

THR 2005 ALA 2006 0.0035

ALA 2006 TYR 2007 0.0076

TYR 2007 ILE 2008 0.0090

ILE 2008 SER 2009 0.0084

SER 2009 LEU 2010 0.0035

LEU 2010 VAL 2011 0.0085

VAL 2011 LYS 2012 0.0084

LYS 2012 ILE 2013 0.0753

ILE 2013 ALA 2014 0.0010

ALA 2014 ARG 2015 0.0032

ARG 2015 MET 2016 0.0025

MET 2016 GLN 2017 0.0009

GLN 2017 ALA 2018 0.0023

ALA 2018 GLY 2019 0.0025

GLY 2019 GLU 2020 0.0024

GLU 2020 THR 2021 0.0037

THR 2021 VAL 2022 0.0003

VAL 2022 LEU 2023 0.0030

LEU 2023 ILE 2024 0.0011

ILE 2024 HIS 2025 0.0023

HIS 2025 ALA 2026 0.0025

ALA 2026 ALA 2027 0.0024

ALA 2027 SER 2028 0.0032

SER 2028 GLY 2029 0.0029

GLY 2029 GLY 2030 0.0070

GLY 2030 VAL 2031 0.0056

VAL 2031 GLY 2032 0.0032

GLY 2032 GLN 2033 0.0071

GLN 2033 ALA 2034 0.0071

ALA 2034 ALA 2035 0.0033

ALA 2035 ILE 2036 0.0050

ILE 2036 ILE 2037 0.0069

ILE 2037 LEU 2038 0.0069

LEU 2038 ALA 2039 0.0031

ALA 2039 LYS 2040 0.0063

LYS 2040 HIS 2041 0.0072

HIS 2041 VAL 2042 0.0052

VAL 2042 GLY 2043 0.0037

GLY 2043 ALA 2044 0.0073

ALA 2044 GLU 2045 -0.0415

GLU 2045 ILE 2046 0.0034

ILE 2046 PHE 2047 0.0069

PHE 2047 ALA 2048 0.0023

ALA 2048 THR 2049 0.0052

THR 2049 VAL 2050 0.0042

VAL 2050 GLY 2051 0.0049

GLY 2051 THR 2052 0.0067

THR 2052 ASP 2053 0.0039

ASP 2053 GLU 2054 0.0042

GLU 2054 LYS 2055 0.0070

LYS 2055 ARG 2056 0.0000

ARG 2056 ASP 2057 0.0069

ASP 2057 LEU 2058 0.0045

LEU 2058 LEU 2059 0.0046

LEU 2059 ILE 2060 0.0023

ILE 2060 LYS 2061 0.0187

LYS 2061 GLU 2062 0.0040

GLU 2062 TYR 2063 0.0053

TYR 2063 LYS 2064 0.0005

LYS 2064 ILE 2065 0.0062

ILE 2065 PRO 2066 0.0020

PRO 2066 ASP 2067 0.0062

ASP 2067 ASP 2068 0.0046

ASP 2068 HIS 2069 0.0037

HIS 2069 ILE 2070 0.0020

ILE 2070 PHE 2071 0.0057

PHE 2071 SER 2072 0.0027

SER 2072 SER 2073 0.0026

SER 2073 ARG 2074 0.0058

ARG 2074 ASN 2075 0.0029

ASN 2075 ALA 2076 0.0046

ALA 2076 LEU 2077 0.0466

LEU 2077 PHE 2078 0.0036

PHE 2078 ALA 2079 0.0037

ALA 2079 LYS 2080 0.0015

LYS 2080 SER 2081 0.0032

SER 2081 ILE 2082 0.0038

ILE 2082 ARG 2083 0.0033

ARG 2083 GLN 2084 0.0015

GLN 2084 ARG 2085 0.0038

ARG 2085 THR 2086 0.0036

THR 2086 ASN 2087 0.0021

ASN 2087 GLY 2088 0.0019

GLY 2088 LYS 2089 0.0035

LYS 2089 GLY 2090 0.0010

GLY 2090 VAL 2091 0.0031

VAL 2091 ASP 2092 0.0037

ASP 2092 VAL 2093 -0.0225

VAL 2093 VAL 2094 0.0004

VAL 2094 LEU 2095 0.0010

LEU 2095 ASN 2096 0.0009

ASN 2096 CYS 2097 -0.0000

CYS 2097 LEU 2098 0.0021

LEU 2098 ALA 2099 0.0015

ALA 2099 GLY 2100 0.0022

GLY 2100 GLY 2101 0.0008

GLY 2101 LEU 2102 0.0018

LEU 2102 LEU 2103 0.0022

LEU 2103 GLN 2104 0.0015

GLN 2104 GLU 2105 0.0018

GLU 2105 SER 2106 0.0022

SER 2106 PHE 2107 0.0022

PHE 2107 ASP 2108 0.0013

ASP 2108 CYS 2109 -0.0218

CYS 2109 LEU 2110 0.0018

LEU 2110 ALA 2111 0.0001

ALA 2111 ASP 2112 0.0016

ASP 2112 PHE 2113 0.0021

PHE 2113 GLY 2114 0.0011

GLY 2114 ARG 2115 0.0010

ARG 2115 PHE 2116 0.0002

PHE 2116 ILE 2117 0.0016

ILE 2117 GLU 2118 0.0001

GLU 2118 ILE 2119 0.0013

ILE 2119 GLY 2120 0.0007

GLY 2120 LYS 2121 0.0010

LYS 2121 ARG 2122 0.0015

ARG 2122 ASP 2123 0.0015

ASP 2123 ILE 2124 0.0020

ILE 2124 GLU 2125 -0.0177

GLU 2125 LEU 2126 -0.0002

LEU 2126 ASN 2127 0.0002

ASN 2127 HIS 2128 -0.0001

HIS 2128 CYS 2129 0.0001

CYS 2129 LEU 2130 -0.0000

LEU 2130 ASN 2131 0.0001

ASN 2131 MET 2132 0.0002

MET 2132 GLY 2133 -0.0001

GLY 2133 MET 2134 -0.0000

MET 2134 PHE 2135 -0.0001

PHE 2135 ALA 2136 0.0000

ALA 2136 ARG 2137 0.0001

ARG 2137 SER 2138 0.0002

SER 2138 ALA 2139 0.0002

ALA 2139 THR 2140 0.0000

THR 2140 PHE 2141 0.0368

PHE 2141 THR 2142 0.0027

THR 2142 ALA 2143 0.0001

ALA 2143 VAL 2144 0.0046

VAL 2144 ASP 2145 0.0003

ASP 2145 LEU 2146 0.0049

LEU 2146 ILE 2147 0.0020

ILE 2147 ALA 2148 0.0037

ALA 2148 ILE 2149 0.0039

ILE 2149 GLY 2150 0.0020

GLY 2150 ARG 2151 0.0051

ARG 2151 ASP 2152 0.0018

ASP 2152 ARG 2153 0.0034

ARG 2153 SER 2154 0.0037

SER 2154 TYR 2155 0.0027

TYR 2155 MET 2156 0.0043

MET 2156 PHE 2157 0.0558

PHE 2157 ALA 2158 0.0099

ALA 2158 GLU 2159 0.0014

GLU 2159 ALA 2160 0.0100

ALA 2160 LEU 2161 0.0022

LEU 2161 PRO 2162 0.0096

PRO 2162 LYS 2163 0.0018

LYS 2163 ILE 2164 0.0086

ILE 2164 MET 2165 0.0057

MET 2165 THR 2166 0.0045

THR 2166 LEU 2167 0.0075

LEU 2167 LEU 2168 0.0032

LEU 2168 GLN 2169 0.0097

GLN 2169 GLU 2170 0.0012

GLU 2170 LYS 2171 0.0101

LYS 2171 ALA 2172 0.0034

ALA 2172 ILE 2173 0.0286

ILE 2173 ARG 2174 0.0040

ARG 2174 PRO 2175 0.0042

PRO 2175 VAL 2176 0.0143

VAL 2176 THR 2177 0.0116

THR 2177 PRO 2178 0.0034

PRO 2178 ILE 2179 0.0088

ILE 2179 SER 2180 0.0047

SER 2180 ILE 2181 0.0057

ILE 2181 TYR 2182 0.0045

TYR 2182 LYS 2183 0.0056

LYS 2183 ILE 2184 0.0142

ILE 2184 GLY 2185 0.0041

GLY 2185 ASP 2186 0.0106

ASP 2186 ILE 2187 0.0090

ILE 2187 GLU 2188 0.0142

GLU 2188 THR 2189 0.0382

THR 2189 ALA 2190 0.0039

ALA 2190 PHE 2191 0.0140

PHE 2191 ARG 2192 0.0140

ARG 2192 LEU 2193 0.0098

LEU 2193 MET 2194 0.0066

MET 2194 GLN 2195 0.0142

GLN 2195 ALA 2196 0.0144

ALA 2196 GLY 2197 0.0030

GLY 2197 LYS 2198 0.0135

LYS 2198 HIS 2199 0.0140

HIS 2199 MET 2200 0.0058

MET 2200 GLY 2201 0.0132

GLY 2201 LYS 2202 0.0088

LYS 2202 ILE 2203 0.0007

ILE 2203 VAL 2204 0.0120

VAL 2204 ILE 2205 0.0758

ILE 2205 THR 2206 0.0304

THR 2206 ALA 2207 0.0233

ALA 2207 PRO 2208 0.0252

PRO 2208 GLU 2209 0.0226

GLU 2209 ASP 2210 0.0141

ASP 2210 ALA 2211 0.0302

ALA 2211 MET 2212 0.0229

MET 2212 VAL 2213 0.0309

VAL 2213 PRO 2214 0.0299

PRO 2214 VAL 2215 0.0358

VAL 2215 ILE 2216 0.0347

ILE 2216 THR 2217 0.0331

THR 2217 ARG 2218 0.0300

ARG 2218 PRO 2219 0.0249

PRO 2219 PRO 2220 0.0289

PRO 2220 LYS 2221 0.1973

LYS 2221 LEU 2222 0.0328

LEU 2222 GLN 2223 0.0176

GLN 2223 LEU 2224 0.0340

LEU 2224 ARG 2225 0.0270

ARG 2225 PRO 2226 0.0124

PRO 2226 ASP 2227 0.0336

ASP 2227 ALA 2228 0.0056

ALA 2228 SER 2229 0.0280

SER 2229 TYR 2230 0.0176

TYR 2230 LEU 2231 0.0195

LEU 2231 ILE 2232 0.0302

ILE 2232 VAL 2233 0.0160

VAL 2233 GLY 2234 0.0341

GLY 2234 GLY 2235 0.0049

GLY 2235 LEU 2236 0.0323

LEU 2236 GLY 2237 0.0017

GLY 2237 GLY 2238 0.0319

GLY 2238 ILE 2239 0.0222

ILE 2239 GLY 2240 0.0283

GLY 2240 ARG 2241 0.0042

ARG 2241 SER 2242 0.0300

SER 2242 LEU 2243 0.0271

LEU 2243 CYS 2244 0.0105

CYS 2244 LYS 2245 0.0217

LYS 2245 ASN 2246 0.0200

ASN 2246 PHE 2247 0.0321

PHE 2247 VAL 2248 0.0005

VAL 2248 GLU 2249 0.0321

GLU 2249 ASN 2250 0.0166

ASN 2250 GLY 2251 0.0250

GLY 2251 ALA 2252 0.0309

ALA 2252 ARG 2253 -0.0761

ARG 2253 SER 2254 0.0290

SER 2254 LEU 2255 0.0223

LEU 2255 VAL 2256 0.0275

VAL 2256 LEU 2257 0.0361

LEU 2257 LEU 2258 0.0177

LEU 2258 SER 2259 0.0397

SER 2259 ARG 2260 0.0337

ARG 2260 ASN 2261 0.0163

ASN 2261 ALA 2262 0.0148

ALA 2262 ASN 2263 0.0287

ASN 2263 VAL 2264 0.0414

VAL 2264 SER 2265 0.0116

SER 2265 GLN 2266 0.0361

GLN 2266 GLN 2267 0.0278

GLN 2267 SER 2268 0.0414

SER 2268 GLY 2269 -0.0538

GLY 2269 GLU 2270 0.0502

GLU 2270 PHE 2271 0.0194

PHE 2271 LEU 2272 0.0541

LEU 2272 ASP 2273 0.0028

ASP 2273 GLU 2274 0.0510

GLU 2274 LEU 2275 0.0346

LEU 2275 ARG 2276 0.0307

ARG 2276 SER 2277 0.0281

SER 2277 THR 2278 0.0389

THR 2278 GLY 2279 0.0539

GLY 2279 CYS 2280 0.0063

CYS 2280 ILE 2281 0.0528

ILE 2281 VAL 2282 0.0406

VAL 2282 GLY 2283 0.0442

GLY 2283 VAL 2284 0.0483

VAL 2284 VAL 2285 0.2447

VAL 2285 ASP 2286 0.0215

ASP 2286 CYS 2287 0.0069

CYS 2287 ASP 2288 0.0077

ASP 2288 ILE 2289 0.0301

ILE 2289 SER 2290 0.0055

SER 2290 SER 2291 0.0345

SER 2291 LYS 2292 0.0339

LYS 2292 THR 2293 0.0269

THR 2293 GLN 2294 0.0123

GLN 2294 VAL 2295 0.0351

VAL 2295 GLU 2296 0.0347

GLU 2296 ALA 2297 0.0169

ALA 2297 THR 2298 0.0242

THR 2298 MET 2299 0.0344

MET 2299 LEU 2300 0.0329

LEU 2300 ARG 2301 0.1158

ARG 2301 LEU 2302 0.0333

LEU 2302 LYS 2303 0.0341

LYS 2303 LYS 2304 0.0143

LYS 2304 ASP 2305 0.0246

ASP 2305 MET 2306 0.0338

MET 2306 LEU 2307 0.0343

LEU 2307 PRO 2308 0.0077

PRO 2308 ILE 2309 0.0200

ILE 2309 ARG 2310 0.0328

ARG 2310 GLY 2311 0.0279

GLY 2311 ILE 2312 0.0257

ILE 2312 VAL 2313 0.0331

VAL 2313 HIS 2314 0.0195

HIS 2314 ALA 2315 0.0333

ALA 2315 GLY 2316 0.0300

GLY 2316 MET 2317 -0.0709

MET 2317 VAL 2318 0.0176

VAL 2318 LEU 2319 0.0412

LEU 2319 GLN 2320 0.0028

GLN 2320 ASP 2321 0.0475

ASP 2321 SER 2322 0.0039

SER 2322 VAL 2323 0.0389

VAL 2323 PHE 2324 0.0442

PHE 2324 GLU 2325 0.0049

GLU 2325 ARG 2326 0.0484

ARG 2326 MET 2327 0.0277

MET 2327 SER 2328 0.0436

SER 2328 LEU 2329 0.0489

LEU 2329 ASP 2330 0.0340

ASP 2330 ASP 2331 0.0363

ASP 2331 TYR 2332 0.0497

TYR 2332 ASN 2333 0.1691

ASN 2333 THR 2334 0.0107

THR 2334 ALA 2335 0.0303

ALA 2335 ILE 2336 0.0306

ILE 2336 ARG 2337 0.0278

ARG 2337 PRO 2338 0.0028

PRO 2338 LYS 2339 0.0317

LYS 2339 VAL 2340 0.0150

VAL 2340 GLN 2341 0.0325

GLN 2341 GLY 2342 0.0013

GLY 2342 SER 2343 0.0315

SER 2343 TRP 2344 0.0222

TRP 2344 ASN 2345 0.0259

ASN 2345 LEU 2346 0.0077

LEU 2346 HIS 2347 0.0288

HIS 2347 SER 2348 0.0296

SER 2348 GLY 2349 0.0888

GLY 2349 LEU 2350 0.0207

LEU 2350 SER 2351 0.0277

SER 2351 ASP 2352 0.0123

ASP 2352 CYS 2353 0.0208

CYS 2353 ASP 2354 0.0295

ASP 2354 LEU 2355 0.0331

LEU 2355 ASP 2356 0.0268

ASP 2356 PHE 2357 0.0190

PHE 2357 PHE 2358 0.0119

PHE 2358 ILE 2359 0.0320

ILE 2359 MET 2360 0.0132

MET 2360 LEU 2361 0.0337

LEU 2361 SER 2362 0.0017

SER 2362 SER 2363 0.0287

SER 2363 LEU 2364 0.0293

LEU 2364 ALA 2365 -0.0188

ALA 2365 GLY 2366 0.0395

GLY 2366 VAL 2367 0.0379

VAL 2367 SER 2368 0.0401

SER 2368 GLY 2369 0.0130

GLY 2369 SER 2370 0.0421

SER 2370 ALA 2371 0.0127

ALA 2371 SER 2372 0.0366

SER 2372 GLN 2373 0.0276

GLN 2373 ALA 2374 0.0289

ALA 2374 ASN 2375 0.0407

ASN 2375 TYR 2376 0.0011

TYR 2376 THR 2377 0.0423

THR 2377 ALA 2378 0.0322

ALA 2378 GLY 2379 0.0250

GLY 2379 GLY 2380 0.0174

GLY 2380 ALA 2381 0.0470

ALA 2381 TYR 2382 0.0295

TYR 2382 GLN 2383 0.0001

GLN 2383 ASP 2384 0.0293

ASP 2384 ALA 2385 0.0188

ALA 2385 LEU 2386 0.0218

LEU 2386 ALA 2387 0.0081

ALA 2387 LYS 2388 0.0242

LYS 2388 TYR 2389 0.0254

TYR 2389 ARG 2390 0.0061

ARG 2390 ARG 2391 0.0239

ARG 2391 ALA 2392 0.0150

ALA 2392 GLN 2393 0.0276

GLN 2393 GLY 2394 0.0023

GLY 2394 LEU 2395 0.0278

LEU 2395 SER 2396 0.0212

SER 2396 ALA 2397 0.0324

ALA 2397 VAL 2398 0.0231

VAL 2398 SER 2399 0.0158

SER 2399 ILE 2400 0.0192

ILE 2400 ASP 2401 0.0119

ASP 2401 LEU 2402 0.0138

LEU 2402 GLY 2403 0.0230

GLY 2403 MET 2404 0.0211

MET 2404 VAL 2405 0.0028

VAL 2405 GLN 2406 0.0184

GLN 2406 SER 2407 0.0081

SER 2407 VAL 2408 0.0216

VAL 2408 GLY 2409 0.0080

GLY 2409 TYR 2410 0.0055

TYR 2410 VAL 2411 0.0233

VAL 2411 ALA 2412 0.0034

ALA 2412 GLU 2413 0.0749

GLU 2413 THR 2414 0.0037

THR 2414 LYS 2415 0.0255

LYS 2415 GLY 2416 0.0158

GLY 2416 VAL 2417 0.0256

VAL 2417 ALA 2418 0.0152

ALA 2418 GLU 2419 0.0208

GLU 2419 ARG 2420 0.0053

ARG 2420 LEU 2421 0.0229

LEU 2421 VAL 2422 0.0210

VAL 2422 ARG 2423 0.0064

ARG 2423 MET 2424 0.0206

MET 2424 GLY 2425 0.0165

GLY 2425 TYR 2426 0.0138

TYR 2426 SER 2427 0.0023

SER 2427 PRO 2428 0.0131

PRO 2428 ILE 2429 -0.0554

ILE 2429 SER 2430 0.0011

SER 2430 GLU 2431 0.0156

GLU 2431 MET 2432 0.0160

MET 2432 GLU 2433 0.0055

GLU 2433 VAL 2434 0.0175

VAL 2434 LEU 2435 0.0064

LEU 2435 LYS 2436 0.0200

LYS 2436 ILE 2437 0.0014

ILE 2437 VAL 2438 0.0191

VAL 2438 GLU 2439 0.0078

GLU 2439 HIS 2440 0.0132

HIS 2440 ALA 2441 0.0104

ALA 2441 ILE 2442 0.0096

ILE 2442 THR 2443 0.0168

THR 2443 ASN 2444 0.0067

ASN 2444 PRO 2445 0.2332

PRO 2445 PRO 2446 0.0134

PRO 2446 PRO 2447 0.0242

PRO 2447 GLU 2448 0.0016

GLU 2448 ALA 2449 0.0095

ALA 2449 SER 2450 0.0198

SER 2450 SER 2451 0.0099

SER 2451 ALA 2452 0.0245

ALA 2452 GLN 2453 0.0203

GLN 2453 ILE 2454 0.0175

ILE 2454 ILE 2455 0.0173

ILE 2455 THR 2456 0.0205

THR 2456 GLY 2457 0.0234

GLY 2457 ILE 2458 0.0178

ILE 2458 SER 2459 0.0231

SER 2459 THR 2460 0.0231

THR 2460 LYS 2461 -0.0476

LYS 2461 PRO 2462 0.0060

PRO 2462 GLY 2463 0.0039

GLY 2463 ARG 2464 0.0003

ARG 2464 HIS 2465 0.0098

HIS 2465 TRP 2466 0.0102

TRP 2466 THR 2467 0.0016

THR 2467 GLU 2468 0.0086

GLU 2468 SER 2469 0.0089

SER 2469 SER 2470 0.0058

SER 2470 TRP 2471 0.0058

TRP 2471 LEU 2472 0.0054

LEU 2472 GLN 2473 0.0052

GLN 2473 ASP 2474 0.0098

ASP 2474 ALA 2475 0.0083

ALA 2475 ARG 2476 0.0045

ARG 2476 PHE 2477 0.0540

PHE 2477 ALA 2478 0.0137

ALA 2478 THR 2479 0.0083

THR 2479 LEU 2480 0.0079

LEU 2480 ARG 2481 0.0091

ARG 2481 GLU 2482 0.0087

GLU 2482 ARG 2483 0.0146

ARG 2483 ALA 2484 0.0005

ALA 2484 ARG 2485 0.0152

ARG 2485 ASP 2486 0.0058

ASP 2486 VAL 2487 0.0115

VAL 2487 LYS 2488 0.0069

LYS 2488 GLU 2489 0.0105

GLU 2489 LEU 2490 0.0111

LEU 2490 SER 2491 0.0032

SER 2491 ASN 2492 0.0148

ASN 2492 SER 2493 0.1581

SER 2493 GLN 2494 0.0305

GLN 2494 ASN 989 0.0206

ASN 989 LYS 990 0.0011

LYS 990 ALA 991 0.0002

ALA 991 HIS 992 0.0012

HIS 992 ARG 993 0.0005

ARG 993 GLN 994 0.0009

GLN 994 ARG 995 0.0006

ARG 995 VAL 996 0.0009

VAL 996 HIS 997 0.0007

HIS 997 PRO 998 0.0010

PRO 998 PRO 999 0.0009

PRO 999 HIS 1000 0.0002

HIS 1000 ASP 1001 0.0009

ASP 1001 LEU 1002 0.0004

LEU 1002 LEU 1003 0.0012

LEU 1003 GLY 1004 0.0005

GLY 1004 SER 1005 0.0885

SER 1005 LEU 1006 0.0009

LEU 1006 ILE 1007 0.0005

ILE 1007 VAL 1008 0.0008

VAL 1008 GLY 1009 0.0009

GLY 1009 ARG 1010 0.0004

ARG 1010 ASP 1011 0.0003

ASP 1011 LEU 1012 0.0005

LEU 1012 ARG 1013 0.0004

ARG 1013 GLU 1014 0.0007

GLU 1014 PRO 1015 0.0007

PRO 1015 THR 1016 0.0005

THR 1016 TRP 1017 0.0006

TRP 1017 ARG 1018 0.0003

ARG 1018 HIS 1019 0.0007

HIS 1019 PHE 1020 0.0005

PHE 1020 ILE 1021 0.3096

ILE 1021 ARG 1022 0.0005

ARG 1022 VAL 1023 0.0014

VAL 1023 GLN 1024 0.0016

GLN 1024 ASP 1025 0.0002

ASP 1025 ILE 1026 0.0015

ILE 1026 PRO 1027 0.0006

PRO 1027 TRP 1028 0.0012

TRP 1028 ILE 1029 0.0016

ILE 1029 ARG 1030 0.0002

ARG 1030 ASP 1031 0.0015

ASP 1031 HIS 1032 0.0013

HIS 1032 VAL 1033 0.0009

VAL 1033 VAL 1034 0.0015

VAL 1034 GLN 1035 0.0005

GLN 1035 SER 1036 0.0011

SER 1036 ALA 1037 0.1163

ALA 1037 LEU 1038 0.0006

LEU 1038 VAL 1039 0.0004

VAL 1039 TYR 1040 0.0004

TYR 1040 PRO 1041 0.0004

PRO 1041 GLY 1042 0.0001

GLY 1042 ALA 1043 0.0005

ALA 1043 GLY 1044 0.0007

GLY 1044 PHE 1045 -0.0001

PHE 1045 ILE 1046 0.0005

ILE 1046 CYS 1047 0.0002

CYS 1047 MET 1048 0.0003

MET 1048 ALA 1049 0.0003

ALA 1049 MET 1050 0.0004

MET 1050 GLU 1051 0.0006

GLU 1051 ALA 1052 0.0002

ALA 1052 MET 1053 0.0346

MET 1053 VAL 1054 0.0004

VAL 1054 GLN 1055 0.0007

GLN 1055 LEU 1056 0.0012

LEU 1056 HIS 1057 0.0010

HIS 1057 GLU 1058 0.0001

GLU 1058 LEU 1059 0.0010

LEU 1059 ARG 1060 0.0009

ARG 1060 ASP 1061 0.0011

ASP 1061 SER 1062 0.0003

SER 1062 GLN 1063 0.0010

GLN 1063 SER 1064 0.0009

SER 1064 ARG 1065 0.0000

ARG 1065 LYS 1066 0.0009

LYS 1066 VAL 1067 0.0003

VAL 1067 ALA 1068 0.0004

ALA 1068 GLY 1069 -0.0396

GLY 1069 TYR 1070 0.0005

TYR 1070 ARG 1071 0.0005

ARG 1071 LEU 1072 0.0005

LEU 1072 ALA 1073 0.0004

ALA 1073 GLU 1074 0.0006

GLU 1074 VAL 1075 0.0006

VAL 1075 ASP 1076 0.0005

ASP 1076 ILE 1077 0.0005

ILE 1077 LEU 1078 0.0003

LEU 1078 ARG 1079 0.0003

ARG 1079 ALA 1080 0.0007

ALA 1080 MET 1081 0.0001

MET 1081 LEU 1082 0.0005

LEU 1082 ILE 1083 0.0005

ILE 1083 PRO 1084 0.0002

PRO 1084 ASP 1085 -0.1283

ASP 1085 THR 1086 0.0006

THR 1086 SER 1087 0.0010

SER 1087 GLU 1088 0.0011

GLU 1088 GLY 1089 0.0002

GLY 1089 LEU 1090 0.0010

LEU 1090 GLU 1091 0.0011

GLU 1091 ALA 1092 0.0004

ALA 1092 HIS 1093 0.0009

HIS 1093 ILE 1094 0.0003

ILE 1094 SER 1095 0.0010

SER 1095 LEU 1096 0.0002

LEU 1096 ARG 1097 0.0010

ARG 1097 PRO 1098 0.0003

PRO 1098 CYS 1099 0.0010

CYS 1099 SER 1100 0.0010

SER 1100 THR 1101 -0.0560

THR 1101 LYS 1102 0.0027

LYS 1102 LEU 1103 0.0026

LEU 1103 LEU 1104 0.0001

LEU 1104 LEU 1105 0.0025

LEU 1105 THR 1106 0.0018

THR 1106 ASN 1107 0.0016

ASN 1107 GLU 1108 0.0005

GLU 1108 TRP 1109 0.0019

TRP 1109 TYR 1110 0.0000

TYR 1110 ASP 1111 0.0019

ASP 1111 PHE 1112 0.0015

PHE 1112 CYS 1113 0.0006

CYS 1113 VAL 1114 0.0017

VAL 1114 SER 1115 0.0003

SER 1115 SER 1116 0.0004

SER 1116 VAL 1117 0.0305

VAL 1117 GLY 1118 0.0016

GLY 1118 ASP 1119 0.0008

ASP 1119 ASP 1120 0.0016

ASP 1120 ASP 1121 0.0016

ASP 1121 LYS 1122 -0.0000

LYS 1122 PHE 1123 0.0014

PHE 1123 VAL 1124 0.0007

VAL 1124 ASP 1125 0.0011

ASP 1125 HIS 1126 0.0015

HIS 1126 CYS 1127 0.0015

CYS 1127 ARG 1128 0.0013

ARG 1128 GLY 1129 0.0013

GLY 1129 ARG 1130 0.0017

ARG 1130 ILE 1131 0.0011

ILE 1131 THR 1132 0.0017

THR 1132 ILE 1133 -0.0097

ILE 1133 GLU 1134 0.0005

GLU 1134 PHE 1135 0.0006

PHE 1135 ASP 1136 0.0004

ASP 1136 THR 1137 0.0007

THR 1137 SER 1138 0.0006

SER 1138 GLY 1139 0.0006

GLY 1139 SER 1140 0.0003

SER 1140 ALA 1141 0.0000

ALA 1141 ASP 1142 0.0005

ASP 1142 THR 1143 0.0004

THR 1143 PRO 1144 0.0000

PRO 1144 ARG 1145 0.0007

ARG 1145 THR 1146 0.0001

THR 1146 SER 1147 0.0004

SER 1147 LEU 1148 0.0004

LEU 1148 ARG 1149 0.2337

ARG 1149 GLU 1150 0.0023

GLU 1150 ARG 1151 0.0050

ARG 1151 SER 1152 0.0022

SER 1152 ARG 1153 0.0049

ARG 1153 SER 1154 0.0058

SER 1154 THR 1155 0.0049

THR 1155 GLY 1156 0.0009

GLY 1156 LEU 1157 0.0005

LEU 1157 MET 1158 0.0050

MET 1158 ARG 1159 0.0006

ARG 1159 SER 1160 0.0043

SER 1160 VAL 1161 0.0043

VAL 1161 ASP 1162 0.0027

ASP 1162 PRO 1163 0.0062

PRO 1163 SER 1164 0.0005

SER 1164 ASN 1165 -0.3498

ASN 1165 LEU 1166 0.0013

LEU 1166 TYR 1167 0.0020

TYR 1167 SER 1168 0.0000

SER 1168 PHE 1169 0.0018

PHE 1169 LEU 1170 0.0013

LEU 1170 ARG 1171 0.0014

ARG 1171 ALA 1172 0.0005

ALA 1172 GLN 1173 0.0018

GLN 1173 GLY 1174 0.0020

GLY 1174 ILE 1175 0.0002

ILE 1175 TYR 1176 0.0023

TYR 1176 HIS 1177 0.0006

HIS 1177 GLY 1178 0.0021

GLY 1178 PRO 1179 0.0016

PRO 1179 ILE 1180 0.0005

ILE 1180 PHE 1181 0.0222

PHE 1181 GLN 1182 0.0012

GLN 1182 ASN 1183 0.0005

ASN 1183 LEU 1184 0.0013

LEU 1184 LYS 1185 0.0013

LYS 1185 THR 1186 0.0013

THR 1186 ILE 1187 0.0014

ILE 1187 SER 1188 0.0014

SER 1188 SER 1189 0.0015

SER 1189 ARG 1190 0.0013

ARG 1190 LYS 1191 0.0014

LYS 1191 ASP 1192 0.0002

ASP 1192 HIS 1193 0.0012

HIS 1193 SER 1194 0.0013

SER 1194 GLU 1195 0.0012

GLU 1195 SER 1196 0.0012

SER 1196 SER 1197 0.0438

SER 1197 PHE 1198 0.0013

PHE 1198 VAL 1199 0.0010

VAL 1199 VAL 1200 0.0007

VAL 1200 ALA 1201 0.0009

ALA 1201 ASN 1202 0.0012

ASN 1202 THR 1203 0.0014

THR 1203 ALA 1204 0.0010

ALA 1204 SER 1205 0.0006

SER 1205 VAL 1206 0.0007

VAL 1206 MET 1207 0.0005

MET 1207 PRO 1208 0.0011

PRO 1208 ASN 1209 0.0011

ASN 1209 GLY 1210 0.0013

GLY 1210 PHE 1211 0.0006

PHE 1211 GLN 1212 0.0012

GLN 1212 SER 1213 0.0016

SER 1213 PRO 1214 0.0006

PRO 1214 HIS 1215 0.0013

HIS 1215 VAL 1216 0.0009

VAL 1216 ILE 1217 0.0008

ILE 1217 HIS 1218 0.0003

HIS 1218 PRO 1219 0.0012

PRO 1219 THR 1220 0.0007

THR 1220 THR 1221 0.0006

THR 1221 LEU 1222 0.0008

LEU 1222 ASP 1223 0.0006

ASP 1223 SER 1224 0.0014

SER 1224 ILE 1225 0.0000

ILE 1225 PHE 1226 0.0015

PHE 1226 GLN 1227 0.0003

GLN 1227 GLY 1228 0.0010

GLY 1228 ALA 1229 -0.0172

ALA 1229 TYR 1230 0.0006

TYR 1230 THR 1231 0.0012

THR 1231 ALA 1232 0.0003

ALA 1232 LEU 1233 0.0015

LEU 1233 PRO 1234 0.0012

PRO 1234 GLY 1235 0.0001

GLY 1235 ALA 1236 0.0014

ALA 1236 GLY 1237 0.0015

GLY 1237 LEU 1238 0.0004

LEU 1238 ASP 1239 0.0013

ASP 1239 GLN 1240 0.0012

GLN 1240 ASN 1241 0.0013

ASN 1241 THR 1242 0.0013

THR 1242 ALA 1243 0.0014

ALA 1243 MET 1244 0.0001

MET 1244 ILE 1245 0.1749

ILE 1245 PRO 1246 0.0006

PRO 1246 ARG 1247 0.0002

ARG 1247 SER 1248 0.0004

SER 1248 ILE 1249 0.0004

ILE 1249 GLN 1250 0.0005

GLN 1250 GLU 1251 0.0002

GLU 1251 LEU 1252 0.0001

LEU 1252 TYR 1253 0.0003

TYR 1253 LEU 1254 0.0000

LEU 1254 SER 1255 0.0003

SER 1255 SER 1256 0.0003

SER 1256 ALA 1257 0.0002

ALA 1257 LEU 1258 0.0005

LEU 1258 THR 1259 0.0003

THR 1259 SER 1260 0.0007

SER 1260 ASP 1261 0.0247

ASP 1261 VAL 1262 -0.0000

VAL 1262 GLY 1263 0.0005

GLY 1263 GLN 1264 0.0000

GLN 1264 CYS 1265 0.0005

CYS 1265 LEU 1266 0.0003

LEU 1266 VAL 1267 0.0006

VAL 1267 SER 1268 0.0006

SER 1268 ASP 1269 0.0004

ASP 1269 THR 1270 0.0006

THR 1270 SER 1271 0.0006

SER 1271 LEU 1272 0.0005

LEU 1272 ILE 1273 0.0001

ILE 1273 ARG 1274 0.0006

ARG 1274 TYR 1275 -0.0001

TYR 1275 ASP 1276 0.0006

ASP 1276 GLY 1277 0.0128

GLY 1277 GLN 1278 0.0007

GLN 1278 SER 1279 0.0008

SER 1279 PHE 1280 0.0007

PHE 1280 THR 1281 0.0010

THR 1281 VAL 1282 0.0006

VAL 1282 ASN 1283 0.0007

ASN 1283 VAL 1284 0.0001

VAL 1284 ASP 1285 0.0010

ASP 1285 VAL 1286 -0.0000

VAL 1286 SER 1287 0.0006

SER 1287 SER 1288 0.0001

SER 1288 LYS 1289 0.0007

LYS 1289 ALA 1290 0.0007

ALA 1290 ASP 1291 0.0003

ASP 1291 SER 1292 0.0007

SER 1292 GLU 1293 0.0432

GLU 1293 HIS 1294 0.0010

HIS 1294 THR 1295 0.0010

THR 1295 PRO 1296 0.0009

PRO 1296 VAL 1297 0.0010

VAL 1297 LEU 1298 0.0007

LEU 1298 GLU 1299 0.0001

GLU 1299 ILE 1300 0.0006

ILE 1300 LYS 1301 0.0000

LYS 1301 GLY 1302 0.0008

GLY 1302 LEU 1303 0.0007

LEU 1303 ARG 1304 0.0009

ARG 1304 ASN 1305 0.0011

ASN 1305 GLN 1306 0.0009

GLN 1306 SER 1307 0.0011

SER 1307 VAL 1308 0.0013

VAL 1308 GLY 1309 0.2334

GLY 1309 GLN 1310 0.0061

GLN 1310 MET 1311 0.0126

MET 1311 ALA 1312 0.0026

ALA 1312 PRO 1313 0.0108

PRO 1313 GLN 1314 0.0125

GLN 1314 PRO 1315 0.0034

PRO 1315 GLY 1316 0.0119

GLY 1316 ASP 1317 0.0103

ASP 1317 SER 1318 0.0059

SER 1318 SER 1319 0.0129

SER 1319 ASN 1320 0.0047

ASN 1320 ASN 1321 0.0078

ASN 1321 ASP 1322 0.0065

ASP 1322 LEU 1323 0.0120

LEU 1323 CYS 1324 0.0011

CYS 1324 PHE 1325 0.3462

PHE 1325 LYS 1326 0.0348

LYS 1326 LEU 1327 0.0270

LEU 1327 ASP 1328 0.0254

ASP 1328 TRP 1329 0.0309

TRP 1329 ALA 1330 0.0259

ALA 1330 PRO 1331 0.0357

PRO 1331 ASP 1332 0.0347

ASP 1332 ILE 1333 0.0154

ILE 1333 SER 1334 0.0234

SER 1334 SER 1335 0.0270

SER 1335 VAL 1336 0.0186

VAL 1336 LYS 1337 0.0369

LYS 1337 GLN 1338 0.0072

GLN 1338 GLU 1339 0.0367

GLU 1339 ARG 1340 0.0367

ARG 1340 LEU 1341 -0.4295

LEU 1341 LYS 1342 0.0470

LYS 1342 GLU 1343 0.1351

GLU 1343 LYS 1344 0.1362

LYS 1344 PHE 1345 0.0873

PHE 1345 GLY 1346 0.0554

GLY 1346 PHE 1347 0.0910

PHE 1347 PRO 1348 0.1223

PRO 1348 LEU 1349 0.0037

LEU 1349 ASP 1350 0.1511

ASP 1350 PRO 1351 0.0602

PRO 1351 THR 1352 0.1464

THR 1352 GLU 1353 0.1607

GLU 1353 ALA 1354 0.1283

ALA 1354 ASP 1355 0.0768

ASP 1355 ILE 1356 0.1611

ILE 1356 ILE 1357 0.2099

ILE 1357 MET 1358 0.0958

MET 1358 GLY 1359 0.1889

GLY 1359 LEU 1360 0.2199

LEU 1360 ARG 1361 0.2163

ARG 1361 GLN 1362 0.0647

GLN 1362 ALA 1363 0.2358

ALA 1363 CYS 1364 0.2289

CYS 1364 ILE 1365 0.1289

ILE 1365 HIS 1366 0.1516

HIS 1366 PHE 1367 0.2259

PHE 1367 ILE 1368 0.2363

ILE 1368 HIS 1369 0.0686

HIS 1369 ARG 1370 0.2039

ARG 1370 SER 1371 0.2148

SER 1371 LEU 1372 0.2194

LEU 1372 GLN 1373 0.0609

GLN 1373 SER 1374 0.2506

SER 1374 LEU 1375 0.2208

LEU 1375 THR 1376 0.1303

THR 1376 ALA 1377 0.2504

ALA 1377 PRO 1378 0.2426

PRO 1378 ASP 1379 0.1359

ASP 1379 ARG 1380 0.2168

ARG 1380 ASP 1381 0.2507

ASP 1381 GLN 1382 0.2024

GLN 1382 LEU 1383 0.1271

LEU 1383 ASP 1384 0.0573

ASP 1384 TRP 1385 0.1986

TRP 1385 HIS 1386 0.1968

HIS 1386 GLN 1387 0.0950

GLN 1387 LYS 1388 0.2195

LYS 1388 ARG 1389 0.1253

ARG 1389 PHE 1390 0.2394

PHE 1390 TYR 1391 0.0174

TYR 1391 ASP 1392 0.2336

ASP 1392 TRP 1393 0.1535

TRP 1393 MET 1394 0.1424

MET 1394 VAL 1395 0.1545

VAL 1395 LEU 1396 0.1402

LEU 1396 GLN 1397 0.2351

GLN 1397 ILE 1398 0.0186

ILE 1398 GLN 1399 0.2414

GLN 1399 LEU 1400 0.0942

LEU 1400 ALA 1401 0.2048

ALA 1401 GLU 1402 0.0932

GLU 1402 GLU 1403 0.1760

GLU 1403 ASP 1404 0.2011

ASP 1404 ARG 1405 0.1311

ARG 1405 LEU 1406 0.2271

LEU 1406 ALA 1407 0.2481

ALA 1407 PRO 1408 0.1989

PRO 1408 ASN 1409 0.0359

ASN 1409 SER 1410 0.2444

SER 1410 SER 1411 0.0385

SER 1411 ALA 1412 0.2311

ALA 1412 TRP 1413 0.2038

TRP 1413 LEU 1414 0.1348

LEU 1414 GLN 1415 0.1449

GLN 1415 CYS 1416 0.2185

CYS 1416 SER 1417 0.1776

SER 1417 SER 1418 0.2436

SER 1418 SER 1419 0.2316

SER 1419 ASP 1420 0.1519

ASP 1420 GLU 1421 0.2499

GLU 1421 GLN 1422 0.2332

GLN 1422 LYS 1423 0.1811

LYS 1423 LEU 1424 0.1837

LEU 1424 LEU 1425 0.2309

LEU 1425 GLU 1426 0.2241

GLU 1426 ASN 1427 0.1649

ASN 1427 VAL 1428 0.2093

VAL 1428 ARG 1429 0.2339

ARG 1429 ALA 1430 0.1959

ALA 1430 SER 1431 0.1796

SER 1431 SER 1432 0.1784

SER 1432 VAL 1433 0.2311

VAL 1433 ASN 1434 0.2098

ASN 1434 GLY 1435 0.0766

GLY 1435 GLN 1436 0.2378

GLN 1436 MET 1437 0.2180

MET 1437 VAL 1438 0.1428

VAL 1438 VAL 1439 0.1413

VAL 1439 HIS 1440 0.2290

HIS 1440 VAL 1441 0.2381

VAL 1441 GLY 1442 0.1301

GLY 1442 LYS 1443 0.1526

LYS 1443 SER 1444 0.2355

SER 1444 MET 1445 0.2382

MET 1445 LEU 1446 0.0494

LEU 1446 ALA 1447 0.2299

ALA 1447 ILE 1448 0.0774

ILE 1448 LEU 1449 0.1925

LEU 1449 ARG 1450 0.1568

ARG 1450 HIS 1451 0.1110

HIS 1451 GLU 1452 0.2266

GLU 1452 ILE 1453 0.0098

ILE 1453 ALA 1454 0.0466

ALA 1454 PRO 1455 0.1947

PRO 1455 LEU 1456 0.0164

LEU 1456 GLU 1457 0.2067

GLU 1457 LEU 1458 0.1535

LEU 1458 MET 1459 0.1042

MET 1459 LEU 1460 0.1327

LEU 1460 GLN 1461 0.1544

GLN 1461 ASP 1462 0.1795

ASP 1462 LYS 1463 0.0950

LYS 1463 LEU 1464 0.1608

LEU 1464 LEU 1465 0.1793

LEU 1465 TYR 1466 0.0454

TYR 1466 ARG 1467 0.1987

ARG 1467 TYR 1468 0.1866

TYR 1468 TYR 1469 0.0641

TYR 1469 THR 1470 0.1364

THR 1470 ASP 1471 0.1234

ASP 1471 ALA 1472 0.1120

ALA 1472 ILE 1473 0.1774

ILE 1473 LYS 1474 0.1055

LYS 1474 TRP 1475 0.1287

TRP 1475 ASP 1476 0.1021

ASP 1476 ARG 1477 0.1707

ARG 1477 SER 1478 0.1741

SER 1478 TYR 1479 0.1281

TYR 1479 GLN 1480 0.1324

GLN 1480 GLN 1481 0.1746

GLN 1481 ILE 1482 0.1652

ILE 1482 ASP 1483 0.1211

ASP 1483 GLN 1484 0.1434

GLN 1484 LEU 1485 0.1516

LEU 1485 VAL 1486 0.1052

VAL 1486 LYS 1487 0.0847

LYS 1487 LEU 1488 0.1062

LEU 1488 HIS 1489 0.1196

HIS 1489 ALA 1490 0.1013

ALA 1490 HIS 1491 0.0783

HIS 1491 LYS 1492 0.1132

LYS 1492 CYS 1493 0.1210

CYS 1493 PRO 1494 0.1199

PRO 1494 THR 1495 0.1171

THR 1495 ALA 1496 0.0378

ALA 1496 LYS 1497 0.1017

LYS 1497 ILE 1498 0.0087

ILE 1498 ILE 1499 0.0432

ILE 1499 GLU 1500 0.0176

GLU 1500 ILE 1501 0.0555

ILE 1501 GLY 1502 0.0619

GLY 1502 ALA 1503 0.1309

ALA 1503 GLY 1504 0.0659

GLY 1504 THR 1505 0.1535

THR 1505 GLY 1506 0.0465

GLY 1506 GLY 1507 0.1343

GLY 1507 CYS 1508 0.1015

CYS 1508 THR 1509 0.0777

THR 1509 ARG 1510 0.1518

ARG 1510 ALA 1511 0.1511

ALA 1511 VAL 1512 0.1035

VAL 1512 LEU 1513 0.1136

LEU 1513 ASP 1514 0.1534

ASP 1514 ALA 1515 0.1394

ALA 1515 LEU 1516 0.0957

LEU 1516 SER 1517 0.0830

SER 1517 ASN 1518 0.0825

ASN 1518 GLN 1519 0.1136

GLN 1519 GLY 1520 0.1138

GLY 1520 ILE 1521 0.0707

ILE 1521 ALA 1522 0.0986

ALA 1522 ARG 1523 0.1070

ARG 1523 CYS 1524 0.1120

CYS 1524 ALA 1525 0.0853

ALA 1525 GLN 1526 0.0429

GLN 1526 TYR 1527 0.0024

TYR 1527 ASP 1528 0.0810

ASP 1528 PHE 1529 0.0263

PHE 1529 THR 1530 0.0736

THR 1530 ASP 1531 0.0112

ASP 1531 VAL 1532 0.0833

VAL 1532 SER 1533 0.2553

SER 1533 SER 1534 0.0950

SER 1534 GLY 1535 0.0831

GLY 1535 PHE 1536 0.1270

PHE 1536 PHE 1537 0.0140

PHE 1537 GLU 1538 0.1522

GLU 1538 ALA 1539 0.1322

ALA 1539 ALA 1540 0.0996

ALA 1540 GLN 1541 0.0590

GLN 1541 GLN 1542 0.1452

GLN 1542 LYS 1543 0.1481

LYS 1543 PHE 1544 0.0463

PHE 1544 ALA 1545 0.0989

ALA 1545 ALA 1546 0.0985

ALA 1546 PHE 1547 0.1486

PHE 1547 ASP 1548 0.1521

ASP 1548 ASP 1549 0.0735

ASP 1549 VAL 1550 0.1357

VAL 1550 ILE 1551 0.0146

ILE 1551 ARG 1552 0.1396

ARG 1552 PHE 1553 0.0153

PHE 1553 GLN 1554 0.1336

GLN 1554 LYS 1555 0.0409

LYS 1555 LEU 1556 0.1466

LEU 1556 ASP 1557 0.0644

ASP 1557 ILE 1558 0.1413

ILE 1558 GLU 1559 0.0932

GLU 1559 LYS 1560 0.1116

LYS 1560 ASP 1561 0.0301

ASP 1561 ILE 1562 0.0788

ILE 1562 GLU 1563 0.0745

GLU 1563 MET 1564 0.0916

MET 1564 GLN 1565 0.1920

GLN 1565 GLY 1566 0.0127

GLY 1566 PHE 1567 0.1417

PHE 1567 GLU 1568 0.0573

GLU 1568 CYS 1569 0.1408

CYS 1569 GLY 1570 0.1168

GLY 1570 SER 1571 0.1311

SER 1571 TYR 1572 0.1106

TYR 1572 ASP 1573 0.1384

ASP 1573 LEU 1574 0.0321

LEU 1574 VAL 1575 0.0306

VAL 1575 ILE 1576 0.0741

ILE 1576 ALA 1577 0.0110

ALA 1577 SER 1578 0.0787

SER 1578 GLN 1579 0.0119

GLN 1579 VAL 1580 0.1425

VAL 1580 LEU 1581 0.1589

LEU 1581 HIS 1582 0.0237

HIS 1582 ALA 1583 0.1420

ALA 1583 THR 1584 0.1279

THR 1584 GLY 1585 0.1359

GLY 1585 LYS 1586 0.1007

LYS 1586 MET 1587 0.1162

MET 1587 GLU 1588 0.0823

GLU 1588 HIS 1589 0.1471

HIS 1589 THR 1590 0.1533

THR 1590 MET 1591 0.1036

MET 1591 ALA 1592 0.1003

ALA 1592 ASN 1593 0.1516

ASN 1593 VAL 1594 0.1515

VAL 1594 ARG 1595 0.0806

ARG 1595 LYS 1596 0.1216

LYS 1596 LEU 1597 0.0891

LEU 1597 LEU 1598 0.1084

LEU 1598 LYS 1599 0.0127

LYS 1599 PRO 1600 0.1381

PRO 1600 GLY 1601 0.1397

GLY 1601 GLY 1602 0.1095

GLY 1602 LYS 1603 0.0633

LYS 1603 LEU 1604 0.0080

LEU 1604 LEU 1605 0.1058

LEU 1605 LEU 1606 0.0039

LEU 1606 VAL 1607 0.0645

VAL 1607 GLU 1608 0.0468

GLU 1608 THR 1609 0.0201

THR 1609 THR 1610 0.1409

THR 1610 ARG 1611 0.0297

ARG 1611 ASP 1612 0.0692

ASP 1612 GLU 1613 0.1281

GLU 1613 MET 1614 0.0321

MET 1614 ASP 1615 0.2130

ASP 1615 LEU 1616 0.1037

LEU 1616 GLN 1617 0.1675

GLN 1617 LEU 1618 0.0857

LEU 1618 VAL 1619 0.1684

VAL 1619 PHE 1620 0.1537

PHE 1620 GLY 1621 0.1469

GLY 1621 LEU 1622 0.1730

LEU 1622 LEU 1623 0.0834

LEU 1623 PRO 1624 0.2123

PRO 1624 GLY 1625 0.0221

GLY 1625 TRP 1626 0.2033

TRP 1626 TRP 1627 0.1903

TRP 1627 LEU 1628 0.1222

LEU 1628 SER 1629 0.3139

SER 1629 SER 1630 0.1836

SER 1630 GLU 1631 0.1745

GLU 1631 GLU 1632 0.0914

GLU 1632 GLU 1633 0.1750

GLU 1633 ARG 1634 0.1858

ARG 1634 GLN 1635 0.0548

GLN 1635 MET 1636 0.1476

MET 1636 SER 1637 0.0866

SER 1637 PRO 1638 0.0662

PRO 1638 SER 1639 0.1468

SER 1639 LEU 1640 0.1326

LEU 1640 SER 1641 0.1848

SER 1641 THR 1642 0.0362

THR 1642 ASN 1643 0.1857

ASN 1643 SER 1644 0.1806

SER 1644 TRP 1645 0.1792

TRP 1645 GLU 1646 0.0883

GLU 1646 LYS 1647 0.1473

LYS 1647 VAL 1648 0.1514

VAL 1648 LEU 1649 0.0471

LEU 1649 LYS 1650 0.1253

LYS 1650 LYS 1651 0.1393

LYS 1651 THR 1652 0.1388

THR 1652 GLY 1653 0.0166

GLY 1653 PHE 1654 0.1507

PHE 1654 ASP 1655 0.1426

ASP 1655 GLY 1656 0.0293

GLY 1656 LEU 1657 0.1375

LEU 1657 ASP 1658 0.0731

ASP 1658 ILE 1659 0.0990

ILE 1659 GLU 1660 0.0039

GLU 1660 LEU 1661 0.1448

LEU 1661 ARG 1662 0.0138

ARG 1662 ASP 1663 0.1396

ASP 1663 CYS 1664 0.1504

CYS 1664 ASP 1665 0.1593

ASP 1665 SER 1666 0.0147

SER 1666 ASP 1667 0.1436

ASP 1667 GLU 1668 0.0400

GLU 1668 PHE 1669 0.1524

PHE 1669 TYR 1670 0.0573

TYR 1670 SER 1671 0.1591

SER 1671 PHE 1672 0.0390

PHE 1672 SER 1673 0.0509

SER 1673 VAL 1674 0.0375

VAL 1674 MET 1675 0.1352

MET 1675 MET 1676 0.0214

MET 1676 ALA 1677 0.2586

ALA 1677 THR 1678 0.0221

THR 1678 ALA 1679 0.0686

ALA 1679 SER 1680 0.0178

SER 1680 SER 1681 0.0309

SER 1681 THR 1682 0.0088

THR 1682 ILE 1683 0.0542

ILE 1683 ALA 1684 0.0261

ALA 1684 SER 1685 0.0337

SER 1685 SER 1686 0.0612

SER 1686 SER 1687 0.0051

SER 1687 MET 1688 0.0773

MET 1688 ALA 1689 0.0529

ALA 1689 PHE 1690 0.0630

PHE 1690 ALA 1691 0.0740

ALA 1691 ILE 1692 0.0639

ILE 1692 VAL 1693 0.1975

VAL 1693 TYR 1694 0.0615

TYR 1694 GLY 1695 0.0623

GLY 1695 GLU 1696 0.0470

GLU 1696 VAL 1697 0.0535

VAL 1697 PRO 1698 0.0589

PRO 1698 LEU 1699 0.0280

LEU 1699 PRO 1700 0.0623

PRO 1700 ASP 1701 0.0435

ASP 1701 GLN 1702 0.0268

GLN 1702 PHE 1703 0.0417

PHE 1703 LEU 1704 0.0296

LEU 1704 ASP 1705 0.0609

ASP 1705 ASP 1706 0.0025

ASP 1706 MET 1707 0.0624

MET 1707 LYS 1708 0.0259

LYS 1708 THR 1709 0.0942

THR 1709 ALA 1710 0.0204

ALA 1710 ILE 1711 0.0565

ILE 1711 SER 1712 0.0494

SER 1712 SER 1713 0.0230

SER 1713 SER 1714 0.0605

SER 1714 ALA 1715 0.0224

ALA 1715 VAL 1716 0.0303

VAL 1716 SER 1717 0.0370

SER 1717 ASP 1718 0.0673

ASP 1718 PRO 1719 0.0697

PRO 1719 VAL 1720 0.0273

VAL 1720 VAL 1721 0.0689

VAL 1721 GLY 1722 0.0558

GLY 1722 HIS 1723 0.0704

HIS 1723 LEU 1724 0.0651

LEU 1724 ASP 1725 0.0736

ASP 1725 SER 1726 0.0357

SER 1726 ILE 1727 0.0437

ILE 1727 ASP 1728 0.0520

ASP 1728 ALA 1729 0.0122

ALA 1729 THR 1730 0.0459

THR 1730 GLY 1731 0.0456

GLY 1731 LYS 1732 0.0421

LYS 1732 PHE 1733 0.0015

PHE 1733 CYS 1734 0.0551

CYS 1734 ILE 1735 0.0324

ILE 1735 PHE 1736 0.0557

PHE 1736 ILE 1737 0.0464

ILE 1737 GLU 1738 0.0550

GLU 1738 ASP 1739 0.0550

ASP 1739 PRO 1740 0.0068

PRO 1740 GLU 1741 0.0075

GLU 1741 THR 1742 0.0445

THR 1742 ASP 1743 0.0411

ASP 1743 ILE 1744 0.0233

ILE 1744 LEU 1745 0.0390

LEU 1745 SER 1746 0.0427

SER 1746 SER 1747 0.0203

SER 1747 PRO 1748 0.0223

PRO 1748 ASP 1749 0.0085

ASP 1749 GLU 1750 0.0370

GLU 1750 LYS 1751 0.0423

LYS 1751 SER 1752 0.0234

SER 1752 TYR 1753 0.0438

TYR 1753 ALA 1754 0.0217

ALA 1754 SER 1755 0.0557

SER 1755 ILE 1756 0.0048

ILE 1756 GLN 1757 0.0691

GLN 1757 LYS 1758 0.0243

LYS 1758 LEU 1759 0.0360

LEU 1759 VAL 1760 0.0265

VAL 1760 THR 1761 0.0307

THR 1761 ARG 1762 0.0354

ARG 1762 CYS 1763 0.0337

CYS 1763 LYS 1764 0.0479

LYS 1764 GLY 1765 0.0120

GLY 1765 LEU 1766 0.0472

LEU 1766 ILE 1767 0.0272

ILE 1767 TRP 1768 0.0527

TRP 1768 VAL 1769 0.0434

VAL 1769 SER 1770 0.0364

SER 1770 ARG 1771 0.0269

ARG 1771 GLY 1772 0.0130

GLY 1772 GLY 1773 0.1387

GLY 1773 ALA 1774 0.0238

ALA 1774 MET 1775 0.0116

MET 1775 HIS 1776 0.0325

HIS 1776 GLY 1777 0.0247

GLY 1777 THR 1778 0.0325

THR 1778 ARG 1779 0.0142

ARG 1779 PRO 1780 0.0322

PRO 1780 ASN 1781 0.0054

ASN 1781 SER 1782 0.0324

SER 1782 SER 1783 0.0217

SER 1783 LEU 1784 0.0261

LEU 1784 LYS 1785 0.0219

LYS 1785 THR 1786 0.0149

THR 1786 GLY 1787 0.0316

GLY 1787 LEU 1788 0.0043

LEU 1788 LEU 1789 0.0718

LEU 1789 ARG 1790 0.0175

ARG 1790 THR 1791 0.0329

THR 1791 LEU 1792 0.0149

LEU 1792 ARG 1793 0.0356

ARG 1793 LEU 1794 0.0454

LEU 1794 GLU 1795 0.0058

GLU 1795 TYR 1796 0.0381

TYR 1796 THR 1797 0.0294

THR 1797 GLU 1798 0.0240

GLU 1798 LYS 1799 0.0463

LYS 1799 ARG 1800 0.0285

ARG 1800 PHE 1801 0.0431

PHE 1801 ILE 1802 0.0314

ILE 1802 SER 1803 0.0386

SER 1803 LEU 1804 0.0446

LEU 1804 ASP 1805 0.0725

ASP 1805 LEU 1806 0.0568

LEU 1806 ASP 1807 0.0264

ASP 1807 SER 1808 0.0560

SER 1808 ALA 1809 0.0359

ALA 1809 ARG 1810 0.0405

ARG 1810 PRO 1811 0.0157

PRO 1811 GLN 1812 0.0203

GLN 1812 TRP 1813 0.0417

TRP 1813 ASN 1814 0.0370

ASN 1814 HIS 1815 0.0572

HIS 1815 ASP 1816 0.0208

ASP 1816 SER 1817 0.0422

SER 1817 ILE 1818 0.0305

ILE 1818 THR 1819 0.0277

THR 1819 THR 1820 0.0492

THR 1820 ILE 1821 0.0338

ILE 1821 ASN 1822 0.0487

ASN 1822 GLU 1823 0.0076

GLU 1823 VAL 1824 0.0451

VAL 1824 LEU 1825 0.0164

LEU 1825 CYS 1826 0.0352

CYS 1826 GLY 1827 0.0313

GLY 1827 ALA 1828 0.0182

ALA 1828 LEU 1829 0.0432

LEU 1829 ALA 1830 0.0150

ALA 1830 GLN 1831 0.0457

GLN 1831 ASN 1832 0.0473

ASN 1832 ALA 1833 0.0486

ALA 1833 ASP 1834 0.0051

ASP 1834 SER 1835 0.0420

SER 1835 SER 1836 0.0485

SER 1836 ILE 1837 -0.0363

ILE 1837 LYS 1838 0.0230

LYS 1838 ASP 1839 0.0376

ASP 1839 SER 1840 0.0164

SER 1840 GLU 1841 0.0314

GLU 1841 PHE 1842 0.0342

PHE 1842 ALA 1843 0.0341

ALA 1843 GLU 1844 0.0372

GLU 1844 GLN 1845 0.0144

GLN 1845 ASP 1846 0.0344

ASP 1846 GLY 1847 0.0270

GLY 1847 GLN 1848 0.0327

GLN 1848 LEU 1849 0.0295

LEU 1849 PHE 1850 0.0326

PHE 1850 VAL 1851 0.0373

VAL 1851 PRO 1852 0.0374

PRO 1852 ARG 1853 0.0485

ARG 1853 ILE 1854 0.0011

ILE 1854 SER 1855 0.0039

SER 1855 CYS 1856 0.0002

CYS 1856 ASP 1857 0.0063

ASP 1857 ILE 1858 0.0048

ILE 1858 ALA 1859 0.0067

ALA 1859 ARG 1860 0.0072

ARG 1860 ASN 1861 0.0069

ASN 1861 GLU 1862 0.0052

GLU 1862 ASP 1863 0.0071

ASP 1863 LEU 1864 0.0074

LEU 1864 SER 1865 0.0063

SER 1865 SER 1866 0.0057

SER 1866 ASP 1867 0.0025

ASP 1867 SER 1868 0.0075

SER 1868 ASN 1869 0.1016

ASN 1869 SER 1870 0.0369

SER 1870 PRO 1871 0.0383

PRO 1871 ALA 1872 0.0294

ALA 1872 GLN 1873 0.0268

GLN 1873 MET 1874 0.0399

MET 1874 GLU 1875 0.0373

GLU 1875 PRO 1876 0.0331

PRO 1876 PHE 1877 0.0005

PHE 1877 HIS 1878 0.0408

HIS 1878 GLN 1879 0.0360

GLN 1879 PRO 1880 0.0390

PRO 1880 GLY 1881 0.0342

GLY 1881 LYS 1882 0.0410

LYS 1882 LEU 1883 0.0163

LEU 1883 LEU 1884 0.0399

LEU 1884 GLN 1885 0.0483

GLN 1885 MET 1886 0.0186

MET 1886 GLY 1887 0.0182

GLY 1887 ILE 1888 0.0178

ILE 1888 LYS 1889 0.0096

LYS 1889 THR 1890 0.0154

THR 1890 PRO 1891 0.0015

PRO 1891 GLY 1892 0.0184

GLY 1892 LEU 1893 0.0045

LEU 1893 ILE 1894 0.0181

ILE 1894 ASP 1895 0.0005

ASP 1895 THR 1896 0.0184

THR 1896 LEU 1897 0.0145

LEU 1897 GLN 1898 0.0133

GLN 1898 PHE 1899 0.0184

PHE 1899 SER 1900 0.0182

SER 1900 LYS 1901 0.0903

LYS 1901 THR 1902 0.0077

THR 1902 ASP 1903 0.0241

ASP 1903 ALA 1904 0.0215

ALA 1904 THR 1905 0.0116

THR 1905 ASP 1906 0.0247

ASP 1906 ASN 1907 0.0005

ASN 1907 LEU 1908 0.0183

LEU 1908 PRO 1909 0.0023

PRO 1909 ASN 1910 0.0139

ASN 1910 ASP 1911 0.0202

ASP 1911 TYR 1912 0.0067

TYR 1912 ILE 1913 0.0156

ILE 1913 GLU 1914 0.0011

GLU 1914 ILE 1915 0.0219

ILE 1915 GLU 1916 0.0030

GLU 1916 PRO 1917 0.0356

PRO 1917 LYS 1918 0.0167

LYS 1918 ALA 1919 0.0137

ALA 1919 PHE 1920 0.0137

PHE 1920 GLY 1921 0.0088

GLY 1921 LEU 1922 0.0180

LEU 1922 ASN 1923 0.0066

ASN 1923 PHE 1924 0.0171

PHE 1924 ARG 1925 0.0183

ARG 1925 ASP 1926 0.0011

ASP 1926 VAL 1927 0.0174

VAL 1927 MET 1928 0.0107

MET 1928 VAL 1929 0.0150

VAL 1929 ALA 1930 0.0032

ALA 1930 MET 1931 0.0165

MET 1931 GLY 1932 0.0158

GLY 1932 GLN 1933 0.0484

GLN 1933 LEU 1934 0.0151

LEU 1934 GLU 1935 0.0178

GLU 1935 GLU 1936 0.0165

GLU 1936 SER 1937 0.0009

SER 1937 ILE 1938 0.0177

ILE 1938 MET 1939 0.0162

MET 1939 GLY 1940 0.0179

GLY 1940 PHE 1941 0.0035

PHE 1941 GLU 1942 0.0177

GLU 1942 CYS 1943 0.0103

CYS 1943 ALA 1944 0.0176

ALA 1944 GLY 1945 0.0102

GLY 1945 VAL 1946 0.0171

VAL 1946 VAL 1947 0.0162

VAL 1947 ARG 1948 0.0064

ARG 1948 ARG 1949 0.0055

ARG 1949 VAL 1950 0.0016

VAL 1950 GLY 1951 0.0167

GLY 1951 PRO 1952 0.0168

PRO 1952 SER 1953 0.0034

SER 1953 SER 1954 0.0199

SER 1954 ALA 1955 0.0196

ALA 1955 GLY 1956 0.0016

GLY 1956 HIS 1957 0.0207

HIS 1957 ASN 1958 0.0158

ASN 1958 ILE 1959 0.0072

ILE 1959 LYS 1960 0.0053

LYS 1960 VAL 1961 0.0015

VAL 1961 GLY 1962 0.0180

GLY 1962 ASP 1963 0.0059

ASP 1963 ARG 1964 0.0212

ARG 1964 VAL 1965 0.0448

VAL 1965 CYS 1966 0.0190

CYS 1966 ALA 1967 0.0186

ALA 1967 LEU 1968 0.0174

LEU 1968 LEU 1969 0.0124

LEU 1969 GLY 1970 0.0196

GLY 1970 GLY 1971 0.0105

GLY 1971 GLN 1972 0.0020

GLN 1972 TRP 1973 0.0100

TRP 1973 THR 1974 0.0154

THR 1974 ASN 1975 0.0142

ASN 1975 THR 1976 0.0124

THR 1976 VAL 1977 0.0014

VAL 1977 ARG 1978 0.0117

ARG 1978 VAL 1979 0.0008

VAL 1979 HIS 1980 0.0044

HIS 1980 TRP 1981 -0.0104

TRP 1981 HIS 1982 0.0045

HIS 1982 SER 1983 0.0122

SER 1983 VAL 1984 0.0141

VAL 1984 ALA 1985 0.0154

ALA 1985 PRO 1986 0.0138

PRO 1986 ILE 1987 0.0158

ILE 1987 PRO 1988 0.0168

PRO 1988 GLN 1989 0.0050

GLN 1989 ALA 1990 0.0170

ALA 1990 MET 1991 0.0171

MET 1991 ASP 1992 0.0050

ASP 1992 TRP 1993 0.0160

TRP 1993 GLU 1994 0.0168

GLU 1994 THR 1995 0.0019

THR 1995 ALA 1996 0.0166

ALA 1996 ALA 1997 0.0343

ALA 1997 SER 1998 0.0067

SER 1998 ILE 1999 0.0047

ILE 1999 PRO 2000 0.0108

PRO 2000 ILE 2001 0.0111

ILE 2001 VAL 2002 0.0071

VAL 2002 PHE 2003 0.0054

PHE 2003 VAL 2004 0.0111

VAL 2004 THR 2005 0.0112

THR 2005 ALA 2006 0.0042

ALA 2006 TYR 2007 0.0091

TYR 2007 ILE 2008 0.0108

ILE 2008 SER 2009 0.0102

SER 2009 LEU 2010 0.0043

LEU 2010 VAL 2011 0.0101

VAL 2011 LYS 2012 0.0106

LYS 2012 ILE 2013 0.0801

ILE 2013 ALA 2014 0.0016

ALA 2014 ARG 2015 0.0040

ARG 2015 MET 2016 0.0036

MET 2016 GLN 2017 0.0014

GLN 2017 ALA 2018 0.0031

ALA 2018 GLY 2019 0.0032

GLY 2019 GLU 2020 0.0030

GLU 2020 THR 2021 0.0046

THR 2021 VAL 2022 0.0002

VAL 2022 LEU 2023 0.0038

LEU 2023 ILE 2024 0.0010

ILE 2024 HIS 2025 0.0027

HIS 2025 ALA 2026 0.0030

ALA 2026 ALA 2027 0.0033

ALA 2027 SER 2028 0.0039

SER 2028 GLY 2029 0.0034

GLY 2029 GLY 2030 0.0087

GLY 2030 VAL 2031 0.0066

VAL 2031 GLY 2032 0.0042

GLY 2032 GLN 2033 0.0090

GLN 2033 ALA 2034 0.0089

ALA 2034 ALA 2035 0.0042

ALA 2035 ILE 2036 0.0064

ILE 2036 ILE 2037 0.0088

ILE 2037 LEU 2038 0.0082

LEU 2038 ALA 2039 0.0038

ALA 2039 LYS 2040 0.0079

LYS 2040 HIS 2041 0.0087

HIS 2041 VAL 2042 0.0061

VAL 2042 GLY 2043 0.0050

GLY 2043 ALA 2044 0.0089

ALA 2044 GLU 2045 -0.0408

GLU 2045 ILE 2046 0.0036

ILE 2046 PHE 2047 0.0084

PHE 2047 ALA 2048 0.0022

ALA 2048 THR 2049 0.0061

THR 2049 VAL 2050 0.0048

VAL 2050 GLY 2051 0.0060

GLY 2051 THR 2052 0.0084

THR 2052 ASP 2053 0.0051

ASP 2053 GLU 2054 0.0052

GLU 2054 LYS 2055 0.0085

LYS 2055 ARG 2056 0.0000

ARG 2056 ASP 2057 0.0085

ASP 2057 LEU 2058 0.0058

LEU 2058 LEU 2059 0.0052

LEU 2059 ILE 2060 0.0032

ILE 2060 LYS 2061 0.0201

LYS 2061 GLU 2062 0.0053

GLU 2062 TYR 2063 0.0065

TYR 2063 LYS 2064 0.0007

LYS 2064 ILE 2065 0.0078

ILE 2065 PRO 2066 0.0030

PRO 2066 ASP 2067 0.0070

ASP 2067 ASP 2068 0.0054

ASP 2068 HIS 2069 0.0051

HIS 2069 ILE 2070 0.0022

ILE 2070 PHE 2071 0.0069

PHE 2071 SER 2072 0.0030

SER 2072 SER 2073 0.0035

SER 2073 ARG 2074 0.0070

ARG 2074 ASN 2075 0.0032

ASN 2075 ALA 2076 0.0053

ALA 2076 LEU 2077 0.0465

LEU 2077 PHE 2078 0.0046

PHE 2078 ALA 2079 0.0043

ALA 2079 LYS 2080 0.0018

LYS 2080 SER 2081 0.0042

SER 2081 ILE 2082 0.0048

ILE 2082 ARG 2083 0.0035

ARG 2083 GLN 2084 0.0024

GLN 2084 ARG 2085 0.0046

ARG 2085 THR 2086 0.0046

THR 2086 ASN 2087 0.0023

ASN 2087 GLY 2088 0.0024

GLY 2088 LYS 2089 0.0043

LYS 2089 GLY 2090 0.0008

GLY 2090 VAL 2091 0.0037

VAL 2091 ASP 2092 0.0046

ASP 2092 VAL 2093 -0.0243

VAL 2093 VAL 2094 0.0004

VAL 2094 LEU 2095 0.0010

LEU 2095 ASN 2096 0.0012

ASN 2096 CYS 2097 0.0001

CYS 2097 LEU 2098 0.0028

LEU 2098 ALA 2099 0.0024

ALA 2099 GLY 2100 0.0029

GLY 2100 GLY 2101 0.0014

GLY 2101 LEU 2102 0.0028

LEU 2102 LEU 2103 0.0027

LEU 2103 GLN 2104 0.0020

GLN 2104 GLU 2105 0.0024

GLU 2105 SER 2106 0.0029

SER 2106 PHE 2107 0.0025

PHE 2107 ASP 2108 0.0020

ASP 2108 CYS 2109 -0.0200

CYS 2109 LEU 2110 0.0023

LEU 2110 ALA 2111 -0.0001

ALA 2111 ASP 2112 0.0019

ASP 2112 PHE 2113 0.0028

PHE 2113 GLY 2114 0.0015

GLY 2114 ARG 2115 0.0011

ARG 2115 PHE 2116 0.0002

PHE 2116 ILE 2117 0.0016

ILE 2117 GLU 2118 0.0002

GLU 2118 ILE 2119 0.0017

ILE 2119 GLY 2120 0.0011

GLY 2120 LYS 2121 0.0015

LYS 2121 ARG 2122 0.0021

ARG 2122 ASP 2123 0.0019

ASP 2123 ILE 2124 0.0027

ILE 2124 GLU 2125 -0.0163

GLU 2125 LEU 2126 -0.0001

LEU 2126 ASN 2127 0.0001

ASN 2127 HIS 2128 0.0001

HIS 2128 CYS 2129 0.0002

CYS 2129 LEU 2130 0.0001

LEU 2130 ASN 2131 -0.0000

ASN 2131 MET 2132 0.0001

MET 2132 GLY 2133 0.0002

GLY 2133 MET 2134 0.0000

MET 2134 PHE 2135 0.0000

PHE 2135 ALA 2136 0.0001

ALA 2136 ARG 2137 0.0001

ARG 2137 SER 2138 0.0000

SER 2138 ALA 2139 0.0001

ALA 2139 THR 2140 0.0002

THR 2140 PHE 2141 0.0366

PHE 2141 THR 2142 0.0033

THR 2142 ALA 2143 -0.0000

ALA 2143 VAL 2144 0.0055

VAL 2144 ASP 2145 0.0003

ASP 2145 LEU 2146 0.0061

LEU 2146 ILE 2147 0.0026

ILE 2147 ALA 2148 0.0051

ALA 2148 ILE 2149 0.0052

ILE 2149 GLY 2150 0.0023

GLY 2150 ARG 2151 0.0065

ARG 2151 ASP 2152 0.0022

ASP 2152 ARG 2153 0.0045

ARG 2153 SER 2154 0.0046

SER 2154 TYR 2155 0.0037

TYR 2155 MET 2156 0.0061

MET 2156 PHE 2157 0.0582

PHE 2157 ALA 2158 0.0122

ALA 2158 GLU 2159 0.0018

GLU 2159 ALA 2160 0.0121

ALA 2160 LEU 2161 0.0028

LEU 2161 PRO 2162 0.0120

PRO 2162 LYS 2163 0.0022

LYS 2163 ILE 2164 0.0103

ILE 2164 MET 2165 0.0072

MET 2165 THR 2166 0.0057

THR 2166 LEU 2167 0.0091

LEU 2167 LEU 2168 0.0039

LEU 2168 GLN 2169 0.0118

GLN 2169 GLU 2170 0.0013

GLU 2170 LYS 2171 0.0118

LYS 2171 ALA 2172 0.0042

ALA 2172 ILE 2173 0.0297

ILE 2173 ARG 2174 0.0044

ARG 2174 PRO 2175 0.0050

PRO 2175 VAL 2176 0.0164

VAL 2176 THR 2177 0.0138

THR 2177 PRO 2178 0.0040

PRO 2178 ILE 2179 0.0101

ILE 2179 SER 2180 0.0054

SER 2180 ILE 2181 0.0066

ILE 2181 TYR 2182 0.0050

TYR 2182 LYS 2183 0.0065

LYS 2183 ILE 2184 0.0165

ILE 2184 GLY 2185 0.0047

GLY 2185 ASP 2186 0.0120

ASP 2186 ILE 2187 0.0105

ILE 2187 GLU 2188 0.0162

GLU 2188 THR 2189 0.0394

THR 2189 ALA 2190 0.0046

ALA 2190 PHE 2191 0.0164

PHE 2191 ARG 2192 0.0161

ARG 2192 LEU 2193 0.0110

LEU 2193 MET 2194 0.0082

MET 2194 GLN 2195 0.0162

GLN 2195 ALA 2196 0.0167

ALA 2196 GLY 2197 0.0036

GLY 2197 LYS 2198 0.0157

LYS 2198 HIS 2199 0.0162

HIS 2199 MET 2200 0.0065

MET 2200 GLY 2201 0.0152

GLY 2201 LYS 2202 0.0103

LYS 2202 ILE 2203 0.0006

ILE 2203 VAL 2204 0.0138

VAL 2204 ILE 2205 0.0779

ILE 2205 THR 2206 0.0332

THR 2206 ALA 2207 0.0253

ALA 2207 PRO 2208 0.0278

PRO 2208 GLU 2209 0.0244

GLU 2209 ASP 2210 0.0155

ASP 2210 ALA 2211 0.0331

ALA 2211 MET 2212 0.0246

MET 2212 VAL 2213 0.0340

VAL 2213 PRO 2214 0.0325

PRO 2214 VAL 2215 0.0392

VAL 2215 ILE 2216 0.0373

ILE 2216 THR 2217 0.0359

THR 2217 ARG 2218 0.0332

ARG 2218 PRO 2219 0.0266

PRO 2219 PRO 2220 0.0316

PRO 2220 LYS 2221 0.2256

LYS 2221 LEU 2222 0.0327

LEU 2222 GLN 2223 0.0171

GLN 2223 LEU 2224 0.0337

LEU 2224 ARG 2225 0.0265

ARG 2225 PRO 2226 0.0123

PRO 2226 ASP 2227 0.0337

ASP 2227 ALA 2228 0.0055

ALA 2228 SER 2229 0.0277

SER 2229 TYR 2230 0.0174

TYR 2230 LEU 2231 0.0192

LEU 2231 ILE 2232 0.0299

ILE 2232 VAL 2233 0.0162

VAL 2233 GLY 2234 0.0340

GLY 2234 GLY 2235 0.0048

GLY 2235 LEU 2236 0.0322

LEU 2236 GLY 2237 -0.0000

GLY 2237 GLY 2238 0.0321

GLY 2238 ILE 2239 0.0226

ILE 2239 GLY 2240 0.0278

GLY 2240 ARG 2241 0.0043

ARG 2241 SER 2242 0.0301

SER 2242 LEU 2243 0.0273

LEU 2243 CYS 2244 0.0098

CYS 2244 LYS 2245 0.0222

LYS 2245 ASN 2246 0.0199

ASN 2246 PHE 2247 0.0325

PHE 2247 VAL 2248 0.0005

VAL 2248 GLU 2249 0.0322

GLU 2249 ASN 2250 0.0168

ASN 2250 GLY 2251 0.0244

GLY 2251 ALA 2252 0.0306

ALA 2252 ARG 2253 -0.0765

ARG 2253 SER 2254 0.0291

SER 2254 LEU 2255 0.0219

LEU 2255 VAL 2256 0.0279

VAL 2256 LEU 2257 0.0359

LEU 2257 LEU 2258 0.0180

LEU 2258 SER 2259 0.0395

SER 2259 ARG 2260 0.0338

ARG 2260 ASN 2261 0.0167

ASN 2261 ALA 2262 0.0149

ALA 2262 ASN 2263 0.0287

ASN 2263 VAL 2264 0.0415

VAL 2264 SER 2265 0.0112

SER 2265 GLN 2266 0.0364

GLN 2266 GLN 2267 0.0272

GLN 2267 SER 2268 0.0413

SER 2268 GLY 2269 -0.0548

GLY 2269 GLU 2270 0.0504

GLU 2270 PHE 2271 0.0196

PHE 2271 LEU 2272 0.0537

LEU 2272 ASP 2273 0.0030

ASP 2273 GLU 2274 0.0509

GLU 2274 LEU 2275 0.0351

LEU 2275 ARG 2276 0.0301

ARG 2276 SER 2277 0.0284

SER 2277 THR 2278 0.0388

THR 2278 GLY 2279 0.0538

GLY 2279 CYS 2280 0.0065

CYS 2280 ILE 2281 0.0529

ILE 2281 VAL 2282 0.0403

VAL 2282 GLY 2283 0.0445

GLY 2283 VAL 2284 0.0478

VAL 2284 VAL 2285 0.2437

VAL 2285 ASP 2286 0.0211

ASP 2286 CYS 2287 0.0068

CYS 2287 ASP 2288 0.0073

ASP 2288 ILE 2289 0.0298

ILE 2289 SER 2290 0.0053

SER 2290 SER 2291 0.0343

SER 2291 LYS 2292 0.0339

LYS 2292 THR 2293 0.0267

THR 2293 GLN 2294 0.0123

GLN 2294 VAL 2295 0.0349

VAL 2295 GLU 2296 0.0347

GLU 2296 ALA 2297 0.0167

ALA 2297 THR 2298 0.0244

THR 2298 MET 2299 0.0342

MET 2299 LEU 2300 0.0327

LEU 2300 ARG 2301 0.1158

ARG 2301 LEU 2302 0.0332

LEU 2302 LYS 2303 0.0340

LYS 2303 LYS 2304 0.0138

LYS 2304 ASP 2305 0.0247

ASP 2305 MET 2306 0.0333

MET 2306 LEU 2307 0.0340

LEU 2307 PRO 2308 0.0077

PRO 2308 ILE 2309 0.0194

ILE 2309 ARG 2310 0.0325

ARG 2310 GLY 2311 0.0274

GLY 2311 ILE 2312 0.0258

ILE 2312 VAL 2313 0.0326

VAL 2313 HIS 2314 0.0193

HIS 2314 ALA 2315 0.0335

ALA 2315 GLY 2316 0.0298

GLY 2316 MET 2317 -0.0714

MET 2317 VAL 2318 0.0171

VAL 2318 LEU 2319 0.0407

LEU 2319 GLN 2320 0.0029

GLN 2320 ASP 2321 0.0470

ASP 2321 SER 2322 0.0037

SER 2322 VAL 2323 0.0382

VAL 2323 PHE 2324 0.0440

PHE 2324 GLU 2325 0.0046

GLU 2325 ARG 2326 0.0479

ARG 2326 MET 2327 0.0274

MET 2327 SER 2328 0.0436

SER 2328 LEU 2329 0.0485

LEU 2329 ASP 2330 0.0334

ASP 2330 ASP 2331 0.0362

ASP 2331 TYR 2332 0.0492

TYR 2332 ASN 2333 0.1682

ASN 2333 THR 2334 0.0108

THR 2334 ALA 2335 0.0301

ALA 2335 ILE 2336 0.0304

ILE 2336 ARG 2337 0.0275

ARG 2337 PRO 2338 0.0027

PRO 2338 LYS 2339 0.0313

LYS 2339 VAL 2340 0.0150

VAL 2340 GLN 2341 0.0322

GLN 2341 GLY 2342 0.0012

GLY 2342 SER 2343 0.0314

SER 2343 TRP 2344 0.0224

TRP 2344 ASN 2345 0.0255

ASN 2345 LEU 2346 0.0078

LEU 2346 HIS 2347 0.0287

HIS 2347 SER 2348 0.0297

SER 2348 GLY 2349 0.0886

GLY 2349 LEU 2350 0.0206

LEU 2350 SER 2351 0.0278

SER 2351 ASP 2352 0.0118

ASP 2352 CYS 2353 0.0209

CYS 2353 ASP 2354 0.0295

ASP 2354 LEU 2355 0.0331

LEU 2355 ASP 2356 0.0269

ASP 2356 PHE 2357 0.0186

PHE 2357 PHE 2358 0.0118

PHE 2358 ILE 2359 0.0317

ILE 2359 MET 2360 0.0130

MET 2360 LEU 2361 0.0334

LEU 2361 SER 2362 0.0014

SER 2362 SER 2363 0.0287

SER 2363 LEU 2364 0.0286

LEU 2364 ALA 2365 -0.0180

ALA 2365 GLY 2366 0.0395

GLY 2366 VAL 2367 0.0377

VAL 2367 SER 2368 0.0397

SER 2368 GLY 2369 0.0126

GLY 2369 SER 2370 0.0418

SER 2370 ALA 2371 0.0120

ALA 2371 SER 2372 0.0367

SER 2372 GLN 2373 0.0271

GLN 2373 ALA 2374 0.0287

ALA 2374 ASN 2375 0.0404

ASN 2375 TYR 2376 0.0010

TYR 2376 THR 2377 0.0418

THR 2377 ALA 2378 0.0320

ALA 2378 GLY 2379 0.0243

GLY 2379 GLY 2380 0.0175

GLY 2380 ALA 2381 0.0468

ALA 2381 TYR 2382 0.0292

TYR 2382 GLN 2383 0.0002

GLN 2383 ASP 2384 0.0292

ASP 2384 ALA 2385 0.0192

ALA 2385 LEU 2386 0.0216

LEU 2386 ALA 2387 0.0084

ALA 2387 LYS 2388 0.0239

LYS 2388 TYR 2389 0.0255

TYR 2389 ARG 2390 0.0059

ARG 2390 ARG 2391 0.0238

ARG 2391 ALA 2392 0.0153

ALA 2392 GLN 2393 0.0273

GLN 2393 GLY 2394 0.0023

GLY 2394 LEU 2395 0.0277

LEU 2395 SER 2396 0.0216

SER 2396 ALA 2397 0.0313

ALA 2397 VAL 2398 0.0232

VAL 2398 SER 2399 0.0152

SER 2399 ILE 2400 0.0193

ILE 2400 ASP 2401 0.0115

ASP 2401 LEU 2402 0.0139

LEU 2402 GLY 2403 0.0227

GLY 2403 MET 2404 0.0212

MET 2404 VAL 2405 0.0025

VAL 2405 GLN 2406 0.0187

GLN 2406 SER 2407 0.0077

SER 2407 VAL 2408 0.0214

VAL 2408 GLY 2409 0.0084

GLY 2409 TYR 2410 0.0051

TYR 2410 VAL 2411 0.0231

VAL 2411 ALA 2412 0.0034

ALA 2412 GLU 2413 0.0750

GLU 2413 THR 2414 0.0035

THR 2414 LYS 2415 0.0252

LYS 2415 GLY 2416 0.0156

GLY 2416 VAL 2417 0.0256

VAL 2417 ALA 2418 0.0153

ALA 2418 GLU 2419 0.0204

GLU 2419 ARG 2420 0.0056

ARG 2420 LEU 2421 0.0228

LEU 2421 VAL 2422 0.0213

VAL 2422 ARG 2423 0.0063

ARG 2423 MET 2424 0.0208

MET 2424 GLY 2425 0.0163

GLY 2425 TYR 2426 0.0134

TYR 2426 SER 2427 0.0021

SER 2427 PRO 2428 0.0127

PRO 2428 ILE 2429 -0.0552

ILE 2429 SER 2430 0.0011

SER 2430 GLU 2431 0.0152

GLU 2431 MET 2432 0.0158

MET 2432 GLU 2433 0.0054

GLU 2433 VAL 2434 0.0180

VAL 2434 LEU 2435 0.0063

LEU 2435 LYS 2436 0.0201

LYS 2436 ILE 2437 0.0018

ILE 2437 VAL 2438 0.0188

VAL 2438 GLU 2439 0.0080

GLU 2439 HIS 2440 0.0132

HIS 2440 ALA 2441 0.0108

ALA 2441 ILE 2442 0.0094

ILE 2442 THR 2443 0.0168

THR 2443 ASN 2444 0.0065

ASN 2444 PRO 2445 0.2365

PRO 2445 PRO 2446 0.0131

PRO 2446 PRO 2447 0.0240

PRO 2447 GLU 2448 0.0015

GLU 2448 ALA 2449 0.0096

ALA 2449 SER 2450 0.0195

SER 2450 SER 2451 0.0102

SER 2451 ALA 2452 0.0240

ALA 2452 GLN 2453 0.0199

GLN 2453 ILE 2454 0.0179

ILE 2454 ILE 2455 0.0167

ILE 2455 THR 2456 0.0205

THR 2456 GLY 2457 0.0230

GLY 2457 ILE 2458 0.0173

ILE 2458 SER 2459 0.0232

SER 2459 THR 2460 0.0231

THR 2460 LYS 2461 -0.0483

LYS 2461 PRO 2462 0.0060

PRO 2462 GLY 2463 0.0036

GLY 2463 ARG 2464 0.0002

ARG 2464 HIS 2465 0.0097

HIS 2465 TRP 2466 0.0100

TRP 2466 THR 2467 0.0016

THR 2467 GLU 2468 0.0084

GLU 2468 SER 2469 0.0086

SER 2469 SER 2470 0.0061

SER 2470 TRP 2471 0.0053

TRP 2471 LEU 2472 0.0057

LEU 2472 GLN 2473 0.0053

GLN 2473 ASP 2474 0.0099

ASP 2474 ALA 2475 0.0082

ALA 2475 ARG 2476 0.0043

ARG 2476 PHE 2477 0.0542

PHE 2477 ALA 2478 0.0139

ALA 2478 THR 2479 0.0083

THR 2479 LEU 2480 0.0079

LEU 2480 ARG 2481 0.0092

ARG 2481 GLU 2482 0.0090

GLU 2482 ARG 2483 0.0147

ARG 2483 ALA 2484 0.0004

ALA 2484 ARG 2485 0.0152

ARG 2485 ASP 2486 0.0062

ASP 2486 VAL 2487 0.0114

VAL 2487 LYS 2488 0.0070

LYS 2488 GLU 2489 0.0106

GLU 2489 LEU 2490 0.0111

LEU 2490 SER 2491 0.0030

SER 2491 ASN 2492 0.0149

ASN 2492 SER 2493 0.1583

SER 2493 GLN 2494 0.0306

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** sdgklnrdh ***

CA strain for 22101813491974862

--- normal mode 17 ---

Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *