Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *

CA strain for 22101813491974862

--- normal mode 29 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
ASN 989 LYS 990 0.1221

LYS 990 ALA 991 0.1336

ALA 991 HIS 992 0.1107

HIS 992 ARG 993 0.0802

ARG 993 GLN 994 0.1335

GLN 994 ARG 995 0.1326

ARG 995 VAL 996 0.0799

VAL 996 HIS 997 0.1258

HIS 997 PRO 998 0.1211

PRO 998 PRO 999 0.1178

PRO 999 HIS 1000 0.1229

HIS 1000 ASP 1001 0.1188

ASP 1001 LEU 1002 0.0906

LEU 1002 LEU 1003 0.0589

LEU 1003 GLY 1004 0.1343

GLY 1004 SER 1005 0.0957

SER 1005 LEU 1006 0.0453

LEU 1006 ILE 1007 0.0083

ILE 1007 VAL 1008 0.0605

VAL 1008 GLY 1009 0.0167

GLY 1009 ARG 1010 0.0700

ARG 1010 ASP 1011 0.0702

ASP 1011 LEU 1012 0.0093

LEU 1012 ARG 1013 0.0657

ARG 1013 GLU 1014 0.0700

GLU 1014 PRO 1015 0.0427

PRO 1015 THR 1016 0.0697

THR 1016 TRP 1017 0.0319

TRP 1017 ARG 1018 0.0698

ARG 1018 HIS 1019 0.0283

HIS 1019 PHE 1020 0.0700

PHE 1020 ILE 1021 -0.0255

ILE 1021 ARG 1022 0.0552

ARG 1022 VAL 1023 0.0348

VAL 1023 GLN 1024 0.0579

GLN 1024 ASP 1025 0.0802

ASP 1025 ILE 1026 0.0810

ILE 1026 PRO 1027 0.0521

PRO 1027 TRP 1028 0.0808

TRP 1028 ILE 1029 0.0121

ILE 1029 ARG 1030 0.0701

ARG 1030 ASP 1031 0.0660

ASP 1031 HIS 1032 0.0232

HIS 1032 VAL 1033 0.0670

VAL 1033 VAL 1034 0.0441

VAL 1034 GLN 1035 0.0740

GLN 1035 SER 1036 0.0652

SER 1036 ALA 1037 0.0375

ALA 1037 LEU 1038 0.0603

LEU 1038 VAL 1039 0.0564

VAL 1039 TYR 1040 0.0675

TYR 1040 PRO 1041 0.0582

PRO 1041 GLY 1042 0.0409

GLY 1042 ALA 1043 0.0392

ALA 1043 GLY 1044 0.0661

GLY 1044 PHE 1045 0.0075

PHE 1045 ILE 1046 0.0609

ILE 1046 CYS 1047 0.0381

CYS 1047 MET 1048 0.0333

MET 1048 ALA 1049 0.0494

ALA 1049 MET 1050 0.0278

MET 1050 GLU 1051 0.0652

GLU 1051 ALA 1052 0.0041

ALA 1052 MET 1053 0.0347

MET 1053 VAL 1054 0.0285

VAL 1054 GLN 1055 0.0704

GLN 1055 LEU 1056 0.0400

LEU 1056 HIS 1057 0.0544

HIS 1057 GLU 1058 0.0722

GLU 1058 LEU 1059 0.0212

LEU 1059 ARG 1060 0.0817

ARG 1060 ASP 1061 0.0382

ASP 1061 SER 1062 0.0689

SER 1062 GLN 1063 0.0757

GLN 1063 SER 1064 0.0360

SER 1064 ARG 1065 0.0864

ARG 1065 LYS 1066 0.0471

LYS 1066 VAL 1067 0.0779

VAL 1067 ALA 1068 0.0806

ALA 1068 GLY 1069 0.0984

GLY 1069 TYR 1070 0.0350

TYR 1070 ARG 1071 0.0393

ARG 1071 LEU 1072 0.0481

LEU 1072 ALA 1073 0.0347

ALA 1073 GLU 1074 0.0443

GLU 1074 VAL 1075 0.0438

VAL 1075 ASP 1076 0.0540

ASP 1076 ILE 1077 0.0481

ILE 1077 LEU 1078 0.0245

LEU 1078 ARG 1079 0.0509

ARG 1079 ALA 1080 0.0130

ALA 1080 MET 1081 0.0608

MET 1081 LEU 1082 0.0534

LEU 1082 ILE 1083 0.0423

ILE 1083 PRO 1084 0.0613

PRO 1084 ASP 1085 0.0240

ASP 1085 THR 1086 0.0418

THR 1086 SER 1087 0.0564

SER 1087 GLU 1088 0.0170

GLU 1088 GLY 1089 0.0522

GLY 1089 LEU 1090 0.0368

LEU 1090 GLU 1091 0.0399

GLU 1091 ALA 1092 0.0552

ALA 1092 HIS 1093 0.0462

HIS 1093 ILE 1094 0.0543

ILE 1094 SER 1095 0.0297

SER 1095 LEU 1096 0.0560

LEU 1096 ARG 1097 0.0224

ARG 1097 PRO 1098 0.0565

PRO 1098 CYS 1099 0.0548

CYS 1099 SER 1100 0.0151

SER 1100 THR 1101 0.0383

THR 1101 LYS 1102 0.0284

LYS 1102 LEU 1103 0.0084

LEU 1103 LEU 1104 0.0339

LEU 1104 LEU 1105 0.0091

LEU 1105 THR 1106 0.0342

THR 1106 ASN 1107 0.0187

ASN 1107 GLU 1108 0.0344

GLU 1108 TRP 1109 0.0277

TRP 1109 TYR 1110 0.0323

TYR 1110 ASP 1111 0.0341

ASP 1111 PHE 1112 0.0107

PHE 1112 CYS 1113 0.0326

CYS 1113 VAL 1114 0.0080

VAL 1114 SER 1115 0.0343

SER 1115 SER 1116 0.0248

SER 1116 VAL 1117 0.0331

VAL 1117 GLY 1118 0.0491

GLY 1118 ASP 1119 0.0473

ASP 1119 ASP 1120 0.0050

ASP 1120 ASP 1121 0.0487

ASP 1121 LYS 1122 0.0491

LYS 1122 PHE 1123 0.0397

PHE 1123 VAL 1124 0.0313

VAL 1124 ASP 1125 0.0469

ASP 1125 HIS 1126 0.0035

HIS 1126 CYS 1127 0.0490

CYS 1127 ARG 1128 0.0321

ARG 1128 GLY 1129 0.0482

GLY 1129 ARG 1130 0.0489

ARG 1130 ILE 1131 0.0340

ILE 1131 THR 1132 0.0494

THR 1132 ILE 1133 0.1200

ILE 1133 GLU 1134 0.0621

GLU 1134 PHE 1135 0.0459

PHE 1135 ASP 1136 0.0426

ASP 1136 THR 1137 0.0451

THR 1137 SER 1138 0.0445

SER 1138 GLY 1139 0.0501

GLY 1139 SER 1140 0.0585

SER 1140 ALA 1141 0.0417

ALA 1141 ASP 1142 0.0634

ASP 1142 THR 1143 0.0203

THR 1143 PRO 1144 0.0401

PRO 1144 ARG 1145 0.0641

ARG 1145 THR 1146 0.0651

THR 1146 SER 1147 0.0139

SER 1147 LEU 1148 0.0647

LEU 1148 ARG 1149 0.1568

ARG 1149 GLU 1150 0.0204

GLU 1150 ARG 1151 0.0073

ARG 1151 SER 1152 0.0173

SER 1152 ARG 1153 0.0135

ARG 1153 SER 1154 0.0149

SER 1154 THR 1155 0.0171

THR 1155 GLY 1156 0.0177

GLY 1156 LEU 1157 0.0204

LEU 1157 MET 1158 0.0183

MET 1158 ARG 1159 0.0188

ARG 1159 SER 1160 0.0212

SER 1160 VAL 1161 0.0062

VAL 1161 ASP 1162 0.0207

ASP 1162 PRO 1163 0.0105

PRO 1163 SER 1164 0.0187

SER 1164 ASN 1165 0.5086

ASN 1165 LEU 1166 0.0092

LEU 1166 TYR 1167 0.0570

TYR 1167 SER 1168 0.0496

SER 1168 PHE 1169 0.0257

PHE 1169 LEU 1170 0.0296

LEU 1170 ARG 1171 0.0496

ARG 1171 ALA 1172 0.0570

ALA 1172 GLN 1173 0.0053

GLN 1173 GLY 1174 0.0561

GLY 1174 ILE 1175 0.0566

ILE 1175 TYR 1176 0.0238

TYR 1176 HIS 1177 0.0523

HIS 1177 GLY 1178 0.0290

GLY 1178 PRO 1179 0.0254

PRO 1179 ILE 1180 0.0409

ILE 1180 PHE 1181 0.0002

PHE 1181 GLN 1182 0.0335

GLN 1182 ASN 1183 0.0555

ASN 1183 LEU 1184 0.0564

LEU 1184 LYS 1185 0.0157

LYS 1185 THR 1186 0.0545

THR 1186 ILE 1187 0.0252

ILE 1187 SER 1188 0.0558

SER 1188 SER 1189 0.0188

SER 1189 ARG 1190 0.0414

ARG 1190 LYS 1191 0.0145

LYS 1191 ASP 1192 0.0382

ASP 1192 HIS 1193 0.0359

HIS 1193 SER 1194 0.0211

SER 1194 GLU 1195 0.0333

GLU 1195 SER 1196 0.0502

SER 1196 SER 1197 0.0132

SER 1197 PHE 1198 0.0851

PHE 1198 VAL 1199 0.0713

VAL 1199 VAL 1200 0.0721

VAL 1200 ALA 1201 0.0832

ALA 1201 ASN 1202 0.0703

ASN 1202 THR 1203 0.0307

THR 1203 ALA 1204 0.0776

ALA 1204 SER 1205 0.0383

SER 1205 VAL 1206 0.0540

VAL 1206 MET 1207 0.0613

MET 1207 PRO 1208 0.0823

PRO 1208 ASN 1209 0.0418

ASN 1209 GLY 1210 0.0853

GLY 1210 PHE 1211 0.0333

PHE 1211 GLN 1212 0.0440

GLN 1212 SER 1213 0.0414

SER 1213 PRO 1214 0.0742

PRO 1214 HIS 1215 0.0596

HIS 1215 VAL 1216 0.0736

VAL 1216 ILE 1217 0.0706

ILE 1217 HIS 1218 0.0721

HIS 1218 PRO 1219 0.0567

PRO 1219 THR 1220 0.0213

THR 1220 THR 1221 0.0709

THR 1221 LEU 1222 0.0151

LEU 1222 ASP 1223 0.0754

ASP 1223 SER 1224 0.0161

SER 1224 ILE 1225 0.0617

ILE 1225 PHE 1226 0.0360

PHE 1226 GLN 1227 0.0401

GLN 1227 GLY 1228 0.0656

GLY 1228 ALA 1229 -0.0260

ALA 1229 TYR 1230 0.0483

TYR 1230 THR 1231 0.0257

THR 1231 ALA 1232 0.0309

ALA 1232 LEU 1233 0.0475

LEU 1233 PRO 1234 0.0468

PRO 1234 GLY 1235 0.0098

GLY 1235 ALA 1236 0.0530

ALA 1236 GLY 1237 0.0343

GLY 1237 LEU 1238 0.0348

LEU 1238 ASP 1239 0.0300

ASP 1239 GLN 1240 0.0244

GLN 1240 ASN 1241 0.0401

ASN 1241 THR 1242 0.0472

THR 1242 ALA 1243 0.0508

ALA 1243 MET 1244 0.0419

MET 1244 ILE 1245 0.0050

ILE 1245 PRO 1246 0.0567

PRO 1246 ARG 1247 0.0001

ARG 1247 SER 1248 0.0587

SER 1248 ILE 1249 0.0551

ILE 1249 GLN 1250 0.0448

GLN 1250 GLU 1251 0.0449

GLU 1251 LEU 1252 0.0201

LEU 1252 TYR 1253 0.0500

TYR 1253 LEU 1254 0.0263

LEU 1254 SER 1255 0.0471

SER 1255 SER 1256 0.0572

SER 1256 ALA 1257 0.0157

ALA 1257 LEU 1258 0.0607

LEU 1258 THR 1259 0.0310

THR 1259 SER 1260 0.0624

SER 1260 ASP 1261 -0.1067

ASP 1261 VAL 1262 0.0666

VAL 1262 GLY 1263 0.0712

GLY 1263 GLN 1264 0.0588

GLN 1264 CYS 1265 0.0691

CYS 1265 LEU 1266 0.0059

LEU 1266 VAL 1267 0.0644

VAL 1267 SER 1268 0.0088

SER 1268 ASP 1269 0.0539

ASP 1269 THR 1270 0.0341

THR 1270 SER 1271 0.0309

SER 1271 LEU 1272 0.0478

LEU 1272 ILE 1273 0.0076

ILE 1273 ARG 1274 0.0646

ARG 1274 TYR 1275 0.0720

TYR 1275 ASP 1276 0.0511

ASP 1276 GLY 1277 -0.0605

GLY 1277 GLN 1278 0.0486

GLN 1278 SER 1279 0.0588

SER 1279 PHE 1280 0.0476

PHE 1280 THR 1281 0.0581

THR 1281 VAL 1282 0.0288

VAL 1282 ASN 1283 0.0570

ASN 1283 VAL 1284 0.0146

VAL 1284 ASP 1285 0.0461

ASP 1285 VAL 1286 0.0199

VAL 1286 SER 1287 0.0310

SER 1287 SER 1288 0.0117

SER 1288 LYS 1289 0.0283

LYS 1289 ALA 1290 0.0460

ALA 1290 ASP 1291 0.0264

ASP 1291 SER 1292 0.0576

SER 1292 GLU 1293 -0.1029

GLU 1293 HIS 1294 0.0531

HIS 1294 THR 1295 0.0259

THR 1295 PRO 1296 0.0403

PRO 1296 VAL 1297 0.0594

VAL 1297 LEU 1298 0.0341

LEU 1298 GLU 1299 0.0287

GLU 1299 ILE 1300 0.0396

ILE 1300 LYS 1301 0.0239

LYS 1301 GLY 1302 0.0465

GLY 1302 LEU 1303 0.0427

LEU 1303 ARG 1304 0.0449

ARG 1304 ASN 1305 0.0479

ASN 1305 GLN 1306 0.0420

GLN 1306 SER 1307 0.0573

SER 1307 VAL 1308 0.0594

VAL 1308 GLY 1309 -0.0778

GLY 1309 GLN 1310 0.1241

GLN 1310 MET 1311 0.1018

MET 1311 ALA 1312 0.0777

ALA 1312 PRO 1313 0.1209

PRO 1313 GLN 1314 0.0943

GLN 1314 PRO 1315 0.0927

PRO 1315 GLY 1316 0.1160

GLY 1316 ASP 1317 0.1234

ASP 1317 SER 1318 0.0115

SER 1318 SER 1319 0.1250

SER 1319 ASN 1320 0.1208

ASN 1320 ASN 1321 0.0144

ASN 1321 ASP 1322 0.1256

ASP 1322 LEU 1323 0.1076

LEU 1323 CYS 1324 0.0754

CYS 1324 PHE 1325 -0.1089

PHE 1325 LYS 1326 0.0072

LYS 1326 LEU 1327 0.0212

LEU 1327 ASP 1328 0.0442

ASP 1328 TRP 1329 0.0135

TRP 1329 ALA 1330 0.0466

ALA 1330 PRO 1331 0.0274

PRO 1331 ASP 1332 0.0457

ASP 1332 ILE 1333 0.0450

ILE 1333 SER 1334 0.0412

SER 1334 SER 1335 0.0070

SER 1335 VAL 1336 0.0467

VAL 1336 LYS 1337 0.0207

LYS 1337 GLN 1338 0.0450

GLN 1338 GLU 1339 0.0246

GLU 1339 ARG 1340 0.0393

ARG 1340 LEU 1341 -0.1842

LEU 1341 LYS 1342 0.0122

LYS 1342 GLU 1343 0.0447

GLU 1343 LYS 1344 0.0109

LYS 1344 PHE 1345 0.0461

PHE 1345 GLY 1346 0.0031

GLY 1346 PHE 1347 0.0454

PHE 1347 PRO 1348 0.0254

PRO 1348 LEU 1349 0.0257

LEU 1349 ASP 1350 0.0461

ASP 1350 PRO 1351 0.0177

PRO 1351 THR 1352 0.0445

THR 1352 GLU 1353 0.0491

GLU 1353 ALA 1354 0.0084

ALA 1354 ASP 1355 0.0437

ASP 1355 ILE 1356 0.0381

ILE 1356 ILE 1357 0.0843

ILE 1357 MET 1358 0.0077

MET 1358 GLY 1359 0.1868

GLY 1359 LEU 1360 0.1100

LEU 1360 ARG 1361 0.1202

ARG 1361 GLN 1362 0.1157

GLN 1362 ALA 1363 0.1140

ALA 1363 CYS 1364 0.1802

CYS 1364 ILE 1365 0.0236

ILE 1365 HIS 1366 0.1904

HIS 1366 PHE 1367 0.0738

PHE 1367 ILE 1368 0.1792

ILE 1368 HIS 1369 0.0253

HIS 1369 ARG 1370 0.1773

ARG 1370 SER 1371 0.1121

SER 1371 LEU 1372 0.1227

LEU 1372 GLN 1373 0.1540

GLN 1373 SER 1374 0.1255

SER 1374 LEU 1375 0.1695

LEU 1375 THR 1376 0.1970

THR 1376 ALA 1377 0.2108

ALA 1377 PRO 1378 0.0716

PRO 1378 ASP 1379 0.1806

ASP 1379 ARG 1380 0.2043

ARG 1380 ASP 1381 0.1824

ASP 1381 GLN 1382 0.0680

GLN 1382 LEU 1383 0.2093

LEU 1383 ASP 1384 0.0699

ASP 1384 TRP 1385 0.2094

TRP 1385 HIS 1386 0.2092

HIS 1386 GLN 1387 0.1374

GLN 1387 LYS 1388 0.1320

LYS 1388 ARG 1389 0.3641

ARG 1389 PHE 1390 0.1874

PHE 1390 TYR 1391 0.0803

TYR 1391 ASP 1392 0.1681

ASP 1392 TRP 1393 0.1868

TRP 1393 MET 1394 0.1580

MET 1394 VAL 1395 0.0812

VAL 1395 LEU 1396 0.1908

LEU 1396 GLN 1397 0.1910

GLN 1397 ILE 1398 0.0799

ILE 1398 GLN 1399 0.1532

GLN 1399 LEU 1400 0.1824

LEU 1400 ALA 1401 0.1750

ALA 1401 GLU 1402 0.0566

GLU 1402 GLU 1403 0.1894

GLU 1403 ASP 1404 0.1885

ASP 1404 ARG 1405 0.2354

ARG 1405 LEU 1406 0.1114

LEU 1406 ALA 1407 0.2097

ALA 1407 PRO 1408 0.0450

PRO 1408 ASN 1409 0.2054

ASN 1409 SER 1410 0.1201

SER 1410 SER 1411 0.1474

SER 1411 ALA 1412 0.2407

ALA 1412 TRP 1413 0.0246

TRP 1413 LEU 1414 0.2339

LEU 1414 GLN 1415 0.1554

GLN 1415 CYS 1416 0.1693

CYS 1416 SER 1417 0.2438

SER 1417 SER 1418 0.0960

SER 1418 SER 1419 0.2422

SER 1419 ASP 1420 0.2441

ASP 1420 GLU 1421 0.2199

GLU 1421 GLN 1422 0.1120

GLN 1422 LYS 1423 0.2229

LYS 1423 LEU 1424 0.2230

LEU 1424 LEU 1425 0.0962

LEU 1425 GLU 1426 0.1757

GLU 1426 ASN 1427 0.2157

ASN 1427 VAL 1428 0.2132

VAL 1428 ARG 1429 0.0732

ARG 1429 ALA 1430 0.2125

ALA 1430 SER 1431 0.2099

SER 1431 SER 1432 0.1465

SER 1432 VAL 1433 0.1299

VAL 1433 ASN 1434 0.1203

ASN 1434 GLY 1435 0.1652

GLY 1435 GLN 1436 0.1006

GLN 1436 MET 1437 0.1474

MET 1437 VAL 1438 0.0216

VAL 1438 VAL 1439 0.2036

VAL 1439 HIS 1440 0.0672

HIS 1440 VAL 1441 0.2057

VAL 1441 GLY 1442 0.0017

GLY 1442 LYS 1443 0.2092

LYS 1443 SER 1444 0.1445

SER 1444 MET 1445 0.1716

MET 1445 LEU 1446 0.1750

LEU 1446 ALA 1447 0.0615

ALA 1447 ILE 1448 0.1740

ILE 1448 LEU 1449 0.1178

LEU 1449 ARG 1450 0.2054

ARG 1450 HIS 1451 0.0080

HIS 1451 GLU 1452 0.2046

GLU 1452 ILE 1453 0.1012

ILE 1453 ALA 1454 0.1825

ALA 1454 PRO 1455 0.1403

PRO 1455 LEU 1456 0.1109

LEU 1456 GLU 1457 0.1486

GLU 1457 LEU 1458 0.0811

LEU 1458 MET 1459 0.2005

MET 1459 LEU 1460 0.0218

LEU 1460 GLN 1461 0.2042

GLN 1461 ASP 1462 0.2034

ASP 1462 LYS 1463 0.2021

LYS 1463 LEU 1464 0.0026

LEU 1464 LEU 1465 0.2039

LEU 1465 TYR 1466 0.1483

TYR 1466 ARG 1467 0.1242

ARG 1467 TYR 1468 0.1036

TYR 1468 TYR 1469 -0.0233

TYR 1469 THR 1470 0.0312

THR 1470 ASP 1471 0.0272

ASP 1471 ALA 1472 0.0048

ALA 1472 ILE 1473 0.0219

ILE 1473 LYS 1474 0.0395

LYS 1474 TRP 1475 0.0089

TRP 1475 ASP 1476 0.0270

ASP 1476 ARG 1477 0.0267

ARG 1477 SER 1478 0.0393

SER 1478 TYR 1479 0.0009

TYR 1479 GLN 1480 0.0395

GLN 1480 GLN 1481 0.0294

GLN 1481 ILE 1482 0.0242

ILE 1482 ASP 1483 0.0150

ASP 1483 GLN 1484 0.0363

GLN 1484 LEU 1485 -0.3560

LEU 1485 VAL 1486 0.0068

VAL 1486 LYS 1487 0.0057

LYS 1487 LEU 1488 0.0097

LEU 1488 HIS 1489 0.0002

HIS 1489 ALA 1490 0.0096

ALA 1490 HIS 1491 0.0067

HIS 1491 LYS 1492 0.0061

LYS 1492 CYS 1493 0.0027

CYS 1493 PRO 1494 0.0095

PRO 1494 THR 1495 0.0005

THR 1495 ALA 1496 0.0096

ALA 1496 LYS 1497 0.0046

LYS 1497 ILE 1498 0.0076

ILE 1498 ILE 1499 0.0084

ILE 1499 GLU 1500 0.0071

GLU 1500 ILE 1501 -0.0090

ILE 1501 GLY 1502 0.0069

GLY 1502 ALA 1503 0.0009

ALA 1503 GLY 1504 0.0069

GLY 1504 THR 1505 0.0027

THR 1505 GLY 1506 0.0061

GLY 1506 GLY 1507 0.0067

GLY 1507 CYS 1508 0.0062

CYS 1508 THR 1509 0.0043

THR 1509 ARG 1510 0.0026

ARG 1510 ALA 1511 0.0063

ALA 1511 VAL 1512 0.0067

VAL 1512 LEU 1513 0.0017

LEU 1513 ASP 1514 0.0053

ASP 1514 ALA 1515 0.0051

ALA 1515 LEU 1516 0.0066

LEU 1516 SER 1517 0.2087

SER 1517 ASN 1518 0.0019

ASN 1518 GLN 1519 0.0008

GLN 1519 GLY 1520 0.0015

GLY 1520 ILE 1521 0.0002

ILE 1521 ALA 1522 0.0012

ALA 1522 ARG 1523 0.0008

ARG 1523 CYS 1524 0.0013

CYS 1524 ALA 1525 0.0012

ALA 1525 GLN 1526 0.0015

GLN 1526 TYR 1527 0.0012

TYR 1527 ASP 1528 0.0017

ASP 1528 PHE 1529 0.0005

PHE 1529 THR 1530 0.0017

THR 1530 ASP 1531 0.0014

ASP 1531 VAL 1532 0.0018

VAL 1532 SER 1533 0.1772

SER 1533 SER 1534 0.0041

SER 1534 GLY 1535 0.0077

GLY 1535 PHE 1536 0.0096

PHE 1536 PHE 1537 0.0096

PHE 1537 GLU 1538 0.0004

GLU 1538 ALA 1539 0.0095

ALA 1539 ALA 1540 0.0044

ALA 1540 GLN 1541 0.0072

GLN 1541 GLN 1542 0.0050

GLN 1542 LYS 1543 0.0052

LYS 1543 PHE 1544 0.0080

PHE 1544 ALA 1545 0.0044

ALA 1545 ALA 1546 0.0089

ALA 1546 PHE 1547 0.0036

PHE 1547 ASP 1548 0.0081

ASP 1548 ASP 1549 0.1060

ASP 1549 VAL 1550 0.0035

VAL 1550 ILE 1551 0.0054

ILE 1551 ARG 1552 0.0025

ARG 1552 PHE 1553 0.0052

PHE 1553 GLN 1554 0.0049

GLN 1554 LYS 1555 0.0058

LYS 1555 LEU 1556 0.0037

LEU 1556 ASP 1557 0.0054

ASP 1557 ILE 1558 0.0023

ILE 1558 GLU 1559 0.0055

GLU 1559 LYS 1560 0.0014

LYS 1560 ASP 1561 0.0053

ASP 1561 ILE 1562 0.0053

ILE 1562 GLU 1563 0.0028

GLU 1563 MET 1564 0.0029

MET 1564 GLN 1565 0.0531

GLN 1565 GLY 1566 0.0113

GLY 1566 PHE 1567 0.0026

PHE 1567 GLU 1568 0.0112

GLU 1568 CYS 1569 0.0027

CYS 1569 GLY 1570 0.0066

GLY 1570 SER 1571 0.0084

SER 1571 TYR 1572 0.0090

TYR 1572 ASP 1573 0.0052

ASP 1573 LEU 1574 0.0114

LEU 1574 VAL 1575 0.0123

VAL 1575 ILE 1576 0.0122

ILE 1576 ALA 1577 0.0120

ALA 1577 SER 1578 0.0114

SER 1578 GLN 1579 0.0121

GLN 1579 VAL 1580 0.0072

VAL 1580 LEU 1581 -0.1834

LEU 1581 HIS 1582 0.0276

HIS 1582 ALA 1583 0.0177

ALA 1583 THR 1584 0.0244

THR 1584 GLY 1585 0.0357

GLY 1585 LYS 1586 0.0374

LYS 1586 MET 1587 0.0250

MET 1587 GLU 1588 0.0349

GLU 1588 HIS 1589 0.0057

HIS 1589 THR 1590 0.0354

THR 1590 MET 1591 0.0287

MET 1591 ALA 1592 0.0170

ALA 1592 ASN 1593 0.0279

ASN 1593 VAL 1594 0.0178

VAL 1594 ARG 1595 0.0386

ARG 1595 LYS 1596 0.0022

LYS 1596 LEU 1597 0.1632

LEU 1597 LEU 1598 0.0092

LEU 1598 LYS 1599 0.0169

LYS 1599 PRO 1600 0.0087

PRO 1600 GLY 1601 0.0068

GLY 1601 GLY 1602 0.0144

GLY 1602 LYS 1603 0.0103

LYS 1603 LEU 1604 0.0168

LEU 1604 LEU 1605 0.0140

LEU 1605 LEU 1606 0.0157

LEU 1606 VAL 1607 0.0144

VAL 1607 GLU 1608 0.0160

GLU 1608 THR 1609 0.0107

THR 1609 THR 1610 0.0083

THR 1610 ARG 1611 0.0109

ARG 1611 ASP 1612 0.0145

ASP 1612 GLU 1613 0.2696

GLU 1613 MET 1614 0.1185

MET 1614 ASP 1615 0.0870

ASP 1615 LEU 1616 0.0534

LEU 1616 GLN 1617 0.1200

GLN 1617 LEU 1618 0.1285

LEU 1618 VAL 1619 0.0293

VAL 1619 PHE 1620 0.0953

PHE 1620 GLY 1621 0.0871

GLY 1621 LEU 1622 0.1270

LEU 1622 LEU 1623 0.0269

LEU 1623 PRO 1624 0.1320

PRO 1624 GLY 1625 0.1106

GLY 1625 TRP 1626 0.0374

TRP 1626 TRP 1627 0.1200

TRP 1627 LEU 1628 0.0599

LEU 1628 SER 1629 0.3007

SER 1629 SER 1630 0.1035

SER 1630 GLU 1631 0.0637

GLU 1631 GLU 1632 0.0126

GLU 1632 GLU 1633 0.0899

GLU 1633 ARG 1634 0.0682

ARG 1634 GLN 1635 0.1028

GLN 1635 MET 1636 0.0576

MET 1636 SER 1637 0.0839

SER 1637 PRO 1638 0.0170

PRO 1638 SER 1639 0.0889

SER 1639 LEU 1640 0.0995

LEU 1640 SER 1641 0.0464

SER 1641 THR 1642 0.0985

THR 1642 ASN 1643 0.0918

ASN 1643 SER 1644 0.0656

SER 1644 TRP 1645 0.4144

TRP 1645 GLU 1646 0.0371

GLU 1646 LYS 1647 0.0353

LYS 1647 VAL 1648 0.0111

VAL 1648 LEU 1649 0.0388

LEU 1649 LYS 1650 0.0394

LYS 1650 LYS 1651 0.0257

LYS 1651 THR 1652 0.0197

THR 1652 GLY 1653 0.0398

GLY 1653 PHE 1654 0.0201

PHE 1654 ASP 1655 0.0171

ASP 1655 GLY 1656 0.0234

GLY 1656 LEU 1657 0.0306

LEU 1657 ASP 1658 0.0399

ASP 1658 ILE 1659 0.0301

ILE 1659 GLU 1660 0.0318

GLU 1660 LEU 1661 0.0355

LEU 1661 ARG 1662 0.0198

ARG 1662 ASP 1663 0.0334

ASP 1663 CYS 1664 0.0133

CYS 1664 ASP 1665 0.0216

ASP 1665 SER 1666 0.0122

SER 1666 ASP 1667 0.0274

ASP 1667 GLU 1668 0.0305

GLU 1668 PHE 1669 0.0115

PHE 1669 TYR 1670 0.0131

TYR 1670 SER 1671 0.0277

SER 1671 PHE 1672 0.0051

PHE 1672 SER 1673 0.0315

SER 1673 VAL 1674 0.0042

VAL 1674 MET 1675 0.0345

MET 1675 MET 1676 0.0169

MET 1676 ALA 1677 0.1552

ALA 1677 THR 1678 0.0769

THR 1678 ALA 1679 0.1272

ALA 1679 SER 1680 0.1291

SER 1680 SER 1681 0.0552

SER 1681 THR 1682 0.1348

THR 1682 ILE 1683 0.1215

ILE 1683 ALA 1684 0.0956

ALA 1684 SER 1685 0.1290

SER 1685 SER 1686 0.0331

SER 1686 SER 1687 0.1333

SER 1687 MET 1688 0.1030

MET 1688 ALA 1689 0.1347

ALA 1689 PHE 1690 0.1316

PHE 1690 ALA 1691 0.1286

ALA 1691 ILE 1692 0.1233

ILE 1692 VAL 1693 0.3514

VAL 1693 TYR 1694 0.0764

TYR 1694 GLY 1695 0.0476

GLY 1695 GLU 1696 0.0694

GLU 1696 VAL 1697 0.0127

VAL 1697 PRO 1698 0.0602

PRO 1698 LEU 1699 0.0133

LEU 1699 PRO 1700 0.0335

PRO 1700 ASP 1701 0.0755

ASP 1701 GLN 1702 0.0053

GLN 1702 PHE 1703 0.0738

PHE 1703 LEU 1704 0.0398

LEU 1704 ASP 1705 0.0499

ASP 1705 ASP 1706 0.0375

ASP 1706 MET 1707 0.0431

MET 1707 LYS 1708 0.0690

LYS 1708 THR 1709 0.0015

THR 1709 ALA 1710 0.0802

ALA 1710 ILE 1711 0.0278

ILE 1711 SER 1712 0.0782

SER 1712 SER 1713 0.0143

SER 1713 SER 1714 0.0679

SER 1714 ALA 1715 0.0312

ALA 1715 VAL 1716 0.0785

VAL 1716 SER 1717 0.0473

SER 1717 ASP 1718 0.0814

ASP 1718 PRO 1719 0.0506

PRO 1719 VAL 1720 0.0293

VAL 1720 VAL 1721 0.0812

VAL 1721 GLY 1722 0.0183

GLY 1722 HIS 1723 0.0570

HIS 1723 LEU 1724 0.0579

LEU 1724 ASP 1725 0.1244

ASP 1725 SER 1726 0.0599

SER 1726 ILE 1727 0.0338

ILE 1727 ASP 1728 0.0663

ASP 1728 ALA 1729 0.0556

ALA 1729 THR 1730 0.0626

THR 1730 GLY 1731 0.0312

GLY 1731 LYS 1732 0.0391

LYS 1732 PHE 1733 0.0488

PHE 1733 CYS 1734 0.0628

CYS 1734 ILE 1735 0.0523

ILE 1735 PHE 1736 0.0369

PHE 1736 ILE 1737 0.0577

ILE 1737 GLU 1738 0.0403

GLU 1738 ASP 1739 0.0672

ASP 1739 PRO 1740 0.0636

PRO 1740 GLU 1741 0.1406

GLU 1741 THR 1742 0.0284

THR 1742 ASP 1743 0.0602

ASP 1743 ILE 1744 0.0405

ILE 1744 LEU 1745 0.0601

LEU 1745 SER 1746 0.0595

SER 1746 SER 1747 0.0187

SER 1747 PRO 1748 0.0611

PRO 1748 ASP 1749 0.0290

ASP 1749 GLU 1750 0.0446

GLU 1750 LYS 1751 0.0477

LYS 1751 SER 1752 0.0088

SER 1752 TYR 1753 0.0596

TYR 1753 ALA 1754 0.0549

ALA 1754 SER 1755 0.0229

SER 1755 ILE 1756 0.0408

ILE 1756 GLN 1757 0.0421

GLN 1757 LYS 1758 0.0575

LYS 1758 LEU 1759 0.0007

LEU 1759 VAL 1760 0.0585

VAL 1760 THR 1761 0.0317

THR 1761 ARG 1762 0.0502

ARG 1762 CYS 1763 0.0014

CYS 1763 LYS 1764 0.0421

LYS 1764 GLY 1765 0.0442

GLY 1765 LEU 1766 0.0576

LEU 1766 ILE 1767 0.0280

ILE 1767 TRP 1768 0.0482

TRP 1768 VAL 1769 0.0320

VAL 1769 SER 1770 0.0584

SER 1770 ARG 1771 0.0434

ARG 1771 GLY 1772 0.0586

GLY 1772 GLY 1773 0.0353

GLY 1773 ALA 1774 0.0321

ALA 1774 MET 1775 0.0168

MET 1775 HIS 1776 0.0390

HIS 1776 GLY 1777 0.0071

GLY 1777 THR 1778 0.0337

THR 1778 ARG 1779 0.0136

ARG 1779 PRO 1780 0.0170

PRO 1780 ASN 1781 0.0245

ASN 1781 SER 1782 0.0245

SER 1782 SER 1783 0.0372

SER 1783 LEU 1784 0.0033

LEU 1784 LYS 1785 0.0363

LYS 1785 THR 1786 0.0292

THR 1786 GLY 1787 0.0132

GLY 1787 LEU 1788 0.0280

LEU 1788 LEU 1789 0.0697

LEU 1789 ARG 1790 0.0475

ARG 1790 THR 1791 0.0007

THR 1791 LEU 1792 0.0475

LEU 1792 ARG 1793 0.0316

ARG 1793 LEU 1794 0.0205

LEU 1794 GLU 1795 0.0257

GLU 1795 TYR 1796 0.0360

TYR 1796 THR 1797 0.0337

THR 1797 GLU 1798 0.0452

GLU 1798 LYS 1799 0.0394

LYS 1799 ARG 1800 0.0077

ARG 1800 PHE 1801 0.0473

PHE 1801 ILE 1802 0.0093

ILE 1802 SER 1803 0.0454

SER 1803 LEU 1804 0.0088

LEU 1804 ASP 1805 -0.0041

ASP 1805 LEU 1806 0.0371

LEU 1806 ASP 1807 0.0779

ASP 1807 SER 1808 0.0762

SER 1808 ALA 1809 0.0325

ALA 1809 ARG 1810 0.0758

ARG 1810 PRO 1811 0.0977

PRO 1811 GLN 1812 0.0419

GLN 1812 TRP 1813 0.0803

TRP 1813 ASN 1814 0.0160

ASN 1814 HIS 1815 0.0685

HIS 1815 ASP 1816 0.0974

ASP 1816 SER 1817 0.0020

SER 1817 ILE 1818 0.0962

ILE 1818 THR 1819 0.0611

THR 1819 THR 1820 0.0563

THR 1820 ILE 1821 -0.0471

ILE 1821 ASN 1822 0.0443

ASN 1822 GLU 1823 0.0550

GLU 1823 VAL 1824 0.0138

VAL 1824 LEU 1825 0.0621

LEU 1825 CYS 1826 0.0212

CYS 1826 GLY 1827 0.0643

GLY 1827 ALA 1828 0.0088

ALA 1828 LEU 1829 0.0590

LEU 1829 ALA 1830 0.0215

ALA 1830 GLN 1831 0.0532

GLN 1831 ASN 1832 0.0661

ASN 1832 ALA 1833 0.0385

ALA 1833 ASP 1834 0.0563

ASP 1834 SER 1835 0.0656

SER 1835 SER 1836 0.0250

SER 1836 ILE 1837 0.1036

ILE 1837 LYS 1838 0.0651

LYS 1838 ASP 1839 0.0636

ASP 1839 SER 1840 0.0688

SER 1840 GLU 1841 0.0653

GLU 1841 PHE 1842 0.0025

PHE 1842 ALA 1843 0.0533

ALA 1843 GLU 1844 0.0019

GLU 1844 GLN 1845 0.0592

GLN 1845 ASP 1846 0.0006

ASP 1846 GLY 1847 0.0751

GLY 1847 GLN 1848 0.0533

GLN 1848 LEU 1849 0.0138

LEU 1849 PHE 1850 0.0362

PHE 1850 VAL 1851 0.0132

VAL 1851 PRO 1852 0.0278

PRO 1852 ARG 1853 -0.1352

ARG 1853 ILE 1854 0.0231

ILE 1854 SER 1855 0.0086

SER 1855 CYS 1856 0.0221

CYS 1856 ASP 1857 0.0188

ASP 1857 ILE 1858 0.0115

ILE 1858 ALA 1859 0.0175

ALA 1859 ARG 1860 0.0086

ARG 1860 ASN 1861 0.0218

ASN 1861 GLU 1862 0.0035

GLU 1862 ASP 1863 0.0233

ASP 1863 LEU 1864 0.0042

LEU 1864 SER 1865 0.0216

SER 1865 SER 1866 0.0054

SER 1866 ASP 1867 0.0205

ASP 1867 SER 1868 0.0234

SER 1868 ASN 1869 -0.2703

ASN 1869 SER 1870 0.0175

SER 1870 PRO 1871 0.0203

PRO 1871 ALA 1872 0.0012

ALA 1872 GLN 1873 0.0201

GLN 1873 MET 1874 0.0105

MET 1874 GLU 1875 0.0106

GLU 1875 PRO 1876 0.0024

PRO 1876 PHE 1877 0.0122

PHE 1877 HIS 1878 0.0114

HIS 1878 GLN 1879 0.0179

GLN 1879 PRO 1880 0.0139

PRO 1880 GLY 1881 0.0203

GLY 1881 LYS 1882 0.0117

LYS 1882 LEU 1883 0.0191

LEU 1883 LEU 1884 0.0155

LEU 1884 GLN 1885 -0.2603

GLN 1885 MET 1886 0.0157

MET 1886 GLY 1887 0.0176

GLY 1887 ILE 1888 0.0193

ILE 1888 LYS 1889 0.0297

LYS 1889 THR 1890 0.0034

THR 1890 PRO 1891 0.0135

PRO 1891 GLY 1892 0.0217

GLY 1892 LEU 1893 0.0124

LEU 1893 ILE 1894 0.0264

ILE 1894 ASP 1895 0.0144

ASP 1895 THR 1896 0.0273

THR 1896 LEU 1897 0.0285

LEU 1897 GLN 1898 0.0044

GLN 1898 PHE 1899 0.0173

PHE 1899 SER 1900 0.0262

SER 1900 LYS 1901 -0.1425

LYS 1901 THR 1902 0.0214

THR 1902 ASP 1903 0.0150

ASP 1903 ALA 1904 0.0125

ALA 1904 THR 1905 0.0216

THR 1905 ASP 1906 0.0037

ASP 1906 ASN 1907 0.0191

ASN 1907 LEU 1908 0.0206

LEU 1908 PRO 1909 0.0143

PRO 1909 ASN 1910 0.0183

ASN 1910 ASP 1911 0.0152

ASP 1911 TYR 1912 0.0216

TYR 1912 ILE 1913 0.0144

ILE 1913 GLU 1914 0.0206

GLU 1914 ILE 1915 0.0215

ILE 1915 GLU 1916 0.0197

GLU 1916 PRO 1917 0.0029

PRO 1917 LYS 1918 0.0418

LYS 1918 ALA 1919 0.0099

ALA 1919 PHE 1920 0.0038

PHE 1920 GLY 1921 0.0152

GLY 1921 LEU 1922 0.0215

LEU 1922 ASN 1923 0.0093

ASN 1923 PHE 1924 0.0061

PHE 1924 ARG 1925 0.0466

ARG 1925 ASP 1926 0.0270

ASP 1926 VAL 1927 0.0342

VAL 1927 MET 1928 0.0134

MET 1928 VAL 1929 0.0397

VAL 1929 ALA 1930 0.0414

ALA 1930 MET 1931 0.0071

MET 1931 GLY 1932 0.0401

GLY 1932 GLN 1933 0.1472

GLN 1933 LEU 1934 0.0438

LEU 1934 GLU 1935 0.0524

GLU 1935 GLU 1936 0.0026

GLU 1936 SER 1937 0.0333

SER 1937 ILE 1938 0.0214

ILE 1938 MET 1939 0.0421

MET 1939 GLY 1940 0.0210

GLY 1940 PHE 1941 0.0523

PHE 1941 GLU 1942 0.0218

GLU 1942 CYS 1943 0.0072

CYS 1943 ALA 1944 0.0153

ALA 1944 GLY 1945 0.0131

GLY 1945 VAL 1946 0.0144

VAL 1946 VAL 1947 0.0522

VAL 1947 ARG 1948 0.0420

ARG 1948 ARG 1949 -0.0575

ARG 1949 VAL 1950 0.0230

VAL 1950 GLY 1951 0.0201

GLY 1951 PRO 1952 0.0261

PRO 1952 SER 1953 0.0139

SER 1953 SER 1954 0.0283

SER 1954 ALA 1955 0.0025

ALA 1955 GLY 1956 0.0260

GLY 1956 HIS 1957 0.0229

HIS 1957 ASN 1958 0.0115

ASN 1958 ILE 1959 0.0287

ILE 1959 LYS 1960 0.0076

LYS 1960 VAL 1961 0.0257

VAL 1961 GLY 1962 0.0260

GLY 1962 ASP 1963 0.0166

ASP 1963 ARG 1964 0.0236

ARG 1964 VAL 1965 -0.0208

VAL 1965 CYS 1966 0.0040

CYS 1966 ALA 1967 0.0130

ALA 1967 LEU 1968 0.0008

LEU 1968 LEU 1969 0.0264

LEU 1969 GLY 1970 0.0152

GLY 1970 GLY 1971 0.0265

GLY 1971 GLN 1972 0.0124

GLN 1972 TRP 1973 0.0198

TRP 1973 THR 1974 0.0084

THR 1974 ASN 1975 0.0007

ASN 1975 THR 1976 0.0263

THR 1976 VAL 1977 0.0140

VAL 1977 ARG 1978 0.0255

ARG 1978 VAL 1979 0.0194

VAL 1979 HIS 1980 0.0257

HIS 1980 TRP 1981 0.0017

TRP 1981 HIS 1982 0.0118

HIS 1982 SER 1983 0.0279

SER 1983 VAL 1984 0.0029

VAL 1984 ALA 1985 0.0233

ALA 1985 PRO 1986 0.0031

PRO 1986 ILE 1987 0.0273

ILE 1987 PRO 1988 0.0183

PRO 1988 GLN 1989 0.0050

GLN 1989 ALA 1990 0.0280

ALA 1990 MET 1991 0.0075

MET 1991 ASP 1992 0.0281

ASP 1992 TRP 1993 0.0218

TRP 1993 GLU 1994 0.0157

GLU 1994 THR 1995 0.0254

THR 1995 ALA 1996 0.0280

ALA 1996 ALA 1997 0.0130

ALA 1997 SER 1998 0.0227

SER 1998 ILE 1999 0.0278

ILE 1999 PRO 2000 0.0260

PRO 2000 ILE 2001 0.0114

ILE 2001 VAL 2002 0.0326

VAL 2002 PHE 2003 0.0331

PHE 2003 VAL 2004 0.0262

VAL 2004 THR 2005 0.0143

THR 2005 ALA 2006 0.0331

ALA 2006 TYR 2007 0.0327

TYR 2007 ILE 2008 0.0176

ILE 2008 SER 2009 0.0208

SER 2009 LEU 2010 0.0329

LEU 2010 VAL 2011 0.0295

VAL 2011 LYS 2012 0.0283

LYS 2012 ILE 2013 0.0345

ILE 2013 ALA 2014 0.0208

ALA 2014 ARG 2015 0.0261

ARG 2015 MET 2016 0.0319

MET 2016 GLN 2017 0.0346

GLN 2017 ALA 2018 0.0347

ALA 2018 GLY 2019 0.0075

GLY 2019 GLU 2020 0.0302

GLU 2020 THR 2021 0.0297

THR 2021 VAL 2022 0.0303

VAL 2022 LEU 2023 0.0313

LEU 2023 ILE 2024 0.0166

ILE 2024 HIS 2025 0.0330

HIS 2025 ALA 2026 0.0241

ALA 2026 ALA 2027 0.0292

ALA 2027 SER 2028 0.0247

SER 2028 GLY 2029 0.0236

GLY 2029 GLY 2030 0.0238

GLY 2030 VAL 2031 0.0221

VAL 2031 GLY 2032 0.0256

GLY 2032 GLN 2033 0.0186

GLN 2033 ALA 2034 0.0362

ALA 2034 ALA 2035 0.0038

ALA 2035 ILE 2036 0.0395

ILE 2036 ILE 2037 0.0115

ILE 2037 LEU 2038 0.0356

LEU 2038 ALA 2039 0.0077

ALA 2039 LYS 2040 0.0328

LYS 2040 HIS 2041 0.0269

HIS 2041 VAL 2042 0.0133

VAL 2042 GLY 2043 0.0323

GLY 2043 ALA 2044 0.0196

ALA 2044 GLU 2045 -0.0285

GLU 2045 ILE 2046 0.0478

ILE 2046 PHE 2047 0.0319

PHE 2047 ALA 2048 0.0407

ALA 2048 THR 2049 0.0466

THR 2049 VAL 2050 0.0370

VAL 2050 GLY 2051 0.0483

GLY 2051 THR 2052 0.0470

THR 2052 ASP 2053 0.0489

ASP 2053 GLU 2054 0.0001

GLU 2054 LYS 2055 0.0489

LYS 2055 ARG 2056 0.0268

ARG 2056 ASP 2057 0.0335

ASP 2057 LEU 2058 0.0201

LEU 2058 LEU 2059 0.0371

LEU 2059 ILE 2060 0.0445

ILE 2060 LYS 2061 0.0287

LYS 2061 GLU 2062 0.0274

GLU 2062 TYR 2063 0.0431

TYR 2063 LYS 2064 0.0311

LYS 2064 ILE 2065 0.0237

ILE 2065 PRO 2066 0.0144

PRO 2066 ASP 2067 0.0422

ASP 2067 ASP 2068 0.0180

ASP 2068 HIS 2069 0.0377

HIS 2069 ILE 2070 0.0494

ILE 2070 PHE 2071 0.0356

PHE 2071 SER 2072 0.0531

SER 2072 SER 2073 0.0453

SER 2073 ARG 2074 0.0403

ARG 2074 ASN 2075 0.0090

ASN 2075 ALA 2076 0.0434

ALA 2076 LEU 2077 0.1379

LEU 2077 PHE 2078 0.0134

PHE 2078 ALA 2079 0.0322

ALA 2079 LYS 2080 0.0045

LYS 2080 SER 2081 0.0306

SER 2081 ILE 2082 0.0131

ILE 2082 ARG 2083 0.0221

ARG 2083 GLN 2084 0.0178

GLN 2084 ARG 2085 0.0153

ARG 2085 THR 2086 0.0277

THR 2086 ASN 2087 0.0064

ASN 2087 GLY 2088 0.0325

GLY 2088 LYS 2089 0.0074

LYS 2089 GLY 2090 0.0238

GLY 2090 VAL 2091 0.0016

VAL 2091 ASP 2092 0.0165

ASP 2092 VAL 2093 -0.0506

VAL 2093 VAL 2094 0.0335

VAL 2094 LEU 2095 0.0154

LEU 2095 ASN 2096 0.0312

ASN 2096 CYS 2097 0.0296

CYS 2097 LEU 2098 0.0091

LEU 2098 ALA 2099 0.0334

ALA 2099 GLY 2100 0.0149

GLY 2100 GLY 2101 0.0058

GLY 2101 LEU 2102 0.0311

LEU 2102 LEU 2103 0.0177

LEU 2103 GLN 2104 0.0165

GLN 2104 GLU 2105 0.0220

GLU 2105 SER 2106 0.0137

SER 2106 PHE 2107 0.0329

PHE 2107 ASP 2108 0.0020

ASP 2108 CYS 2109 -0.0080

CYS 2109 LEU 2110 0.0063

LEU 2110 ALA 2111 0.0086

ALA 2111 ASP 2112 0.0085

ASP 2112 PHE 2113 0.0029

PHE 2113 GLY 2114 0.0075

GLY 2114 ARG 2115 0.0040

ARG 2115 PHE 2116 0.0088

PHE 2116 ILE 2117 0.0023

ILE 2117 GLU 2118 0.0089

GLU 2118 ILE 2119 0.0030

ILE 2119 GLY 2120 0.0068

GLY 2120 LYS 2121 0.0089

LYS 2121 ARG 2122 0.0043

ARG 2122 ASP 2123 0.0029

ASP 2123 ILE 2124 0.0065

ILE 2124 GLU 2125 -0.0605

GLU 2125 LEU 2126 0.0038

LEU 2126 ASN 2127 0.0058

ASN 2127 HIS 2128 0.0013

HIS 2128 CYS 2129 0.0026

CYS 2129 LEU 2130 0.0059

LEU 2130 ASN 2131 0.0006

ASN 2131 MET 2132 0.0071

MET 2132 GLY 2133 0.0010

GLY 2133 MET 2134 0.0063

MET 2134 PHE 2135 0.0058

PHE 2135 ALA 2136 0.0011

ALA 2136 ARG 2137 0.0073

ARG 2137 SER 2138 0.0025

SER 2138 ALA 2139 0.0053

ALA 2139 THR 2140 0.0001

THR 2140 PHE 2141 0.1248

PHE 2141 THR 2142 0.0056

THR 2142 ALA 2143 0.0085

ALA 2143 VAL 2144 0.0030

VAL 2144 ASP 2145 0.0088

ASP 2145 LEU 2146 0.0047

LEU 2146 ILE 2147 0.0152

ILE 2147 ALA 2148 0.0048

ALA 2148 ILE 2149 0.0162

ILE 2149 GLY 2150 0.0016

GLY 2150 ARG 2151 0.0153

ARG 2151 ASP 2152 0.0050

ASP 2152 ARG 2153 0.0162

ARG 2153 SER 2154 0.0007

SER 2154 TYR 2155 0.0157

TYR 2155 MET 2156 0.0145

MET 2156 PHE 2157 0.1052

PHE 2157 ALA 2158 0.0203

ALA 2158 GLU 2159 0.0294

GLU 2159 ALA 2160 0.0337

ALA 2160 LEU 2161 0.0120

LEU 2161 PRO 2162 0.0182

PRO 2162 LYS 2163 0.0265

LYS 2163 ILE 2164 0.0343

ILE 2164 MET 2165 0.0011

MET 2165 THR 2166 0.0335

THR 2166 LEU 2167 0.0249

LEU 2167 LEU 2168 0.0251

LEU 2168 GLN 2169 0.0090

GLN 2169 GLU 2170 0.0319

GLU 2170 LYS 2171 0.0321

LYS 2171 ALA 2172 0.0064

ALA 2172 ILE 2173 -0.0106

ILE 2173 ARG 2174 0.0256

ARG 2174 PRO 2175 0.0378

PRO 2175 VAL 2176 0.0308

VAL 2176 THR 2177 0.0299

THR 2177 PRO 2178 0.0301

PRO 2178 ILE 2179 0.0345

ILE 2179 SER 2180 0.0368

SER 2180 ILE 2181 0.0198

ILE 2181 TYR 2182 0.0376

TYR 2182 LYS 2183 0.0253

LYS 2183 ILE 2184 0.0304

ILE 2184 GLY 2185 0.0325

GLY 2185 ASP 2186 0.0284

ASP 2186 ILE 2187 0.0097

ILE 2187 GLU 2188 0.0291

GLU 2188 THR 2189 0.0536

THR 2189 ALA 2190 0.0373

ALA 2190 PHE 2191 0.0115

PHE 2191 ARG 2192 0.0394

ARG 2192 LEU 2193 0.0393

LEU 2193 MET 2194 0.0239

MET 2194 GLN 2195 0.0224

GLN 2195 ALA 2196 0.0405

ALA 2196 GLY 2197 0.0390

GLY 2197 LYS 2198 0.0178

LYS 2198 HIS 2199 0.0302

HIS 2199 MET 2200 0.0407

MET 2200 GLY 2201 0.0393

GLY 2201 LYS 2202 0.0368

LYS 2202 ILE 2203 0.0322

ILE 2203 VAL 2204 0.0217

VAL 2204 ILE 2205 -0.0366

ILE 2205 THR 2206 0.0166

THR 2206 ALA 2207 0.0195

ALA 2207 PRO 2208 0.0164

PRO 2208 GLU 2209 0.0222

GLU 2209 ASP 2210 0.0174

ASP 2210 ALA 2211 0.0150

ALA 2211 MET 2212 0.0013

MET 2212 VAL 2213 0.0120

VAL 2213 PRO 2214 0.0002

PRO 2214 VAL 2215 0.0209

VAL 2215 ILE 2216 0.0033

ILE 2216 THR 2217 0.0222

THR 2217 ARG 2218 0.0148

ARG 2218 PRO 2219 0.0155

PRO 2219 PRO 2220 0.0211

PRO 2220 LYS 2221 0.6912

LYS 2221 LEU 2222 0.0095

LEU 2222 GLN 2223 0.0098

GLN 2223 LEU 2224 0.0104

LEU 2224 ARG 2225 0.0113

ARG 2225 PRO 2226 0.0047

PRO 2226 ASP 2227 0.0085

ASP 2227 ALA 2228 0.0043

ALA 2228 SER 2229 0.0108

SER 2229 TYR 2230 0.0099

TYR 2230 LEU 2231 0.0075

LEU 2231 ILE 2232 0.0115

ILE 2232 VAL 2233 0.0064

VAL 2233 GLY 2234 0.0096

GLY 2234 GLY 2235 0.0024

GLY 2235 LEU 2236 0.0090

LEU 2236 GLY 2237 -0.1669

GLY 2237 GLY 2238 0.0137

GLY 2238 ILE 2239 0.0021

ILE 2239 GLY 2240 0.0141

GLY 2240 ARG 2241 0.0055

ARG 2241 SER 2242 0.0130

SER 2242 LEU 2243 0.0026

LEU 2243 CYS 2244 0.0119

CYS 2244 LYS 2245 0.0102

LYS 2245 ASN 2246 0.0056

ASN 2246 PHE 2247 0.0095

PHE 2247 VAL 2248 0.0085

VAL 2248 GLU 2249 0.0144

GLU 2249 ASN 2250 0.0001

ASN 2250 GLY 2251 0.0144

GLY 2251 ALA 2252 0.0145

ALA 2252 ARG 2253 0.1033

ARG 2253 SER 2254 0.0145

SER 2254 LEU 2255 0.0174

LEU 2255 VAL 2256 0.0151

VAL 2256 LEU 2257 0.0153

LEU 2257 LEU 2258 0.0129

LEU 2258 SER 2259 0.0137

SER 2259 ARG 2260 0.0174

ARG 2260 ASN 2261 0.0007

ASN 2261 ALA 2262 0.0164

ALA 2262 ASN 2263 0.0071

ASN 2263 VAL 2264 0.0120

VAL 2264 SER 2265 0.0154

SER 2265 GLN 2266 0.0032

GLN 2266 GLN 2267 0.0169

GLN 2267 SER 2268 0.0118

SER 2268 GLY 2269 0.2705

GLY 2269 GLU 2270 0.0480

GLU 2270 PHE 2271 0.0103

PHE 2271 LEU 2272 0.0382

LEU 2272 ASP 2273 0.0381

ASP 2273 GLU 2274 0.0464

GLU 2274 LEU 2275 0.0034

LEU 2275 ARG 2276 0.0489

ARG 2276 SER 2277 0.0399

SER 2277 THR 2278 0.0135

THR 2278 GLY 2279 0.0388

GLY 2279 CYS 2280 0.0408

CYS 2280 ILE 2281 0.0485

ILE 2281 VAL 2282 0.0417

VAL 2282 GLY 2283 0.0470

GLY 2283 VAL 2284 0.0344

VAL 2284 VAL 2285 -0.2277

VAL 2285 ASP 2286 0.0143

ASP 2286 CYS 2287 0.0098

CYS 2287 ASP 2288 0.0148

ASP 2288 ILE 2289 0.0190

ILE 2289 SER 2290 0.0084

SER 2290 SER 2291 0.0153

SER 2291 LYS 2292 0.0167

LYS 2292 THR 2293 0.0197

THR 2293 GLN 2294 0.0012

GLN 2294 VAL 2295 0.0183

VAL 2295 GLU 2296 0.0135

GLU 2296 ALA 2297 0.0173

ALA 2297 THR 2298 0.0026

THR 2298 MET 2299 0.0194

MET 2299 LEU 2300 0.0173

LEU 2300 ARG 2301 -0.0996

ARG 2301 LEU 2302 0.0079

LEU 2302 LYS 2303 0.0116

LYS 2303 LYS 2304 0.0108

LYS 2304 ASP 2305 0.0049

ASP 2305 MET 2306 0.0106

MET 2306 LEU 2307 0.0119

LEU 2307 PRO 2308 0.0055

PRO 2308 ILE 2309 0.0116

ILE 2309 ARG 2310 0.0119

ARG 2310 GLY 2311 0.0123

GLY 2311 ILE 2312 0.0103

ILE 2312 VAL 2313 0.0119

VAL 2313 HIS 2314 0.0063

HIS 2314 ALA 2315 0.0100

ALA 2315 GLY 2316 0.0072

GLY 2316 MET 2317 0.2222

MET 2317 VAL 2318 0.0141

VAL 2318 LEU 2319 0.0372

LEU 2319 GLN 2320 0.0234

GLN 2320 ASP 2321 0.0328

ASP 2321 SER 2322 0.0348

SER 2322 VAL 2323 0.0289

VAL 2323 PHE 2324 0.0356

PHE 2324 GLU 2325 0.0246

GLU 2325 ARG 2326 0.0153

ARG 2326 MET 2327 0.0344

MET 2327 SER 2328 0.0213

SER 2328 LEU 2329 0.0340

LEU 2329 ASP 2330 0.0302

ASP 2330 ASP 2331 0.0286

ASP 2331 TYR 2332 0.0108

TYR 2332 ASN 2333 -0.2691

ASN 2333 THR 2334 0.0135

THR 2334 ALA 2335 0.0020

ALA 2335 ILE 2336 0.0141

ILE 2336 ARG 2337 0.0131

ARG 2337 PRO 2338 0.0056

PRO 2338 LYS 2339 0.0077

LYS 2339 VAL 2340 0.0111

VAL 2340 GLN 2341 0.0093

GLN 2341 GLY 2342 0.0105

GLY 2342 SER 2343 0.0035

SER 2343 TRP 2344 0.0118

TRP 2344 ASN 2345 0.0120

ASN 2345 LEU 2346 0.0029

LEU 2346 HIS 2347 0.0121

HIS 2347 SER 2348 0.0077

SER 2348 GLY 2349 0.0154

GLY 2349 LEU 2350 0.0011

LEU 2350 SER 2351 0.0159

SER 2351 ASP 2352 0.0158

ASP 2352 CYS 2353 0.0052

CYS 2353 ASP 2354 0.0027

ASP 2354 LEU 2355 0.0143

LEU 2355 ASP 2356 0.0009

ASP 2356 PHE 2357 0.0146

PHE 2357 PHE 2358 0.0058

PHE 2358 ILE 2359 0.0154

ILE 2359 MET 2360 0.0092

MET 2360 LEU 2361 0.0151

LEU 2361 SER 2362 0.0131

SER 2362 SER 2363 0.0157

SER 2363 LEU 2364 0.0121

LEU 2364 ALA 2365 0.2104

ALA 2365 GLY 2366 0.0203

GLY 2366 VAL 2367 0.0044

VAL 2367 SER 2368 0.0204

SER 2368 GLY 2369 0.0040

GLY 2369 SER 2370 0.0089

SER 2370 ALA 2371 0.0102

ALA 2371 SER 2372 0.0049

SER 2372 GLN 2373 0.0172

GLN 2373 ALA 2374 0.0207

ALA 2374 ASN 2375 0.0190

ASN 2375 TYR 2376 0.0160

TYR 2376 THR 2377 0.0066

THR 2377 ALA 2378 0.0213

ALA 2378 GLY 2379 0.0213

GLY 2379 GLY 2380 0.0065

GLY 2380 ALA 2381 -0.0165

ALA 2381 TYR 2382 0.0105

TYR 2382 GLN 2383 0.0063

GLN 2383 ASP 2384 0.0059

ASP 2384 ALA 2385 0.0104

ALA 2385 LEU 2386 0.0120

LEU 2386 ALA 2387 0.0008

ALA 2387 LYS 2388 0.0112

LYS 2388 TYR 2389 0.0074

TYR 2389 ARG 2390 0.0103

ARG 2390 ARG 2391 0.0016

ARG 2391 ALA 2392 0.0116

ALA 2392 GLN 2393 0.0108

GLN 2393 GLY 2394 0.0028

GLY 2394 LEU 2395 0.0101

LEU 2395 SER 2396 0.0104

SER 2396 ALA 2397 0.0665

ALA 2397 VAL 2398 0.0028

VAL 2398 SER 2399 0.0015

SER 2399 ILE 2400 0.0024

ILE 2400 ASP 2401 0.0016

ASP 2401 LEU 2402 0.0023

LEU 2402 GLY 2403 0.0027

GLY 2403 MET 2404 0.0027

MET 2404 VAL 2405 0.0014

VAL 2405 GLN 2406 0.0023

GLN 2406 SER 2407 0.0020

SER 2407 VAL 2408 0.0021

VAL 2408 GLY 2409 0.0005

GLY 2409 TYR 2410 0.0004

TYR 2410 VAL 2411 0.0026

VAL 2411 ALA 2412 0.0012

ALA 2412 GLU 2413 -0.0995

GLU 2413 THR 2414 0.0004

THR 2414 LYS 2415 0.0072

LYS 2415 GLY 2416 0.0063

GLY 2416 VAL 2417 0.0080

VAL 2417 ALA 2418 0.0047

ALA 2418 GLU 2419 0.0050

GLU 2419 ARG 2420 0.0054

ARG 2420 LEU 2421 0.0047

LEU 2421 VAL 2422 0.0080

VAL 2422 ARG 2423 0.0009

ARG 2423 MET 2424 0.0089

MET 2424 GLY 2425 0.0035

GLY 2425 TYR 2426 0.0042

TYR 2426 SER 2427 0.0021

SER 2427 PRO 2428 0.0066

PRO 2428 ILE 2429 0.1935

ILE 2429 SER 2430 0.0134

SER 2430 GLU 2431 0.0099

GLU 2431 MET 2432 0.0107

MET 2432 GLU 2433 0.0172

GLU 2433 VAL 2434 0.0197

VAL 2434 LEU 2435 0.0018

LEU 2435 LYS 2436 0.0187

LYS 2436 ILE 2437 0.0159

ILE 2437 VAL 2438 0.0146

VAL 2438 GLU 2439 0.0057

GLU 2439 HIS 2440 0.0193

HIS 2440 ALA 2441 0.0188

ALA 2441 ILE 2442 0.0040

ILE 2442 THR 2443 0.0144

THR 2443 ASN 2444 0.0156

ASN 2444 PRO 2445 -0.3580

PRO 2445 PRO 2446 0.0090

PRO 2446 PRO 2447 0.0090

PRO 2447 GLU 2448 0.0070

GLU 2448 ALA 2449 0.0022

ALA 2449 SER 2450 0.0071

SER 2450 SER 2451 0.0059

SER 2451 ALA 2452 0.0040

ALA 2452 GLN 2453 0.0090

GLN 2453 ILE 2454 0.0042

ILE 2454 ILE 2455 0.0088

ILE 2455 THR 2456 0.0074

THR 2456 GLY 2457 0.0084

GLY 2457 ILE 2458 0.0078

ILE 2458 SER 2459 0.0027

SER 2459 THR 2460 0.0037

THR 2460 LYS 2461 -0.0428

LYS 2461 PRO 2462 0.0162

PRO 2462 GLY 2463 0.0194

GLY 2463 ARG 2464 0.0171

ARG 2464 HIS 2465 0.0036

HIS 2465 TRP 2466 0.0205

TRP 2466 THR 2467 0.0204

THR 2467 GLU 2468 0.0152

GLU 2468 SER 2469 0.0089

SER 2469 SER 2470 0.0091

SER 2470 TRP 2471 0.0164

TRP 2471 LEU 2472 0.0064

LEU 2472 GLN 2473 0.0201

GLN 2473 ASP 2474 0.0061

ASP 2474 ALA 2475 0.0201

ALA 2475 ARG 2476 0.0192

ARG 2476 PHE 2477 -0.0189

PHE 2477 ALA 2478 0.0230

ALA 2478 THR 2479 0.0234

THR 2479 LEU 2480 0.0168

LEU 2480 ARG 2481 0.0214

ARG 2481 GLU 2482 0.0224

GLU 2482 ARG 2483 0.0221

ARG 2483 ALA 2484 0.0195

ALA 2484 ARG 2485 0.0226

ARG 2485 ASP 2486 0.0235

ASP 2486 VAL 2487 0.0190

VAL 2487 LYS 2488 0.0214

LYS 2488 GLU 2489 0.0241

GLU 2489 LEU 2490 0.0231

LEU 2490 SER 2491 0.0143

SER 2491 ASN 2492 0.0223

ASN 2492 SER 2493 0.1638

SER 2493 GLN 2494 0.0973

GLN 2494 ASN 989 -0.1727

ASN 989 LYS 990 0.1201

LYS 990 ALA 991 0.1343

ALA 991 HIS 992 0.1138

HIS 992 ARG 993 0.0768

ARG 993 GLN 994 0.1337

GLN 994 ARG 995 0.1337

ARG 995 VAL 996 0.0788

VAL 996 HIS 997 0.1280

HIS 997 PRO 998 0.1235

PRO 998 PRO 999 0.1151

PRO 999 HIS 1000 0.1240

HIS 1000 ASP 1001 0.1222

ASP 1001 LEU 1002 0.0901

LEU 1002 LEU 1003 0.0637

LEU 1003 GLY 1004 0.1347

GLY 1004 SER 1005 0.0025

SER 1005 LEU 1006 0.0473

LEU 1006 ILE 1007 0.0070

ILE 1007 VAL 1008 0.0606

VAL 1008 GLY 1009 0.0185

GLY 1009 ARG 1010 0.0692

ARG 1010 ASP 1011 0.0701

ASP 1011 LEU 1012 0.0079

LEU 1012 ARG 1013 0.0661

ARG 1013 GLU 1014 0.0695

GLU 1014 PRO 1015 0.0444

PRO 1015 THR 1016 0.0697

THR 1016 TRP 1017 0.0342

TRP 1017 ARG 1018 0.0689

ARG 1018 HIS 1019 0.0303

HIS 1019 PHE 1020 0.0699

PHE 1020 ILE 1021 0.1920

ILE 1021 ARG 1022 0.0550

ARG 1022 VAL 1023 0.0359

VAL 1023 GLN 1024 0.0554

GLN 1024 ASP 1025 0.0786

ASP 1025 ILE 1026 0.0788

ILE 1026 PRO 1027 0.0530

PRO 1027 TRP 1028 0.0785

TRP 1028 ILE 1029 0.0101

ILE 1029 ARG 1030 0.0698

ARG 1030 ASP 1031 0.0642

ASP 1031 HIS 1032 0.0222

HIS 1032 VAL 1033 0.0633

VAL 1033 VAL 1034 0.0416

VAL 1034 GLN 1035 0.0706

GLN 1035 SER 1036 0.0635

SER 1036 ALA 1037 0.1247

ALA 1037 LEU 1038 0.0574

LEU 1038 VAL 1039 0.0570

VAL 1039 TYR 1040 0.0659

TYR 1040 PRO 1041 0.0556

PRO 1041 GLY 1042 0.0420

GLY 1042 ALA 1043 0.0355

ALA 1043 GLY 1044 0.0644

GLY 1044 PHE 1045 0.0091

PHE 1045 ILE 1046 0.0583

ILE 1046 CYS 1047 0.0365

CYS 1047 MET 1048 0.0320

MET 1048 ALA 1049 0.0502

ALA 1049 MET 1050 0.0242

MET 1050 GLU 1051 0.0641

GLU 1051 ALA 1052 0.0047

ALA 1052 MET 1053 0.0754

MET 1053 VAL 1054 0.0269

VAL 1054 GLN 1055 0.0703

GLN 1055 LEU 1056 0.0404

LEU 1056 HIS 1057 0.0528

HIS 1057 GLU 1058 0.0709

GLU 1058 LEU 1059 0.0218

LEU 1059 ARG 1060 0.0812

ARG 1060 ASP 1061 0.0365

ASP 1061 SER 1062 0.0669

SER 1062 GLN 1063 0.0748

GLN 1063 SER 1064 0.0371

SER 1064 ARG 1065 0.0852

ARG 1065 LYS 1066 0.0482

LYS 1066 VAL 1067 0.0757

VAL 1067 ALA 1068 0.0803

ALA 1068 GLY 1069 -0.0075

GLY 1069 TYR 1070 0.0315

TYR 1070 ARG 1071 0.0379

ARG 1071 LEU 1072 0.0446

LEU 1072 ALA 1073 0.0334

ALA 1073 GLU 1074 0.0411

GLU 1074 VAL 1075 0.0441

VAL 1075 ASP 1076 0.0504

ASP 1076 ILE 1077 0.0485

ILE 1077 LEU 1078 0.0213

LEU 1078 ARG 1079 0.0509

ARG 1079 ALA 1080 0.0142

ALA 1080 MET 1081 0.0590

MET 1081 LEU 1082 0.0530

LEU 1082 ILE 1083 0.0412

ILE 1083 PRO 1084 0.0595

PRO 1084 ASP 1085 0.0959

ASP 1085 THR 1086 0.0412

THR 1086 SER 1087 0.0563

SER 1087 GLU 1088 0.0180

GLU 1088 GLY 1089 0.0517

GLY 1089 LEU 1090 0.0373

LEU 1090 GLU 1091 0.0406

GLU 1091 ALA 1092 0.0549

ALA 1092 HIS 1093 0.0468

HIS 1093 ILE 1094 0.0538

ILE 1094 SER 1095 0.0306

SER 1095 LEU 1096 0.0553

LEU 1096 ARG 1097 0.0235

ARG 1097 PRO 1098 0.0562

PRO 1098 CYS 1099 0.0547

CYS 1099 SER 1100 0.0160

SER 1100 THR 1101 0.1029

THR 1101 LYS 1102 0.0280

LYS 1102 LEU 1103 0.0070

LEU 1103 LEU 1104 0.0331

LEU 1104 LEU 1105 0.0095

LEU 1105 THR 1106 0.0331

THR 1106 ASN 1107 0.0193

ASN 1107 GLU 1108 0.0331

GLU 1108 TRP 1109 0.0268

TRP 1109 TYR 1110 0.0316

TYR 1110 ASP 1111 0.0329

ASP 1111 PHE 1112 0.0112

PHE 1112 CYS 1113 0.0320

CYS 1113 VAL 1114 0.0085

VAL 1114 SER 1115 0.0330

SER 1115 SER 1116 0.0248

SER 1116 VAL 1117 0.1397

VAL 1117 GLY 1118 0.0479

GLY 1118 ASP 1119 0.0452

ASP 1119 ASP 1120 0.0062

ASP 1120 ASP 1121 0.0477

ASP 1121 LYS 1122 0.0481

LYS 1122 PHE 1123 0.0373

PHE 1123 VAL 1124 0.0286

VAL 1124 ASP 1125 0.0448

ASP 1125 HIS 1126 0.0026

HIS 1126 CYS 1127 0.0474

CYS 1127 ARG 1128 0.0330

ARG 1128 GLY 1129 0.0463

GLY 1129 ARG 1130 0.0478

ARG 1130 ILE 1131 0.0333

ILE 1131 THR 1132 0.0479

THR 1132 ILE 1133 -0.0338

ILE 1133 GLU 1134 0.0607

GLU 1134 PHE 1135 0.0432

PHE 1135 ASP 1136 0.0387

ASP 1136 THR 1137 0.0505

THR 1137 SER 1138 0.0406

SER 1138 GLY 1139 0.0538

GLY 1139 SER 1140 0.0579

SER 1140 ALA 1141 0.0413

ALA 1141 ASP 1142 0.0657

ASP 1142 THR 1143 0.0194

THR 1143 PRO 1144 0.0420

PRO 1144 ARG 1145 0.0638

ARG 1145 THR 1146 0.0664

THR 1146 SER 1147 0.0174

SER 1147 LEU 1148 0.0649

LEU 1148 ARG 1149 -0.1314

ARG 1149 GLU 1150 0.0170

GLU 1150 ARG 1151 0.0060

ARG 1151 SER 1152 0.0145

SER 1152 ARG 1153 0.0132

ARG 1153 SER 1154 0.0121

SER 1154 THR 1155 0.0157

THR 1155 GLY 1156 0.0158

GLY 1156 LEU 1157 0.0174

LEU 1157 MET 1158 0.0168

MET 1158 ARG 1159 0.0167

ARG 1159 SER 1160 0.0183

SER 1160 VAL 1161 0.0065

VAL 1161 ASP 1162 0.0185

ASP 1162 PRO 1163 0.0102

PRO 1163 SER 1164 0.0169

SER 1164 ASN 1165 -0.2982

ASN 1165 LEU 1166 0.0105

LEU 1166 TYR 1167 0.0538

TYR 1167 SER 1168 0.0485

SER 1168 PHE 1169 0.0226

PHE 1169 LEU 1170 0.0302

LEU 1170 ARG 1171 0.0469

ARG 1171 ALA 1172 0.0533

ALA 1172 GLN 1173 0.0056

GLN 1173 GLY 1174 0.0534

GLY 1174 ILE 1175 0.0532

ILE 1175 TYR 1176 0.0209

TYR 1176 HIS 1177 0.0483

HIS 1177 GLY 1178 0.0262

GLY 1178 PRO 1179 0.0221

PRO 1179 ILE 1180 0.0408

ILE 1180 PHE 1181 0.0838

PHE 1181 GLN 1182 0.0335

GLN 1182 ASN 1183 0.0524

ASN 1183 LEU 1184 0.0537

LEU 1184 LYS 1185 0.0154

LYS 1185 THR 1186 0.0512

THR 1186 ILE 1187 0.0216

ILE 1187 SER 1188 0.0527

SER 1188 SER 1189 0.0157

SER 1189 ARG 1190 0.0379

ARG 1190 LYS 1191 0.0117

LYS 1191 ASP 1192 0.0386

ASP 1192 HIS 1193 0.0316

HIS 1193 SER 1194 0.0185

SER 1194 GLU 1195 0.0292

GLU 1195 SER 1196 0.0473

SER 1196 SER 1197 -0.0109

SER 1197 PHE 1198 0.0836

PHE 1198 VAL 1199 0.0688

VAL 1199 VAL 1200 0.0715

VAL 1200 ALA 1201 0.0821

ALA 1201 ASN 1202 0.0682

ASN 1202 THR 1203 0.0287

THR 1203 ALA 1204 0.0749

ALA 1204 SER 1205 0.0404

SER 1205 VAL 1206 0.0504

VAL 1206 MET 1207 0.0618

MET 1207 PRO 1208 0.0805

PRO 1208 ASN 1209 0.0381

ASN 1209 GLY 1210 0.0833

GLY 1210 PHE 1211 0.0354

PHE 1211 GLN 1212 0.0436

GLN 1212 SER 1213 0.0323

SER 1213 PRO 1214 0.0714

PRO 1214 HIS 1215 0.0570

HIS 1215 VAL 1216 0.0715

VAL 1216 ILE 1217 0.0695

ILE 1217 HIS 1218 0.0710

HIS 1218 PRO 1219 0.0526

PRO 1219 THR 1220 0.0227

THR 1220 THR 1221 0.0680

THR 1221 LEU 1222 0.0149

LEU 1222 ASP 1223 0.0728

ASP 1223 SER 1224 0.0155

SER 1224 ILE 1225 0.0610

ILE 1225 PHE 1226 0.0323

PHE 1226 GLN 1227 0.0415

GLN 1227 GLY 1228 0.0622

GLY 1228 ALA 1229 0.0371

ALA 1229 TYR 1230 0.0465

TYR 1230 THR 1231 0.0238

THR 1231 ALA 1232 0.0291

ALA 1232 LEU 1233 0.0428

LEU 1233 PRO 1234 0.0457

PRO 1234 GLY 1235 0.0104

GLY 1235 ALA 1236 0.0495

ALA 1236 GLY 1237 0.0309

GLY 1237 LEU 1238 0.0351

LEU 1238 ASP 1239 0.0254

ASP 1239 GLN 1240 0.0242

GLN 1240 ASN 1241 0.0356

ASN 1241 THR 1242 0.0454

THR 1242 ALA 1243 0.0468

ALA 1243 MET 1244 0.0413

MET 1244 ILE 1245 0.0950

ILE 1245 PRO 1246 0.0556

PRO 1246 ARG 1247 0.0003

ARG 1247 SER 1248 0.0571

SER 1248 ILE 1249 0.0504

ILE 1249 GLN 1250 0.0446

GLN 1250 GLU 1251 0.0402

GLU 1251 LEU 1252 0.0183

LEU 1252 TYR 1253 0.0450

TYR 1253 LEU 1254 0.0243

LEU 1254 SER 1255 0.0421

SER 1255 SER 1256 0.0535

SER 1256 ALA 1257 0.0146

ALA 1257 LEU 1258 0.0586

LEU 1258 THR 1259 0.0298

THR 1259 SER 1260 0.0595

SER 1260 ASP 1261 0.1044

ASP 1261 VAL 1262 0.0665

VAL 1262 GLY 1263 0.0699

GLY 1263 GLN 1264 0.0585

GLN 1264 CYS 1265 0.0654

CYS 1265 LEU 1266 0.0062

LEU 1266 VAL 1267 0.0607

VAL 1267 SER 1268 0.0059

SER 1268 ASP 1269 0.0509

ASP 1269 THR 1270 0.0293

THR 1270 SER 1271 0.0279

SER 1271 LEU 1272 0.0426

LEU 1272 ILE 1273 0.0097

ILE 1273 ARG 1274 0.0600

ARG 1274 TYR 1275 0.0709

TYR 1275 ASP 1276 0.0460

ASP 1276 GLY 1277 0.0782

GLY 1277 GLN 1278 0.0471

GLN 1278 SER 1279 0.0549

SER 1279 PHE 1280 0.0430

PHE 1280 THR 1281 0.0552

THR 1281 VAL 1282 0.0243

VAL 1282 ASN 1283 0.0522

ASN 1283 VAL 1284 0.0111

VAL 1284 ASP 1285 0.0408

ASP 1285 VAL 1286 0.0168

VAL 1286 SER 1287 0.0260

SER 1287 SER 1288 0.0089

SER 1288 LYS 1289 0.0291

LYS 1289 ALA 1290 0.0401

ALA 1290 ASP 1291 0.0271

ASP 1291 SER 1292 0.0546

SER 1292 GLU 1293 0.0911

GLU 1293 HIS 1294 0.0483

HIS 1294 THR 1295 0.0284

THR 1295 PRO 1296 0.0358

PRO 1296 VAL 1297 0.0562

VAL 1297 LEU 1298 0.0287

LEU 1298 GLU 1299 0.0253

GLU 1299 ILE 1300 0.0340

ILE 1300 LYS 1301 0.0213

LYS 1301 GLY 1302 0.0409

GLY 1302 LEU 1303 0.0422

LEU 1303 ARG 1304 0.0393

ARG 1304 ASN 1305 0.0480

ASN 1305 GLN 1306 0.0364

GLN 1306 SER 1307 0.0556

SER 1307 VAL 1308 0.0566

VAL 1308 GLY 1309 0.2197

GLY 1309 GLN 1310 0.1159

GLN 1310 MET 1311 0.0963

MET 1311 ALA 1312 0.0711

ALA 1312 PRO 1313 0.1114

PRO 1313 GLN 1314 0.0901

GLN 1314 PRO 1315 0.0853

PRO 1315 GLY 1316 0.1062

GLY 1316 ASP 1317 0.1139

ASP 1317 SER 1318 0.0132

SER 1318 SER 1319 0.1156

SER 1319 ASN 1320 0.1132

ASN 1320 ASN 1321 0.0151

ASN 1321 ASP 1322 0.1173

ASP 1322 LEU 1323 0.0972

LEU 1323 CYS 1324 0.0729

CYS 1324 PHE 1325 0.3254

PHE 1325 LYS 1326 0.0053

LYS 1326 LEU 1327 0.0174

LEU 1327 ASP 1328 0.0369

ASP 1328 TRP 1329 0.0107

TRP 1329 ALA 1330 0.0390

ALA 1330 PRO 1331 0.0224

PRO 1331 ASP 1332 0.0389

ASP 1332 ILE 1333 0.0382

ILE 1333 SER 1334 0.0346

SER 1334 SER 1335 0.0064

SER 1335 VAL 1336 0.0396

VAL 1336 LYS 1337 0.0168

LYS 1337 GLN 1338 0.0381

GLN 1338 GLU 1339 0.0209

GLU 1339 ARG 1340 0.0325

ARG 1340 LEU 1341 0.3768

LEU 1341 LYS 1342 0.0107

LYS 1342 GLU 1343 0.0381

GLU 1343 LYS 1344 0.0097

LYS 1344 PHE 1345 0.0394

PHE 1345 GLY 1346 0.0030

GLY 1346 PHE 1347 0.0393

PHE 1347 PRO 1348 0.0227

PRO 1348 LEU 1349 0.0221

LEU 1349 ASP 1350 0.0394

ASP 1350 PRO 1351 0.0158

PRO 1351 THR 1352 0.0384

THR 1352 GLU 1353 0.0424

GLU 1353 ALA 1354 0.0075

ALA 1354 ASP 1355 0.0378

ASP 1355 ILE 1356 0.0332

ILE 1356 ILE 1357 0.0091

ILE 1357 MET 1358 0.0061

MET 1358 GLY 1359 0.1663

GLY 1359 LEU 1360 0.0979

LEU 1360 ARG 1361 0.1058

ARG 1361 GLN 1362 0.1010

GLN 1362 ALA 1363 0.1018

ALA 1363 CYS 1364 0.1600

CYS 1364 ILE 1365 0.0199

ILE 1365 HIS 1366 0.1689

HIS 1366 PHE 1367 0.0660

PHE 1367 ILE 1368 0.1592

ILE 1368 HIS 1369 0.0214

HIS 1369 ARG 1370 0.1578

ARG 1370 SER 1371 0.0996

SER 1371 LEU 1372 0.1081

LEU 1372 GLN 1373 0.1220

GLN 1373 SER 1374 0.1126

SER 1374 LEU 1375 0.1508

LEU 1375 THR 1376 0.1747

THR 1376 ALA 1377 0.1881

ALA 1377 PRO 1378 0.0648

PRO 1378 ASP 1379 0.1598

ASP 1379 ARG 1380 0.1825

ARG 1380 ASP 1381 0.1629

ASP 1381 GLN 1382 0.0602

GLN 1382 LEU 1383 0.1867

LEU 1383 ASP 1384 0.0600

ASP 1384 TRP 1385 0.1869

TRP 1385 HIS 1386 0.1864

HIS 1386 GLN 1387 0.1206

GLN 1387 LYS 1388 0.1167

LYS 1388 ARG 1389 0.0954

ARG 1389 PHE 1390 0.1666

PHE 1390 TYR 1391 0.0685

TYR 1391 ASP 1392 0.1498

ASP 1392 TRP 1393 0.1656

TRP 1393 MET 1394 0.1392

MET 1394 VAL 1395 0.0707

VAL 1395 LEU 1396 0.1699

LEU 1396 GLN 1397 0.1698

GLN 1397 ILE 1398 0.0684

ILE 1398 GLN 1399 0.1364

GLN 1399 LEU 1400 0.1613

LEU 1400 ALA 1401 0.1550

ALA 1401 GLU 1402 0.0484

GLU 1402 GLU 1403 0.1686

GLU 1403 ASP 1404 0.1674

ASP 1404 ARG 1405 -0.0171

ARG 1405 LEU 1406 0.0987

LEU 1406 ALA 1407 0.1875

ALA 1407 PRO 1408 0.0402

PRO 1408 ASN 1409 0.1817

ASN 1409 SER 1410 0.1075

SER 1410 SER 1411 0.1288

SER 1411 ALA 1412 0.2154

ALA 1412 TRP 1413 0.0226

TRP 1413 LEU 1414 0.2083

LEU 1414 GLN 1415 0.1370

GLN 1415 CYS 1416 0.1502

CYS 1416 SER 1417 0.2177

SER 1417 SER 1418 0.0864

SER 1418 SER 1419 0.2165

SER 1419 ASP 1420 0.2183

ASP 1420 GLU 1421 0.1529

GLU 1421 GLN 1422 0.0991

GLN 1422 LYS 1423 0.1985

LYS 1423 LEU 1424 0.1987

LEU 1424 LEU 1425 0.0863

LEU 1425 GLU 1426 0.1553

GLU 1426 ASN 1427 0.1927

ASN 1427 VAL 1428 0.1898

VAL 1428 ARG 1429 0.0656

ARG 1429 ALA 1430 0.1888

ALA 1430 SER 1431 0.1874

SER 1431 SER 1432 0.1297

SER 1432 VAL 1433 0.1156

VAL 1433 ASN 1434 0.1060

ASN 1434 GLY 1435 0.1454

GLY 1435 GLN 1436 0.0901

GLN 1436 MET 1437 0.0462

MET 1437 VAL 1438 0.0184

VAL 1438 VAL 1439 0.1811

VAL 1439 HIS 1440 0.0604

HIS 1440 VAL 1441 0.1833

VAL 1441 GLY 1442 0.0012

GLY 1442 LYS 1443 0.1866

LYS 1443 SER 1444 0.1288

SER 1444 MET 1445 0.1525

MET 1445 LEU 1446 0.1541

LEU 1446 ALA 1447 0.0552

ALA 1447 ILE 1448 0.1537

ILE 1448 LEU 1449 0.1035

LEU 1449 ARG 1450 0.1832

ARG 1450 HIS 1451 0.0067

HIS 1451 GLU 1452 0.1827

GLU 1452 ILE 1453 0.3535

ILE 1453 ALA 1454 0.1614

ALA 1454 PRO 1455 0.1248

PRO 1455 LEU 1456 0.0960

LEU 1456 GLU 1457 0.1317

GLU 1457 LEU 1458 0.0710

LEU 1458 MET 1459 0.1786

MET 1459 LEU 1460 0.0181

LEU 1460 GLN 1461 0.1815

GLN 1461 ASP 1462 0.1810

ASP 1462 LYS 1463 0.1796

LYS 1463 LEU 1464 0.0019

LEU 1464 LEU 1465 0.1814

LEU 1465 TYR 1466 0.1301

TYR 1466 ARG 1467 0.1098

ARG 1467 TYR 1468 0.0908

TYR 1468 TYR 1469 0.2711

TYR 1469 THR 1470 0.0270

THR 1470 ASP 1471 0.0240

ASP 1471 ALA 1472 0.0039

ALA 1472 ILE 1473 0.0196

ILE 1473 LYS 1474 0.0347

LYS 1474 TRP 1475 0.0080

TRP 1475 ASP 1476 0.0232

ASP 1476 ARG 1477 0.0237

ARG 1477 SER 1478 0.0348

SER 1478 TYR 1479 0.0008

TYR 1479 GLN 1480 0.0345

GLN 1480 GLN 1481 0.0260

GLN 1481 ILE 1482 0.0216

ILE 1482 ASP 1483 0.0128

ASP 1483 GLN 1484 0.0320

GLN 1484 LEU 1485 0.3615

LEU 1485 VAL 1486 0.0058

VAL 1486 LYS 1487 0.0048

LYS 1487 LEU 1488 0.0081

LEU 1488 HIS 1489 0.0001

HIS 1489 ALA 1490 0.0081

ALA 1490 HIS 1491 0.0055

HIS 1491 LYS 1492 0.0048

LYS 1492 CYS 1493 0.0024

CYS 1493 PRO 1494 0.0075

PRO 1494 THR 1495 0.0003

THR 1495 ALA 1496 0.0080

ALA 1496 LYS 1497 0.0039

LYS 1497 ILE 1498 0.0065

ILE 1498 ILE 1499 0.0072

ILE 1499 GLU 1500 0.0060

GLU 1500 ILE 1501 0.1004

ILE 1501 GLY 1502 0.0062

GLY 1502 ALA 1503 0.0008

ALA 1503 GLY 1504 0.0063

GLY 1504 THR 1505 0.0025

THR 1505 GLY 1506 0.0057

GLY 1506 GLY 1507 0.0061

GLY 1507 CYS 1508 0.0058

CYS 1508 THR 1509 0.0039

THR 1509 ARG 1510 0.0026

ARG 1510 ALA 1511 0.0055

ALA 1511 VAL 1512 0.0061

VAL 1512 LEU 1513 0.0015

LEU 1513 ASP 1514 0.0048

ASP 1514 ALA 1515 0.0044

ALA 1515 LEU 1516 0.0060

LEU 1516 SER 1517 -0.2049

SER 1517 ASN 1518 0.0017

ASN 1518 GLN 1519 0.0003

GLN 1519 GLY 1520 0.0017

GLY 1520 ILE 1521 0.0001

ILE 1521 ALA 1522 0.0010

ALA 1522 ARG 1523 0.0007

ARG 1523 CYS 1524 0.0014

CYS 1524 ALA 1525 0.0012

ALA 1525 GLN 1526 0.0016

GLN 1526 TYR 1527 0.0010

TYR 1527 ASP 1528 0.0017

ASP 1528 PHE 1529 0.0004

PHE 1529 THR 1530 0.0016

THR 1530 ASP 1531 0.0015

ASP 1531 VAL 1532 0.0013

VAL 1532 SER 1533 -0.0631

SER 1533 SER 1534 0.0035

SER 1534 GLY 1535 0.0071

GLY 1535 PHE 1536 0.0085

PHE 1536 PHE 1537 0.0088

PHE 1537 GLU 1538 0.0005

GLU 1538 ALA 1539 0.0087

ALA 1539 ALA 1540 0.0041

ALA 1540 GLN 1541 0.0064

GLN 1541 GLN 1542 0.0045

GLN 1542 LYS 1543 0.0045

LYS 1543 PHE 1544 0.0073

PHE 1544 ALA 1545 0.0035

ALA 1545 ALA 1546 0.0083

ALA 1546 PHE 1547 0.0035

PHE 1547 ASP 1548 0.0072

ASP 1548 ASP 1549 -0.1124

ASP 1549 VAL 1550 0.0031

VAL 1550 ILE 1551 0.0050

ILE 1551 ARG 1552 0.0024

ARG 1552 PHE 1553 0.0048

PHE 1553 GLN 1554 0.0048

GLN 1554 LYS 1555 0.0051

LYS 1555 LEU 1556 0.0034

LEU 1556 ASP 1557 0.0052

ASP 1557 ILE 1558 0.0021

ILE 1558 GLU 1559 0.0049

GLU 1559 LYS 1560 0.0009

LYS 1560 ASP 1561 0.0051

ASP 1561 ILE 1562 0.0052

ILE 1562 GLU 1563 0.0025

GLU 1563 MET 1564 0.0028

MET 1564 GLN 1565 -0.0168

GLN 1565 GLY 1566 0.0099

GLY 1566 PHE 1567 0.0024

PHE 1567 GLU 1568 0.0101

GLU 1568 CYS 1569 0.0025

CYS 1569 GLY 1570 0.0059

GLY 1570 SER 1571 0.0075

SER 1571 TYR 1572 0.0078

TYR 1572 ASP 1573 0.0045

ASP 1573 LEU 1574 0.0101

LEU 1574 VAL 1575 0.0107

VAL 1575 ILE 1576 0.0106

ILE 1576 ALA 1577 0.0106

ALA 1577 SER 1578 0.0100

SER 1578 GLN 1579 0.0104

GLN 1579 VAL 1580 0.0063

VAL 1580 LEU 1581 0.3012

LEU 1581 HIS 1582 0.0239

HIS 1582 ALA 1583 0.0157

ALA 1583 THR 1584 0.0211

THR 1584 GLY 1585 0.0315

GLY 1585 LYS 1586 0.0332

LYS 1586 MET 1587 0.0223

MET 1587 GLU 1588 0.0303

GLU 1588 HIS 1589 0.0050

HIS 1589 THR 1590 0.0307

THR 1590 MET 1591 0.0253

MET 1591 ALA 1592 0.0148

ALA 1592 ASN 1593 0.0244

ASN 1593 VAL 1594 0.0157

VAL 1594 ARG 1595 0.0339

ARG 1595 LYS 1596 0.0019

LYS 1596 LEU 1597 0.0027

LEU 1597 LEU 1598 0.0082

LEU 1598 LYS 1599 0.0145

LYS 1599 PRO 1600 0.0077

PRO 1600 GLY 1601 0.0056

GLY 1601 GLY 1602 0.0127

GLY 1602 LYS 1603 0.0089

LYS 1603 LEU 1604 0.0147

LEU 1604 LEU 1605 0.0119

LEU 1605 LEU 1606 0.0138

LEU 1606 VAL 1607 0.0125

VAL 1607 GLU 1608 0.0137

GLU 1608 THR 1609 0.0093

THR 1609 THR 1610 0.0076

THR 1610 ARG 1611 0.0092

ARG 1611 ASP 1612 0.0128

ASP 1612 GLU 1613 -0.1066

GLU 1613 MET 1614 0.1036

MET 1614 ASP 1615 0.0766

ASP 1615 LEU 1616 0.0463

LEU 1616 GLN 1617 0.1051

GLN 1617 LEU 1618 0.1128

LEU 1618 VAL 1619 0.0259

VAL 1619 PHE 1620 0.0836

PHE 1620 GLY 1621 0.0759

GLY 1621 LEU 1622 0.1124

LEU 1622 LEU 1623 0.0229

LEU 1623 PRO 1624 0.1165

PRO 1624 GLY 1625 0.0962

GLY 1625 TRP 1626 0.0336

TRP 1626 TRP 1627 0.1052

TRP 1627 LEU 1628 0.0523

LEU 1628 SER 1629 -0.1628

SER 1629 SER 1630 0.0907

SER 1630 GLU 1631 0.0561

GLU 1631 GLU 1632 0.0107

GLU 1632 GLU 1633 0.0786

GLU 1633 ARG 1634 0.0599

ARG 1634 GLN 1635 0.0896

GLN 1635 MET 1636 0.0499

MET 1636 SER 1637 0.0732

SER 1637 PRO 1638 0.0141

PRO 1638 SER 1639 0.0781

SER 1639 LEU 1640 0.0870

LEU 1640 SER 1641 0.0408

SER 1641 THR 1642 0.0859

THR 1642 ASN 1643 0.0805

ASN 1643 SER 1644 0.0575

SER 1644 TRP 1645 0.0468

TRP 1645 GLU 1646 0.0327

GLU 1646 LYS 1647 0.0311

LYS 1647 VAL 1648 0.0096

VAL 1648 LEU 1649 0.0342

LEU 1649 LYS 1650 0.0344

LYS 1650 LYS 1651 0.0225

LYS 1651 THR 1652 0.0172

THR 1652 GLY 1653 0.0348

GLY 1653 PHE 1654 0.0174

PHE 1654 ASP 1655 0.0148

ASP 1655 GLY 1656 0.0201

GLY 1656 LEU 1657 0.0265

LEU 1657 ASP 1658 0.0350

ASP 1658 ILE 1659 0.0263

ILE 1659 GLU 1660 0.0278

GLU 1660 LEU 1661 0.1267

LEU 1661 ARG 1662 0.0167

ARG 1662 ASP 1663 0.0291

ASP 1663 CYS 1664 0.0118

CYS 1664 ASP 1665 0.0190

ASP 1665 SER 1666 0.0102

SER 1666 ASP 1667 0.0236

ASP 1667 GLU 1668 0.0264

GLU 1668 PHE 1669 0.0103

PHE 1669 TYR 1670 0.0113

TYR 1670 SER 1671 0.0242

SER 1671 PHE 1672 0.0043

PHE 1672 SER 1673 0.0269

SER 1673 VAL 1674 0.0033

VAL 1674 MET 1675 0.0296

MET 1675 MET 1676 0.0146

MET 1676 ALA 1677 -0.0109

ALA 1677 THR 1678 0.0679

THR 1678 ALA 1679 0.1139

ALA 1679 SER 1680 0.1153

SER 1680 SER 1681 0.0479

SER 1681 THR 1682 0.1199

THR 1682 ILE 1683 0.1070

ILE 1683 ALA 1684 0.0854

ALA 1684 SER 1685 0.1154

SER 1685 SER 1686 0.0276

SER 1686 SER 1687 0.1185

SER 1687 MET 1688 0.0904

MET 1688 ALA 1689 0.1199

ALA 1689 PHE 1690 0.1175

PHE 1690 ALA 1691 0.1137

ALA 1691 ILE 1692 0.1108

ILE 1692 VAL 1693 -0.2958

VAL 1693 TYR 1694 0.0690

TYR 1694 GLY 1695 0.0419

GLY 1695 GLU 1696 0.0613

GLU 1696 VAL 1697 0.0124

VAL 1697 PRO 1698 0.0538

PRO 1698 LEU 1699 0.0109

LEU 1699 PRO 1700 0.0314

PRO 1700 ASP 1701 0.0678

ASP 1701 GLN 1702 0.0042

GLN 1702 PHE 1703 0.0666

PHE 1703 LEU 1704 0.0362

LEU 1704 ASP 1705 0.0446

ASP 1705 ASP 1706 0.0325

ASP 1706 MET 1707 0.0398

MET 1707 LYS 1708 0.0622

LYS 1708 THR 1709 0.0040

THR 1709 ALA 1710 0.0718

ALA 1710 ILE 1711 0.0263

ILE 1711 SER 1712 0.0702

SER 1712 SER 1713 0.0115

SER 1713 SER 1714 0.0615

SER 1714 ALA 1715 0.0281

ALA 1715 VAL 1716 0.0704

VAL 1716 SER 1717 0.0406

SER 1717 ASP 1718 0.0730

ASP 1718 PRO 1719 0.0451

PRO 1719 VAL 1720 0.0242

VAL 1720 VAL 1721 0.0726

VAL 1721 GLY 1722 0.0153

GLY 1722 HIS 1723 0.0504

HIS 1723 LEU 1724 0.0529

LEU 1724 ASP 1725 -0.0854

ASP 1725 SER 1726 0.0541

SER 1726 ILE 1727 0.0291

ILE 1727 ASP 1728 0.0598

ASP 1728 ALA 1729 0.0491

ALA 1729 THR 1730 0.0570

THR 1730 GLY 1731 0.0268

GLY 1731 LYS 1732 0.0360

LYS 1732 PHE 1733 0.0437

PHE 1733 CYS 1734 0.0559

CYS 1734 ILE 1735 0.0477

ILE 1735 PHE 1736 0.0321

PHE 1736 ILE 1737 0.0529

ILE 1737 GLU 1738 0.0355

GLU 1738 ASP 1739 0.0608

ASP 1739 PRO 1740 0.0572

PRO 1740 GLU 1741 -0.0687

GLU 1741 THR 1742 0.0266

THR 1742 ASP 1743 0.0548

ASP 1743 ILE 1744 0.0369

ILE 1744 LEU 1745 0.0547

LEU 1745 SER 1746 0.0537

SER 1746 SER 1747 0.0159

SER 1747 PRO 1748 0.0550

PRO 1748 ASP 1749 0.0252

ASP 1749 GLU 1750 0.0410

GLU 1750 LYS 1751 0.0430

LYS 1751 SER 1752 0.0078

SER 1752 TYR 1753 0.0540

TYR 1753 ALA 1754 0.0496

ALA 1754 SER 1755 0.0213

SER 1755 ILE 1756 0.0361

ILE 1756 GLN 1757 0.0157

GLN 1757 LYS 1758 0.0515

LYS 1758 LEU 1759 0.0007

LEU 1759 VAL 1760 0.0524

VAL 1760 THR 1761 0.0294

THR 1761 ARG 1762 0.0453

ARG 1762 CYS 1763 0.0012

CYS 1763 LYS 1764 0.0366

LYS 1764 GLY 1765 0.0399

GLY 1765 LEU 1766 0.0519

LEU 1766 ILE 1767 0.0259

ILE 1767 TRP 1768 0.0425

TRP 1768 VAL 1769 0.0297

VAL 1769 SER 1770 0.0520

SER 1770 ARG 1771 0.0395

ARG 1771 GLY 1772 0.0527

GLY 1772 GLY 1773 0.1027

GLY 1773 ALA 1774 0.0281

ALA 1774 MET 1775 0.0147

MET 1775 HIS 1776 0.0349

HIS 1776 GLY 1777 0.0060

GLY 1777 THR 1778 0.0303

THR 1778 ARG 1779 0.0118

ARG 1779 PRO 1780 0.0157

PRO 1780 ASN 1781 0.0213

ASN 1781 SER 1782 0.0214

SER 1782 SER 1783 0.0336

SER 1783 LEU 1784 0.0028

LEU 1784 LYS 1785 0.0326

LYS 1785 THR 1786 0.0257

THR 1786 GLY 1787 0.0122

GLY 1787 LEU 1788 0.0251

LEU 1788 LEU 1789 -0.0186

LEU 1789 ARG 1790 0.0424

ARG 1790 THR 1791 0.0008

THR 1791 LEU 1792 0.0422

LEU 1792 ARG 1793 0.0273

ARG 1793 LEU 1794 0.0190

LEU 1794 GLU 1795 0.0224

GLU 1795 TYR 1796 0.0321

TYR 1796 THR 1797 0.0291

THR 1797 GLU 1798 0.0406

GLU 1798 LYS 1799 0.0358

LYS 1799 ARG 1800 0.0073

ARG 1800 PHE 1801 0.0423

PHE 1801 ILE 1802 0.0086

ILE 1802 SER 1803 0.0408

SER 1803 LEU 1804 0.0085

LEU 1804 ASP 1805 0.1285

ASP 1805 LEU 1806 0.0348

LEU 1806 ASP 1807 0.0701

ASP 1807 SER 1808 0.0673

SER 1808 ALA 1809 0.0298

ALA 1809 ARG 1810 0.0681

ARG 1810 PRO 1811 0.0875

PRO 1811 GLN 1812 0.0376

GLN 1812 TRP 1813 0.0722

TRP 1813 ASN 1814 0.0129

ASN 1814 HIS 1815 0.0603

HIS 1815 ASP 1816 0.0876

ASP 1816 SER 1817 0.0019

SER 1817 ILE 1818 0.0865

ILE 1818 THR 1819 0.0529

THR 1819 THR 1820 0.0516

THR 1820 ILE 1821 0.0616

ILE 1821 ASN 1822 0.0393

ASN 1822 GLU 1823 0.0483

GLU 1823 VAL 1824 0.0130

VAL 1824 LEU 1825 0.0555

LEU 1825 CYS 1826 0.0179

CYS 1826 GLY 1827 0.0578

GLY 1827 ALA 1828 0.0081

ALA 1828 LEU 1829 0.0527

LEU 1829 ALA 1830 0.0179

ALA 1830 GLN 1831 0.0485

GLN 1831 ASN 1832 0.0594

ASN 1832 ALA 1833 0.0356

ALA 1833 ASP 1834 0.0499

ASP 1834 SER 1835 0.0592

SER 1835 SER 1836 0.0230

SER 1836 ILE 1837 0.1853

ILE 1837 LYS 1838 0.0579

LYS 1838 ASP 1839 0.0565

ASP 1839 SER 1840 0.0597

SER 1840 GLU 1841 0.0576

GLU 1841 PHE 1842 0.0026

PHE 1842 ALA 1843 0.0475

ALA 1843 GLU 1844 0.0018

GLU 1844 GLN 1845 0.0521

GLN 1845 ASP 1846 0.0007

ASP 1846 GLY 1847 0.0659

GLY 1847 GLN 1848 0.0476

GLN 1848 LEU 1849 0.0120

LEU 1849 PHE 1850 0.0319

PHE 1850 VAL 1851 0.0125

VAL 1851 PRO 1852 0.0242

PRO 1852 ARG 1853 0.1251

ARG 1853 ILE 1854 0.0184

ILE 1854 SER 1855 0.0067

SER 1855 CYS 1856 0.0176

CYS 1856 ASP 1857 0.0145

ASP 1857 ILE 1858 0.0094

ILE 1858 ALA 1859 0.0132

ALA 1859 ARG 1860 0.0076

ARG 1860 ASN 1861 0.0172

ASN 1861 GLU 1862 0.0027

GLU 1862 ASP 1863 0.0187

ASP 1863 LEU 1864 0.0035

LEU 1864 SER 1865 0.0174

SER 1865 SER 1866 0.0038

SER 1866 ASP 1867 0.0165

ASP 1867 SER 1868 0.0185

SER 1868 ASN 1869 0.2515

ASN 1869 SER 1870 0.0162

SER 1870 PRO 1871 0.0182

PRO 1871 ALA 1872 0.0022

ALA 1872 GLN 1873 0.0180

GLN 1873 MET 1874 0.0108

MET 1874 GLU 1875 0.0096

GLU 1875 PRO 1876 0.0036

PRO 1876 PHE 1877 0.0092

PHE 1877 HIS 1878 0.0108

HIS 1878 GLN 1879 0.0158

GLN 1879 PRO 1880 0.0123

PRO 1880 GLY 1881 0.0180

GLY 1881 LYS 1882 0.0113

LYS 1882 LEU 1883 0.0163

LEU 1883 LEU 1884 0.0135

LEU 1884 GLN 1885 0.2085

GLN 1885 MET 1886 0.0097

MET 1886 GLY 1887 0.0138

GLY 1887 ILE 1888 0.0127

ILE 1888 LYS 1889 0.0230

LYS 1889 THR 1890 0.0016

THR 1890 PRO 1891 0.0115

PRO 1891 GLY 1892 0.0144

GLY 1892 LEU 1893 0.0115

LEU 1893 ILE 1894 0.0203

ILE 1894 ASP 1895 0.0127

ASP 1895 THR 1896 0.0196

THR 1896 LEU 1897 0.0212

LEU 1897 GLN 1898 0.0019

GLN 1898 PHE 1899 0.0113

PHE 1899 SER 1900 0.0188

SER 1900 LYS 1901 0.1588

LYS 1901 THR 1902 0.0151

THR 1902 ASP 1903 0.0097

ASP 1903 ALA 1904 0.0070

ALA 1904 THR 1905 0.0150

THR 1905 ASP 1906 0.0012

ASP 1906 ASN 1907 0.0143

ASN 1907 LEU 1908 0.0148

LEU 1908 PRO 1909 0.0118

PRO 1909 ASN 1910 0.0109

ASN 1910 ASP 1911 0.0112

ASP 1911 TYR 1912 0.0150

TYR 1912 ILE 1913 0.0107

ILE 1913 GLU 1914 0.0148

GLU 1914 ILE 1915 0.0150

ILE 1915 GLU 1916 0.0146

GLU 1916 PRO 1917 -0.0050

PRO 1917 LYS 1918 0.0337

LYS 1918 ALA 1919 0.0068

ALA 1919 PHE 1920 0.0042

PHE 1920 GLY 1921 0.0125

GLY 1921 LEU 1922 0.0142

LEU 1922 ASN 1923 0.0095

ASN 1923 PHE 1924 0.0029

PHE 1924 ARG 1925 0.0368

ARG 1925 ASP 1926 0.0234

ASP 1926 VAL 1927 0.0240

VAL 1927 MET 1928 0.0126

MET 1928 VAL 1929 0.0303

VAL 1929 ALA 1930 0.0343

ALA 1930 MET 1931 0.0040

MET 1931 GLY 1932 0.0327

GLY 1932 GLN 1933 -0.1061

GLN 1933 LEU 1934 0.0323

LEU 1934 GLU 1935 0.0427

GLU 1935 GLU 1936 0.0006

GLU 1936 SER 1937 0.0307

SER 1937 ILE 1938 0.0152

ILE 1938 MET 1939 0.0360

MET 1939 GLY 1940 0.0162

GLY 1940 PHE 1941 0.0425

PHE 1941 GLU 1942 0.0178

GLU 1942 CYS 1943 0.0088

CYS 1943 ALA 1944 0.0119

ALA 1944 GLY 1945 0.0111

GLY 1945 VAL 1946 0.0090

VAL 1946 VAL 1947 0.0421

VAL 1947 ARG 1948 0.0354

ARG 1948 ARG 1949 0.0798

ARG 1949 VAL 1950 0.0174

VAL 1950 GLY 1951 0.0147

GLY 1951 PRO 1952 0.0165

PRO 1952 SER 1953 0.0111

SER 1953 SER 1954 0.0197

SER 1954 ALA 1955 0.0008

ALA 1955 GLY 1956 0.0187

GLY 1956 HIS 1957 0.0153

HIS 1957 ASN 1958 0.0084

ASN 1958 ILE 1959 0.0194

ILE 1959 LYS 1960 0.0070

LYS 1960 VAL 1961 0.0186

VAL 1961 GLY 1962 0.0183

GLY 1962 ASP 1963 0.0129

ASP 1963 ARG 1964 0.0156

ARG 1964 VAL 1965 0.0275

VAL 1965 CYS 1966 0.0017

CYS 1966 ALA 1967 0.0092

ALA 1967 LEU 1968 0.0005

LEU 1968 LEU 1969 0.0181

LEU 1969 GLY 1970 0.0105

GLY 1970 GLY 1971 0.0179

GLY 1971 GLN 1972 0.0106

GLN 1972 TRP 1973 0.0151

TRP 1973 THR 1974 0.0058

THR 1974 ASN 1975 0.0012

ASN 1975 THR 1976 0.0181

THR 1976 VAL 1977 0.0116

VAL 1977 ARG 1978 0.0183

ARG 1978 VAL 1979 0.0150

VAL 1979 HIS 1980 0.0182

HIS 1980 TRP 1981 0.0379

TRP 1981 HIS 1982 0.0093

HIS 1982 SER 1983 0.0191

SER 1983 VAL 1984 0.0025

VAL 1984 ALA 1985 0.0155

ALA 1985 PRO 1986 0.0027

PRO 1986 ILE 1987 0.0193

ILE 1987 PRO 1988 0.0121

PRO 1988 GLN 1989 0.0049

GLN 1989 ALA 1990 0.0191

ALA 1990 MET 1991 0.0038

MET 1991 ASP 1992 0.0196

ASP 1992 TRP 1993 0.0146

TRP 1993 GLU 1994 0.0095

GLU 1994 THR 1995 0.0185

THR 1995 ALA 1996 0.0194

ALA 1996 ALA 1997 0.0105

ALA 1997 SER 1998 0.0167

SER 1998 ILE 1999 0.0213

ILE 1999 PRO 2000 0.0190

PRO 2000 ILE 2001 0.0071

ILE 2001 VAL 2002 0.0240

VAL 2002 PHE 2003 0.0242

PHE 2003 VAL 2004 0.0194

VAL 2004 THR 2005 0.0092

THR 2005 ALA 2006 0.0244

ALA 2006 TYR 2007 0.0238

TYR 2007 ILE 2008 0.0124

ILE 2008 SER 2009 0.0148

SER 2009 LEU 2010 0.0239

LEU 2010 VAL 2011 0.0209

VAL 2011 LYS 2012 0.0208

LYS 2012 ILE 2013 0.0192

ILE 2013 ALA 2014 0.0152

ALA 2014 ARG 2015 0.0200

ARG 2015 MET 2016 0.0238

MET 2016 GLN 2017 0.0270

GLN 2017 ALA 2018 0.0271

ALA 2018 GLY 2019 0.0044

GLY 2019 GLU 2020 0.0239

GLU 2020 THR 2021 0.0223

THR 2021 VAL 2022 0.0240

VAL 2022 LEU 2023 0.0241

LEU 2023 ILE 2024 0.0137

ILE 2024 HIS 2025 0.0256

HIS 2025 ALA 2026 0.0201

ALA 2026 ALA 2027 0.0230

ALA 2027 SER 2028 0.0204

SER 2028 GLY 2029 0.0326

GLY 2029 GLY 2030 0.0163

GLY 2030 VAL 2031 0.0178

VAL 2031 GLY 2032 0.0181

GLY 2032 GLN 2033 0.0141

GLN 2033 ALA 2034 0.0259

ALA 2034 ALA 2035 0.0037

ALA 2035 ILE 2036 0.0294

ILE 2036 ILE 2037 0.0079

ILE 2037 LEU 2038 0.0274

LEU 2038 ALA 2039 0.0051

ALA 2039 LYS 2040 0.0249

LYS 2040 HIS 2041 0.0184

HIS 2041 VAL 2042 0.0113

VAL 2042 GLY 2043 0.0233

GLY 2043 ALA 2044 0.0138

ALA 2044 GLU 2045 0.0453

GLU 2045 ILE 2046 0.0371

ILE 2046 PHE 2047 0.0225

PHE 2047 ALA 2048 0.0322

ALA 2048 THR 2049 0.0348

THR 2049 VAL 2050 0.0304

VAL 2050 GLY 2051 0.0363

GLY 2051 THR 2052 0.0367

THR 2052 ASP 2053 0.0374

ASP 2053 GLU 2054 0.0005

GLU 2054 LYS 2055 0.0371

LYS 2055 ARG 2056 0.0208

ARG 2056 ASP 2057 0.0269

ASP 2057 LEU 2058 0.0127

LEU 2058 LEU 2059 0.0303

LEU 2059 ILE 2060 0.0334

ILE 2060 LYS 2061 0.0057

LYS 2061 GLU 2062 0.0177

GLU 2062 TYR 2063 0.0354

TYR 2063 LYS 2064 0.0229

LYS 2064 ILE 2065 0.0204

ILE 2065 PRO 2066 0.0091

PRO 2066 ASP 2067 0.0305

ASP 2067 ASP 2068 0.0170

ASP 2068 HIS 2069 0.0261

HIS 2069 ILE 2070 0.0388

ILE 2070 PHE 2071 0.0273

PHE 2071 SER 2072 0.0410

SER 2072 SER 2073 0.0330

SER 2073 ARG 2074 0.0295

ARG 2074 ASN 2075 0.0088

ASN 2075 ALA 2076 0.0357

ALA 2076 LEU 2077 -0.1209

LEU 2077 PHE 2078 0.0116

PHE 2078 ALA 2079 0.0258

ALA 2079 LYS 2080 0.0024

LYS 2080 SER 2081 0.0253

SER 2081 ILE 2082 0.0091

ILE 2082 ARG 2083 0.0199

ARG 2083 GLN 2084 0.0108

GLN 2084 ARG 2085 0.0152

ARG 2085 THR 2086 0.0196

THR 2086 ASN 2087 0.0067

ASN 2087 GLY 2088 0.0253

GLY 2088 LYS 2089 0.0043

LYS 2089 GLY 2090 0.0192

GLY 2090 VAL 2091 0.0028

VAL 2091 ASP 2092 0.0109

ASP 2092 VAL 2093 0.0847

VAL 2093 VAL 2094 0.0264

VAL 2094 LEU 2095 0.0138

LEU 2095 ASN 2096 0.0250

ASN 2096 CYS 2097 0.0240

CYS 2097 LEU 2098 0.0075

LEU 2098 ALA 2099 0.0266

ALA 2099 GLY 2100 0.0138

GLY 2100 GLY 2101 0.0048

GLY 2101 LEU 2102 0.0256

LEU 2102 LEU 2103 0.0126

LEU 2103 GLN 2104 0.0153

GLN 2104 GLU 2105 0.0159

GLU 2105 SER 2106 0.0118

SER 2106 PHE 2107 0.0255

PHE 2107 ASP 2108 0.0025

ASP 2108 CYS 2109 0.1189

CYS 2109 LEU 2110 0.0035

LEU 2110 ALA 2111 0.0056

ALA 2111 ASP 2112 0.0054

ASP 2112 PHE 2113 0.0017

PHE 2113 GLY 2114 0.0053

GLY 2114 ARG 2115 0.0030

ARG 2115 PHE 2116 0.0051

PHE 2116 ILE 2117 0.0019

ILE 2117 GLU 2118 0.0056

GLU 2118 ILE 2119 0.0023

ILE 2119 GLY 2120 0.0037

GLY 2120 LYS 2121 0.0056

LYS 2121 ARG 2122 0.0020

ARG 2122 ASP 2123 0.0026

ASP 2123 ILE 2124 0.0038

ILE 2124 GLU 2125 0.0957

GLU 2125 LEU 2126 0.0037

LEU 2126 ASN 2127 0.0046

ASN 2127 HIS 2128 0.0013

HIS 2128 CYS 2129 0.0018

CYS 2129 LEU 2130 0.0044

LEU 2130 ASN 2131 0.0001

ASN 2131 MET 2132 0.0058

MET 2132 GLY 2133 0.0006

GLY 2133 MET 2134 0.0055

MET 2134 PHE 2135 0.0050

PHE 2135 ALA 2136 0.0008

ALA 2136 ARG 2137 0.0058

ARG 2137 SER 2138 0.0023

SER 2138 ALA 2139 0.0042

ALA 2139 THR 2140 -0.0002

THR 2140 PHE 2141 -0.1401

PHE 2141 THR 2142 0.0035

THR 2142 ALA 2143 0.0052

ALA 2143 VAL 2144 0.0018

VAL 2144 ASP 2145 0.0057

ASP 2145 LEU 2146 0.0026

LEU 2146 ILE 2147 0.0097

ILE 2147 ALA 2148 0.0030

ALA 2148 ILE 2149 0.0101

ILE 2149 GLY 2150 0.0007

GLY 2150 ARG 2151 0.0096

ARG 2151 ASP 2152 0.0034

ASP 2152 ARG 2153 0.0100

ARG 2153 SER 2154 0.0007

SER 2154 TYR 2155 0.0101

TYR 2155 MET 2156 0.0089

MET 2156 PHE 2157 -0.0644

PHE 2157 ALA 2158 0.0134

ALA 2158 GLU 2159 0.0220

GLU 2159 ALA 2160 0.0242

ALA 2160 LEU 2161 0.0101

LEU 2161 PRO 2162 0.0117

PRO 2162 LYS 2163 0.0199

LYS 2163 ILE 2164 0.0248

ILE 2164 MET 2165 0.0011

MET 2165 THR 2166 0.0238

THR 2166 LEU 2167 0.0177

LEU 2167 LEU 2168 0.0195

LEU 2168 GLN 2169 0.0053

GLN 2169 GLU 2170 0.0239

GLU 2170 LYS 2171 0.0228

LYS 2171 ALA 2172 0.0060

ALA 2172 ILE 2173 0.0646

ILE 2173 ARG 2174 0.0189

ARG 2174 PRO 2175 0.0272

PRO 2175 VAL 2176 0.0219

VAL 2176 THR 2177 0.0217

THR 2177 PRO 2178 0.0221

PRO 2178 ILE 2179 0.0250

ILE 2179 SER 2180 0.0267

SER 2180 ILE 2181 0.0142

ILE 2181 TYR 2182 0.0273

TYR 2182 LYS 2183 0.0182

LYS 2183 ILE 2184 0.0217

ILE 2184 GLY 2185 0.0237

GLY 2185 ASP 2186 0.0203

ASP 2186 ILE 2187 0.0073

ILE 2187 GLU 2188 0.0204

GLU 2188 THR 2189 0.0038

THR 2189 ALA 2190 0.0274

ALA 2190 PHE 2191 0.0080

PHE 2191 ARG 2192 0.0286

ARG 2192 LEU 2193 0.0285

LEU 2193 MET 2194 0.0180

MET 2194 GLN 2195 0.0157

GLN 2195 ALA 2196 0.0296

ALA 2196 GLY 2197 0.0286

GLY 2197 LYS 2198 0.0130

LYS 2198 HIS 2199 0.0213

HIS 2199 MET 2200 0.0297

MET 2200 GLY 2201 0.0282

GLY 2201 LYS 2202 0.0268

LYS 2202 ILE 2203 0.0238

ILE 2203 VAL 2204 0.0154

VAL 2204 ILE 2205 0.1425

ILE 2205 THR 2206 0.0140

THR 2206 ALA 2207 0.0155

ALA 2207 PRO 2208 0.0147

PRO 2208 GLU 2209 0.0179

GLU 2209 ASP 2210 0.0130

ASP 2210 ALA 2211 0.0130

ALA 2211 MET 2212 0.0006

MET 2212 VAL 2213 0.0111

VAL 2213 PRO 2214 0.0001

PRO 2214 VAL 2215 0.0174

VAL 2215 ILE 2216 0.0035

ILE 2216 THR 2217 0.0179

THR 2217 ARG 2218 0.0136

ARG 2218 PRO 2219 0.0124

PRO 2219 PRO 2220 0.0168

PRO 2220 LYS 2221 0.6702

LYS 2221 LEU 2222 0.0084

LEU 2222 GLN 2223 0.0072

GLN 2223 LEU 2224 0.0088

LEU 2224 ARG 2225 0.0090

ARG 2225 PRO 2226 0.0029

PRO 2226 ASP 2227 0.0076

ASP 2227 ALA 2228 0.0038

ALA 2228 SER 2229 0.0088

SER 2229 TYR 2230 0.0075

TYR 2230 LEU 2231 0.0066

LEU 2231 ILE 2232 0.0092

ILE 2232 VAL 2233 0.0059

VAL 2233 GLY 2234 0.0075

GLY 2234 GLY 2235 0.0023

GLY 2235 LEU 2236 0.0067

LEU 2236 GLY 2237 0.1585

GLY 2237 GLY 2238 0.0129

GLY 2238 ILE 2239 0.0008

ILE 2239 GLY 2240 0.0131

GLY 2240 ARG 2241 0.0059

ARG 2241 SER 2242 0.0108

SER 2242 LEU 2243 0.0034

LEU 2243 CYS 2244 0.0100

CYS 2244 LYS 2245 0.0106

LYS 2245 ASN 2246 0.0034

ASN 2246 PHE 2247 0.0095

PHE 2247 VAL 2248 0.0076

VAL 2248 GLU 2249 0.0129

GLU 2249 ASN 2250 0.0001

ASN 2250 GLY 2251 0.0129

GLY 2251 ALA 2252 0.0126

ALA 2252 ARG 2253 -0.0709

ARG 2253 SER 2254 0.0142

SER 2254 LEU 2255 0.0156

LEU 2255 VAL 2256 0.0143

VAL 2256 LEU 2257 0.0134

LEU 2257 LEU 2258 0.0127

LEU 2258 SER 2259 0.0118

SER 2259 ARG 2260 0.0158

ARG 2260 ASN 2261 0.0003

ASN 2261 ALA 2262 0.0148

ALA 2262 ASN 2263 0.0047

ASN 2263 VAL 2264 0.0116

VAL 2264 SER 2265 0.0140

SER 2265 GLN 2266 0.0033

GLN 2266 GLN 2267 0.0144

GLN 2267 SER 2268 0.0097

SER 2268 GLY 2269 -0.1831

GLY 2269 GLU 2270 0.0462

GLU 2270 PHE 2271 0.0085

PHE 2271 LEU 2272 0.0386

LEU 2272 ASP 2273 0.0367

ASP 2273 GLU 2274 0.0423

GLU 2274 LEU 2275 0.0051

LEU 2275 ARG 2276 0.0463

ARG 2276 SER 2277 0.0394

SER 2277 THR 2278 0.0101

THR 2278 GLY 2279 0.0388

GLY 2279 CYS 2280 0.0394

CYS 2280 ILE 2281 0.0465

ILE 2281 VAL 2282 0.0392

VAL 2282 GLY 2283 0.0458

GLY 2283 VAL 2284 0.0320

VAL 2284 VAL 2285 0.1961

VAL 2285 ASP 2286 0.0118

ASP 2286 CYS 2287 0.0070

CYS 2287 ASP 2288 0.0114

ASP 2288 ILE 2289 0.0155

ILE 2289 SER 2290 0.0062

SER 2290 SER 2291 0.0136

SER 2291 LYS 2292 0.0137

LYS 2292 THR 2293 0.0164

THR 2293 GLN 2294 0.0010

GLN 2294 VAL 2295 0.0156

VAL 2295 GLU 2296 0.0118

GLU 2296 ALA 2297 0.0137

ALA 2297 THR 2298 0.0030

THR 2298 MET 2299 0.0161

MET 2299 LEU 2300 0.0146

LEU 2300 ARG 2301 0.1079

ARG 2301 LEU 2302 0.0067

LEU 2302 LYS 2303 0.0093

LYS 2303 LYS 2304 0.0080

LYS 2304 ASP 2305 0.0037

ASP 2305 MET 2306 0.0092

MET 2306 LEU 2307 0.0094

LEU 2307 PRO 2308 0.0037

PRO 2308 ILE 2309 0.0090

ILE 2309 ARG 2310 0.0095

ARG 2310 GLY 2311 0.0098

GLY 2311 ILE 2312 0.0081

ILE 2312 VAL 2313 0.0096

VAL 2313 HIS 2314 0.0052

HIS 2314 ALA 2315 0.0079

ALA 2315 GLY 2316 0.0064

GLY 2316 MET 2317 -0.1029

MET 2317 VAL 2318 0.0129

VAL 2318 LEU 2319 0.0339

LEU 2319 GLN 2320 0.0215

GLN 2320 ASP 2321 0.0295

ASP 2321 SER 2322 0.0316

SER 2322 VAL 2323 0.0260

VAL 2323 PHE 2324 0.0326

PHE 2324 GLU 2325 0.0223

GLU 2325 ARG 2326 0.0142

ARG 2326 MET 2327 0.0316

MET 2327 SER 2328 0.0183

SER 2328 LEU 2329 0.0314

LEU 2329 ASP 2330 0.0276

ASP 2330 ASP 2331 0.0255

ASP 2331 TYR 2332 0.0103

TYR 2332 ASN 2333 0.2640

ASN 2333 THR 2334 0.0123

THR 2334 ALA 2335 0.0019

ALA 2335 ILE 2336 0.0124

ILE 2336 ARG 2337 0.0117

ARG 2337 PRO 2338 0.0052

PRO 2338 LYS 2339 0.0069

LYS 2339 VAL 2340 0.0098

VAL 2340 GLN 2341 0.0081

GLN 2341 GLY 2342 0.0096

GLY 2342 SER 2343 0.0029

SER 2343 TRP 2344 0.0105

TRP 2344 ASN 2345 0.0106

ASN 2345 LEU 2346 0.0027

LEU 2346 HIS 2347 0.0110

HIS 2347 SER 2348 0.0068

SER 2348 GLY 2349 0.1043

GLY 2349 LEU 2350 0.0008

LEU 2350 SER 2351 0.0132

SER 2351 ASP 2352 0.0127

ASP 2352 CYS 2353 0.0045

CYS 2353 ASP 2354 0.0024

ASP 2354 LEU 2355 0.0121

LEU 2355 ASP 2356 0.0009

ASP 2356 PHE 2357 0.0119

PHE 2357 PHE 2358 0.0043

PHE 2358 ILE 2359 0.0130

ILE 2359 MET 2360 0.0073

MET 2360 LEU 2361 0.0126

LEU 2361 SER 2362 0.0107

SER 2362 SER 2363 0.0132

SER 2363 LEU 2364 0.0103

LEU 2364 ALA 2365 -0.1748

ALA 2365 GLY 2366 0.0186

GLY 2366 VAL 2367 0.0038

VAL 2367 SER 2368 0.0189

SER 2368 GLY 2369 0.0033

GLY 2369 SER 2370 0.0087

SER 2370 ALA 2371 0.0096

ALA 2371 SER 2372 0.0043

SER 2372 GLN 2373 0.0161

GLN 2373 ALA 2374 0.0190

ALA 2374 ASN 2375 0.0166

ASN 2375 TYR 2376 0.0143

TYR 2376 THR 2377 0.0058

THR 2377 ALA 2378 0.0194

ALA 2378 GLY 2379 0.0194

GLY 2379 GLY 2380 0.0057

GLY 2380 ALA 2381 0.0539

ALA 2381 TYR 2382 0.0092

TYR 2382 GLN 2383 0.0057

GLN 2383 ASP 2384 0.0050

ASP 2384 ALA 2385 0.0092

ALA 2385 LEU 2386 0.0105

LEU 2386 ALA 2387 0.0010

ALA 2387 LYS 2388 0.0099

LYS 2388 TYR 2389 0.0066

TYR 2389 ARG 2390 0.0091

ARG 2390 ARG 2391 0.0013

ARG 2391 ALA 2392 0.0098

ALA 2392 GLN 2393 0.0097

GLN 2393 GLY 2394 0.0024

GLY 2394 LEU 2395 0.0089

LEU 2395 SER 2396 0.0094

SER 2396 ALA 2397 0.0615

ALA 2397 VAL 2398 0.0020

VAL 2398 SER 2399 0.0012

SER 2399 ILE 2400 0.0016

ILE 2400 ASP 2401 0.0012

ASP 2401 LEU 2402 0.0016

LEU 2402 GLY 2403 0.0020

GLY 2403 MET 2404 0.0021

MET 2404 VAL 2405 0.0011

VAL 2405 GLN 2406 0.0017

GLN 2406 SER 2407 0.0015

SER 2407 VAL 2408 0.0015

VAL 2408 GLY 2409 0.0002

GLY 2409 TYR 2410 0.0005

TYR 2410 VAL 2411 0.0018

VAL 2411 ALA 2412 0.0010

ALA 2412 GLU 2413 0.0956

GLU 2413 THR 2414 0.0006

THR 2414 LYS 2415 0.0061

LYS 2415 GLY 2416 0.0054

GLY 2416 VAL 2417 0.0064

VAL 2417 ALA 2418 0.0040

ALA 2418 GLU 2419 0.0042

GLU 2419 ARG 2420 0.0042

ARG 2420 LEU 2421 0.0038

LEU 2421 VAL 2422 0.0065

VAL 2422 ARG 2423 0.0006

ARG 2423 MET 2424 0.0073

MET 2424 GLY 2425 0.0028

GLY 2425 TYR 2426 0.0035

TYR 2426 SER 2427 0.0018

SER 2427 PRO 2428 0.0056

PRO 2428 ILE 2429 -0.0146

ILE 2429 SER 2430 0.0124

SER 2430 GLU 2431 0.0081

GLU 2431 MET 2432 0.0102

MET 2432 GLU 2433 0.0155

GLU 2433 VAL 2434 0.0172

VAL 2434 LEU 2435 0.0020

LEU 2435 LYS 2436 0.0165

LYS 2436 ILE 2437 0.0146

ILE 2437 VAL 2438 0.0121

VAL 2438 GLU 2439 0.0062

GLU 2439 HIS 2440 0.0168

HIS 2440 ALA 2441 0.0170

ALA 2441 ILE 2442 0.0035

ILE 2442 THR 2443 0.0135

THR 2443 ASN 2444 0.0137

ASN 2444 PRO 2445 0.3593

PRO 2445 PRO 2446 0.0076

PRO 2446 PRO 2447 0.0076

PRO 2447 GLU 2448 0.0062

GLU 2448 ALA 2449 0.0019

ALA 2449 SER 2450 0.0059

SER 2450 SER 2451 0.0054

SER 2451 ALA 2452 0.0032

ALA 2452 GLN 2453 0.0076

GLN 2453 ILE 2454 0.0036

ILE 2454 ILE 2455 0.0075

ILE 2455 THR 2456 0.0065

THR 2456 GLY 2457 0.0073

GLY 2457 ILE 2458 0.0068

ILE 2458 SER 2459 0.0024

SER 2459 THR 2460 0.0032

THR 2460 LYS 2461 0.0588

LYS 2461 PRO 2462 0.0143

PRO 2462 GLY 2463 0.0166

GLY 2463 ARG 2464 0.0149

ARG 2464 HIS 2465 0.0035

HIS 2465 TRP 2466 0.0176

TRP 2466 THR 2467 0.0176

THR 2467 GLU 2468 0.0133

GLU 2468 SER 2469 0.0078

SER 2469 SER 2470 0.0076

SER 2470 TRP 2471 0.0145

TRP 2471 LEU 2472 0.0057

LEU 2472 GLN 2473 0.0175

GLN 2473 ASP 2474 0.0053

ASP 2474 ALA 2475 0.0176

ALA 2475 ARG 2476 0.0167

ARG 2476 PHE 2477 0.0213

PHE 2477 ALA 2478 0.0192

ALA 2478 THR 2479 0.0193

THR 2479 LEU 2480 0.0140

LEU 2480 ARG 2481 0.0179

ARG 2481 GLU 2482 0.0187

GLU 2482 ARG 2483 0.0183

ARG 2483 ALA 2484 0.0162

ALA 2484 ARG 2485 0.0190

ARG 2485 ASP 2486 0.0195

ASP 2486 VAL 2487 0.0157

VAL 2487 LYS 2488 0.0177

LYS 2488 GLU 2489 0.0201

GLU 2489 LEU 2490 0.0193

LEU 2490 SER 2491 0.0121

SER 2491 ASN 2492 0.0186

ASN 2492 SER 2493 0.1005

SER 2493 GLN 2494 0.0837

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** sdgklnrdh ***

CA strain for 22101813491974862

--- normal mode 29 ---

Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *