Should you encounter any unexpected behaviour,
please let us know.

* HYDROLASE/HYDROLASE INHIBITOR 04-OCT-16 5H08 *

CA distance fluctuations for 2502261434124124660

--- normal mode 7 ---

This matrix displays the maximum distance fluctuations between all pairs of CA atoms and between the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Distance increases are plotted in blue and decreases in red for the strongest 10% of the residue pair distance changes. Every pixel corresponds to a single residue. Grey lines are drawn every 10 residues, yellow lines every 100 residues (counting from the upper left corner).

The following table indicates for every residue the two corresponding residues with the strongest CA distance fluctuations.

[HELP on distance fluctuations]

GD ok

largest increase ref largest decrease
VAL 1736 0.08 GLY 1696 -0.15 ALA 1770

VAL 1736 0.07 PRO 1697 -0.17 ALA 1770

VAL 1736 0.06 ALA 1698 -0.19 ALA 1770

PRO 1900 0.07 ILE 1699 -0.17 ALA 1770

LEU 1909 0.08 PRO 1700 -0.18 ALA 1770

LEU 1909 0.10 ILE 1701 -0.16 ALA 1770

MET 1902 0.11 LYS 1702 -0.15 ALA 1770

MET 1902 0.11 HIS 1703 -0.14 ALA 1770

ASP 1776 0.10 PHE 1704 -0.13 ALA 1770

ASP 1776 0.14 PRO 1705 -0.11 ALA 1770

GLY 1903 0.14 LYS 1706 -0.10 ALA 1770

ASP 1776 0.12 HIS 1707 -0.11 ALA 1770

ASP 1776 0.16 VAL 1708 -0.09 ALA 1770

ASP 1776 0.18 ALA 1709 -0.07 ALA 1770

ASP 1776 0.16 ASP 1710 -0.08 ALA 1770

ASP 1776 0.18 LEU 1711 -0.07 ALA 1770

ASP 1776 0.22 HIS 1712 -0.05 ARG 1923

ASP 1776 0.21 ALA 1713 -0.06 ARG 1923

ASP 1776 0.18 SER 1714 -0.06 GLY 1963

ASP 1776 0.22 SER 1715 -0.04 TYR 1907

ASP 1776 0.18 GLY 1716 -0.05 ALA 1770

ASP 1776 0.20 PHE 1717 -0.06 TYR 1907

ASP 1776 0.23 THR 1718 -0.09 TYR 1907

ASP 1776 0.18 GLU 1719 -0.06 TYR 1907

ASP 1776 0.15 GLU 1720 -0.06 ALA 1770

ASP 1776 0.19 PHE 1721 -0.07 GLY 1903

ASP 1776 0.18 GLU 1722 -0.10 GLY 1903

PRO 1748 0.12 GLU 1730 -0.07 GLY 1903

ASP 1776 0.12 VAL 1731 -0.07 GLY 1903

ASP 1776 0.16 GLN 1732 -0.11 GLY 1903

PRO 1748 0.14 SER 1733 -0.11 MET 1902

VAL 1736 0.10 CYS 1734 -0.09 MET 1902

HIS 1967 0.10 THR 1735 -0.11 GLY 1777

HIS 1967 0.11 VAL 1736 -0.19 ASN 1758

PRO 1794 0.07 ASP 1737 -0.23 ASN 1758

PRO 1794 0.17 LEU 1738 -0.19 GLY 1777

HIS 1764 0.12 GLY 1739 -0.25 GLY 1777

HIS 1818 0.09 ILE 1740 -0.20 GLY 1777

SER 1733 0.08 THR 1741 -0.21 GLY 1777

GLN 1732 0.10 ALA 1742 -0.15 GLY 1777

GLU 1722 0.09 ASP 1743 -0.21 GLY 1777

GLN 1977 0.09 SER 1744 -0.18 GLY 1777

GLN 1977 0.13 SER 1745 -0.07 LYS 1753

GLN 1977 0.16 ASN 1746 -0.10 HIS 1752

THR 1978 0.14 HIS 1747 -0.09 GLY 1777

ASN 1758 0.20 PRO 1748 -0.13 GLY 1850

LYS 1778 0.19 ASP 1749 -0.13 GLY 1850

ASP 1776 0.27 ASN 1750 -0.10 GLY 1850

ASP 1776 0.37 LYS 1751 -0.12 GLY 1850

ASP 1776 0.59 HIS 1752 -0.13 GLY 1850

ASP 1776 0.48 LYS 1753 -0.11 GLU 1809

ASP 1776 0.44 ASN 1754 -0.10 ASP 1737

ASP 1776 0.52 ARG 1755 -0.14 ASP 1737

ASP 1776 0.44 TYR 1756 -0.17 ASP 1737

ASP 1776 0.38 ILE 1757 -0.16 ASP 1737

ASP 1776 0.30 ASN 1758 -0.23 ASP 1737

ASP 1776 0.29 ILE 1759 -0.20 ASP 1737

ASP 1776 0.20 VAL 1760 -0.15 ASP 1737

ASP 1776 0.12 ALA 1761 -0.09 ASP 1737

GLN 1732 0.07 TYR 1762 -0.14 GLY 1777

GLU 1817 0.09 ASP 1763 -0.25 GLY 1777

LEU 1738 0.12 HIS 1764 -0.29 GLY 1777

HIS 1818 0.12 SER 1765 -0.21 GLY 1777

GLU 1817 0.09 ARG 1766 -0.16 VAL 1788

GLU 1817 0.11 VAL 1767 -0.21 ALA 1770

GLU 1817 0.09 LYS 1768 -0.26 LYS 1795

SER 1806 0.07 LEU 1769 -0.25 ALA 1770

GLY 1850 0.13 ALA 1770 -0.35 HIS 1818

SER 1806 0.25 GLN 1771 -0.36 LEU 1772

GLY 1850 0.43 LEU 1772 -0.36 GLN 1771

SER 1806 0.58 ALA 1773 -0.30 PRO 1794

SER 1806 0.88 GLU 1774 -0.17 GLN 1771

LYS 1805 0.82 LYS 1775 -0.17 HIS 1764

SER 1806 0.84 ASP 1776 -0.12 HIS 1764

SER 1806 0.61 GLY 1777 -0.29 HIS 1764

SER 1806 0.38 LYS 1778 -0.17 PRO 1794

SER 1806 0.27 LEU 1779 -0.22 PRO 1794

SER 1806 0.27 THR 1780 -0.16 PRO 1794

SER 1806 0.11 ASP 1781 -0.22 LYS 1795

GLU 1774 0.11 TYR 1782 -0.14 LYS 1795

GLU 1774 0.22 ILE 1783 -0.11 LYS 1795

ASP 1776 0.25 ASN 1784 -0.07 ASP 1737

ASP 1776 0.18 ALA 1785 -0.10 ALA 1770

SER 1765 0.09 ASN 1786 -0.16 ALA 1770

LEU 1738 0.12 TYR 1787 -0.24 ALA 1770

LEU 1738 0.12 VAL 1788 -0.23 ALA 1770

LEU 1738 0.14 ASP 1789 -0.25 ALA 1770

LEU 1738 0.10 GLY 1790 -0.26 ALA 1770

LEU 1738 0.11 TYR 1791 -0.25 ALA 1770

ARG 1923 0.14 ASN 1792 -0.28 ALA 1770

LEU 1738 0.14 ARG 1793 -0.32 ALA 1770

LEU 1738 0.17 PRO 1794 -0.32 ALA 1770

LEU 1738 0.16 LYS 1795 -0.34 ALA 1770

LEU 1738 0.13 ALA 1796 -0.29 ALA 1770

LEU 1738 0.10 TYR 1797 -0.25 ALA 1770

ASP 1776 0.11 ILE 1798 -0.21 ALA 1770

ASP 1776 0.18 ALA 1799 -0.14 ALA 1770

ASP 1776 0.26 ALA 1800 -0.08 ALA 1770

ASP 1776 0.36 GLN 1801 -0.11 ASP 1737

ASP 1776 0.44 GLY 1802 -0.10 ASP 1737

GLU 1774 0.52 PRO 1803 -0.09 ASP 1737

ASP 1776 0.67 LEU 1804 -0.10 ASP 1737

GLU 1774 0.82 LYS 1805 -0.08 ASP 1737

GLU 1774 0.88 SER 1806 -0.09 TYR 1849

GLU 1774 0.66 THR 1807 -0.10 ALA 1808

GLU 1774 0.61 ALA 1808 -0.10 THR 1807

GLU 1774 0.60 GLU 1809 -0.11 LYS 1753

GLU 1774 0.44 ASP 1810 -0.09 LYS 1753

GLU 1774 0.38 PHE 1811 -0.07 ARG 1793

GLU 1774 0.34 TRP 1812 -0.07 ASP 1749

GLU 1774 0.24 ARG 1813 -0.10 HIS 1955

GLU 1774 0.15 MET 1814 -0.18 ALA 1770

GLU 1774 0.17 ILE 1815 -0.15 ALA 1770

LYS 1775 0.10 TRP 1816 -0.13 ALA 1770

VAL 1767 0.11 GLU 1817 -0.26 ALA 1770

SER 1765 0.12 HIS 1818 -0.35 ALA 1770

LEU 1738 0.12 ASN 1819 -0.26 ALA 1770

LEU 1738 0.10 VAL 1820 -0.21 ALA 1770

LYS 1775 0.13 GLU 1821 -0.15 ALA 1770

LYS 1775 0.17 VAL 1822 -0.15 ALA 1770

LYS 1775 0.24 ILE 1823 -0.12 ALA 1770

LYS 1775 0.26 VAL 1824 -0.11 ALA 1770

LYS 1775 0.35 MET 1825 -0.07 ALA 1770

LYS 1775 0.35 ILE 1826 -0.09 VAL 1736

LYS 1775 0.43 THR 1827 -0.11 VAL 1736

LYS 1775 0.50 ASN 1828 -0.11 VAL 1736

LYS 1775 0.58 LEU 1829 -0.11 VAL 1736

LYS 1775 0.59 VAL 1830 -0.13 VAL 1736

LYS 1775 0.53 GLU 1831 -0.14 VAL 1736

LYS 1775 0.54 LYS 1832 -0.16 VAL 1736

LYS 1775 0.62 GLY 1833 -0.15 VAL 1736

LYS 1775 0.60 ARG 1834 -0.16 VAL 1736

LYS 1775 0.64 ARG 1835 -0.14 VAL 1736

ASP 1776 0.55 LYS 1836 -0.14 VAL 1736

LYS 1775 0.57 CYS 1837 -0.11 ASP 1737

LYS 1775 0.67 ASP 1838 -0.10 ASP 1737

LYS 1775 0.64 GLN 1839 -0.08 ASP 1737

LYS 1775 0.59 TYR 1840 -0.07 ASP 1737

LYS 1775 0.54 TRP 1841 -0.06 LYS 1805

LYS 1775 0.58 PRO 1842 -0.08 LYS 1805

LYS 1775 0.60 ALA 1843 -0.07 LYS 1805

LYS 1775 0.55 ASP 1844 -0.06 LYS 1805

LYS 1775 0.50 GLY 1845 -0.06 LYS 1805

LYS 1775 0.52 SER 1846 -0.06 SER 1806

LYS 1775 0.60 GLU 1847 -0.08 SER 1806

LYS 1775 0.59 GLU 1848 -0.09 HIS 1752

GLU 1774 0.65 TYR 1849 -0.11 HIS 1752

GLU 1774 0.67 GLY 1850 -0.13 HIS 1752

GLU 1774 0.40 ASN 1851 -0.12 ASP 1749

GLU 1774 0.39 PHE 1852 -0.09 ASP 1749

LYS 1775 0.41 LEU 1853 -0.08 PRO 1748

LYS 1775 0.42 VAL 1854 -0.06 PRO 1748

LYS 1775 0.41 THR 1855 -0.05 PRO 1748

LYS 1775 0.42 GLN 1856 -0.05 LYS 1805

LYS 1775 0.35 LYS 1857 -0.04 LYS 1805

LYS 1775 0.35 SER 1858 -0.04 VAL 1904

LYS 1775 0.38 VAL 1859 -0.04 VAL 1904

LYS 1775 0.34 GLN 1860 -0.06 PRO 1905

LYS 1775 0.38 VAL 1861 -0.07 VAL 1904

LYS 1775 0.35 LEU 1862 -0.08 PRO 1905

LYS 1775 0.37 ALA 1863 -0.10 PRO 1905

LYS 1775 0.35 TYR 1864 -0.12 PRO 1905

LYS 1775 0.36 TYR 1865 -0.08 PRO 1905

LYS 1775 0.37 THR 1866 -0.06 VAL 1904

LYS 1775 0.33 VAL 1867 -0.06 ALA 1770

LYS 1775 0.36 ARG 1868 -0.04 ALA 1770

LYS 1775 0.31 ASN 1869 -0.05 ALA 1770

LYS 1775 0.33 PHE 1870 -0.04 ARG 1916

LYS 1775 0.28 THR 1871 -0.05 HIS 1955

LYS 1775 0.26 LEU 1872 -0.07 HIS 1955

LYS 1775 0.23 ARG 1873 -0.08 HIS 1955

LYS 1775 0.18 ASN 1874 -0.09 HIS 1955

LYS 1775 0.21 THR 1875 -0.10 ASP 1749

GLN 1771 0.14 LYS 1876 -0.11 ASP 1749

ALA 1770 0.09 ILE 1877 -0.11 HIS 1955

LYS 1775 0.14 ARG 1889 -0.09 HIS 1955

LYS 1775 0.19 VAL 1890 -0.08 SER 1995

LYS 1775 0.22 VAL 1891 -0.10 ALA 1770

LYS 1775 0.25 THR 1892 -0.09 ALA 1770

LYS 1775 0.30 GLN 1893 -0.08 ALA 1770

LYS 1775 0.30 TYR 1894 -0.08 ALA 1770

LYS 1775 0.37 HIS 1895 -0.06 VAL 1736

LYS 1775 0.36 TYR 1896 -0.07 VAL 1736

LYS 1775 0.42 THR 1897 -0.09 VAL 1736

LYS 1775 0.40 GLN 1898 -0.10 VAL 1904

LYS 1775 0.42 TRP 1899 -0.12 VAL 1736

LYS 1775 0.42 PRO 1900 -0.12 VAL 1736

LYS 1775 0.46 ASP 1901 -0.14 VAL 1736

LYS 1775 0.42 MET 1902 -0.15 VAL 1736

LYS 1775 0.39 GLY 1903 -0.15 VAL 1736

ASP 1776 0.37 VAL 1904 -0.14 THR 1978

ASP 1776 0.35 PRO 1905 -0.12 TYR 1864

ASP 1776 0.30 GLU 1906 -0.15 GLU 1980

LYS 1775 0.30 TYR 1907 -0.12 GLU 1980

ASP 1776 0.25 SER 1908 -0.08 GLU 1980

LYS 1775 0.24 LEU 1909 -0.08 ALA 1770

LYS 1775 0.26 PRO 1910 -0.09 GLU 1980

LYS 1775 0.26 VAL 1911 -0.08 GLU 1980

ASP 1776 0.21 LEU 1912 -0.11 ALA 1770

LYS 1775 0.21 THR 1913 -0.11 ALA 1770

LYS 1775 0.24 PHE 1914 -0.10 ALA 1770

ASP 1776 0.19 VAL 1915 -0.13 ALA 1770

ASP 1776 0.15 ARG 1916 -0.14 ALA 1770

LYS 1775 0.18 LYS 1917 -0.13 ALA 1770

LYS 1775 0.17 ALA 1918 -0.14 ALA 1770

ASN 1792 0.13 ALA 1919 -0.16 ALA 1770

ASN 1792 0.14 TYR 1920 -0.16 ALA 1770

LYS 1775 0.13 ALA 1921 -0.16 ALA 1770

LEU 1738 0.09 LYS 1922 -0.19 ALA 1770

ASN 1792 0.14 ARG 1923 -0.19 ALA 1770

LEU 1738 0.12 HIS 1924 -0.20 ALA 1770

LEU 1738 0.11 ALA 1925 -0.22 ALA 1770

LEU 1738 0.13 VAL 1926 -0.27 ALA 1770

LEU 1738 0.13 GLY 1927 -0.29 ALA 1770

LEU 1738 0.12 PRO 1928 -0.27 ALA 1770

ASP 1776 0.11 VAL 1929 -0.21 ALA 1770

ASP 1776 0.18 VAL 1930 -0.17 ALA 1770

ASP 1776 0.23 VAL 1931 -0.13 ALA 1770

ASP 1776 0.31 HIS 1932 -0.08 ASP 1737

ASP 1776 0.37 CYS 1933 -0.11 ASP 1737

ASP 1776 0.44 SER 1934 -0.14 ASP 1737

ASP 1776 0.39 ALA 1935 -0.15 ASP 1737

ASP 1776 0.32 GLY 1936 -0.11 ASP 1737

ASP 1776 0.28 VAL 1937 -0.12 VAL 1736

ASP 1776 0.30 GLY 1938 -0.13 VAL 1736

ASP 1776 0.30 ARG 1939 -0.10 VAL 1736

ASP 1776 0.26 THR 1940 -0.09 ALA 1770

ASP 1776 0.21 GLY 1941 -0.10 ALA 1770

ASP 1776 0.23 THR 1942 -0.09 ALA 1770

ASP 1776 0.21 TYR 1943 -0.12 ALA 1770

ASP 1776 0.14 ILE 1944 -0.16 ALA 1770

ASP 1776 0.13 VAL 1945 -0.15 ALA 1770

ASP 1776 0.15 LEU 1946 -0.14 ALA 1770

ASP 1776 0.12 ASP 1947 -0.17 ALA 1770

LEU 1738 0.08 SER 1948 -0.21 ALA 1770

ASP 1776 0.08 MET 1949 -0.18 ALA 1770

LEU 1912 0.10 LEU 1950 -0.18 ALA 1770

ARG 1916 0.12 GLN 1951 -0.23 ALA 1770

ARG 1916 0.08 GLN 1952 -0.22 ALA 1770

LEU 1909 0.09 ILE 1953 -0.20 ALA 1770

THR 1913 0.11 GLN 1954 -0.21 ALA 1770

ARG 1916 0.09 HIS 1955 -0.24 ALA 1770

LEU 1909 0.08 GLU 1956 -0.22 ALA 1770

LEU 1909 0.10 GLY 1957 -0.20 ALA 1770

LEU 1909 0.08 THR 1958 -0.19 ALA 1770

LEU 1909 0.07 VAL 1959 -0.18 ALA 1770

GLU 1956 0.06 ASN 1960 -0.17 ALA 1770

ASP 1776 0.09 ILE 1961 -0.14 ALA 1770

ASP 1776 0.09 PHE 1962 -0.12 ALA 1770

VAL 1736 0.07 GLY 1963 -0.15 ALA 1770

LEU 1738 0.07 PHE 1964 -0.17 ALA 1770

ASP 1776 0.09 LEU 1965 -0.13 ALA 1770

CYS 1734 0.06 LYS 1966 -0.12 ALA 1770

LEU 1738 0.13 HIS 1967 -0.16 GLN 1771

LEU 1738 0.10 ILE 1968 -0.16 ALA 1770

ASP 1776 0.09 ARG 1969 -0.10 ALA 1770

LEU 1738 0.13 SER 1970 -0.14 GLY 1777

LEU 1738 0.12 GLN 1971 -0.15 GLN 1771

ASP 1776 0.11 ARG 1972 -0.10 ALA 1770

ASP 1776 0.16 ASN 1973 -0.17 ASP 1737

ASP 1776 0.21 TYR 1974 -0.17 VAL 1736

ASP 1776 0.20 LEU 1975 -0.10 VAL 1736

ASP 1776 0.24 VAL 1976 -0.10 VAL 1736

ASP 1776 0.30 GLN 1977 -0.15 VAL 1736

ASP 1776 0.30 THR 1978 -0.14 GLY 1903

ASP 1776 0.28 GLU 1979 -0.10 GLU 1906

ASP 1776 0.31 GLU 1980 -0.15 GLU 1906

ASP 1776 0.28 GLN 1981 -0.10 GLU 1906

ASP 1776 0.23 TYR 1982 -0.07 TYR 1907

ASP 1776 0.24 VAL 1983 -0.07 TYR 1907

ASP 1776 0.26 PHE 1984 -0.08 TYR 1907

ASP 1776 0.21 ILE 1985 -0.09 ALA 1770

ASP 1776 0.18 HIS 1986 -0.10 ALA 1770

ASP 1776 0.22 ASP 1987 -0.08 ALA 1770

ASP 1776 0.22 THR 1988 -0.09 ALA 1770

ASP 1776 0.16 LEU 1989 -0.12 ALA 1770

ASP 1776 0.16 VAL 1990 -0.11 ALA 1770

ASP 1776 0.18 GLU 1991 -0.11 ARG 1923

ASP 1776 0.16 ALA 1992 -0.14 ARG 1923

LEU 1909 0.15 ILE 1993 -0.15 ARG 1923

MET 1902 0.15 LEU 1994 -0.14 ARG 1923

LEU 1909 0.21 SER 1995 -0.17 ARG 1923

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: April 8th, 2025.

Should you encounter any unexpected behaviour, please let us know.

*** HYDROLASE/HYDROLASE INHIBITOR 04-OCT-16 5H08 ***

CA distance fluctuations for 2502261434124124660

--- normal mode 7 ---

Should you encounter any unexpected behaviour,
please let us know.

* HYDROLASE/HYDROLASE INHIBITOR 04-OCT-16 5H08 *