Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *

CA strain for 22101813491974862

--- normal mode 11 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
ASN 989 LYS 990 0.0383

LYS 990 ALA 991 0.0267

ALA 991 HIS 992 0.0219

HIS 992 ARG 993 0.0385

ARG 993 GLN 994 0.0389

GLN 994 ARG 995 0.0202

ARG 995 VAL 996 0.0274

VAL 996 HIS 997 0.0144

HIS 997 PRO 998 0.0262

PRO 998 PRO 999 0.0367

PRO 999 HIS 1000 0.0269

HIS 1000 ASP 1001 0.0116

ASP 1001 LEU 1002 0.0369

LEU 1002 LEU 1003 0.0002

LEU 1003 GLY 1004 0.0353

GLY 1004 SER 1005 -0.0172

SER 1005 LEU 1006 0.0126

LEU 1006 ILE 1007 0.0197

ILE 1007 VAL 1008 0.0167

VAL 1008 GLY 1009 0.0055

GLY 1009 ARG 1010 0.0355

ARG 1010 ASP 1011 0.0337

ASP 1011 LEU 1012 0.0216

LEU 1012 ARG 1013 0.0364

ARG 1013 GLU 1014 0.0307

GLU 1014 PRO 1015 0.0233

PRO 1015 THR 1016 0.0268

THR 1016 TRP 1017 0.0141

TRP 1017 ARG 1018 0.0345

ARG 1018 HIS 1019 0.0026

HIS 1019 PHE 1020 0.0305

PHE 1020 ILE 1021 0.0115

ILE 1021 ARG 1022 0.0252

ARG 1022 VAL 1023 0.0004

VAL 1023 GLN 1024 0.0355

GLN 1024 ASP 1025 0.0270

ASP 1025 ILE 1026 0.0279

ILE 1026 PRO 1027 0.0064

PRO 1027 TRP 1028 0.0309

TRP 1028 ILE 1029 0.0249

ILE 1029 ARG 1030 0.0198

ARG 1030 ASP 1031 0.0211

ASP 1031 HIS 1032 0.0246

HIS 1032 VAL 1033 0.0359

VAL 1033 VAL 1034 0.0342

VAL 1034 GLN 1035 0.0349

GLN 1035 SER 1036 0.0352

SER 1036 ALA 1037 0.0287

ALA 1037 LEU 1038 0.0346

LEU 1038 VAL 1039 0.0283

VAL 1039 TYR 1040 0.0289

TYR 1040 PRO 1041 0.0296

PRO 1041 GLY 1042 0.0264

GLY 1042 ALA 1043 0.0340

ALA 1043 GLY 1044 0.0268

GLY 1044 PHE 1045 0.0095

PHE 1045 ILE 1046 0.0356

ILE 1046 CYS 1047 0.0342

CYS 1047 MET 1048 0.0110

MET 1048 ALA 1049 0.0262

ALA 1049 MET 1050 0.0296

MET 1050 GLU 1051 0.0354

GLU 1051 ALA 1052 0.0042

ALA 1052 MET 1053 0.0479

MET 1053 VAL 1054 0.0337

VAL 1054 GLN 1055 0.0247

GLN 1055 LEU 1056 0.0164

LEU 1056 HIS 1057 0.0381

HIS 1057 GLU 1058 0.0391

GLU 1058 LEU 1059 0.0102

LEU 1059 ARG 1060 0.0302

ARG 1060 ASP 1061 0.0347

ASP 1061 SER 1062 0.0385

SER 1062 GLN 1063 0.0360

GLN 1063 SER 1064 0.0002

SER 1064 ARG 1065 0.0376

ARG 1065 LYS 1066 0.0002

LYS 1066 VAL 1067 0.0354

VAL 1067 ALA 1068 0.0242

ALA 1068 GLY 1069 0.0562

GLY 1069 TYR 1070 0.0322

TYR 1070 ARG 1071 0.0361

ARG 1071 LEU 1072 0.0365

LEU 1072 ALA 1073 0.0352

ALA 1073 GLU 1074 0.0363

GLU 1074 VAL 1075 0.0302

VAL 1075 ASP 1076 0.0369

ASP 1076 ILE 1077 0.0289

ILE 1077 LEU 1078 0.0265

LEU 1078 ARG 1079 0.0316

ARG 1079 ALA 1080 0.0186

ALA 1080 MET 1081 0.0325

MET 1081 LEU 1082 0.0300

LEU 1082 ILE 1083 0.0363

ILE 1083 PRO 1084 0.0370

PRO 1084 ASP 1085 0.0100

ASP 1085 THR 1086 0.0206

THR 1086 SER 1087 0.0317

SER 1087 GLU 1088 0.0095

GLU 1088 GLY 1089 0.0328

GLY 1089 LEU 1090 0.0273

LEU 1090 GLU 1091 0.0085

GLU 1091 ALA 1092 0.0378

ALA 1092 HIS 1093 0.0173

HIS 1093 ILE 1094 0.0381

ILE 1094 SER 1095 0.0087

SER 1095 LEU 1096 0.0367

LEU 1096 ARG 1097 0.0145

ARG 1097 PRO 1098 0.0351

PRO 1098 CYS 1099 0.0372

CYS 1099 SER 1100 0.0078

SER 1100 THR 1101 0.0437

THR 1101 LYS 1102 0.0399

LYS 1102 LEU 1103 0.0005

LEU 1103 LEU 1104 0.0391

LEU 1104 LEU 1105 0.0244

LEU 1105 THR 1106 0.0402

THR 1106 ASN 1107 0.0359

ASN 1107 GLU 1108 0.0358

GLU 1108 TRP 1109 0.0298

TRP 1109 TYR 1110 0.0403

TYR 1110 ASP 1111 0.0397

ASP 1111 PHE 1112 0.0271

PHE 1112 CYS 1113 0.0401

CYS 1113 VAL 1114 0.0231

VAL 1114 SER 1115 0.0382

SER 1115 SER 1116 0.0384

SER 1116 VAL 1117 0.0231

VAL 1117 GLY 1118 0.0344

GLY 1118 ASP 1119 0.0368

ASP 1119 ASP 1120 0.0138

ASP 1120 ASP 1121 0.0328

ASP 1121 LYS 1122 0.0377

LYS 1122 PHE 1123 0.0345

PHE 1123 VAL 1124 0.0134

VAL 1124 ASP 1125 0.0377

ASP 1125 HIS 1126 0.0030

HIS 1126 CYS 1127 0.0386

CYS 1127 ARG 1128 0.0223

ARG 1128 GLY 1129 0.0383

GLY 1129 ARG 1130 0.0340

ARG 1130 ILE 1131 0.0361

ILE 1131 THR 1132 0.0362

THR 1132 ILE 1133 0.0309

ILE 1133 GLU 1134 0.0404

GLU 1134 PHE 1135 0.0468

PHE 1135 ASP 1136 0.0356

ASP 1136 THR 1137 0.0389

THR 1137 SER 1138 0.0473

SER 1138 GLY 1139 0.0465

GLY 1139 SER 1140 0.0364

SER 1140 ALA 1141 0.0053

ALA 1141 ASP 1142 0.0295

ASP 1142 THR 1143 0.0484

THR 1143 PRO 1144 0.0007

PRO 1144 ARG 1145 0.0479

ARG 1145 THR 1146 0.0167

THR 1146 SER 1147 0.0168

SER 1147 LEU 1148 0.0403

LEU 1148 ARG 1149 -0.0485

ARG 1149 GLU 1150 0.0294

GLU 1150 ARG 1151 0.0287

ARG 1151 SER 1152 0.0103

SER 1152 ARG 1153 0.0222

ARG 1153 SER 1154 0.0320

SER 1154 THR 1155 0.0078

THR 1155 GLY 1156 0.0319

GLY 1156 LEU 1157 0.0238

LEU 1157 MET 1158 0.0250

MET 1158 ARG 1159 0.0316

ARG 1159 SER 1160 0.0319

SER 1160 VAL 1161 0.0226

VAL 1161 ASP 1162 0.0319

ASP 1162 PRO 1163 0.0033

PRO 1163 SER 1164 0.0316

SER 1164 ASN 1165 0.1035

ASN 1165 LEU 1166 0.0046

LEU 1166 TYR 1167 0.0304

TYR 1167 SER 1168 0.0248

SER 1168 PHE 1169 0.0314

PHE 1169 LEU 1170 0.0031

LEU 1170 ARG 1171 0.0348

ARG 1171 ALA 1172 0.0308

ALA 1172 GLN 1173 0.0128

GLN 1173 GLY 1174 0.0238

GLY 1174 ILE 1175 0.0344

ILE 1175 TYR 1176 0.0308

TYR 1176 HIS 1177 0.0353

HIS 1177 GLY 1178 0.0320

GLY 1178 PRO 1179 0.0256

PRO 1179 ILE 1180 0.0149

ILE 1180 PHE 1181 0.0147

PHE 1181 GLN 1182 0.0023

GLN 1182 ASN 1183 0.0327

ASN 1183 LEU 1184 0.0243

LEU 1184 LYS 1185 0.0070

LYS 1185 THR 1186 0.0287

THR 1186 ILE 1187 0.0312

ILE 1187 SER 1188 0.0291

SER 1188 SER 1189 0.0287

SER 1189 ARG 1190 0.0326

ARG 1190 LYS 1191 0.0255

LYS 1191 ASP 1192 0.0087

ASP 1192 HIS 1193 0.0327

HIS 1193 SER 1194 0.0294

SER 1194 GLU 1195 0.0322

GLU 1195 SER 1196 0.0324

SER 1196 SER 1197 0.0048

SER 1197 PHE 1198 0.0279

PHE 1198 VAL 1199 0.0331

VAL 1199 VAL 1200 0.0095

VAL 1200 ALA 1201 0.0340

ALA 1201 ASN 1202 0.0336

ASN 1202 THR 1203 0.0137

THR 1203 ALA 1204 0.0311

ALA 1204 SER 1205 0.0104

SER 1205 VAL 1206 0.0308

VAL 1206 MET 1207 0.0041

MET 1207 PRO 1208 0.0316

PRO 1208 ASN 1209 0.0323

ASN 1209 GLY 1210 0.0303

GLY 1210 PHE 1211 0.0034

PHE 1211 GLN 1212 0.0309

GLN 1212 SER 1213 0.0141

SER 1213 PRO 1214 0.0347

PRO 1214 HIS 1215 0.0352

HIS 1215 VAL 1216 0.0348

VAL 1216 ILE 1217 0.0185

ILE 1217 HIS 1218 0.0309

HIS 1218 PRO 1219 0.0349

PRO 1219 THR 1220 0.0010

THR 1220 THR 1221 0.0339

THR 1221 LEU 1222 0.0211

LEU 1222 ASP 1223 0.0308

ASP 1223 SER 1224 0.0052

SER 1224 ILE 1225 0.0314

ILE 1225 PHE 1226 0.0306

PHE 1226 GLN 1227 0.0075

GLN 1227 GLY 1228 0.0301

GLY 1228 ALA 1229 0.0010

ALA 1229 TYR 1230 0.0201

TYR 1230 THR 1231 0.0124

THR 1231 ALA 1232 0.0300

ALA 1232 LEU 1233 0.0320

LEU 1233 PRO 1234 0.0109

PRO 1234 GLY 1235 0.0163

GLY 1235 ALA 1236 0.0223

ALA 1236 GLY 1237 0.0214

GLY 1237 LEU 1238 0.0157

LEU 1238 ASP 1239 0.0316

ASP 1239 GLN 1240 0.0025

GLN 1240 ASN 1241 0.0291

ASN 1241 THR 1242 0.0109

THR 1242 ALA 1243 0.0272

ALA 1243 MET 1244 0.0226

MET 1244 ILE 1245 0.0336

ILE 1245 PRO 1246 0.0243

PRO 1246 ARG 1247 0.0120

ARG 1247 SER 1248 0.0296

SER 1248 ILE 1249 0.0349

ILE 1249 GLN 1250 0.0291

GLN 1250 GLU 1251 0.0352

GLU 1251 LEU 1252 0.0296

LEU 1252 TYR 1253 0.0353

TYR 1253 LEU 1254 0.0318

LEU 1254 SER 1255 0.0347

SER 1255 SER 1256 0.0328

SER 1256 ALA 1257 0.0068

ALA 1257 LEU 1258 0.0297

LEU 1258 THR 1259 0.0315

THR 1259 SER 1260 0.0352

SER 1260 ASP 1261 0.0030

ASP 1261 VAL 1262 0.0212

VAL 1262 GLY 1263 0.0092

GLY 1263 GLN 1264 0.0307

GLN 1264 CYS 1265 0.0269

CYS 1265 LEU 1266 0.0219

LEU 1266 VAL 1267 0.0297

VAL 1267 SER 1268 0.0251

SER 1268 ASP 1269 0.0332

ASP 1269 THR 1270 0.0293

THR 1270 SER 1271 0.0328

SER 1271 LEU 1272 0.0325

LEU 1272 ILE 1273 0.0126

ILE 1273 ARG 1274 0.0335

ARG 1274 TYR 1275 0.0266

TYR 1275 ASP 1276 0.0327

ASP 1276 GLY 1277 0.0319

GLY 1277 GLN 1278 0.0086

GLN 1278 SER 1279 0.0296

SER 1279 PHE 1280 0.0300

PHE 1280 THR 1281 0.0270

THR 1281 VAL 1282 0.0275

VAL 1282 ASN 1283 0.0321

ASN 1283 VAL 1284 0.0294

VAL 1284 ASP 1285 0.0329

ASP 1285 VAL 1286 0.0309

VAL 1286 SER 1287 0.0290

SER 1287 SER 1288 0.0282

SER 1288 LYS 1289 0.0000

LYS 1289 ALA 1290 0.0332

ALA 1290 ASP 1291 0.0233

ASP 1291 SER 1292 0.0228

SER 1292 GLU 1293 0.0282

GLU 1293 HIS 1294 0.0333

HIS 1294 THR 1295 0.0005

THR 1295 PRO 1296 0.0276

PRO 1296 VAL 1297 0.0270

VAL 1297 LEU 1298 0.0311

LEU 1298 GLU 1299 0.0328

GLU 1299 ILE 1300 0.0325

ILE 1300 LYS 1301 0.0316

LYS 1301 GLY 1302 0.0338

GLY 1302 LEU 1303 0.0310

LEU 1303 ARG 1304 0.0337

ARG 1304 ASN 1305 0.0259

ASN 1305 GLN 1306 0.0324

GLN 1306 SER 1307 0.0274

SER 1307 VAL 1308 0.0297

VAL 1308 GLY 1309 -0.0640

GLY 1309 GLN 1310 0.0044

GLN 1310 MET 1311 0.0014

MET 1311 ALA 1312 0.0031

ALA 1312 PRO 1313 0.0061

PRO 1313 GLN 1314 0.0017

GLN 1314 PRO 1315 0.0027

PRO 1315 GLY 1316 0.0062

GLY 1316 ASP 1317 0.0004

ASP 1317 SER 1318 0.0058

SER 1318 SER 1319 0.0032

SER 1319 ASN 1320 0.0048

ASN 1320 ASN 1321 0.0054

ASN 1321 ASP 1322 0.0046

ASP 1322 LEU 1323 0.0028

LEU 1323 CYS 1324 0.0060

CYS 1324 PHE 1325 0.0374

PHE 1325 LYS 1326 0.0050

LYS 1326 LEU 1327 0.0001

LEU 1327 ASP 1328 0.0124

ASP 1328 TRP 1329 0.0004

TRP 1329 ALA 1330 0.0122

ALA 1330 PRO 1331 0.0020

PRO 1331 ASP 1332 0.0119

ASP 1332 ILE 1333 0.0144

ILE 1333 SER 1334 0.0058

SER 1334 SER 1335 0.0104

SER 1335 VAL 1336 0.0132

VAL 1336 LYS 1337 0.0068

LYS 1337 GLN 1338 0.0142

GLN 1338 GLU 1339 0.0138

GLU 1339 ARG 1340 0.0058

ARG 1340 LEU 1341 -0.0617

LEU 1341 LYS 1342 0.0248

LYS 1342 GLU 1343 0.0298

GLU 1343 LYS 1344 0.0031

LYS 1344 PHE 1345 0.0247

PHE 1345 GLY 1346 0.0191

GLY 1346 PHE 1347 0.0263

PHE 1347 PRO 1348 0.0216

PRO 1348 LEU 1349 0.0298

LEU 1349 ASP 1350 0.0141

ASP 1350 PRO 1351 0.0259

PRO 1351 THR 1352 0.0059

THR 1352 GLU 1353 0.0300

GLU 1353 ALA 1354 0.0044

ALA 1354 ASP 1355 0.0268

ASP 1355 ILE 1356 0.0113

ILE 1356 ILE 1357 0.0355

ILE 1357 MET 1358 0.0222

MET 1358 GLY 1359 0.0086

GLY 1359 LEU 1360 0.0287

LEU 1360 ARG 1361 0.0060

ARG 1361 GLN 1362 0.0295

GLN 1362 ALA 1363 0.0048

ALA 1363 CYS 1364 0.0266

CYS 1364 ILE 1365 0.0148

ILE 1365 HIS 1366 0.0159

HIS 1366 PHE 1367 0.0206

PHE 1367 ILE 1368 0.0109

ILE 1368 HIS 1369 0.0262

HIS 1369 ARG 1370 0.0061

ARG 1370 SER 1371 0.0293

SER 1371 LEU 1372 0.0052

LEU 1372 GLN 1373 0.0272

GLN 1373 SER 1374 0.0060

SER 1374 LEU 1375 0.0277

LEU 1375 THR 1376 0.0296

THR 1376 ALA 1377 0.0192

ALA 1377 PRO 1378 0.0121

PRO 1378 ASP 1379 0.0267

ASP 1379 ARG 1380 0.0063

ARG 1380 ASP 1381 0.0300

ASP 1381 GLN 1382 0.0063

GLN 1382 LEU 1383 0.0277

LEU 1383 ASP 1384 0.0296

ASP 1384 TRP 1385 0.0092

TRP 1385 HIS 1386 0.0289

HIS 1386 GLN 1387 0.0284

GLN 1387 LYS 1388 0.0063

LYS 1388 ARG 1389 0.0275

ARG 1389 PHE 1390 0.0207

PHE 1390 TYR 1391 0.0277

TYR 1391 ASP 1392 0.0019

ASP 1392 TRP 1393 0.0291

TRP 1393 MET 1394 0.0235

MET 1394 VAL 1395 0.0121

VAL 1395 LEU 1396 0.0183

LEU 1396 GLN 1397 0.0214

GLN 1397 ILE 1398 0.0300

ILE 1398 GLN 1399 0.0006

GLN 1399 LEU 1400 0.0299

LEU 1400 ALA 1401 0.0209

ALA 1401 GLU 1402 0.0193

GLU 1402 GLU 1403 0.0111

GLU 1403 ASP 1404 0.0254

ASP 1404 ARG 1405 0.0270

ARG 1405 LEU 1406 0.0022

LEU 1406 ALA 1407 0.0301

ALA 1407 PRO 1408 0.0220

PRO 1408 ASN 1409 0.0282

ASN 1409 SER 1410 0.0204

SER 1410 SER 1411 0.0281

SER 1411 ALA 1412 0.0205

ALA 1412 TRP 1413 0.0114

TRP 1413 LEU 1414 0.0305

LEU 1414 GLN 1415 0.0300

GLN 1415 CYS 1416 0.0087

CYS 1416 SER 1417 0.0148

SER 1417 SER 1418 0.0070

SER 1418 SER 1419 0.0253

SER 1419 ASP 1420 0.0168

ASP 1420 GLU 1421 0.0323

GLU 1421 GLN 1422 0.0006

GLN 1422 LYS 1423 0.0303

LYS 1423 LEU 1424 0.0169

LEU 1424 LEU 1425 0.0193

LEU 1425 GLU 1426 0.0128

GLU 1426 ASN 1427 0.0212

ASN 1427 VAL 1428 0.0267

VAL 1428 ARG 1429 0.0049

ARG 1429 ALA 1430 0.0273

ALA 1430 SER 1431 0.0119

SER 1431 SER 1432 0.0305

SER 1432 VAL 1433 0.0254

VAL 1433 ASN 1434 0.0070

ASN 1434 GLY 1435 0.0302

GLY 1435 GLN 1436 0.0040

GLN 1436 MET 1437 0.0269

MET 1437 VAL 1438 0.0122

VAL 1438 VAL 1439 0.0204

VAL 1439 HIS 1440 0.0150

HIS 1440 VAL 1441 0.0187

VAL 1441 GLY 1442 0.0185

GLY 1442 LYS 1443 0.0155

LYS 1443 SER 1444 0.0283

SER 1444 MET 1445 0.0040

MET 1445 LEU 1446 0.0304

LEU 1446 ALA 1447 0.0062

ALA 1447 ILE 1448 0.0271

ILE 1448 LEU 1449 0.0099

LEU 1449 ARG 1450 0.0199

ARG 1450 HIS 1451 0.0212

HIS 1451 GLU 1452 0.0117

GLU 1452 ILE 1453 0.0287

ILE 1453 ALA 1454 0.0293

ALA 1454 PRO 1455 0.0205

PRO 1455 LEU 1456 0.0271

LEU 1456 GLU 1457 0.0031

GLU 1457 LEU 1458 0.0285

LEU 1458 MET 1459 0.0255

MET 1459 LEU 1460 0.0109

LEU 1460 GLN 1461 0.0201

GLN 1461 ASP 1462 0.0268

ASP 1462 LYS 1463 0.0239

LYS 1463 LEU 1464 0.0102

LEU 1464 LEU 1465 0.0205

LEU 1465 TYR 1466 0.0261

TYR 1466 ARG 1467 0.0301

ARG 1467 TYR 1468 0.0042

TYR 1468 TYR 1469 0.0217

TYR 1469 THR 1470 0.0236

THR 1470 ASP 1471 0.0271

ASP 1471 ALA 1472 0.0094

ALA 1472 ILE 1473 0.0096

ILE 1473 LYS 1474 0.0170

LYS 1474 TRP 1475 0.0164

TRP 1475 ASP 1476 0.0236

ASP 1476 ARG 1477 0.0045

ARG 1477 SER 1478 0.0262

SER 1478 TYR 1479 0.0065

TYR 1479 GLN 1480 0.0272

GLN 1480 GLN 1481 0.0056

GLN 1481 ILE 1482 0.0221

ILE 1482 ASP 1483 0.0138

ASP 1483 GLN 1484 0.0141

GLN 1484 LEU 1485 0.0215

LEU 1485 VAL 1486 0.0075

VAL 1486 LYS 1487 0.0203

LYS 1487 LEU 1488 0.0052

LEU 1488 HIS 1489 0.0226

HIS 1489 ALA 1490 0.0022

ALA 1490 HIS 1491 0.0216

HIS 1491 LYS 1492 0.0103

LYS 1492 CYS 1493 0.0171

CYS 1493 PRO 1494 0.0009

PRO 1494 THR 1495 0.0221

THR 1495 ALA 1496 0.0162

ALA 1496 LYS 1497 0.0212

LYS 1497 ILE 1498 0.0224

ILE 1498 ILE 1499 0.0226

ILE 1499 GLU 1500 0.0223

GLU 1500 ILE 1501 0.0310

ILE 1501 GLY 1502 0.0198

GLY 1502 ALA 1503 0.0153

ALA 1503 GLY 1504 0.0190

GLY 1504 THR 1505 0.0153

THR 1505 GLY 1506 0.0236

GLY 1506 GLY 1507 0.0187

GLY 1507 CYS 1508 0.0134

CYS 1508 THR 1509 0.0144

THR 1509 ARG 1510 0.0186

ARG 1510 ALA 1511 0.0091

ALA 1511 VAL 1512 0.0231

VAL 1512 LEU 1513 0.0044

LEU 1513 ASP 1514 0.0245

ASP 1514 ALA 1515 0.0054

ALA 1515 LEU 1516 0.0227

LEU 1516 SER 1517 0.0047

SER 1517 ASN 1518 0.0230

ASN 1518 GLN 1519 0.0044

GLN 1519 GLY 1520 0.0192

GLY 1520 ILE 1521 0.0181

ILE 1521 ALA 1522 0.0132

ALA 1522 ARG 1523 0.0041

ARG 1523 CYS 1524 0.0220

CYS 1524 ALA 1525 0.0215

ALA 1525 GLN 1526 0.0227

GLN 1526 TYR 1527 0.0226

TYR 1527 ASP 1528 0.0227

ASP 1528 PHE 1529 0.0216

PHE 1529 THR 1530 0.0194

THR 1530 ASP 1531 0.0230

ASP 1531 VAL 1532 0.0220

VAL 1532 SER 1533 0.0238

SER 1533 SER 1534 0.0069

SER 1534 GLY 1535 0.0231

GLY 1535 PHE 1536 0.0257

PHE 1536 PHE 1537 0.0234

PHE 1537 GLU 1538 0.0019

GLU 1538 ALA 1539 0.0248

ALA 1539 ALA 1540 0.0154

ALA 1540 GLN 1541 0.0152

GLN 1541 GLN 1542 0.0150

GLN 1542 LYS 1543 0.0131

LYS 1543 PHE 1544 0.0235

PHE 1544 ALA 1545 0.0079

ALA 1545 ALA 1546 0.0253

ALA 1546 PHE 1547 0.0115

PHE 1547 ASP 1548 0.0209

ASP 1548 ASP 1549 0.0511

ASP 1549 VAL 1550 0.0012

VAL 1550 ILE 1551 0.0264

ILE 1551 ARG 1552 0.0262

ARG 1552 PHE 1553 0.0264

PHE 1553 GLN 1554 0.0197

GLN 1554 LYS 1555 0.0215

LYS 1555 LEU 1556 0.0000

LEU 1556 ASP 1557 0.0163

ASP 1557 ILE 1558 0.0055

ILE 1558 GLU 1559 0.0200

GLU 1559 LYS 1560 0.0214

LYS 1560 ASP 1561 0.0252

ASP 1561 ILE 1562 0.0214

ILE 1562 GLU 1563 0.0244

GLU 1563 MET 1564 0.0206

MET 1564 GLN 1565 0.0235

GLN 1565 GLY 1566 0.0235

GLY 1566 PHE 1567 0.0169

PHE 1567 GLU 1568 0.0194

GLU 1568 CYS 1569 0.0005

CYS 1569 GLY 1570 0.0214

GLY 1570 SER 1571 0.0056

SER 1571 TYR 1572 0.0263

TYR 1572 ASP 1573 0.0220

ASP 1573 LEU 1574 0.0257

LEU 1574 VAL 1575 0.0260

VAL 1575 ILE 1576 0.0237

ILE 1576 ALA 1577 0.0253

ALA 1577 SER 1578 0.0249

SER 1578 GLN 1579 0.0249

GLN 1579 VAL 1580 0.0258

VAL 1580 LEU 1581 -0.0039

LEU 1581 HIS 1582 0.0225

HIS 1582 ALA 1583 0.0153

ALA 1583 THR 1584 0.0209

THR 1584 GLY 1585 0.0169

GLY 1585 LYS 1586 0.0119

LYS 1586 MET 1587 0.0264

MET 1587 GLU 1588 0.0181

GLU 1588 HIS 1589 0.0136

HIS 1589 THR 1590 0.0122

THR 1590 MET 1591 0.0200

MET 1591 ALA 1592 0.0252

ALA 1592 ASN 1593 0.0006

ASN 1593 VAL 1594 0.0259

VAL 1594 ARG 1595 0.0150

ARG 1595 LYS 1596 0.0197

LYS 1596 LEU 1597 0.0130

LEU 1597 LEU 1598 0.0202

LEU 1598 LYS 1599 0.0250

LYS 1599 PRO 1600 0.0022

PRO 1600 GLY 1601 0.0263

GLY 1601 GLY 1602 0.0079

GLY 1602 LYS 1603 0.0261

LYS 1603 LEU 1604 0.0263

LEU 1604 LEU 1605 0.0225

LEU 1605 LEU 1606 0.0259

LEU 1606 VAL 1607 0.0237

VAL 1607 GLU 1608 0.0212

GLU 1608 THR 1609 0.0242

THR 1609 THR 1610 0.0009

THR 1610 ARG 1611 0.0260

ARG 1611 ASP 1612 0.0179

ASP 1612 GLU 1613 0.0652

GLU 1613 MET 1614 0.0273

MET 1614 ASP 1615 0.0011

ASP 1615 LEU 1616 0.0292

LEU 1616 GLN 1617 0.0211

GLN 1617 LEU 1618 0.0211

LEU 1618 VAL 1619 0.0073

VAL 1619 PHE 1620 0.0279

PHE 1620 GLY 1621 0.0158

GLY 1621 LEU 1622 0.0125

LEU 1622 LEU 1623 0.0278

LEU 1623 PRO 1624 0.0237

PRO 1624 GLY 1625 0.0289

GLY 1625 TRP 1626 0.0173

TRP 1626 TRP 1627 0.0170

TRP 1627 LEU 1628 0.0291

LEU 1628 SER 1629 -0.0026

SER 1629 SER 1630 0.0166

SER 1630 GLU 1631 0.0146

GLU 1631 GLU 1632 0.0178

GLU 1632 GLU 1633 0.0301

GLU 1633 ARG 1634 -0.0000

ARG 1634 GLN 1635 0.0297

GLN 1635 MET 1636 0.0298

MET 1636 SER 1637 0.0227

SER 1637 PRO 1638 0.0224

PRO 1638 SER 1639 0.0261

SER 1639 LEU 1640 0.0118

LEU 1640 SER 1641 0.0196

SER 1641 THR 1642 0.0302

THR 1642 ASN 1643 0.0042

ASN 1643 SER 1644 0.0265

SER 1644 TRP 1645 0.0171

TRP 1645 GLU 1646 0.0138

GLU 1646 LYS 1647 0.0189

LYS 1647 VAL 1648 0.0083

VAL 1648 LEU 1649 0.0218

LEU 1649 LYS 1650 0.0061

LYS 1650 LYS 1651 0.0250

LYS 1651 THR 1652 0.0029

THR 1652 GLY 1653 0.0248

GLY 1653 PHE 1654 0.0243

PHE 1654 ASP 1655 0.0135

ASP 1655 GLY 1656 0.0247

GLY 1656 LEU 1657 0.0191

LEU 1657 ASP 1658 0.0237

ASP 1658 ILE 1659 0.0199

ILE 1659 GLU 1660 0.0249

GLU 1660 LEU 1661 0.0247

LEU 1661 ARG 1662 0.0283

ARG 1662 ASP 1663 0.0093

ASP 1663 CYS 1664 0.0192

CYS 1664 ASP 1665 0.0050

ASP 1665 SER 1666 0.0252

SER 1666 ASP 1667 0.0163

ASP 1667 GLU 1668 0.0241

GLU 1668 PHE 1669 0.0010

PHE 1669 TYR 1670 0.0277

TYR 1670 SER 1671 0.0231

SER 1671 PHE 1672 0.0242

PHE 1672 SER 1673 0.0229

SER 1673 VAL 1674 0.0214

VAL 1674 MET 1675 0.0178

MET 1675 MET 1676 0.0281

MET 1676 ALA 1677 0.0826

ALA 1677 THR 1678 0.0139

THR 1678 ALA 1679 0.0137

ALA 1679 SER 1680 0.0050

SER 1680 SER 1681 0.0135

SER 1681 THR 1682 0.0083

THR 1682 ILE 1683 0.0142

ILE 1683 ALA 1684 0.0140

ALA 1684 SER 1685 0.0079

SER 1685 SER 1686 0.0103

SER 1686 SER 1687 0.0102

SER 1687 MET 1688 0.0083

MET 1688 ALA 1689 0.0131

ALA 1689 PHE 1690 0.0129

PHE 1690 ALA 1691 0.0138

ALA 1691 ILE 1692 0.0138

ILE 1692 VAL 1693 -0.0037

VAL 1693 TYR 1694 0.0087

TYR 1694 GLY 1695 0.0047

GLY 1695 GLU 1696 0.0084

GLU 1696 VAL 1697 0.0056

VAL 1697 PRO 1698 0.0028

PRO 1698 LEU 1699 0.0085

LEU 1699 PRO 1700 0.0028

PRO 1700 ASP 1701 0.0030

ASP 1701 GLN 1702 0.0082

GLN 1702 PHE 1703 0.0016

PHE 1703 LEU 1704 0.0085

LEU 1704 ASP 1705 0.0017

ASP 1705 ASP 1706 0.0080

ASP 1706 MET 1707 0.0029

MET 1707 LYS 1708 0.0063

LYS 1708 THR 1709 0.0159

THR 1709 ALA 1710 0.0041

ALA 1710 ILE 1711 0.0077

ILE 1711 SER 1712 0.0028

SER 1712 SER 1713 0.0098

SER 1713 SER 1714 0.0022

SER 1714 ALA 1715 0.0096

ALA 1715 VAL 1716 0.0065

VAL 1716 SER 1717 0.0097

SER 1717 ASP 1718 0.0095

ASP 1718 PRO 1719 0.0031

PRO 1719 VAL 1720 0.0098

VAL 1720 VAL 1721 0.0095

VAL 1721 GLY 1722 0.0069

GLY 1722 HIS 1723 0.0051

HIS 1723 LEU 1724 0.0014

LEU 1724 ASP 1725 0.0176

ASP 1725 SER 1726 0.0023

SER 1726 ILE 1727 0.0080

ILE 1727 ASP 1728 0.0077

ASP 1728 ALA 1729 0.0056

ALA 1729 THR 1730 0.0079

THR 1730 GLY 1731 0.0078

GLY 1731 LYS 1732 0.0068

LYS 1732 PHE 1733 0.0069

PHE 1733 CYS 1734 0.0080

CYS 1734 ILE 1735 0.0079

ILE 1735 PHE 1736 0.0062

PHE 1736 ILE 1737 0.0075

ILE 1737 GLU 1738 0.0054

GLU 1738 ASP 1739 0.0074

ASP 1739 PRO 1740 0.0053

PRO 1740 GLU 1741 -0.0195

GLU 1741 THR 1742 0.0049

THR 1742 ASP 1743 0.0019

ASP 1743 ILE 1744 0.0060

ILE 1744 LEU 1745 0.0015

LEU 1745 SER 1746 0.0050

SER 1746 SER 1747 0.0062

SER 1747 PRO 1748 0.0048

PRO 1748 ASP 1749 0.0061

ASP 1749 GLU 1750 0.0060

GLU 1750 LYS 1751 0.0005

LYS 1751 SER 1752 0.0061

SER 1752 TYR 1753 0.0019

TYR 1753 ALA 1754 0.0057

ALA 1754 SER 1755 0.0010

SER 1755 ILE 1756 0.0052

ILE 1756 GLN 1757 0.0063

GLN 1757 LYS 1758 0.0021

LYS 1758 LEU 1759 0.0055

LEU 1759 VAL 1760 0.0027

VAL 1760 THR 1761 0.0064

THR 1761 ARG 1762 0.0005

ARG 1762 CYS 1763 0.0056

CYS 1763 LYS 1764 0.0067

LYS 1764 GLY 1765 0.0061

GLY 1765 LEU 1766 0.0066

LEU 1766 ILE 1767 0.0064

ILE 1767 TRP 1768 0.0057

TRP 1768 VAL 1769 0.0056

VAL 1769 SER 1770 0.0049

SER 1770 ARG 1771 0.0066

ARG 1771 GLY 1772 0.0024

GLY 1772 GLY 1773 0.0129

GLY 1773 ALA 1774 0.0045

ALA 1774 MET 1775 0.0045

MET 1775 HIS 1776 0.0045

HIS 1776 GLY 1777 0.0044

GLY 1777 THR 1778 0.0035

THR 1778 ARG 1779 0.0046

ARG 1779 PRO 1780 0.0013

PRO 1780 ASN 1781 0.0043

ASN 1781 SER 1782 0.0022

SER 1782 SER 1783 0.0023

SER 1783 LEU 1784 0.0042

LEU 1784 LYS 1785 0.0022

LYS 1785 THR 1786 0.0043

THR 1786 GLY 1787 0.0008

GLY 1787 LEU 1788 0.0039

LEU 1788 LEU 1789 0.0089

LEU 1789 ARG 1790 0.0019

ARG 1790 THR 1791 0.0046

THR 1791 LEU 1792 0.0016

LEU 1792 ARG 1793 0.0056

ARG 1793 LEU 1794 0.0014

LEU 1794 GLU 1795 0.0052

GLU 1795 TYR 1796 0.0013

TYR 1796 THR 1797 0.0055

THR 1797 GLU 1798 0.0012

GLU 1798 LYS 1799 0.0040

LYS 1799 ARG 1800 0.0052

ARG 1800 PHE 1801 0.0049

PHE 1801 ILE 1802 0.0051

ILE 1802 SER 1803 0.0053

SER 1803 LEU 1804 0.0029

LEU 1804 ASP 1805 0.0267

ASP 1805 LEU 1806 0.0030

LEU 1806 ASP 1807 0.0079

ASP 1807 SER 1808 0.0079

SER 1808 ALA 1809 0.0071

ALA 1809 ARG 1810 0.0015

ARG 1810 PRO 1811 0.0039

PRO 1811 GLN 1812 0.0080

GLN 1812 TRP 1813 0.0028

TRP 1813 ASN 1814 0.0073

ASN 1814 HIS 1815 0.0069

HIS 1815 ASP 1816 0.0023

ASP 1816 SER 1817 0.0058

SER 1817 ILE 1818 0.0049

ILE 1818 THR 1819 0.0080

THR 1819 THR 1820 -0.0000

THR 1820 ILE 1821 0.0156

ILE 1821 ASN 1822 0.0078

ASN 1822 GLU 1823 0.0073

GLU 1823 VAL 1824 0.0048

VAL 1824 LEU 1825 0.0080

LEU 1825 CYS 1826 0.0108

CYS 1826 GLY 1827 0.0010

GLY 1827 ALA 1828 0.0113

ALA 1828 LEU 1829 0.0059

LEU 1829 ALA 1830 0.0116

ALA 1830 GLN 1831 0.0013

GLN 1831 ASN 1832 0.0117

ASN 1832 ALA 1833 0.0038

ALA 1833 ASP 1834 0.0070

ASP 1834 SER 1835 0.0111

SER 1835 SER 1836 0.0024

SER 1836 ILE 1837 -0.0122

ILE 1837 LYS 1838 0.0047

LYS 1838 ASP 1839 0.0095

ASP 1839 SER 1840 0.0094

SER 1840 GLU 1841 0.0093

GLU 1841 PHE 1842 0.0059

PHE 1842 ALA 1843 0.0094

ALA 1843 GLU 1844 0.0043

GLU 1844 GLN 1845 0.0089

GLN 1845 ASP 1846 0.0054

ASP 1846 GLY 1847 0.0061

GLY 1847 GLN 1848 0.0051

GLN 1848 LEU 1849 0.0077

LEU 1849 PHE 1850 0.0000

PHE 1850 VAL 1851 0.0057

VAL 1851 PRO 1852 0.0010

PRO 1852 ARG 1853 0.0080

ARG 1853 ILE 1854 0.0020

ILE 1854 SER 1855 0.0015

SER 1855 CYS 1856 0.0019

CYS 1856 ASP 1857 0.0010

ASP 1857 ILE 1858 0.0015

ILE 1858 ALA 1859 0.0011

ALA 1859 ARG 1860 0.0008

ARG 1860 ASN 1861 0.0014

ASN 1861 GLU 1862 0.0017

GLU 1862 ASP 1863 0.0002

ASP 1863 LEU 1864 0.0021

LEU 1864 SER 1865 0.0008

SER 1865 SER 1866 0.0019

SER 1866 ASP 1867 0.0015

ASP 1867 SER 1868 0.0005

SER 1868 ASN 1869 0.0437

ASN 1869 SER 1870 0.0408

SER 1870 PRO 1871 0.0492

PRO 1871 ALA 1872 0.0533

ALA 1872 GLN 1873 0.0371

GLN 1873 MET 1874 0.0508

MET 1874 GLU 1875 0.0472

GLU 1875 PRO 1876 0.0555

PRO 1876 PHE 1877 0.0311

PHE 1877 HIS 1878 0.0442

HIS 1878 GLN 1879 0.0130

GLN 1879 PRO 1880 0.0412

PRO 1880 GLY 1881 0.0562

GLY 1881 LYS 1882 0.0435

LYS 1882 LEU 1883 0.0099

LEU 1883 LEU 1884 0.0373

LEU 1884 GLN 1885 0.0327

GLN 1885 MET 1886 0.0271

MET 1886 GLY 1887 0.0445

GLY 1887 ILE 1888 0.0399

ILE 1888 LYS 1889 0.0401

LYS 1889 THR 1890 0.0154

THR 1890 PRO 1891 0.0126

PRO 1891 GLY 1892 0.0306

GLY 1892 LEU 1893 0.0284

LEU 1893 ILE 1894 0.0511

ILE 1894 ASP 1895 0.0224

ASP 1895 THR 1896 0.0369

THR 1896 LEU 1897 0.0511

LEU 1897 GLN 1898 0.0045

GLN 1898 PHE 1899 0.0340

PHE 1899 SER 1900 0.0324

SER 1900 LYS 1901 0.0378

LYS 1901 THR 1902 0.0593

THR 1902 ASP 1903 0.0387

ASP 1903 ALA 1904 0.0604

ALA 1904 THR 1905 0.0607

THR 1905 ASP 1906 0.0514

ASP 1906 ASN 1907 0.0417

ASN 1907 LEU 1908 0.0160

LEU 1908 PRO 1909 0.0386

PRO 1909 ASN 1910 0.0576

ASN 1910 ASP 1911 0.0062

ASP 1911 TYR 1912 0.0586

TYR 1912 ILE 1913 0.0592

ILE 1913 GLU 1914 0.0445

GLU 1914 ILE 1915 0.0519

ILE 1915 GLU 1916 0.0514

GLU 1916 PRO 1917 0.0282

PRO 1917 LYS 1918 0.0519

LYS 1918 ALA 1919 0.0144

ALA 1919 PHE 1920 0.0390

PHE 1920 GLY 1921 0.0036

GLY 1921 LEU 1922 0.0511

LEU 1922 ASN 1923 0.0248

ASN 1923 PHE 1924 0.0348

PHE 1924 ARG 1925 0.0460

ARG 1925 ASP 1926 0.0086

ASP 1926 VAL 1927 0.0466

VAL 1927 MET 1928 0.0412

MET 1928 VAL 1929 0.0145

VAL 1929 ALA 1930 0.0397

ALA 1930 MET 1931 0.0278

MET 1931 GLY 1932 0.0528

GLY 1932 GLN 1933 -0.0158

GLN 1933 LEU 1934 0.0518

LEU 1934 GLU 1935 0.0433

GLU 1935 GLU 1936 0.0363

GLU 1936 SER 1937 0.0193

SER 1937 ILE 1938 0.0524

ILE 1938 MET 1939 0.0529

MET 1939 GLY 1940 0.0524

GLY 1940 PHE 1941 0.0326

PHE 1941 GLU 1942 0.0522

GLU 1942 CYS 1943 0.0304

CYS 1943 ALA 1944 0.0508

ALA 1944 GLY 1945 0.0074

GLY 1945 VAL 1946 0.0311

VAL 1946 VAL 1947 0.0504

VAL 1947 ARG 1948 0.0041

ARG 1948 ARG 1949 0.0675

ARG 1949 VAL 1950 0.0418

VAL 1950 GLY 1951 0.0599

GLY 1951 PRO 1952 0.0588

PRO 1952 SER 1953 0.0072

SER 1953 SER 1954 0.0520

SER 1954 ALA 1955 0.0485

ALA 1955 GLY 1956 0.0368

GLY 1956 HIS 1957 0.0243

HIS 1957 ASN 1958 0.0583

ASN 1958 ILE 1959 0.0481

ILE 1959 LYS 1960 0.0114

LYS 1960 VAL 1961 0.0319

VAL 1961 GLY 1962 0.0574

GLY 1962 ASP 1963 0.0013

ASP 1963 ARG 1964 0.0411

ARG 1964 VAL 1965 0.0402

VAL 1965 CYS 1966 0.0341

CYS 1966 ALA 1967 0.0572

ALA 1967 LEU 1968 0.0422

LEU 1968 LEU 1969 0.0351

LEU 1969 GLY 1970 0.0571

GLY 1970 GLY 1971 0.0572

GLY 1971 GLN 1972 0.0149

GLN 1972 TRP 1973 0.0547

TRP 1973 THR 1974 0.0107

THR 1974 ASN 1975 0.0357

ASN 1975 THR 1976 0.0573

THR 1976 VAL 1977 0.0213

VAL 1977 ARG 1978 0.0573

ARG 1978 VAL 1979 0.0144

VAL 1979 HIS 1980 0.0502

HIS 1980 TRP 1981 0.0664

TRP 1981 HIS 1982 0.0018

HIS 1982 SER 1983 0.0585

SER 1983 VAL 1984 0.0499

VAL 1984 ALA 1985 0.0490

ALA 1985 PRO 1986 0.0498

PRO 1986 ILE 1987 0.0542

ILE 1987 PRO 1988 0.0561

PRO 1988 GLN 1989 0.0235

GLN 1989 ALA 1990 0.0433

ALA 1990 MET 1991 0.0554

MET 1991 ASP 1992 0.0437

ASP 1992 TRP 1993 0.0515

TRP 1993 GLU 1994 0.0362

GLU 1994 THR 1995 0.0199

THR 1995 ALA 1996 0.0497

ALA 1996 ALA 1997 0.0503

ALA 1997 SER 1998 0.0090

SER 1998 ILE 1999 0.0456

ILE 1999 PRO 2000 0.0506

PRO 2000 ILE 2001 0.0476

ILE 2001 VAL 2002 0.0194

VAL 2002 PHE 2003 0.0500

PHE 2003 VAL 2004 0.0517

VAL 2004 THR 2005 0.0428

THR 2005 ALA 2006 0.0206

ALA 2006 TYR 2007 0.0551

TYR 2007 ILE 2008 0.0544

ILE 2008 SER 2009 0.0276

SER 2009 LEU 2010 0.0296

LEU 2010 VAL 2011 0.0531

VAL 2011 LYS 2012 0.0467

LYS 2012 ILE 2013 0.0571

ILE 2013 ALA 2014 0.0143

ALA 2014 ARG 2015 0.0533

ARG 2015 MET 2016 0.0395

MET 2016 GLN 2017 0.0327

GLN 2017 ALA 2018 0.0449

ALA 2018 GLY 2019 0.0210

GLY 2019 GLU 2020 0.0493

GLU 2020 THR 2021 0.0536

THR 2021 VAL 2022 0.0149

VAL 2022 LEU 2023 0.0509

LEU 2023 ILE 2024 0.0070

ILE 2024 HIS 2025 0.0461

HIS 2025 ALA 2026 0.0286

ALA 2026 ALA 2027 0.0504

ALA 2027 SER 2028 0.0373

SER 2028 GLY 2029 0.0214

GLY 2029 GLY 2030 0.0398

GLY 2030 VAL 2031 0.0452

VAL 2031 GLY 2032 0.0108

GLY 2032 GLN 2033 0.0541

GLN 2033 ALA 2034 0.0480

ALA 2034 ALA 2035 0.0200

ALA 2035 ILE 2036 0.0363

ILE 2036 ILE 2037 0.0431

ILE 2037 LEU 2038 0.0550

LEU 2038 ALA 2039 0.0060

ALA 2039 LYS 2040 0.0525

LYS 2040 HIS 2041 0.0424

HIS 2041 VAL 2042 0.0396

VAL 2042 GLY 2043 0.0181

GLY 2043 ALA 2044 0.0526

ALA 2044 GLU 2045 0.0134

GLU 2045 ILE 2046 0.0377

ILE 2046 PHE 2047 0.0542

PHE 2047 ALA 2048 0.0242

ALA 2048 THR 2049 0.0508

THR 2049 VAL 2050 0.0344

VAL 2050 GLY 2051 0.0492

GLY 2051 THR 2052 0.0548

THR 2052 ASP 2053 0.0418

ASP 2053 GLU 2054 0.0199

GLU 2054 LYS 2055 0.0551

LYS 2055 ARG 2056 0.0029

ARG 2056 ASP 2057 0.0545

ASP 2057 LEU 2058 0.0269

LEU 2058 LEU 2059 0.0365

LEU 2059 ILE 2060 0.0271

ILE 2060 LYS 2061 0.0413

LYS 2061 GLU 2062 0.0308

GLU 2062 TYR 2063 0.0436

TYR 2063 LYS 2064 0.0070

LYS 2064 ILE 2065 0.0498

ILE 2065 PRO 2066 0.0116

PRO 2066 ASP 2067 0.0559

ASP 2067 ASP 2068 0.0283

ASP 2068 HIS 2069 0.0342

HIS 2069 ILE 2070 0.0276

ILE 2070 PHE 2071 0.0560

PHE 2071 SER 2072 0.0389

SER 2072 SER 2073 0.0305

SER 2073 ARG 2074 0.0559

ARG 2074 ASN 2075 0.0097

ASN 2075 ALA 2076 0.0377

ALA 2076 LEU 2077 0.0319

LEU 2077 PHE 2078 0.0470

PHE 2078 ALA 2079 0.0464

ALA 2079 LYS 2080 0.0058

LYS 2080 SER 2081 0.0513

SER 2081 ILE 2082 0.0452

ILE 2082 ARG 2083 0.0265

ARG 2083 GLN 2084 0.0263

GLN 2084 ARG 2085 0.0446

ARG 2085 THR 2086 0.0511

THR 2086 ASN 2087 0.0052

ASN 2087 GLY 2088 0.0461

GLY 2088 LYS 2089 0.0366

LYS 2089 GLY 2090 0.0108

GLY 2090 VAL 2091 0.0178

VAL 2091 ASP 2092 0.0464

ASP 2092 VAL 2093 -0.0169

VAL 2093 VAL 2094 0.0391

VAL 2094 LEU 2095 0.0041

LEU 2095 ASN 2096 0.0486

ASN 2096 CYS 2097 0.0184

CYS 2097 LEU 2098 0.0416

LEU 2098 ALA 2099 0.0501

ALA 2099 GLY 2100 0.0362

GLY 2100 GLY 2101 0.0032

GLY 2101 LEU 2102 0.0517

LEU 2102 LEU 2103 0.0483

LEU 2103 GLN 2104 0.0183

GLN 2104 GLU 2105 0.0340

GLU 2105 SER 2106 0.0439

SER 2106 PHE 2107 0.0498

PHE 2107 ASP 2108 0.0061

ASP 2108 CYS 2109 0.0446

CYS 2109 LEU 2110 0.0458

LEU 2110 ALA 2111 0.0225

ALA 2111 ASP 2112 0.0433

ASP 2112 PHE 2113 0.0249

PHE 2113 GLY 2114 0.0309

GLY 2114 ARG 2115 0.0002

ARG 2115 PHE 2116 0.0339

PHE 2116 ILE 2117 0.0042

ILE 2117 GLU 2118 0.0301

GLU 2118 ILE 2119 0.0122

ILE 2119 GLY 2120 0.0460

GLY 2120 LYS 2121 0.0282

LYS 2121 ARG 2122 0.0468

ARG 2122 ASP 2123 0.0175

ASP 2123 ILE 2124 0.0418

ILE 2124 GLU 2125 0.0139

GLU 2125 LEU 2126 0.0373

LEU 2126 ASN 2127 0.0305

ASN 2127 HIS 2128 0.0160

HIS 2128 CYS 2129 0.0106

CYS 2129 LEU 2130 0.0303

LEU 2130 ASN 2131 0.0012

ASN 2131 MET 2132 0.0451

MET 2132 GLY 2133 0.0048

GLY 2133 MET 2134 0.0466

MET 2134 PHE 2135 0.0456

PHE 2135 ALA 2136 0.0040

ALA 2136 ARG 2137 0.0467

ARG 2137 SER 2138 0.0292

SER 2138 ALA 2139 0.0287

ALA 2139 THR 2140 0.0047

THR 2140 PHE 2141 0.0231

PHE 2141 THR 2142 0.0081

THR 2142 ALA 2143 0.0136

ALA 2143 VAL 2144 0.0301

VAL 2144 ASP 2145 0.0023

ASP 2145 LEU 2146 0.0341

LEU 2146 ILE 2147 0.0176

ILE 2147 ALA 2148 0.0433

ALA 2148 ILE 2149 0.0459

ILE 2149 GLY 2150 0.0097

GLY 2150 ARG 2151 0.0420

ARG 2151 ASP 2152 0.0309

ASP 2152 ARG 2153 0.0375

ARG 2153 SER 2154 0.0331

SER 2154 TYR 2155 0.0415

TYR 2155 MET 2156 0.0237

MET 2156 PHE 2157 0.0221

PHE 2157 ALA 2158 0.0494

ALA 2158 GLU 2159 0.0065

GLU 2159 ALA 2160 0.0510

ALA 2160 LEU 2161 0.0241

LEU 2161 PRO 2162 0.0544

PRO 2162 LYS 2163 0.0023

LYS 2163 ILE 2164 0.0560

ILE 2164 MET 2165 0.0235

MET 2165 THR 2166 0.0453

THR 2166 LEU 2167 0.0178

LEU 2167 LEU 2168 0.0409

LEU 2168 GLN 2169 0.0433

GLN 2169 GLU 2170 0.0152

GLU 2170 LYS 2171 0.0505

LYS 2171 ALA 2172 0.0235

ALA 2172 ILE 2173 0.0625

ILE 2173 ARG 2174 0.0416

ARG 2174 PRO 2175 0.0340

PRO 2175 VAL 2176 0.0503

VAL 2176 THR 2177 0.0545

THR 2177 PRO 2178 0.0414

PRO 2178 ILE 2179 0.0116

ILE 2179 SER 2180 0.0444

SER 2180 ILE 2181 0.0012

ILE 2181 TYR 2182 0.0328

TYR 2182 LYS 2183 0.0012

LYS 2183 ILE 2184 0.0488

ILE 2184 GLY 2185 0.0433

GLY 2185 ASP 2186 0.0120

ASP 2186 ILE 2187 0.0458

ILE 2187 GLU 2188 0.0510

GLU 2188 THR 2189 0.0687

THR 2189 ALA 2190 0.0440

ALA 2190 PHE 2191 0.0525

PHE 2191 ARG 2192 0.0461

ARG 2192 LEU 2193 0.0355

LEU 2193 MET 2194 0.0480

MET 2194 GLN 2195 0.0532

GLN 2195 ALA 2196 0.0379

ALA 2196 GLY 2197 0.0367

GLY 2197 LYS 2198 0.0537

LYS 2198 HIS 2199 0.0473

HIS 2199 MET 2200 0.0389

MET 2200 GLY 2201 0.0505

GLY 2201 LYS 2202 0.0094

LYS 2202 ILE 2203 0.0155

ILE 2203 VAL 2204 0.0188

VAL 2204 ILE 2205 0.0443

ILE 2205 THR 2206 0.0274

THR 2206 ALA 2207 0.0071

ALA 2207 PRO 2208 0.0422

PRO 2208 GLU 2209 0.0015

GLU 2209 ASP 2210 0.0608

ASP 2210 ALA 2211 0.0338

ALA 2211 MET 2212 0.0563

MET 2212 VAL 2213 0.0505

VAL 2213 PRO 2214 0.0606

PRO 2214 VAL 2215 0.0416

VAL 2215 ILE 2216 0.0579

ILE 2216 THR 2217 0.0172

THR 2217 ARG 2218 0.0606

ARG 2218 PRO 2219 0.0178

PRO 2219 PRO 2220 0.0557

PRO 2220 LYS 2221 0.2707

LYS 2221 LEU 2222 0.0018

LEU 2222 GLN 2223 0.0013

GLN 2223 LEU 2224 0.0016

LEU 2224 ARG 2225 0.0017

ARG 2225 PRO 2226 0.0008

PRO 2226 ASP 2227 0.0028

ASP 2227 ALA 2228 0.0029

ALA 2228 SER 2229 0.0033

SER 2229 TYR 2230 0.0013

TYR 2230 LEU 2231 0.0035

LEU 2231 ILE 2232 0.0028

ILE 2232 VAL 2233 0.0033

VAL 2233 GLY 2234 0.0032

GLY 2234 GLY 2235 0.0032

GLY 2235 LEU 2236 0.0025

LEU 2236 GLY 2237 -0.0164

GLY 2237 GLY 2238 0.0023

GLY 2238 ILE 2239 0.0020

ILE 2239 GLY 2240 0.0021

GLY 2240 ARG 2241 0.0034

ARG 2241 SER 2242 0.0006

SER 2242 LEU 2243 0.0040

LEU 2243 CYS 2244 0.0009

CYS 2244 LYS 2245 0.0036

LYS 2245 ASN 2246 0.0007

ASN 2246 PHE 2247 0.0035

PHE 2247 VAL 2248 0.0020

VAL 2248 GLU 2249 0.0021

GLU 2249 ASN 2250 0.0025

ASN 2250 GLY 2251 0.0022

GLY 2251 ALA 2252 0.0026

ALA 2252 ARG 2253 0.0227

ARG 2253 SER 2254 0.0043

SER 2254 LEU 2255 0.0045

LEU 2255 VAL 2256 0.0045

VAL 2256 LEU 2257 0.0046

LEU 2257 LEU 2258 0.0046

LEU 2258 SER 2259 0.0045

SER 2259 ARG 2260 0.0040

ARG 2260 ASN 2261 0.0023

ASN 2261 ALA 2262 0.0042

ALA 2262 ASN 2263 0.0008

ASN 2263 VAL 2264 0.0041

VAL 2264 SER 2265 0.0043

SER 2265 GLN 2266 0.0041

GLN 2266 GLN 2267 0.0009

GLN 2267 SER 2268 0.0036

SER 2268 GLY 2269 0.0382

GLY 2269 GLU 2270 0.0067

GLU 2270 PHE 2271 0.0012

PHE 2271 LEU 2272 0.0067

LEU 2272 ASP 2273 0.0046

ASP 2273 GLU 2274 0.0031

GLU 2274 LEU 2275 0.0053

LEU 2275 ARG 2276 0.0031

ARG 2276 SER 2277 0.0072

SER 2277 THR 2278 0.0014

THR 2278 GLY 2279 0.0065

GLY 2279 CYS 2280 0.0052

CYS 2280 ILE 2281 0.0062

ILE 2281 VAL 2282 0.0074

VAL 2282 GLY 2283 0.0071

GLY 2283 VAL 2284 0.0071

VAL 2284 VAL 2285 -0.0374

VAL 2285 ASP 2286 0.0036

ASP 2286 CYS 2287 0.0016

CYS 2287 ASP 2288 0.0016

ASP 2288 ILE 2289 0.0018

ILE 2289 SER 2290 0.0032

SER 2290 SER 2291 0.0016

SER 2291 LYS 2292 0.0036

LYS 2292 THR 2293 0.0001

THR 2293 GLN 2294 0.0035

GLN 2294 VAL 2295 0.0023

VAL 2295 GLU 2296 0.0033

GLU 2296 ALA 2297 0.0003

ALA 2297 THR 2298 0.0034

THR 2298 MET 2299 0.0028

MET 2299 LEU 2300 0.0016

LEU 2300 ARG 2301 -0.0224

ARG 2301 LEU 2302 0.0016

LEU 2302 LYS 2303 0.0027

LYS 2303 LYS 2304 0.0003

LYS 2304 ASP 2305 0.0028

ASP 2305 MET 2306 0.0007

MET 2306 LEU 2307 0.0016

LEU 2307 PRO 2308 0.0010

PRO 2308 ILE 2309 0.0017

ILE 2309 ARG 2310 0.0006

ARG 2310 GLY 2311 0.0023

GLY 2311 ILE 2312 0.0029

ILE 2312 VAL 2313 0.0026

VAL 2313 HIS 2314 0.0029

HIS 2314 ALA 2315 0.0028

ALA 2315 GLY 2316 0.0022

GLY 2316 MET 2317 0.1032

MET 2317 VAL 2318 0.0040

VAL 2318 LEU 2319 0.0037

LEU 2319 GLN 2320 0.0032

GLN 2320 ASP 2321 0.0036

ASP 2321 SER 2322 0.0017

SER 2322 VAL 2323 0.0012

VAL 2323 PHE 2324 0.0021

PHE 2324 GLU 2325 0.0033

GLU 2325 ARG 2326 0.0012

ARG 2326 MET 2327 0.0038

MET 2327 SER 2328 0.0039

SER 2328 LEU 2329 0.0039

LEU 2329 ASP 2330 0.0004

ASP 2330 ASP 2331 0.0037

ASP 2331 TYR 2332 0.0023

TYR 2332 ASN 2333 0.0415

ASN 2333 THR 2334 0.0004

THR 2334 ALA 2335 0.0023

ALA 2335 ILE 2336 0.0016

ILE 2336 ARG 2337 0.0016

ARG 2337 PRO 2338 0.0016

PRO 2338 LYS 2339 0.0012

LYS 2339 VAL 2340 0.0014

VAL 2340 GLN 2341 0.0020

GLN 2341 GLY 2342 0.0007

GLY 2342 SER 2343 0.0019

SER 2343 TRP 2344 0.0017

TRP 2344 ASN 2345 0.0008

ASN 2345 LEU 2346 0.0017

LEU 2346 HIS 2347 0.0008

HIS 2347 SER 2348 0.0024

SER 2348 GLY 2349 -0.0322

GLY 2349 LEU 2350 0.0025

LEU 2350 SER 2351 0.0017

SER 2351 ASP 2352 0.0010

ASP 2352 CYS 2353 0.0026

CYS 2353 ASP 2354 0.0022

ASP 2354 LEU 2355 0.0022

LEU 2355 ASP 2356 0.0025

ASP 2356 PHE 2357 0.0021

PHE 2357 PHE 2358 0.0023

PHE 2358 ILE 2359 0.0023

ILE 2359 MET 2360 0.0025

MET 2360 LEU 2361 0.0025

LEU 2361 SER 2362 0.0008

SER 2362 SER 2363 0.0019

SER 2363 LEU 2364 0.0007

LEU 2364 ALA 2365 -0.0165

ALA 2365 GLY 2366 0.0018

GLY 2366 VAL 2367 0.0029

VAL 2367 SER 2368 0.0031

SER 2368 GLY 2369 0.0028

GLY 2369 SER 2370 0.0020

SER 2370 ALA 2371 0.0027

ALA 2371 SER 2372 0.0030

SER 2372 GLN 2373 0.0029

GLN 2373 ALA 2374 0.0006

ALA 2374 ASN 2375 0.0025

ASN 2375 TYR 2376 0.0012

TYR 2376 THR 2377 0.0021

THR 2377 ALA 2378 0.0019

ALA 2378 GLY 2379 0.0012

GLY 2379 GLY 2380 0.0026

GLY 2380 ALA 2381 -0.0099

ALA 2381 TYR 2382 0.0020

TYR 2382 GLN 2383 0.0008

GLN 2383 ASP 2384 0.0013

ASP 2384 ALA 2385 0.0012

ALA 2385 LEU 2386 0.0008

LEU 2386 ALA 2387 0.0017

ALA 2387 LYS 2388 0.0003

LYS 2388 TYR 2389 0.0022

TYR 2389 ARG 2390 0.0004

ARG 2390 ARG 2391 0.0020

ARG 2391 ALA 2392 0.0005

ALA 2392 GLN 2393 0.0014

GLN 2393 GLY 2394 0.0016

GLY 2394 LEU 2395 0.0009

LEU 2395 SER 2396 0.0012

SER 2396 ALA 2397 0.0128

ALA 2397 VAL 2398 0.0018

VAL 2398 SER 2399 0.0018

SER 2399 ILE 2400 0.0012

ILE 2400 ASP 2401 0.0022

ASP 2401 LEU 2402 0.0002

LEU 2402 GLY 2403 0.0020

GLY 2403 MET 2404 0.0003

MET 2404 VAL 2405 0.0010

VAL 2405 GLN 2406 0.0009

GLN 2406 SER 2407 0.0007

SER 2407 VAL 2408 0.0020

VAL 2408 GLY 2409 0.0017

GLY 2409 TYR 2410 0.0022

TYR 2410 VAL 2411 0.0020

VAL 2411 ALA 2412 0.0007

ALA 2412 GLU 2413 -0.0265

GLU 2413 THR 2414 0.0013

THR 2414 LYS 2415 0.0014

LYS 2415 GLY 2416 0.0011

GLY 2416 VAL 2417 0.0007

VAL 2417 ALA 2418 0.0017

ALA 2418 GLU 2419 0.0017

GLU 2419 ARG 2420 0.0005

ARG 2420 LEU 2421 0.0015

LEU 2421 VAL 2422 0.0017

VAL 2422 ARG 2423 0.0014

ARG 2423 MET 2424 0.0007

MET 2424 GLY 2425 0.0015

GLY 2425 TYR 2426 0.0015

TYR 2426 SER 2427 0.0013

SER 2427 PRO 2428 0.0005

PRO 2428 ILE 2429 0.0321

ILE 2429 SER 2430 0.0007

SER 2430 GLU 2431 0.0008

GLU 2431 MET 2432 0.0004

MET 2432 GLU 2433 0.0004

GLU 2433 VAL 2434 0.0005

VAL 2434 LEU 2435 0.0007

LEU 2435 LYS 2436 0.0003

LYS 2436 ILE 2437 0.0008

ILE 2437 VAL 2438 0.0006

VAL 2438 GLU 2439 0.0006

GLU 2439 HIS 2440 0.0002

HIS 2440 ALA 2441 0.0010

ALA 2441 ILE 2442 0.0009

ILE 2442 THR 2443 0.0002

THR 2443 ASN 2444 0.0004

ASN 2444 PRO 2445 0.0382

PRO 2445 PRO 2446 0.0002

PRO 2446 PRO 2447 0.0014

PRO 2447 GLU 2448 0.0003

GLU 2448 ALA 2449 0.0015

ALA 2449 SER 2450 0.0010

SER 2450 SER 2451 0.0008

SER 2451 ALA 2452 0.0013

ALA 2452 GLN 2453 0.0013

GLN 2453 ILE 2454 0.0015

ILE 2454 ILE 2455 0.0010

ILE 2455 THR 2456 0.0013

THR 2456 GLY 2457 0.0015

GLY 2457 ILE 2458 0.0003

ILE 2458 SER 2459 0.0013

SER 2459 THR 2460 0.0016

THR 2460 LYS 2461 -0.0109

LYS 2461 PRO 2462 0.0035

PRO 2462 GLY 2463 0.0036

GLY 2463 ARG 2464 0.0023

ARG 2464 HIS 2465 0.0031

HIS 2465 TRP 2466 0.0029

TRP 2466 THR 2467 0.0031

THR 2467 GLU 2468 0.0035

GLU 2468 SER 2469 0.0037

SER 2469 SER 2470 0.0000

SER 2470 TRP 2471 0.0038

TRP 2471 LEU 2472 0.0024

LEU 2472 GLN 2473 0.0015

GLN 2473 ASP 2474 0.0023

ASP 2474 ALA 2475 0.0037

ALA 2475 ARG 2476 0.0029

ARG 2476 PHE 2477 -0.0118

PHE 2477 ALA 2478 0.0091

ALA 2478 THR 2479 0.0058

THR 2479 LEU 2480 0.0045

LEU 2480 ARG 2481 0.0090

ARG 2481 GLU 2482 0.0086

GLU 2482 ARG 2483 0.0036

ARG 2483 ALA 2484 0.0081

ALA 2484 ARG 2485 0.0089

ARG 2485 ASP 2486 0.0068

ASP 2486 VAL 2487 0.0037

VAL 2487 LYS 2488 0.0091

LYS 2488 GLU 2489 0.0090

GLU 2489 LEU 2490 0.0048

LEU 2490 SER 2491 0.0061

SER 2491 ASN 2492 0.0088

ASN 2492 SER 2493 0.0604

SER 2493 GLN 2494 0.0028

GLN 2494 ASN 989 0.1512

ASN 989 LYS 990 0.0387

LYS 990 ALA 991 0.0277

ALA 991 HIS 992 0.0221

HIS 992 ARG 993 0.0383

ARG 993 GLN 994 0.0388

GLN 994 ARG 995 0.0213

ARG 995 VAL 996 0.0271

VAL 996 HIS 997 0.0153

HIS 997 PRO 998 0.0264

PRO 998 PRO 999 0.0371

PRO 999 HIS 1000 0.0273

HIS 1000 ASP 1001 0.0125

ASP 1001 LEU 1002 0.0367

LEU 1002 LEU 1003 0.0003

LEU 1003 GLY 1004 0.0358

GLY 1004 SER 1005 0.0277

SER 1005 LEU 1006 0.0120

LEU 1006 ILE 1007 0.0192

ILE 1007 VAL 1008 0.0177

VAL 1008 GLY 1009 0.0047

GLY 1009 ARG 1010 0.0358

ARG 1010 ASP 1011 0.0335

ASP 1011 LEU 1012 0.0211

LEU 1012 ARG 1013 0.0359

ARG 1013 GLU 1014 0.0313

GLU 1014 PRO 1015 0.0227

PRO 1015 THR 1016 0.0269

THR 1016 TRP 1017 0.0130

TRP 1017 ARG 1018 0.0346

ARG 1018 HIS 1019 0.0024

HIS 1019 PHE 1020 0.0306

PHE 1020 ILE 1021 -0.0064

ILE 1021 ARG 1022 0.0256

ARG 1022 VAL 1023 0.0004

VAL 1023 GLN 1024 0.0361

GLN 1024 ASP 1025 0.0281

ASP 1025 ILE 1026 0.0287

ILE 1026 PRO 1027 0.0069

PRO 1027 TRP 1028 0.0310

TRP 1028 ILE 1029 0.0244

ILE 1029 ARG 1030 0.0207

ARG 1030 ASP 1031 0.0213

ASP 1031 HIS 1032 0.0243

HIS 1032 VAL 1033 0.0362

VAL 1033 VAL 1034 0.0344

VAL 1034 GLN 1035 0.0357

GLN 1035 SER 1036 0.0354

SER 1036 ALA 1037 -0.0242

ALA 1037 LEU 1038 0.0350

LEU 1038 VAL 1039 0.0283

VAL 1039 TYR 1040 0.0295

TYR 1040 PRO 1041 0.0295

PRO 1041 GLY 1042 0.0261

GLY 1042 ALA 1043 0.0340

ALA 1043 GLY 1044 0.0274

GLY 1044 PHE 1045 0.0090

PHE 1045 ILE 1046 0.0355

ILE 1046 CYS 1047 0.0341

CYS 1047 MET 1048 0.0110

MET 1048 ALA 1049 0.0262

ALA 1049 MET 1050 0.0293

MET 1050 GLU 1051 0.0355

GLU 1051 ALA 1052 0.0037

ALA 1052 MET 1053 0.0188

MET 1053 VAL 1054 0.0331

VAL 1054 GLN 1055 0.0248

GLN 1055 LEU 1056 0.0158

LEU 1056 HIS 1057 0.0378

HIS 1057 GLU 1058 0.0389

GLU 1058 LEU 1059 0.0096

LEU 1059 ARG 1060 0.0297

ARG 1060 ASP 1061 0.0343

ASP 1061 SER 1062 0.0385

SER 1062 GLN 1063 0.0359

GLN 1063 SER 1064 0.0001

SER 1064 ARG 1065 0.0380

ARG 1065 LYS 1066 0.0005

LYS 1066 VAL 1067 0.0358

VAL 1067 ALA 1068 0.0246

ALA 1068 GLY 1069 0.0386

GLY 1069 TYR 1070 0.0319

TYR 1070 ARG 1071 0.0360

ARG 1071 LEU 1072 0.0364

LEU 1072 ALA 1073 0.0346

ALA 1073 GLU 1074 0.0361

GLU 1074 VAL 1075 0.0300

VAL 1075 ASP 1076 0.0369

ASP 1076 ILE 1077 0.0288

ILE 1077 LEU 1078 0.0262

LEU 1078 ARG 1079 0.0313

ARG 1079 ALA 1080 0.0178

ALA 1080 MET 1081 0.0331

MET 1081 LEU 1082 0.0300

LEU 1082 ILE 1083 0.0360

ILE 1083 PRO 1084 0.0368

PRO 1084 ASP 1085 0.0292

ASP 1085 THR 1086 0.0210

THR 1086 SER 1087 0.0322

SER 1087 GLU 1088 0.0091

GLU 1088 GLY 1089 0.0332

GLY 1089 LEU 1090 0.0264

LEU 1090 GLU 1091 0.0088

GLU 1091 ALA 1092 0.0378

ALA 1092 HIS 1093 0.0175

HIS 1093 ILE 1094 0.0377

ILE 1094 SER 1095 0.0085

SER 1095 LEU 1096 0.0367

LEU 1096 ARG 1097 0.0138

ARG 1097 PRO 1098 0.0352

PRO 1098 CYS 1099 0.0373

CYS 1099 SER 1100 0.0073

SER 1100 THR 1101 0.0506

THR 1101 LYS 1102 0.0396

LYS 1102 LEU 1103 0.0005

LEU 1103 LEU 1104 0.0389

LEU 1104 LEU 1105 0.0232

LEU 1105 THR 1106 0.0402

THR 1106 ASN 1107 0.0358

ASN 1107 GLU 1108 0.0358

GLU 1108 TRP 1109 0.0304

TRP 1109 TYR 1110 0.0403

TYR 1110 ASP 1111 0.0398

ASP 1111 PHE 1112 0.0265

PHE 1112 CYS 1113 0.0401

CYS 1113 VAL 1114 0.0226

VAL 1114 SER 1115 0.0380

SER 1115 SER 1116 0.0381

SER 1116 VAL 1117 0.0235

VAL 1117 GLY 1118 0.0348

GLY 1118 ASP 1119 0.0368

ASP 1119 ASP 1120 0.0128

ASP 1120 ASP 1121 0.0334

ASP 1121 LYS 1122 0.0379

LYS 1122 PHE 1123 0.0347

PHE 1123 VAL 1124 0.0143

VAL 1124 ASP 1125 0.0376

ASP 1125 HIS 1126 0.0029

HIS 1126 CYS 1127 0.0387

CYS 1127 ARG 1128 0.0222

ARG 1128 GLY 1129 0.0384

GLY 1129 ARG 1130 0.0341

ARG 1130 ILE 1131 0.0359

ILE 1131 THR 1132 0.0367

THR 1132 ILE 1133 0.0243

ILE 1133 GLU 1134 0.0400

GLU 1134 PHE 1135 0.0467

PHE 1135 ASP 1136 0.0346

ASP 1136 THR 1137 0.0384

THR 1137 SER 1138 0.0466

SER 1138 GLY 1139 0.0465

GLY 1139 SER 1140 0.0367

SER 1140 ALA 1141 0.0053

ALA 1141 ASP 1142 0.0293

ASP 1142 THR 1143 0.0479

THR 1143 PRO 1144 0.0007

PRO 1144 ARG 1145 0.0476

ARG 1145 THR 1146 0.0176

THR 1146 SER 1147 0.0159

SER 1147 LEU 1148 0.0399

LEU 1148 ARG 1149 0.0614

ARG 1149 GLU 1150 0.0295

GLU 1150 ARG 1151 0.0297

ARG 1151 SER 1152 0.0097

SER 1152 ARG 1153 0.0230

ARG 1153 SER 1154 0.0325

SER 1154 THR 1155 0.0074

THR 1155 GLY 1156 0.0319

GLY 1156 LEU 1157 0.0233

LEU 1157 MET 1158 0.0259

MET 1158 ARG 1159 0.0314

ARG 1159 SER 1160 0.0325

SER 1160 VAL 1161 0.0237

VAL 1161 ASP 1162 0.0323

ASP 1162 PRO 1163 0.0036

PRO 1163 SER 1164 0.0317

SER 1164 ASN 1165 -0.0312

ASN 1165 LEU 1166 0.0049

LEU 1166 TYR 1167 0.0305

TYR 1167 SER 1168 0.0257

SER 1168 PHE 1169 0.0318

PHE 1169 LEU 1170 0.0033

LEU 1170 ARG 1171 0.0354

ARG 1171 ALA 1172 0.0315

ALA 1172 GLN 1173 0.0131

GLN 1173 GLY 1174 0.0240

GLY 1174 ILE 1175 0.0350

ILE 1175 TYR 1176 0.0310

TYR 1176 HIS 1177 0.0356

HIS 1177 GLY 1178 0.0325

GLY 1178 PRO 1179 0.0256

PRO 1179 ILE 1180 0.0159

ILE 1180 PHE 1181 0.0464

PHE 1181 GLN 1182 0.0022

GLN 1182 ASN 1183 0.0330

ASN 1183 LEU 1184 0.0248

LEU 1184 LYS 1185 0.0072

LYS 1185 THR 1186 0.0292

THR 1186 ILE 1187 0.0313

ILE 1187 SER 1188 0.0296

SER 1188 SER 1189 0.0286

SER 1189 ARG 1190 0.0332

ARG 1190 LYS 1191 0.0253

LYS 1191 ASP 1192 0.0089

ASP 1192 HIS 1193 0.0330

HIS 1193 SER 1194 0.0298

SER 1194 GLU 1195 0.0323

GLU 1195 SER 1196 0.0328

SER 1196 SER 1197 0.0648

SER 1197 PHE 1198 0.0281

PHE 1198 VAL 1199 0.0334

VAL 1199 VAL 1200 0.0100

VAL 1200 ALA 1201 0.0341

ALA 1201 ASN 1202 0.0341

ASN 1202 THR 1203 0.0135

THR 1203 ALA 1204 0.0316

ALA 1204 SER 1205 0.0101

SER 1205 VAL 1206 0.0306

VAL 1206 MET 1207 0.0046

MET 1207 PRO 1208 0.0321

PRO 1208 ASN 1209 0.0323

ASN 1209 GLY 1210 0.0306

GLY 1210 PHE 1211 0.0033

PHE 1211 GLN 1212 0.0307

GLN 1212 SER 1213 0.0090

SER 1213 PRO 1214 0.0347

PRO 1214 HIS 1215 0.0353

HIS 1215 VAL 1216 0.0353

VAL 1216 ILE 1217 0.0194

ILE 1217 HIS 1218 0.0311

HIS 1218 PRO 1219 0.0351

PRO 1219 THR 1220 0.0008

THR 1220 THR 1221 0.0343

THR 1221 LEU 1222 0.0210

LEU 1222 ASP 1223 0.0314

ASP 1223 SER 1224 0.0048

SER 1224 ILE 1225 0.0315

ILE 1225 PHE 1226 0.0304

PHE 1226 GLN 1227 0.0079

GLN 1227 GLY 1228 0.0299

GLY 1228 ALA 1229 0.0433

ALA 1229 TYR 1230 0.0206

TYR 1230 THR 1231 0.0126

THR 1231 ALA 1232 0.0304

ALA 1232 LEU 1233 0.0322

LEU 1233 PRO 1234 0.0114

PRO 1234 GLY 1235 0.0166

GLY 1235 ALA 1236 0.0226

ALA 1236 GLY 1237 0.0213

GLY 1237 LEU 1238 0.0160

LEU 1238 ASP 1239 0.0317

ASP 1239 GLN 1240 0.0024

GLN 1240 ASN 1241 0.0295

ASN 1241 THR 1242 0.0111

THR 1242 ALA 1243 0.0274

ALA 1243 MET 1244 0.0228

MET 1244 ILE 1245 -0.0065

ILE 1245 PRO 1246 0.0246

PRO 1246 ARG 1247 0.0114

ARG 1247 SER 1248 0.0298

SER 1248 ILE 1249 0.0352

ILE 1249 GLN 1250 0.0290

GLN 1250 GLU 1251 0.0352

GLU 1251 LEU 1252 0.0292

LEU 1252 TYR 1253 0.0353

TYR 1253 LEU 1254 0.0318

LEU 1254 SER 1255 0.0347

SER 1255 SER 1256 0.0332

SER 1256 ALA 1257 0.0069

ALA 1257 LEU 1258 0.0298

LEU 1258 THR 1259 0.0315

THR 1259 SER 1260 0.0355

SER 1260 ASP 1261 0.0152

ASP 1261 VAL 1262 0.0213

VAL 1262 GLY 1263 0.0093

GLY 1263 GLN 1264 0.0309

GLN 1264 CYS 1265 0.0274

CYS 1265 LEU 1266 0.0216

LEU 1266 VAL 1267 0.0302

VAL 1267 SER 1268 0.0248

SER 1268 ASP 1269 0.0335

ASP 1269 THR 1270 0.0297

THR 1270 SER 1271 0.0327

SER 1271 LEU 1272 0.0326

LEU 1272 ILE 1273 0.0124

ILE 1273 ARG 1274 0.0337

ARG 1274 TYR 1275 0.0269

TYR 1275 ASP 1276 0.0327

ASP 1276 GLY 1277 0.0200

GLY 1277 GLN 1278 0.0088

GLN 1278 SER 1279 0.0301

SER 1279 PHE 1280 0.0300

PHE 1280 THR 1281 0.0276

THR 1281 VAL 1282 0.0276

VAL 1282 ASN 1283 0.0323

ASN 1283 VAL 1284 0.0296

VAL 1284 ASP 1285 0.0330

ASP 1285 VAL 1286 0.0311

VAL 1286 SER 1287 0.0291

SER 1287 SER 1288 0.0285

SER 1288 LYS 1289 0.0000

LYS 1289 ALA 1290 0.0336

ALA 1290 ASP 1291 0.0232

ASP 1291 SER 1292 0.0230

SER 1292 GLU 1293 0.0045

GLU 1293 HIS 1294 0.0338

HIS 1294 THR 1295 0.0007

THR 1295 PRO 1296 0.0276

PRO 1296 VAL 1297 0.0276

VAL 1297 LEU 1298 0.0312

LEU 1298 GLU 1299 0.0331

GLU 1299 ILE 1300 0.0327

ILE 1300 LYS 1301 0.0316

LYS 1301 GLY 1302 0.0342

GLY 1302 LEU 1303 0.0310

LEU 1303 ARG 1304 0.0339

ARG 1304 ASN 1305 0.0259

ASN 1305 GLN 1306 0.0327

GLN 1306 SER 1307 0.0280

SER 1307 VAL 1308 0.0298

VAL 1308 GLY 1309 0.0757

GLY 1309 GLN 1310 0.0052

GLN 1310 MET 1311 0.0019

MET 1311 ALA 1312 0.0034

ALA 1312 PRO 1313 0.0074

PRO 1313 GLN 1314 0.0022

GLN 1314 PRO 1315 0.0029

PRO 1315 GLY 1316 0.0074

GLY 1316 ASP 1317 0.0002

ASP 1317 SER 1318 0.0072

SER 1318 SER 1319 0.0036

SER 1319 ASN 1320 0.0058

ASN 1320 ASN 1321 0.0071

ASN 1321 ASP 1322 0.0058

ASP 1322 LEU 1323 0.0029

LEU 1323 CYS 1324 0.0073

CYS 1324 PHE 1325 -0.0165

PHE 1325 LYS 1326 0.0060

LYS 1326 LEU 1327 0.0005

LEU 1327 ASP 1328 0.0127

ASP 1328 TRP 1329 0.0013

TRP 1329 ALA 1330 0.0124

ALA 1330 PRO 1331 0.0034

PRO 1331 ASP 1332 0.0109

ASP 1332 ILE 1333 0.0132

ILE 1333 SER 1334 0.0045

SER 1334 SER 1335 0.0094

SER 1335 VAL 1336 0.0109

VAL 1336 LYS 1337 0.0083

LYS 1337 GLN 1338 0.0124

GLN 1338 GLU 1339 0.0127

GLU 1339 ARG 1340 0.0072

ARG 1340 LEU 1341 0.0722

LEU 1341 LYS 1342 0.0247

LYS 1342 GLU 1343 0.0270

GLU 1343 LYS 1344 0.0050

LYS 1344 PHE 1345 0.0203

PHE 1345 GLY 1346 0.0205

GLY 1346 PHE 1347 0.0220

PHE 1347 PRO 1348 0.0212

PRO 1348 LEU 1349 0.0266

LEU 1349 ASP 1350 0.0109

ASP 1350 PRO 1351 0.0253

PRO 1351 THR 1352 0.0028

THR 1352 GLU 1353 0.0272

GLU 1353 ALA 1354 0.0065

ALA 1354 ASP 1355 0.0223

ASP 1355 ILE 1356 0.0106

ILE 1356 ILE 1357 -0.0159

ILE 1357 MET 1358 0.0233

MET 1358 GLY 1359 0.0050

GLY 1359 LEU 1360 0.0271

LEU 1360 ARG 1361 0.0076

ARG 1361 GLN 1362 0.0261

GLN 1362 ALA 1363 0.0041

ALA 1363 CYS 1364 0.0239

CYS 1364 ILE 1365 0.0171

ILE 1365 HIS 1366 0.0114

HIS 1366 PHE 1367 0.0200

PHE 1367 ILE 1368 0.0105

ILE 1368 HIS 1369 0.0261

HIS 1369 ARG 1370 0.0030

ARG 1370 SER 1371 0.0275

SER 1371 LEU 1372 0.0069

LEU 1372 GLN 1373 0.0320

GLN 1373 SER 1374 0.0053

SER 1374 LEU 1375 0.0249

LEU 1375 THR 1376 0.0278

THR 1376 ALA 1377 0.0177

ALA 1377 PRO 1378 0.0122

PRO 1378 ASP 1379 0.0261

ASP 1379 ARG 1380 0.0034

ARG 1380 ASP 1381 0.0279

ASP 1381 GLN 1382 0.0091

GLN 1382 LEU 1383 0.0239

LEU 1383 ASP 1384 0.0278

ASP 1384 TRP 1385 0.0054

TRP 1385 HIS 1386 0.0273

HIS 1386 GLN 1387 0.0244

GLN 1387 LYS 1388 0.0085

LYS 1388 ARG 1389 0.0194

ARG 1389 PHE 1390 0.0185

PHE 1390 TYR 1391 0.0272

TYR 1391 ASP 1392 0.0005

ASP 1392 TRP 1393 0.0277

TRP 1393 MET 1394 0.0194

MET 1394 VAL 1395 0.0146

VAL 1395 LEU 1396 0.0138

LEU 1396 GLN 1397 0.0205

GLN 1397 ILE 1398 0.0278

ILE 1398 GLN 1399 0.0010

GLN 1399 LEU 1400 0.0271

LEU 1400 ALA 1401 0.0176

ALA 1401 GLU 1402 0.0212

GLU 1402 GLU 1403 0.0071

GLU 1403 ASP 1404 0.0248

ASP 1404 ARG 1405 0.0314

ARG 1405 LEU 1406 0.0041

LEU 1406 ALA 1407 0.0280

ALA 1407 PRO 1408 0.0220

PRO 1408 ASN 1409 0.0242

ASN 1409 SER 1410 0.0195

SER 1410 SER 1411 0.0273

SER 1411 ALA 1412 0.0178

ALA 1412 TRP 1413 0.0131

TRP 1413 LEU 1414 0.0280

LEU 1414 GLN 1415 0.0271

GLN 1415 CYS 1416 0.0104

CYS 1416 SER 1417 0.0108

SER 1417 SER 1418 0.0073

SER 1418 SER 1419 0.0240

SER 1419 ASP 1420 0.0123

ASP 1420 GLU 1421 0.0276

GLU 1421 GLN 1422 0.0017

GLN 1422 LYS 1423 0.0275

LYS 1423 LEU 1424 0.0128

LEU 1424 LEU 1425 0.0186

LEU 1425 GLU 1426 0.0131

GLU 1426 ASN 1427 0.0170

ASN 1427 VAL 1428 0.0233

VAL 1428 ARG 1429 0.0056

ARG 1429 ALA 1430 0.0263

ALA 1430 SER 1431 0.0077

SER 1431 SER 1432 0.0282

SER 1432 VAL 1433 0.0241

VAL 1433 ASN 1434 0.0088

ASN 1434 GLY 1435 0.0265

GLY 1435 GLN 1436 0.0038

GLN 1436 MET 1437 0.0212

MET 1437 VAL 1438 0.0150

VAL 1438 VAL 1439 0.0156

VAL 1439 HIS 1440 0.0150

HIS 1440 VAL 1441 0.0173

VAL 1441 GLY 1442 0.0199

GLY 1442 LYS 1443 0.0107

LYS 1443 SER 1444 0.0266

SER 1444 MET 1445 0.0034

MET 1445 LEU 1446 0.0278

LEU 1446 ALA 1447 0.0072

ALA 1447 ILE 1448 0.0229

ILE 1448 LEU 1449 0.0120

LEU 1449 ARG 1450 0.0155

ARG 1450 HIS 1451 0.0222

HIS 1451 GLU 1452 0.0092

GLU 1452 ILE 1453 0.0294

ILE 1453 ALA 1454 0.0255

ALA 1454 PRO 1455 0.0173

PRO 1455 LEU 1456 0.0271

LEU 1456 GLU 1457 0.0011

GLU 1457 LEU 1458 0.0276

LEU 1458 MET 1459 0.0208

MET 1459 LEU 1460 0.0135

LEU 1460 GLN 1461 0.0162

GLN 1461 ASP 1462 0.0259

ASP 1462 LYS 1463 0.0193

LYS 1463 LEU 1464 0.0122

LEU 1464 LEU 1465 0.0172

LEU 1465 TYR 1466 0.0264

TYR 1466 ARG 1467 0.0281

ARG 1467 TYR 1468 0.0062

TYR 1468 TYR 1469 0.0320

TYR 1469 THR 1470 0.0227

THR 1470 ASP 1471 0.0254

ASP 1471 ALA 1472 0.0118

ALA 1472 ILE 1473 0.0088

ILE 1473 LYS 1474 0.0125

LYS 1474 TRP 1475 0.0173

TRP 1475 ASP 1476 0.0231

ASP 1476 ARG 1477 0.0027

ARG 1477 SER 1478 0.0237

SER 1478 TYR 1479 0.0091

TYR 1479 GLN 1480 0.0243

GLN 1480 GLN 1481 0.0039

GLN 1481 ILE 1482 0.0209

ILE 1482 ASP 1483 0.0154

ASP 1483 GLN 1484 0.0105

GLN 1484 LEU 1485 0.0274

LEU 1485 VAL 1486 0.0082

VAL 1486 LYS 1487 0.0198

LYS 1487 LEU 1488 0.0027

LEU 1488 HIS 1489 0.0208

HIS 1489 ALA 1490 0.0041

ALA 1490 HIS 1491 0.0186

HIS 1491 LYS 1492 0.0084

LYS 1492 CYS 1493 0.0153

CYS 1493 PRO 1494 0.0012

PRO 1494 THR 1495 0.0202

THR 1495 ALA 1496 0.0172

ALA 1496 LYS 1497 0.0184

LYS 1497 ILE 1498 0.0207

ILE 1498 ILE 1499 0.0204

ILE 1499 GLU 1500 0.0200

GLU 1500 ILE 1501 0.0209

ILE 1501 GLY 1502 0.0155

GLY 1502 ALA 1503 0.0157

ALA 1503 GLY 1504 0.0147

GLY 1504 THR 1505 0.0138

THR 1505 GLY 1506 0.0200

GLY 1506 GLY 1507 0.0181

GLY 1507 CYS 1508 0.0092

CYS 1508 THR 1509 0.0156

THR 1509 ARG 1510 0.0174

ARG 1510 ALA 1511 0.0071

ALA 1511 VAL 1512 0.0201

VAL 1512 LEU 1513 0.0064

LEU 1513 ASP 1514 0.0228

ASP 1514 ALA 1515 0.0026

ALA 1515 LEU 1516 0.0217

LEU 1516 SER 1517 0.0045

SER 1517 ASN 1518 0.0214

ASN 1518 GLN 1519 0.0038

GLN 1519 GLY 1520 0.0173

GLY 1520 ILE 1521 0.0148

ILE 1521 ALA 1522 0.0139

ALA 1522 ARG 1523 0.0017

ARG 1523 CYS 1524 0.0208

CYS 1524 ALA 1525 0.0202

ALA 1525 GLN 1526 0.0199

GLN 1526 TYR 1527 0.0214

TYR 1527 ASP 1528 0.0211

ASP 1528 PHE 1529 0.0182

PHE 1529 THR 1530 0.0193

THR 1530 ASP 1531 0.0210

ASP 1531 VAL 1532 0.0210

VAL 1532 SER 1533 -0.0113

SER 1533 SER 1534 0.0092

SER 1534 GLY 1535 0.0197

GLY 1535 PHE 1536 0.0233

PHE 1536 PHE 1537 0.0232

PHE 1537 GLU 1538 0.0013

GLU 1538 ALA 1539 0.0232

ALA 1539 ALA 1540 0.0109

ALA 1540 GLN 1541 0.0169

GLN 1541 GLN 1542 0.0127

GLN 1542 LYS 1543 0.0123

LYS 1543 PHE 1544 0.0193

PHE 1544 ALA 1545 0.0100

ALA 1545 ALA 1546 0.0221

ALA 1546 PHE 1547 0.0092

PHE 1547 ASP 1548 0.0191

ASP 1548 ASP 1549 -0.0030

ASP 1549 VAL 1550 0.0028

VAL 1550 ILE 1551 0.0243

ILE 1551 ARG 1552 0.0246

ARG 1552 PHE 1553 0.0240

PHE 1553 GLN 1554 0.0194

GLN 1554 LYS 1555 0.0222

LYS 1555 LEU 1556 0.0008

LEU 1556 ASP 1557 0.0179

ASP 1557 ILE 1558 0.0033

ILE 1558 GLU 1559 0.0204

GLU 1559 LYS 1560 0.0212

LYS 1560 ASP 1561 0.0223

ASP 1561 ILE 1562 0.0216

ILE 1562 GLU 1563 0.0238

GLU 1563 MET 1564 0.0171

MET 1564 GLN 1565 0.0120

GLN 1565 GLY 1566 0.0232

GLY 1566 PHE 1567 0.0144

PHE 1567 GLU 1568 0.0152

GLU 1568 CYS 1569 0.0013

CYS 1569 GLY 1570 0.0184

GLY 1570 SER 1571 0.0072

SER 1571 TYR 1572 0.0241

TYR 1572 ASP 1573 0.0197

ASP 1573 LEU 1574 0.0230

LEU 1574 VAL 1575 0.0236

VAL 1575 ILE 1576 0.0206

ILE 1576 ALA 1577 0.0241

ALA 1577 SER 1578 0.0220

SER 1578 GLN 1579 0.0240

GLN 1579 VAL 1580 0.0240

VAL 1580 LEU 1581 0.0179

LEU 1581 HIS 1582 0.0227

HIS 1582 ALA 1583 0.0122

ALA 1583 THR 1584 0.0185

THR 1584 GLY 1585 0.0173

GLY 1585 LYS 1586 0.0080

LYS 1586 MET 1587 0.0238

MET 1587 GLU 1588 0.0142

GLU 1588 HIS 1589 0.0131

HIS 1589 THR 1590 0.0116

THR 1590 MET 1591 0.0164

MET 1591 ALA 1592 0.0227

ALA 1592 ASN 1593 0.0014

ASN 1593 VAL 1594 0.0242

VAL 1594 ARG 1595 0.0109

ARG 1595 LYS 1596 0.0195

LYS 1596 LEU 1597 0.0103

LEU 1597 LEU 1598 0.0168

LEU 1598 LYS 1599 0.0214

LYS 1599 PRO 1600 0.0009

PRO 1600 GLY 1601 0.0245

GLY 1601 GLY 1602 0.0045

GLY 1602 LYS 1603 0.0239

LYS 1603 LEU 1604 0.0234

LEU 1604 LEU 1605 0.0196

LEU 1605 LEU 1606 0.0244

LEU 1606 VAL 1607 0.0204

VAL 1607 GLU 1608 0.0217

GLU 1608 THR 1609 0.0238

THR 1609 THR 1610 0.0004

THR 1610 ARG 1611 0.0243

ARG 1611 ASP 1612 0.0133

ASP 1612 GLU 1613 -0.0157

GLU 1613 MET 1614 0.0232

MET 1614 ASP 1615 0.0022

ASP 1615 LEU 1616 0.0271

LEU 1616 GLN 1617 0.0213

GLN 1617 LEU 1618 0.0163

LEU 1618 VAL 1619 0.0096

VAL 1619 PHE 1620 0.0249

PHE 1620 GLY 1621 0.0175

GLY 1621 LEU 1622 0.0089

LEU 1622 LEU 1623 0.0266

LEU 1623 PRO 1624 0.0213

PRO 1624 GLY 1625 0.0256

GLY 1625 TRP 1626 0.0172

TRP 1626 TRP 1627 0.0170

TRP 1627 LEU 1628 0.0269

LEU 1628 SER 1629 0.0114

SER 1629 SER 1630 0.0161

SER 1630 GLU 1631 0.0117

GLU 1631 GLU 1632 0.0193

GLU 1632 GLU 1633 0.0277

GLU 1633 ARG 1634 0.0002

ARG 1634 GLN 1635 0.0261

GLN 1635 MET 1636 0.0271

MET 1636 SER 1637 0.0233

SER 1637 PRO 1638 0.0230

PRO 1638 SER 1639 0.0224

SER 1639 LEU 1640 0.0076

LEU 1640 SER 1641 0.0171

SER 1641 THR 1642 0.0272

THR 1642 ASN 1643 0.0036

ASN 1643 SER 1644 0.0240

SER 1644 TRP 1645 0.0179

TRP 1645 GLU 1646 0.0096

GLU 1646 LYS 1647 0.0184

LYS 1647 VAL 1648 0.0076

VAL 1648 LEU 1649 0.0218

LEU 1649 LYS 1650 0.0033

LYS 1650 LYS 1651 0.0229

LYS 1651 THR 1652 0.0047

THR 1652 GLY 1653 0.0223

GLY 1653 PHE 1654 0.0225

PHE 1654 ASP 1655 0.0113

ASP 1655 GLY 1656 0.0226

GLY 1656 LEU 1657 0.0169

LEU 1657 ASP 1658 0.0229

ASP 1658 ILE 1659 0.0168

ILE 1659 GLU 1660 0.0223

GLU 1660 LEU 1661 0.0087

LEU 1661 ARG 1662 0.0252

ARG 1662 ASP 1663 0.0063

ASP 1663 CYS 1664 0.0186

CYS 1664 ASP 1665 0.0037

ASP 1665 SER 1666 0.0248

SER 1666 ASP 1667 0.0166

ASP 1667 GLU 1668 0.0193

GLU 1668 PHE 1669 0.0027

PHE 1669 TYR 1670 0.0259

TYR 1670 SER 1671 0.0208

SER 1671 PHE 1672 0.0240

PHE 1672 SER 1673 0.0183

SER 1673 VAL 1674 0.0222

VAL 1674 MET 1675 0.0145

MET 1675 MET 1676 0.0255

MET 1676 ALA 1677 -0.0463

ALA 1677 THR 1678 0.0118

THR 1678 ALA 1679 0.0116

ALA 1679 SER 1680 0.0024

SER 1680 SER 1681 0.0120

SER 1681 THR 1682 0.0054

THR 1682 ILE 1683 0.0117

ILE 1683 ALA 1684 0.0114

ALA 1684 SER 1685 0.0050

SER 1685 SER 1686 0.0100

SER 1686 SER 1687 0.0069

SER 1687 MET 1688 0.0080

MET 1688 ALA 1689 0.0103

ALA 1689 PHE 1690 0.0110

PHE 1690 ALA 1691 0.0118

ALA 1691 ILE 1692 0.0115

ILE 1692 VAL 1693 0.0119

VAL 1693 TYR 1694 0.0071

TYR 1694 GLY 1695 0.0050

GLY 1695 GLU 1696 0.0061

GLU 1696 VAL 1697 0.0055

VAL 1697 PRO 1698 0.0029

PRO 1698 LEU 1699 0.0072

LEU 1699 PRO 1700 0.0033

PRO 1700 ASP 1701 0.0024

ASP 1701 GLN 1702 0.0071

GLN 1702 PHE 1703 0.0007

PHE 1703 LEU 1704 0.0068

LEU 1704 ASP 1705 0.0025

ASP 1705 ASP 1706 0.0052

ASP 1706 MET 1707 0.0031

MET 1707 LYS 1708 0.0044

LYS 1708 THR 1709 -0.0005

THR 1709 ALA 1710 0.0020

ALA 1710 ILE 1711 0.0068

ILE 1711 SER 1712 0.0018

SER 1712 SER 1713 0.0079

SER 1713 SER 1714 0.0011

SER 1714 ALA 1715 0.0077

ALA 1715 VAL 1716 0.0043

VAL 1716 SER 1717 0.0077

SER 1717 ASP 1718 0.0073

ASP 1718 PRO 1719 0.0034

PRO 1719 VAL 1720 0.0078

VAL 1720 VAL 1721 0.0074

VAL 1721 GLY 1722 0.0069

GLY 1722 HIS 1723 0.0051

HIS 1723 LEU 1724 0.0012

LEU 1724 ASP 1725 -0.0054

ASP 1725 SER 1726 0.0018

SER 1726 ILE 1727 0.0062

ILE 1727 ASP 1728 0.0062

ASP 1728 ALA 1729 0.0032

ALA 1729 THR 1730 0.0060

THR 1730 GLY 1731 0.0062

GLY 1731 LYS 1732 0.0060

LYS 1732 PHE 1733 0.0045

PHE 1733 CYS 1734 0.0061

CYS 1734 ILE 1735 0.0063

ILE 1735 PHE 1736 0.0057

PHE 1736 ILE 1737 0.0059

ILE 1737 GLU 1738 0.0050

GLU 1738 ASP 1739 0.0057

ASP 1739 PRO 1740 0.0033

PRO 1740 GLU 1741 0.0253

GLU 1741 THR 1742 0.0043

THR 1742 ASP 1743 0.0010

ASP 1743 ILE 1744 0.0044

ILE 1744 LEU 1745 0.0007

LEU 1745 SER 1746 0.0035

SER 1746 SER 1747 0.0043

SER 1747 PRO 1748 0.0029

PRO 1748 ASP 1749 0.0037

ASP 1749 GLU 1750 0.0046

GLU 1750 LYS 1751 0.0005

LYS 1751 SER 1752 0.0047

SER 1752 TYR 1753 0.0010

TYR 1753 ALA 1754 0.0042

ALA 1754 SER 1755 0.0017

SER 1755 ILE 1756 0.0032

ILE 1756 GLN 1757 0.0019

GLN 1757 LYS 1758 0.0014

LYS 1758 LEU 1759 0.0050

LEU 1759 VAL 1760 0.0014

VAL 1760 THR 1761 0.0052

THR 1761 ARG 1762 0.0006

ARG 1762 CYS 1763 0.0051

CYS 1763 LYS 1764 0.0051

LYS 1764 GLY 1765 0.0043

GLY 1765 LEU 1766 0.0052

LEU 1766 ILE 1767 0.0052

ILE 1767 TRP 1768 0.0045

TRP 1768 VAL 1769 0.0048

VAL 1769 SER 1770 0.0039

SER 1770 ARG 1771 0.0051

ARG 1771 GLY 1772 0.0012

GLY 1772 GLY 1773 0.0010

GLY 1773 ALA 1774 0.0029

ALA 1774 MET 1775 0.0028

MET 1775 HIS 1776 0.0035

HIS 1776 GLY 1777 0.0035

GLY 1777 THR 1778 0.0025

THR 1778 ARG 1779 0.0032

ARG 1779 PRO 1780 0.0013

PRO 1780 ASN 1781 0.0022

ASN 1781 SER 1782 0.0023

SER 1782 SER 1783 0.0013

SER 1783 LEU 1784 0.0035

LEU 1784 LYS 1785 0.0017

LYS 1785 THR 1786 0.0026

THR 1786 GLY 1787 0.0011

GLY 1787 LEU 1788 0.0021

LEU 1788 LEU 1789 -0.0007

LEU 1789 ARG 1790 0.0006

ARG 1790 THR 1791 0.0039

THR 1791 LEU 1792 0.0009

LEU 1792 ARG 1793 0.0041

ARG 1793 LEU 1794 0.0015

LEU 1794 GLU 1795 0.0032

GLU 1795 TYR 1796 0.0015

TYR 1796 THR 1797 0.0039

THR 1797 GLU 1798 0.0010

GLU 1798 LYS 1799 0.0031

LYS 1799 ARG 1800 0.0042

ARG 1800 PHE 1801 0.0040

PHE 1801 ILE 1802 0.0043

ILE 1802 SER 1803 0.0039

SER 1803 LEU 1804 0.0032

LEU 1804 ASP 1805 -0.0124

ASP 1805 LEU 1806 0.0033

LEU 1806 ASP 1807 0.0063

ASP 1807 SER 1808 0.0064

SER 1808 ALA 1809 0.0062

ALA 1809 ARG 1810 0.0014

ARG 1810 PRO 1811 0.0016

PRO 1811 GLN 1812 0.0066

GLN 1812 TRP 1813 0.0027

TRP 1813 ASN 1814 0.0064

ASN 1814 HIS 1815 0.0061

HIS 1815 ASP 1816 0.0006

ASP 1816 SER 1817 0.0058

SER 1817 ILE 1818 0.0038

ILE 1818 THR 1819 0.0059

THR 1819 THR 1820 0.0007

THR 1820 ILE 1821 -0.0037

ILE 1821 ASN 1822 0.0074

ASN 1822 GLU 1823 0.0042

GLU 1823 VAL 1824 0.0057

VAL 1824 LEU 1825 0.0056

LEU 1825 CYS 1826 0.0100

CYS 1826 GLY 1827 0.0000

GLY 1827 ALA 1828 0.0101

ALA 1828 LEU 1829 0.0054

LEU 1829 ALA 1830 0.0095

ALA 1830 GLN 1831 0.0017

GLN 1831 ASN 1832 0.0100

ASN 1832 ALA 1833 0.0043

ALA 1833 ASP 1834 0.0040

ASP 1834 SER 1835 0.0097

SER 1835 SER 1836 0.0038

SER 1836 ILE 1837 0.0549

ILE 1837 LYS 1838 0.0030

LYS 1838 ASP 1839 0.0079

ASP 1839 SER 1840 0.0074

SER 1840 GLU 1841 0.0081

GLU 1841 PHE 1842 0.0060

PHE 1842 ALA 1843 0.0080

ALA 1843 GLU 1844 0.0047

GLU 1844 GLN 1845 0.0072

GLN 1845 ASP 1846 0.0060

ASP 1846 GLY 1847 0.0054

GLY 1847 GLN 1848 0.0039

GLN 1848 LEU 1849 0.0074

LEU 1849 PHE 1850 0.0006

PHE 1850 VAL 1851 0.0053

VAL 1851 PRO 1852 0.0023

PRO 1852 ARG 1853 -0.0056

ARG 1853 ILE 1854 0.0026

ILE 1854 SER 1855 0.0028

SER 1855 CYS 1856 0.0032

CYS 1856 ASP 1857 0.0022

ASP 1857 ILE 1858 0.0022

ILE 1858 ALA 1859 0.0024

ALA 1859 ARG 1860 0.0007

ARG 1860 ASN 1861 0.0029

ASN 1861 GLU 1862 0.0028

GLU 1862 ASP 1863 0.0004

ASP 1863 LEU 1864 0.0027

LEU 1864 SER 1865 0.0020

SER 1865 SER 1866 0.0035

SER 1866 ASP 1867 0.0019

ASP 1867 SER 1868 0.0017

SER 1868 ASN 1869 0.1811

ASN 1869 SER 1870 0.0421

SER 1870 PRO 1871 0.0496

PRO 1871 ALA 1872 0.0532

ALA 1872 GLN 1873 0.0381

GLN 1873 MET 1874 0.0507

MET 1874 GLU 1875 0.0484

GLU 1875 PRO 1876 0.0553

PRO 1876 PHE 1877 0.0310

PHE 1877 HIS 1878 0.0457

HIS 1878 GLN 1879 0.0126

GLN 1879 PRO 1880 0.0425

PRO 1880 GLY 1881 0.0567

GLY 1881 LYS 1882 0.0448

LYS 1882 LEU 1883 0.0102

LEU 1883 LEU 1884 0.0385

LEU 1884 GLN 1885 -0.0112

GLN 1885 MET 1886 0.0280

MET 1886 GLY 1887 0.0452

GLY 1887 ILE 1888 0.0410

ILE 1888 LYS 1889 0.0390

LYS 1889 THR 1890 0.0166

THR 1890 PRO 1891 0.0115

PRO 1891 GLY 1892 0.0309

GLY 1892 LEU 1893 0.0285

LEU 1893 ILE 1894 0.0511

ILE 1894 ASP 1895 0.0218

ASP 1895 THR 1896 0.0366

THR 1896 LEU 1897 0.0511

LEU 1897 GLN 1898 0.0050

GLN 1898 PHE 1899 0.0348

PHE 1899 SER 1900 0.0321

SER 1900 LYS 1901 0.0019

LYS 1901 THR 1902 0.0597

THR 1902 ASP 1903 0.0397

ASP 1903 ALA 1904 0.0607

ALA 1904 THR 1905 0.0611

THR 1905 ASP 1906 0.0528

ASP 1906 ASN 1907 0.0418

ASN 1907 LEU 1908 0.0151

LEU 1908 PRO 1909 0.0393

PRO 1909 ASN 1910 0.0577

ASN 1910 ASP 1911 0.0063

ASP 1911 TYR 1912 0.0588

TYR 1912 ILE 1913 0.0599

ILE 1913 GLU 1914 0.0445

GLU 1914 ILE 1915 0.0520

ILE 1915 GLU 1916 0.0516

GLU 1916 PRO 1917 0.0113

PRO 1917 LYS 1918 0.0520

LYS 1918 ALA 1919 0.0158

ALA 1919 PHE 1920 0.0403

PHE 1920 GLY 1921 0.0042

GLY 1921 LEU 1922 0.0516

LEU 1922 ASN 1923 0.0259

ASN 1923 PHE 1924 0.0363

PHE 1924 ARG 1925 0.0460

ARG 1925 ASP 1926 0.0087

ASP 1926 VAL 1927 0.0472

VAL 1927 MET 1928 0.0419

MET 1928 VAL 1929 0.0145

VAL 1929 ALA 1930 0.0393

ALA 1930 MET 1931 0.0292

MET 1931 GLY 1932 0.0530

GLY 1932 GLN 1933 0.0210

GLN 1933 LEU 1934 0.0522

LEU 1934 GLU 1935 0.0430

GLU 1935 GLU 1936 0.0376

GLU 1936 SER 1937 0.0196

SER 1937 ILE 1938 0.0529

ILE 1938 MET 1939 0.0530

MET 1939 GLY 1940 0.0530

GLY 1940 PHE 1941 0.0316

PHE 1941 GLU 1942 0.0525

GLU 1942 CYS 1943 0.0314

CYS 1943 ALA 1944 0.0517

ALA 1944 GLY 1945 0.0083

GLY 1945 VAL 1946 0.0323

VAL 1946 VAL 1947 0.0505

VAL 1947 ARG 1948 0.0036

ARG 1948 ARG 1949 0.0620

ARG 1949 VAL 1950 0.0418

VAL 1950 GLY 1951 0.0605

GLY 1951 PRO 1952 0.0595

PRO 1952 SER 1953 0.0077

SER 1953 SER 1954 0.0522

SER 1954 ALA 1955 0.0500

ALA 1955 GLY 1956 0.0363

GLY 1956 HIS 1957 0.0248

HIS 1957 ASN 1958 0.0591

ASN 1958 ILE 1959 0.0476

ILE 1959 LYS 1960 0.0127

LYS 1960 VAL 1961 0.0315

VAL 1961 GLY 1962 0.0577

GLY 1962 ASP 1963 0.0014

ASP 1963 ARG 1964 0.0420

ARG 1964 VAL 1965 0.0421

VAL 1965 CYS 1966 0.0356

CYS 1966 ALA 1967 0.0576

ALA 1967 LEU 1968 0.0436

LEU 1968 LEU 1969 0.0340

LEU 1969 GLY 1970 0.0573

GLY 1970 GLY 1971 0.0574

GLY 1971 GLN 1972 0.0154

GLN 1972 TRP 1973 0.0550

TRP 1973 THR 1974 0.0115

THR 1974 ASN 1975 0.0372

ASN 1975 THR 1976 0.0575

THR 1976 VAL 1977 0.0216

VAL 1977 ARG 1978 0.0577

ARG 1978 VAL 1979 0.0136

VAL 1979 HIS 1980 0.0501

HIS 1980 TRP 1981 0.0506

TRP 1981 HIS 1982 0.0026

HIS 1982 SER 1983 0.0589

SER 1983 VAL 1984 0.0510

VAL 1984 ALA 1985 0.0485

ALA 1985 PRO 1986 0.0512

PRO 1986 ILE 1987 0.0545

ILE 1987 PRO 1988 0.0562

PRO 1988 GLN 1989 0.0245

GLN 1989 ALA 1990 0.0438

ALA 1990 MET 1991 0.0565

MET 1991 ASP 1992 0.0432

ASP 1992 TRP 1993 0.0513

TRP 1993 GLU 1994 0.0373

GLU 1994 THR 1995 0.0188

THR 1995 ALA 1996 0.0499

ALA 1996 ALA 1997 0.0511

ALA 1997 SER 1998 0.0096

SER 1998 ILE 1999 0.0455

ILE 1999 PRO 2000 0.0505

PRO 2000 ILE 2001 0.0489

ILE 2001 VAL 2002 0.0190

VAL 2002 PHE 2003 0.0493

PHE 2003 VAL 2004 0.0516

VAL 2004 THR 2005 0.0446

THR 2005 ALA 2006 0.0190

ALA 2006 TYR 2007 0.0554

TYR 2007 ILE 2008 0.0546

ILE 2008 SER 2009 0.0292

SER 2009 LEU 2010 0.0280

LEU 2010 VAL 2011 0.0538

VAL 2011 LYS 2012 0.0462

LYS 2012 ILE 2013 0.0502

ILE 2013 ALA 2014 0.0139

ALA 2014 ARG 2015 0.0529

ARG 2015 MET 2016 0.0391

MET 2016 GLN 2017 0.0309

GLN 2017 ALA 2018 0.0444

ALA 2018 GLY 2019 0.0223

GLY 2019 GLU 2020 0.0485

GLU 2020 THR 2021 0.0537

THR 2021 VAL 2022 0.0136

VAL 2022 LEU 2023 0.0503

LEU 2023 ILE 2024 0.0072

ILE 2024 HIS 2025 0.0449

HIS 2025 ALA 2026 0.0289

ALA 2026 ALA 2027 0.0495

ALA 2027 SER 2028 0.0377

SER 2028 GLY 2029 0.0108

GLY 2029 GLY 2030 0.0413

GLY 2030 VAL 2031 0.0457

VAL 2031 GLY 2032 0.0110

GLY 2032 GLN 2033 0.0548

GLN 2033 ALA 2034 0.0486

ALA 2034 ALA 2035 0.0214

ALA 2035 ILE 2036 0.0355

ILE 2036 ILE 2037 0.0447

ILE 2037 LEU 2038 0.0552

LEU 2038 ALA 2039 0.0072

ALA 2039 LYS 2040 0.0519

LYS 2040 HIS 2041 0.0435

HIS 2041 VAL 2042 0.0403

VAL 2042 GLY 2043 0.0180

GLY 2043 ALA 2044 0.0535

ALA 2044 GLU 2045 0.0616

GLU 2045 ILE 2046 0.0366

ILE 2046 PHE 2047 0.0548

PHE 2047 ALA 2048 0.0232

ALA 2048 THR 2049 0.0502

THR 2049 VAL 2050 0.0345

VAL 2050 GLY 2051 0.0486

GLY 2051 THR 2052 0.0548

THR 2052 ASP 2053 0.0408

ASP 2053 GLU 2054 0.0216

GLU 2054 LYS 2055 0.0552

LYS 2055 ARG 2056 0.0023

ARG 2056 ASP 2057 0.0552

ASP 2057 LEU 2058 0.0281

LEU 2058 LEU 2059 0.0366

LEU 2059 ILE 2060 0.0259

ILE 2060 LYS 2061 0.0377

LYS 2061 GLU 2062 0.0314

GLU 2062 TYR 2063 0.0443

TYR 2063 LYS 2064 0.0063

LYS 2064 ILE 2065 0.0510

ILE 2065 PRO 2066 0.0120

PRO 2066 ASP 2067 0.0560

ASP 2067 ASP 2068 0.0300

ASP 2068 HIS 2069 0.0344

HIS 2069 ILE 2070 0.0266

ILE 2070 PHE 2071 0.0559

PHE 2071 SER 2072 0.0376

SER 2072 SER 2073 0.0298

SER 2073 ARG 2074 0.0559

ARG 2074 ASN 2075 0.0112

ASN 2075 ALA 2076 0.0380

ALA 2076 LEU 2077 0.0131

LEU 2077 PHE 2078 0.0481

PHE 2078 ALA 2079 0.0467

ALA 2079 LYS 2080 0.0063

LYS 2080 SER 2081 0.0514

SER 2081 ILE 2082 0.0462

ILE 2082 ARG 2083 0.0275

ARG 2083 GLN 2084 0.0258

GLN 2084 ARG 2085 0.0459

ARG 2085 THR 2086 0.0515

THR 2086 ASN 2087 0.0060

ASN 2087 GLY 2088 0.0453

GLY 2088 LYS 2089 0.0377

LYS 2089 GLY 2090 0.0099

GLY 2090 VAL 2091 0.0197

VAL 2091 ASP 2092 0.0469

ASP 2092 VAL 2093 0.0216

VAL 2093 VAL 2094 0.0380

VAL 2094 LEU 2095 0.0046

LEU 2095 ASN 2096 0.0474

ASN 2096 CYS 2097 0.0178

CYS 2097 LEU 2098 0.0426

LEU 2098 ALA 2099 0.0495

ALA 2099 GLY 2100 0.0377

GLY 2100 GLY 2101 0.0033

GLY 2101 LEU 2102 0.0517

LEU 2102 LEU 2103 0.0485

LEU 2103 GLN 2104 0.0199

GLN 2104 GLU 2105 0.0333

GLU 2105 SER 2106 0.0450

SER 2106 PHE 2107 0.0501

PHE 2107 ASP 2108 0.0072

ASP 2108 CYS 2109 0.0554

CYS 2109 LEU 2110 0.0463

LEU 2110 ALA 2111 0.0212

ALA 2111 ASP 2112 0.0435

ASP 2112 PHE 2113 0.0256

PHE 2113 GLY 2114 0.0313

GLY 2114 ARG 2115 0.0000

ARG 2115 PHE 2116 0.0327

PHE 2116 ILE 2117 0.0052

ILE 2117 GLU 2118 0.0286

GLU 2118 ILE 2119 0.0133

ILE 2119 GLY 2120 0.0453

GLY 2120 LYS 2121 0.0268

LYS 2121 ARG 2122 0.0470

ARG 2122 ASP 2123 0.0187

ASP 2123 ILE 2124 0.0422

ILE 2124 GLU 2125 0.0100

GLU 2125 LEU 2126 0.0382

LEU 2126 ASN 2127 0.0310

ASN 2127 HIS 2128 0.0159

HIS 2128 CYS 2129 0.0113

CYS 2129 LEU 2130 0.0286

LEU 2130 ASN 2131 0.0017

ASN 2131 MET 2132 0.0448

MET 2132 GLY 2133 0.0042

GLY 2133 MET 2134 0.0468

MET 2134 PHE 2135 0.0452

PHE 2135 ALA 2136 0.0046

ALA 2136 ARG 2137 0.0461

ARG 2137 SER 2138 0.0296

SER 2138 ALA 2139 0.0288

ALA 2139 THR 2140 0.0053

THR 2140 PHE 2141 0.0065

PHE 2141 THR 2142 0.0092

THR 2142 ALA 2143 0.0125

ALA 2143 VAL 2144 0.0316

VAL 2144 ASP 2145 0.0018

ASP 2145 LEU 2146 0.0354

LEU 2146 ILE 2147 0.0163

ILE 2147 ALA 2148 0.0437

ALA 2148 ILE 2149 0.0451

ILE 2149 GLY 2150 0.0110

GLY 2150 ARG 2151 0.0415

ARG 2151 ASP 2152 0.0306

ASP 2152 ARG 2153 0.0365

ARG 2153 SER 2154 0.0344

SER 2154 TYR 2155 0.0404

TYR 2155 MET 2156 0.0243

MET 2156 PHE 2157 0.0364

PHE 2157 ALA 2158 0.0505

ALA 2158 GLU 2159 0.0054

GLU 2159 ALA 2160 0.0512

ALA 2160 LEU 2161 0.0246

LEU 2161 PRO 2162 0.0554

PRO 2162 LYS 2163 0.0018

LYS 2163 ILE 2164 0.0563

ILE 2164 MET 2165 0.0251

MET 2165 THR 2166 0.0443

THR 2166 LEU 2167 0.0186

LEU 2167 LEU 2168 0.0410

LEU 2168 GLN 2169 0.0448

GLN 2169 GLU 2170 0.0141

GLU 2170 LYS 2171 0.0509

LYS 2171 ALA 2172 0.0244

ALA 2172 ILE 2173 0.0505

ILE 2173 ARG 2174 0.0414

ARG 2174 PRO 2175 0.0326

PRO 2175 VAL 2176 0.0514

VAL 2176 THR 2177 0.0549

THR 2177 PRO 2178 0.0406

PRO 2178 ILE 2179 0.0114

ILE 2179 SER 2180 0.0438

SER 2180 ILE 2181 0.0016

ILE 2181 TYR 2182 0.0313

TYR 2182 LYS 2183 0.0014

LYS 2183 ILE 2184 0.0482

ILE 2184 GLY 2185 0.0427

GLY 2185 ASP 2186 0.0125

ASP 2186 ILE 2187 0.0463

ILE 2187 GLU 2188 0.0520

GLU 2188 THR 2189 0.0030

THR 2189 ALA 2190 0.0435

ALA 2190 PHE 2191 0.0533

PHE 2191 ARG 2192 0.0470

ARG 2192 LEU 2193 0.0343

LEU 2193 MET 2194 0.0485

MET 2194 GLN 2195 0.0538

GLN 2195 ALA 2196 0.0379

ALA 2196 GLY 2197 0.0360

GLY 2197 LYS 2198 0.0540

LYS 2198 HIS 2199 0.0484

HIS 2199 MET 2200 0.0378

MET 2200 GLY 2201 0.0511

GLY 2201 LYS 2202 0.0093

LYS 2202 ILE 2203 0.0145

ILE 2203 VAL 2204 0.0201

VAL 2204 ILE 2205 -0.0314

ILE 2205 THR 2206 0.0282

THR 2206 ALA 2207 0.0071

ALA 2207 PRO 2208 0.0427

PRO 2208 GLU 2209 0.0013

GLU 2209 ASP 2210 0.0612

ASP 2210 ALA 2211 0.0342

ALA 2211 MET 2212 0.0565

MET 2212 VAL 2213 0.0513

VAL 2213 PRO 2214 0.0610

PRO 2214 VAL 2215 0.0419

VAL 2215 ILE 2216 0.0580

ILE 2216 THR 2217 0.0173

THR 2217 ARG 2218 0.0609

ARG 2218 PRO 2219 0.0176

PRO 2219 PRO 2220 0.0562

PRO 2220 LYS 2221 -0.1201

LYS 2221 LEU 2222 0.0010

LEU 2222 GLN 2223 0.0002

GLN 2223 LEU 2224 0.0008

LEU 2224 ARG 2225 0.0005

ARG 2225 PRO 2226 0.0005

PRO 2226 ASP 2227 0.0011

ASP 2227 ALA 2228 0.0014

ALA 2228 SER 2229 0.0018

SER 2229 TYR 2230 0.0004

TYR 2230 LEU 2231 0.0019

LEU 2231 ILE 2232 0.0010

ILE 2232 VAL 2233 0.0017

VAL 2233 GLY 2234 0.0017

GLY 2234 GLY 2235 0.0014

GLY 2235 LEU 2236 0.0016

LEU 2236 GLY 2237 0.0148

GLY 2237 GLY 2238 0.0008

GLY 2238 ILE 2239 0.0012

ILE 2239 GLY 2240 0.0009

GLY 2240 ARG 2241 0.0018

ARG 2241 SER 2242 0.0004

SER 2242 LEU 2243 0.0021

LEU 2243 CYS 2244 0.0006

CYS 2244 LYS 2245 0.0020

LYS 2245 ASN 2246 0.0004

ASN 2246 PHE 2247 0.0019

PHE 2247 VAL 2248 0.0014

VAL 2248 GLU 2249 0.0009

GLU 2249 ASN 2250 0.0016

ASN 2250 GLY 2251 0.0008

GLY 2251 ALA 2252 0.0013

ALA 2252 ARG 2253 -0.0238

ARG 2253 SER 2254 0.0022

SER 2254 LEU 2255 0.0025

LEU 2255 VAL 2256 0.0022

VAL 2256 LEU 2257 0.0026

LEU 2257 LEU 2258 0.0025

LEU 2258 SER 2259 0.0025

SER 2259 ARG 2260 0.0020

ARG 2260 ASN 2261 0.0016

ASN 2261 ALA 2262 0.0023

ALA 2262 ASN 2263 0.0007

ASN 2263 VAL 2264 0.0020

VAL 2264 SER 2265 0.0023

SER 2265 GLN 2266 0.0023

GLN 2266 GLN 2267 0.0003

GLN 2267 SER 2268 0.0021

SER 2268 GLY 2269 -0.0294

GLY 2269 GLU 2270 0.0040

GLU 2270 PHE 2271 0.0008

PHE 2271 LEU 2272 0.0038

LEU 2272 ASP 2273 0.0029

ASP 2273 GLU 2274 0.0015

GLU 2274 LEU 2275 0.0036

LEU 2275 ARG 2276 0.0018

ARG 2276 SER 2277 0.0044

SER 2277 THR 2278 0.0009

THR 2278 GLY 2279 0.0037

GLY 2279 CYS 2280 0.0034

CYS 2280 ILE 2281 0.0037

ILE 2281 VAL 2282 0.0046

VAL 2282 GLY 2283 0.0042

GLY 2283 VAL 2284 0.0045

VAL 2284 VAL 2285 0.0536

VAL 2285 ASP 2286 0.0019

ASP 2286 CYS 2287 0.0008

CYS 2287 ASP 2288 0.0008

ASP 2288 ILE 2289 0.0013

ILE 2289 SER 2290 0.0014

SER 2290 SER 2291 0.0006

SER 2291 LYS 2292 0.0019

LYS 2292 THR 2293 0.0000

THR 2293 GLN 2294 0.0017

GLN 2294 VAL 2295 0.0014

VAL 2295 GLU 2296 0.0015

GLU 2296 ALA 2297 0.0005

ALA 2297 THR 2298 0.0018

THR 2298 MET 2299 0.0018

MET 2299 LEU 2300 0.0004

LEU 2300 ARG 2301 0.0299

ARG 2301 LEU 2302 0.0008

LEU 2302 LYS 2303 0.0013

LYS 2303 LYS 2304 -0.0000

LYS 2304 ASP 2305 0.0012

ASP 2305 MET 2306 0.0004

MET 2306 LEU 2307 0.0009

LEU 2307 PRO 2308 0.0006

PRO 2308 ILE 2309 0.0008

ILE 2309 ARG 2310 0.0001

ARG 2310 GLY 2311 0.0010

GLY 2311 ILE 2312 0.0012

ILE 2312 VAL 2313 0.0009

VAL 2313 HIS 2314 0.0013

HIS 2314 ALA 2315 0.0012

ALA 2315 GLY 2316 0.0009

GLY 2316 MET 2317 -0.1101

MET 2317 VAL 2318 0.0022

VAL 2318 LEU 2319 0.0025

LEU 2319 GLN 2320 0.0015

GLN 2320 ASP 2321 0.0023

ASP 2321 SER 2322 0.0007

SER 2322 VAL 2323 0.0013

VAL 2323 PHE 2324 0.0013

PHE 2324 GLU 2325 0.0016

GLU 2325 ARG 2326 0.0015

ARG 2326 MET 2327 0.0023

MET 2327 SER 2328 0.0027

SER 2328 LEU 2329 0.0025

LEU 2329 ASP 2330 0.0005

ASP 2330 ASP 2331 0.0021

ASP 2331 TYR 2332 0.0019

TYR 2332 ASN 2333 -0.0343

ASN 2333 THR 2334 -0.0000

THR 2334 ALA 2335 0.0012

ALA 2335 ILE 2336 0.0011

ILE 2336 ARG 2337 0.0010

ARG 2337 PRO 2338 0.0001

PRO 2338 LYS 2339 0.0009

LYS 2339 VAL 2340 0.0004

VAL 2340 GLN 2341 0.0012

GLN 2341 GLY 2342 0.0001

GLY 2342 SER 2343 0.0013

SER 2343 TRP 2344 0.0008

TRP 2344 ASN 2345 0.0009

ASN 2345 LEU 2346 0.0006

LEU 2346 HIS 2347 0.0006

HIS 2347 SER 2348 0.0011

SER 2348 GLY 2349 0.0339

GLY 2349 LEU 2350 0.0012

LEU 2350 SER 2351 0.0012

SER 2351 ASP 2352 -0.0000

ASP 2352 CYS 2353 0.0014

CYS 2353 ASP 2354 0.0013

ASP 2354 LEU 2355 0.0011

LEU 2355 ASP 2356 0.0014

ASP 2356 PHE 2357 0.0008

PHE 2357 PHE 2358 0.0009

PHE 2358 ILE 2359 0.0008

ILE 2359 MET 2360 0.0009

MET 2360 LEU 2361 0.0012

LEU 2361 SER 2362 0.0001

SER 2362 SER 2363 0.0007

SER 2363 LEU 2364 0.0004

LEU 2364 ALA 2365 0.0206

ALA 2365 GLY 2366 0.0015

GLY 2366 VAL 2367 0.0020

VAL 2367 SER 2368 0.0020

SER 2368 GLY 2369 0.0016

GLY 2369 SER 2370 0.0020

SER 2370 ALA 2371 0.0013

ALA 2371 SER 2372 0.0023

SER 2372 GLN 2373 0.0020

GLN 2373 ALA 2374 0.0004

ALA 2374 ASN 2375 0.0023

ASN 2375 TYR 2376 0.0003

TYR 2376 THR 2377 0.0020

THR 2377 ALA 2378 0.0010

ALA 2378 GLY 2379 0.0013

GLY 2379 GLY 2380 0.0015

GLY 2380 ALA 2381 0.0109

ALA 2381 TYR 2382 0.0010

TYR 2382 GLN 2383 0.0001

GLN 2383 ASP 2384 0.0010

ASP 2384 ALA 2385 0.0005

ALA 2385 LEU 2386 0.0007

LEU 2386 ALA 2387 0.0005

ALA 2387 LYS 2388 0.0005

LYS 2388 TYR 2389 0.0009

TYR 2389 ARG 2390 0.0002

ARG 2390 ARG 2391 0.0010

ARG 2391 ALA 2392 0.0004

ALA 2392 GLN 2393 0.0008

GLN 2393 GLY 2394 0.0003

GLY 2394 LEU 2395 0.0009

LEU 2395 SER 2396 0.0006

SER 2396 ALA 2397 -0.0097

ALA 2397 VAL 2398 0.0007

VAL 2398 SER 2399 0.0009

SER 2399 ILE 2400 0.0003

ILE 2400 ASP 2401 0.0009

ASP 2401 LEU 2402 0.0000

LEU 2402 GLY 2403 0.0007

GLY 2403 MET 2404 0.0003

MET 2404 VAL 2405 0.0003

VAL 2405 GLN 2406 0.0001

GLN 2406 SER 2407 0.0003

SER 2407 VAL 2408 0.0007

VAL 2408 GLY 2409 0.0007

GLY 2409 TYR 2410 0.0009

TYR 2410 VAL 2411 0.0011

VAL 2411 ALA 2412 0.0004

ALA 2412 GLU 2413 0.0362

GLU 2413 THR 2414 0.0006

THR 2414 LYS 2415 0.0006

LYS 2415 GLY 2416 0.0004

GLY 2416 VAL 2417 0.0004

VAL 2417 ALA 2418 0.0007

ALA 2418 GLU 2419 0.0006

GLU 2419 ARG 2420 -0.0001

ARG 2420 LEU 2421 0.0006

LEU 2421 VAL 2422 0.0004

VAL 2422 ARG 2423 0.0007

ARG 2423 MET 2424 0.0002

MET 2424 GLY 2425 0.0007

GLY 2425 TYR 2426 0.0006

TYR 2426 SER 2427 0.0004

SER 2427 PRO 2428 0.0004

PRO 2428 ILE 2429 -0.0111

ILE 2429 SER 2430 0.0002

SER 2430 GLU 2431 0.0002

GLU 2431 MET 2432 -0.0000

MET 2432 GLU 2433 0.0000

GLU 2433 VAL 2434 0.0001

VAL 2434 LEU 2435 0.0003

LEU 2435 LYS 2436 0.0000

LYS 2436 ILE 2437 0.0001

ILE 2437 VAL 2438 0.0002

VAL 2438 GLU 2439 0.0003

GLU 2439 HIS 2440 0.0002

HIS 2440 ALA 2441 -0.0000

ALA 2441 ILE 2442 0.0001

ILE 2442 THR 2443 -0.0002

THR 2443 ASN 2444 0.0000

ASN 2444 PRO 2445 -0.0230

PRO 2445 PRO 2446 0.0004

PRO 2446 PRO 2447 0.0008

PRO 2447 GLU 2448 0.0003

GLU 2448 ALA 2449 0.0005

ALA 2449 SER 2450 0.0005

SER 2450 SER 2451 0.0009

SER 2451 ALA 2452 0.0011

ALA 2452 GLN 2453 0.0005

GLN 2453 ILE 2454 0.0011

ILE 2454 ILE 2455 0.0005

ILE 2455 THR 2456 0.0010

THR 2456 GLY 2457 0.0008

GLY 2457 ILE 2458 0.0007

ILE 2458 SER 2459 0.0010

SER 2459 THR 2460 0.0010

THR 2460 LYS 2461 0.0264

LYS 2461 PRO 2462 0.0033

PRO 2462 GLY 2463 0.0025

GLY 2463 ARG 2464 0.0012

ARG 2464 HIS 2465 0.0025

HIS 2465 TRP 2466 0.0031

TRP 2466 THR 2467 0.0025

THR 2467 GLU 2468 0.0030

GLU 2468 SER 2469 0.0030

SER 2469 SER 2470 0.0003

SER 2470 TRP 2471 0.0033

TRP 2471 LEU 2472 0.0015

LEU 2472 GLN 2473 0.0020

GLN 2473 ASP 2474 0.0024

ASP 2474 ALA 2475 0.0030

ALA 2475 ARG 2476 0.0028

ARG 2476 PHE 2477 0.0142

PHE 2477 ALA 2478 0.0082

ALA 2478 THR 2479 0.0042

THR 2479 LEU 2480 0.0054

LEU 2480 ARG 2481 0.0083

ARG 2481 GLU 2482 0.0071

GLU 2482 ARG 2483 0.0037

ARG 2483 ALA 2484 0.0080

ALA 2484 ARG 2485 0.0084

ARG 2485 ASP 2486 0.0051

ASP 2486 VAL 2487 0.0051

VAL 2487 LYS 2488 0.0082

LYS 2488 GLU 2489 0.0083

GLU 2489 LEU 2490 0.0039

LEU 2490 SER 2491 0.0068

SER 2491 ASN 2492 0.0084

ASN 2492 SER 2493 -0.0356

SER 2493 GLN 2494 0.0019

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** sdgklnrdh ***

CA strain for 22101813491974862

--- normal mode 11 ---

Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *