Should you encounter any unexpected behaviour,
please let us know.

* HYDROLASE/HYDROLASE INHIBITOR 04-OCT-16 5H08 *

CA distance fluctuations for 2502261434124124660

--- normal mode 9 ---

This matrix displays the maximum distance fluctuations between all pairs of CA atoms and between the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Distance increases are plotted in blue and decreases in red for the strongest 10% of the residue pair distance changes. Every pixel corresponds to a single residue. Grey lines are drawn every 10 residues, yellow lines every 100 residues (counting from the upper left corner).

The following table indicates for every residue the two corresponding residues with the strongest CA distance fluctuations.

[HELP on distance fluctuations]

GD ok

largest increase ref largest decrease
ARG 1834 0.17 GLY 1696 -0.14 ASN 1792

ARG 1834 0.14 PRO 1697 -0.15 ASN 1792

ARG 1834 0.11 ALA 1698 -0.13 ASN 1792

ARG 1834 0.10 ILE 1699 -0.08 ASN 1792

SER 1995 0.08 PRO 1700 -0.09 ARG 1916

SER 1995 0.09 ILE 1701 -0.08 ARG 1916

ASP 1776 0.09 LYS 1702 -0.05 ASN 1746

TYR 1907 0.09 HIS 1703 -0.07 ASN 1746

TYR 1907 0.11 PHE 1704 -0.08 ASN 1746

TYR 1907 0.16 PRO 1705 -0.10 ASN 1746

TYR 1907 0.20 LYS 1706 -0.11 ASN 1746

TYR 1907 0.17 HIS 1707 -0.11 ASN 1746

TYR 1907 0.22 VAL 1708 -0.13 ASN 1746

TYR 1907 0.29 ALA 1709 -0.13 ASN 1746

TYR 1907 0.25 ASP 1710 -0.14 ASN 1746

VAL 1904 0.27 LEU 1711 -0.16 ASN 1746

VAL 1904 0.35 HIS 1712 -0.17 ASN 1746

VAL 1904 0.32 ALA 1713 -0.16 ASN 1746

VAL 1904 0.32 SER 1714 -0.17 ASN 1746

VAL 1904 0.37 SER 1715 -0.18 ASN 1746

LYS 1832 0.26 GLY 1716 -0.19 ASN 1746

LYS 1832 0.27 PHE 1717 -0.19 ASN 1746

LYS 1832 0.33 THR 1718 -0.22 ASN 1746

LYS 1832 0.30 GLU 1719 -0.21 ALA 1742

LYS 1832 0.26 GLU 1720 -0.19 ALA 1742

LYS 1832 0.29 PHE 1721 -0.21 ALA 1742

LYS 1832 0.32 GLU 1722 -0.25 ALA 1742

GLY 1833 0.28 GLU 1730 -0.20 ALA 1742

ARG 1834 0.26 VAL 1731 -0.19 ALA 1742

ARG 1834 0.32 GLN 1732 -0.27 ALA 1742

GLY 1833 0.30 SER 1733 -0.26 ALA 1742

ARG 1834 0.29 CYS 1734 -0.19 GLY 1777

ARG 1834 0.29 THR 1735 -0.21 GLY 1777

ASN 1758 0.52 VAL 1736 -0.18 GLY 1777

ASN 1758 0.57 ASP 1737 -0.23 GLY 1777

ASN 1758 0.41 LEU 1738 -0.28 GLY 1777

ASN 1758 0.34 GLY 1739 -0.36 GLY 1777

ASN 1758 0.28 ILE 1740 -0.31 GLY 1777

ASN 1758 0.23 THR 1741 -0.34 GLY 1777

ILE 1757 0.11 ALA 1742 -0.27 GLN 1732

PRO 1794 0.10 ASP 1743 -0.35 GLY 1777

PRO 1794 0.10 SER 1744 -0.30 GLY 1777

ASP 1737 0.12 SER 1745 -0.22 VAL 1904

LYS 1751 0.12 ASN 1746 -0.25 VAL 1904

GLY 1850 0.11 HIS 1747 -0.22 VAL 1904

GLY 1850 0.12 PRO 1748 -0.23 VAL 1904

GLY 1850 0.16 ASP 1749 -0.18 VAL 1904

ASP 1776 0.16 ASN 1750 -0.19 VAL 1904

ASP 1776 0.19 LYS 1751 -0.23 VAL 1904

ASP 1776 0.36 HIS 1752 -0.20 VAL 1904

ASP 1776 0.35 LYS 1753 -0.18 VAL 1904

ASP 1737 0.27 ASN 1754 -0.24 VAL 1904

ASP 1737 0.33 ARG 1755 -0.26 VAL 1904

ASP 1737 0.41 TYR 1756 -0.32 VAL 1904

ASP 1737 0.42 ILE 1757 -0.31 VAL 1904

ASP 1737 0.57 ASN 1758 -0.31 VAL 1904

ASP 1737 0.49 ILE 1759 -0.28 VAL 1904

ASP 1737 0.35 VAL 1760 -0.23 VAL 1904

ASP 1737 0.18 ALA 1761 -0.18 VAL 1904

ILE 1759 0.12 TYR 1762 -0.23 GLN 1732

PRO 1794 0.13 ASP 1763 -0.32 GLY 1777

ASN 1792 0.12 HIS 1764 -0.30 GLY 1777

PRO 1794 0.14 SER 1765 -0.21 LEU 1738

PRO 1794 0.12 ARG 1766 -0.17 GLN 1732

LYS 1795 0.13 VAL 1767 -0.15 GLY 1739

ARG 1793 0.12 LYS 1768 -0.21 GLY 1739

VAL 1926 0.13 LEU 1769 -0.17 GLY 1739

VAL 1926 0.13 ALA 1770 -0.22 GLY 1739

VAL 1926 0.11 GLN 1771 -0.27 GLY 1739

ASN 1851 0.29 LEU 1772 -0.26 GLN 1771

GLY 1850 0.54 ALA 1773 -0.32 GLY 1739

GLY 1850 1.08 GLU 1774 -0.24 GLY 1739

GLY 1850 1.01 LYS 1775 -0.28 GLY 1739

GLY 1850 0.93 ASP 1776 -0.20 GLY 1739

GLY 1850 0.68 GLY 1777 -0.36 GLY 1739

GLY 1850 0.36 LYS 1778 -0.22 ASP 1743

GLY 1850 0.25 LEU 1779 -0.28 SER 1744

LEU 1779 0.18 THR 1780 -0.15 GLY 1739

VAL 1926 0.11 ASP 1781 -0.18 LEU 1772

ASP 1776 0.12 TYR 1782 -0.15 VAL 1904

ASP 1776 0.24 ILE 1783 -0.15 VAL 1904

ASP 1776 0.21 ASN 1784 -0.18 VAL 1904

ASP 1776 0.18 ALA 1785 -0.15 VAL 1904

ASP 1776 0.10 ASN 1786 -0.12 VAL 1904

LYS 1795 0.13 TYR 1787 -0.18 LEU 1738

ASP 1776 0.10 VAL 1788 -0.14 LEU 1738

GLY 1790 0.13 ASP 1789 -0.17 LEU 1738

ASP 1789 0.13 GLY 1790 -0.13 ARG 1923

SER 1995 0.12 TYR 1791 -0.19 ARG 1923

SER 1995 0.13 ASN 1792 -0.18 ARG 1923

SER 1995 0.14 ARG 1793 -0.18 LEU 1738

SER 1765 0.14 PRO 1794 -0.23 LEU 1738

TYR 1787 0.13 LYS 1795 -0.22 LEU 1738

ASP 1776 0.15 ALA 1796 -0.16 LEU 1738

ASP 1776 0.18 TYR 1797 -0.12 LEU 1738

ASP 1776 0.19 ILE 1798 -0.10 LEU 1738

ASP 1776 0.19 ALA 1799 -0.13 VAL 1904

ASP 1776 0.25 ALA 1800 -0.15 VAL 1904

ASP 1776 0.29 GLN 1801 -0.20 VAL 1904

ASP 1776 0.36 GLY 1802 -0.15 VAL 1904

ASP 1776 0.46 PRO 1803 -0.13 VAL 1904

ASP 1776 0.52 LEU 1804 -0.14 VAL 1904

ASP 1776 0.65 LYS 1805 -0.10 VAL 1904

ASP 1776 0.71 SER 1806 -0.12 VAL 1904

ASP 1776 0.60 THR 1807 -0.12 VAL 1904

ASP 1776 0.63 ALA 1808 -0.08 VAL 1904

GLU 1774 0.70 GLU 1809 -0.07 VAL 1904

ASP 1776 0.54 ASP 1810 -0.10 VAL 1904

ASP 1776 0.47 PHE 1811 -0.09 VAL 1904

GLU 1774 0.52 TRP 1812 -0.09 HIS 1764

GLU 1774 0.50 ARG 1813 -0.12 GLY 1739

GLU 1774 0.35 MET 1814 -0.13 GLY 1739

GLU 1774 0.38 ILE 1815 -0.12 GLY 1739

GLU 1774 0.40 TRP 1816 -0.16 GLY 1739

GLU 1774 0.28 GLU 1817 -0.21 GLY 1739

GLU 1774 0.23 HIS 1818 -0.21 GLY 1739

GLU 1774 0.27 ASN 1819 -0.19 LEU 1738

GLU 1774 0.30 VAL 1820 -0.15 LEU 1738

GLU 1774 0.32 GLU 1821 -0.15 VAL 1891

LYS 1775 0.32 VAL 1822 -0.12 ALA 1796

LYS 1775 0.33 ILE 1823 -0.08 ALA 1796

LYS 1775 0.31 VAL 1824 -0.09 HIS 1955

LYS 1775 0.33 MET 1825 -0.07 GLN 1954

LYS 1775 0.28 ILE 1826 -0.11 VAL 1911

LYS 1775 0.31 THR 1827 -0.13 TYR 1907

LYS 1775 0.36 ASN 1828 -0.10 TYR 1907

LYS 1775 0.40 LEU 1829 -0.09 TYR 1907

LYS 1775 0.35 VAL 1830 -0.12 TYR 1907

THR 1978 0.35 GLU 1831 -0.15 TYR 1907

VAL 1736 0.38 LYS 1832 -0.15 TYR 1907

VAL 1736 0.41 GLY 1833 -0.13 TYR 1907

VAL 1736 0.43 ARG 1834 -0.11 TYR 1907

VAL 1736 0.38 ARG 1835 -0.11 TYR 1907

VAL 1736 0.35 LYS 1836 -0.16 VAL 1904

ASP 1776 0.40 CYS 1837 -0.12 VAL 1904

ASP 1776 0.49 ASP 1838 -0.08 VAL 1904

LYS 1775 0.53 GLN 1839 -0.06 HIS 1924

LYS 1775 0.58 TYR 1840 -0.05 GLU 1821

LYS 1775 0.59 TRP 1841 -0.07 ALA 1925

LYS 1775 0.64 PRO 1842 -0.08 HIS 1924

LYS 1775 0.59 ALA 1843 -0.09 HIS 1924

LYS 1775 0.60 ASP 1844 -0.10 HIS 1924

LYS 1775 0.62 GLY 1845 -0.11 HIS 1924

LYS 1775 0.70 SER 1846 -0.09 VAL 1926

LYS 1775 0.79 GLU 1847 -0.06 VAL 1926

LYS 1775 0.89 GLU 1848 -0.06 HIS 1764

LYS 1775 0.87 TYR 1849 -0.05 HIS 1764

GLU 1774 1.08 GLY 1850 -0.06 HIS 1764

GLU 1774 0.92 ASN 1851 -0.10 GLY 1739

GLU 1774 0.75 PHE 1852 -0.09 HIS 1764

LYS 1775 0.73 LEU 1853 -0.08 HIS 1764

LYS 1775 0.65 VAL 1854 -0.09 VAL 1926

LYS 1775 0.61 THR 1855 -0.11 VAL 1926

LYS 1775 0.56 GLN 1856 -0.13 ALA 1925

LYS 1775 0.51 LYS 1857 -0.16 HIS 1924

LYS 1775 0.47 SER 1858 -0.16 HIS 1924

LYS 1775 0.44 VAL 1859 -0.15 HIS 1924

LYS 1775 0.40 GLN 1860 -0.17 HIS 1955

LYS 1775 0.39 VAL 1861 -0.15 HIS 1955

LYS 1775 0.34 LEU 1862 -0.16 GLN 1954

LYS 1775 0.32 ALA 1863 -0.15 GLN 1954

LYS 1775 0.30 TYR 1864 -0.14 GLN 1954

LYS 1775 0.33 TYR 1865 -0.14 GLN 1954

LYS 1775 0.38 THR 1866 -0.14 HIS 1955

LYS 1775 0.39 VAL 1867 -0.15 HIS 1955

LYS 1775 0.44 ARG 1868 -0.14 HIS 1924

LYS 1775 0.45 ASN 1869 -0.17 ALA 1925

LYS 1775 0.50 PHE 1870 -0.14 ALA 1925

LYS 1775 0.51 THR 1871 -0.14 VAL 1926

LYS 1775 0.52 LEU 1872 -0.10 GLY 1739

LYS 1775 0.57 ARG 1873 -0.12 GLY 1739

GLU 1774 0.59 ASN 1874 -0.14 GLY 1739

LYS 1775 0.67 THR 1875 -0.13 GLY 1739

LYS 1775 0.55 LYS 1876 -0.18 GLY 1739

LYS 1775 0.40 ILE 1877 -0.20 GLY 1739

LYS 1775 0.41 ARG 1889 -0.13 VAL 1926

LYS 1775 0.40 VAL 1890 -0.17 VAL 1926

LYS 1775 0.41 VAL 1891 -0.15 GLU 1821

LYS 1775 0.38 THR 1892 -0.16 ALA 1925

LYS 1775 0.40 GLN 1893 -0.11 HIS 1955

LYS 1775 0.35 TYR 1894 -0.12 HIS 1955

LYS 1775 0.36 HIS 1895 -0.11 HIS 1955

LYS 1775 0.31 TYR 1896 -0.11 GLN 1954

LYS 1775 0.33 THR 1897 -0.11 GLY 1833

GLU 1980 0.33 GLN 1898 -0.14 SER 1995

GLU 1980 0.32 TRP 1899 -0.23 TYR 1907

GLU 1980 0.29 PRO 1900 -0.30 TYR 1907

SER 1715 0.29 ASP 1901 -0.25 TYR 1907

SER 1715 0.31 MET 1902 -0.26 TYR 1907

SER 1715 0.35 GLY 1903 -0.27 TYR 1756

SER 1715 0.37 VAL 1904 -0.32 TYR 1756

SER 1715 0.29 PRO 1905 -0.25 TYR 1756

HIS 1712 0.29 GLU 1906 -0.22 ASN 1758

HIS 1712 0.31 TYR 1907 -0.30 PRO 1900

ALA 1709 0.22 SER 1908 -0.21 PRO 1900

LYS 1775 0.20 LEU 1909 -0.21 SER 1995

LYS 1775 0.24 PRO 1910 -0.17 PRO 1900

LYS 1775 0.22 VAL 1911 -0.17 TRP 1899

LYS 1775 0.21 LEU 1912 -0.17 GLN 1954

LYS 1775 0.25 THR 1913 -0.22 GLN 1954

LYS 1775 0.27 PHE 1914 -0.18 GLN 1954

LYS 1775 0.24 VAL 1915 -0.18 GLN 1951

LYS 1775 0.24 ARG 1916 -0.28 GLN 1954

LYS 1775 0.28 LYS 1917 -0.24 GLN 1954

LYS 1775 0.28 ALA 1918 -0.18 HIS 1955

LYS 1775 0.22 ALA 1919 -0.20 GLN 1951

LYS 1775 0.25 TYR 1920 -0.25 HIS 1955

LYS 1775 0.29 ALA 1921 -0.18 HIS 1955

GLU 1774 0.26 LYS 1922 -0.15 TYR 1791

SER 1995 0.24 ARG 1923 -0.19 TYR 1791

GLU 1774 0.22 HIS 1924 -0.17 ASN 1869

GLU 1774 0.24 ALA 1925 -0.17 ASN 1869

GLU 1774 0.21 VAL 1926 -0.17 LEU 1738

GLU 1774 0.22 GLY 1927 -0.18 LEU 1738

ASP 1776 0.20 PRO 1928 -0.16 LEU 1738

ASP 1776 0.25 VAL 1929 -0.11 LEU 1738

ASP 1776 0.28 VAL 1930 -0.07 VAL 1904

ASP 1776 0.26 VAL 1931 -0.10 VAL 1904

ASP 1776 0.28 HIS 1932 -0.13 VAL 1904

ASP 1776 0.28 CYS 1933 -0.18 VAL 1904

VAL 1736 0.32 SER 1934 -0.24 VAL 1904

VAL 1736 0.35 ALA 1935 -0.28 VAL 1904

ASP 1737 0.26 GLY 1936 -0.21 VAL 1904

VAL 1736 0.28 VAL 1937 -0.20 VAL 1904

VAL 1736 0.28 GLY 1938 -0.23 VAL 1904

VAL 1736 0.23 ARG 1939 -0.21 VAL 1904

ASP 1776 0.20 THR 1940 -0.16 VAL 1904

VAL 1736 0.16 GLY 1941 -0.12 VAL 1904

ASP 1776 0.16 THR 1942 -0.13 GLU 1906

ASP 1776 0.18 TYR 1943 -0.11 VAL 1911

ASP 1776 0.16 ILE 1944 -0.08 VAL 1904

ASP 1776 0.13 VAL 1945 -0.08 ASN 1746

ASP 1776 0.15 LEU 1946 -0.09 LEU 1912

ASP 1776 0.16 ASP 1947 -0.09 VAL 1915

ASP 1776 0.14 SER 1948 -0.10 LYS 1917

ASP 1776 0.12 MET 1949 -0.11 ARG 1916

SER 1995 0.16 LEU 1950 -0.19 ARG 1916

SER 1995 0.18 GLN 1951 -0.26 ARG 1916

SER 1995 0.15 GLN 1952 -0.18 ARG 1916

SER 1995 0.15 ILE 1953 -0.19 ARG 1916

SER 1995 0.21 GLN 1954 -0.28 ARG 1916

SER 1995 0.17 HIS 1955 -0.25 TYR 1920

SER 1995 0.13 GLU 1956 -0.19 ARG 1916

SER 1995 0.13 GLY 1957 -0.17 ARG 1916

SER 1995 0.10 THR 1958 -0.13 ARG 1916

ASP 1776 0.08 VAL 1959 -0.10 ARG 1916

ARG 1834 0.12 ASN 1960 -0.11 ASN 1792

ARG 1834 0.14 ILE 1961 -0.08 ASN 1746

ARG 1834 0.18 PHE 1962 -0.11 SER 1714

ARG 1834 0.16 GLY 1963 -0.12 SER 1714

ARG 1834 0.14 PHE 1964 -0.11 ARG 1793

ARG 1834 0.17 LEU 1965 -0.10 LYS 1795

ARG 1834 0.20 LYS 1966 -0.20 HIS 1967

ARG 1834 0.15 HIS 1967 -0.20 LYS 1966

ARG 1834 0.15 ILE 1968 -0.11 VAL 1731

ARG 1834 0.20 ARG 1969 -0.14 GLN 1732

ARG 1834 0.18 SER 1970 -0.18 GLY 1777

ARG 1834 0.13 GLN 1971 -0.17 GLN 1732

ASP 1737 0.22 ARG 1972 -0.14 GLN 1732

ASP 1737 0.40 ASN 1973 -0.20 ALA 1742

VAL 1736 0.40 TYR 1974 -0.19 ASN 1746

VAL 1736 0.23 LEU 1975 -0.16 ASN 1746

ARG 1834 0.23 VAL 1976 -0.16 ASN 1746

ARG 1834 0.31 GLN 1977 -0.23 ASN 1746

LYS 1832 0.38 THR 1978 -0.23 ASN 1746

LYS 1832 0.34 GLU 1979 -0.21 ASN 1746

LYS 1832 0.33 GLU 1980 -0.20 ASN 1758

GLN 1898 0.27 GLN 1981 -0.18 ASN 1758

LYS 1832 0.23 TYR 1982 -0.17 ASN 1746

GLN 1898 0.23 VAL 1983 -0.16 ASN 1746

GLN 1898 0.26 PHE 1984 -0.17 ASN 1758

TYR 1896 0.16 ILE 1985 -0.13 ASN 1758

GLN 1898 0.15 HIS 1986 -0.12 ASN 1746

TYR 1907 0.24 ASP 1987 -0.14 ASN 1758

VAL 1911 0.19 THR 1988 -0.13 ASN 1758

LYS 1775 0.14 LEU 1989 -0.10 ASN 1758

GLU 1991 0.13 VAL 1990 -0.10 ASN 1758

LYS 1775 0.15 GLU 1991 -0.14 MET 1902

LYS 1775 0.17 ALA 1992 -0.14 MET 1902

ARG 1923 0.16 ILE 1993 -0.12 MET 1902

ARG 1923 0.17 LEU 1994 -0.15 MET 1902

ARG 1923 0.24 SER 1995 -0.22 MET 1902

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: April 8th, 2025.

Should you encounter any unexpected behaviour, please let us know.

*** HYDROLASE/HYDROLASE INHIBITOR 04-OCT-16 5H08 ***

CA distance fluctuations for 2502261434124124660

--- normal mode 9 ---

Should you encounter any unexpected behaviour,
please let us know.

* HYDROLASE/HYDROLASE INHIBITOR 04-OCT-16 5H08 *