Should you encounter any unexpected behaviour,
please let us know.

* HYDROLASE/HYDROLASE INHIBITOR 04-OCT-16 5H08 *

CA distance fluctuations for 2502261434124124660

--- normal mode 11 ---

This matrix displays the maximum distance fluctuations between all pairs of CA atoms and between the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Distance increases are plotted in blue and decreases in red for the strongest 10% of the residue pair distance changes. Every pixel corresponds to a single residue. Grey lines are drawn every 10 residues, yellow lines every 100 residues (counting from the upper left corner).

The following table indicates for every residue the two corresponding residues with the strongest CA distance fluctuations.

[HELP on distance fluctuations]

GD ok

largest increase ref largest decrease
LEU 1738 0.28 GLY 1696 -0.14 ALA 1770

LEU 1738 0.26 PRO 1697 -0.13 ALA 1770

LEU 1738 0.28 ALA 1698 -0.11 ALA 1770

LEU 1738 0.22 ILE 1699 -0.10 ALA 1770

LEU 1738 0.22 PRO 1700 -0.12 PRO 1900

LEU 1738 0.18 ILE 1701 -0.17 PRO 1900

LEU 1738 0.16 LYS 1702 -0.17 MET 1902

LEU 1738 0.15 HIS 1703 -0.11 PRO 1900

LEU 1738 0.14 PHE 1704 -0.11 PRO 1900

GLN 1860 0.13 PRO 1705 -0.14 MET 1902

GLN 1860 0.13 LYS 1706 -0.08 ARG 1834

TYR 1907 0.13 HIS 1707 -0.09 ALA 1770

TYR 1907 0.19 VAL 1708 -0.08 ALA 1770

TYR 1907 0.26 ALA 1709 -0.07 ARG 1834

TYR 1907 0.24 ASP 1710 -0.10 GLY 1696

TYR 1907 0.26 LEU 1711 -0.10 GLY 1696

TYR 1907 0.34 HIS 1712 -0.11 VAL 1736

TYR 1907 0.31 ALA 1713 -0.11 VAL 1736

TYR 1907 0.28 SER 1714 -0.13 GLY 1696

TYR 1907 0.32 SER 1715 -0.14 GLU 1719

GLY 1903 0.24 GLY 1716 -0.14 GLU 1720

GLY 1903 0.26 PHE 1717 -0.11 VAL 1736

GLY 1903 0.36 THR 1718 -0.15 VAL 1736

MET 1902 0.32 GLU 1719 -0.15 VAL 1736

GLY 1903 0.25 GLU 1720 -0.14 GLY 1716

GLY 1903 0.30 PHE 1721 -0.12 ALA 1770

MET 1902 0.36 GLU 1722 -0.20 VAL 1736

MET 1902 0.29 GLU 1730 -0.14 ALA 1770

MET 1902 0.27 VAL 1731 -0.15 ALA 1770

MET 1902 0.33 GLN 1732 -0.20 VAL 1736

MET 1902 0.31 SER 1733 -0.24 VAL 1736

MET 1902 0.27 CYS 1734 -0.17 ALA 1770

MET 1902 0.25 THR 1735 -0.18 ALA 1770

MET 1902 0.22 VAL 1736 -0.24 SER 1733

MET 1902 0.19 ASP 1737 -0.16 GLN 1732

HIS 1967 0.34 LEU 1738 -0.18 ALA 1770

ASN 1792 0.31 GLY 1739 -0.21 ALA 1770

ASN 1792 0.23 ILE 1740 -0.20 ALA 1770

GLY 1777 0.22 THR 1741 -0.19 GLY 1850

TYR 1762 0.21 ALA 1742 -0.23 GLY 1850

GLY 1777 0.28 ASP 1743 -0.27 GLY 1850

GLY 1777 0.23 SER 1744 -0.29 GLY 1850

MET 1902 0.23 SER 1745 -0.29 GLY 1850

MET 1902 0.28 ASN 1746 -0.35 GLY 1850

ASP 1776 0.25 HIS 1747 -0.44 GLY 1850

ASN 1758 0.30 PRO 1748 -0.53 GLY 1850

GLU 1774 0.29 ASP 1749 -0.67 GLY 1850

GLU 1774 0.27 ASN 1750 -0.48 GLY 1850

GLU 1774 0.33 LYS 1751 -0.42 GLY 1850

GLU 1774 0.35 HIS 1752 -0.37 GLY 1850

LEU 1772 0.32 LYS 1753 -0.33 TYR 1849

MET 1902 0.24 ASN 1754 -0.23 TYR 1849

ARG 1834 0.30 ARG 1755 -0.15 TYR 1849

MET 1902 0.34 TYR 1756 -0.15 TYR 1849

MET 1902 0.34 ILE 1757 -0.19 GLY 1850

MET 1902 0.36 ASN 1758 -0.16 THR 1741

MET 1902 0.31 ILE 1759 -0.14 GLY 1850

MET 1902 0.26 VAL 1760 -0.18 GLY 1850

MET 1902 0.21 ALA 1761 -0.17 GLY 1850

ALA 1742 0.21 TYR 1762 -0.19 ALA 1770

PRO 1794 0.19 ASP 1763 -0.24 ALA 1770

PRO 1794 0.24 HIS 1764 -0.29 ALA 1770

LYS 1795 0.21 SER 1765 -0.28 ALA 1770

MET 1902 0.14 ARG 1766 -0.23 ALA 1770

ARG 1834 0.12 VAL 1767 -0.26 ALA 1770

ARG 1834 0.13 LYS 1768 -0.29 ALA 1770

THR 1807 0.18 LEU 1769 -0.24 ASP 1776

SER 1806 0.31 ALA 1770 -0.29 HIS 1764

SER 1806 0.34 GLN 1771 -0.21 HIS 1764

SER 1806 0.48 LEU 1772 -0.45 ILE 1877

SER 1806 0.37 ALA 1773 -0.63 ILE 1877

HIS 1752 0.35 GLU 1774 -1.33 LYS 1876

LYS 1751 0.28 LYS 1775 -1.35 LYS 1876

PRO 1748 0.26 ASP 1776 -1.30 ASN 1851

ASP 1743 0.28 GLY 1777 -0.96 GLY 1850

ASP 1743 0.24 LYS 1778 -0.92 GLY 1850

SER 1744 0.18 LEU 1779 -0.64 GLY 1850

LYS 1753 0.31 THR 1780 -0.48 ASN 1851

ARG 1834 0.18 ASP 1781 -0.21 ASN 1851

ARG 1834 0.17 TYR 1782 -0.28 GLY 1850

ARG 1834 0.17 ILE 1783 -0.26 GLU 1809

MET 1902 0.18 ASN 1784 -0.20 GLU 1809

MET 1902 0.15 ALA 1785 -0.13 ASP 1776

MET 1902 0.14 ASN 1786 -0.19 ALA 1770

SER 1765 0.15 TYR 1787 -0.22 ALA 1770

GLY 1739 0.17 VAL 1788 -0.19 ALA 1770

GLY 1739 0.25 ASP 1789 -0.19 ALA 1770

GLY 1739 0.24 GLY 1790 -0.14 ALA 1770

GLY 1739 0.29 TYR 1791 -0.14 ARG 1916

GLY 1739 0.31 ASN 1792 -0.14 ARG 1916

GLY 1739 0.27 ARG 1793 -0.16 ALA 1770

GLY 1739 0.28 PRO 1794 -0.20 ALA 1770

SER 1765 0.21 LYS 1795 -0.22 ALA 1770

GLY 1739 0.17 ALA 1796 -0.20 GLU 1774

GLY 1739 0.12 TYR 1797 -0.20 ASP 1776

VAL 1904 0.09 ILE 1798 -0.21 ASP 1776

GLY 1903 0.12 ALA 1799 -0.16 ASP 1776

MET 1902 0.13 ALA 1800 -0.17 ASP 1776

MET 1902 0.18 GLN 1801 -0.14 ASP 1776

LEU 1772 0.15 GLY 1802 -0.22 ASP 1776

LEU 1772 0.22 PRO 1803 -0.30 ASP 1776

LEU 1772 0.32 LEU 1804 -0.26 ASP 1776

LEU 1772 0.37 LYS 1805 -0.38 ASP 1776

LEU 1772 0.48 SER 1806 -0.39 TYR 1849

LEU 1772 0.37 THR 1807 -0.44 ALA 1808

ASP 1838 0.19 ALA 1808 -0.57 ASP 1776

ALA 1770 0.20 GLU 1809 -0.75 ASP 1776

ALA 1770 0.27 ASP 1810 -0.55 ASP 1776

PRO 1803 0.14 PHE 1811 -0.48 ASP 1776

ARG 1835 0.12 TRP 1812 -0.64 ASP 1776

ALA 1770 0.15 ARG 1813 -0.63 ASP 1776

ARG 1835 0.12 MET 1814 -0.46 ASP 1776

ARG 1835 0.09 ILE 1815 -0.50 ASP 1776

LYS 1876 0.11 TRP 1816 -0.60 ASP 1776

LYS 1876 0.13 GLU 1817 -0.52 GLU 1774

LYS 1876 0.11 HIS 1818 -0.40 GLU 1774

LYS 1876 0.13 ASN 1819 -0.46 GLU 1774

SER 1995 0.12 VAL 1820 -0.43 ASP 1776

SER 1995 0.14 GLU 1821 -0.46 ASP 1776

SER 1995 0.13 VAL 1822 -0.41 ASP 1776

VAL 1904 0.10 ILE 1823 -0.38 ASP 1776

VAL 1904 0.11 VAL 1824 -0.31 ASP 1776

VAL 1904 0.12 MET 1825 -0.29 ASP 1776

VAL 1904 0.15 ILE 1826 -0.21 ASP 1776

VAL 1904 0.12 THR 1827 -0.19 ASP 1776

LEU 1772 0.11 ASN 1828 -0.21 ASP 1776

LEU 1772 0.17 LEU 1829 -0.23 ASP 1776

LEU 1772 0.20 VAL 1830 -0.20 TYR 1907

TYR 1756 0.22 GLU 1831 -0.28 TYR 1907

TYR 1756 0.32 LYS 1832 -0.30 TYR 1907

TYR 1756 0.27 GLY 1833 -0.26 TYR 1907

ARG 1755 0.30 ARG 1834 -0.25 TYR 1907

LEU 1772 0.29 ARG 1835 -0.20 TYR 1907

LEU 1772 0.23 LYS 1836 -0.18 TYR 1907

LEU 1772 0.22 CYS 1837 -0.20 ASP 1776

LEU 1772 0.24 ASP 1838 -0.30 ASP 1776

LEU 1772 0.16 GLN 1839 -0.42 ASP 1776

ALA 1770 0.12 TYR 1840 -0.55 ASP 1776

ALA 1770 0.08 TRP 1841 -0.62 ASP 1776

LYS 1917 0.10 PRO 1842 -0.70 ASP 1776

VAL 1861 0.12 ALA 1843 -0.61 ASP 1776

VAL 1861 0.16 ASP 1844 -0.67 ASP 1776

LYS 1917 0.15 GLY 1845 -0.76 ASP 1776

LYS 1917 0.13 SER 1846 -0.86 ASP 1776

LYS 1917 0.10 GLU 1847 -0.93 ASP 1776

ALA 1770 0.10 GLU 1848 -1.10 ASP 1776

ALA 1770 0.13 TYR 1849 -1.02 ASP 1776

ALA 1770 0.16 GLY 1850 -1.27 ASP 1776

ALA 1770 0.14 ASN 1851 -1.30 ASP 1776

SER 1995 0.08 PHE 1852 -1.06 ASP 1776

LYS 1917 0.10 LEU 1853 -1.02 ASP 1776

LYS 1917 0.12 VAL 1854 -0.86 ASP 1776

LYS 1917 0.15 THR 1855 -0.80 ASP 1776

LYS 1917 0.17 GLN 1856 -0.68 ASP 1776

LYS 1917 0.20 LYS 1857 -0.65 ASP 1776

LYS 1917 0.21 SER 1858 -0.57 ASP 1776

THR 1913 0.18 VAL 1859 -0.50 ASP 1776

THR 1913 0.21 GLN 1860 -0.43 ASP 1776

SER 1715 0.18 VAL 1861 -0.38 ASP 1776

HIS 1712 0.22 LEU 1862 -0.32 ASP 1776

PRO 1905 0.25 ALA 1863 -0.27 MET 1902

PRO 1905 0.29 TYR 1864 -0.27 MET 1902

PRO 1905 0.22 TYR 1865 -0.29 ASP 1776

PRO 1905 0.17 THR 1866 -0.36 ASP 1776

PHE 1914 0.18 VAL 1867 -0.42 ASP 1776

LYS 1917 0.18 ARG 1868 -0.50 ASP 1776

LYS 1917 0.22 ASN 1869 -0.56 ASP 1776

LYS 1917 0.17 PHE 1870 -0.65 ASP 1776

LYS 1917 0.15 THR 1871 -0.73 ASP 1776

SER 1995 0.13 LEU 1872 -0.78 ASP 1776

SER 1995 0.13 ARG 1873 -0.92 ASP 1776

SER 1995 0.12 ASN 1874 -1.02 ASP 1776

SER 1995 0.11 THR 1875 -1.20 ASP 1776

GLU 1817 0.13 LYS 1876 -1.35 LYS 1775

SER 1995 0.14 ILE 1877 -1.16 LYS 1775

SER 1995 0.17 ARG 1889 -0.66 ASP 1776

SER 1995 0.17 VAL 1890 -0.60 ASP 1776

SER 1995 0.14 VAL 1891 -0.55 ASP 1776

ARG 1916 0.17 THR 1892 -0.48 ASP 1776

THR 1988 0.11 GLN 1893 -0.43 ASP 1776

GLN 1981 0.14 TYR 1894 -0.36 ASP 1776

GLN 1981 0.15 HIS 1895 -0.32 ASP 1776

PRO 1905 0.21 TYR 1896 -0.26 ASP 1776

PRO 1905 0.20 THR 1897 -0.24 ASP 1776

PRO 1905 0.32 GLN 1898 -0.29 ASP 1901

THR 1978 0.21 TRP 1899 -0.39 TYR 1907

THR 1978 0.23 PRO 1900 -0.51 TYR 1907

THR 1978 0.27 ASP 1901 -0.42 TYR 1907

THR 1978 0.42 MET 1902 -0.49 SER 1995

THR 1978 0.44 GLY 1903 -0.41 SER 1995

GLU 1980 0.40 VAL 1904 -0.29 SER 1995

GLN 1898 0.32 PRO 1905 -0.28 SER 1995

TYR 1864 0.26 GLU 1906 -0.35 SER 1995

HIS 1712 0.34 TYR 1907 -0.51 PRO 1900

HIS 1712 0.26 SER 1908 -0.37 MET 1902

HIS 1712 0.23 LEU 1909 -0.41 SER 1995

HIS 1712 0.22 PRO 1910 -0.34 MET 1902

PHE 1984 0.20 VAL 1911 -0.32 TRP 1899

THR 1988 0.22 LEU 1912 -0.27 GLN 1954

THR 1988 0.21 THR 1913 -0.27 GLN 1954

THR 1988 0.20 PHE 1914 -0.24 ASP 1776

THR 1988 0.20 VAL 1915 -0.22 ASP 1776

ASN 1869 0.21 ARG 1916 -0.29 GLN 1954

ASN 1869 0.22 LYS 1917 -0.27 ASP 1776

ASN 1869 0.18 ALA 1918 -0.29 ASP 1776

SER 1995 0.22 ALA 1919 -0.26 ASP 1776

SER 1995 0.28 TYR 1920 -0.29 ASP 1776

SER 1995 0.21 ALA 1921 -0.34 ASP 1776

SER 1995 0.21 LYS 1922 -0.32 ASP 1776

SER 1995 0.29 ARG 1923 -0.28 ASP 1776

SER 1995 0.28 HIS 1924 -0.32 ASP 1776

SER 1995 0.21 ALA 1925 -0.35 ASP 1776

SER 1995 0.20 VAL 1926 -0.35 GLU 1774

SER 1995 0.15 GLY 1927 -0.35 GLU 1774

SER 1995 0.13 PRO 1928 -0.28 ASP 1776

SER 1995 0.11 VAL 1929 -0.30 ASP 1776

VAL 1904 0.09 VAL 1930 -0.30 ASP 1776

VAL 1904 0.10 VAL 1931 -0.24 ASP 1776

VAL 1904 0.11 HIS 1932 -0.22 ASP 1776

GLY 1903 0.13 CYS 1933 -0.16 ASP 1776

MET 1902 0.20 SER 1934 -0.12 TYR 1907

MET 1902 0.27 ALA 1935 -0.08 ASP 1737

MET 1902 0.19 GLY 1936 -0.11 ASP 1776

MET 1902 0.23 VAL 1937 -0.07 GLU 1809

GLY 1903 0.26 GLY 1938 -0.07 GLU 1991

VAL 1904 0.19 ARG 1939 -0.11 LEU 1946

VAL 1904 0.14 THR 1940 -0.13 ASP 1776

VAL 1904 0.16 GLY 1941 -0.09 ASP 1776

VAL 1904 0.15 THR 1942 -0.10 ASP 1776

THR 1942 0.15 TYR 1943 -0.15 ASP 1776

LEU 1738 0.14 ILE 1944 -0.14 ASP 1776

LEU 1738 0.16 VAL 1945 -0.10 ALA 1770

ALA 1919 0.14 LEU 1946 -0.14 PRO 1900

LEU 1738 0.15 ASP 1947 -0.17 ASP 1776

LEU 1738 0.20 SER 1948 -0.13 ASP 1776

LEU 1738 0.19 MET 1949 -0.13 PRO 1900

SER 1995 0.21 LEU 1950 -0.22 LEU 1912

SER 1995 0.22 GLN 1951 -0.27 ARG 1916

LEU 1738 0.25 GLN 1952 -0.18 ARG 1916

SER 1995 0.22 ILE 1953 -0.20 LEU 1912

SER 1995 0.26 GLN 1954 -0.29 ARG 1916

GLY 1739 0.26 HIS 1955 -0.27 ARG 1916

GLY 1739 0.27 GLU 1956 -0.19 ARG 1916

LEU 1738 0.23 GLY 1957 -0.18 LEU 1909

LEU 1738 0.25 THR 1958 -0.13 PRO 1900

LEU 1738 0.22 VAL 1959 -0.10 PRO 1900

LEU 1738 0.25 ASN 1960 -0.12 ALA 1770

LEU 1738 0.18 ILE 1961 -0.12 ALA 1770

LEU 1738 0.18 PHE 1962 -0.13 ALA 1770

LEU 1738 0.28 GLY 1963 -0.15 ALA 1770

LEU 1738 0.27 PHE 1964 -0.15 ALA 1770

LEU 1738 0.19 LEU 1965 -0.15 ALA 1770

LEU 1738 0.25 LYS 1966 -0.17 HIS 1967

LEU 1738 0.34 HIS 1967 -0.19 ALA 1770

LEU 1738 0.24 ILE 1968 -0.19 ALA 1770

MET 1902 0.21 ARG 1969 -0.17 ALA 1770

LEU 1738 0.25 SER 1970 -0.21 ALA 1770

ALA 1742 0.19 GLN 1971 -0.22 ALA 1770

ASN 1746 0.20 ARG 1972 -0.16 ALA 1770

MET 1902 0.26 ASN 1973 -0.12 ALA 1770

MET 1902 0.29 TYR 1974 -0.11 ASP 1737

MET 1902 0.22 LEU 1975 -0.11 ALA 1770

GLY 1903 0.24 VAL 1976 -0.08 ALA 1770

MET 1902 0.36 GLN 1977 -0.10 ASP 1737

GLY 1903 0.44 THR 1978 -0.11 ASP 1737

GLY 1903 0.38 GLU 1979 -0.09 ASP 1737

VAL 1904 0.40 GLU 1980 -0.10 SER 1995

VAL 1904 0.30 GLN 1981 -0.08 VAL 1983

VAL 1904 0.23 TYR 1982 -0.08 ALA 1770

TYR 1907 0.22 VAL 1983 -0.09 ARG 1835

TYR 1907 0.25 PHE 1984 -0.12 SER 1995

VAL 1915 0.16 ILE 1985 -0.09 ARG 1834

TYR 1907 0.16 HIS 1986 -0.09 ARG 1834

SER 1908 0.24 ASP 1987 -0.13 ARG 1834

LEU 1912 0.22 THR 1988 -0.27 GLU 1906

ALA 1919 0.17 LEU 1989 -0.20 GLU 1906

TYR 1920 0.16 VAL 1990 -0.21 MET 1902

TYR 1920 0.18 GLU 1991 -0.34 MET 1902

TYR 1920 0.22 ALA 1992 -0.32 MET 1902

ARG 1923 0.22 ILE 1993 -0.30 MET 1902

TYR 1920 0.23 LEU 1994 -0.38 MET 1902

ARG 1923 0.29 SER 1995 -0.49 MET 1902

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: April 8th, 2025.

Should you encounter any unexpected behaviour, please let us know.

*** HYDROLASE/HYDROLASE INHIBITOR 04-OCT-16 5H08 ***

CA distance fluctuations for 2502261434124124660

--- normal mode 11 ---

Should you encounter any unexpected behaviour,
please let us know.

* HYDROLASE/HYDROLASE INHIBITOR 04-OCT-16 5H08 *