Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *

CA strain for 22101813491974862

--- normal mode 10 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
ASN 989 LYS 990 0.0054

LYS 990 ALA 991 0.0023

ALA 991 HIS 992 0.0037

HIS 992 ARG 993 0.0034

ARG 993 GLN 994 0.0030

GLN 994 ARG 995 0.0045

ARG 995 VAL 996 0.0050

VAL 996 HIS 997 0.0054

HIS 997 PRO 998 0.0037

PRO 998 PRO 999 0.0053

PRO 999 HIS 1000 0.0029

HIS 1000 ASP 1001 0.0057

ASP 1001 LEU 1002 0.0004

LEU 1002 LEU 1003 0.0055

LEU 1003 GLY 1004 0.0014

GLY 1004 SER 1005 -0.0231

SER 1005 LEU 1006 0.0035

LEU 1006 ILE 1007 0.0054

ILE 1007 VAL 1008 0.0046

VAL 1008 GLY 1009 0.0046

GLY 1009 ARG 1010 0.0006

ARG 1010 ASP 1011 0.0023

ASP 1011 LEU 1012 0.0053

LEU 1012 ARG 1013 0.0000

ARG 1013 GLU 1014 0.0053

GLU 1014 PRO 1015 0.0021

PRO 1015 THR 1016 0.0044

THR 1016 TRP 1017 0.0032

TRP 1017 ARG 1018 0.0032

ARG 1018 HIS 1019 0.0049

HIS 1019 PHE 1020 0.0032

PHE 1020 ILE 1021 -0.1587

ILE 1021 ARG 1022 0.0004

ARG 1022 VAL 1023 0.0023

VAL 1023 GLN 1024 0.0003

GLN 1024 ASP 1025 0.0020

ASP 1025 ILE 1026 0.0011

ILE 1026 PRO 1027 0.0021

PRO 1027 TRP 1028 0.0009

TRP 1028 ILE 1029 0.0015

ILE 1029 ARG 1030 0.0019

ARG 1030 ASP 1031 0.0020

ASP 1031 HIS 1032 0.0003

HIS 1032 VAL 1033 0.0019

VAL 1033 VAL 1034 0.0004

VAL 1034 GLN 1035 0.0022

GLN 1035 SER 1036 0.0001

SER 1036 ALA 1037 -0.0925

ALA 1037 LEU 1038 0.0036

LEU 1038 VAL 1039 0.0010

VAL 1039 TYR 1040 0.0037

TYR 1040 PRO 1041 0.0013

PRO 1041 GLY 1042 0.0009

GLY 1042 ALA 1043 0.0038

ALA 1043 GLY 1044 0.0016

GLY 1044 PHE 1045 0.0028

PHE 1045 ILE 1046 0.0017

ILE 1046 CYS 1047 0.0020

CYS 1047 MET 1048 0.0032

MET 1048 ALA 1049 0.0009

ALA 1049 MET 1050 0.0037

MET 1050 GLU 1051 0.0007

GLU 1051 ALA 1052 0.0035

ALA 1052 MET 1053 -0.0393

MET 1053 VAL 1054 0.0039

VAL 1054 GLN 1055 0.0021

GLN 1055 LEU 1056 0.0035

LEU 1056 HIS 1057 0.0045

HIS 1057 GLU 1058 0.0011

GLU 1058 LEU 1059 0.0049

LEU 1059 ARG 1060 0.0020

ARG 1060 ASP 1061 0.0046

ASP 1061 SER 1062 0.0038

SER 1062 GLN 1063 0.0017

GLN 1063 SER 1064 0.0055

SER 1064 ARG 1065 0.0010

ARG 1065 LYS 1066 0.0055

LYS 1066 VAL 1067 0.0055

VAL 1067 ALA 1068 0.0021

ALA 1068 GLY 1069 -0.0118

GLY 1069 TYR 1070 0.0043

TYR 1070 ARG 1071 0.0019

ARG 1071 LEU 1072 0.0042

LEU 1072 ALA 1073 0.0024

ALA 1073 GLU 1074 0.0043

GLU 1074 VAL 1075 0.0008

VAL 1075 ASP 1076 0.0039

ASP 1076 ILE 1077 0.0013

ILE 1077 LEU 1078 0.0041

LEU 1078 ARG 1079 0.0011

ARG 1079 ALA 1080 0.0019

ALA 1080 MET 1081 0.0014

MET 1081 LEU 1082 0.0016

LEU 1082 ILE 1083 0.0014

ILE 1083 PRO 1084 0.0010

PRO 1084 ASP 1085 0.0488

ASP 1085 THR 1086 0.0024

THR 1086 SER 1087 0.0029

SER 1087 GLU 1088 0.0035

GLU 1088 GLY 1089 0.0011

GLY 1089 LEU 1090 0.0010

LEU 1090 GLU 1091 0.0046

GLU 1091 ALA 1092 0.0009

ALA 1092 HIS 1093 0.0038

HIS 1093 ILE 1094 0.0020

ILE 1094 SER 1095 0.0035

SER 1095 LEU 1096 0.0027

LEU 1096 ARG 1097 0.0026

ARG 1097 PRO 1098 0.0024

PRO 1098 CYS 1099 0.0007

CYS 1099 SER 1100 0.0038

SER 1100 THR 1101 0.0130

THR 1101 LYS 1102 0.0020

LYS 1102 LEU 1103 0.0052

LEU 1103 LEU 1104 0.0030

LEU 1104 LEU 1105 0.0025

LEU 1105 THR 1106 0.0048

THR 1106 ASN 1107 0.0003

ASN 1107 GLU 1108 0.0016

GLU 1108 TRP 1109 0.0049

TRP 1109 TYR 1110 0.0025

TYR 1110 ASP 1111 0.0048

ASP 1111 PHE 1112 0.0017

PHE 1112 CYS 1113 0.0044

CYS 1113 VAL 1114 0.0023

VAL 1114 SER 1115 0.0039

SER 1115 SER 1116 0.0016

SER 1116 VAL 1117 0.0028

VAL 1117 GLY 1118 0.0049

GLY 1118 ASP 1119 0.0020

ASP 1119 ASP 1120 0.0037

ASP 1120 ASP 1121 0.0050

ASP 1121 LYS 1122 0.0001

LYS 1122 PHE 1123 0.0041

PHE 1123 VAL 1124 0.0038

VAL 1124 ASP 1125 0.0028

ASP 1125 HIS 1126 0.0053

HIS 1126 CYS 1127 0.0035

CYS 1127 ARG 1128 0.0029

ARG 1128 GLY 1129 0.0035

GLY 1129 ARG 1130 0.0048

ARG 1130 ILE 1131 0.0044

ILE 1131 THR 1132 0.0050

THR 1132 ILE 1133 0.0128

ILE 1133 GLU 1134 0.0015

GLU 1134 PHE 1135 0.0064

PHE 1135 ASP 1136 0.0043

ASP 1136 THR 1137 0.0024

THR 1137 SER 1138 0.0055

SER 1138 GLY 1139 0.0007

GLY 1139 SER 1140 0.0060

SER 1140 ALA 1141 0.0052

ALA 1141 ASP 1142 0.0055

ASP 1142 THR 1143 0.0056

THR 1143 PRO 1144 0.0065

PRO 1144 ARG 1145 0.0033

ARG 1145 THR 1146 0.0046

THR 1146 SER 1147 0.0058

SER 1147 LEU 1148 0.0054

LEU 1148 ARG 1149 0.0793

ARG 1149 GLU 1150 0.0091

GLU 1150 ARG 1151 0.0061

ARG 1151 SER 1152 0.0091

SER 1152 ARG 1153 0.0085

ARG 1153 SER 1154 0.0097

SER 1154 THR 1155 0.0125

THR 1155 GLY 1156 0.0000

GLY 1156 LEU 1157 0.0056

LEU 1157 MET 1158 0.0107

MET 1158 ARG 1159 0.0002

ARG 1159 SER 1160 0.0114

SER 1160 VAL 1161 0.0047

VAL 1161 ASP 1162 0.0077

ASP 1162 PRO 1163 0.0139

PRO 1163 SER 1164 0.0003

SER 1164 ASN 1165 0.0698

ASN 1165 LEU 1166 0.0006

LEU 1166 TYR 1167 0.0009

TYR 1167 SER 1168 0.0004

SER 1168 PHE 1169 0.0011

PHE 1169 LEU 1170 0.0012

LEU 1170 ARG 1171 0.0004

ARG 1171 ALA 1172 0.0011

ALA 1172 GLN 1173 0.0006

GLN 1173 GLY 1174 0.0013

GLY 1174 ILE 1175 0.0008

ILE 1175 TYR 1176 0.0008

TYR 1176 HIS 1177 0.0010

HIS 1177 GLY 1178 0.0009

GLY 1178 PRO 1179 0.0014

PRO 1179 ILE 1180 0.0005

ILE 1180 PHE 1181 0.0199

PHE 1181 GLN 1182 0.0042

GLN 1182 ASN 1183 0.0013

ASN 1183 LEU 1184 0.0030

LEU 1184 LYS 1185 0.0038

LYS 1185 THR 1186 0.0026

THR 1186 ILE 1187 0.0037

ILE 1187 SER 1188 0.0015

SER 1188 SER 1189 0.0041

SER 1189 ARG 1190 0.0027

ARG 1190 LYS 1191 0.0041

LYS 1191 ASP 1192 0.0032

ASP 1192 HIS 1193 0.0041

HIS 1193 SER 1194 0.0030

SER 1194 GLU 1195 0.0041

GLU 1195 SER 1196 0.0013

SER 1196 SER 1197 -0.0258

SER 1197 PHE 1198 0.0010

PHE 1198 VAL 1199 0.0020

VAL 1199 VAL 1200 0.0034

VAL 1200 ALA 1201 0.0005

ALA 1201 ASN 1202 0.0013

ASN 1202 THR 1203 0.0033

THR 1203 ALA 1204 0.0026

ALA 1204 SER 1205 0.0025

SER 1205 VAL 1206 0.0034

VAL 1206 MET 1207 0.0036

MET 1207 PRO 1208 0.0008

PRO 1208 ASN 1209 0.0038

ASN 1209 GLY 1210 0.0007

GLY 1210 PHE 1211 0.0033

PHE 1211 GLN 1212 0.0009

GLN 1212 SER 1213 0.0123

SER 1213 PRO 1214 0.0010

PRO 1214 HIS 1215 0.0017

HIS 1215 VAL 1216 0.0002

VAL 1216 ILE 1217 0.0033

ILE 1217 HIS 1218 0.0010

HIS 1218 PRO 1219 0.0036

PRO 1219 THR 1220 0.0029

THR 1220 THR 1221 0.0013

THR 1221 LEU 1222 0.0017

LEU 1222 ASP 1223 0.0028

ASP 1223 SER 1224 0.0034

SER 1224 ILE 1225 0.0002

ILE 1225 PHE 1226 0.0033

PHE 1226 GLN 1227 0.0025

GLN 1227 GLY 1228 0.0018

GLY 1228 ALA 1229 -0.0250

ALA 1229 TYR 1230 0.0008

TYR 1230 THR 1231 0.0017

THR 1231 ALA 1232 0.0013

ALA 1232 LEU 1233 0.0010

LEU 1233 PRO 1234 0.0019

PRO 1234 GLY 1235 0.0017

GLY 1235 ALA 1236 0.0020

ALA 1236 GLY 1237 0.0013

GLY 1237 LEU 1238 0.0008

LEU 1238 ASP 1239 0.0021

ASP 1239 GLN 1240 0.0024

GLN 1240 ASN 1241 0.0010

ASN 1241 THR 1242 0.0022

THR 1242 ALA 1243 0.0022

ALA 1243 MET 1244 0.0004

MET 1244 ILE 1245 -0.0905

ILE 1245 PRO 1246 0.0024

PRO 1246 ARG 1247 0.0028

ARG 1247 SER 1248 0.0015

SER 1248 ILE 1249 0.0027

ILE 1249 GLN 1250 0.0003

GLN 1250 GLU 1251 0.0032

GLU 1251 LEU 1252 0.0018

LEU 1252 TYR 1253 0.0036

TYR 1253 LEU 1254 0.0017

LEU 1254 SER 1255 0.0033

SER 1255 SER 1256 0.0019

SER 1256 ALA 1257 0.0033

ALA 1257 LEU 1258 0.0021

LEU 1258 THR 1259 0.0008

THR 1259 SER 1260 0.0008

SER 1260 ASP 1261 0.0226

ASP 1261 VAL 1262 0.0008

VAL 1262 GLY 1263 0.0026

GLY 1263 GLN 1264 0.0002

GLN 1264 CYS 1265 0.0026

CYS 1265 LEU 1266 0.0025

LEU 1266 VAL 1267 0.0025

VAL 1267 SER 1268 0.0028

SER 1268 ASP 1269 0.0019

ASP 1269 THR 1270 0.0023

THR 1270 SER 1271 0.0022

SER 1271 LEU 1272 0.0022

LEU 1272 ILE 1273 0.0023

ILE 1273 ARG 1274 0.0014

ARG 1274 TYR 1275 0.0007

TYR 1275 ASP 1276 0.0019

ASP 1276 GLY 1277 -0.0187

GLY 1277 GLN 1278 0.0025

GLN 1278 SER 1279 0.0016

SER 1279 PHE 1280 0.0015

PHE 1280 THR 1281 0.0013

THR 1281 VAL 1282 0.0027

VAL 1282 ASN 1283 0.0015

ASN 1283 VAL 1284 0.0024

VAL 1284 ASP 1285 0.0021

ASP 1285 VAL 1286 0.0020

VAL 1286 SER 1287 0.0025

SER 1287 SER 1288 0.0026

SER 1288 LYS 1289 0.0027

LYS 1289 ALA 1290 0.0026

ALA 1290 ASP 1291 0.0008

ASP 1291 SER 1292 0.0015

SER 1292 GLU 1293 0.0200

GLU 1293 HIS 1294 0.0014

HIS 1294 THR 1295 0.0029

THR 1295 PRO 1296 0.0020

PRO 1296 VAL 1297 0.0016

VAL 1297 LEU 1298 0.0025

LEU 1298 GLU 1299 0.0024

GLU 1299 ILE 1300 0.0025

ILE 1300 LYS 1301 0.0022

LYS 1301 GLY 1302 0.0022

GLY 1302 LEU 1303 0.0005

LEU 1303 ARG 1304 0.0022

ARG 1304 ASN 1305 0.0005

ASN 1305 GLN 1306 0.0022

GLN 1306 SER 1307 0.0010

SER 1307 VAL 1308 0.0008

VAL 1308 GLY 1309 -0.2370

GLY 1309 GLN 1310 0.0089

GLN 1310 MET 1311 0.0080

MET 1311 ALA 1312 0.0028

ALA 1312 PRO 1313 0.0094

PRO 1313 GLN 1314 0.0084

GLN 1314 PRO 1315 0.0030

PRO 1315 GLY 1316 0.0075

GLY 1316 ASP 1317 0.0023

ASP 1317 SER 1318 0.0092

SER 1318 SER 1319 0.0037

SER 1319 ASN 1320 0.0090

ASN 1320 ASN 1321 0.0095

ASN 1321 ASP 1322 0.0092

ASP 1322 LEU 1323 0.0011

LEU 1323 CYS 1324 0.0092

CYS 1324 PHE 1325 0.0232

PHE 1325 LYS 1326 0.0163

LYS 1326 LEU 1327 0.0270

LEU 1327 ASP 1328 0.0044

ASP 1328 TRP 1329 0.0234

TRP 1329 ALA 1330 0.0119

ALA 1330 PRO 1331 0.0215

PRO 1331 ASP 1332 0.0230

ASP 1332 ILE 1333 0.0148

ILE 1333 SER 1334 0.0253

SER 1334 SER 1335 0.0253

SER 1335 VAL 1336 0.0085

VAL 1336 LYS 1337 0.0092

LYS 1337 GLN 1338 0.0089

GLN 1338 GLU 1339 0.0181

GLU 1339 ARG 1340 0.0196

ARG 1340 LEU 1341 0.0561

LEU 1341 LYS 1342 0.0014

LYS 1342 GLU 1343 0.0334

GLU 1343 LYS 1344 0.0215

LYS 1344 PHE 1345 0.0349

PHE 1345 GLY 1346 0.0058

GLY 1346 PHE 1347 0.0166

PHE 1347 PRO 1348 0.0037

PRO 1348 LEU 1349 0.0174

LEU 1349 ASP 1350 0.0318

ASP 1350 PRO 1351 0.0003

PRO 1351 THR 1352 0.0352

THR 1352 GLU 1353 0.0223

GLU 1353 ALA 1354 0.0233

ALA 1354 ASP 1355 0.0162

ASP 1355 ILE 1356 0.0231

ILE 1356 ILE 1357 0.0231

ILE 1357 MET 1358 0.0034

MET 1358 GLY 1359 0.0365

GLY 1359 LEU 1360 0.0160

LEU 1360 ARG 1361 0.0337

ARG 1361 GLN 1362 0.0071

GLN 1362 ALA 1363 0.0326

ALA 1363 CYS 1364 0.0273

CYS 1364 ILE 1365 0.0136

ILE 1365 HIS 1366 0.0292

HIS 1366 PHE 1367 0.0175

PHE 1367 ILE 1368 0.0376

ILE 1368 HIS 1369 0.0012

HIS 1369 ARG 1370 0.0378

ARG 1370 SER 1371 0.0150

SER 1371 LEU 1372 0.0342

LEU 1372 GLN 1373 0.0050

GLN 1373 SER 1374 0.0322

SER 1374 LEU 1375 0.0216

LEU 1375 THR 1376 0.0335

THR 1376 ALA 1377 0.0356

ALA 1377 PRO 1378 0.0225

PRO 1378 ASP 1379 0.0319

ASP 1379 ARG 1380 0.0370

ARG 1380 ASP 1381 0.0310

ASP 1381 GLN 1382 0.0226

GLN 1382 LEU 1383 0.0347

LEU 1383 ASP 1384 0.0018

ASP 1384 TRP 1385 0.0353

TRP 1385 HIS 1386 0.0376

HIS 1386 GLN 1387 0.0101

GLN 1387 LYS 1388 0.0315

LYS 1388 ARG 1389 0.0396

ARG 1389 PHE 1390 0.0331

PHE 1390 TYR 1391 0.0091

TYR 1391 ASP 1392 0.0371

ASP 1392 TRP 1393 0.0355

TRP 1393 MET 1394 0.0191

MET 1394 VAL 1395 0.0212

VAL 1395 LEU 1396 0.0347

LEU 1396 GLN 1397 0.0370

GLN 1397 ILE 1398 0.0047

ILE 1398 GLN 1399 0.0362

GLN 1399 LEU 1400 0.0319

LEU 1400 ALA 1401 0.0262

ALA 1401 GLU 1402 0.0125

GLU 1402 GLU 1403 0.0353

GLU 1403 ASP 1404 0.0371

ASP 1404 ARG 1405 0.0061

ARG 1405 LEU 1406 0.0298

LEU 1406 ALA 1407 0.0295

ALA 1407 PRO 1408 0.0095

PRO 1408 ASN 1409 0.0188

ASN 1409 SER 1410 0.0231

SER 1410 SER 1411 0.0189

SER 1411 ALA 1412 0.0296

ALA 1412 TRP 1413 0.0149

TRP 1413 LEU 1414 0.0349

LEU 1414 GLN 1415 0.0085

GLN 1415 CYS 1416 0.0343

CYS 1416 SER 1417 0.0298

SER 1417 SER 1418 0.0266

SER 1418 SER 1419 0.0375

SER 1419 ASP 1420 0.0338

ASP 1420 GLU 1421 0.0148

GLU 1421 GLN 1422 0.0349

GLN 1422 LYS 1423 0.0379

LYS 1423 LEU 1424 0.0284

LEU 1424 LEU 1425 0.0202

LEU 1425 GLU 1426 0.0377

GLU 1426 ASN 1427 0.0375

ASN 1427 VAL 1428 0.0220

VAL 1428 ARG 1429 0.0280

ARG 1429 ALA 1430 0.0380

ALA 1430 SER 1431 0.0366

SER 1431 SER 1432 0.0085

SER 1432 VAL 1433 0.0197

VAL 1433 ASN 1434 0.0344

ASN 1434 GLY 1435 0.0071

GLY 1435 GLN 1436 0.0319

GLN 1436 MET 1437 0.0301

MET 1437 VAL 1438 0.0149

VAL 1438 VAL 1439 0.0242

VAL 1439 HIS 1440 0.0211

HIS 1440 VAL 1441 0.0363

VAL 1441 GLY 1442 0.0057

GLY 1442 LYS 1443 0.0306

LYS 1443 SER 1444 0.0234

SER 1444 MET 1445 0.0375

MET 1445 LEU 1446 0.0254

LEU 1446 ALA 1447 0.0255

ALA 1447 ILE 1448 0.0139

ILE 1448 LEU 1449 0.0314

LEU 1449 ARG 1450 0.0364

ARG 1450 HIS 1451 0.0033

HIS 1451 GLU 1452 0.0350

GLU 1452 ILE 1453 0.0090

ILE 1453 ALA 1454 0.0108

ALA 1454 PRO 1455 0.0369

PRO 1455 LEU 1456 0.0058

LEU 1456 GLU 1457 0.0375

GLU 1457 LEU 1458 0.0086

LEU 1458 MET 1459 0.0319

MET 1459 LEU 1460 0.0144

LEU 1460 GLN 1461 0.0249

GLN 1461 ASP 1462 0.0373

ASP 1462 LYS 1463 0.0200

LYS 1463 LEU 1464 0.0157

LEU 1464 LEU 1465 0.0269

LEU 1465 TYR 1466 0.0179

TYR 1466 ARG 1467 0.0204

ARG 1467 TYR 1468 0.0316

TYR 1468 TYR 1469 -0.0023

TYR 1469 THR 1470 0.0348

THR 1470 ASP 1471 0.0073

ASP 1471 ALA 1472 0.0220

ALA 1472 ILE 1473 0.0286

ILE 1473 LYS 1474 0.0264

LYS 1474 TRP 1475 0.0080

TRP 1475 ASP 1476 0.0315

ASP 1476 ARG 1477 0.0349

ARG 1477 SER 1478 0.0262

SER 1478 TYR 1479 0.0170

TYR 1479 GLN 1480 0.0354

GLN 1480 GLN 1481 0.0350

GLN 1481 ILE 1482 0.0164

ILE 1482 ASP 1483 0.0294

ASP 1483 GLN 1484 0.0354

GLN 1484 LEU 1485 0.0308

LEU 1485 VAL 1486 0.0185

VAL 1486 LYS 1487 0.0294

LYS 1487 LEU 1488 0.0317

LEU 1488 HIS 1489 0.0265

HIS 1489 ALA 1490 0.0229

ALA 1490 HIS 1491 0.0301

HIS 1491 LYS 1492 0.0300

LYS 1492 CYS 1493 0.0277

CYS 1493 PRO 1494 0.0310

PRO 1494 THR 1495 0.0240

THR 1495 ALA 1496 0.0139

ALA 1496 LYS 1497 0.0326

LYS 1497 ILE 1498 0.0018

ILE 1498 ILE 1499 0.0228

ILE 1499 GLU 1500 0.0039

GLU 1500 ILE 1501 0.0295

ILE 1501 GLY 1502 0.0175

GLY 1502 ALA 1503 0.0328

ALA 1503 GLY 1504 0.0222

GLY 1504 THR 1505 0.0304

THR 1505 GLY 1506 0.0235

GLY 1506 GLY 1507 0.0146

GLY 1507 CYS 1508 0.0258

CYS 1508 THR 1509 0.0066

THR 1509 ARG 1510 0.0315

ARG 1510 ALA 1511 0.0315

ALA 1511 VAL 1512 0.0121

VAL 1512 LEU 1513 0.0205

LEU 1513 ASP 1514 0.0281

ASP 1514 ALA 1515 0.0323

ALA 1515 LEU 1516 0.0050

LEU 1516 SER 1517 0.0096

SER 1517 ASN 1518 0.0315

ASN 1518 GLN 1519 0.0337

GLN 1519 GLY 1520 0.0313

GLY 1520 ILE 1521 0.0169

ILE 1521 ALA 1522 0.0325

ALA 1522 ARG 1523 0.0329

ARG 1523 CYS 1524 0.0333

CYS 1524 ALA 1525 0.0150

ALA 1525 GLN 1526 0.0220

GLN 1526 TYR 1527 0.0012

TYR 1527 ASP 1528 0.0308

ASP 1528 PHE 1529 0.0084

PHE 1529 THR 1530 0.0285

THR 1530 ASP 1531 0.0113

ASP 1531 VAL 1532 0.0310

VAL 1532 SER 1533 0.0511

SER 1533 SER 1534 0.0208

SER 1534 GLY 1535 0.0118

GLY 1535 PHE 1536 0.0327

PHE 1536 PHE 1537 0.0010

PHE 1537 GLU 1538 0.0324

GLU 1538 ALA 1539 0.0151

ALA 1539 ALA 1540 0.0270

ALA 1540 GLN 1541 0.0060

GLN 1541 GLN 1542 0.0273

GLN 1542 LYS 1543 0.0240

LYS 1543 PHE 1544 0.0128

PHE 1544 ALA 1545 0.0145

ALA 1545 ALA 1546 0.0306

ALA 1546 PHE 1547 0.0295

PHE 1547 ASP 1548 0.0261

ASP 1548 ASP 1549 -0.0155

ASP 1549 VAL 1550 0.0267

VAL 1550 ILE 1551 0.0152

ILE 1551 ARG 1552 0.0310

ARG 1552 PHE 1553 0.0153

PHE 1553 GLN 1554 0.0319

GLN 1554 LYS 1555 0.0177

LYS 1555 LEU 1556 0.0303

LEU 1556 ASP 1557 0.0195

ASP 1557 ILE 1558 0.0318

ILE 1558 GLU 1559 0.0279

GLU 1559 LYS 1560 0.0097

LYS 1560 ASP 1561 0.0061

ASP 1561 ILE 1562 0.0259

ILE 1562 GLU 1563 0.0028

GLU 1563 MET 1564 0.0295

MET 1564 GLN 1565 0.0366

GLN 1565 GLY 1566 0.0096

GLY 1566 PHE 1567 0.0305

PHE 1567 GLU 1568 0.0205

GLU 1568 CYS 1569 0.0279

CYS 1569 GLY 1570 0.0327

GLY 1570 SER 1571 0.0297

SER 1571 TYR 1572 0.0128

TYR 1572 ASP 1573 0.0312

ASP 1573 LEU 1574 0.0044

LEU 1574 VAL 1575 0.0200

VAL 1575 ILE 1576 0.0117

ILE 1576 ALA 1577 0.0126

ALA 1577 SER 1578 0.0104

SER 1578 GLN 1579 0.0118

GLN 1579 VAL 1580 0.0234

VAL 1580 LEU 1581 0.0192

LEU 1581 HIS 1582 0.0024

HIS 1582 ALA 1583 0.0325

ALA 1583 THR 1584 0.0236

THR 1584 GLY 1585 0.0316

GLY 1585 LYS 1586 0.0297

LYS 1586 MET 1587 0.0323

MET 1587 GLU 1588 0.0206

GLU 1588 HIS 1589 0.0213

HIS 1589 THR 1590 0.0327

THR 1590 MET 1591 0.0319

MET 1591 ALA 1592 0.0142

ALA 1592 ASN 1593 0.0280

ASN 1593 VAL 1594 0.0318

VAL 1594 ARG 1595 0.0258

ARG 1595 LYS 1596 0.0112

LYS 1596 LEU 1597 0.0364

LEU 1597 LEU 1598 0.0335

LEU 1598 LYS 1599 0.0132

LYS 1599 PRO 1600 0.0327

PRO 1600 GLY 1601 0.0243

GLY 1601 GLY 1602 0.0315

GLY 1602 LYS 1603 0.0056

LYS 1603 LEU 1604 0.0146

LEU 1604 LEU 1605 0.0189

LEU 1605 LEU 1606 0.0093

LEU 1606 VAL 1607 0.0120

VAL 1607 GLU 1608 0.0177

GLU 1608 THR 1609 0.0007

THR 1609 THR 1610 0.0317

THR 1610 ARG 1611 0.0012

ARG 1611 ASP 1612 0.0283

ASP 1612 GLU 1613 0.0425

GLU 1613 MET 1614 0.0225

MET 1614 ASP 1615 0.0335

ASP 1615 LEU 1616 0.0039

LEU 1616 GLN 1617 0.0349

GLN 1617 LEU 1618 0.0240

LEU 1618 VAL 1619 0.0195

VAL 1619 PHE 1620 0.0144

PHE 1620 GLY 1621 0.0284

GLY 1621 LEU 1622 0.0371

LEU 1622 LEU 1623 0.0005

LEU 1623 PRO 1624 0.0306

PRO 1624 GLY 1625 0.0211

GLY 1625 TRP 1626 0.0177

TRP 1626 TRP 1627 0.0358

TRP 1627 LEU 1628 0.0059

LEU 1628 SER 1629 0.0476

SER 1629 SER 1630 0.0368

SER 1630 GLU 1631 0.0353

GLU 1631 GLU 1632 0.0051

GLU 1632 GLU 1633 0.0362

GLU 1633 ARG 1634 0.0342

ARG 1634 GLN 1635 0.0267

GLN 1635 MET 1636 0.0174

MET 1636 SER 1637 0.0228

SER 1637 PRO 1638 0.0017

PRO 1638 SER 1639 0.0366

SER 1639 LEU 1640 0.0345

LEU 1640 SER 1641 0.0312

SER 1641 THR 1642 0.0226

THR 1642 ASN 1643 0.0365

ASN 1643 SER 1644 0.0337

SER 1644 TRP 1645 0.0366

TRP 1645 GLU 1646 0.0321

GLU 1646 LYS 1647 0.0357

LYS 1647 VAL 1648 0.0290

VAL 1648 LEU 1649 0.0196

LEU 1649 LYS 1650 0.0341

LYS 1650 LYS 1651 0.0357

LYS 1651 THR 1652 0.0241

THR 1652 GLY 1653 0.0178

GLY 1653 PHE 1654 0.0303

PHE 1654 ASP 1655 0.0344

ASP 1655 GLY 1656 0.0032

GLY 1656 LEU 1657 0.0284

LEU 1657 ASP 1658 0.0279

ASP 1658 ILE 1659 0.0201

ILE 1659 GLU 1660 0.0063

GLU 1660 LEU 1661 0.0282

LEU 1661 ARG 1662 0.0069

ARG 1662 ASP 1663 0.0325

ASP 1663 CYS 1664 0.0158

CYS 1664 ASP 1665 0.0325

ASP 1665 SER 1666 0.0115

SER 1666 ASP 1667 0.0347

ASP 1667 GLU 1668 0.0193

GLU 1668 PHE 1669 0.0280

PHE 1669 TYR 1670 0.0011

TYR 1670 SER 1671 0.0293

SER 1671 PHE 1672 0.0009

PHE 1672 SER 1673 0.0200

SER 1673 VAL 1674 0.0057

VAL 1674 MET 1675 0.0267

MET 1675 MET 1676 0.0040

MET 1676 ALA 1677 0.0327

ALA 1677 THR 1678 0.0049

THR 1678 ALA 1679 0.0207

ALA 1679 SER 1680 0.0245

SER 1680 SER 1681 0.0028

SER 1681 THR 1682 0.0213

THR 1682 ILE 1683 0.0206

ILE 1683 ALA 1684 0.0089

ALA 1684 SER 1685 0.0251

SER 1685 SER 1686 0.0056

SER 1686 SER 1687 0.0203

SER 1687 MET 1688 0.0223

MET 1688 ALA 1689 0.0243

ALA 1689 PHE 1690 0.0216

PHE 1690 ALA 1691 0.0240

ALA 1691 ILE 1692 0.0193

ILE 1692 VAL 1693 0.0455

VAL 1693 TYR 1694 0.0261

TYR 1694 GLY 1695 0.0186

GLY 1695 GLU 1696 0.0265

GLU 1696 VAL 1697 0.0014

VAL 1697 PRO 1698 0.0214

PRO 1698 LEU 1699 0.0085

LEU 1699 PRO 1700 0.0075

PRO 1700 ASP 1701 0.0268

ASP 1701 GLN 1702 0.0049

GLN 1702 PHE 1703 0.0239

PHE 1703 LEU 1704 0.0123

LEU 1704 ASP 1705 0.0174

ASP 1705 ASP 1706 0.0167

ASP 1706 MET 1707 0.0104

MET 1707 LYS 1708 0.0241

LYS 1708 THR 1709 0.0089

THR 1709 ALA 1710 0.0270

ALA 1710 ILE 1711 0.0050

ILE 1711 SER 1712 0.0267

SER 1712 SER 1713 0.0072

SER 1713 SER 1714 0.0202

SER 1714 ALA 1715 0.0081

ALA 1715 VAL 1716 0.0252

VAL 1716 SER 1717 0.0195

SER 1717 ASP 1718 0.0262

ASP 1718 PRO 1719 0.0191

PRO 1719 VAL 1720 0.0134

VAL 1720 VAL 1721 0.0267

VAL 1721 GLY 1722 0.0098

GLY 1722 HIS 1723 0.0218

HIS 1723 LEU 1724 0.0167

LEU 1724 ASP 1725 0.0270

ASP 1725 SER 1726 0.0253

SER 1726 ILE 1727 0.0216

ILE 1727 ASP 1728 0.0211

ASP 1728 ALA 1729 0.0248

ALA 1729 THR 1730 0.0181

THR 1730 GLY 1731 0.0208

GLY 1731 LYS 1732 0.0065

LYS 1732 PHE 1733 0.0175

PHE 1733 CYS 1734 0.0265

CYS 1734 ILE 1735 0.0130

ILE 1735 PHE 1736 0.0221

PHE 1736 ILE 1737 0.0148

ILE 1737 GLU 1738 0.0226

GLU 1738 ASP 1739 0.0221

ASP 1739 PRO 1740 0.0240

PRO 1740 GLU 1741 0.0271

GLU 1741 THR 1742 0.0037

THR 1742 ASP 1743 0.0213

ASP 1743 ILE 1744 0.0120

ILE 1744 LEU 1745 0.0215

LEU 1745 SER 1746 0.0267

SER 1746 SER 1747 0.0159

SER 1747 PRO 1748 0.0249

PRO 1748 ASP 1749 0.0179

ASP 1749 GLU 1750 0.0113

GLU 1750 LYS 1751 0.0202

LYS 1751 SER 1752 0.0069

SER 1752 TYR 1753 0.0201

TYR 1753 ALA 1754 0.0198

ALA 1754 SER 1755 0.0081

SER 1755 ILE 1756 0.0222

ILE 1756 GLN 1757 -0.0132

GLN 1757 LYS 1758 0.0260

LYS 1758 LEU 1759 0.0012

LEU 1759 VAL 1760 0.0259

VAL 1760 THR 1761 0.0085

THR 1761 ARG 1762 0.0228

ARG 1762 CYS 1763 0.0017

CYS 1763 LYS 1764 0.0235

LYS 1764 GLY 1765 0.0166

GLY 1765 LEU 1766 0.0225

LEU 1766 ILE 1767 0.0076

ILE 1767 TRP 1768 0.0249

TRP 1768 VAL 1769 0.0078

VAL 1769 SER 1770 0.0258

SER 1770 ARG 1771 0.0146

ARG 1771 GLY 1772 0.0259

GLY 1772 GLY 1773 0.0079

GLY 1773 ALA 1774 0.0213

ALA 1774 MET 1775 0.0106

MET 1775 HIS 1776 0.0234

HIS 1776 GLY 1777 0.0064

GLY 1777 THR 1778 0.0183

THR 1778 ARG 1779 0.0092

ARG 1779 PRO 1780 0.0082

PRO 1780 ASN 1781 0.0154

ASN 1781 SER 1782 0.0164

SER 1782 SER 1783 0.0216

SER 1783 LEU 1784 0.0023

LEU 1784 LYS 1785 0.0227

LYS 1785 THR 1786 0.0196

THR 1786 GLY 1787 0.0072

GLY 1787 LEU 1788 0.0170

LEU 1788 LEU 1789 0.0292

LEU 1789 ARG 1790 0.0265

ARG 1790 THR 1791 0.0004

THR 1791 LEU 1792 0.0264

LEU 1792 ARG 1793 0.0191

ARG 1793 LEU 1794 0.0103

LEU 1794 GLU 1795 0.0147

GLU 1795 TYR 1796 0.0208

TYR 1796 THR 1797 0.0200

THR 1797 GLU 1798 0.0255

GLU 1798 LYS 1799 0.0204

LYS 1799 ARG 1800 0.0035

ARG 1800 PHE 1801 0.0265

PHE 1801 ILE 1802 0.0038

ILE 1802 SER 1803 0.0245

SER 1803 LEU 1804 0.0038

LEU 1804 ASP 1805 0.0194

ASP 1805 LEU 1806 0.0079

LEU 1806 ASP 1807 0.0136

ASP 1807 SER 1808 0.0244

SER 1808 ALA 1809 0.0025

ALA 1809 ARG 1810 0.0243

ARG 1810 PRO 1811 0.0258

PRO 1811 GLN 1812 0.0048

GLN 1812 TRP 1813 0.0252

TRP 1813 ASN 1814 0.0068

ASN 1814 HIS 1815 0.0234

HIS 1815 ASP 1816 0.0262

ASP 1816 SER 1817 0.0007

SER 1817 ILE 1818 0.0263

ILE 1818 THR 1819 0.0180

THR 1819 THR 1820 0.0184

THR 1820 ILE 1821 0.0019

ILE 1821 ASN 1822 0.0239

ASN 1822 GLU 1823 0.0236

GLU 1823 VAL 1824 0.0056

VAL 1824 LEU 1825 0.0212

LEU 1825 CYS 1826 0.0179

CYS 1826 GLY 1827 0.0248

GLY 1827 ALA 1828 0.0017

ALA 1828 LEU 1829 0.0260

LEU 1829 ALA 1830 0.0156

ALA 1830 GLN 1831 0.0175

GLN 1831 ASN 1832 0.0226

ASN 1832 ALA 1833 0.0094

ALA 1833 ASP 1834 0.0227

ASP 1834 SER 1835 0.0218

SER 1835 SER 1836 0.0117

SER 1836 ILE 1837 0.0426

ILE 1837 LYS 1838 0.0251

LYS 1838 ASP 1839 0.0220

ASP 1839 SER 1840 0.0166

SER 1840 GLU 1841 0.0202

GLU 1841 PHE 1842 0.0039

PHE 1842 ALA 1843 0.0176

ALA 1843 GLU 1844 0.0066

GLU 1844 GLN 1845 0.0137

GLN 1845 ASP 1846 0.0035

ASP 1846 GLY 1847 0.0246

GLY 1847 GLN 1848 0.0235

GLN 1848 LEU 1849 0.0042

LEU 1849 PHE 1850 0.0204

PHE 1850 VAL 1851 0.0100

VAL 1851 PRO 1852 0.0168

PRO 1852 ARG 1853 -0.0616

ARG 1853 ILE 1854 0.0138

ILE 1854 SER 1855 0.0229

SER 1855 CYS 1856 0.0227

CYS 1856 ASP 1857 0.0260

ASP 1857 ILE 1858 0.0235

ILE 1858 ALA 1859 0.0250

ALA 1859 ARG 1860 0.0043

ARG 1860 ASN 1861 0.0213

ASN 1861 GLU 1862 0.0189

GLU 1862 ASP 1863 0.0240

ASP 1863 LEU 1864 0.0023

LEU 1864 SER 1865 0.0261

SER 1865 SER 1866 0.0192

SER 1866 ASP 1867 0.0084

ASP 1867 SER 1868 0.0264

SER 1868 ASN 1869 0.2055

ASN 1869 SER 1870 0.0092

SER 1870 PRO 1871 0.0090

PRO 1871 ALA 1872 0.0045

ALA 1872 GLN 1873 0.0106

GLN 1873 MET 1874 0.0096

MET 1874 GLU 1875 0.0018

GLU 1875 PRO 1876 0.0049

PRO 1876 PHE 1877 0.0070

PHE 1877 HIS 1878 0.0038

HIS 1878 GLN 1879 0.0104

GLN 1879 PRO 1880 0.0025

PRO 1880 GLY 1881 0.0094

GLY 1881 LYS 1882 0.0041

LYS 1882 LEU 1883 0.0106

LEU 1883 LEU 1884 0.0033

LEU 1884 GLN 1885 -0.0185

GLN 1885 MET 1886 0.0041

MET 1886 GLY 1887 0.0053

GLY 1887 ILE 1888 0.0016

ILE 1888 LYS 1889 0.0036

LYS 1889 THR 1890 0.0058

THR 1890 PRO 1891 0.0063

PRO 1891 GLY 1892 0.0052

GLY 1892 LEU 1893 0.0075

LEU 1893 ILE 1894 0.0043

ILE 1894 ASP 1895 0.0063

ASP 1895 THR 1896 0.0072

THR 1896 LEU 1897 0.0008

LEU 1897 GLN 1898 0.0073

GLN 1898 PHE 1899 0.0026

PHE 1899 SER 1900 0.0078

SER 1900 LYS 1901 -0.0045

LYS 1901 THR 1902 0.0043

THR 1902 ASP 1903 0.0047

ASP 1903 ALA 1904 0.0015

ALA 1904 THR 1905 0.0046

THR 1905 ASP 1906 0.0027

ASP 1906 ASN 1907 0.0048

ASN 1907 LEU 1908 0.0075

LEU 1908 PRO 1909 0.0069

PRO 1909 ASN 1910 0.0005

ASN 1910 ASP 1911 0.0077

ASP 1911 TYR 1912 0.0034

TYR 1912 ILE 1913 0.0077

ILE 1913 GLU 1914 0.0039

GLU 1914 ILE 1915 0.0071

ILE 1915 GLU 1916 0.0050

GLU 1916 PRO 1917 -0.0057

PRO 1917 LYS 1918 0.0071

LYS 1918 ALA 1919 0.0057

ALA 1919 PHE 1920 0.0062

PHE 1920 GLY 1921 0.0069

GLY 1921 LEU 1922 0.0011

LEU 1922 ASN 1923 0.0072

ASN 1923 PHE 1924 0.0035

PHE 1924 ARG 1925 0.0070

ARG 1925 ASP 1926 0.0066

ASP 1926 VAL 1927 0.0016

VAL 1927 MET 1928 0.0071

MET 1928 VAL 1929 0.0069

VAL 1929 ALA 1930 0.0041

ALA 1930 MET 1931 0.0041

MET 1931 GLY 1932 0.0069

GLY 1932 GLN 1933 -0.0158

GLN 1933 LEU 1934 0.0017

LEU 1934 GLU 1935 0.0067

GLU 1935 GLU 1936 0.0032

GLU 1936 SER 1937 0.0059

SER 1937 ILE 1938 0.0019

ILE 1938 MET 1939 0.0066

MET 1939 GLY 1940 0.0031

GLY 1940 PHE 1941 0.0025

PHE 1941 GLU 1942 0.0044

GLU 1942 CYS 1943 0.0061

CYS 1943 ALA 1944 0.0038

ALA 1944 GLY 1945 0.0060

GLY 1945 VAL 1946 0.0031

VAL 1946 VAL 1947 0.0054

VAL 1947 ARG 1948 0.0063

ARG 1948 ARG 1949 0.0148

ARG 1949 VAL 1950 0.0044

VAL 1950 GLY 1951 0.0071

GLY 1951 PRO 1952 0.0012

PRO 1952 SER 1953 0.0068

SER 1953 SER 1954 0.0063

SER 1954 ALA 1955 0.0043

ALA 1955 GLY 1956 0.0034

GLY 1956 HIS 1957 0.0058

HIS 1957 ASN 1958 0.0072

ASN 1958 ILE 1959 0.0011

ILE 1959 LYS 1960 0.0073

LYS 1960 VAL 1961 0.0036

VAL 1961 GLY 1962 0.0066

GLY 1962 ASP 1963 0.0069

ASP 1963 ARG 1964 0.0040

ARG 1964 VAL 1965 0.0028

VAL 1965 CYS 1966 0.0038

CYS 1966 ALA 1967 0.0066

ALA 1967 LEU 1968 0.0054

LEU 1968 LEU 1969 0.0045

LEU 1969 GLY 1970 0.0064

GLY 1970 GLY 1971 0.0016

GLY 1971 GLN 1972 0.0067

GLN 1972 TRP 1973 0.0065

TRP 1973 THR 1974 0.0061

THR 1974 ASN 1975 0.0065

ASN 1975 THR 1976 0.0024

THR 1976 VAL 1977 0.0067

VAL 1977 ARG 1978 0.0047

ARG 1978 VAL 1979 0.0058

VAL 1979 HIS 1980 0.0030

HIS 1980 TRP 1981 0.0027

TRP 1981 HIS 1982 0.0075

HIS 1982 SER 1983 0.0023

SER 1983 VAL 1984 0.0064

VAL 1984 ALA 1985 0.0052

ALA 1985 PRO 1986 0.0063

PRO 1986 ILE 1987 0.0061

ILE 1987 PRO 1988 0.0055

PRO 1988 GLN 1989 0.0075

GLN 1989 ALA 1990 0.0062

ALA 1990 MET 1991 0.0029

MET 1991 ASP 1992 0.0017

ASP 1992 TRP 1993 0.0053

TRP 1993 GLU 1994 0.0035

GLU 1994 THR 1995 0.0046

THR 1995 ALA 1996 0.0059

ALA 1996 ALA 1997 -0.0056

ALA 1997 SER 1998 0.0075

SER 1998 ILE 1999 0.0040

ILE 1999 PRO 2000 0.0082

PRO 2000 ILE 2001 0.0028

ILE 2001 VAL 2002 0.0083

VAL 2002 PHE 2003 0.0007

PHE 2003 VAL 2004 0.0080

VAL 2004 THR 2005 0.0025

THR 2005 ALA 2006 0.0072

ALA 2006 TYR 2007 0.0011

TYR 2007 ILE 2008 0.0075

ILE 2008 SER 2009 0.0048

SER 2009 LEU 2010 0.0055

LEU 2010 VAL 2011 0.0006

VAL 2011 LYS 2012 0.0082

LYS 2012 ILE 2013 0.0069

ILE 2013 ALA 2014 0.0074

ALA 2014 ARG 2015 0.0000

ARG 2015 MET 2016 0.0075

MET 2016 GLN 2017 0.0035

GLN 2017 ALA 2018 0.0066

ALA 2018 GLY 2019 0.0053

GLY 2019 GLU 2020 0.0028

GLU 2020 THR 2021 0.0013

THR 2021 VAL 2022 0.0053

VAL 2022 LEU 2023 0.0006

LEU 2023 ILE 2024 0.0074

ILE 2024 HIS 2025 0.0013

HIS 2025 ALA 2026 0.0069

ALA 2026 ALA 2027 0.0018

ALA 2027 SER 2028 0.0074

SER 2028 GLY 2029 0.0144

GLY 2029 GLY 2030 0.0034

GLY 2030 VAL 2031 0.0072

VAL 2031 GLY 2032 0.0076

GLY 2032 GLN 2033 0.0048

GLN 2033 ALA 2034 0.0040

ALA 2034 ALA 2035 0.0076

ALA 2035 ILE 2036 0.0078

ILE 2036 ILE 2037 0.0027

ILE 2037 LEU 2038 0.0066

LEU 2038 ALA 2039 0.0073

ALA 2039 LYS 2040 0.0060

LYS 2040 HIS 2041 0.0029

HIS 2041 VAL 2042 0.0078

VAL 2042 GLY 2043 0.0076

GLY 2043 ALA 2044 0.0018

ALA 2044 GLU 2045 0.0176

GLU 2045 ILE 2046 0.0025

ILE 2046 PHE 2047 0.0003

PHE 2047 ALA 2048 0.0045

ALA 2048 THR 2049 0.0005

THR 2049 VAL 2050 0.0060

VAL 2050 GLY 2051 0.0009

GLY 2051 THR 2052 0.0079

THR 2052 ASP 2053 0.0062

ASP 2053 GLU 2054 0.0064

GLU 2054 LYS 2055 0.0062

LYS 2055 ARG 2056 0.0071

ARG 2056 ASP 2057 0.0066

ASP 2057 LEU 2058 0.0056

LEU 2058 LEU 2059 0.0061

LEU 2059 ILE 2060 0.0071

ILE 2060 LYS 2061 0.0056

LYS 2061 GLU 2062 0.0061

GLU 2062 TYR 2063 0.0071

TYR 2063 LYS 2064 0.0076

LYS 2064 ILE 2065 0.0051

ILE 2065 PRO 2066 0.0071

PRO 2066 ASP 2067 0.0007

ASP 2067 ASP 2068 0.0075

ASP 2068 HIS 2069 0.0071

HIS 2069 ILE 2070 0.0037

ILE 2070 PHE 2071 0.0013

PHE 2071 SER 2072 0.0023

SER 2072 SER 2073 0.0076

SER 2073 ARG 2074 -0.0001

ARG 2074 ASN 2075 0.0076

ASN 2075 ALA 2076 0.0067

ALA 2076 LEU 2077 0.0075

LEU 2077 PHE 2078 0.0008

PHE 2078 ALA 2079 0.0073

ALA 2079 LYS 2080 0.0070

LYS 2080 SER 2081 0.0056

SER 2081 ILE 2082 0.0023

ILE 2082 ARG 2083 0.0075

ARG 2083 GLN 2084 0.0073

GLN 2084 ARG 2085 0.0031

ARG 2085 THR 2086 0.0051

THR 2086 ASN 2087 0.0073

ASN 2087 GLY 2088 0.0050

GLY 2088 LYS 2089 0.0037

LYS 2089 GLY 2090 0.0061

GLY 2090 VAL 2091 0.0055

VAL 2091 ASP 2092 0.0035

ASP 2092 VAL 2093 0.0062

VAL 2093 VAL 2094 0.0019

VAL 2094 LEU 2095 0.0077

LEU 2095 ASN 2096 0.0002

ASN 2096 CYS 2097 0.0050

CYS 2097 LEU 2098 0.0021

LEU 2098 ALA 2099 0.0036

ALA 2099 GLY 2100 0.0043

GLY 2100 GLY 2101 0.0075

GLY 2101 LEU 2102 0.0034

LEU 2102 LEU 2103 0.0047

LEU 2103 GLN 2104 0.0071

GLN 2104 GLU 2105 0.0075

GLU 2105 SER 2106 0.0018

SER 2106 PHE 2107 0.0075

PHE 2107 ASP 2108 0.0072

ASP 2108 CYS 2109 0.0033

CYS 2109 LEU 2110 0.0038

LEU 2110 ALA 2111 0.0041

ALA 2111 ASP 2112 0.0074

ASP 2112 PHE 2113 0.0056

PHE 2113 GLY 2114 0.0070

GLY 2114 ARG 2115 0.0081

ARG 2115 PHE 2116 0.0025

PHE 2116 ILE 2117 0.0079

ILE 2117 GLU 2118 0.0023

GLU 2118 ILE 2119 0.0081

ILE 2119 GLY 2120 0.0005

GLY 2120 LYS 2121 0.0064

LYS 2121 ARG 2122 0.0006

ARG 2122 ASP 2123 0.0077

ASP 2123 ILE 2124 0.0053

ILE 2124 GLU 2125 0.0092

GLU 2125 LEU 2126 0.0022

LEU 2126 ASN 2127 0.0065

ASN 2127 HIS 2128 0.0069

HIS 2128 CYS 2129 0.0073

CYS 2129 LEU 2130 0.0030

LEU 2130 ASN 2131 0.0072

ASN 2131 MET 2132 0.0048

MET 2132 GLY 2133 0.0075

GLY 2133 MET 2134 0.0025

MET 2134 PHE 2135 0.0053

PHE 2135 ALA 2136 0.0072

ALA 2136 ARG 2137 0.0041

ARG 2137 SER 2138 0.0045

SER 2138 ALA 2139 0.0069

ALA 2139 THR 2140 0.0070

THR 2140 PHE 2141 -0.0031

PHE 2141 THR 2142 0.0072

THR 2142 ALA 2143 0.0061

ALA 2143 VAL 2144 0.0056

VAL 2144 ASP 2145 0.0075

ASP 2145 LEU 2146 0.0050

LEU 2146 ILE 2147 0.0069

ILE 2147 ALA 2148 0.0078

ALA 2148 ILE 2149 0.0017

ILE 2149 GLY 2150 0.0081

GLY 2150 ARG 2151 0.0076

ARG 2151 ASP 2152 0.0067

ASP 2152 ARG 2153 0.0045

ARG 2153 SER 2154 0.0076

SER 2154 TYR 2155 0.0014

TYR 2155 MET 2156 0.0068

MET 2156 PHE 2157 0.0080

PHE 2157 ALA 2158 0.0012

ALA 2158 GLU 2159 0.0065

GLU 2159 ALA 2160 0.0038

ALA 2160 LEU 2161 0.0074

LEU 2161 PRO 2162 0.0007

PRO 2162 LYS 2163 0.0072

LYS 2163 ILE 2164 0.0027

ILE 2164 MET 2165 0.0066

MET 2165 THR 2166 0.0013

THR 2166 LEU 2167 0.0063

LEU 2167 LEU 2168 0.0051

LEU 2168 GLN 2169 0.0027

GLN 2169 GLU 2170 0.0054

GLU 2170 LYS 2171 0.0029

LYS 2171 ALA 2172 0.0076

ALA 2172 ILE 2173 -0.0101

ILE 2173 ARG 2174 0.0042

ARG 2174 PRO 2175 0.0030

PRO 2175 VAL 2176 0.0011

VAL 2176 THR 2177 0.0053

THR 2177 PRO 2178 0.0030

PRO 2178 ILE 2179 0.0081

ILE 2179 SER 2180 0.0013

SER 2180 ILE 2181 0.0082

ILE 2181 TYR 2182 0.0036

TYR 2182 LYS 2183 0.0079

LYS 2183 ILE 2184 0.0078

ILE 2184 GLY 2185 0.0024

GLY 2185 ASP 2186 0.0074

ASP 2186 ILE 2187 0.0076

ILE 2187 GLU 2188 0.0010

GLU 2188 THR 2189 -0.0016

THR 2189 ALA 2190 0.0020

ALA 2190 PHE 2191 0.0069

PHE 2191 ARG 2192 0.0026

ARG 2192 LEU 2193 0.0056

LEU 2193 MET 2194 0.0058

MET 2194 GLN 2195 0.0026

GLN 2195 ALA 2196 0.0068

ALA 2196 GLY 2197 0.0022

GLY 2197 LYS 2198 0.0080

LYS 2198 HIS 2199 0.0013

HIS 2199 MET 2200 0.0025

MET 2200 GLY 2201 0.0014

GLY 2201 LYS 2202 0.0080

LYS 2202 ILE 2203 0.0054

ILE 2203 VAL 2204 0.0060

VAL 2204 ILE 2205 0.0069

ILE 2205 THR 2206 0.0056

THR 2206 ALA 2207 0.0060

ALA 2207 PRO 2208 0.0060

PRO 2208 GLU 2209 0.0060

GLU 2209 ASP 2210 0.0000

ASP 2210 ALA 2211 0.0060

ALA 2211 MET 2212 0.0033

MET 2212 VAL 2213 0.0061

VAL 2213 PRO 2214 0.0040

PRO 2214 VAL 2215 0.0042

VAL 2215 ILE 2216 0.0060

ILE 2216 THR 2217 0.0050

THR 2217 ARG 2218 0.0054

ARG 2218 PRO 2219 0.0061

PRO 2219 PRO 2220 0.0012

PRO 2220 LYS 2221 -0.0102

LYS 2221 LEU 2222 0.0201

LEU 2222 GLN 2223 0.0227

GLN 2223 LEU 2224 0.0190

LEU 2224 ARG 2225 0.0235

ARG 2225 PRO 2226 0.0054

PRO 2226 ASP 2227 0.0226

ASP 2227 ALA 2228 0.0233

ALA 2228 SER 2229 0.0159

SER 2229 TYR 2230 0.0230

TYR 2230 LEU 2231 0.0215

LEU 2231 ILE 2232 0.0204

ILE 2232 VAL 2233 0.0226

VAL 2233 GLY 2234 0.0118

GLY 2234 GLY 2235 0.0227

GLY 2235 LEU 2236 0.0029

LEU 2236 GLY 2237 -0.0279

GLY 2237 GLY 2238 0.0189

GLY 2238 ILE 2239 0.0019

ILE 2239 GLY 2240 0.0186

GLY 2240 ARG 2241 0.0098

ARG 2241 SER 2242 0.0112

SER 2242 LEU 2243 0.0111

LEU 2243 CYS 2244 0.0101

CYS 2244 LYS 2245 0.0185

LYS 2245 ASN 2246 0.0016

ASN 2246 PHE 2247 0.0186

PHE 2247 VAL 2248 0.0085

VAL 2248 GLU 2249 0.0183

GLU 2249 ASN 2250 0.0023

ASN 2250 GLY 2251 0.0181

GLY 2251 ALA 2252 0.0176

ALA 2252 ARG 2253 -0.0020

ARG 2253 SER 2254 0.0221

SER 2254 LEU 2255 0.0219

LEU 2255 VAL 2256 0.0221

VAL 2256 LEU 2257 0.0184

LEU 2257 LEU 2258 0.0219

LEU 2258 SER 2259 0.0143

SER 2259 ARG 2260 0.0197

ARG 2260 ASN 2261 0.0026

ASN 2261 ALA 2262 0.0221

ALA 2262 ASN 2263 0.0007

ASN 2263 VAL 2264 0.0212

VAL 2264 SER 2265 0.0219

SER 2265 GLN 2266 0.0084

GLN 2266 GLN 2267 0.0160

GLN 2267 SER 2268 0.0097

SER 2268 GLY 2269 0.0255

GLY 2269 GLU 2270 0.0222

GLU 2270 PHE 2271 0.0000

PHE 2271 LEU 2272 0.0219

LEU 2272 ASP 2273 0.0133

ASP 2273 GLU 2274 0.0166

GLU 2274 LEU 2275 0.0064

LEU 2275 ARG 2276 0.0180

ARG 2276 SER 2277 0.0191

SER 2277 THR 2278 0.0029

THR 2278 GLY 2279 0.0223

GLY 2279 CYS 2280 0.0155

CYS 2280 ILE 2281 0.0221

ILE 2281 VAL 2282 0.0220

VAL 2282 GLY 2283 0.0221

GLY 2283 VAL 2284 0.0203

VAL 2284 VAL 2285 0.1116

VAL 2285 ASP 2286 0.0203

ASP 2286 CYS 2287 0.0043

CYS 2287 ASP 2288 0.0180

ASP 2288 ILE 2289 0.0016

ILE 2289 SER 2290 0.0195

SER 2290 SER 2291 0.0191

SER 2291 LYS 2292 0.0110

LYS 2292 THR 2293 0.0114

THR 2293 GLN 2294 0.0136

GLN 2294 VAL 2295 0.0089

VAL 2295 GLU 2296 0.0191

GLU 2296 ALA 2297 0.0027

ALA 2297 THR 2298 0.0208

THR 2298 MET 2299 0.0060

MET 2299 LEU 2300 0.0195

LEU 2300 ARG 2301 0.0132

ARG 2301 LEU 2302 0.0166

LEU 2302 LYS 2303 0.0111

LYS 2303 LYS 2304 0.0078

LYS 2304 ASP 2305 0.0118

ASP 2305 MET 2306 0.0129

MET 2306 LEU 2307 0.0071

LEU 2307 PRO 2308 0.0043

PRO 2308 ILE 2309 0.0192

ILE 2309 ARG 2310 0.0089

ARG 2310 GLY 2311 0.0193

GLY 2311 ILE 2312 0.0169

ILE 2312 VAL 2313 0.0183

VAL 2313 HIS 2314 0.0188

HIS 2314 ALA 2315 0.0127

ALA 2315 GLY 2316 0.0158

GLY 2316 MET 2317 0.0586

MET 2317 VAL 2318 0.0126

VAL 2318 LEU 2319 0.0218

LEU 2319 GLN 2320 0.0199

GLN 2320 ASP 2321 0.0221

ASP 2321 SER 2322 0.0225

SER 2322 VAL 2323 0.0160

VAL 2323 PHE 2324 0.0117

PHE 2324 GLU 2325 0.0193

GLU 2325 ARG 2326 0.0055

ARG 2326 MET 2327 0.0199

MET 2327 SER 2328 0.0211

SER 2328 LEU 2329 0.0134

LEU 2329 ASP 2330 0.0135

ASP 2330 ASP 2331 0.0225

ASP 2331 TYR 2332 0.0001

TYR 2332 ASN 2333 0.0421

ASN 2333 THR 2334 0.0085

THR 2334 ALA 2335 0.0152

ALA 2335 ILE 2336 0.0024

ILE 2336 ARG 2337 0.0186

ARG 2337 PRO 2338 0.0193

PRO 2338 LYS 2339 0.0068

LYS 2339 VAL 2340 0.0129

VAL 2340 GLN 2341 0.0182

GLN 2341 GLY 2342 0.0159

GLY 2342 SER 2343 0.0072

SER 2343 TRP 2344 0.0130

TRP 2344 ASN 2345 0.0129

ASN 2345 LEU 2346 0.0194

LEU 2346 HIS 2347 0.0006

HIS 2347 SER 2348 0.0192

SER 2348 GLY 2349 0.0229

GLY 2349 LEU 2350 0.0153

LEU 2350 SER 2351 0.0034

SER 2351 ASP 2352 0.0192

ASP 2352 CYS 2353 0.0180

CYS 2353 ASP 2354 0.0110

ASP 2354 LEU 2355 0.0169

LEU 2355 ASP 2356 0.0184

ASP 2356 PHE 2357 0.0177

PHE 2357 PHE 2358 0.0171

PHE 2358 ILE 2359 0.0167

ILE 2359 MET 2360 0.0168

MET 2360 LEU 2361 0.0136

LEU 2361 SER 2362 0.0173

SER 2362 SER 2363 0.0184

SER 2363 LEU 2364 0.0151

LEU 2364 ALA 2365 0.0109

ALA 2365 GLY 2366 0.0113

GLY 2366 VAL 2367 0.0122

VAL 2367 SER 2368 0.0175

SER 2368 GLY 2369 0.0165

GLY 2369 SER 2370 0.0004

SER 2370 ALA 2371 0.0166

ALA 2371 SER 2372 0.0140

SER 2372 GLN 2373 0.0177

GLN 2373 ALA 2374 0.0117

ALA 2374 ASN 2375 0.0216

ASN 2375 TYR 2376 0.0228

TYR 2376 THR 2377 0.0071

THR 2377 ALA 2378 0.0183

ALA 2378 GLY 2379 0.0210

GLY 2379 GLY 2380 0.0194

GLY 2380 ALA 2381 0.0001

ALA 2381 TYR 2382 0.0217

TYR 2382 GLN 2383 0.0214

GLN 2383 ASP 2384 0.0097

ASP 2384 ALA 2385 0.0141

ALA 2385 LEU 2386 0.0196

LEU 2386 ALA 2387 0.0207

ALA 2387 LYS 2388 0.0033

LYS 2388 TYR 2389 0.0217

TYR 2389 ARG 2390 0.0204

ARG 2390 ARG 2391 0.0125

ARG 2391 ALA 2392 0.0105

ALA 2392 GLN 2393 0.0208

GLN 2393 GLY 2394 0.0217

GLY 2394 LEU 2395 0.0006

LEU 2395 SER 2396 0.0149

SER 2396 ALA 2397 -0.0052

ALA 2397 VAL 2398 0.0177

VAL 2398 SER 2399 0.0142

SER 2399 ILE 2400 0.0151

ILE 2400 ASP 2401 0.0175

ASP 2401 LEU 2402 0.0076

LEU 2402 GLY 2403 0.0174

GLY 2403 MET 2404 0.0028

MET 2404 VAL 2405 0.0158

VAL 2405 GLN 2406 0.0122

GLN 2406 SER 2407 0.0129

SER 2407 VAL 2408 0.0182

VAL 2408 GLY 2409 0.0183

GLY 2409 TYR 2410 0.0174

TYR 2410 VAL 2411 0.0171

VAL 2411 ALA 2412 0.0136

ALA 2412 GLU 2413 0.0218

GLU 2413 THR 2414 0.0200

THR 2414 LYS 2415 0.0190

LYS 2415 GLY 2416 0.0130

GLY 2416 VAL 2417 0.0085

VAL 2417 ALA 2418 0.0135

ALA 2418 GLU 2419 0.0200

GLU 2419 ARG 2420 0.0191

ARG 2420 LEU 2421 0.0073

LEU 2421 VAL 2422 0.0174

VAL 2422 ARG 2423 0.0200

ARG 2423 MET 2424 0.0149

MET 2424 GLY 2425 0.0092

GLY 2425 TYR 2426 0.0190

TYR 2426 SER 2427 0.0199

SER 2427 PRO 2428 0.0106

PRO 2428 ILE 2429 0.0365

ILE 2429 SER 2430 0.0106

SER 2430 GLU 2431 0.0145

GLU 2431 MET 2432 0.0103

MET 2432 GLU 2433 0.0057

GLU 2433 VAL 2434 0.0156

VAL 2434 LEU 2435 0.0162

LEU 2435 LYS 2436 0.0044

LYS 2436 ILE 2437 0.0130

ILE 2437 VAL 2438 0.0140

VAL 2438 GLU 2439 0.0156

GLU 2439 HIS 2440 0.0022

HIS 2440 ALA 2441 0.0164

ALA 2441 ILE 2442 0.0156

ILE 2442 THR 2443 0.0106

THR 2443 ASN 2444 0.0065

ASN 2444 PRO 2445 0.0401

PRO 2445 PRO 2446 0.0156

PRO 2446 PRO 2447 0.0032

PRO 2447 GLU 2448 0.0206

GLU 2448 ALA 2449 0.0143

ALA 2449 SER 2450 0.0210

SER 2450 SER 2451 0.0173

SER 2451 ALA 2452 0.0101

ALA 2452 GLN 2453 0.0120

GLN 2453 ILE 2454 0.0172

ILE 2454 ILE 2455 0.0161

ILE 2455 THR 2456 0.0105

THR 2456 GLY 2457 0.0107

GLY 2457 ILE 2458 0.0165

ILE 2458 SER 2459 0.0206

SER 2459 THR 2460 0.0066

THR 2460 LYS 2461 0.0589

LYS 2461 PRO 2462 0.0229

PRO 2462 GLY 2463 0.0058

GLY 2463 ARG 2464 0.0170

ARG 2464 HIS 2465 0.0229

HIS 2465 TRP 2466 0.0032

TRP 2466 THR 2467 0.0200

THR 2467 GLU 2468 0.0056

GLU 2468 SER 2469 0.0212

SER 2469 SER 2470 0.0210

SER 2470 TRP 2471 0.0171

TRP 2471 LEU 2472 0.0163

LEU 2472 GLN 2473 0.0203

GLN 2473 ASP 2474 0.0181

ASP 2474 ALA 2475 -0.0000

ALA 2475 ARG 2476 0.0233

ARG 2476 PHE 2477 0.0138

PHE 2477 ALA 2478 0.0172

ALA 2478 THR 2479 0.0164

THR 2479 LEU 2480 0.0081

LEU 2480 ARG 2481 0.0202

ARG 2481 GLU 2482 0.0095

GLU 2482 ARG 2483 0.0237

ARG 2483 ALA 2484 0.0023

ALA 2484 ARG 2485 0.0217

ARG 2485 ASP 2486 0.0109

ASP 2486 VAL 2487 0.0132

VAL 2487 LYS 2488 0.0171

LYS 2488 GLU 2489 0.0107

GLU 2489 LEU 2490 0.0209

LEU 2490 SER 2491 0.0047

SER 2491 ASN 2492 0.0233

ASN 2492 SER 2493 -0.0176

SER 2493 GLN 2494 0.0234

GLN 2494 ASN 989 -0.1706

ASN 989 LYS 990 0.0052

LYS 990 ALA 991 0.0014

ALA 991 HIS 992 0.0043

HIS 992 ARG 993 0.0035

ARG 993 GLN 994 0.0025

GLN 994 ARG 995 0.0037

ARG 995 VAL 996 0.0045

VAL 996 HIS 997 0.0047

HIS 997 PRO 998 0.0040

PRO 998 PRO 999 0.0051

PRO 999 HIS 1000 0.0015

HIS 1000 ASP 1001 0.0054

ASP 1001 LEU 1002 0.0007

LEU 1002 LEU 1003 0.0056

LEU 1003 GLY 1004 0.0005

GLY 1004 SER 1005 -0.0280

SER 1005 LEU 1006 0.0046

LEU 1006 ILE 1007 0.0050

ILE 1007 VAL 1008 0.0039

VAL 1008 GLY 1009 0.0051

GLY 1009 ARG 1010 0.0001

ARG 1010 ASP 1011 0.0030

ASP 1011 LEU 1012 0.0051

LEU 1012 ARG 1013 0.0005

ARG 1013 GLU 1014 0.0054

GLU 1014 PRO 1015 0.0030

PRO 1015 THR 1016 0.0047

THR 1016 TRP 1017 0.0043

TRP 1017 ARG 1018 0.0037

ARG 1018 HIS 1019 0.0053

HIS 1019 PHE 1020 0.0036

PHE 1020 ILE 1021 -0.1602

ILE 1021 ARG 1022 0.0011

ARG 1022 VAL 1023 0.0019

VAL 1023 GLN 1024 0.0003

GLN 1024 ASP 1025 0.0020

ASP 1025 ILE 1026 0.0004

ILE 1026 PRO 1027 0.0018

PRO 1027 TRP 1028 0.0007

TRP 1028 ILE 1029 0.0017

ILE 1029 ARG 1030 0.0018

ARG 1030 ASP 1031 0.0011

ASP 1031 HIS 1032 0.0007

HIS 1032 VAL 1033 0.0019

VAL 1033 VAL 1034 0.0006

VAL 1034 GLN 1035 0.0020

GLN 1035 SER 1036 -0.0001

SER 1036 ALA 1037 -0.0915

ALA 1037 LEU 1038 0.0037

LEU 1038 VAL 1039 0.0014

VAL 1039 TYR 1040 0.0037

TYR 1040 PRO 1041 0.0007

PRO 1041 GLY 1042 0.0016

GLY 1042 ALA 1043 0.0036

ALA 1043 GLY 1044 0.0009

GLY 1044 PHE 1045 0.0036

PHE 1045 ILE 1046 0.0017

ILE 1046 CYS 1047 0.0022

CYS 1047 MET 1048 0.0023

MET 1048 ALA 1049 0.0014

ALA 1049 MET 1050 0.0035

MET 1050 GLU 1051 0.0003

GLU 1051 ALA 1052 0.0038

ALA 1052 MET 1053 -0.0361

MET 1053 VAL 1054 0.0047

VAL 1054 GLN 1055 0.0013

GLN 1055 LEU 1056 0.0044

LEU 1056 HIS 1057 0.0046

HIS 1057 GLU 1058 0.0016

GLU 1058 LEU 1059 0.0046

LEU 1059 ARG 1060 0.0029

ARG 1060 ASP 1061 0.0046

ASP 1061 SER 1062 0.0041

SER 1062 GLN 1063 0.0011

GLN 1063 SER 1064 0.0056

SER 1064 ARG 1065 0.0009

ARG 1065 LYS 1066 0.0054

LYS 1066 VAL 1067 0.0057

VAL 1067 ALA 1068 0.0010

ALA 1068 GLY 1069 -0.0116

GLY 1069 TYR 1070 0.0043

TYR 1070 ARG 1071 0.0020

ARG 1071 LEU 1072 0.0042

LEU 1072 ALA 1073 0.0027

ALA 1073 GLU 1074 0.0043

GLU 1074 VAL 1075 0.0014

VAL 1075 ASP 1076 0.0042

ASP 1076 ILE 1077 0.0019

ILE 1077 LEU 1078 0.0039

LEU 1078 ARG 1079 0.0013

ARG 1079 ALA 1080 0.0031

ALA 1080 MET 1081 0.0009

MET 1081 LEU 1082 0.0022

LEU 1082 ILE 1083 0.0015

ILE 1083 PRO 1084 0.0011

PRO 1084 ASP 1085 0.0494

ASP 1085 THR 1086 0.0016

THR 1086 SER 1087 0.0024

SER 1087 GLU 1088 0.0041

GLU 1088 GLY 1089 0.0003

GLY 1089 LEU 1090 0.0020

LEU 1090 GLU 1091 0.0048

GLU 1091 ALA 1092 0.0013

ALA 1092 HIS 1093 0.0040

HIS 1093 ILE 1094 0.0022

ILE 1094 SER 1095 0.0043

SER 1095 LEU 1096 0.0028

LEU 1096 ARG 1097 0.0037

ARG 1097 PRO 1098 0.0029

PRO 1098 CYS 1099 0.0006

CYS 1099 SER 1100 0.0044

SER 1100 THR 1101 0.0127

THR 1101 LYS 1102 0.0022

LYS 1102 LEU 1103 0.0048

LEU 1103 LEU 1104 0.0027

LEU 1104 LEU 1105 0.0033

LEU 1105 THR 1106 0.0050

THR 1106 ASN 1107 0.0009

ASN 1107 GLU 1108 0.0012

GLU 1108 TRP 1109 0.0049

TRP 1109 TYR 1110 0.0025

TYR 1110 ASP 1111 0.0049

ASP 1111 PHE 1112 0.0028

PHE 1112 CYS 1113 0.0046

CYS 1113 VAL 1114 0.0033

VAL 1114 SER 1115 0.0040

SER 1115 SER 1116 0.0020

SER 1116 VAL 1117 0.0020

VAL 1117 GLY 1118 0.0050

GLY 1118 ASP 1119 0.0019

ASP 1119 ASP 1120 0.0043

ASP 1120 ASP 1121 0.0052

ASP 1121 LYS 1122 0.0001

LYS 1122 PHE 1123 0.0039

PHE 1123 VAL 1124 0.0030

VAL 1124 ASP 1125 0.0027

ASP 1125 HIS 1126 0.0051

HIS 1126 CYS 1127 0.0034

CYS 1127 ARG 1128 0.0038

ARG 1128 GLY 1129 0.0036

GLY 1129 ARG 1130 0.0052

ARG 1130 ILE 1131 0.0044

ILE 1131 THR 1132 0.0052

THR 1132 ILE 1133 0.0149

ILE 1133 GLU 1134 0.0013

GLU 1134 PHE 1135 0.0072

PHE 1135 ASP 1136 0.0043

ASP 1136 THR 1137 0.0040

THR 1137 SER 1138 0.0057

SER 1138 GLY 1139 0.0009

GLY 1139 SER 1140 0.0067

SER 1140 ALA 1141 0.0048

ALA 1141 ASP 1142 0.0067

ASP 1142 THR 1143 0.0063

THR 1143 PRO 1144 0.0064

PRO 1144 ARG 1145 0.0041

ARG 1145 THR 1146 0.0040

THR 1146 SER 1147 0.0068

SER 1147 LEU 1148 0.0063

LEU 1148 ARG 1149 0.0730

ARG 1149 GLU 1150 0.0096

GLU 1150 ARG 1151 0.0051

ARG 1151 SER 1152 0.0102

SER 1152 ARG 1153 0.0074

ARG 1153 SER 1154 0.0093

SER 1154 THR 1155 0.0129

THR 1155 GLY 1156 0.0002

GLY 1156 LEU 1157 0.0067

LEU 1157 MET 1158 0.0098

MET 1158 ARG 1159 0.0005

ARG 1159 SER 1160 0.0110

SER 1160 VAL 1161 0.0034

VAL 1161 ASP 1162 0.0074

ASP 1162 PRO 1163 0.0133

PRO 1163 SER 1164 0.0006

SER 1164 ASN 1165 0.0740

ASN 1165 LEU 1166 0.0009

LEU 1166 TYR 1167 0.0004

TYR 1167 SER 1168 0.0008

SER 1168 PHE 1169 0.0009

PHE 1169 LEU 1170 0.0011

LEU 1170 ARG 1171 0.0001

ARG 1171 ALA 1172 0.0010

ALA 1172 GLN 1173 0.0010

GLN 1173 GLY 1174 0.0010

GLY 1174 ILE 1175 0.0005

ILE 1175 TYR 1176 0.0008

TYR 1176 HIS 1177 0.0007

HIS 1177 GLY 1178 0.0007

GLY 1178 PRO 1179 0.0010

PRO 1179 ILE 1180 0.0010

ILE 1180 PHE 1181 0.0183

PHE 1181 GLN 1182 0.0037

GLN 1182 ASN 1183 0.0014

ASN 1183 LEU 1184 0.0023

LEU 1184 LYS 1185 0.0034

LYS 1185 THR 1186 0.0020

THR 1186 ILE 1187 0.0039

ILE 1187 SER 1188 0.0010

SER 1188 SER 1189 0.0042

SER 1189 ARG 1190 0.0027

ARG 1190 LYS 1191 0.0041

LYS 1191 ASP 1192 0.0037

ASP 1192 HIS 1193 0.0040

HIS 1193 SER 1194 0.0030

SER 1194 GLU 1195 0.0041

GLU 1195 SER 1196 0.0008

SER 1196 SER 1197 -0.0278

SER 1197 PHE 1198 0.0005

PHE 1198 VAL 1199 0.0019

VAL 1199 VAL 1200 0.0026

VAL 1200 ALA 1201 0.0007

ALA 1201 ASN 1202 0.0012

ASN 1202 THR 1203 0.0030

THR 1203 ALA 1204 0.0022

ALA 1204 SER 1205 0.0032

SER 1205 VAL 1206 0.0030

VAL 1206 MET 1207 0.0036

MET 1207 PRO 1208 0.0003

PRO 1208 ASN 1209 0.0036

ASN 1209 GLY 1210 0.0002

GLY 1210 PHE 1211 0.0038

PHE 1211 GLN 1212 0.0013

GLN 1212 SER 1213 0.0135

SER 1213 PRO 1214 0.0006

PRO 1214 HIS 1215 0.0017

HIS 1215 VAL 1216 -0.0000

VAL 1216 ILE 1217 0.0032

ILE 1217 HIS 1218 0.0013

HIS 1218 PRO 1219 0.0033

PRO 1219 THR 1220 0.0034

THR 1220 THR 1221 0.0013

THR 1221 LEU 1222 0.0023

LEU 1222 ASP 1223 0.0028

ASP 1223 SER 1224 0.0032

SER 1224 ILE 1225 0.0005

ILE 1225 PHE 1226 0.0032

PHE 1226 GLN 1227 0.0030

GLN 1227 GLY 1228 0.0012

GLY 1228 ALA 1229 -0.0262

ALA 1229 TYR 1230 0.0012

TYR 1230 THR 1231 0.0012

THR 1231 ALA 1232 0.0015

ALA 1232 LEU 1233 0.0012

LEU 1233 PRO 1234 0.0022

PRO 1234 GLY 1235 0.0019

GLY 1235 ALA 1236 0.0022

ALA 1236 GLY 1237 0.0007

GLY 1237 LEU 1238 0.0011

LEU 1238 ASP 1239 0.0022

ASP 1239 GLN 1240 0.0020

GLN 1240 ASN 1241 0.0007

ASN 1241 THR 1242 0.0019

THR 1242 ALA 1243 0.0022

ALA 1243 MET 1244 0.0009

MET 1244 ILE 1245 -0.0895

ILE 1245 PRO 1246 0.0024

PRO 1246 ARG 1247 0.0032

ARG 1247 SER 1248 0.0019

SER 1248 ILE 1249 0.0023

ILE 1249 GLN 1250 0.0009

GLN 1250 GLU 1251 0.0034

GLU 1251 LEU 1252 0.0022

LEU 1252 TYR 1253 0.0033

TYR 1253 LEU 1254 0.0020

LEU 1254 SER 1255 0.0030

SER 1255 SER 1256 0.0019

SER 1256 ALA 1257 0.0031

ALA 1257 LEU 1258 0.0025

LEU 1258 THR 1259 0.0012

THR 1259 SER 1260 0.0010

SER 1260 ASP 1261 0.0231

ASP 1261 VAL 1262 0.0015

VAL 1262 GLY 1263 0.0025

GLY 1263 GLN 1264 0.0004

GLN 1264 CYS 1265 0.0025

CYS 1265 LEU 1266 0.0025

LEU 1266 VAL 1267 0.0022

VAL 1267 SER 1268 0.0028

SER 1268 ASP 1269 0.0016

ASP 1269 THR 1270 0.0021

THR 1270 SER 1271 0.0020

SER 1271 LEU 1272 0.0021

LEU 1272 ILE 1273 0.0026

ILE 1273 ARG 1274 0.0014

ARG 1274 TYR 1275 0.0009

TYR 1275 ASP 1276 0.0018

ASP 1276 GLY 1277 -0.0177

GLY 1277 GLN 1278 0.0022

GLN 1278 SER 1279 0.0017

SER 1279 PHE 1280 0.0011

PHE 1280 THR 1281 0.0015

THR 1281 VAL 1282 0.0023

VAL 1282 ASN 1283 0.0016

ASN 1283 VAL 1284 0.0027

VAL 1284 ASP 1285 0.0020

ASP 1285 VAL 1286 0.0023

VAL 1286 SER 1287 0.0024

SER 1287 SER 1288 0.0025

SER 1288 LYS 1289 0.0025

LYS 1289 ALA 1290 0.0026

ALA 1290 ASP 1291 0.0012

ASP 1291 SER 1292 0.0010

SER 1292 GLU 1293 0.0205

GLU 1293 HIS 1294 0.0009

HIS 1294 THR 1295 0.0029

THR 1295 PRO 1296 0.0013

PRO 1296 VAL 1297 0.0015

VAL 1297 LEU 1298 0.0022

LEU 1298 GLU 1299 0.0027

GLU 1299 ILE 1300 0.0018

ILE 1300 LYS 1301 0.0023

LYS 1301 GLY 1302 0.0023

GLY 1302 LEU 1303 0.0007

LEU 1303 ARG 1304 0.0020

ARG 1304 ASN 1305 0.0009

ASN 1305 GLN 1306 0.0017

GLN 1306 SER 1307 0.0013

SER 1307 VAL 1308 0.0004

VAL 1308 GLY 1309 -0.2441

GLY 1309 GLN 1310 0.0082

GLN 1310 MET 1311 0.0076

MET 1311 ALA 1312 0.0025

ALA 1312 PRO 1313 0.0087

PRO 1313 GLN 1314 0.0080

GLN 1314 PRO 1315 0.0029

PRO 1315 GLY 1316 0.0072

GLY 1316 ASP 1317 0.0020

ASP 1317 SER 1318 0.0083

SER 1318 SER 1319 0.0040

SER 1319 ASN 1320 0.0082

ASN 1320 ASN 1321 0.0086

ASN 1321 ASP 1322 0.0087

ASP 1322 LEU 1323 0.0013

LEU 1323 CYS 1324 0.0083

CYS 1324 PHE 1325 0.0242

PHE 1325 LYS 1326 0.0154

LYS 1326 LEU 1327 0.0270

LEU 1327 ASP 1328 0.0038

ASP 1328 TRP 1329 0.0226

TRP 1329 ALA 1330 0.0110

ALA 1330 PRO 1331 0.0205

PRO 1331 ASP 1332 0.0249

ASP 1332 ILE 1333 0.0147

ILE 1333 SER 1334 0.0270

SER 1334 SER 1335 0.0259

SER 1335 VAL 1336 0.0106

VAL 1336 LYS 1337 0.0076

LYS 1337 GLN 1338 0.0097

GLN 1338 GLU 1339 0.0189

GLU 1339 ARG 1340 0.0182

ARG 1340 LEU 1341 0.0527

LEU 1341 LYS 1342 0.0013

LYS 1342 GLU 1343 0.0356

GLU 1343 LYS 1344 0.0197

LYS 1344 PHE 1345 0.0363

PHE 1345 GLY 1346 0.0047

GLY 1346 PHE 1347 0.0201

PHE 1347 PRO 1348 0.0038

PRO 1348 LEU 1349 0.0188

LEU 1349 ASP 1350 0.0346

ASP 1350 PRO 1351 0.0004

PRO 1351 THR 1352 0.0365

THR 1352 GLU 1353 0.0248

GLU 1353 ALA 1354 0.0217

ALA 1354 ASP 1355 0.0196

ASP 1355 ILE 1356 0.0230

ILE 1356 ILE 1357 0.0273

ILE 1357 MET 1358 0.0020

MET 1358 GLY 1359 0.0383

GLY 1359 LEU 1360 0.0177

LEU 1360 ARG 1361 0.0327

ARG 1361 GLN 1362 0.0095

GLN 1362 ALA 1363 0.0319

ALA 1363 CYS 1364 0.0302

CYS 1364 ILE 1365 0.0112

ILE 1365 HIS 1366 0.0325

HIS 1366 PHE 1367 0.0174

PHE 1367 ILE 1368 0.0391

ILE 1368 HIS 1369 0.0006

HIS 1369 ARG 1370 0.0391

ARG 1370 SER 1371 0.0168

SER 1371 LEU 1372 0.0332

LEU 1372 GLN 1373 0.0067

GLN 1373 SER 1374 0.0313

SER 1374 LEU 1375 0.0248

LEU 1375 THR 1376 0.0340

THR 1376 ALA 1377 0.0378

ALA 1377 PRO 1378 0.0214

PRO 1378 ASP 1379 0.0315

ASP 1379 ARG 1380 0.0387

ARG 1380 ASP 1381 0.0331

ASP 1381 GLN 1382 0.0204

GLN 1382 LEU 1383 0.0360

LEU 1383 ASP 1384 0.0031

ASP 1384 TRP 1385 0.0377

TRP 1385 HIS 1386 0.0383

HIS 1386 GLN 1387 0.0132

GLN 1387 LYS 1388 0.0298

LYS 1388 ARG 1389 0.0414

ARG 1389 PHE 1390 0.0357

PHE 1390 TYR 1391 0.0087

TYR 1391 ASP 1392 0.0378

ASP 1392 TRP 1393 0.0360

TRP 1393 MET 1394 0.0228

MET 1394 VAL 1395 0.0188

VAL 1395 LEU 1396 0.0365

LEU 1396 GLN 1397 0.0382

GLN 1397 ILE 1398 0.0058

ILE 1398 GLN 1399 0.0361

GLN 1399 LEU 1400 0.0327

LEU 1400 ALA 1401 0.0296

ALA 1401 GLU 1402 0.0108

GLU 1402 GLU 1403 0.0372

GLU 1403 ASP 1404 0.0379

ASP 1404 ARG 1405 0.0082

ARG 1405 LEU 1406 0.0279

LEU 1406 ALA 1407 0.0315

ALA 1407 PRO 1408 0.0089

PRO 1408 ASN 1409 0.0210

ASN 1409 SER 1410 0.0231

SER 1410 SER 1411 0.0183

SER 1411 ALA 1412 0.0327

ALA 1412 TRP 1413 0.0129

TRP 1413 LEU 1414 0.0354

LEU 1414 GLN 1415 0.0115

GLN 1415 CYS 1416 0.0333

CYS 1416 SER 1417 0.0331

SER 1417 SER 1418 0.0251

SER 1418 SER 1419 0.0389

SER 1419 ASP 1420 0.0359

ASP 1420 GLU 1421 0.0173

GLU 1421 GLN 1422 0.0341

GLN 1422 LYS 1423 0.0390

LYS 1423 LEU 1424 0.0316

LEU 1424 LEU 1425 0.0200

LEU 1425 GLU 1426 0.0382

GLU 1426 ASN 1427 0.0389

ASN 1427 VAL 1428 0.0257

VAL 1428 ARG 1429 0.0265

ARG 1429 ALA 1430 0.0388

ALA 1430 SER 1431 0.0384

SER 1431 SER 1432 0.0109

SER 1432 VAL 1433 0.0202

VAL 1433 ASN 1434 0.0331

ASN 1434 GLY 1435 0.0098

GLY 1435 GLN 1436 0.0310

GLN 1436 MET 1437 0.0328

MET 1437 VAL 1438 0.0124

VAL 1438 VAL 1439 0.0275

VAL 1439 HIS 1440 0.0203

HIS 1440 VAL 1441 0.0383

VAL 1441 GLY 1442 0.0038

GLY 1442 LYS 1443 0.0335

LYS 1443 SER 1444 0.0249

SER 1444 MET 1445 0.0384

MET 1445 LEU 1446 0.0264

LEU 1446 ALA 1447 0.0239

ALA 1447 ILE 1448 0.0169

ILE 1448 LEU 1449 0.0300

LEU 1449 ARG 1450 0.0381

ARG 1450 HIS 1451 0.0018

HIS 1451 GLU 1452 0.0374

GLU 1452 ILE 1453 0.0096

ILE 1453 ALA 1454 0.0136

ALA 1454 PRO 1455 0.0376

PRO 1455 LEU 1456 0.0047

LEU 1456 GLU 1457 0.0384

GLU 1457 LEU 1458 0.0097

LEU 1458 MET 1459 0.0337

MET 1459 LEU 1460 0.0118

LEU 1460 GLN 1461 0.0285

GLN 1461 ASP 1462 0.0380

ASP 1462 LYS 1463 0.0233

LYS 1463 LEU 1464 0.0136

LEU 1464 LEU 1465 0.0305

LEU 1465 TYR 1466 0.0167

TYR 1466 ARG 1467 0.0223

ARG 1467 TYR 1468 0.0301

TYR 1468 TYR 1469 0.0008

TYR 1469 THR 1470 0.0356

THR 1470 ASP 1471 0.0090

ASP 1471 ALA 1472 0.0203

ALA 1472 ILE 1473 0.0283

ILE 1473 LYS 1474 0.0292

LYS 1474 TRP 1475 0.0071

TRP 1475 ASP 1476 0.0317

ASP 1476 ARG 1477 0.0355

ARG 1477 SER 1478 0.0290

SER 1478 TYR 1479 0.0146

TYR 1479 GLN 1480 0.0366

GLN 1480 GLN 1481 0.0368

GLN 1481 ILE 1482 0.0169

ILE 1482 ASP 1483 0.0282

ASP 1483 GLN 1484 0.0368

GLN 1484 LEU 1485 0.0340

LEU 1485 VAL 1486 0.0176

VAL 1486 LYS 1487 0.0294

LYS 1487 LEU 1488 0.0335

LEU 1488 HIS 1489 0.0284

HIS 1489 ALA 1490 0.0213

ALA 1490 HIS 1491 0.0312

HIS 1491 LYS 1492 0.0321

LYS 1492 CYS 1493 0.0285

CYS 1493 PRO 1494 0.0313

PRO 1494 THR 1495 0.0257

THR 1495 ALA 1496 0.0125

ALA 1496 LYS 1497 0.0336

LYS 1497 ILE 1498 0.0031

ILE 1498 ILE 1499 0.0232

ILE 1499 GLU 1500 0.0057

GLU 1500 ILE 1501 0.0294

ILE 1501 GLY 1502 0.0202

GLY 1502 ALA 1503 0.0329

ALA 1503 GLY 1504 0.0244

GLY 1504 THR 1505 0.0328

THR 1505 GLY 1506 0.0246

GLY 1506 GLY 1507 0.0147

GLY 1507 CYS 1508 0.0285

CYS 1508 THR 1509 0.0050

THR 1509 ARG 1510 0.0335

ARG 1510 ALA 1511 0.0318

ALA 1511 VAL 1512 0.0149

VAL 1512 LEU 1513 0.0185

LEU 1513 ASP 1514 0.0300

ASP 1514 ALA 1515 0.0336

ALA 1515 LEU 1516 0.0056

LEU 1516 SER 1517 0.0096

SER 1517 ASN 1518 0.0318

ASN 1518 GLN 1519 0.0346

GLN 1519 GLY 1520 0.0319

GLY 1520 ILE 1521 0.0202

ILE 1521 ALA 1522 0.0321

ALA 1522 ARG 1523 0.0342

ARG 1523 CYS 1524 0.0344

CYS 1524 ALA 1525 0.0159

ALA 1525 GLN 1526 0.0228

GLN 1526 TYR 1527 0.0019

TYR 1527 ASP 1528 0.0313

ASP 1528 PHE 1529 0.0108

PHE 1529 THR 1530 0.0280

THR 1530 ASP 1531 0.0114

ASP 1531 VAL 1532 0.0313

VAL 1532 SER 1533 0.0540

SER 1533 SER 1534 0.0190

SER 1534 GLY 1535 0.0152

GLY 1535 PHE 1536 0.0336

PHE 1536 PHE 1537 0.0007

PHE 1537 GLU 1538 0.0332

GLU 1538 ALA 1539 0.0166

ALA 1539 ALA 1540 0.0294

ALA 1540 GLN 1541 0.0041

GLN 1541 GLN 1542 0.0300

GLN 1542 LYS 1543 0.0238

LYS 1543 PHE 1544 0.0155

PHE 1544 ALA 1545 0.0126

ALA 1545 ALA 1546 0.0315

ALA 1546 PHE 1547 0.0317

PHE 1547 ASP 1548 0.0268

ASP 1548 ASP 1549 -0.0117

ASP 1549 VAL 1550 0.0255

VAL 1550 ILE 1551 0.0156

ILE 1551 ARG 1552 0.0321

ARG 1552 PHE 1553 0.0158

PHE 1553 GLN 1554 0.0327

GLN 1554 LYS 1555 0.0164

LYS 1555 LEU 1556 0.0298

LEU 1556 ASP 1557 0.0178

ASP 1557 ILE 1558 0.0324

ILE 1558 GLU 1559 0.0273

GLU 1559 LYS 1560 0.0095

LYS 1560 ASP 1561 0.0083

ASP 1561 ILE 1562 0.0252

ILE 1562 GLU 1563 0.0032

GLU 1563 MET 1564 0.0305

MET 1564 GLN 1565 0.0385

GLN 1565 GLY 1566 0.0092

GLY 1566 PHE 1567 0.0312

PHE 1567 GLU 1568 0.0232

GLU 1568 CYS 1569 0.0269

CYS 1569 GLY 1570 0.0336

GLY 1570 SER 1571 0.0290

SER 1571 TYR 1572 0.0148

TYR 1572 ASP 1573 0.0326

ASP 1573 LEU 1574 0.0066

LEU 1574 VAL 1575 0.0206

VAL 1575 ILE 1576 0.0149

ILE 1576 ALA 1577 0.0125

ALA 1577 SER 1578 0.0136

SER 1578 GLN 1579 0.0114

GLN 1579 VAL 1580 0.0252

VAL 1580 LEU 1581 0.0205

LEU 1581 HIS 1582 0.0014

HIS 1582 ALA 1583 0.0331

ALA 1583 THR 1584 0.0265

THR 1584 GLY 1585 0.0314

GLY 1585 LYS 1586 0.0318

LYS 1586 MET 1587 0.0333

MET 1587 GLU 1588 0.0239

GLU 1588 HIS 1589 0.0206

HIS 1589 THR 1590 0.0343

THR 1590 MET 1591 0.0331

MET 1591 ALA 1592 0.0171

ALA 1592 ASN 1593 0.0269

ASN 1593 VAL 1594 0.0334

VAL 1594 ARG 1595 0.0283

ARG 1595 LYS 1596 0.0112

LYS 1596 LEU 1597 0.0368

LEU 1597 LEU 1598 0.0345

LEU 1598 LYS 1599 0.0152

LYS 1599 PRO 1600 0.0328

PRO 1600 GLY 1601 0.0262

GLY 1601 GLY 1602 0.0335

GLY 1602 LYS 1603 0.0080

LYS 1603 LEU 1604 0.0156

LEU 1604 LEU 1605 0.0221

LEU 1605 LEU 1606 0.0093

LEU 1606 VAL 1607 0.0152

VAL 1607 GLU 1608 0.0170

GLU 1608 THR 1609 0.0007

THR 1609 THR 1610 0.0318

THR 1610 ARG 1611 0.0023

ARG 1611 ASP 1612 0.0305

ASP 1612 GLU 1613 0.0482

GLU 1613 MET 1614 0.0241

MET 1614 ASP 1615 0.0328

ASP 1615 LEU 1616 0.0059

LEU 1616 GLN 1617 0.0349

GLN 1617 LEU 1618 0.0268

LEU 1618 VAL 1619 0.0172

VAL 1619 PHE 1620 0.0176

PHE 1620 GLY 1621 0.0272

GLY 1621 LEU 1622 0.0381

LEU 1622 LEU 1623 0.0011

LEU 1623 PRO 1624 0.0336

PRO 1624 GLY 1625 0.0222

GLY 1625 TRP 1626 0.0173

TRP 1626 TRP 1627 0.0360

TRP 1627 LEU 1628 0.0080

LEU 1628 SER 1629 0.0462

SER 1629 SER 1630 0.0379

SER 1630 GLU 1631 0.0359

GLU 1631 GLU 1632 0.0035

GLU 1632 GLU 1633 0.0376

GLU 1633 ARG 1634 0.0336

ARG 1634 GLN 1635 0.0281

GLN 1635 MET 1636 0.0203

MET 1636 SER 1637 0.0216

SER 1637 PRO 1638 0.0006

PRO 1638 SER 1639 0.0380

SER 1639 LEU 1640 0.0366

LEU 1640 SER 1641 0.0316

SER 1641 THR 1642 0.0235

THR 1642 ASN 1643 0.0369

ASN 1643 SER 1644 0.0351

SER 1644 TRP 1645 0.0341

TRP 1645 GLU 1646 0.0341

GLU 1646 LYS 1647 0.0368

LYS 1647 VAL 1648 0.0286

VAL 1648 LEU 1649 0.0186

LEU 1649 LYS 1650 0.0360

LYS 1650 LYS 1651 0.0366

LYS 1651 THR 1652 0.0219

THR 1652 GLY 1653 0.0186

GLY 1653 PHE 1654 0.0322

PHE 1654 ASP 1655 0.0348

ASP 1655 GLY 1656 0.0052

GLY 1656 LEU 1657 0.0310

LEU 1657 ASP 1658 0.0277

ASP 1658 ILE 1659 0.0233

ILE 1659 GLU 1660 0.0075

GLU 1660 LEU 1661 0.0314

LEU 1661 ARG 1662 0.0088

ARG 1662 ASP 1663 0.0350

ASP 1663 CYS 1664 0.0157

CYS 1664 ASP 1665 0.0322

ASP 1665 SER 1666 0.0111

SER 1666 ASP 1667 0.0352

ASP 1667 GLU 1668 0.0221

GLU 1668 PHE 1669 0.0262

PHE 1669 TYR 1670 0.0027

TYR 1670 SER 1671 0.0301

SER 1671 PHE 1672 0.0007

PHE 1672 SER 1673 0.0229

SER 1673 VAL 1674 0.0044

VAL 1674 MET 1675 0.0299

MET 1675 MET 1676 0.0059

MET 1676 ALA 1677 0.0388

ALA 1677 THR 1678 0.0068

THR 1678 ALA 1679 0.0228

ALA 1679 SER 1680 0.0265

SER 1680 SER 1681 0.0038

SER 1681 THR 1682 0.0236

THR 1682 ILE 1683 0.0215

ILE 1683 ALA 1684 0.0111

ALA 1684 SER 1685 0.0266

SER 1685 SER 1686 0.0052

SER 1686 SER 1687 0.0227

SER 1687 MET 1688 0.0228

MET 1688 ALA 1689 0.0259

ALA 1689 PHE 1690 0.0239

PHE 1690 ALA 1691 0.0252

ALA 1691 ILE 1692 0.0213

ILE 1692 VAL 1693 0.0440

VAL 1693 TYR 1694 0.0277

TYR 1694 GLY 1695 0.0182

GLY 1695 GLU 1696 0.0280

GLU 1696 VAL 1697 0.0015

VAL 1697 PRO 1698 0.0216

PRO 1698 LEU 1699 0.0091

LEU 1699 PRO 1700 0.0068

PRO 1700 ASP 1701 0.0277

ASP 1701 GLN 1702 0.0055

GLN 1702 PHE 1703 0.0245

PHE 1703 LEU 1704 0.0145

LEU 1704 ASP 1705 0.0167

ASP 1705 ASP 1706 0.0186

ASP 1706 MET 1707 0.0103

MET 1707 LYS 1708 0.0263

LYS 1708 THR 1709 0.0091

THR 1709 ALA 1710 0.0288

ALA 1710 ILE 1711 0.0058

ILE 1711 SER 1712 0.0273

SER 1712 SER 1713 0.0083

SER 1713 SER 1714 0.0206

SER 1714 ALA 1715 0.0101

ALA 1715 VAL 1716 0.0275

VAL 1716 SER 1717 0.0210

SER 1717 ASP 1718 0.0277

ASP 1718 PRO 1719 0.0189

PRO 1719 VAL 1720 0.0144

VAL 1720 VAL 1721 0.0284

VAL 1721 GLY 1722 0.0096

GLY 1722 HIS 1723 0.0219

HIS 1723 LEU 1724 0.0164

LEU 1724 ASP 1725 0.0283

ASP 1725 SER 1726 0.0262

SER 1726 ILE 1727 0.0223

ILE 1727 ASP 1728 0.0226

ASP 1728 ALA 1729 0.0265

ALA 1729 THR 1730 0.0198

THR 1730 GLY 1731 0.0216

GLY 1731 LYS 1732 0.0076

LYS 1732 PHE 1733 0.0198

PHE 1733 CYS 1734 0.0280

CYS 1734 ILE 1735 0.0151

ILE 1735 PHE 1736 0.0225

PHE 1736 ILE 1737 0.0163

ILE 1737 GLU 1738 0.0231

GLU 1738 ASP 1739 0.0238

ASP 1739 PRO 1740 0.0259

PRO 1740 GLU 1741 0.0259

GLU 1741 THR 1742 0.0045

THR 1742 ASP 1743 0.0216

ASP 1743 ILE 1744 0.0138

ILE 1744 LEU 1745 0.0219

LEU 1745 SER 1746 0.0281

SER 1746 SER 1747 0.0171

SER 1747 PRO 1748 0.0267

PRO 1748 ASP 1749 0.0198

ASP 1749 GLU 1750 0.0130

GLU 1750 LYS 1751 0.0198

LYS 1751 SER 1752 0.0079

SER 1752 TYR 1753 0.0206

TYR 1753 ALA 1754 0.0217

ALA 1754 SER 1755 0.0074

SER 1755 ILE 1756 0.0239

ILE 1756 GLN 1757 -0.0122

GLN 1757 LYS 1758 0.0268

LYS 1758 LEU 1759 0.0014

LEU 1759 VAL 1760 0.0271

VAL 1760 THR 1761 0.0101

THR 1761 ARG 1762 0.0227

ARG 1762 CYS 1763 0.0018

CYS 1763 LYS 1764 0.0244

LYS 1764 GLY 1765 0.0188

GLY 1765 LEU 1766 0.0243

LEU 1766 ILE 1767 0.0091

ILE 1767 TRP 1768 0.0254

TRP 1768 VAL 1769 0.0086

VAL 1769 SER 1770 0.0273

SER 1770 ARG 1771 0.0164

ARG 1771 GLY 1772 0.0273

GLY 1772 GLY 1773 0.0081

GLY 1773 ALA 1774 0.0222

ALA 1774 MET 1775 0.0122

MET 1775 HIS 1776 0.0245

HIS 1776 GLY 1777 0.0072

GLY 1777 THR 1778 0.0191

THR 1778 ARG 1779 0.0103

ARG 1779 PRO 1780 0.0081

PRO 1780 ASN 1781 0.0171

ASN 1781 SER 1782 0.0163

SER 1782 SER 1783 0.0224

SER 1783 LEU 1784 0.0031

LEU 1784 LYS 1785 0.0234

LYS 1785 THR 1786 0.0210

THR 1786 GLY 1787 0.0066

GLY 1787 LEU 1788 0.0189

LEU 1788 LEU 1789 0.0293

LEU 1789 ARG 1790 0.0274

ARG 1790 THR 1791 0.0009

THR 1791 LEU 1792 0.0274

LEU 1792 ARG 1793 0.0196

ARG 1793 LEU 1794 0.0099

LEU 1794 GLU 1795 0.0164

GLU 1795 TYR 1796 0.0204

TYR 1796 THR 1797 0.0207

THR 1797 GLU 1798 0.0260

GLU 1798 LYS 1799 0.0214

LYS 1799 ARG 1800 0.0043

ARG 1800 PHE 1801 0.0274

PHE 1801 ILE 1802 0.0050

ILE 1802 SER 1803 0.0260

SER 1803 LEU 1804 0.0037

LEU 1804 ASP 1805 0.0223

ASP 1805 LEU 1806 0.0078

LEU 1806 ASP 1807 0.0159

ASP 1807 SER 1808 0.0253

SER 1808 ALA 1809 0.0034

ALA 1809 ARG 1810 0.0247

ARG 1810 PRO 1811 0.0272

PRO 1811 GLN 1812 0.0062

GLN 1812 TRP 1813 0.0259

TRP 1813 ASN 1814 0.0071

ASN 1814 HIS 1815 0.0238

HIS 1815 ASP 1816 0.0274

ASP 1816 SER 1817 0.0005

SER 1817 ILE 1818 0.0273

ILE 1818 THR 1819 0.0192

THR 1819 THR 1820 0.0180

THR 1820 ILE 1821 0.0044

ILE 1821 ASN 1822 0.0242

ASN 1822 GLU 1823 0.0254

GLU 1823 VAL 1824 0.0045

VAL 1824 LEU 1825 0.0235

LEU 1825 CYS 1826 0.0181

CYS 1826 GLY 1827 0.0253

GLY 1827 ALA 1828 0.0023

ALA 1828 LEU 1829 0.0268

LEU 1829 ALA 1830 0.0167

ALA 1830 GLN 1831 0.0171

GLN 1831 ASN 1832 0.0243

ASN 1832 ALA 1833 0.0090

ALA 1833 ASP 1834 0.0248

ASP 1834 SER 1835 0.0239

SER 1835 SER 1836 0.0105

SER 1836 ILE 1837 0.0428

ILE 1837 LYS 1838 0.0259

LYS 1838 ASP 1839 0.0232

ASP 1839 SER 1840 0.0176

SER 1840 GLU 1841 0.0218

GLU 1841 PHE 1842 0.0038

PHE 1842 ALA 1843 0.0192

ALA 1843 GLU 1844 0.0058

GLU 1844 GLN 1845 0.0156

GLN 1845 ASP 1846 0.0031

ASP 1846 GLY 1847 0.0260

GLY 1847 GLN 1848 0.0241

GLN 1848 LEU 1849 0.0047

LEU 1849 PHE 1850 0.0202

PHE 1850 VAL 1851 0.0099

VAL 1851 PRO 1852 0.0157

PRO 1852 ARG 1853 -0.0603

ARG 1853 ILE 1854 0.0134

ILE 1854 SER 1855 0.0230

SER 1855 CYS 1856 0.0222

CYS 1856 ASP 1857 0.0254

ASP 1857 ILE 1858 0.0235

ILE 1858 ALA 1859 0.0246

ALA 1859 ARG 1860 0.0045

ARG 1860 ASN 1861 0.0209

ASN 1861 GLU 1862 0.0190

GLU 1862 ASP 1863 0.0239

ASP 1863 LEU 1864 0.0026

LEU 1864 SER 1865 0.0259

SER 1865 SER 1866 0.0192

SER 1866 ASP 1867 0.0078

ASP 1867 SER 1868 0.0258

SER 1868 ASN 1869 0.2007

ASN 1869 SER 1870 0.0085

SER 1870 PRO 1871 0.0088

PRO 1871 ALA 1872 0.0055

ALA 1872 GLN 1873 0.0104

GLN 1873 MET 1874 0.0102

MET 1874 GLU 1875 0.0009

GLU 1875 PRO 1876 0.0057

PRO 1876 PHE 1877 0.0086

PHE 1877 HIS 1878 0.0026

HIS 1878 GLN 1879 0.0102

GLN 1879 PRO 1880 0.0014

PRO 1880 GLY 1881 0.0095

GLY 1881 LYS 1882 0.0031

LYS 1882 LEU 1883 0.0108

LEU 1883 LEU 1884 0.0021

LEU 1884 GLN 1885 -0.0173

GLN 1885 MET 1886 0.0031

MET 1886 GLY 1887 0.0046

GLY 1887 ILE 1888 0.0006

ILE 1888 LYS 1889 0.0046

LYS 1889 THR 1890 0.0049

THR 1890 PRO 1891 0.0076

PRO 1891 GLY 1892 0.0046

GLY 1892 LEU 1893 0.0082

LEU 1893 ILE 1894 0.0044

ILE 1894 ASP 1895 0.0072

ASP 1895 THR 1896 0.0070

THR 1896 LEU 1897 0.0010

LEU 1897 GLN 1898 0.0066

GLN 1898 PHE 1899 0.0014

PHE 1899 SER 1900 0.0078

SER 1900 LYS 1901 -0.0037

LYS 1901 THR 1902 0.0049

THR 1902 ASP 1903 0.0033

ASP 1903 ALA 1904 0.0019

ALA 1904 THR 1905 0.0049

THR 1905 ASP 1906 0.0020

ASP 1906 ASN 1907 0.0060

ASN 1907 LEU 1908 0.0081

LEU 1908 PRO 1909 0.0076

PRO 1909 ASN 1910 0.0015

ASN 1910 ASP 1911 0.0074

ASP 1911 TYR 1912 0.0039

TYR 1912 ILE 1913 0.0082

ILE 1913 GLU 1914 0.0052

GLU 1914 ILE 1915 0.0067

ILE 1915 GLU 1916 0.0058

GLU 1916 PRO 1917 -0.0061

PRO 1917 LYS 1918 0.0073

LYS 1918 ALA 1919 0.0046

ALA 1919 PHE 1920 0.0059

PHE 1920 GLY 1921 0.0065

GLY 1921 LEU 1922 0.0004

LEU 1922 ASN 1923 0.0071

ASN 1923 PHE 1924 0.0023

PHE 1924 ARG 1925 0.0069

ARG 1925 ASP 1926 0.0071

ASP 1926 VAL 1927 0.0010

VAL 1927 MET 1928 0.0071

MET 1928 VAL 1929 0.0066

VAL 1929 ALA 1930 0.0052

ALA 1930 MET 1931 0.0030

MET 1931 GLY 1932 0.0070

GLY 1932 GLN 1933 -0.0160

GLN 1933 LEU 1934 0.0013

LEU 1934 GLU 1935 0.0065

GLU 1935 GLU 1936 0.0022

GLU 1936 SER 1937 0.0065

SER 1937 ILE 1938 0.0018

ILE 1938 MET 1939 0.0069

MET 1939 GLY 1940 0.0032

GLY 1940 PHE 1941 0.0036

PHE 1941 GLU 1942 0.0042

GLU 1942 CYS 1943 0.0059

CYS 1943 ALA 1944 0.0032

ALA 1944 GLY 1945 0.0053

GLY 1945 VAL 1946 0.0022

VAL 1946 VAL 1947 0.0051

VAL 1947 ARG 1948 0.0068

ARG 1948 ARG 1949 0.0149

ARG 1949 VAL 1950 0.0053

VAL 1950 GLY 1951 0.0074

GLY 1951 PRO 1952 0.0007

PRO 1952 SER 1953 0.0072

SER 1953 SER 1954 0.0059

SER 1954 ALA 1955 0.0033

ALA 1955 GLY 1956 0.0047

GLY 1956 HIS 1957 0.0049

HIS 1957 ASN 1958 0.0071

ASN 1958 ILE 1959 0.0025

ILE 1959 LYS 1960 0.0072

LYS 1960 VAL 1961 0.0049

VAL 1961 GLY 1962 0.0067

GLY 1962 ASP 1963 0.0073

ASP 1963 ARG 1964 0.0030

ARG 1964 VAL 1965 0.0023

VAL 1965 CYS 1966 0.0026

CYS 1966 ALA 1967 0.0068

ALA 1967 LEU 1968 0.0046

LEU 1968 LEU 1969 0.0056

LEU 1969 GLY 1970 0.0066

GLY 1970 GLY 1971 0.0019

GLY 1971 GLN 1972 0.0073

GLN 1972 TRP 1973 0.0069

TRP 1973 THR 1974 0.0052

THR 1974 ASN 1975 0.0056

ASN 1975 THR 1976 0.0026

THR 1976 VAL 1977 0.0073

VAL 1977 ARG 1978 0.0050

ARG 1978 VAL 1979 0.0071

VAL 1979 HIS 1980 0.0037

HIS 1980 TRP 1981 0.0040

TRP 1981 HIS 1982 0.0072

HIS 1982 SER 1983 0.0024

SER 1983 VAL 1984 0.0059

VAL 1984 ALA 1985 0.0056

ALA 1985 PRO 1986 0.0061

PRO 1986 ILE 1987 0.0058

ILE 1987 PRO 1988 0.0060

PRO 1988 GLN 1989 0.0073

GLN 1989 ALA 1990 0.0056

ALA 1990 MET 1991 0.0025

MET 1991 ASP 1992 0.0030

ASP 1992 TRP 1993 0.0058

TRP 1993 GLU 1994 0.0023

GLU 1994 THR 1995 0.0060

THR 1995 ALA 1996 0.0054

ALA 1996 ALA 1997 -0.0048

ALA 1997 SER 1998 0.0067

SER 1998 ILE 1999 0.0048

ILE 1999 PRO 2000 0.0080

PRO 2000 ILE 2001 0.0019

ILE 2001 VAL 2002 0.0079

VAL 2002 PHE 2003 0.0015

PHE 2003 VAL 2004 0.0082

VAL 2004 THR 2005 0.0016

THR 2005 ALA 2006 0.0079

ALA 2006 TYR 2007 0.0011

TYR 2007 ILE 2008 0.0079

ILE 2008 SER 2009 0.0035

SER 2009 LEU 2010 0.0068

LEU 2010 VAL 2011 0.0003

VAL 2011 LYS 2012 0.0083

LYS 2012 ILE 2013 0.0064

ILE 2013 ALA 2014 0.0073

ALA 2014 ARG 2015 0.0004

ARG 2015 MET 2016 0.0074

MET 2016 GLN 2017 0.0049

GLN 2017 ALA 2018 0.0073

ALA 2018 GLY 2019 0.0039

GLY 2019 GLU 2020 0.0036

GLU 2020 THR 2021 0.0015

THR 2021 VAL 2022 0.0065

VAL 2022 LEU 2023 0.0014

LEU 2023 ILE 2024 0.0078

ILE 2024 HIS 2025 0.0021

HIS 2025 ALA 2026 0.0075

ALA 2026 ALA 2027 0.0026

ALA 2027 SER 2028 0.0075

SER 2028 GLY 2029 0.0159

GLY 2029 GLY 2030 0.0018

GLY 2030 VAL 2031 0.0078

VAL 2031 GLY 2032 0.0070

GLY 2032 GLN 2033 0.0046

GLN 2033 ALA 2034 0.0034

ALA 2034 ALA 2035 0.0074

ALA 2035 ILE 2036 0.0080

ILE 2036 ILE 2037 0.0017

ILE 2037 LEU 2038 0.0068

LEU 2038 ALA 2039 0.0065

ALA 2039 LYS 2040 0.0064

LYS 2040 HIS 2041 0.0020

HIS 2041 VAL 2042 0.0079

VAL 2042 GLY 2043 0.0074

GLY 2043 ALA 2044 0.0010

ALA 2044 GLU 2045 0.0153

GLU 2045 ILE 2046 0.0037

ILE 2046 PHE 2047 -0.0001

PHE 2047 ALA 2048 0.0059

ALA 2048 THR 2049 0.0013

THR 2049 VAL 2050 0.0067

VAL 2050 GLY 2051 0.0017

GLY 2051 THR 2052 0.0079

THR 2052 ASP 2053 0.0068

ASP 2053 GLU 2054 0.0052

GLU 2054 LYS 2055 0.0063

LYS 2055 ARG 2056 0.0077

ARG 2056 ASP 2057 0.0062

ASP 2057 LEU 2058 0.0044

LEU 2058 LEU 2059 0.0068

LEU 2059 ILE 2060 0.0078

ILE 2060 LYS 2061 0.0047

LYS 2061 GLU 2062 0.0055

GLU 2062 TYR 2063 0.0076

TYR 2063 LYS 2064 0.0079

LYS 2064 ILE 2065 0.0049

ILE 2065 PRO 2066 0.0064

PRO 2066 ASP 2067 0.0005

ASP 2067 ASP 2068 0.0073

ASP 2068 HIS 2069 0.0066

HIS 2069 ILE 2070 0.0051

ILE 2070 PHE 2071 0.0014

PHE 2071 SER 2072 0.0033

SER 2072 SER 2073 0.0080

SER 2073 ARG 2074 0.0001

ARG 2074 ASN 2075 0.0073

ASN 2075 ALA 2076 0.0072

ALA 2076 LEU 2077 0.0110

LEU 2077 PHE 2078 0.0002

PHE 2078 ALA 2079 0.0071

ALA 2079 LYS 2080 0.0066

LYS 2080 SER 2081 0.0059

SER 2081 ILE 2082 0.0018

ILE 2082 ARG 2083 0.0073

ARG 2083 GLN 2084 0.0071

GLN 2084 ARG 2085 0.0024

ARG 2085 THR 2086 0.0052

THR 2086 ASN 2087 0.0067

ASN 2087 GLY 2088 0.0054

GLY 2088 LYS 2089 0.0026

LYS 2089 GLY 2090 0.0069

GLY 2090 VAL 2091 0.0042

VAL 2091 ASP 2092 0.0028

ASP 2092 VAL 2093 0.0035

VAL 2093 VAL 2094 0.0030

VAL 2094 LEU 2095 0.0077

LEU 2095 ASN 2096 0.0010

ASN 2096 CYS 2097 0.0062

CYS 2097 LEU 2098 0.0011

LEU 2098 ALA 2099 0.0038

ALA 2099 GLY 2100 0.0034

GLY 2100 GLY 2101 0.0074

GLY 2101 LEU 2102 0.0036

LEU 2102 LEU 2103 0.0044

LEU 2103 GLN 2104 0.0066

GLN 2104 GLU 2105 0.0077

GLU 2105 SER 2106 0.0008

SER 2106 PHE 2107 0.0075

PHE 2107 ASP 2108 0.0064

ASP 2108 CYS 2109 0.0035

CYS 2109 LEU 2110 0.0033

LEU 2110 ALA 2111 0.0051

ALA 2111 ASP 2112 0.0075

ASP 2112 PHE 2113 0.0047

PHE 2113 GLY 2114 0.0074

GLY 2114 ARG 2115 0.0078

ARG 2115 PHE 2116 0.0036

PHE 2116 ILE 2117 0.0071

ILE 2117 GLU 2118 0.0037

GLU 2118 ILE 2119 0.0075

ILE 2119 GLY 2120 0.0008

GLY 2120 LYS 2121 0.0070

LYS 2121 ARG 2122 0.0003

ARG 2122 ASP 2123 0.0075

ASP 2123 ILE 2124 0.0048

ILE 2124 GLU 2125 0.0102

GLU 2125 LEU 2126 0.0010

LEU 2126 ASN 2127 0.0071

ASN 2127 HIS 2128 0.0063

HIS 2128 CYS 2129 0.0075

CYS 2129 LEU 2130 0.0042

LEU 2130 ASN 2131 0.0072

ASN 2131 MET 2132 0.0053

MET 2132 GLY 2133 0.0073

GLY 2133 MET 2134 0.0021

MET 2134 PHE 2135 0.0051

PHE 2135 ALA 2136 0.0071

ALA 2136 ARG 2137 0.0046

ARG 2137 SER 2138 0.0039

SER 2138 ALA 2139 0.0074

ALA 2139 THR 2140 0.0064

THR 2140 PHE 2141 -0.0018

PHE 2141 THR 2142 0.0064

THR 2142 ALA 2143 0.0074

ALA 2143 VAL 2144 0.0049

VAL 2144 ASP 2145 0.0082

ASP 2145 LEU 2146 0.0039

LEU 2146 ILE 2147 0.0080

ILE 2147 ALA 2148 0.0082

ALA 2148 ILE 2149 0.0023

ILE 2149 GLY 2150 0.0075

GLY 2150 ARG 2151 0.0080

ARG 2151 ASP 2152 0.0075

ASP 2152 ARG 2153 0.0055

ARG 2153 SER 2154 0.0072

SER 2154 TYR 2155 0.0026

TYR 2155 MET 2156 0.0060

MET 2156 PHE 2157 0.0069

PHE 2157 ALA 2158 0.0003

ALA 2158 GLU 2159 0.0074

GLU 2159 ALA 2160 0.0036

ALA 2160 LEU 2161 0.0075

LEU 2161 PRO 2162 0.0003

PRO 2162 LYS 2163 0.0074

LYS 2163 ILE 2164 0.0026

ILE 2164 MET 2165 0.0060

MET 2165 THR 2166 0.0025

THR 2166 LEU 2167 0.0053

LEU 2167 LEU 2168 0.0062

LEU 2168 GLN 2169 0.0017

GLN 2169 GLU 2170 0.0065

GLU 2170 LYS 2171 0.0023

LYS 2171 ALA 2172 0.0075

ALA 2172 ILE 2173 -0.0086

ILE 2173 ARG 2174 0.0052

ARG 2174 PRO 2175 0.0045

PRO 2175 VAL 2176 0.0003

VAL 2176 THR 2177 0.0054

THR 2177 PRO 2178 0.0041

PRO 2178 ILE 2179 0.0078

ILE 2179 SER 2180 0.0024

SER 2180 ILE 2181 0.0075

ILE 2181 TYR 2182 0.0048

TYR 2182 LYS 2183 0.0078

LYS 2183 ILE 2184 0.0079

ILE 2184 GLY 2185 0.0038

GLY 2185 ASP 2186 0.0063

ASP 2186 ILE 2187 0.0079

ILE 2187 GLU 2188 0.0003

GLU 2188 THR 2189 0.0010

THR 2189 ALA 2190 0.0030

ALA 2190 PHE 2191 0.0069

PHE 2191 ARG 2192 0.0021

ARG 2192 LEU 2193 0.0065

LEU 2193 MET 2194 0.0061

MET 2194 GLN 2195 0.0024

GLN 2195 ALA 2196 0.0063

ALA 2196 GLY 2197 0.0035

GLY 2197 LYS 2198 0.0078

LYS 2198 HIS 2199 0.0004

HIS 2199 MET 2200 0.0038

MET 2200 GLY 2201 0.0010

GLY 2201 LYS 2202 0.0078

LYS 2202 ILE 2203 0.0067

ILE 2203 VAL 2204 0.0045

VAL 2204 ILE 2205 0.0119

ILE 2205 THR 2206 0.0051

THR 2206 ALA 2207 0.0060

ALA 2207 PRO 2208 0.0062

PRO 2208 GLU 2209 0.0055

GLU 2209 ASP 2210 0.0006

ASP 2210 ALA 2211 0.0054

ALA 2211 MET 2212 0.0041

MET 2212 VAL 2213 0.0060

VAL 2213 PRO 2214 0.0047

PRO 2214 VAL 2215 0.0034

VAL 2215 ILE 2216 0.0060

ILE 2216 THR 2217 0.0041

THR 2217 ARG 2218 0.0059

ARG 2218 PRO 2219 0.0059

PRO 2219 PRO 2220 0.0006

PRO 2220 LYS 2221 0.0106

LYS 2221 LEU 2222 0.0214

LEU 2222 GLN 2223 0.0233

GLN 2223 LEU 2224 0.0200

LEU 2224 ARG 2225 0.0246

ARG 2225 PRO 2226 0.0050

PRO 2226 ASP 2227 0.0239

ASP 2227 ALA 2228 0.0241

ALA 2228 SER 2229 0.0173

SER 2229 TYR 2230 0.0241

TYR 2230 LEU 2231 0.0229

LEU 2231 ILE 2232 0.0222

ILE 2232 VAL 2233 0.0240

VAL 2233 GLY 2234 0.0132

GLY 2234 GLY 2235 0.0237

GLY 2235 LEU 2236 0.0040

LEU 2236 GLY 2237 -0.0277

GLY 2237 GLY 2238 0.0203

GLY 2238 ILE 2239 0.0023

ILE 2239 GLY 2240 0.0196

GLY 2240 ARG 2241 0.0104

ARG 2241 SER 2242 0.0121

SER 2242 LEU 2243 0.0124

LEU 2243 CYS 2244 0.0100

CYS 2244 LYS 2245 0.0199

LYS 2245 ASN 2246 0.0017

ASN 2246 PHE 2247 0.0203

PHE 2247 VAL 2248 0.0088

VAL 2248 GLU 2249 0.0195

GLU 2249 ASN 2250 0.0032

ASN 2250 GLY 2251 0.0191

GLY 2251 ALA 2252 0.0191

ALA 2252 ARG 2253 0.0002

ARG 2253 SER 2254 0.0238

SER 2254 LEU 2255 0.0240

LEU 2255 VAL 2256 0.0237

VAL 2256 LEU 2257 0.0206

LEU 2257 LEU 2258 0.0235

LEU 2258 SER 2259 0.0158

SER 2259 ARG 2260 0.0215

ARG 2260 ASN 2261 0.0030

ASN 2261 ALA 2262 0.0238

ALA 2262 ASN 2263 0.0005

ASN 2263 VAL 2264 0.0232

VAL 2264 SER 2265 0.0230

SER 2265 GLN 2266 0.0098

GLN 2266 GLN 2267 0.0167

GLN 2267 SER 2268 0.0112

SER 2268 GLY 2269 0.0282

GLY 2269 GLU 2270 0.0243

GLU 2270 PHE 2271 -0.0002

PHE 2271 LEU 2272 0.0245

LEU 2272 ASP 2273 0.0141

ASP 2273 GLU 2274 0.0178

GLU 2274 LEU 2275 0.0076

LEU 2275 ARG 2276 0.0194

ARG 2276 SER 2277 0.0209

SER 2277 THR 2278 0.0031

THR 2278 GLY 2279 0.0243

GLY 2279 CYS 2280 0.0163

CYS 2280 ILE 2281 0.0240

ILE 2281 VAL 2282 0.0242

VAL 2282 GLY 2283 0.0244

GLY 2283 VAL 2284 0.0225

VAL 2284 VAL 2285 0.1082

VAL 2285 ASP 2286 0.0217

ASP 2286 CYS 2287 0.0043

CYS 2287 ASP 2288 0.0189

ASP 2288 ILE 2289 0.0020

ILE 2289 SER 2290 0.0208

SER 2290 SER 2291 0.0201

SER 2291 LYS 2292 0.0127

LYS 2292 THR 2293 0.0115

THR 2293 GLN 2294 0.0147

GLN 2294 VAL 2295 0.0098

VAL 2295 GLU 2296 0.0210

GLU 2296 ALA 2297 0.0021

ALA 2297 THR 2298 0.0225

THR 2298 MET 2299 0.0071

MET 2299 LEU 2300 0.0209

LEU 2300 ARG 2301 0.0116

ARG 2301 LEU 2302 0.0173

LEU 2302 LYS 2303 0.0123

LYS 2303 LYS 2304 0.0077

LYS 2304 ASP 2305 0.0130

ASP 2305 MET 2306 0.0137

MET 2306 LEU 2307 0.0079

LEU 2307 PRO 2308 0.0045

PRO 2308 ILE 2309 0.0203

ILE 2309 ARG 2310 0.0095

ARG 2310 GLY 2311 0.0207

GLY 2311 ILE 2312 0.0185

ILE 2312 VAL 2313 0.0197

VAL 2313 HIS 2314 0.0203

HIS 2314 ALA 2315 0.0139

ALA 2315 GLY 2316 0.0172

GLY 2316 MET 2317 0.0655

MET 2317 VAL 2318 0.0144

VAL 2318 LEU 2319 0.0231

LEU 2319 GLN 2320 0.0217

GLN 2320 ASP 2321 0.0233

ASP 2321 SER 2322 0.0235

SER 2322 VAL 2323 0.0159

VAL 2323 PHE 2324 0.0125

PHE 2324 GLU 2325 0.0211

GLU 2325 ARG 2326 0.0049

ARG 2326 MET 2327 0.0214

MET 2327 SER 2328 0.0220

SER 2328 LEU 2329 0.0148

LEU 2329 ASP 2330 0.0130

ASP 2330 ASP 2331 0.0236

ASP 2331 TYR 2332 0.0000

TYR 2332 ASN 2333 0.0460

ASN 2333 THR 2334 0.0086

THR 2334 ALA 2335 0.0162

ALA 2335 ILE 2336 0.0030

ILE 2336 ARG 2337 0.0194

ARG 2337 PRO 2338 0.0201

PRO 2338 LYS 2339 0.0066

LYS 2339 VAL 2340 0.0132

VAL 2340 GLN 2341 0.0191

GLN 2341 GLY 2342 0.0164

GLY 2342 SER 2343 0.0076

SER 2343 TRP 2344 0.0135

TRP 2344 ASN 2345 0.0130

ASN 2345 LEU 2346 0.0207

LEU 2346 HIS 2347 0.0001

HIS 2347 SER 2348 0.0202

SER 2348 GLY 2349 0.0200

GLY 2349 LEU 2350 0.0167

LEU 2350 SER 2351 0.0036

SER 2351 ASP 2352 0.0201

ASP 2352 CYS 2353 0.0191

CYS 2353 ASP 2354 0.0115

ASP 2354 LEU 2355 0.0184

LEU 2355 ASP 2356 0.0191

ASP 2356 PHE 2357 0.0191

PHE 2357 PHE 2358 0.0187

PHE 2358 ILE 2359 0.0182

ILE 2359 MET 2360 0.0185

MET 2360 LEU 2361 0.0148

LEU 2361 SER 2362 0.0177

SER 2362 SER 2363 0.0199

SER 2363 LEU 2364 0.0151

LEU 2364 ALA 2365 0.0110

ALA 2365 GLY 2366 0.0120

GLY 2366 VAL 2367 0.0128

VAL 2367 SER 2368 0.0188

SER 2368 GLY 2369 0.0179

GLY 2369 SER 2370 0.0007

SER 2370 ALA 2371 0.0179

ALA 2371 SER 2372 0.0143

SER 2372 GLN 2373 0.0192

GLN 2373 ALA 2374 0.0115

ALA 2374 ASN 2375 0.0224

ASN 2375 TYR 2376 0.0236

TYR 2376 THR 2377 0.0071

THR 2377 ALA 2378 0.0189

ALA 2378 GLY 2379 0.0210

GLY 2379 GLY 2380 0.0206

GLY 2380 ALA 2381 -0.0012

ALA 2381 TYR 2382 0.0228

TYR 2382 GLN 2383 0.0221

GLN 2383 ASP 2384 0.0099

ASP 2384 ALA 2385 0.0145

ALA 2385 LEU 2386 0.0199

LEU 2386 ALA 2387 0.0215

ALA 2387 LYS 2388 0.0027

LYS 2388 TYR 2389 0.0227

TYR 2389 ARG 2390 0.0207

ARG 2390 ARG 2391 0.0134

ARG 2391 ALA 2392 0.0103

ALA 2392 GLN 2393 0.0214

GLN 2393 GLY 2394 0.0225

GLY 2394 LEU 2395 0.0001

LEU 2395 SER 2396 0.0153

SER 2396 ALA 2397 -0.0029

ALA 2397 VAL 2398 0.0190

VAL 2398 SER 2399 0.0152

SER 2399 ILE 2400 0.0159

ILE 2400 ASP 2401 0.0189

ASP 2401 LEU 2402 0.0078

LEU 2402 GLY 2403 0.0186

GLY 2403 MET 2404 0.0028

MET 2404 VAL 2405 0.0162

VAL 2405 GLN 2406 0.0130

GLN 2406 SER 2407 0.0132

SER 2407 VAL 2408 0.0194

VAL 2408 GLY 2409 0.0193

GLY 2409 TYR 2410 0.0188

TYR 2410 VAL 2411 0.0183

VAL 2411 ALA 2412 0.0142

ALA 2412 GLU 2413 0.0198

GLU 2413 THR 2414 0.0213

THR 2414 LYS 2415 0.0201

LYS 2415 GLY 2416 0.0132

GLY 2416 VAL 2417 0.0087

VAL 2417 ALA 2418 0.0146

ALA 2418 GLU 2419 0.0212

GLU 2419 ARG 2420 0.0198

ARG 2420 LEU 2421 0.0084

LEU 2421 VAL 2422 0.0186

VAL 2422 ARG 2423 0.0210

ARG 2423 MET 2424 0.0154

MET 2424 GLY 2425 0.0102

GLY 2425 TYR 2426 0.0198

TYR 2426 SER 2427 0.0209

SER 2427 PRO 2428 0.0106

PRO 2428 ILE 2429 0.0388

ILE 2429 SER 2430 0.0114

SER 2430 GLU 2431 0.0149

GLU 2431 MET 2432 0.0113

MET 2432 GLU 2433 0.0056

GLU 2433 VAL 2434 0.0163

VAL 2434 LEU 2435 0.0172

LEU 2435 LYS 2436 0.0046

LYS 2436 ILE 2437 0.0134

ILE 2437 VAL 2438 0.0146

VAL 2438 GLU 2439 0.0165

GLU 2439 HIS 2440 0.0021

HIS 2440 ALA 2441 0.0174

ALA 2441 ILE 2442 0.0165

ILE 2442 THR 2443 0.0112

THR 2443 ASN 2444 0.0067

ASN 2444 PRO 2445 0.0448

PRO 2445 PRO 2446 0.0149

PRO 2446 PRO 2447 0.0035

PRO 2447 GLU 2448 0.0207

GLU 2448 ALA 2449 0.0149

ALA 2449 SER 2450 0.0213

SER 2450 SER 2451 0.0172

SER 2451 ALA 2452 0.0097

ALA 2452 GLN 2453 0.0130

GLN 2453 ILE 2454 0.0175

ILE 2454 ILE 2455 0.0171

ILE 2455 THR 2456 0.0105

THR 2456 GLY 2457 0.0114

GLY 2457 ILE 2458 0.0162

ILE 2458 SER 2459 0.0210

SER 2459 THR 2460 0.0064

THR 2460 LYS 2461 0.0579

LYS 2461 PRO 2462 0.0235

PRO 2462 GLY 2463 0.0068

GLY 2463 ARG 2464 0.0182

ARG 2464 HIS 2465 0.0232

HIS 2465 TRP 2466 0.0024

TRP 2466 THR 2467 0.0211

THR 2467 GLU 2468 0.0063

GLU 2468 SER 2469 0.0219

SER 2469 SER 2470 0.0208

SER 2470 TRP 2471 0.0182

TRP 2471 LEU 2472 0.0173

LEU 2472 GLN 2473 0.0202

GLN 2473 ASP 2474 0.0185

ASP 2474 ALA 2475 0.0003

ALA 2475 ARG 2476 0.0234

ARG 2476 PHE 2477 0.0130

PHE 2477 ALA 2478 0.0170

ALA 2478 THR 2479 0.0185

THR 2479 LEU 2480 0.0069

LEU 2480 ARG 2481 0.0210

ARG 2481 GLU 2482 0.0104

GLU 2482 ARG 2483 0.0241

ARG 2483 ALA 2484 0.0025

ALA 2484 ARG 2485 0.0220

ARG 2485 ASP 2486 0.0130

ASP 2486 VAL 2487 0.0120

VAL 2487 LYS 2488 0.0183

LYS 2488 GLU 2489 0.0108

GLU 2489 LEU 2490 0.0222

LEU 2490 SER 2491 0.0040

SER 2491 ASN 2492 0.0236

ASN 2492 SER 2493 -0.0137

SER 2493 GLN 2494 0.0245

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** sdgklnrdh ***

CA strain for 22101813491974862

--- normal mode 10 ---

Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *