Should you encounter any unexpected behaviour,
please let us know.

* LYASE 16-Jul-19 6KHP *

CA strain for 2502122039304104175

--- normal mode 11 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
THR 21 PHE 22 -0.0001

PHE 22 GLN 23 0.0000

GLN 23 PRO 24 -0.0001

PRO 24 LEU 25 -0.0004

LEU 25 ASN 26 -0.0001

ASN 26 ALA 27 -0.0002

ALA 27 ASP 28 0.0003

ASP 28 ASP 29 0.0002

ASP 29 VAL 30 -0.0001

VAL 30 ARG 31 0.0483

ARG 31 SER 32 -0.0000

SER 32 TYR 33 0.0000

TYR 33 LEU 34 0.0002

LEU 34 HIS 35 0.0002

HIS 35 LYS 36 -0.0000

LYS 36 ALA 37 -0.0002

ALA 37 VAL 38 0.0002

VAL 38 ASP 39 0.0002

ASP 39 PHE 40 -0.0000

PHE 40 ILE 41 -0.0323

ILE 41 SER 42 0.0001

SER 42 ASP 43 -0.0000

ASP 43 TYR 44 0.0001

TYR 44 TYR 45 -0.0003

TYR 45 LYS 46 0.0004

LYS 46 SER 47 0.0001

SER 47 VAL 48 -0.0002

VAL 48 GLU 49 -0.0000

GLU 49 SER 50 -0.0002

SER 50 MET 51 -0.0363

MET 51 PRO 52 -0.0003

PRO 52 VAL 53 -0.0001

VAL 53 LEU 54 -0.0000

LEU 54 PRO 55 0.0003

PRO 55 ASN 56 -0.0000

ASN 56 VAL 57 0.0001

VAL 57 LYS 58 -0.0003

LYS 58 PRO 59 -0.0003

PRO 59 GLY 60 0.0002

GLY 60 TYR 61 0.0388

TYR 61 LEU 62 -0.0002

LEU 62 GLN 63 -0.0002

GLN 63 ASP 64 -0.0000

ASP 64 GLU 65 -0.0001

GLU 65 LEU 66 -0.0000

LEU 66 ARG 67 -0.0003

ARG 67 ALA 68 0.0002

ALA 68 SER 69 0.0001

SER 69 PRO 70 -0.0002

PRO 70 PRO 71 0.1350

PRO 71 THR 72 0.0004

THR 72 TYR 73 0.0002

TYR 73 SER 74 -0.0003

SER 74 ALA 75 -0.0000

ALA 75 PRO 76 0.0002

PRO 76 PHE 77 -0.0002

PHE 77 ASP 78 0.0002

ASP 78 VAL 79 0.0004

VAL 79 THR 80 -0.0002

THR 80 MET 81 0.0285

MET 81 LYS 82 0.0000

LYS 82 GLU 83 0.0002

GLU 83 LEU 84 -0.0001

LEU 84 ARG 85 -0.0002

ARG 85 SER 86 0.0003

SER 86 SER 87 -0.0002

SER 87 VAL 88 -0.0004

VAL 88 VAL 89 0.0002

VAL 89 PRO 90 -0.0001

PRO 90 GLY 91 0.0615

GLY 91 MET 92 0.0003

MET 92 THR 93 -0.0000

THR 93 HIS 94 0.0001

HIS 94 TRP 95 -0.0001

TRP 95 ALA 96 -0.0001

ALA 96 SER 97 -0.0000

SER 97 PRO 98 -0.0004

PRO 98 ASN 99 -0.0000

ASN 99 PHE 100 -0.0003

PHE 100 PHE 101 -0.0052

PHE 101 ALA 102 0.0002

ALA 102 PHE 103 -0.0003

PHE 103 PHE 104 0.0001

PHE 104 PRO 105 -0.0001

PRO 105 SER 106 0.0002

SER 106 THR 107 0.0002

THR 107 ASN 108 -0.0000

ASN 108 SER 109 -0.0001

SER 109 ALA 110 0.0003

ALA 110 ALA 111 0.0357

ALA 111 ALA 112 0.0003

ALA 112 ILE 113 -0.0003

ILE 113 ALA 114 0.0004

ALA 114 GLY 115 -0.0001

GLY 115 ASP 116 -0.0002

ASP 116 LEU 117 0.0002

LEU 117 ILE 118 0.0003

ILE 118 ALA 119 -0.0003

ALA 119 SER 120 -0.0003

SER 120 ALA 121 0.0025

ALA 121 MET 122 0.0004

MET 122 ASN 123 -0.0003

ASN 123 THR 124 0.0001

THR 124 VAL 125 0.0005

VAL 125 GLY 126 -0.0003

GLY 126 PHE 127 -0.0000

PHE 127 THR 128 0.0002

THR 128 TRP 129 -0.0002

TRP 129 GLN 130 -0.0002

GLN 130 ALA 131 -0.0014

ALA 131 SER 132 -0.0002

SER 132 PRO 133 -0.0000

PRO 133 ALA 134 0.0001

ALA 134 ALA 135 0.0004

ALA 135 THR 136 -0.0003

THR 136 GLU 137 -0.0001

GLU 137 MET 138 -0.0000

MET 138 GLU 139 -0.0001

GLU 139 VAL 140 0.0002

VAL 140 LEU 141 0.0149

LEU 141 ALA 142 0.0000

ALA 142 LEU 143 -0.0002

LEU 143 ASP 144 0.0002

ASP 144 TRP 145 -0.0001

TRP 145 LEU 146 -0.0001

LEU 146 ALA 147 -0.0001

ALA 147 GLN 148 0.0002

GLN 148 MET 149 -0.0001

MET 149 LEU 150 0.0001

LEU 150 ASN 151 0.0026

ASN 151 LEU 152 -0.0001

LEU 152 PRO 153 -0.0002

PRO 153 THR 154 0.0001

THR 154 SER 155 -0.0003

SER 155 PHE 156 -0.0001

PHE 156 MET 157 0.0002

MET 157 ASN 158 -0.0003

ASN 158 GLY 163 0.0013

GLY 163 ARG 164 -0.0002

ARG 164 GLY 165 -0.0002

GLY 165 THR 166 -0.0002

THR 166 GLY 167 0.0003

GLY 167 GLY 168 -0.0000

GLY 168 GLY 169 -0.0004

GLY 169 VAL 170 0.0004

VAL 170 ILE 171 -0.0001

ILE 171 LEU 172 0.0001

LEU 172 GLY 173 0.0094

GLY 173 THR 174 0.0002

THR 174 THR 175 -0.0003

THR 175 SER 176 -0.0002

SER 176 GLU 177 0.0005

GLU 177 ALA 178 -0.0002

ALA 178 MET 179 -0.0000

MET 179 LEU 180 0.0002

LEU 180 VAL 181 -0.0002

VAL 181 THR 182 0.0002

THR 182 LEU 183 -0.0063

LEU 183 VAL 184 -0.0002

VAL 184 ALA 185 -0.0002

ALA 185 ALA 186 -0.0002

ALA 186 ARG 187 0.0001

ARG 187 ASP 188 -0.0002

ASP 188 ALA 189 -0.0004

ALA 189 ALA 190 -0.0001

ALA 190 LEU 191 0.0002

LEU 191 ARG 192 0.0001

ARG 192 ARG 193 -0.0086

ARG 193 SER 194 -0.0001

SER 194 GLY 195 -0.0002

GLY 195 SER 196 0.0001

SER 196 ASP 197 -0.0002

ASP 197 GLY 198 -0.0003

GLY 198 VAL 199 -0.0003

VAL 199 ALA 200 0.0002

ALA 200 GLY 201 -0.0002

GLY 201 LEU 202 0.0001

LEU 202 HIS 203 -0.0168

HIS 203 ARG 204 -0.0000

ARG 204 LEU 205 -0.0003

LEU 205 ALA 206 -0.0002

ALA 206 VAL 207 -0.0000

VAL 207 TYR 208 0.0001

TYR 208 ALA 209 0.0003

ALA 209 ALA 210 0.0001

ALA 210 ASP 211 0.0002

ASP 211 GLN 212 0.0002

GLN 212 THR 213 -0.0026

THR 213 HIS 214 -0.0004

HIS 214 SER 215 0.0003

SER 215 THR 216 0.0000

THR 216 PHE 217 -0.0002

PHE 217 PHE 218 -0.0001

PHE 218 LYS 219 0.0003

LYS 219 ALA 220 0.0002

ALA 220 CYS 221 0.0002

CYS 221 ARG 222 -0.0002

ARG 222 LEU 223 -0.0104

LEU 223 ALA 224 0.0001

ALA 224 GLY 225 0.0000

GLY 225 PHE 226 0.0002

PHE 226 ASP 227 -0.0002

ASP 227 PRO 228 0.0004

PRO 228 ALA 229 -0.0002

ALA 229 ASN 230 0.0001

ASN 230 ILE 231 -0.0001

ILE 231 ARG 232 0.0005

ARG 232 SER 233 -0.0276

SER 233 ILE 234 -0.0001

ILE 234 PRO 235 -0.0003

PRO 235 THR 236 0.0003

THR 236 GLY 237 -0.0004

GLY 237 ALA 238 0.0001

ALA 238 GLU 239 0.0001

GLU 239 THR 240 0.0001

THR 240 ASP 241 0.0002

ASP 241 TYR 242 0.0001

TYR 242 GLY 243 0.0064

GLY 243 LEU 244 -0.0000

LEU 244 ASP 245 0.0003

ASP 245 PRO 246 -0.0000

PRO 246 ALA 247 0.0004

ALA 247 ARG 248 -0.0000

ARG 248 LEU 249 0.0002

LEU 249 LEU 250 -0.0001

LEU 250 GLU 251 -0.0001

GLU 251 ALA 252 0.0000

ALA 252 MET 253 -0.0035

MET 253 GLN 254 -0.0002

GLN 254 ALA 255 0.0002

ALA 255 ASP 256 -0.0002

ASP 256 ALA 257 0.0002

ALA 257 ASP 258 0.0001

ASP 258 ALA 259 -0.0003

ALA 259 GLY 260 -0.0001

GLY 260 LEU 261 0.0002

LEU 261 VAL 262 -0.0005

VAL 262 PRO 263 -0.0042

PRO 263 THR 264 -0.0005

THR 264 TYR 265 -0.0000

TYR 265 VAL 266 -0.0000

VAL 266 CYS 267 0.0000

CYS 267 ALA 268 0.0004

ALA 268 THR 269 -0.0002

THR 269 VAL 270 0.0000

VAL 270 GLY 271 0.0003

GLY 271 THR 272 -0.0002

THR 272 THR 273 0.0038

THR 273 SER 274 0.0000

SER 274 SER 275 0.0000

SER 275 ASN 276 0.0004

ASN 276 ALA 277 0.0000

ALA 277 VAL 278 -0.0001

VAL 278 ASP 279 0.0002

ASP 279 PRO 280 -0.0003

PRO 280 VAL 281 0.0002

VAL 281 GLY 282 0.0003

GLY 282 ALA 283 -0.0164

ALA 283 VAL 284 -0.0001

VAL 284 ALA 285 0.0003

ALA 285 ASP 286 0.0000

ASP 286 VAL 287 0.0000

VAL 287 ALA 288 0.0000

ALA 288 ALA 289 -0.0001

ALA 289 ARG 290 -0.0001

ARG 290 PHE 291 -0.0003

PHE 291 ALA 292 0.0000

ALA 292 ALA 293 0.0021

ALA 293 TRP 294 0.0004

TRP 294 VAL 295 -0.0000

VAL 295 HIS 296 -0.0002

HIS 296 VAL 297 -0.0002

VAL 297 ASP 298 0.0002

ASP 298 ALA 299 0.0001

ALA 299 ALA 300 -0.0002

ALA 300 TYR 301 0.0003

TYR 301 ALA 302 -0.0001

ALA 302 GLY 303 -0.0003

GLY 303 SER 304 -0.0000

SER 304 ALA 305 -0.0003

ALA 305 CYS 306 0.0003

CYS 306 ILE 307 0.0000

ILE 307 CYS 308 0.0001

CYS 308 PRO 309 -0.0000

PRO 309 GLU 310 0.0001

GLU 310 PHE 311 0.0001

PHE 311 ARG 312 -0.0001

ARG 312 HIS 313 -0.0120

HIS 313 HIS 314 0.0002

HIS 314 LEU 315 -0.0002

LEU 315 ASP 316 -0.0001

ASP 316 GLY 317 -0.0003

GLY 317 VAL 318 -0.0000

VAL 318 GLU 319 0.0002

GLU 319 ARG 320 -0.0003

ARG 320 VAL 321 -0.0003

VAL 321 ASP 322 0.0003

ASP 322 SER 323 -0.0075

SER 323 ILE 324 0.0002

ILE 324 SER 325 -0.0002

SER 325 MET 326 0.0002

MET 326 SER 327 0.0002

SER 327 PRO 328 -0.0001

PRO 328 HIS 329 -0.0003

HIS 329 LYS 330 0.0001

LYS 330 TRP 331 -0.0003

TRP 331 LEU 332 -0.0003

LEU 332 MET 333 -0.0150

MET 333 THR 334 -0.0000

THR 334 CYS 335 0.0001

CYS 335 LEU 336 0.0002

LEU 336 ASP 337 -0.0003

ASP 337 CYS 338 0.0003

CYS 338 THR 339 -0.0002

THR 339 CYS 340 0.0001

CYS 340 LEU 341 0.0001

LEU 341 TYR 342 -0.0003

TYR 342 VAL 343 -0.0169

VAL 343 ARG 344 0.0003

ARG 344 ASP 345 0.0001

ASP 345 THR 346 -0.0003

THR 346 HIS 347 -0.0001

HIS 347 ARG 348 0.0002

ARG 348 LEU 349 0.0003

LEU 349 THR 350 0.0003

THR 350 GLY 351 0.0000

GLY 351 SER 352 -0.0001

SER 352 LEU 353 -0.0026

LEU 353 GLU 354 0.0002

GLU 354 THR 355 -0.0002

THR 355 ASN 356 0.0001

ASN 356 PRO 357 -0.0000

PRO 357 GLU 358 0.0000

GLU 358 TYR 359 -0.0002

TYR 359 LEU 360 0.0003

LEU 360 LYS 361 -0.0002

LYS 361 ASN 362 -0.0003

ASN 362 HIS 363 -0.0114

HIS 363 ALA 364 -0.0001

ALA 364 SER 365 -0.0000

SER 365 ASP 366 -0.0000

ASP 366 SER 367 0.0002

SER 367 GLY 368 0.0004

GLY 368 GLU 369 -0.0002

GLU 369 VAL 370 0.0002

VAL 370 THR 371 0.0001

THR 371 ASP 372 0.0003

ASP 372 LEU 373 0.0095

LEU 373 LYS 374 0.0002

LYS 374 ASP 375 0.0004

ASP 375 MET 376 -0.0003

MET 376 GLN 377 0.0000

GLN 377 VAL 378 -0.0000

VAL 378 GLY 379 -0.0000

GLY 379 VAL 380 -0.0000

VAL 380 GLY 381 -0.0000

GLY 381 ARG 382 0.0003

ARG 382 ARG 383 0.0070

ARG 383 PHE 384 0.0003

PHE 384 ARG 385 -0.0001

ARG 385 GLY 386 0.0001

GLY 386 LEU 387 0.0001

LEU 387 LYS 388 0.0000

LYS 388 LEU 389 -0.0001

LEU 389 TRP 390 -0.0004

TRP 390 MET 391 0.0003

MET 391 VAL 392 -0.0000

VAL 392 MET 393 -0.0113

MET 393 ARG 394 0.0003

ARG 394 THR 395 -0.0001

THR 395 TYR 396 0.0004

TYR 396 GLY 397 -0.0001

GLY 397 VAL 398 0.0001

VAL 398 ALA 399 0.0002

ALA 399 LYS 400 -0.0002

LYS 400 LEU 401 0.0000

LEU 401 GLN 402 -0.0002

GLN 402 GLU 403 0.0255

GLU 403 HIS 404 0.0002

HIS 404 ILE 405 0.0002

ILE 405 ARG 406 0.0002

ARG 406 SER 407 0.0004

SER 407 ASP 408 0.0005

ASP 408 VAL 409 0.0000

VAL 409 ALA 410 -0.0004

ALA 410 MET 411 -0.0002

MET 411 ALA 412 -0.0002

ALA 412 LYS 413 -0.0067

LYS 413 VAL 414 -0.0002

VAL 414 PHE 415 0.0000

PHE 415 GLU 416 -0.0004

GLU 416 ASP 417 0.0000

ASP 417 LEU 418 -0.0001

LEU 418 VAL 419 0.0003

VAL 419 ARG 420 -0.0002

ARG 420 GLY 421 0.0002

GLY 421 ASP 422 0.0001

ASP 422 ASP 423 0.0065

ASP 423 ARG 424 -0.0002

ARG 424 PHE 425 -0.0002

PHE 425 GLU 426 0.0001

GLU 426 VAL 427 -0.0002

VAL 427 VAL 428 -0.0002

VAL 428 VAL 429 -0.0001

VAL 429 PRO 430 0.0002

PRO 430 ARG 431 -0.0001

ARG 431 ASN 432 0.0002

ASN 432 PHE 433 -0.0075

PHE 433 ALA 434 -0.0002

ALA 434 LEU 435 0.0001

LEU 435 VAL 436 0.0001

VAL 436 CYS 437 -0.0001

CYS 437 PHE 438 0.0002

PHE 438 ARG 439 -0.0001

ARG 439 ILE 440 -0.0000

ILE 440 ARG 441 -0.0001

ARG 441 ALA 442 -0.0001

ALA 442 GLY 443 -0.0075

GLY 443 ALA 444 -0.0000

ALA 444 GLY 445 -0.0001

GLY 445 ALA 446 -0.0001

ALA 446 ALA 447 -0.0000

ALA 447 ALA 448 -0.0002

ALA 448 ALA 449 0.0002

ALA 449 THR 450 -0.0002

THR 450 GLU 451 0.0000

GLU 451 GLU 452 0.0002

GLU 452 ASP 453 0.0060

ASP 453 ALA 454 -0.0000

ALA 454 ASP 455 0.0002

ASP 455 GLU 456 -0.0000

GLU 456 ALA 457 0.0001

ALA 457 ASN 458 0.0001

ASN 458 ARG 459 0.0001

ARG 459 GLU 460 -0.0004

GLU 460 LEU 461 -0.0002

LEU 461 MET 462 -0.0001

MET 462 GLU 463 0.0025

GLU 463 ARG 464 -0.0000

ARG 464 LEU 465 0.0002

LEU 465 ASN 466 -0.0004

ASN 466 LYS 467 0.0000

LYS 467 THR 468 -0.0002

THR 468 GLY 469 -0.0003

GLY 469 LYS 470 0.0000

LYS 470 ALA 471 -0.0000

ALA 471 TYR 472 -0.0001

TYR 472 VAL 473 0.0130

VAL 473 ALA 474 -0.0003

ALA 474 HIS 475 0.0002

HIS 475 THR 476 0.0003

THR 476 VAL 477 -0.0005

VAL 477 VAL 478 -0.0001

VAL 478 GLY 479 0.0002

GLY 479 GLY 480 0.0003

GLY 480 ARG 481 0.0002

ARG 481 PHE 482 -0.0003

PHE 482 VAL 483 0.0033

VAL 483 LEU 484 0.0001

LEU 484 ARG 485 0.0000

ARG 485 PHE 486 -0.0002

PHE 486 ALA 487 -0.0002

ALA 487 VAL 488 0.0003

VAL 488 GLY 489 0.0002

GLY 489 SER 490 -0.0003

SER 490 SER 491 0.0002

SER 491 LEU 492 -0.0002

LEU 492 GLN 493 0.0156

GLN 493 GLU 494 0.0001

GLU 494 GLU 495 -0.0001

GLU 495 HIS 496 0.0000

HIS 496 HIS 497 -0.0004

HIS 497 VAL 498 -0.0001

VAL 498 ARG 499 0.0001

ARG 499 SER 500 0.0001

SER 500 ALA 501 -0.0002

ALA 501 TRP 502 0.0001

TRP 502 GLU 503 0.0107

GLU 503 LEU 504 0.0000

LEU 504 ILE 505 -0.0001

ILE 505 LYS 506 -0.0001

LYS 506 LYS 507 0.0003

LYS 507 THR 508 0.0001

THR 508 THR 509 0.0000

THR 509 THR 510 -0.0001

THR 510 GLU 511 0.0006

GLU 511 MET 512 0.0001

MET 512 MET 513 -0.0034

MET 513 ASN 514 0.0001

ASN 514 THR 21 0.0132

THR 21 PHE 22 0.0000

PHE 22 GLN 23 0.0001

GLN 23 PRO 24 -0.0001

PRO 24 LEU 25 -0.0002

LEU 25 ASN 26 0.0004

ASN 26 ALA 27 -0.0000

ALA 27 ASP 28 0.0001

ASP 28 ASP 29 -0.0003

ASP 29 VAL 30 -0.0002

VAL 30 ARG 31 0.0200

ARG 31 SER 32 -0.0001

SER 32 TYR 33 0.0001

TYR 33 LEU 34 0.0002

LEU 34 HIS 35 0.0001

HIS 35 LYS 36 0.0003

LYS 36 ALA 37 -0.0003

ALA 37 VAL 38 -0.0001

VAL 38 ASP 39 -0.0003

ASP 39 PHE 40 0.0001

PHE 40 ILE 41 0.0027

ILE 41 SER 42 -0.0001

SER 42 ASP 43 0.0002

ASP 43 TYR 44 0.0002

TYR 44 TYR 45 0.0002

TYR 45 LYS 46 -0.0001

LYS 46 SER 47 0.0001

SER 47 VAL 48 -0.0001

VAL 48 GLU 49 0.0002

GLU 49 SER 50 0.0002

SER 50 MET 51 -0.0143

MET 51 PRO 52 0.0003

PRO 52 VAL 53 -0.0000

VAL 53 LEU 54 -0.0000

LEU 54 PRO 55 0.0004

PRO 55 ASN 56 -0.0003

ASN 56 VAL 57 0.0000

VAL 57 LYS 58 -0.0001

LYS 58 PRO 59 0.0003

PRO 59 GLY 60 -0.0005

GLY 60 TYR 61 -0.0217

TYR 61 LEU 62 -0.0003

LEU 62 GLN 63 0.0004

GLN 63 ASP 64 0.0002

ASP 64 GLU 65 0.0002

GLU 65 LEU 66 0.0003

LEU 66 ARG 67 0.0001

ARG 67 ALA 68 -0.0004

ALA 68 SER 69 0.0000

SER 69 PRO 70 -0.0002

PRO 70 PRO 71 -0.0054

PRO 71 THR 72 -0.0003

THR 72 TYR 73 0.0000

TYR 73 SER 74 -0.0003

SER 74 ALA 75 -0.0001

ALA 75 PRO 76 -0.0002

PRO 76 PHE 77 0.0000

PHE 77 ASP 78 0.0000

ASP 78 VAL 79 -0.0002

VAL 79 THR 80 0.0002

THR 80 MET 81 0.0108

MET 81 LYS 82 -0.0003

LYS 82 GLU 83 -0.0001

GLU 83 LEU 84 0.0001

LEU 84 ARG 85 -0.0004

ARG 85 SER 86 -0.0002

SER 86 SER 87 0.0002

SER 87 VAL 88 -0.0001

VAL 88 VAL 89 0.0001

VAL 89 PRO 90 -0.0003

PRO 90 GLY 91 0.0020

GLY 91 MET 92 0.0003

MET 92 THR 93 -0.0001

THR 93 HIS 94 0.0002

HIS 94 TRP 95 -0.0000

TRP 95 ALA 96 -0.0003

ALA 96 SER 97 0.0003

SER 97 PRO 98 -0.0004

PRO 98 ASN 99 -0.0003

ASN 99 PHE 100 0.0000

PHE 100 PHE 101 0.0384

PHE 101 ALA 102 0.0000

ALA 102 PHE 103 0.0001

PHE 103 PHE 104 -0.0000

PHE 104 PRO 105 0.0000

PRO 105 SER 106 0.0000

SER 106 THR 107 0.0002

THR 107 ASN 108 0.0003

ASN 108 SER 109 0.0000

SER 109 ALA 110 0.0001

ALA 110 ALA 111 -0.0372

ALA 111 ALA 112 -0.0004

ALA 112 ILE 113 0.0001

ILE 113 ALA 114 0.0001

ALA 114 GLY 115 -0.0002

GLY 115 ASP 116 0.0006

ASP 116 LEU 117 -0.0002

LEU 117 ILE 118 0.0002

ILE 118 ALA 119 0.0001

ALA 119 SER 120 -0.0001

SER 120 ALA 121 0.0063

ALA 121 MET 122 0.0002

MET 122 ASN 123 0.0003

ASN 123 THR 124 -0.0002

THR 124 VAL 125 0.0000

VAL 125 GLY 126 -0.0000

GLY 126 PHE 127 -0.0000

PHE 127 THR 128 0.0000

THR 128 TRP 129 -0.0003

TRP 129 GLN 130 0.0002

GLN 130 ALA 131 -0.0048

ALA 131 SER 132 -0.0001

SER 132 PRO 133 -0.0001

PRO 133 ALA 134 0.0000

ALA 134 ALA 135 -0.0004

ALA 135 THR 136 0.0001

THR 136 GLU 137 -0.0001

GLU 137 MET 138 0.0002

MET 138 GLU 139 0.0002

GLU 139 VAL 140 -0.0000

VAL 140 LEU 141 0.0073

LEU 141 ALA 142 -0.0000

ALA 142 LEU 143 0.0004

LEU 143 ASP 144 0.0002

ASP 144 TRP 145 -0.0003

TRP 145 LEU 146 -0.0004

LEU 146 ALA 147 -0.0001

ALA 147 GLN 148 0.0003

GLN 148 MET 149 -0.0001

MET 149 LEU 150 -0.0001

LEU 150 ASN 151 -0.0175

ASN 151 LEU 152 0.0000

LEU 152 PRO 153 -0.0002

PRO 153 THR 154 0.0001

THR 154 SER 155 0.0001

SER 155 PHE 156 -0.0002

PHE 156 MET 157 -0.0003

MET 157 ASN 158 0.0001

ASN 158 ARG 159 -0.0003

ARG 159 THR 160 0.0002

THR 160 GLY 161 -0.0085

GLY 161 GLU 162 -0.0001

GLU 162 GLY 163 0.0005

GLY 163 ARG 164 -0.0001

ARG 164 GLY 165 -0.0001

GLY 165 THR 166 0.0001

THR 166 GLY 167 0.0002

GLY 167 GLY 168 -0.0002

GLY 168 GLY 169 0.0004

GLY 169 VAL 170 -0.0002

VAL 170 ILE 171 0.0018

ILE 171 LEU 172 0.0000

LEU 172 GLY 173 -0.0002

GLY 173 THR 174 -0.0002

THR 174 THR 175 0.0003

THR 175 SER 176 -0.0001

SER 176 GLU 177 0.0004

GLU 177 ALA 178 0.0001

ALA 178 MET 179 0.0001

MET 179 LEU 180 0.0001

LEU 180 VAL 181 -0.0003

VAL 181 THR 182 -0.0001

THR 182 LEU 183 0.0004

LEU 183 VAL 184 0.0003

VAL 184 ALA 185 -0.0002

ALA 185 ALA 186 -0.0002

ALA 186 ARG 187 -0.0003

ARG 187 ASP 188 -0.0003

ASP 188 ALA 189 0.0002

ALA 189 ALA 190 0.0003

ALA 190 LEU 191 0.0121

LEU 191 ARG 192 -0.0002

ARG 192 ARG 193 -0.0003

ARG 193 SER 194 0.0000

SER 194 GLY 195 0.0003

GLY 195 SER 196 -0.0004

SER 196 ASP 197 -0.0002

ASP 197 GLY 198 -0.0003

GLY 198 VAL 199 0.0001

VAL 199 ALA 200 0.0000

ALA 200 GLY 201 -0.0201

GLY 201 LEU 202 -0.0001

LEU 202 HIS 203 -0.0003

HIS 203 ARG 204 -0.0001

ARG 204 LEU 205 -0.0001

LEU 205 ALA 206 -0.0003

ALA 206 VAL 207 0.0004

VAL 207 TYR 208 -0.0003

TYR 208 ALA 209 0.0002

ALA 209 ALA 210 -0.0002

ALA 210 ASP 211 0.0123

ASP 211 GLN 212 0.0004

GLN 212 THR 213 0.0001

THR 213 HIS 214 0.0001

HIS 214 SER 215 0.0001

SER 215 THR 216 0.0000

THR 216 PHE 217 0.0001

PHE 217 PHE 218 -0.0003

PHE 218 LYS 219 -0.0000

LYS 219 ALA 220 0.0002

ALA 220 CYS 221 0.0012

CYS 221 ARG 222 0.0003

ARG 222 LEU 223 -0.0001

LEU 223 ALA 224 -0.0002

ALA 224 GLY 225 -0.0001

GLY 225 PHE 226 0.0001

PHE 226 ASP 227 0.0001

ASP 227 PRO 228 -0.0001

PRO 228 ALA 229 0.0000

ALA 229 ASN 230 -0.0005

ASN 230 ILE 231 -0.0073

ILE 231 ARG 232 0.0001

ARG 232 SER 233 -0.0000

SER 233 ILE 234 -0.0002

ILE 234 PRO 235 0.0001

PRO 235 THR 236 0.0002

THR 236 GLY 237 0.0002

GLY 237 ALA 238 0.0002

ALA 238 GLU 239 -0.0004

GLU 239 THR 240 0.0003

THR 240 ASP 241 0.0023

ASP 241 TYR 242 -0.0002

TYR 242 GLY 243 0.0000

GLY 243 LEU 244 -0.0001

LEU 244 ASP 245 0.0003

ASP 245 PRO 246 -0.0003

PRO 246 ALA 247 -0.0001

ALA 247 ARG 248 0.0002

ARG 248 LEU 249 -0.0004

LEU 249 LEU 250 0.0004

LEU 250 GLU 251 -0.0039

GLU 251 ALA 252 0.0002

ALA 252 MET 253 -0.0001

MET 253 GLN 254 -0.0002

GLN 254 ALA 255 -0.0003

ALA 255 ASP 256 -0.0003

ASP 256 ALA 257 -0.0001

ALA 257 ASP 258 0.0001

ASP 258 ALA 259 0.0001

ALA 259 GLY 260 -0.0001

GLY 260 LEU 261 -0.0000

LEU 261 VAL 262 -0.0001

VAL 262 PRO 263 -0.0003

PRO 263 THR 264 0.0002

THR 264 TYR 265 -0.0003

TYR 265 VAL 266 0.0003

VAL 266 CYS 267 -0.0001

CYS 267 ALA 268 -0.0001

ALA 268 THR 269 0.0002

THR 269 VAL 270 -0.0002

VAL 270 GLY 271 0.0068

GLY 271 THR 272 -0.0002

THR 272 THR 273 -0.0001

THR 273 SER 274 0.0001

SER 274 SER 275 -0.0000

SER 275 ASN 276 0.0000

ASN 276 ALA 277 0.0001

ALA 277 VAL 278 0.0001

VAL 278 ASP 279 -0.0003

ASP 279 PRO 280 0.0003

PRO 280 VAL 281 -0.0155

VAL 281 GLY 282 -0.0000

GLY 282 ALA 283 0.0000

ALA 283 VAL 284 -0.0002

VAL 284 ALA 285 -0.0004

ALA 285 ASP 286 -0.0004

ASP 286 VAL 287 -0.0002

VAL 287 ALA 288 0.0002

ALA 288 ALA 289 0.0001

ALA 289 ARG 290 0.0000

ARG 290 PHE 291 -0.0021

PHE 291 ALA 292 -0.0002

ALA 292 ALA 293 0.0001

ALA 293 TRP 294 -0.0003

TRP 294 VAL 295 0.0002

VAL 295 HIS 296 0.0001

HIS 296 VAL 297 -0.0001

VAL 297 ASP 298 0.0002

ASP 298 ALA 299 0.0002

ALA 299 ALA 300 -0.0002

ALA 300 TYR 301 0.0028

TYR 301 ALA 302 -0.0001

ALA 302 GLY 303 -0.0000

GLY 303 SER 304 0.0003

SER 304 ALA 305 0.0002

ALA 305 CYS 306 0.0002

CYS 306 ILE 307 -0.0001

ILE 307 CYS 308 0.0004

CYS 308 PRO 309 0.0001

PRO 309 GLU 310 0.0005

GLU 310 PHE 311 -0.0070

PHE 311 ARG 312 -0.0002

ARG 312 HIS 313 -0.0004

HIS 313 HIS 314 -0.0003

HIS 314 LEU 315 0.0005

LEU 315 ASP 316 -0.0005

ASP 316 GLY 317 -0.0000

GLY 317 VAL 318 0.0000

VAL 318 GLU 319 -0.0000

GLU 319 ARG 320 -0.0004

ARG 320 VAL 321 0.0109

VAL 321 ASP 322 -0.0001

ASP 322 SER 323 -0.0001

SER 323 ILE 324 0.0002

ILE 324 SER 325 -0.0003

SER 325 MET 326 -0.0003

MET 326 SER 327 0.0006

SER 327 PRO 328 -0.0001

PRO 328 HIS 329 0.0000

HIS 329 LYS 330 -0.0002

LYS 330 TRP 331 -0.0085

TRP 331 LEU 332 0.0002

LEU 332 MET 333 -0.0003

MET 333 THR 334 -0.0004

THR 334 CYS 335 0.0002

CYS 335 LEU 336 0.0002

LEU 336 ASP 337 -0.0004

ASP 337 CYS 338 0.0001

CYS 338 THR 339 0.0000

THR 339 CYS 340 0.0001

CYS 340 LEU 341 0.0156

LEU 341 TYR 342 -0.0003

TYR 342 VAL 343 0.0002

VAL 343 ARG 344 -0.0000

ARG 344 ASP 345 -0.0000

ASP 345 THR 346 -0.0001

THR 346 HIS 347 0.0001

HIS 347 ARG 348 0.0002

ARG 348 LEU 349 0.0002

LEU 349 GLY 368 -0.0126

GLY 368 GLU 369 0.0004

GLU 369 VAL 370 0.0000

VAL 370 THR 371 -0.0000

THR 371 ASP 372 -0.0001

ASP 372 LEU 373 -0.0000

LEU 373 LYS 374 -0.0001

LYS 374 ASP 375 -0.0000

ASP 375 MET 376 0.0002

MET 376 GLN 377 0.0001

GLN 377 VAL 378 -0.0025

VAL 378 GLY 379 -0.0001

GLY 379 VAL 380 0.0000

VAL 380 GLY 381 0.0002

GLY 381 ARG 382 0.0002

ARG 382 ARG 383 -0.0003

ARG 383 PHE 384 -0.0000

PHE 384 ARG 385 0.0002

ARG 385 GLY 386 0.0001

GLY 386 LEU 387 -0.0000

LEU 387 LYS 388 0.0192

LYS 388 LEU 389 0.0003

LEU 389 TRP 390 0.0001

TRP 390 MET 391 -0.0003

MET 391 VAL 392 0.0001

VAL 392 MET 393 0.0003

MET 393 ARG 394 0.0002

ARG 394 THR 395 0.0002

THR 395 TYR 396 0.0001

TYR 396 GLY 397 0.0005

GLY 397 VAL 398 -0.0052

VAL 398 ALA 399 -0.0001

ALA 399 LYS 400 -0.0002

LYS 400 LEU 401 0.0002

LEU 401 GLN 402 0.0003

GLN 402 GLU 403 -0.0000

GLU 403 HIS 404 0.0002

HIS 404 ILE 405 0.0004

ILE 405 ARG 406 -0.0001

ARG 406 SER 407 0.0004

SER 407 ASP 408 -0.0801

ASP 408 VAL 409 -0.0004

VAL 409 ALA 410 0.0003

ALA 410 MET 411 0.0001

MET 411 ALA 412 -0.0002

ALA 412 LYS 413 -0.0004

LYS 413 VAL 414 0.0000

VAL 414 PHE 415 0.0001

PHE 415 GLU 416 -0.0001

GLU 416 ASP 417 -0.0000

ASP 417 LEU 418 -0.0232

LEU 418 VAL 419 -0.0001

VAL 419 ARG 420 -0.0000

ARG 420 GLY 421 0.0001

GLY 421 ASP 422 0.0002

ASP 422 ASP 423 0.0001

ASP 423 ARG 424 -0.0003

ARG 424 PHE 425 0.0000

PHE 425 GLU 426 -0.0000

GLU 426 VAL 427 0.0004

VAL 427 VAL 428 0.0218

VAL 428 VAL 429 0.0001

VAL 429 PRO 430 -0.0001

PRO 430 ARG 431 -0.0000

ARG 431 ASN 432 0.0000

ASN 432 PHE 433 0.0003

PHE 433 ALA 434 -0.0004

ALA 434 LEU 435 -0.0003

LEU 435 VAL 436 0.0001

VAL 436 CYS 437 -0.0002

CYS 437 PHE 438 -0.0310

PHE 438 ARG 439 0.0004

ARG 439 ILE 440 -0.0004

ILE 440 ARG 441 -0.0001

ARG 441 ALA 442 -0.0002

ALA 442 GLY 443 0.0002

GLY 443 ALA 444 0.0004

ALA 444 GLY 445 0.0002

GLY 445 ALA 446 -0.0000

ALA 446 ALA 447 0.0002

ALA 447 ALA 448 0.0067

ALA 448 ALA 449 0.0001

ALA 449 THR 450 0.0001

THR 450 GLU 451 -0.0000

GLU 451 GLU 452 -0.0001

GLU 452 ASP 453 0.0000

ASP 453 ALA 454 -0.0000

ALA 454 ASP 455 -0.0003

ASP 455 GLU 456 0.0000

GLU 456 ALA 457 0.0002

ALA 457 ASN 458 0.0052

ASN 458 ARG 459 -0.0001

ARG 459 GLU 460 0.0001

GLU 460 LEU 461 -0.0005

LEU 461 MET 462 -0.0001

MET 462 GLU 463 0.0003

GLU 463 ARG 464 -0.0004

ARG 464 LEU 465 -0.0002

LEU 465 ASN 466 0.0003

ASN 466 LYS 467 0.0000

LYS 467 THR 468 -0.0186

THR 468 GLY 469 0.0001

GLY 469 LYS 470 0.0003

LYS 470 ALA 471 -0.0001

ALA 471 TYR 472 -0.0001

TYR 472 VAL 473 0.0001

VAL 473 ALA 474 -0.0002

ALA 474 HIS 475 -0.0003

HIS 475 THR 476 0.0001

THR 476 VAL 477 0.0004

VAL 477 VAL 478 0.0139

VAL 478 GLY 479 0.0000

GLY 479 GLY 480 0.0001

GLY 480 ARG 481 -0.0002

ARG 481 PHE 482 0.0001

PHE 482 VAL 483 -0.0001

VAL 483 LEU 484 0.0002

LEU 484 ARG 485 0.0001

ARG 485 PHE 486 0.0003

PHE 486 ALA 487 0.0001

ALA 487 VAL 488 -0.0209

VAL 488 GLY 489 0.0001

GLY 489 SER 490 0.0001

SER 490 SER 491 -0.0001

SER 491 LEU 492 0.0002

LEU 492 GLN 493 -0.0001

GLN 493 GLU 494 -0.0001

GLU 494 GLU 495 0.0000

GLU 495 HIS 496 0.0003

HIS 496 HIS 497 -0.0002

HIS 497 VAL 498 0.0166

VAL 498 ARG 499 -0.0003

ARG 499 SER 500 -0.0003

SER 500 ALA 501 0.0004

ALA 501 TRP 502 0.0005

TRP 502 GLU 503 -0.0003

GLU 503 LEU 504 -0.0000

LEU 504 ILE 505 0.0002

ILE 505 LYS 506 -0.0003

LYS 506 LYS 507 -0.0001

LYS 507 THR 508 -0.0004

THR 508 THR 509 0.0001

THR 509 THR 510 0.0003

THR 510 GLU 511 0.0003

GLU 511 MET 512 0.0002

MET 512 MET 513 0.0006

MET 513 ASN 514 0.0002

ASN 514 THR 21 -0.0536

THR 21 PHE 22 0.0002

PHE 22 GLN 23 -0.0001

GLN 23 PRO 24 -0.0001

PRO 24 LEU 25 0.0001

LEU 25 ASN 26 -0.0002

ASN 26 ALA 27 0.0002

ALA 27 ASP 28 0.0001

ASP 28 ASP 29 0.0001

ASP 29 VAL 30 0.0002

VAL 30 ARG 31 0.0484

ARG 31 SER 32 -0.0001

SER 32 TYR 33 0.0001

TYR 33 LEU 34 0.0003

LEU 34 HIS 35 0.0003

HIS 35 LYS 36 -0.0001

LYS 36 ALA 37 0.0004

ALA 37 VAL 38 -0.0002

VAL 38 ASP 39 -0.0000

ASP 39 PHE 40 -0.0002

PHE 40 ILE 41 -0.0328

ILE 41 SER 42 -0.0002

SER 42 ASP 43 0.0000

ASP 43 TYR 44 -0.0001

TYR 44 TYR 45 -0.0002

TYR 45 LYS 46 0.0005

LYS 46 SER 47 -0.0002

SER 47 VAL 48 0.0004

VAL 48 GLU 49 0.0005

GLU 49 SER 50 0.0003

SER 50 MET 51 -0.0365

MET 51 PRO 52 -0.0001

PRO 52 VAL 53 -0.0001

VAL 53 LEU 54 -0.0002

LEU 54 PRO 55 0.0000

PRO 55 ASN 56 0.0003

ASN 56 VAL 57 0.0000

VAL 57 LYS 58 -0.0002

LYS 58 PRO 59 0.0001

PRO 59 GLY 60 0.0000

GLY 60 TYR 61 0.0382

TYR 61 LEU 62 0.0003

LEU 62 GLN 63 -0.0003

GLN 63 ASP 64 0.0001

ASP 64 GLU 65 0.0001

GLU 65 LEU 66 0.0002

LEU 66 ARG 67 -0.0001

ARG 67 ALA 68 -0.0002

ALA 68 SER 69 -0.0001

SER 69 PRO 70 -0.0002

PRO 70 PRO 71 0.1351

PRO 71 THR 72 -0.0001

THR 72 TYR 73 -0.0000

TYR 73 SER 74 -0.0001

SER 74 ALA 75 0.0002

ALA 75 PRO 76 0.0004

PRO 76 PHE 77 0.0003

PHE 77 ASP 78 0.0001

ASP 78 VAL 79 0.0002

VAL 79 THR 80 0.0001

THR 80 MET 81 0.0289

MET 81 LYS 82 0.0000

LYS 82 GLU 83 -0.0000

GLU 83 LEU 84 -0.0002

LEU 84 ARG 85 -0.0002

ARG 85 SER 86 0.0000

SER 86 SER 87 0.0004

SER 87 VAL 88 -0.0001

VAL 88 VAL 89 0.0001

VAL 89 PRO 90 -0.0003

PRO 90 GLY 91 0.0611

GLY 91 MET 92 -0.0004

MET 92 THR 93 0.0004

THR 93 HIS 94 0.0001

HIS 94 TRP 95 -0.0003

TRP 95 ALA 96 -0.0000

ALA 96 SER 97 -0.0004

SER 97 PRO 98 0.0000

PRO 98 ASN 99 0.0002

ASN 99 PHE 100 -0.0004

PHE 100 PHE 101 -0.0045

PHE 101 ALA 102 0.0002

ALA 102 PHE 103 -0.0003

PHE 103 PHE 104 0.0003

PHE 104 PRO 105 0.0000

PRO 105 SER 106 -0.0006

SER 106 THR 107 0.0001

THR 107 ASN 108 -0.0000

ASN 108 SER 109 -0.0001

SER 109 ALA 110 0.0004

ALA 110 ALA 111 0.0356

ALA 111 ALA 112 0.0001

ALA 112 ILE 113 0.0001

ILE 113 ALA 114 -0.0000

ALA 114 GLY 115 -0.0000

GLY 115 ASP 116 -0.0001

ASP 116 LEU 117 0.0002

LEU 117 ILE 118 0.0002

ILE 118 ALA 119 0.0001

ALA 119 SER 120 0.0002

SER 120 ALA 121 0.0032

ALA 121 MET 122 0.0004

MET 122 ASN 123 -0.0003

ASN 123 THR 124 -0.0000

THR 124 VAL 125 0.0004

VAL 125 GLY 126 -0.0001

GLY 126 PHE 127 0.0002

PHE 127 THR 128 0.0003

THR 128 TRP 129 -0.0002

TRP 129 GLN 130 -0.0001

GLN 130 ALA 131 -0.0012

ALA 131 SER 132 0.0006

SER 132 PRO 133 -0.0003

PRO 133 ALA 134 -0.0001

ALA 134 ALA 135 -0.0000

ALA 135 THR 136 0.0003

THR 136 GLU 137 0.0002

GLU 137 MET 138 -0.0000

MET 138 GLU 139 -0.0002

GLU 139 VAL 140 -0.0001

VAL 140 LEU 141 0.0145

LEU 141 ALA 142 -0.0003

ALA 142 LEU 143 -0.0001

LEU 143 ASP 144 0.0002

ASP 144 TRP 145 0.0000

TRP 145 LEU 146 -0.0000

LEU 146 ALA 147 -0.0001

ALA 147 GLN 148 -0.0002

GLN 148 MET 149 -0.0001

MET 149 LEU 150 0.0002

LEU 150 ASN 151 0.0022

ASN 151 LEU 152 0.0002

LEU 152 PRO 153 0.0003

PRO 153 THR 154 -0.0002

THR 154 SER 155 0.0002

SER 155 PHE 156 -0.0004

PHE 156 MET 157 0.0000

MET 157 ASN 158 0.0000

ASN 158 GLY 163 0.0011

GLY 163 ARG 164 0.0001

ARG 164 GLY 165 -0.0003

GLY 165 THR 166 -0.0001

THR 166 GLY 167 0.0002

GLY 167 GLY 168 0.0005

GLY 168 GLY 169 -0.0003

GLY 169 VAL 170 0.0002

VAL 170 ILE 171 0.0003

ILE 171 LEU 172 -0.0001

LEU 172 GLY 173 0.0096

GLY 173 THR 174 0.0001

THR 174 THR 175 0.0003

THR 175 SER 176 0.0002

SER 176 GLU 177 -0.0003

GLU 177 ALA 178 -0.0001

ALA 178 MET 179 0.0003

MET 179 LEU 180 -0.0001

LEU 180 VAL 181 0.0002

VAL 181 THR 182 0.0003

THR 182 LEU 183 -0.0066

LEU 183 VAL 184 -0.0001

VAL 184 ALA 185 0.0002

ALA 185 ALA 186 -0.0001

ALA 186 ARG 187 -0.0003

ARG 187 ASP 188 -0.0003

ASP 188 ALA 189 0.0000

ALA 189 ALA 190 0.0003

ALA 190 LEU 191 -0.0003

LEU 191 ARG 192 0.0002

ARG 192 ARG 193 -0.0086

ARG 193 SER 194 0.0003

SER 194 GLY 195 -0.0004

GLY 195 SER 196 0.0000

SER 196 ASP 197 0.0001

ASP 197 GLY 198 -0.0002

GLY 198 VAL 199 -0.0003

VAL 199 ALA 200 0.0004

ALA 200 GLY 201 -0.0005

GLY 201 LEU 202 -0.0000

LEU 202 HIS 203 -0.0168

HIS 203 ARG 204 0.0002

ARG 204 LEU 205 0.0002

LEU 205 ALA 206 0.0001

ALA 206 VAL 207 0.0002

VAL 207 TYR 208 0.0002

TYR 208 ALA 209 -0.0002

ALA 209 ALA 210 0.0001

ALA 210 ASP 211 -0.0001

ASP 211 GLN 212 0.0000

GLN 212 THR 213 -0.0026

THR 213 HIS 214 0.0001

HIS 214 SER 215 0.0000

SER 215 THR 216 -0.0001

THR 216 PHE 217 0.0001

PHE 217 PHE 218 -0.0001

PHE 218 LYS 219 0.0001

LYS 219 ALA 220 0.0000

ALA 220 CYS 221 0.0003

CYS 221 ARG 222 0.0001

ARG 222 LEU 223 -0.0104

LEU 223 ALA 224 0.0000

ALA 224 GLY 225 -0.0003

GLY 225 PHE 226 0.0001

PHE 226 ASP 227 -0.0003

ASP 227 PRO 228 -0.0000

PRO 228 ALA 229 0.0003

ALA 229 ASN 230 0.0003

ASN 230 ILE 231 -0.0001

ILE 231 ARG 232 0.0004

ARG 232 SER 233 -0.0273

SER 233 ILE 234 0.0000

ILE 234 PRO 235 -0.0001

PRO 235 THR 236 -0.0002

THR 236 GLY 237 0.0003

GLY 237 ALA 238 -0.0001

ALA 238 GLU 239 0.0001

GLU 239 THR 240 0.0001

THR 240 ASP 241 0.0002

ASP 241 TYR 242 -0.0001

TYR 242 GLY 243 0.0067

GLY 243 LEU 244 0.0001

LEU 244 ASP 245 0.0002

ASP 245 PRO 246 -0.0002

PRO 246 ALA 247 0.0005

ALA 247 ARG 248 0.0000

ARG 248 LEU 249 -0.0001

LEU 249 LEU 250 0.0002

LEU 250 GLU 251 -0.0002

GLU 251 ALA 252 -0.0002

ALA 252 MET 253 -0.0030

MET 253 GLN 254 0.0002

GLN 254 ALA 255 -0.0002

ALA 255 ASP 256 -0.0005

ASP 256 ALA 257 -0.0001

ALA 257 ASP 258 -0.0001

ASP 258 ALA 259 0.0002

ALA 259 GLY 260 0.0002

GLY 260 LEU 261 -0.0001

LEU 261 VAL 262 -0.0001

VAL 262 PRO 263 -0.0045

PRO 263 THR 264 -0.0003

THR 264 TYR 265 0.0003

TYR 265 VAL 266 0.0002

VAL 266 CYS 267 -0.0000

CYS 267 ALA 268 -0.0002

ALA 268 THR 269 0.0005

THR 269 VAL 270 -0.0004

VAL 270 GLY 271 0.0003

GLY 271 THR 272 -0.0003

THR 272 THR 273 0.0038

THR 273 SER 274 -0.0003

SER 274 SER 275 0.0002

SER 275 ASN 276 -0.0001

ASN 276 ALA 277 0.0001

ALA 277 VAL 278 0.0003

VAL 278 ASP 279 0.0004

ASP 279 PRO 280 -0.0002

PRO 280 VAL 281 -0.0004

VAL 281 GLY 282 0.0004

GLY 282 ALA 283 -0.0163

ALA 283 VAL 284 -0.0000

VAL 284 ALA 285 -0.0004

ALA 285 ASP 286 0.0001

ASP 286 VAL 287 -0.0001

VAL 287 ALA 288 0.0001

ALA 288 ALA 289 -0.0001

ALA 289 ARG 290 0.0002

ARG 290 PHE 291 -0.0000

PHE 291 ALA 292 -0.0001

ALA 292 ALA 293 0.0019

ALA 293 TRP 294 -0.0001

TRP 294 VAL 295 0.0005

VAL 295 HIS 296 -0.0002

HIS 296 VAL 297 0.0001

VAL 297 ASP 298 0.0003

ASP 298 ALA 299 -0.0002

ALA 299 ALA 300 -0.0002

ALA 300 TYR 301 0.0002

TYR 301 ALA 302 -0.0004

ALA 302 GLY 303 -0.0005

GLY 303 SER 304 -0.0000

SER 304 ALA 305 -0.0005

ALA 305 CYS 306 0.0002

CYS 306 ILE 307 -0.0003

ILE 307 CYS 308 0.0002

CYS 308 PRO 309 -0.0002

PRO 309 GLU 310 -0.0004

GLU 310 PHE 311 0.0001

PHE 311 ARG 312 0.0001

ARG 312 HIS 313 -0.0125

HIS 313 HIS 314 -0.0002

HIS 314 LEU 315 0.0000

LEU 315 ASP 316 -0.0003

ASP 316 GLY 317 0.0001

GLY 317 VAL 318 0.0001

VAL 318 GLU 319 -0.0002

GLU 319 ARG 320 -0.0003

ARG 320 VAL 321 -0.0001

VAL 321 ASP 322 0.0001

ASP 322 SER 323 -0.0071

SER 323 ILE 324 0.0004

ILE 324 SER 325 -0.0002

SER 325 MET 326 -0.0002

MET 326 SER 327 0.0000

SER 327 PRO 328 -0.0000

PRO 328 HIS 329 0.0001

HIS 329 LYS 330 -0.0000

LYS 330 TRP 331 -0.0001

TRP 331 LEU 332 0.0001

LEU 332 MET 333 -0.0149

MET 333 THR 334 -0.0004

THR 334 CYS 335 0.0001

CYS 335 LEU 336 0.0000

LEU 336 ASP 337 0.0001

ASP 337 CYS 338 -0.0001

CYS 338 THR 339 0.0003

THR 339 CYS 340 -0.0003

CYS 340 LEU 341 0.0001

LEU 341 TYR 342 0.0002

TYR 342 VAL 343 -0.0170

VAL 343 ARG 344 -0.0001

ARG 344 ASP 345 -0.0001

ASP 345 THR 346 -0.0001

THR 346 HIS 347 -0.0005

HIS 347 ARG 348 0.0002

ARG 348 LEU 349 -0.0004

LEU 349 THR 350 -0.0002

THR 350 GLY 351 0.0003

GLY 351 SER 352 -0.0001

SER 352 LEU 353 -0.0031

LEU 353 GLU 354 0.0002

GLU 354 THR 355 0.0000

THR 355 ASN 356 -0.0000

ASN 356 PRO 357 0.0002

PRO 357 GLU 358 0.0002

GLU 358 TYR 359 -0.0001

TYR 359 LEU 360 -0.0001

LEU 360 LYS 361 0.0004

LYS 361 ASN 362 -0.0003

ASN 362 HIS 363 -0.0113

HIS 363 ALA 364 -0.0001

ALA 364 SER 365 -0.0000

SER 365 ASP 366 -0.0003

ASP 366 SER 367 -0.0002

SER 367 GLY 368 -0.0001

GLY 368 GLU 369 0.0001

GLU 369 VAL 370 0.0001

VAL 370 THR 371 0.0002

THR 371 ASP 372 -0.0002

ASP 372 LEU 373 0.0097

LEU 373 LYS 374 0.0005

LYS 374 ASP 375 0.0002

ASP 375 MET 376 -0.0005

MET 376 GLN 377 -0.0001

GLN 377 VAL 378 0.0000

VAL 378 GLY 379 -0.0000

GLY 379 VAL 380 -0.0001

VAL 380 GLY 381 -0.0001

GLY 381 ARG 382 0.0001

ARG 382 ARG 383 0.0071

ARG 383 PHE 384 0.0002

PHE 384 ARG 385 -0.0002

ARG 385 GLY 386 -0.0001

GLY 386 LEU 387 0.0001

LEU 387 LYS 388 0.0002

LYS 388 LEU 389 -0.0003

LEU 389 TRP 390 0.0000

TRP 390 MET 391 -0.0001

MET 391 VAL 392 0.0002

VAL 392 MET 393 -0.0110

MET 393 ARG 394 -0.0000

ARG 394 THR 395 0.0001

THR 395 TYR 396 -0.0002

TYR 396 GLY 397 0.0001

GLY 397 VAL 398 0.0000

VAL 398 ALA 399 0.0001

ALA 399 LYS 400 0.0001

LYS 400 LEU 401 -0.0003

LEU 401 GLN 402 0.0002

GLN 402 GLU 403 0.0257

GLU 403 HIS 404 -0.0001

HIS 404 ILE 405 -0.0002

ILE 405 ARG 406 0.0002

ARG 406 SER 407 -0.0001

SER 407 ASP 408 0.0002

ASP 408 VAL 409 0.0004

VAL 409 ALA 410 0.0005

ALA 410 MET 411 0.0000

MET 411 ALA 412 0.0000

ALA 412 LYS 413 -0.0069

LYS 413 VAL 414 -0.0000

VAL 414 PHE 415 0.0000

PHE 415 GLU 416 0.0002

GLU 416 ASP 417 -0.0001

ASP 417 LEU 418 -0.0001

LEU 418 VAL 419 -0.0003

VAL 419 ARG 420 -0.0003

ARG 420 GLY 421 -0.0000

GLY 421 ASP 422 0.0003

ASP 422 ASP 423 0.0060

ASP 423 ARG 424 0.0000

ARG 424 PHE 425 -0.0002

PHE 425 GLU 426 0.0002

GLU 426 VAL 427 0.0001

VAL 427 VAL 428 0.0001

VAL 428 VAL 429 -0.0002

VAL 429 PRO 430 0.0003

PRO 430 ARG 431 -0.0002

ARG 431 ASN 432 0.0004

ASN 432 PHE 433 -0.0075

PHE 433 ALA 434 -0.0002

ALA 434 LEU 435 0.0002

LEU 435 VAL 436 0.0000

VAL 436 CYS 437 0.0000

CYS 437 PHE 438 0.0001

PHE 438 ARG 439 0.0004

ARG 439 ILE 440 -0.0003

ILE 440 ARG 441 -0.0003

ARG 441 ALA 442 -0.0002

ALA 442 GLY 443 -0.0076

GLY 443 ALA 444 -0.0000

ALA 444 GLY 445 -0.0004

GLY 445 ALA 446 0.0003

ALA 446 ALA 447 0.0000

ALA 447 ALA 448 -0.0003

ALA 448 ALA 449 0.0002

ALA 449 THR 450 -0.0002

THR 450 GLU 451 0.0005

GLU 451 GLU 452 0.0001

GLU 452 ASP 453 0.0059

ASP 453 ALA 454 -0.0003

ALA 454 ASP 455 -0.0001

ASP 455 GLU 456 0.0002

GLU 456 ALA 457 0.0004

ALA 457 ASN 458 -0.0001

ASN 458 ARG 459 -0.0000

ARG 459 GLU 460 -0.0003

GLU 460 LEU 461 0.0001

LEU 461 MET 462 0.0003

MET 462 GLU 463 0.0023

GLU 463 ARG 464 0.0001

ARG 464 LEU 465 0.0003

LEU 465 ASN 466 0.0001

ASN 466 LYS 467 0.0003

LYS 467 THR 468 -0.0002

THR 468 GLY 469 0.0001

GLY 469 LYS 470 -0.0001

LYS 470 ALA 471 0.0002

ALA 471 TYR 472 0.0000

TYR 472 VAL 473 0.0131

VAL 473 ALA 474 -0.0005

ALA 474 HIS 475 0.0002

HIS 475 THR 476 0.0003

THR 476 VAL 477 -0.0004

VAL 477 VAL 478 0.0001

VAL 478 GLY 479 0.0002

GLY 479 GLY 480 0.0001

GLY 480 ARG 481 0.0001

ARG 481 PHE 482 -0.0002

PHE 482 VAL 483 0.0038

VAL 483 LEU 484 0.0001

LEU 484 ARG 485 0.0002

ARG 485 PHE 486 -0.0000

PHE 486 ALA 487 0.0000

ALA 487 VAL 488 0.0003

VAL 488 GLY 489 -0.0001

GLY 489 SER 490 0.0001

SER 490 SER 491 0.0004

SER 491 LEU 492 0.0001

LEU 492 GLN 493 0.0152

GLN 493 GLU 494 0.0003

GLU 494 GLU 495 -0.0004

GLU 495 HIS 496 0.0002

HIS 496 HIS 497 0.0001

HIS 497 VAL 498 -0.0001

VAL 498 ARG 499 -0.0000

ARG 499 SER 500 -0.0001

SER 500 ALA 501 0.0000

ALA 501 TRP 502 -0.0003

TRP 502 GLU 503 0.0103

GLU 503 LEU 504 -0.0003

LEU 504 ILE 505 -0.0001

ILE 505 LYS 506 -0.0003

LYS 506 LYS 507 0.0004

LYS 507 THR 508 0.0000

THR 508 THR 509 -0.0002

THR 509 THR 510 0.0002

THR 510 GLU 511 0.0000

GLU 511 MET 512 0.0005

MET 512 MET 513 -0.0029

MET 513 ASN 514 -0.0003

ASN 514 THR 21 0.0131

THR 21 PHE 22 0.0000

PHE 22 GLN 23 0.0004

GLN 23 PRO 24 0.0001

PRO 24 LEU 25 -0.0002

LEU 25 ASN 26 0.0001

ASN 26 ALA 27 0.0004

ALA 27 ASP 28 0.0002

ASP 28 ASP 29 0.0001

ASP 29 VAL 30 0.0001

VAL 30 ARG 31 0.0199

ARG 31 SER 32 -0.0002

SER 32 TYR 33 -0.0001

TYR 33 LEU 34 0.0003

LEU 34 HIS 35 0.0004

HIS 35 LYS 36 -0.0001

LYS 36 ALA 37 -0.0001

ALA 37 VAL 38 -0.0000

VAL 38 ASP 39 0.0001

ASP 39 PHE 40 -0.0003

PHE 40 ILE 41 0.0026

ILE 41 SER 42 -0.0001

SER 42 ASP 43 0.0001

ASP 43 TYR 44 -0.0001

TYR 44 TYR 45 0.0001

TYR 45 LYS 46 0.0000

LYS 46 SER 47 0.0001

SER 47 VAL 48 0.0005

VAL 48 GLU 49 -0.0002

GLU 49 SER 50 0.0000

SER 50 MET 51 -0.0138

MET 51 PRO 52 -0.0002

PRO 52 VAL 53 -0.0004

VAL 53 LEU 54 -0.0000

LEU 54 PRO 55 -0.0000

PRO 55 ASN 56 -0.0001

ASN 56 VAL 57 -0.0000

VAL 57 LYS 58 -0.0000

LYS 58 PRO 59 0.0001

PRO 59 GLY 60 0.0000

GLY 60 TYR 61 -0.0218

TYR 61 LEU 62 -0.0002

LEU 62 GLN 63 0.0001

GLN 63 ASP 64 0.0004

ASP 64 GLU 65 -0.0003

GLU 65 LEU 66 0.0002

LEU 66 ARG 67 -0.0001

ARG 67 ALA 68 0.0002

ALA 68 SER 69 0.0002

SER 69 PRO 70 0.0001

PRO 70 PRO 71 -0.0054

PRO 71 THR 72 0.0004

THR 72 TYR 73 -0.0002

TYR 73 SER 74 -0.0003

SER 74 ALA 75 0.0001

ALA 75 PRO 76 0.0003

PRO 76 PHE 77 -0.0001

PHE 77 ASP 78 0.0000

ASP 78 VAL 79 0.0004

VAL 79 THR 80 -0.0004

THR 80 MET 81 0.0110

MET 81 LYS 82 -0.0002

LYS 82 GLU 83 0.0001

GLU 83 LEU 84 0.0001

LEU 84 ARG 85 -0.0003

ARG 85 SER 86 -0.0002

SER 86 SER 87 0.0003

SER 87 VAL 88 -0.0002

VAL 88 VAL 89 -0.0001

VAL 89 PRO 90 -0.0001

PRO 90 GLY 91 0.0016

GLY 91 MET 92 0.0003

MET 92 THR 93 -0.0004

THR 93 HIS 94 -0.0000

HIS 94 TRP 95 0.0002

TRP 95 ALA 96 -0.0004

ALA 96 SER 97 0.0003

SER 97 PRO 98 -0.0002

PRO 98 ASN 99 0.0000

ASN 99 PHE 100 -0.0005

PHE 100 PHE 101 0.0385

PHE 101 ALA 102 0.0000

ALA 102 PHE 103 -0.0005

PHE 103 PHE 104 -0.0000

PHE 104 PRO 105 -0.0000

PRO 105 SER 106 -0.0005

SER 106 THR 107 -0.0004

THR 107 ASN 108 -0.0001

ASN 108 SER 109 0.0003

SER 109 ALA 110 -0.0003

ALA 110 ALA 111 -0.0367

ALA 111 ALA 112 -0.0004

ALA 112 ILE 113 -0.0001

ILE 113 ALA 114 0.0002

ALA 114 GLY 115 -0.0002

GLY 115 ASP 116 -0.0001

ASP 116 LEU 117 0.0004

LEU 117 ILE 118 -0.0000

ILE 118 ALA 119 0.0002

ALA 119 SER 120 -0.0001

SER 120 ALA 121 0.0066

ALA 121 MET 122 0.0001

MET 122 ASN 123 -0.0002

ASN 123 THR 124 0.0001

THR 124 VAL 125 -0.0004

VAL 125 GLY 126 -0.0002

GLY 126 PHE 127 0.0001

PHE 127 THR 128 0.0001

THR 128 TRP 129 -0.0004

TRP 129 GLN 130 -0.0002

GLN 130 ALA 131 -0.0045

ALA 131 SER 132 -0.0003

SER 132 PRO 133 0.0002

PRO 133 ALA 134 0.0003

ALA 134 ALA 135 0.0001

ALA 135 THR 136 0.0003

THR 136 GLU 137 0.0001

GLU 137 MET 138 -0.0001

MET 138 GLU 139 0.0002

GLU 139 VAL 140 -0.0002

VAL 140 LEU 141 0.0068

LEU 141 ALA 142 0.0002

ALA 142 LEU 143 -0.0003

LEU 143 ASP 144 -0.0002

ASP 144 TRP 145 0.0001

TRP 145 LEU 146 0.0005

LEU 146 ALA 147 -0.0000

ALA 147 GLN 148 -0.0002

GLN 148 MET 149 0.0002

MET 149 LEU 150 -0.0002

LEU 150 ASN 151 -0.0176

ASN 151 LEU 152 -0.0001

LEU 152 PRO 153 -0.0000

PRO 153 THR 154 0.0002

THR 154 SER 155 0.0000

SER 155 PHE 156 0.0005

PHE 156 MET 157 -0.0003

MET 157 ASN 158 -0.0000

ASN 158 ARG 159 0.0002

ARG 159 THR 160 -0.0001

THR 160 GLY 161 -0.0079

GLY 161 GLU 162 -0.0000

GLU 162 GLY 163 -0.0000

GLY 163 ARG 164 -0.0001

ARG 164 GLY 165 -0.0002

GLY 165 THR 166 -0.0000

THR 166 GLY 167 0.0003

GLY 167 GLY 168 0.0002

GLY 168 GLY 169 0.0000

GLY 169 VAL 170 -0.0003

VAL 170 ILE 171 0.0016

ILE 171 LEU 172 -0.0002

LEU 172 GLY 173 0.0001

GLY 173 THR 174 -0.0002

THR 174 THR 175 -0.0001

THR 175 SER 176 0.0002

SER 176 GLU 177 0.0001

GLU 177 ALA 178 0.0003

ALA 178 MET 179 -0.0002

MET 179 LEU 180 -0.0002

LEU 180 VAL 181 -0.0000

VAL 181 THR 182 -0.0001

THR 182 LEU 183 -0.0002

LEU 183 VAL 184 0.0001

VAL 184 ALA 185 -0.0005

ALA 185 ALA 186 -0.0002

ALA 186 ARG 187 0.0001

ARG 187 ASP 188 0.0000

ASP 188 ALA 189 0.0002

ALA 189 ALA 190 -0.0001

ALA 190 LEU 191 0.0123

LEU 191 ARG 192 -0.0001

ARG 192 ARG 193 -0.0002

ARG 193 SER 194 0.0003

SER 194 GLY 195 -0.0004

GLY 195 SER 196 -0.0002

SER 196 ASP 197 0.0001

ASP 197 GLY 198 0.0002

GLY 198 VAL 199 -0.0000

VAL 199 ALA 200 0.0000

ALA 200 GLY 201 -0.0202

GLY 201 LEU 202 -0.0002

LEU 202 HIS 203 -0.0002

HIS 203 ARG 204 -0.0003

ARG 204 LEU 205 -0.0001

LEU 205 ALA 206 0.0001

ALA 206 VAL 207 -0.0001

VAL 207 TYR 208 0.0003

TYR 208 ALA 209 -0.0006

ALA 209 ALA 210 0.0001

ALA 210 ASP 211 0.0129

ASP 211 GLN 212 -0.0001

GLN 212 THR 213 0.0001

THR 213 HIS 214 0.0002

HIS 214 SER 215 -0.0001

SER 215 THR 216 -0.0002

THR 216 PHE 217 -0.0001

PHE 217 PHE 218 -0.0003

PHE 218 LYS 219 0.0000

LYS 219 ALA 220 -0.0003

ALA 220 CYS 221 0.0008

CYS 221 ARG 222 -0.0001

ARG 222 LEU 223 -0.0001

LEU 223 ALA 224 -0.0001

ALA 224 GLY 225 -0.0001

GLY 225 PHE 226 0.0001

PHE 226 ASP 227 0.0001

ASP 227 PRO 228 -0.0006

PRO 228 ALA 229 -0.0002

ALA 229 ASN 230 0.0003

ASN 230 ILE 231 -0.0077

ILE 231 ARG 232 -0.0001

ARG 232 SER 233 -0.0000

SER 233 ILE 234 0.0002

ILE 234 PRO 235 -0.0002

PRO 235 THR 236 0.0002

THR 236 GLY 237 0.0002

GLY 237 ALA 238 -0.0005

ALA 238 GLU 239 0.0004

GLU 239 THR 240 -0.0000

THR 240 ASP 241 0.0024

ASP 241 TYR 242 0.0001

TYR 242 GLY 243 0.0002

GLY 243 LEU 244 0.0001

LEU 244 ASP 245 0.0004

ASP 245 PRO 246 -0.0001

PRO 246 ALA 247 0.0003

ALA 247 ARG 248 0.0002

ARG 248 LEU 249 -0.0001

LEU 249 LEU 250 0.0003

LEU 250 GLU 251 -0.0040

GLU 251 ALA 252 0.0004

ALA 252 MET 253 0.0001

MET 253 GLN 254 0.0002

GLN 254 ALA 255 -0.0002

ALA 255 ASP 256 -0.0002

ASP 256 ALA 257 -0.0002

ALA 257 ASP 258 0.0003

ASP 258 ALA 259 0.0001

ALA 259 GLY 260 0.0004

GLY 260 LEU 261 -0.0003

LEU 261 VAL 262 0.0001

VAL 262 PRO 263 0.0003

PRO 263 THR 264 -0.0002

THR 264 TYR 265 0.0004

TYR 265 VAL 266 -0.0000

VAL 266 CYS 267 0.0000

CYS 267 ALA 268 0.0004

ALA 268 THR 269 -0.0002

THR 269 VAL 270 0.0002

VAL 270 GLY 271 0.0066

GLY 271 THR 272 0.0002

THR 272 THR 273 0.0001

THR 273 SER 274 0.0004

SER 274 SER 275 0.0002

SER 275 ASN 276 0.0002

ASN 276 ALA 277 -0.0001

ALA 277 VAL 278 0.0002

VAL 278 ASP 279 0.0003

ASP 279 PRO 280 0.0002

PRO 280 VAL 281 -0.0157

VAL 281 GLY 282 0.0002

GLY 282 ALA 283 -0.0002

ALA 283 VAL 284 -0.0002

VAL 284 ALA 285 -0.0001

ALA 285 ASP 286 0.0003

ASP 286 VAL 287 0.0001

VAL 287 ALA 288 -0.0000

ALA 288 ALA 289 0.0002

ALA 289 ARG 290 -0.0004

ARG 290 PHE 291 -0.0021

PHE 291 ALA 292 -0.0000

ALA 292 ALA 293 -0.0001

ALA 293 TRP 294 0.0002

TRP 294 VAL 295 -0.0004

VAL 295 HIS 296 0.0002

HIS 296 VAL 297 -0.0000

VAL 297 ASP 298 0.0001

ASP 298 ALA 299 0.0002

ALA 299 ALA 300 0.0004

ALA 300 TYR 301 0.0027

TYR 301 ALA 302 0.0002

ALA 302 GLY 303 0.0004

GLY 303 SER 304 0.0002

SER 304 ALA 305 0.0000

ALA 305 CYS 306 0.0003

CYS 306 ILE 307 -0.0004

ILE 307 CYS 308 0.0002

CYS 308 PRO 309 -0.0001

PRO 309 GLU 310 0.0003

GLU 310 PHE 311 -0.0074

PHE 311 ARG 312 -0.0003

ARG 312 HIS 313 -0.0000

HIS 313 HIS 314 0.0002

HIS 314 LEU 315 -0.0002

LEU 315 ASP 316 0.0003

ASP 316 GLY 317 0.0000

GLY 317 VAL 318 0.0005

VAL 318 GLU 319 -0.0000

GLU 319 ARG 320 0.0003

ARG 320 VAL 321 0.0111

VAL 321 ASP 322 0.0000

ASP 322 SER 323 0.0002

SER 323 ILE 324 -0.0001

ILE 324 SER 325 0.0001

SER 325 MET 326 -0.0000

MET 326 SER 327 0.0001

SER 327 PRO 328 0.0001

PRO 328 HIS 329 0.0002

HIS 329 LYS 330 -0.0002

LYS 330 TRP 331 -0.0085

TRP 331 LEU 332 -0.0001

LEU 332 MET 333 0.0000

MET 333 THR 334 0.0003

THR 334 CYS 335 -0.0002

CYS 335 LEU 336 0.0002

LEU 336 ASP 337 -0.0006

ASP 337 CYS 338 0.0002

CYS 338 THR 339 0.0000

THR 339 CYS 340 -0.0001

CYS 340 LEU 341 0.0158

LEU 341 TYR 342 -0.0001

TYR 342 VAL 343 0.0000

VAL 343 ARG 344 -0.0002

ARG 344 ASP 345 -0.0000

ASP 345 THR 346 0.0003

THR 346 HIS 347 -0.0003

HIS 347 ARG 348 0.0003

ARG 348 LEU 349 0.0000

LEU 349 GLY 368 -0.0125

GLY 368 GLU 369 -0.0003

GLU 369 VAL 370 0.0005

VAL 370 THR 371 -0.0001

THR 371 ASP 372 0.0002

ASP 372 LEU 373 -0.0002

LEU 373 LYS 374 -0.0001

LYS 374 ASP 375 -0.0001

ASP 375 MET 376 0.0002

MET 376 GLN 377 0.0001

GLN 377 VAL 378 -0.0023

VAL 378 GLY 379 0.0005

GLY 379 VAL 380 -0.0004

VAL 380 GLY 381 -0.0000

GLY 381 ARG 382 0.0002

ARG 382 ARG 383 -0.0003

ARG 383 PHE 384 0.0000

PHE 384 ARG 385 0.0004

ARG 385 GLY 386 -0.0003

GLY 386 LEU 387 -0.0002

LEU 387 LYS 388 0.0192

LYS 388 LEU 389 0.0002

LEU 389 TRP 390 -0.0001

TRP 390 MET 391 -0.0004

MET 391 VAL 392 0.0002

VAL 392 MET 393 0.0004

MET 393 ARG 394 0.0004

ARG 394 THR 395 0.0002

THR 395 TYR 396 0.0002

TYR 396 GLY 397 0.0001

GLY 397 VAL 398 -0.0057

VAL 398 ALA 399 -0.0000

ALA 399 LYS 400 -0.0002

LYS 400 LEU 401 0.0003

LEU 401 GLN 402 -0.0004

GLN 402 GLU 403 -0.0001

GLU 403 HIS 404 -0.0005

HIS 404 ILE 405 0.0002

ILE 405 ARG 406 -0.0002

ARG 406 SER 407 0.0000

SER 407 ASP 408 -0.0801

ASP 408 VAL 409 0.0001

VAL 409 ALA 410 0.0003

ALA 410 MET 411 0.0000

MET 411 ALA 412 -0.0001

ALA 412 LYS 413 0.0001

LYS 413 VAL 414 -0.0001

VAL 414 PHE 415 -0.0001

PHE 415 GLU 416 -0.0002

GLU 416 ASP 417 0.0002

ASP 417 LEU 418 -0.0231

LEU 418 VAL 419 0.0004

VAL 419 ARG 420 -0.0001

ARG 420 GLY 421 0.0000

GLY 421 ASP 422 0.0001

ASP 422 ASP 423 0.0002

ASP 423 ARG 424 -0.0002

ARG 424 PHE 425 -0.0002

PHE 425 GLU 426 -0.0000

GLU 426 VAL 427 0.0000

VAL 427 VAL 428 0.0219

VAL 428 VAL 429 0.0002

VAL 429 PRO 430 0.0002

PRO 430 ARG 431 0.0001

ARG 431 ASN 432 -0.0001

ASN 432 PHE 433 -0.0003

PHE 433 ALA 434 -0.0002

ALA 434 LEU 435 0.0001

LEU 435 VAL 436 -0.0001

VAL 436 CYS 437 0.0003

CYS 437 PHE 438 -0.0309

PHE 438 ARG 439 0.0001

ARG 439 ILE 440 -0.0001

ILE 440 ARG 441 0.0000

ARG 441 ALA 442 0.0002

ALA 442 GLY 443 -0.0003

GLY 443 ALA 444 0.0002

ALA 444 GLY 445 0.0001

GLY 445 ALA 446 0.0001

ALA 446 ALA 447 0.0003

ALA 447 ALA 448 0.0070

ALA 448 ALA 449 -0.0002

ALA 449 THR 450 0.0000

THR 450 GLU 451 0.0004

GLU 451 GLU 452 -0.0000

GLU 452 ASP 453 0.0002

ASP 453 ALA 454 0.0001

ALA 454 ASP 455 -0.0001

ASP 455 GLU 456 -0.0000

GLU 456 ALA 457 0.0002

ALA 457 ASN 458 0.0053

ASN 458 ARG 459 -0.0000

ARG 459 GLU 460 0.0003

GLU 460 LEU 461 -0.0002

LEU 461 MET 462 0.0002

MET 462 GLU 463 0.0000

GLU 463 ARG 464 0.0003

ARG 464 LEU 465 0.0001

LEU 465 ASN 466 -0.0003

ASN 466 LYS 467 -0.0002

LYS 467 THR 468 -0.0186

THR 468 GLY 469 0.0003

GLY 469 LYS 470 0.0001

LYS 470 ALA 471 -0.0001

ALA 471 TYR 472 -0.0001

TYR 472 VAL 473 0.0002

VAL 473 ALA 474 0.0002

ALA 474 HIS 475 -0.0001

HIS 475 THR 476 -0.0002

THR 476 VAL 477 0.0002

VAL 477 VAL 478 0.0140

VAL 478 GLY 479 0.0001

GLY 479 GLY 480 -0.0003

GLY 480 ARG 481 0.0002

ARG 481 PHE 482 -0.0003

PHE 482 VAL 483 0.0004

VAL 483 LEU 484 0.0001

LEU 484 ARG 485 -0.0002

ARG 485 PHE 486 0.0004

PHE 486 ALA 487 -0.0002

ALA 487 VAL 488 -0.0209

VAL 488 GLY 489 -0.0002

GLY 489 SER 490 0.0001

SER 490 SER 491 0.0000

SER 491 LEU 492 -0.0001

LEU 492 GLN 493 -0.0001

GLN 493 GLU 494 -0.0002

GLU 494 GLU 495 0.0004

GLU 495 HIS 496 -0.0000

HIS 496 HIS 497 0.0003

HIS 497 VAL 498 0.0163

VAL 498 ARG 499 -0.0001

ARG 499 SER 500 -0.0002

SER 500 ALA 501 -0.0002

ALA 501 TRP 502 0.0002

TRP 502 GLU 503 -0.0000

GLU 503 LEU 504 -0.0004

LEU 504 ILE 505 0.0003

ILE 505 LYS 506 -0.0002

LYS 506 LYS 507 -0.0001

LYS 507 THR 508 -0.0005

THR 508 THR 509 0.0002

THR 509 THR 510 0.0003

THR 510 GLU 511 0.0001

GLU 511 MET 512 -0.0001

MET 512 MET 513 0.0003

MET 513 ASN 514 0.0001

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: April 8th, 2025.

Should you encounter any unexpected behaviour, please let us know.

*** LYASE 16-Jul-19 6KHP ***

CA strain for 2502122039304104175

--- normal mode 11 ---

Should you encounter any unexpected behaviour,
please let us know.

* LYASE 16-Jul-19 6KHP *