Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *

CA strain for 22101813491974862

--- normal mode 23 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
ASN 989 LYS 990 0.0070

LYS 990 ALA 991 0.0079

ALA 991 HIS 992 0.0066

HIS 992 ARG 993 0.0035

ARG 993 GLN 994 0.0078

GLN 994 ARG 995 0.0080

ARG 995 VAL 996 0.0050

VAL 996 HIS 997 0.0077

HIS 997 PRO 998 0.0073

PRO 998 PRO 999 0.0062

PRO 999 HIS 1000 0.0077

HIS 1000 ASP 1001 0.0074

ASP 1001 LEU 1002 0.0040

LEU 1002 LEU 1003 0.0040

LEU 1003 GLY 1004 0.0080

GLY 1004 SER 1005 -0.0353

SER 1005 LEU 1006 0.0026

LEU 1006 ILE 1007 0.0002

ILE 1007 VAL 1008 0.0036

VAL 1008 GLY 1009 0.0015

GLY 1009 ARG 1010 0.0033

ARG 1010 ASP 1011 0.0037

ASP 1011 LEU 1012 0.0002

LEU 1012 ARG 1013 0.0032

ARG 1013 GLU 1014 0.0032

GLU 1014 PRO 1015 0.0023

PRO 1015 THR 1016 0.0035

THR 1016 TRP 1017 0.0019

TRP 1017 ARG 1018 0.0032

ARG 1018 HIS 1019 0.0020

HIS 1019 PHE 1020 0.0036

PHE 1020 ILE 1021 -0.0191

ILE 1021 ARG 1022 0.0043

ARG 1022 VAL 1023 0.0041

VAL 1023 GLN 1024 0.0059

GLN 1024 ASP 1025 0.0091

ASP 1025 ILE 1026 0.0100

ILE 1026 PRO 1027 0.0050

PRO 1027 TRP 1028 0.0099

TRP 1028 ILE 1029 0.0024

ILE 1029 ARG 1030 0.0069

ARG 1030 ASP 1031 0.0091

ASP 1031 HIS 1032 0.0012

HIS 1032 VAL 1033 0.0090

VAL 1033 VAL 1034 0.0044

VAL 1034 GLN 1035 0.0098

GLN 1035 SER 1036 0.0060

SER 1036 ALA 1037 -0.0324

ALA 1037 LEU 1038 0.0050

LEU 1038 VAL 1039 0.0023

VAL 1039 TYR 1040 0.0056

TYR 1040 PRO 1041 0.0053

PRO 1041 GLY 1042 0.0009

GLY 1042 ALA 1043 0.0047

ALA 1043 GLY 1044 0.0053

GLY 1044 PHE 1045 0.0003

PHE 1045 ILE 1046 0.0055

ILE 1046 CYS 1047 0.0020

CYS 1047 MET 1048 0.0047

MET 1048 ALA 1049 0.0015

ALA 1049 MET 1050 0.0042

MET 1050 GLU 1051 0.0041

GLU 1051 ALA 1052 0.0015

ALA 1052 MET 1053 -0.0044

MET 1053 VAL 1054 0.0002

VAL 1054 GLN 1055 0.0061

GLN 1055 LEU 1056 0.0032

LEU 1056 HIS 1057 0.0038

HIS 1057 GLU 1058 0.0026

GLU 1058 LEU 1059 0.0044

LEU 1059 ARG 1060 0.0056

ARG 1060 ASP 1061 0.0031

ASP 1061 SER 1062 0.0018

SER 1062 GLN 1063 0.0061

GLN 1063 SER 1064 0.0050

SER 1064 ARG 1065 0.0039

ARG 1065 LYS 1066 0.0055

LYS 1066 VAL 1067 0.0028

VAL 1067 ALA 1068 0.0063

ALA 1068 GLY 1069 -0.0109

GLY 1069 TYR 1070 0.0033

TYR 1070 ARG 1071 0.0016

ARG 1071 LEU 1072 0.0038

LEU 1072 ALA 1073 0.0016

ALA 1073 GLU 1074 0.0035

GLU 1074 VAL 1075 0.0013

VAL 1075 ASP 1076 0.0042

ASP 1076 ILE 1077 0.0018

ILE 1077 LEU 1078 0.0029

LEU 1078 ARG 1079 0.0020

ARG 1079 ALA 1080 -0.0002

ALA 1080 MET 1081 0.0036

MET 1081 LEU 1082 0.0024

LEU 1082 ILE 1083 0.0015

ILE 1083 PRO 1084 0.0037

PRO 1084 ASP 1085 -0.0165

ASP 1085 THR 1086 0.0033

THR 1086 SER 1087 0.0029

SER 1087 GLU 1088 0.0018

GLU 1088 GLY 1089 0.0033

GLY 1089 LEU 1090 0.0022

LEU 1090 GLU 1091 0.0031

GLU 1091 ALA 1092 0.0033

ALA 1092 HIS 1093 0.0031

HIS 1093 ILE 1094 0.0033

ILE 1094 SER 1095 0.0025

SER 1095 LEU 1096 0.0032

LEU 1096 ARG 1097 0.0018

ARG 1097 PRO 1098 0.0034

PRO 1098 CYS 1099 0.0029

CYS 1099 SER 1100 0.0014

SER 1100 THR 1101 -0.0353

THR 1101 LYS 1102 0.0007

LYS 1102 LEU 1103 0.0020

LEU 1103 LEU 1104 0.0017

LEU 1104 LEU 1105 0.0011

LEU 1105 THR 1106 0.0003

THR 1106 ASN 1107 0.0021

ASN 1107 GLU 1108 0.0022

GLU 1108 TRP 1109 0.0013

TRP 1109 TYR 1110 0.0021

TYR 1110 ASP 1111 0.0004

ASP 1111 PHE 1112 0.0019

PHE 1112 CYS 1113 0.0012

CYS 1113 VAL 1114 0.0022

VAL 1114 SER 1115 0.0009

SER 1115 SER 1116 0.0022

SER 1116 VAL 1117 0.0167

VAL 1117 GLY 1118 0.0018

GLY 1118 ASP 1119 0.0019

ASP 1119 ASP 1120 -0.0001

ASP 1120 ASP 1121 0.0020

ASP 1121 LYS 1122 0.0017

LYS 1122 PHE 1123 0.0016

PHE 1123 VAL 1124 0.0017

VAL 1124 ASP 1125 0.0017

ASP 1125 HIS 1126 0.0007

HIS 1126 CYS 1127 0.0020

CYS 1127 ARG 1128 0.0011

ARG 1128 GLY 1129 0.0019

GLY 1129 ARG 1130 0.0018

ARG 1130 ILE 1131 0.0010

ILE 1131 THR 1132 0.0016

THR 1132 ILE 1133 0.0431

ILE 1133 GLU 1134 0.0087

GLU 1134 PHE 1135 0.0187

PHE 1135 ASP 1136 0.0163

ASP 1136 THR 1137 0.0115

THR 1137 SER 1138 0.0193

SER 1138 GLY 1139 0.0004

GLY 1139 SER 1140 0.0166

SER 1140 ALA 1141 0.0160

ALA 1141 ASP 1142 0.0198

ASP 1142 THR 1143 0.0135

THR 1143 PRO 1144 0.0194

PRO 1144 ARG 1145 0.0157

ARG 1145 THR 1146 0.0098

THR 1146 SER 1147 0.0188

SER 1147 LEU 1148 0.0195

LEU 1148 ARG 1149 0.1540

ARG 1149 GLU 1150 0.0510

GLU 1150 ARG 1151 0.0529

ARG 1151 SER 1152 0.0338

SER 1152 ARG 1153 0.0683

ARG 1153 SER 1154 0.0635

SER 1154 THR 1155 0.0619

THR 1155 GLY 1156 0.0049

GLY 1156 LEU 1157 0.0197

LEU 1157 MET 1158 0.0743

MET 1158 ARG 1159 0.0034

ARG 1159 SER 1160 0.0701

SER 1160 VAL 1161 0.0533

VAL 1161 ASP 1162 0.0519

ASP 1162 PRO 1163 0.0800

PRO 1163 SER 1164 0.0035

SER 1164 ASN 1165 0.0073

ASN 1165 LEU 1166 0.0003

LEU 1166 TYR 1167 0.0102

TYR 1167 SER 1168 0.0039

SER 1168 PHE 1169 0.0084

PHE 1169 LEU 1170 0.0019

LEU 1170 ARG 1171 0.0082

ARG 1171 ALA 1172 0.0084

ALA 1172 GLN 1173 0.0019

GLN 1173 GLY 1174 0.0094

GLY 1174 ILE 1175 0.0085

ILE 1175 TYR 1176 0.0080

TYR 1176 HIS 1177 0.0100

HIS 1177 GLY 1178 0.0082

GLY 1178 PRO 1179 0.0093

PRO 1179 ILE 1180 0.0020

ILE 1180 PHE 1181 0.0776

PHE 1181 GLN 1182 0.0139

GLN 1182 ASN 1183 0.0100

ASN 1183 LEU 1184 0.0170

LEU 1184 LYS 1185 0.0161

LYS 1185 THR 1186 0.0157

THR 1186 ILE 1187 0.0157

ILE 1187 SER 1188 0.0143

SER 1188 SER 1189 0.0162

SER 1189 ARG 1190 0.0146

ARG 1190 LYS 1191 0.0165

LYS 1191 ASP 1192 0.0058

ASP 1192 HIS 1193 0.0175

HIS 1193 SER 1194 0.0116

SER 1194 GLU 1195 0.0176

GLU 1195 SER 1196 0.0112

SER 1196 SER 1197 -0.0610

SER 1197 PHE 1198 0.0103

PHE 1198 VAL 1199 0.0093

VAL 1199 VAL 1200 0.0105

VAL 1200 ALA 1201 0.0066

ALA 1201 ASN 1202 0.0078

ASN 1202 THR 1203 0.0097

THR 1203 ALA 1204 0.0104

ALA 1204 SER 1205 0.0013

SER 1205 VAL 1206 0.0115

VAL 1206 MET 1207 0.0083

MET 1207 PRO 1208 0.0087

PRO 1208 ASN 1209 0.0098

ASN 1209 GLY 1210 0.0096

GLY 1210 PHE 1211 0.0029

PHE 1211 GLN 1212 0.0029

GLN 1212 SER 1213 0.0070

SER 1213 PRO 1214 0.0099

PRO 1214 HIS 1215 0.0080

HIS 1215 VAL 1216 0.0078

VAL 1216 ILE 1217 0.0094

ILE 1217 HIS 1218 0.0063

HIS 1218 PRO 1219 0.0112

PRO 1219 THR 1220 0.0037

THR 1220 THR 1221 0.0109

THR 1221 LEU 1222 0.0017

LEU 1222 ASP 1223 0.0100

ASP 1223 SER 1224 0.0073

SER 1224 ILE 1225 0.0035

ILE 1225 PHE 1226 0.0102

PHE 1226 GLN 1227 0.0029

GLN 1227 GLY 1228 0.0115

GLY 1228 ALA 1229 -0.0783

ALA 1229 TYR 1230 0.0017

TYR 1230 THR 1231 0.0069

THR 1231 ALA 1232 0.0047

ALA 1232 LEU 1233 0.0060

LEU 1233 PRO 1234 0.0037

PRO 1234 GLY 1235 0.0021

GLY 1235 ALA 1236 0.0053

ALA 1236 GLY 1237 0.0075

GLY 1237 LEU 1238 0.0004

LEU 1238 ASP 1239 0.0078

ASP 1239 GLN 1240 0.0047

GLN 1240 ASN 1241 0.0072

ASN 1241 THR 1242 0.0053

THR 1242 ALA 1243 0.0065

ALA 1243 MET 1244 0.0008

MET 1244 ILE 1245 -0.0388

ILE 1245 PRO 1246 0.0042

PRO 1246 ARG 1247 0.0016

ARG 1247 SER 1248 0.0042

SER 1248 ILE 1249 0.0068

ILE 1249 GLN 1250 0.0014

GLN 1250 GLU 1251 0.0066

GLU 1251 LEU 1252 0.0021

LEU 1252 TYR 1253 0.0069

TYR 1253 LEU 1254 0.0026

LEU 1254 SER 1255 0.0069

SER 1255 SER 1256 0.0059

SER 1256 ALA 1257 0.0046

ALA 1257 LEU 1258 0.0049

LEU 1258 THR 1259 0.0016

THR 1259 SER 1260 0.0052

SER 1260 ASP 1261 0.0587

ASP 1261 VAL 1262 0.0009

VAL 1262 GLY 1263 0.0058

GLY 1263 GLN 1264 0.0032

GLN 1264 CYS 1265 0.0080

CYS 1265 LEU 1266 0.0047

LEU 1266 VAL 1267 0.0083

VAL 1267 SER 1268 0.0074

SER 1268 ASP 1269 0.0079

ASP 1269 THR 1270 0.0084

THR 1270 SER 1271 0.0075

SER 1271 LEU 1272 0.0080

LEU 1272 ILE 1273 0.0029

ILE 1273 ARG 1274 0.0069

ARG 1274 TYR 1275 0.0018

TYR 1275 ASP 1276 0.0077

ASP 1276 GLY 1277 0.0384

GLY 1277 GLN 1278 0.0074

GLN 1278 SER 1279 0.0053

SER 1279 PHE 1280 0.0081

PHE 1280 THR 1281 0.0041

THR 1281 VAL 1282 0.0084

VAL 1282 ASN 1283 0.0065

ASN 1283 VAL 1284 0.0063

VAL 1284 ASP 1285 0.0081

ASP 1285 VAL 1286 0.0057

VAL 1286 SER 1287 0.0085

SER 1287 SER 1288 0.0057

SER 1288 LYS 1289 0.0042

LYS 1289 ALA 1290 0.0081

ALA 1290 ASP 1291 0.0007

ASP 1291 SER 1292 0.0085

SER 1292 GLU 1293 0.0515

GLU 1293 HIS 1294 0.0069

HIS 1294 THR 1295 0.0030

THR 1295 PRO 1296 0.0081

PRO 1296 VAL 1297 0.0076

VAL 1297 LEU 1298 0.0079

LEU 1298 GLU 1299 0.0060

GLU 1299 ILE 1300 0.0080

ILE 1300 LYS 1301 0.0052

LYS 1301 GLY 1302 0.0076

GLY 1302 LEU 1303 0.0022

LEU 1303 ARG 1304 0.0079

ARG 1304 ASN 1305 0.0011

ASN 1305 GLN 1306 0.0078

GLN 1306 SER 1307 0.0028

SER 1307 VAL 1308 0.0071

VAL 1308 GLY 1309 -0.5145

GLY 1309 GLN 1310 0.0163

GLN 1310 MET 1311 0.0103

MET 1311 ALA 1312 0.0132

ALA 1312 PRO 1313 0.0127

PRO 1313 GLN 1314 0.0092

GLN 1314 PRO 1315 0.0129

PRO 1315 GLY 1316 0.0091

GLY 1316 ASP 1317 0.0058

ASP 1317 SER 1318 0.0155

SER 1318 SER 1319 0.0005

SER 1319 ASN 1320 0.0161

ASN 1320 ASN 1321 0.0158

ASN 1321 ASP 1322 0.0162

ASP 1322 LEU 1323 0.0019

LEU 1323 CYS 1324 0.0150

CYS 1324 PHE 1325 0.0923

PHE 1325 LYS 1326 0.0165

LYS 1326 LEU 1327 0.0169

LEU 1327 ASP 1328 0.0178

ASP 1328 TRP 1329 0.0188

TRP 1329 ALA 1330 0.0191

ALA 1330 PRO 1331 0.0183

PRO 1331 ASP 1332 0.0011

ASP 1332 ILE 1333 0.0188

ILE 1333 SER 1334 0.0074

SER 1334 SER 1335 0.0129

SER 1335 VAL 1336 0.0049

VAL 1336 LYS 1337 0.0166

LYS 1337 GLN 1338 0.0171

GLN 1338 GLU 1339 0.0041

GLU 1339 ARG 1340 0.0178

ARG 1340 LEU 1341 0.4292

LEU 1341 LYS 1342 0.0465

LYS 1342 GLU 1343 0.0647

GLU 1343 LYS 1344 0.0611

LYS 1344 PHE 1345 0.0457

PHE 1345 GLY 1346 0.0583

GLY 1346 PHE 1347 0.0041

PHE 1347 PRO 1348 0.0573

PRO 1348 LEU 1349 0.0305

LEU 1349 ASP 1350 0.0127

ASP 1350 PRO 1351 0.0429

PRO 1351 THR 1352 0.0254

THR 1352 GLU 1353 0.0514

GLU 1353 ALA 1354 0.0611

ALA 1354 ASP 1355 0.0036

ASP 1355 ILE 1356 0.0619

ILE 1356 ILE 1357 0.4223

ILE 1357 MET 1358 0.2181

MET 1358 GLY 1359 0.1994

GLY 1359 LEU 1360 0.1487

LEU 1360 ARG 1361 0.2785

ARG 1361 GLN 1362 0.0541

GLN 1362 ALA 1363 0.2984

ALA 1363 CYS 1364 0.0867

CYS 1364 ILE 1365 0.2824

ILE 1365 HIS 1366 0.1121

HIS 1366 PHE 1367 0.2382

PHE 1367 ILE 1368 0.1908

ILE 1368 HIS 1369 0.1782

HIS 1369 ARG 1370 0.2342

ARG 1370 SER 1371 0.1265

SER 1371 LEU 1372 0.2756

LEU 1372 GLN 1373 0.0909

GLN 1373 SER 1374 0.3344

SER 1374 LEU 1375 0.0482

LEU 1375 THR 1376 0.3347

THR 1376 ALA 1377 0.1610

ALA 1377 PRO 1378 0.3157

PRO 1378 ASP 1379 0.3337

ASP 1379 ARG 1380 0.2289

ARG 1380 ASP 1381 0.2125

ASP 1381 GLN 1382 0.3344

GLN 1382 LEU 1383 0.3264

LEU 1383 ASP 1384 0.1147

ASP 1384 TRP 1385 0.2049

TRP 1385 HIS 1386 0.3121

HIS 1386 GLN 1387 0.0333

GLN 1387 LYS 1388 0.3208

LYS 1388 ARG 1389 0.1747

ARG 1389 PHE 1390 0.1046

PHE 1390 TYR 1391 0.2685

TYR 1391 ASP 1392 0.2548

ASP 1392 TRP 1393 0.3139

TRP 1393 MET 1394 0.0261

MET 1394 VAL 1395 0.3238

VAL 1395 LEU 1396 0.2752

LEU 1396 GLN 1397 0.1967

GLN 1397 ILE 1398 0.1766

ILE 1398 GLN 1399 0.2670

GLN 1399 LEU 1400 0.3210

LEU 1400 ALA 1401 0.0266

ALA 1401 GLU 1402 0.3101

GLU 1402 GLU 1403 0.2339

GLU 1403 ASP 1404 0.2720

ASP 1404 ARG 1405 -0.0647

ARG 1405 LEU 1406 0.3130

LEU 1406 ALA 1407 0.2152

ALA 1407 PRO 1408 0.2304

PRO 1408 ASN 1409 0.1911

ASN 1409 SER 1410 0.2787

SER 1410 SER 1411 0.2991

SER 1411 ALA 1412 0.0644

ALA 1412 TRP 1413 0.3001

TRP 1413 LEU 1414 0.3217

LEU 1414 GLN 1415 0.0224

GLN 1415 CYS 1416 0.2901

CYS 1416 SER 1417 0.1113

SER 1417 SER 1418 0.3205

SER 1418 SER 1419 0.2395

SER 1419 ASP 1420 0.2352

ASP 1420 GLU 1421 0.1163

GLU 1421 GLN 1422 0.2726

GLN 1422 LYS 1423 0.2892

LYS 1423 LEU 1424 0.0728

LEU 1424 LEU 1425 0.2505

LEU 1425 GLU 1426 0.2382

GLU 1426 ASN 1427 0.2816

ASN 1427 VAL 1428 0.0368

VAL 1428 ARG 1429 0.2946

ARG 1429 ALA 1430 0.2643

ALA 1430 SER 1431 0.2239

SER 1431 SER 1432 0.0600

SER 1432 VAL 1433 0.2118

VAL 1433 ASN 1434 0.2758

ASN 1434 GLY 1435 0.0385

GLY 1435 GLN 1436 0.2941

GLN 1436 MET 1437 0.1010

MET 1437 VAL 1438 0.2723

VAL 1438 VAL 1439 0.0528

VAL 1439 HIS 1440 0.2615

HIS 1440 VAL 1441 0.1631

VAL 1441 GLY 1442 0.2262

GLY 1442 LYS 1443 0.1254

LYS 1443 SER 1444 0.1977

SER 1444 MET 1445 0.2050

MET 1445 LEU 1446 0.2573

LEU 1446 ALA 1447 0.2833

ALA 1447 ILE 1448 0.0435

ILE 1448 LEU 1449 0.2755

LEU 1449 ARG 1450 0.2533

ARG 1450 HIS 1451 0.2058

HIS 1451 GLU 1452 0.1193

GLU 1452 ILE 1453 0.5527

ILE 1453 ALA 1454 0.0626

ALA 1454 PRO 1455 0.2521

PRO 1455 LEU 1456 0.1803

LEU 1456 GLU 1457 0.1898

GLU 1457 LEU 1458 0.0978

LEU 1458 MET 1459 0.2169

MET 1459 LEU 1460 0.2372

LEU 1460 GLN 1461 0.0381

GLN 1461 ASP 1462 0.2220

ASP 1462 LYS 1463 0.0628

LYS 1463 LEU 1464 0.2338

LEU 1464 LEU 1465 0.0390

LEU 1465 TYR 1466 0.2353

TYR 1466 ARG 1467 0.1218

ARG 1467 TYR 1468 0.2414

TYR 1468 TYR 1469 0.2662

TYR 1469 THR 1470 0.0933

THR 1470 ASP 1471 0.0223

ASP 1471 ALA 1472 0.0888

ALA 1472 ILE 1473 0.0931

ILE 1473 LYS 1474 0.0301

LYS 1474 TRP 1475 0.0599

TRP 1475 ASP 1476 0.0921

ASP 1476 ARG 1477 0.0868

ARG 1477 SER 1478 0.0522

SER 1478 TYR 1479 0.0845

TYR 1479 GLN 1480 0.0934

GLN 1480 GLN 1481 0.0686

GLN 1481 ILE 1482 0.0649

ILE 1482 ASP 1483 0.0933

ASP 1483 GLN 1484 0.0832

GLN 1484 LEU 1485 0.2963

LEU 1485 VAL 1486 0.0157

VAL 1486 LYS 1487 0.0077

LYS 1487 LEU 1488 0.0103

LEU 1488 HIS 1489 0.0146

HIS 1489 ALA 1490 0.0154

ALA 1490 HIS 1491 0.0033

HIS 1491 LYS 1492 0.0145

LYS 1492 CYS 1493 0.0129

CYS 1493 PRO 1494 0.0154

PRO 1494 THR 1495 0.0150

THR 1495 ALA 1496 0.0071

ALA 1496 LYS 1497 0.0067

LYS 1497 ILE 1498 0.0060

ILE 1498 ILE 1499 0.0017

ILE 1499 GLU 1500 0.0063

GLU 1500 ILE 1501 0.2641

ILE 1501 GLY 1502 0.0029

GLY 1502 ALA 1503 0.0283

ALA 1503 GLY 1504 0.0075

GLY 1504 THR 1505 0.0190

THR 1505 GLY 1506 0.0157

GLY 1506 GLY 1507 0.0242

GLY 1507 CYS 1508 0.0077

CYS 1508 THR 1509 0.0222

THR 1509 ARG 1510 0.0233

ARG 1510 ALA 1511 0.0278

ALA 1511 VAL 1512 0.0042

VAL 1512 LEU 1513 0.0294

LEU 1513 ASP 1514 0.0250

ASP 1514 ALA 1515 0.0165

ALA 1515 LEU 1516 0.0140

LEU 1516 SER 1517 -0.0802

SER 1517 ASN 1518 0.0131

ASN 1518 GLN 1519 0.0081

GLN 1519 GLY 1520 0.0139

GLY 1520 ILE 1521 0.0013

ILE 1521 ALA 1522 0.0136

ALA 1522 ARG 1523 0.0056

ARG 1523 CYS 1524 0.0135

CYS 1524 ALA 1525 0.0114

ALA 1525 GLN 1526 0.0076

GLN 1526 TYR 1527 0.0049

TYR 1527 ASP 1528 0.0131

ASP 1528 PHE 1529 0.0008

PHE 1529 THR 1530 0.0137

THR 1530 ASP 1531 0.0067

ASP 1531 VAL 1532 0.0136

VAL 1532 SER 1533 -0.0537

SER 1533 SER 1534 0.0228

SER 1534 GLY 1535 0.0009

GLY 1535 PHE 1536 0.0224

PHE 1536 PHE 1537 0.0089

PHE 1537 GLU 1538 0.0167

GLU 1538 ALA 1539 0.0157

ALA 1539 ALA 1540 0.0079

ALA 1540 GLN 1541 0.0173

GLN 1541 GLN 1542 0.0094

GLN 1542 LYS 1543 0.0229

LYS 1543 PHE 1544 0.0011

PHE 1544 ALA 1545 0.0217

ALA 1545 ALA 1546 0.0192

ALA 1546 PHE 1547 0.0110

PHE 1547 ASP 1548 0.0225

ASP 1548 ASP 1549 0.2355

ASP 1549 VAL 1550 0.0249

VAL 1550 ILE 1551 0.0206

ILE 1551 ARG 1552 0.0324

ARG 1552 PHE 1553 0.0179

PHE 1553 GLN 1554 0.0295

GLN 1554 LYS 1555 0.0307

LYS 1555 LEU 1556 0.0189

LEU 1556 ASP 1557 0.0323

ASP 1557 ILE 1558 0.0136

ILE 1558 GLU 1559 0.0322

GLU 1559 LYS 1560 0.0307

LYS 1560 ASP 1561 0.0081

ASP 1561 ILE 1562 0.0324

ILE 1562 GLU 1563 0.0254

GLU 1563 MET 1564 0.0169

MET 1564 GLN 1565 0.0018

GLN 1565 GLY 1566 0.0282

GLY 1566 PHE 1567 0.0331

PHE 1567 GLU 1568 0.0128

GLU 1568 CYS 1569 0.0308

CYS 1569 GLY 1570 0.0332

GLY 1570 SER 1571 0.0273

SER 1571 TYR 1572 0.0076

TYR 1572 ASP 1573 0.0320

ASP 1573 LEU 1574 0.0065

LEU 1574 VAL 1575 0.0291

VAL 1575 ILE 1576 0.0006

ILE 1576 ALA 1577 0.0278

ALA 1577 SER 1578 0.0012

SER 1578 GLN 1579 0.0281

GLN 1579 VAL 1580 0.0192

VAL 1580 LEU 1581 0.2185

LEU 1581 HIS 1582 0.0660

HIS 1582 ALA 1583 0.0777

ALA 1583 THR 1584 0.0006

THR 1584 GLY 1585 0.0499

GLY 1585 LYS 1586 0.0539

LYS 1586 MET 1587 0.0708

MET 1587 GLU 1588 0.0171

GLU 1588 HIS 1589 0.0707

HIS 1589 THR 1590 0.0266

THR 1590 MET 1591 0.0777

MET 1591 ALA 1592 0.0037

ALA 1592 ASN 1593 0.0730

ASN 1593 VAL 1594 0.0365

VAL 1594 ARG 1595 0.0453

ARG 1595 LYS 1596 0.0537

LYS 1596 LEU 1597 -0.1778

LEU 1597 LEU 1598 0.0718

LEU 1598 LYS 1599 0.0343

LYS 1599 PRO 1600 0.0593

PRO 1600 GLY 1601 0.0420

GLY 1601 GLY 1602 0.0349

GLY 1602 LYS 1603 0.0130

LYS 1603 LEU 1604 0.0510

LEU 1604 LEU 1605 0.0022

LEU 1605 LEU 1606 0.0558

LEU 1606 VAL 1607 0.0033

VAL 1607 GLU 1608 0.0723

GLU 1608 THR 1609 0.0449

THR 1609 THR 1610 0.0607

THR 1610 ARG 1611 0.0285

ARG 1611 ASP 1612 0.0493

ASP 1612 GLU 1613 -0.0264

GLU 1613 MET 1614 0.1917

MET 1614 ASP 1615 0.2347

ASP 1615 LEU 1616 0.0483

LEU 1616 GLN 1617 0.2368

GLN 1617 LEU 1618 0.1108

LEU 1618 VAL 1619 0.2576

VAL 1619 PHE 1620 0.0069

PHE 1620 GLY 1621 0.2544

GLY 1621 LEU 1622 0.2388

LEU 1622 LEU 1623 0.1038

LEU 1623 PRO 1624 0.0764

PRO 1624 GLY 1625 0.2098

GLY 1625 TRP 1626 0.2153

TRP 1626 TRP 1627 0.2183

TRP 1627 LEU 1628 0.0388

LEU 1628 SER 1629 -0.0225

SER 1629 SER 1630 0.0974

SER 1630 GLU 1631 0.1695

GLU 1631 GLU 1632 0.1395

GLU 1632 GLU 1633 0.1206

GLU 1633 ARG 1634 0.1566

ARG 1634 GLN 1635 0.1647

GLN 1635 MET 1636 0.0112

MET 1636 SER 1637 0.1700

SER 1637 PRO 1638 0.1218

PRO 1638 SER 1639 0.1660

SER 1639 LEU 1640 0.1302

LEU 1640 SER 1641 0.1510

SER 1641 THR 1642 0.1609

THR 1642 ASN 1643 0.1217

ASN 1643 SER 1644 0.1366

SER 1644 TRP 1645 0.2442

TRP 1645 GLU 1646 0.0744

GLU 1646 LYS 1647 0.0600

LYS 1647 VAL 1648 0.0956

VAL 1648 LEU 1649 0.0947

LEU 1649 LYS 1650 0.0521

LYS 1650 LYS 1651 0.0781

LYS 1651 THR 1652 0.0968

THR 1652 GLY 1653 0.0798

GLY 1653 PHE 1654 0.0419

PHE 1654 ASP 1655 0.0965

ASP 1655 GLY 1656 0.0231

GLY 1656 LEU 1657 0.0143

LEU 1657 ASP 1658 0.0968

ASP 1658 ILE 1659 0.0015

ILE 1659 GLU 1660 0.0444

GLU 1660 LEU 1661 0.1230

LEU 1661 ARG 1662 0.0390

ARG 1662 ASP 1663 0.0289

ASP 1663 CYS 1664 0.0976

CYS 1664 ASP 1665 0.1022

ASP 1665 SER 1666 0.0926

SER 1666 ASP 1667 0.0882

ASP 1667 GLU 1668 0.0332

GLU 1668 PHE 1669 0.1034

PHE 1669 TYR 1670 0.0393

TYR 1670 SER 1671 0.1066

SER 1671 PHE 1672 0.0733

PHE 1672 SER 1673 0.0258

SER 1673 VAL 1674 0.0923

VAL 1674 MET 1675 0.0090

MET 1675 MET 1676 0.0376

MET 1676 ALA 1677 0.1332

ALA 1677 THR 1678 0.0332

THR 1678 ALA 1679 0.0180

ALA 1679 SER 1680 0.0293

SER 1680 SER 1681 0.0495

SER 1681 THR 1682 0.0137

THR 1682 ILE 1683 0.0592

ILE 1683 ALA 1684 0.0198

ALA 1684 SER 1685 0.0546

SER 1685 SER 1686 0.0603

SER 1686 SER 1687 0.0401

SER 1687 MET 1688 0.0306

MET 1688 ALA 1689 0.0600

ALA 1689 PHE 1690 0.0105

PHE 1690 ALA 1691 0.0466

ALA 1691 ILE 1692 0.0153

ILE 1692 VAL 1693 -0.1366

VAL 1693 TYR 1694 0.0462

TYR 1694 GLY 1695 0.0509

GLY 1695 GLU 1696 0.0977

GLU 1696 VAL 1697 0.1078

VAL 1697 PRO 1698 0.0298

PRO 1698 LEU 1699 0.1080

LEU 1699 PRO 1700 0.1069

PRO 1700 ASP 1701 0.0072

ASP 1701 GLN 1702 0.1079

GLN 1702 PHE 1703 0.0920

PHE 1703 LEU 1704 0.0579

LEU 1704 ASP 1705 0.0493

ASP 1705 ASP 1706 0.0927

ASP 1706 MET 1707 0.1071

MET 1707 LYS 1708 0.0124

LYS 1708 THR 1709 0.0595

THR 1709 ALA 1710 0.0740

ALA 1710 ILE 1711 0.0944

ILE 1711 SER 1712 0.0105

SER 1712 SER 1713 0.1037

SER 1713 SER 1714 0.0955

SER 1714 ALA 1715 0.0744

ALA 1715 VAL 1716 0.0110

VAL 1716 SER 1717 0.0988

SER 1717 ASP 1718 0.0822

ASP 1718 PRO 1719 0.0377

PRO 1719 VAL 1720 0.1030

VAL 1720 VAL 1721 0.0316

VAL 1721 GLY 1722 0.0860

GLY 1722 HIS 1723 0.0327

HIS 1723 LEU 1724 0.0929

LEU 1724 ASP 1725 -0.0025

ASP 1725 SER 1726 0.0102

SER 1726 ILE 1727 0.0814

ILE 1727 ASP 1728 0.0541

ASP 1728 ALA 1729 0.0777

ALA 1729 THR 1730 0.0489

THR 1730 GLY 1731 0.0788

GLY 1731 LYS 1732 0.0743

LYS 1732 PHE 1733 0.0461

PHE 1733 CYS 1734 0.0440

CYS 1734 ILE 1735 0.0475

ILE 1735 PHE 1736 0.0459

PHE 1736 ILE 1737 0.0599

ILE 1737 GLU 1738 0.0339

GLU 1738 ASP 1739 0.0655

ASP 1739 PRO 1740 0.0213

PRO 1740 GLU 1741 0.0483

GLU 1741 THR 1742 0.0727

THR 1742 ASP 1743 0.0790

ASP 1743 ILE 1744 0.0443

ILE 1744 LEU 1745 0.0764

LEU 1745 SER 1746 0.0043

SER 1746 SER 1747 0.0823

SER 1747 PRO 1748 0.0052

PRO 1748 ASP 1749 0.0746

ASP 1749 GLU 1750 0.0485

GLU 1750 LYS 1751 0.0354

LYS 1751 SER 1752 0.0796

SER 1752 TYR 1753 0.0806

TYR 1753 ALA 1754 0.0198

ALA 1754 SER 1755 0.0665

SER 1755 ILE 1756 0.0689

ILE 1756 GLN 1757 0.1538

GLN 1757 LYS 1758 0.0138

LYS 1758 LEU 1759 0.0845

LEU 1759 VAL 1760 0.0787

VAL 1760 THR 1761 0.0525

THR 1761 ARG 1762 0.0321

ARG 1762 CYS 1763 0.0839

CYS 1763 LYS 1764 0.0676

LYS 1764 GLY 1765 0.0269

GLY 1765 LEU 1766 0.0305

LEU 1766 ILE 1767 0.0546

ILE 1767 TRP 1768 0.0287

TRP 1768 VAL 1769 0.0661

VAL 1769 SER 1770 0.0017

SER 1770 ARG 1771 0.0327

ARG 1771 GLY 1772 0.0212

GLY 1772 GLY 1773 0.0837

GLY 1773 ALA 1774 0.0817

ALA 1774 MET 1775 0.0595

MET 1775 HIS 1776 0.0200

HIS 1776 GLY 1777 0.0829

GLY 1777 THR 1778 0.0753

THR 1778 ARG 1779 0.0672

ARG 1779 PRO 1780 0.0836

PRO 1780 ASN 1781 0.0544

ASN 1781 SER 1782 0.0401

SER 1782 SER 1783 0.0840

SER 1783 LEU 1784 0.0765

LEU 1784 LYS 1785 0.0098

LYS 1785 THR 1786 0.0830

THR 1786 GLY 1787 0.0772

GLY 1787 LEU 1788 0.0381

LEU 1788 LEU 1789 0.0492

LEU 1789 ARG 1790 0.0633

ARG 1790 THR 1791 0.0702

THR 1791 LEU 1792 0.0166

LEU 1792 ARG 1793 0.0654

ARG 1793 LEU 1794 0.0707

LEU 1794 GLU 1795 0.0607

GLU 1795 TYR 1796 0.0248

TYR 1796 THR 1797 0.0699

THR 1797 GLU 1798 0.0157

GLU 1798 LYS 1799 0.0612

LYS 1799 ARG 1800 0.0592

ARG 1800 PHE 1801 0.0161

PHE 1801 ILE 1802 0.0582

ILE 1802 SER 1803 0.0149

SER 1803 LEU 1804 0.0713

LEU 1804 ASP 1805 0.0342

ASP 1805 LEU 1806 0.0944

LEU 1806 ASP 1807 0.0341

ASP 1807 SER 1808 0.0539

SER 1808 ALA 1809 0.0782

ALA 1809 ARG 1810 0.0318

ARG 1810 PRO 1811 0.0817

PRO 1811 GLN 1812 0.0699

GLN 1812 TRP 1813 0.0165

TRP 1813 ASN 1814 0.0933

ASN 1814 HIS 1815 0.0422

HIS 1815 ASP 1816 0.0745

ASP 1816 SER 1817 0.0945

SER 1817 ILE 1818 0.0029

ILE 1818 THR 1819 0.0939

THR 1819 THR 1820 0.0696

THR 1820 ILE 1821 0.1301

ILE 1821 ASN 1822 0.0140

ASN 1822 GLU 1823 0.0446

GLU 1823 VAL 1824 0.0485

VAL 1824 LEU 1825 0.0103

LEU 1825 CYS 1826 0.0415

CYS 1826 GLY 1827 0.0352

GLY 1827 ALA 1828 0.0494

ALA 1828 LEU 1829 0.0028

LEU 1829 ALA 1830 0.0521

ALA 1830 GLN 1831 0.0481

GLN 1831 ASN 1832 0.0196

ASN 1832 ALA 1833 0.0520

ALA 1833 ASP 1834 0.0365

ASP 1834 SER 1835 0.0096

SER 1835 SER 1836 0.0401

SER 1836 ILE 1837 -0.0530

ILE 1837 LYS 1838 0.0502

LYS 1838 ASP 1839 0.0139

ASP 1839 SER 1840 0.0476

SER 1840 GLU 1841 0.0061

GLU 1841 PHE 1842 0.0485

PHE 1842 ALA 1843 0.0153

ALA 1843 GLU 1844 0.0503

GLU 1844 GLN 1845 0.0175

GLN 1845 ASP 1846 0.0500

ASP 1846 GLY 1847 0.0027

GLY 1847 GLN 1848 0.0460

GLN 1848 LEU 1849 0.0407

LEU 1849 PHE 1850 0.0421

PHE 1850 VAL 1851 0.0448

VAL 1851 PRO 1852 0.0386

PRO 1852 ARG 1853 0.0779

ARG 1853 ILE 1854 0.0375

ILE 1854 SER 1855 0.0239

SER 1855 CYS 1856 0.0367

CYS 1856 ASP 1857 0.0180

ASP 1857 ILE 1858 0.0301

ILE 1858 ALA 1859 0.0150

ALA 1859 ARG 1860 0.0259

ARG 1860 ASN 1861 0.0248

ASN 1861 GLU 1862 0.0138

GLU 1862 ASP 1863 0.0349

ASP 1863 LEU 1864 0.0070

LEU 1864 SER 1865 0.0380

SER 1865 SER 1866 0.0037

SER 1866 ASP 1867 0.0354

ASP 1867 SER 1868 0.0331

SER 1868 ASN 1869 0.2900

ASN 1869 SER 1870 0.0264

SER 1870 PRO 1871 0.0518

PRO 1871 ALA 1872 0.0062

ALA 1872 GLN 1873 0.0410

GLN 1873 MET 1874 0.0277

MET 1874 GLU 1875 0.0133

GLU 1875 PRO 1876 0.0054

PRO 1876 PHE 1877 0.0470

PHE 1877 HIS 1878 0.0105

HIS 1878 GLN 1879 0.0515

GLN 1879 PRO 1880 0.0221

PRO 1880 GLY 1881 0.0504

GLY 1881 LYS 1882 0.0112

LYS 1882 LEU 1883 0.0507

LEU 1883 LEU 1884 0.0274

LEU 1884 GLN 1885 -0.0976

GLN 1885 MET 1886 0.0277

MET 1886 GLY 1887 0.0041

GLY 1887 ILE 1888 0.0118

ILE 1888 LYS 1889 0.0193

LYS 1889 THR 1890 0.0204

THR 1890 PRO 1891 0.0404

PRO 1891 GLY 1892 0.0376

GLY 1892 LEU 1893 0.0374

LEU 1893 ILE 1894 0.0037

ILE 1894 ASP 1895 0.0412

ASP 1895 THR 1896 0.0409

THR 1896 LEU 1897 0.0056

LEU 1897 GLN 1898 0.0343

GLN 1898 PHE 1899 0.0203

PHE 1899 SER 1900 0.0401

SER 1900 LYS 1901 -0.0014

LYS 1901 THR 1902 0.0486

THR 1902 ASP 1903 0.0331

ASP 1903 ALA 1904 0.0070

ALA 1904 THR 1905 0.0482

THR 1905 ASP 1906 0.0010

ASP 1906 ASN 1907 0.0505

ASN 1907 LEU 1908 0.0507

LEU 1908 PRO 1909 0.0507

PRO 1909 ASN 1910 0.0181

ASN 1910 ASP 1911 0.0475

ASP 1911 TYR 1912 0.0451

TYR 1912 ILE 1913 0.0445

ILE 1913 GLU 1914 0.0479

GLU 1914 ILE 1915 0.0513

ILE 1915 GLU 1916 0.0507

GLU 1916 PRO 1917 0.0076

PRO 1917 LYS 1918 0.0326

LYS 1918 ALA 1919 0.0237

ALA 1919 PHE 1920 0.0113

PHE 1920 GLY 1921 0.0317

GLY 1921 LEU 1922 0.0042

LEU 1922 ASN 1923 0.0258

ASN 1923 PHE 1924 0.0086

PHE 1924 ARG 1925 0.0353

ARG 1925 ASP 1926 0.0379

ASP 1926 VAL 1927 0.0236

VAL 1927 MET 1928 0.0215

MET 1928 VAL 1929 0.0385

VAL 1929 ALA 1930 0.0383

ALA 1930 MET 1931 0.0144

MET 1931 GLY 1932 0.0327

GLY 1932 GLN 1933 -0.0435

GLN 1933 LEU 1934 0.0289

LEU 1934 GLU 1935 0.0326

GLU 1935 GLU 1936 0.0069

GLU 1936 SER 1937 0.0337

SER 1937 ILE 1938 0.0013

ILE 1938 MET 1939 0.0222

MET 1939 GLY 1940 0.0011

GLY 1940 PHE 1941 0.0315

PHE 1941 GLU 1942 0.0031

GLU 1942 CYS 1943 0.0141

CYS 1943 ALA 1944 0.0009

ALA 1944 GLY 1945 0.0268

GLY 1945 VAL 1946 0.0197

VAL 1946 VAL 1947 0.0359

VAL 1947 ARG 1948 0.0360

ARG 1948 ARG 1949 0.1137

ARG 1949 VAL 1950 0.0455

VAL 1950 GLY 1951 0.0401

GLY 1951 PRO 1952 0.0253

PRO 1952 SER 1953 0.0429

SER 1953 SER 1954 0.0458

SER 1954 ALA 1955 0.0039

ALA 1955 GLY 1956 0.0433

GLY 1956 HIS 1957 0.0385

HIS 1957 ASN 1958 0.0291

ASN 1958 ILE 1959 0.0321

ILE 1959 LYS 1960 0.0363

LYS 1960 VAL 1961 0.0436

VAL 1961 GLY 1962 0.0453

GLY 1962 ASP 1963 0.0437

ASP 1963 ARG 1964 0.0328

ARG 1964 VAL 1965 -0.0227

VAL 1965 CYS 1966 0.0083

CYS 1966 ALA 1967 0.0237

ALA 1967 LEU 1968 0.0082

LEU 1968 LEU 1969 0.0353

LEU 1969 GLY 1970 0.0241

GLY 1970 GLY 1971 0.0368

GLY 1971 GLN 1972 0.0451

GLN 1972 TRP 1973 0.0471

TRP 1973 THR 1974 0.0290

THR 1974 ASN 1975 0.0160

ASN 1975 THR 1976 0.0410

THR 1976 VAL 1977 0.0462

VAL 1977 ARG 1978 0.0483

ARG 1978 VAL 1979 0.0488

VAL 1979 HIS 1980 0.0457

HIS 1980 TRP 1981 0.0579

TRP 1981 HIS 1982 0.0365

HIS 1982 SER 1983 0.0375

SER 1983 VAL 1984 0.0104

VAL 1984 ALA 1985 0.0237

ALA 1985 PRO 1986 0.0111

PRO 1986 ILE 1987 0.0437

ILE 1987 PRO 1988 0.0178

PRO 1988 GLN 1989 0.0287

GLN 1989 ALA 1990 0.0429

ALA 1990 MET 1991 0.0004

MET 1991 ASP 1992 0.0349

ASP 1992 TRP 1993 0.0218

TRP 1993 GLU 1994 0.0208

GLU 1994 THR 1995 0.0423

THR 1995 ALA 1996 0.0430

ALA 1996 ALA 1997 -0.0114

ALA 1997 SER 1998 0.0317

SER 1998 ILE 1999 0.0393

ILE 1999 PRO 2000 0.0348

PRO 2000 ILE 2001 0.0005

ILE 2001 VAL 2002 0.0403

VAL 2002 PHE 2003 0.0244

PHE 2003 VAL 2004 0.0366

VAL 2004 THR 2005 0.0043

THR 2005 ALA 2006 0.0372

ALA 2006 TYR 2007 0.0257

TYR 2007 ILE 2008 0.0232

ILE 2008 SER 2009 0.0193

SER 2009 LEU 2010 0.0320

LEU 2010 VAL 2011 0.0179

VAL 2011 LYS 2012 0.0359

LYS 2012 ILE 2013 0.0152

ILE 2013 ALA 2014 0.0308

ALA 2014 ARG 2015 0.0116

ARG 2015 MET 2016 0.0320

MET 2016 GLN 2017 0.0246

GLN 2017 ALA 2018 0.0243

ALA 2018 GLY 2019 0.0190

GLY 2019 GLU 2020 0.0125

GLU 2020 THR 2021 0.0232

THR 2021 VAL 2022 0.0317

VAL 2022 LEU 2023 0.0212

LEU 2023 ILE 2024 0.0279

ILE 2024 HIS 2025 0.0214

HIS 2025 ALA 2026 0.0282

ALA 2026 ALA 2027 0.0112

ALA 2027 SER 2028 0.0256

SER 2028 GLY 2029 0.0533

GLY 2029 GLY 2030 0.0184

GLY 2030 VAL 2031 0.0280

VAL 2031 GLY 2032 0.0322

GLY 2032 GLN 2033 0.0048

GLN 2033 ALA 2034 0.0305

ALA 2034 ALA 2035 0.0186

ALA 2035 ILE 2036 0.0325

ILE 2036 ILE 2037 0.0030

ILE 2037 LEU 2038 0.0339

LEU 2038 ALA 2039 0.0216

ALA 2039 LYS 2040 0.0174

LYS 2040 HIS 2041 0.0208

HIS 2041 VAL 2042 0.0216

VAL 2042 GLY 2043 0.0346

GLY 2043 ALA 2044 0.0025

ALA 2044 GLU 2045 -0.0195

GLU 2045 ILE 2046 0.0319

ILE 2046 PHE 2047 0.0095

PHE 2047 ALA 2048 0.0354

ALA 2048 THR 2049 0.0205

THR 2049 VAL 2050 0.0344

VAL 2050 GLY 2051 0.0253

GLY 2051 THR 2052 0.0306

THR 2052 ASP 2053 0.0274

ASP 2053 GLU 2054 0.0102

GLU 2054 LYS 2055 0.0357

LYS 2055 ARG 2056 0.0347

ARG 2056 ASP 2057 0.0136

ASP 2057 LEU 2058 0.0236

LEU 2058 LEU 2059 0.0340

LEU 2059 ILE 2060 0.0344

ILE 2060 LYS 2061 0.0092

LYS 2061 GLU 2062 0.0259

GLU 2062 TYR 2063 0.0302

TYR 2063 LYS 2064 0.0326

LYS 2064 ILE 2065 0.0059

ILE 2065 PRO 2066 0.0237

PRO 2066 ASP 2067 0.0181

ASP 2067 ASP 2068 0.0173

ASP 2068 HIS 2069 0.0314

HIS 2069 ILE 2070 0.0333

ILE 2070 PHE 2071 0.0063

PHE 2071 SER 2072 0.0270

SER 2072 SER 2073 0.0342

SER 2073 ARG 2074 0.0133

ARG 2074 ASN 2075 0.0187

ASN 2075 ALA 2076 0.0323

ALA 2076 LEU 2077 0.0035

LEU 2077 PHE 2078 0.0033

PHE 2078 ALA 2079 0.0229

ALA 2079 LYS 2080 0.0206

LYS 2080 SER 2081 0.0101

SER 2081 ILE 2082 0.0144

ILE 2082 ARG 2083 0.0179

ARG 2083 GLN 2084 0.0252

GLN 2084 ARG 2085 0.0005

ARG 2085 THR 2086 0.0245

THR 2086 ASN 2087 0.0172

ASN 2087 GLY 2088 0.0132

GLY 2088 LYS 2089 0.0146

LYS 2089 GLY 2090 0.0251

GLY 2090 VAL 2091 0.0089

VAL 2091 ASP 2092 0.0186

ASP 2092 VAL 2093 -0.0609

VAL 2093 VAL 2094 0.0144

VAL 2094 LEU 2095 0.0111

LEU 2095 ASN 2096 0.0088

ASN 2096 CYS 2097 0.0158

CYS 2097 LEU 2098 0.0054

LEU 2098 ALA 2099 0.0062

ALA 2099 GLY 2100 0.0003

GLY 2100 GLY 2101 0.0127

GLY 2101 LEU 2102 0.0036

LEU 2102 LEU 2103 0.0145

LEU 2103 GLN 2104 0.0053

GLN 2104 GLU 2105 0.0153

GLU 2105 SER 2106 0.0020

SER 2106 PHE 2107 0.0135

PHE 2107 ASP 2108 0.0094

ASP 2108 CYS 2109 -0.0129

CYS 2109 LEU 2110 0.0097

LEU 2110 ALA 2111 0.0094

ALA 2111 ASP 2112 0.0077

ASP 2112 PHE 2113 0.0096

PHE 2113 GLY 2114 0.0084

GLY 2114 ARG 2115 0.0098

ARG 2115 PHE 2116 0.0087

PHE 2116 ILE 2117 0.0082

ILE 2117 GLU 2118 0.0079

GLU 2118 ILE 2119 0.0071

ILE 2119 GLY 2120 0.0064

GLY 2120 LYS 2121 0.0055

LYS 2121 ARG 2122 0.0068

ARG 2122 ASP 2123 0.0062

ASP 2123 ILE 2124 0.0099

ILE 2124 GLU 2125 0.0171

GLU 2125 LEU 2126 0.0044

LEU 2126 ASN 2127 0.0044

ASN 2127 HIS 2128 0.0066

HIS 2128 CYS 2129 0.0045

CYS 2129 LEU 2130 0.0052

LEU 2130 ASN 2131 0.0057

ASN 2131 MET 2132 0.0060

MET 2132 GLY 2133 0.0066

GLY 2133 MET 2134 0.0009

MET 2134 PHE 2135 0.0062

PHE 2135 ALA 2136 0.0050

ALA 2136 ARG 2137 0.0010

ARG 2137 SER 2138 0.0064

SER 2138 ALA 2139 0.0042

ALA 2139 THR 2140 0.0060

THR 2140 PHE 2141 0.0434

PHE 2141 THR 2142 0.0152

THR 2142 ALA 2143 0.0181

ALA 2143 VAL 2144 0.0059

VAL 2144 ASP 2145 0.0182

ASP 2145 LEU 2146 0.0051

LEU 2146 ILE 2147 0.0145

ILE 2147 ALA 2148 0.0112

ALA 2148 ILE 2149 0.0075

ILE 2149 GLY 2150 0.0131

GLY 2150 ARG 2151 0.0082

ARG 2151 ASP 2152 0.0163

ASP 2152 ARG 2153 0.0079

ARG 2153 SER 2154 0.0059

SER 2154 TYR 2155 0.0126

TYR 2155 MET 2156 0.0181

MET 2156 PHE 2157 -0.0222

PHE 2157 ALA 2158 0.0123

ALA 2158 GLU 2159 0.0400

GLU 2159 ALA 2160 0.0366

ALA 2160 LEU 2161 0.0314

LEU 2161 PRO 2162 0.0055

PRO 2162 LYS 2163 0.0396

LYS 2163 ILE 2164 0.0366

ILE 2164 MET 2165 0.0135

MET 2165 THR 2166 0.0266

THR 2166 LEU 2167 0.0327

LEU 2167 LEU 2168 0.0393

LEU 2168 GLN 2169 0.0039

GLN 2169 GLU 2170 0.0390

GLU 2170 LYS 2171 0.0323

LYS 2171 ALA 2172 0.0252

ALA 2172 ILE 2173 0.0308

ILE 2173 ARG 2174 0.0474

ARG 2174 PRO 2175 0.0325

PRO 2175 VAL 2176 0.0118

VAL 2176 THR 2177 0.0482

THR 2177 PRO 2178 0.0444

PRO 2178 ILE 2179 0.0478

ILE 2179 SER 2180 0.0342

SER 2180 ILE 2181 0.0421

ILE 2181 TYR 2182 0.0330

TYR 2182 LYS 2183 0.0460

LYS 2183 ILE 2184 0.0342

ILE 2184 GLY 2185 0.0424

GLY 2185 ASP 2186 0.0410

ASP 2186 ILE 2187 0.0395

ILE 2187 GLU 2188 0.0080

GLU 2188 THR 2189 0.1035

THR 2189 ALA 2190 0.0333

ALA 2190 PHE 2191 0.0101

PHE 2191 ARG 2192 0.0291

ARG 2192 LEU 2193 0.0237

LEU 2193 MET 2194 0.0383

MET 2194 GLN 2195 0.0005

GLN 2195 ALA 2196 0.0389

ALA 2196 GLY 2197 0.0299

GLY 2197 LYS 2198 0.0235

LYS 2198 HIS 2199 0.0111

HIS 2199 MET 2200 0.0229

MET 2200 GLY 2201 0.0250

GLY 2201 LYS 2202 0.0389

LYS 2202 ILE 2203 0.0376

ILE 2203 VAL 2204 0.0229

VAL 2204 ILE 2205 0.1271

ILE 2205 THR 2206 0.0239

THR 2206 ALA 2207 0.0348

ALA 2207 PRO 2208 0.0297

PRO 2208 GLU 2209 0.0354

GLU 2209 ASP 2210 0.0159

ASP 2210 ALA 2211 0.0232

ALA 2211 MET 2212 0.0042

MET 2212 VAL 2213 0.0246

VAL 2213 PRO 2214 0.0039

PRO 2214 VAL 2215 0.0354

VAL 2215 ILE 2216 0.0175

ILE 2216 THR 2217 0.0347

THR 2217 ARG 2218 0.0320

ARG 2218 PRO 2219 0.0318

PRO 2219 PRO 2220 0.0229

PRO 2220 LYS 2221 0.2719

LYS 2221 LEU 2222 0.0671

LEU 2222 GLN 2223 0.0051

GLN 2223 LEU 2224 0.0659

LEU 2224 ARG 2225 0.0101

ARG 2225 PRO 2226 0.0545

PRO 2226 ASP 2227 0.0482

ASP 2227 ALA 2228 0.0264

ALA 2228 SER 2229 0.0372

SER 2229 TYR 2230 0.0026

TYR 2230 LEU 2231 0.0452

LEU 2231 ILE 2232 0.0121

ILE 2232 VAL 2233 0.0432

VAL 2233 GLY 2234 0.0412

GLY 2234 GLY 2235 0.0423

GLY 2235 LEU 2236 0.0601

LEU 2236 GLY 2237 0.0509

GLY 2237 GLY 2238 0.0431

GLY 2238 ILE 2239 0.0500

ILE 2239 GLY 2240 0.0116

GLY 2240 ARG 2241 0.0465

ARG 2241 SER 2242 0.0469

SER 2242 LEU 2243 0.0382

LEU 2243 CYS 2244 0.0182

CYS 2244 LYS 2245 0.0510

LYS 2245 ASN 2246 0.0498

ASN 2246 PHE 2247 0.0241

PHE 2247 VAL 2248 0.0299

VAL 2248 GLU 2249 0.0470

GLU 2249 ASN 2250 0.0507

ASN 2250 GLY 2251 0.0061

GLY 2251 ALA 2252 0.0511

ALA 2252 ARG 2253 -0.0089

ARG 2253 SER 2254 0.0698

SER 2254 LEU 2255 0.0146

LEU 2255 VAL 2256 0.0667

VAL 2256 LEU 2257 0.0243

LEU 2257 LEU 2258 0.0590

LEU 2258 SER 2259 0.0431

SER 2259 ARG 2260 0.0645

ARG 2260 ASN 2261 0.0698

ASN 2261 ALA 2262 0.0216

ALA 2262 ASN 2263 0.0706

ASN 2263 VAL 2264 0.0451

VAL 2264 SER 2265 0.0267

SER 2265 GLN 2266 0.0645

GLN 2266 GLN 2267 0.0279

GLN 2267 SER 2268 0.0568

SER 2268 GLY 2269 -0.0819

GLY 2269 GLU 2270 0.0588

GLU 2270 PHE 2271 0.0573

PHE 2271 LEU 2272 0.0210

LEU 2272 ASP 2273 0.0415

ASP 2273 GLU 2274 0.0471

GLU 2274 LEU 2275 0.0593

LEU 2275 ARG 2276 0.0062

ARG 2276 SER 2277 0.0612

SER 2277 THR 2278 0.0609

THR 2278 GLY 2279 0.0225

GLY 2279 CYS 2280 0.0436

CYS 2280 ILE 2281 0.0556

ILE 2281 VAL 2282 0.0238

VAL 2282 GLY 2283 0.0616

GLY 2283 VAL 2284 0.0277

VAL 2284 VAL 2285 0.3182

VAL 2285 ASP 2286 0.0374

ASP 2286 CYS 2287 0.0674

CYS 2287 ASP 2288 0.0134

ASP 2288 ILE 2289 0.0786

ILE 2289 SER 2290 0.0356

SER 2290 SER 2291 0.0486

SER 2291 LYS 2292 0.0525

LYS 2292 THR 2293 0.0459

THR 2293 GLN 2294 0.0784

GLN 2294 VAL 2295 0.0777

VAL 2295 GLU 2296 0.0396

GLU 2296 ALA 2297 0.0628

ALA 2297 THR 2298 0.0779

THR 2298 MET 2299 0.0686

MET 2299 LEU 2300 0.0322

LEU 2300 ARG 2301 0.1384

ARG 2301 LEU 2302 0.0757

LEU 2302 LYS 2303 0.0440

LYS 2303 LYS 2304 0.0444

LYS 2304 ASP 2305 0.0716

ASP 2305 MET 2306 0.0695

MET 2306 LEU 2307 0.0720

LEU 2307 PRO 2308 0.0680

PRO 2308 ILE 2309 0.0011

ILE 2309 ARG 2310 0.0730

ARG 2310 GLY 2311 0.0063

GLY 2311 ILE 2312 0.0271

ILE 2312 VAL 2313 0.0213

VAL 2313 HIS 2314 0.0422

HIS 2314 ALA 2315 0.0484

ALA 2315 GLY 2316 0.0724

GLY 2316 MET 2317 -0.0831

MET 2317 VAL 2318 0.0460

VAL 2318 LEU 2319 0.0181

LEU 2319 GLN 2320 0.0342

GLN 2320 ASP 2321 0.0336

ASP 2321 SER 2322 0.0172

SER 2322 VAL 2323 0.0344

VAL 2323 PHE 2324 0.0854

PHE 2324 GLU 2325 0.0271

GLU 2325 ARG 2326 0.0723

ARG 2326 MET 2327 0.0087

MET 2327 SER 2328 0.0789

SER 2328 LEU 2329 0.0588

LEU 2329 ASP 2330 0.0438

ASP 2330 ASP 2331 0.0850

ASP 2331 TYR 2332 0.0859

TYR 2332 ASN 2333 -0.0327

ASN 2333 THR 2334 0.0694

THR 2334 ALA 2335 0.0794

ALA 2335 ILE 2336 0.0742

ILE 2336 ARG 2337 0.0295

ARG 2337 PRO 2338 0.0483

PRO 2338 LYS 2339 0.0747

LYS 2339 VAL 2340 0.0783

VAL 2340 GLN 2341 0.0545

GLN 2341 GLY 2342 0.0478

GLY 2342 SER 2343 0.0783

SER 2343 TRP 2344 0.0792

TRP 2344 ASN 2345 0.0470

ASN 2345 LEU 2346 0.0593

LEU 2346 HIS 2347 0.0796

HIS 2347 SER 2348 0.0721

SER 2348 GLY 2349 0.0786

GLY 2349 LEU 2350 0.0699

LEU 2350 SER 2351 0.0805

SER 2351 ASP 2352 0.0019

ASP 2352 CYS 2353 0.0816

CYS 2353 ASP 2354 0.0792

ASP 2354 LEU 2355 0.0420

LEU 2355 ASP 2356 0.0814

ASP 2356 PHE 2357 0.0060

PHE 2357 PHE 2358 0.0400

PHE 2358 ILE 2359 0.0310

ILE 2359 MET 2360 0.0243

MET 2360 LEU 2361 0.0503

LEU 2361 SER 2362 0.0251

SER 2362 SER 2363 0.0179

SER 2363 LEU 2364 0.0450

LEU 2364 ALA 2365 0.1332

ALA 2365 GLY 2366 0.0808

GLY 2366 VAL 2367 0.0819

VAL 2367 SER 2368 0.0384

SER 2368 GLY 2369 0.0695

GLY 2369 SER 2370 0.0822

SER 2370 ALA 2371 0.0270

ALA 2371 SER 2372 0.0821

SER 2372 GLN 2373 0.0152

GLN 2373 ALA 2374 0.0814

ALA 2374 ASN 2375 0.0363

ASN 2375 TYR 2376 0.0497

TYR 2376 THR 2377 0.0777

THR 2377 ALA 2378 0.0842

ALA 2378 GLY 2379 0.0133

GLY 2379 GLY 2380 0.0811

GLY 2380 ALA 2381 0.0433

ALA 2381 TYR 2382 0.0461

TYR 2382 GLN 2383 0.0316

GLN 2383 ASP 2384 0.0717

ASP 2384 ALA 2385 0.0758

ALA 2385 LEU 2386 0.0228

LEU 2386 ALA 2387 0.0615

ALA 2387 LYS 2388 0.0707

LYS 2388 TYR 2389 0.0697

TYR 2389 ARG 2390 0.0150

ARG 2390 ARG 2391 0.0748

ARG 2391 ALA 2392 0.0706

ALA 2392 GLN 2393 0.0372

GLN 2393 GLY 2394 0.0457

GLY 2394 LEU 2395 0.0759

LEU 2395 SER 2396 0.0751

SER 2396 ALA 2397 -0.0018

ALA 2397 VAL 2398 0.0344

VAL 2398 SER 2399 0.0127

SER 2399 ILE 2400 0.0538

ILE 2400 ASP 2401 0.0019

ASP 2401 LEU 2402 0.0593

LEU 2402 GLY 2403 0.0245

GLY 2403 MET 2404 0.0576

MET 2404 VAL 2405 0.0219

VAL 2405 GLN 2406 0.0558

GLN 2406 SER 2407 0.0236

SER 2407 VAL 2408 0.0516

VAL 2408 GLY 2409 0.0548

GLY 2409 TYR 2410 0.0145

TYR 2410 VAL 2411 0.0394

VAL 2411 ALA 2412 0.0456

ALA 2412 GLU 2413 0.1078

GLU 2413 THR 2414 0.0038

THR 2414 LYS 2415 0.0397

LYS 2415 GLY 2416 0.0352

GLY 2416 VAL 2417 0.0614

VAL 2417 ALA 2418 0.0633

ALA 2418 GLU 2419 0.0181

GLU 2419 ARG 2420 0.0575

ARG 2420 LEU 2421 0.0419

LEU 2421 VAL 2422 0.0719

VAL 2422 ARG 2423 0.0007

ARG 2423 MET 2424 0.0711

MET 2424 GLY 2425 0.0524

GLY 2425 TYR 2426 0.0116

TYR 2426 SER 2427 0.0398

SER 2427 PRO 2428 0.0443

PRO 2428 ILE 2429 0.0540

ILE 2429 SER 2430 0.0292

SER 2430 GLU 2431 0.0118

GLU 2431 MET 2432 0.0364

MET 2432 GLU 2433 0.0359

GLU 2433 VAL 2434 0.0432

VAL 2434 LEU 2435 0.0042

LEU 2435 LYS 2436 0.0456

LYS 2436 ILE 2437 0.0389

ILE 2437 VAL 2438 0.0234

VAL 2438 GLU 2439 0.0231

GLU 2439 HIS 2440 0.0404

HIS 2440 ALA 2441 0.0457

ALA 2441 ILE 2442 0.0027

ILE 2442 THR 2443 0.0422

THR 2443 ASN 2444 0.0300

ASN 2444 PRO 2445 0.0210

PRO 2445 PRO 2446 0.0281

PRO 2446 PRO 2447 0.0404

PRO 2447 GLU 2448 0.0279

GLU 2448 ALA 2449 0.0432

ALA 2449 SER 2450 0.0092

SER 2450 SER 2451 0.0486

SER 2451 ALA 2452 0.0470

ALA 2452 GLN 2453 0.0147

GLN 2453 ILE 2454 0.0500

ILE 2454 ILE 2455 0.0055

ILE 2455 THR 2456 0.0500

THR 2456 GLY 2457 0.0250

GLY 2457 ILE 2458 0.0239

ILE 2458 SER 2459 0.0383

SER 2459 THR 2460 0.0511

THR 2460 LYS 2461 -0.0290

LYS 2461 PRO 2462 0.0154

PRO 2462 GLY 2463 0.0208

GLY 2463 ARG 2464 0.0055

ARG 2464 HIS 2465 0.0348

HIS 2465 TRP 2466 0.0361

TRP 2466 THR 2467 0.0032

THR 2467 GLU 2468 0.0357

GLU 2468 SER 2469 0.0292

SER 2469 SER 2470 0.0218

SER 2470 TRP 2471 0.0180

TRP 2471 LEU 2472 0.0285

LEU 2472 GLN 2473 0.0117

GLN 2473 ASP 2474 0.0354

ASP 2474 ALA 2475 0.0341

ALA 2475 ARG 2476 0.0089

ARG 2476 PHE 2477 0.1351

PHE 2477 ALA 2478 0.0241

ALA 2478 THR 2479 0.0047

THR 2479 LEU 2480 0.0227

LEU 2480 ARG 2481 0.0133

ARG 2481 GLU 2482 0.0259

GLU 2482 ARG 2483 0.0012

ARG 2483 ALA 2484 0.0251

ALA 2484 ARG 2485 0.0192

ARG 2485 ASP 2486 0.0121

ASP 2486 VAL 2487 0.0174

VAL 2487 LYS 2488 0.0140

LYS 2488 GLU 2489 0.0264

GLU 2489 LEU 2490 0.0008

LEU 2490 SER 2491 0.0268

SER 2491 ASN 2492 0.0171

ASN 2492 SER 2493 0.0486

SER 2493 GLN 2494 0.0013

GLN 2494 ASN 989 -0.2594

ASN 989 LYS 990 0.0068

LYS 990 ALA 991 0.0079

ALA 991 HIS 992 0.0066

HIS 992 ARG 993 0.0031

ARG 993 GLN 994 0.0077

GLN 994 ARG 995 0.0076

ARG 995 VAL 996 0.0050

VAL 996 HIS 997 0.0076

HIS 997 PRO 998 0.0070

PRO 998 PRO 999 0.0060

PRO 999 HIS 1000 0.0075

HIS 1000 ASP 1001 0.0074

ASP 1001 LEU 1002 0.0040

LEU 1002 LEU 1003 0.0043

LEU 1003 GLY 1004 0.0076

GLY 1004 SER 1005 0.0495

SER 1005 LEU 1006 0.0029

LEU 1006 ILE 1007 0.0004

ILE 1007 VAL 1008 0.0032

VAL 1008 GLY 1009 0.0013

GLY 1009 ARG 1010 0.0035

ARG 1010 ASP 1011 0.0035

ASP 1011 LEU 1012 0.0002

LEU 1012 ARG 1013 0.0031

ARG 1013 GLU 1014 0.0031

GLU 1014 PRO 1015 0.0022

PRO 1015 THR 1016 0.0034

THR 1016 TRP 1017 0.0019

TRP 1017 ARG 1018 0.0032

ARG 1018 HIS 1019 0.0021

HIS 1019 PHE 1020 0.0033

PHE 1020 ILE 1021 0.0526

ILE 1021 ARG 1022 0.0045

ARG 1022 VAL 1023 0.0039

VAL 1023 GLN 1024 0.0059

GLN 1024 ASP 1025 0.0091

ASP 1025 ILE 1026 0.0100

ILE 1026 PRO 1027 0.0051

PRO 1027 TRP 1028 0.0101

TRP 1028 ILE 1029 0.0024

ILE 1029 ARG 1030 0.0069

ARG 1030 ASP 1031 0.0092

ASP 1031 HIS 1032 0.0014

HIS 1032 VAL 1033 0.0090

VAL 1033 VAL 1034 0.0045

VAL 1034 GLN 1035 0.0096

GLN 1035 SER 1036 0.0063

SER 1036 ALA 1037 0.0781

ALA 1037 LEU 1038 0.0051

LEU 1038 VAL 1039 0.0023

VAL 1039 TYR 1040 0.0053

TYR 1040 PRO 1041 0.0054

PRO 1041 GLY 1042 0.0010

GLY 1042 ALA 1043 0.0045

ALA 1043 GLY 1044 0.0055

GLY 1044 PHE 1045 0.0004

PHE 1045 ILE 1046 0.0054

ILE 1046 CYS 1047 0.0022

CYS 1047 MET 1048 0.0046

MET 1048 ALA 1049 0.0015

ALA 1049 MET 1050 0.0038

MET 1050 GLU 1051 0.0041

GLU 1051 ALA 1052 0.0015

ALA 1052 MET 1053 0.0088

MET 1053 VAL 1054 -0.0000

VAL 1054 GLN 1055 0.0061

GLN 1055 LEU 1056 0.0032

LEU 1056 HIS 1057 0.0042

HIS 1057 GLU 1058 0.0019

GLU 1058 LEU 1059 0.0044

LEU 1059 ARG 1060 0.0053

ARG 1060 ASP 1061 0.0035

ASP 1061 SER 1062 0.0015

SER 1062 GLN 1063 0.0060

GLN 1063 SER 1064 0.0050

SER 1064 ARG 1065 0.0036

ARG 1065 LYS 1066 0.0056

LYS 1066 VAL 1067 0.0031

VAL 1067 ALA 1068 0.0057

ALA 1068 GLY 1069 0.0144

GLY 1069 TYR 1070 0.0034

TYR 1070 ARG 1071 0.0014

ARG 1071 LEU 1072 0.0038

LEU 1072 ALA 1073 0.0015

ALA 1073 GLU 1074 0.0033

GLU 1074 VAL 1075 0.0012

VAL 1075 ASP 1076 0.0040

ASP 1076 ILE 1077 0.0017

ILE 1077 LEU 1078 0.0029

LEU 1078 ARG 1079 0.0021

ARG 1079 ALA 1080 -0.0001

ALA 1080 MET 1081 0.0033

MET 1081 LEU 1082 0.0024

LEU 1082 ILE 1083 0.0017

ILE 1083 PRO 1084 0.0036

PRO 1084 ASP 1085 0.0298

ASP 1085 THR 1086 0.0031

THR 1086 SER 1087 0.0027

SER 1087 GLU 1088 0.0017

GLU 1088 GLY 1089 0.0032

GLY 1089 LEU 1090 0.0022

LEU 1090 GLU 1091 0.0031

GLU 1091 ALA 1092 0.0030

ALA 1092 HIS 1093 0.0033

HIS 1093 ILE 1094 0.0030

ILE 1094 SER 1095 0.0023

SER 1095 LEU 1096 0.0030

LEU 1096 ARG 1097 0.0017

ARG 1097 PRO 1098 0.0032

PRO 1098 CYS 1099 0.0028

CYS 1099 SER 1100 0.0016

SER 1100 THR 1101 0.0376

THR 1101 LYS 1102 0.0007

LYS 1102 LEU 1103 0.0018

LEU 1103 LEU 1104 0.0016

LEU 1104 LEU 1105 0.0009

LEU 1105 THR 1106 0.0003

THR 1106 ASN 1107 0.0018

ASN 1107 GLU 1108 0.0019

GLU 1108 TRP 1109 0.0014

TRP 1109 TYR 1110 0.0017

TYR 1110 ASP 1111 0.0003

ASP 1111 PHE 1112 0.0020

PHE 1112 CYS 1113 0.0009

CYS 1113 VAL 1114 0.0023

VAL 1114 SER 1115 0.0011

SER 1115 SER 1116 0.0021

SER 1116 VAL 1117 -0.0062

VAL 1117 GLY 1118 0.0017

GLY 1118 ASP 1119 0.0017

ASP 1119 ASP 1120 0.0001

ASP 1120 ASP 1121 0.0017

ASP 1121 LYS 1122 0.0014

LYS 1122 PHE 1123 0.0014

PHE 1123 VAL 1124 0.0017

VAL 1124 ASP 1125 0.0017

ASP 1125 HIS 1126 0.0005

HIS 1126 CYS 1127 0.0015

CYS 1127 ARG 1128 0.0013

ARG 1128 GLY 1129 0.0016

GLY 1129 ARG 1130 0.0019

ARG 1130 ILE 1131 0.0007

ILE 1131 THR 1132 0.0018

THR 1132 ILE 1133 -0.0425

ILE 1133 GLU 1134 0.0087

GLU 1134 PHE 1135 0.0190

PHE 1135 ASP 1136 0.0165

ASP 1136 THR 1137 0.0116

THR 1137 SER 1138 0.0195

SER 1138 GLY 1139 0.0003

GLY 1139 SER 1140 0.0167

SER 1140 ALA 1141 0.0162

ALA 1141 ASP 1142 0.0197

ASP 1142 THR 1143 0.0137

THR 1143 PRO 1144 0.0194

PRO 1144 ARG 1145 0.0159

ARG 1145 THR 1146 0.0099

THR 1146 SER 1147 0.0185

SER 1147 LEU 1148 0.0197

LEU 1148 ARG 1149 -0.0469

ARG 1149 GLU 1150 0.0506

GLU 1150 ARG 1151 0.0526

ARG 1151 SER 1152 0.0331

SER 1152 ARG 1153 0.0681

ARG 1153 SER 1154 0.0633

SER 1154 THR 1155 0.0611

THR 1155 GLY 1156 0.0047

GLY 1156 LEU 1157 0.0195

LEU 1157 MET 1158 0.0738

MET 1158 ARG 1159 0.0032

ARG 1159 SER 1160 0.0696

SER 1160 VAL 1161 0.0533

VAL 1161 ASP 1162 0.0514

ASP 1162 PRO 1163 0.0794

PRO 1163 SER 1164 0.0034

SER 1164 ASN 1165 0.0474

ASN 1165 LEU 1166 0.0001

LEU 1166 TYR 1167 0.0104

TYR 1167 SER 1168 0.0041

SER 1168 PHE 1169 0.0083

PHE 1169 LEU 1170 0.0020

LEU 1170 ARG 1171 0.0084

ARG 1171 ALA 1172 0.0084

ALA 1172 GLN 1173 0.0020

GLN 1173 GLY 1174 0.0095

GLY 1174 ILE 1175 0.0085

ILE 1175 TYR 1176 0.0083

TYR 1176 HIS 1177 0.0099

HIS 1177 GLY 1178 0.0081

GLY 1178 PRO 1179 0.0094

PRO 1179 ILE 1180 0.0021

ILE 1180 PHE 1181 -0.0774

PHE 1181 GLN 1182 0.0140

GLN 1182 ASN 1183 0.0101

ASN 1183 LEU 1184 0.0171

LEU 1184 LYS 1185 0.0160

LYS 1185 THR 1186 0.0160

THR 1186 ILE 1187 0.0154

ILE 1187 SER 1188 0.0143

SER 1188 SER 1189 0.0161

SER 1189 ARG 1190 0.0148

ARG 1190 LYS 1191 0.0163

LYS 1191 ASP 1192 0.0058

ASP 1192 HIS 1193 0.0176

HIS 1193 SER 1194 0.0115

SER 1194 GLU 1195 0.0175

GLU 1195 SER 1196 0.0114

SER 1196 SER 1197 0.1031

SER 1197 PHE 1198 0.0103

PHE 1198 VAL 1199 0.0093

VAL 1199 VAL 1200 0.0108

VAL 1200 ALA 1201 0.0066

ALA 1201 ASN 1202 0.0078

ASN 1202 THR 1203 0.0094

THR 1203 ALA 1204 0.0101

ALA 1204 SER 1205 0.0013

SER 1205 VAL 1206 0.0112

VAL 1206 MET 1207 0.0085

MET 1207 PRO 1208 0.0090

PRO 1208 ASN 1209 0.0098

ASN 1209 GLY 1210 0.0095

GLY 1210 PHE 1211 0.0029

PHE 1211 GLN 1212 0.0028

GLN 1212 SER 1213 -0.0049

SER 1213 PRO 1214 0.0098

PRO 1214 HIS 1215 0.0079

HIS 1215 VAL 1216 0.0079

VAL 1216 ILE 1217 0.0094

ILE 1217 HIS 1218 0.0064

HIS 1218 PRO 1219 0.0112

PRO 1219 THR 1220 0.0033

THR 1220 THR 1221 0.0109

THR 1221 LEU 1222 0.0015

LEU 1222 ASP 1223 0.0102

ASP 1223 SER 1224 0.0073

SER 1224 ILE 1225 0.0037

ILE 1225 PHE 1226 0.0101

PHE 1226 GLN 1227 0.0032

GLN 1227 GLY 1228 0.0116

GLY 1228 ALA 1229 0.1041

ALA 1229 TYR 1230 0.0015

TYR 1230 THR 1231 0.0070

THR 1231 ALA 1232 0.0050

ALA 1232 LEU 1233 0.0062

LEU 1233 PRO 1234 0.0040

PRO 1234 GLY 1235 0.0021

GLY 1235 ALA 1236 0.0053

ALA 1236 GLY 1237 0.0078

GLY 1237 LEU 1238 0.0001

LEU 1238 ASP 1239 0.0077

ASP 1239 GLN 1240 0.0049

GLN 1240 ASN 1241 0.0072

ASN 1241 THR 1242 0.0052

THR 1242 ALA 1243 0.0066

ALA 1243 MET 1244 0.0010

MET 1244 ILE 1245 0.1666

ILE 1245 PRO 1246 0.0042

PRO 1246 ARG 1247 0.0016

ARG 1247 SER 1248 0.0040

SER 1248 ILE 1249 0.0069

ILE 1249 GLN 1250 0.0015

GLN 1250 GLU 1251 0.0066

GLU 1251 LEU 1252 0.0022

LEU 1252 TYR 1253 0.0068

TYR 1253 LEU 1254 0.0025

LEU 1254 SER 1255 0.0070

SER 1255 SER 1256 0.0061

SER 1256 ALA 1257 0.0047

ALA 1257 LEU 1258 0.0050

LEU 1258 THR 1259 0.0014

THR 1259 SER 1260 0.0054

SER 1260 ASP 1261 -0.0357

ASP 1261 VAL 1262 0.0009

VAL 1262 GLY 1263 0.0059

GLY 1263 GLN 1264 0.0034

GLN 1264 CYS 1265 0.0079

CYS 1265 LEU 1266 0.0047

LEU 1266 VAL 1267 0.0085

VAL 1267 SER 1268 0.0075

SER 1268 ASP 1269 0.0077

ASP 1269 THR 1270 0.0083

THR 1270 SER 1271 0.0073

SER 1271 LEU 1272 0.0080

LEU 1272 ILE 1273 0.0027

ILE 1273 ARG 1274 0.0069

ARG 1274 TYR 1275 0.0018

TYR 1275 ASP 1276 0.0081

ASP 1276 GLY 1277 -0.0363

GLY 1277 GLN 1278 0.0074

GLN 1278 SER 1279 0.0052

SER 1279 PHE 1280 0.0083

PHE 1280 THR 1281 0.0039

THR 1281 VAL 1282 0.0086

VAL 1282 ASN 1283 0.0065

ASN 1283 VAL 1284 0.0063

VAL 1284 ASP 1285 0.0081

ASP 1285 VAL 1286 0.0059

VAL 1286 SER 1287 0.0086

SER 1287 SER 1288 0.0060

SER 1288 LYS 1289 0.0039

LYS 1289 ALA 1290 0.0084

ALA 1290 ASP 1291 0.0009

ASP 1291 SER 1292 0.0087

SER 1292 GLU 1293 -0.0507

GLU 1293 HIS 1294 0.0068

HIS 1294 THR 1295 0.0031

THR 1295 PRO 1296 0.0080

PRO 1296 VAL 1297 0.0078

VAL 1297 LEU 1298 0.0079

LEU 1298 GLU 1299 0.0062

GLU 1299 ILE 1300 0.0080

ILE 1300 LYS 1301 0.0053

LYS 1301 GLY 1302 0.0076

GLY 1302 LEU 1303 0.0022

LEU 1303 ARG 1304 0.0076

ARG 1304 ASN 1305 0.0013

ASN 1305 GLN 1306 0.0079

GLN 1306 SER 1307 0.0029

SER 1307 VAL 1308 0.0072

VAL 1308 GLY 1309 0.4334

GLY 1309 GLN 1310 0.0163

GLN 1310 MET 1311 0.0101

MET 1311 ALA 1312 0.0129

ALA 1312 PRO 1313 0.0130

PRO 1313 GLN 1314 0.0088

GLN 1314 PRO 1315 0.0130

PRO 1315 GLY 1316 0.0091

GLY 1316 ASP 1317 0.0057

ASP 1317 SER 1318 0.0154

SER 1318 SER 1319 0.0006

SER 1319 ASN 1320 0.0159

ASN 1320 ASN 1321 0.0158

ASN 1321 ASP 1322 0.0160

ASP 1322 LEU 1323 0.0018

LEU 1323 CYS 1324 0.0148

CYS 1324 PHE 1325 0.4222

PHE 1325 LYS 1326 0.0164

LYS 1326 LEU 1327 0.0167

LEU 1327 ASP 1328 0.0179

ASP 1328 TRP 1329 0.0188

TRP 1329 ALA 1330 0.0189

ALA 1330 PRO 1331 0.0182

PRO 1331 ASP 1332 0.0013

ASP 1332 ILE 1333 0.0189

ILE 1333 SER 1334 0.0074

SER 1334 SER 1335 0.0129

SER 1335 VAL 1336 0.0050

VAL 1336 LYS 1337 0.0166

LYS 1337 GLN 1338 0.0174

GLN 1338 GLU 1339 0.0039

GLU 1339 ARG 1340 0.0177

ARG 1340 LEU 1341 0.4975

LEU 1341 LYS 1342 0.0466

LYS 1342 GLU 1343 0.0646

GLU 1343 LYS 1344 0.0610

LYS 1344 PHE 1345 0.0457

PHE 1345 GLY 1346 0.0581

GLY 1346 PHE 1347 0.0040

PHE 1347 PRO 1348 0.0570

PRO 1348 LEU 1349 0.0305

LEU 1349 ASP 1350 0.0125

ASP 1350 PRO 1351 0.0429

PRO 1351 THR 1352 0.0256

THR 1352 GLU 1353 0.0511

GLU 1353 ALA 1354 0.0607

ALA 1354 ASP 1355 0.0036

ASP 1355 ILE 1356 0.0621

ILE 1356 ILE 1357 -0.0770

ILE 1357 MET 1358 0.2177

MET 1358 GLY 1359 0.1989

GLY 1359 LEU 1360 0.1475

LEU 1360 ARG 1361 0.2773

ARG 1361 GLN 1362 0.0542

GLN 1362 ALA 1363 0.2975

ALA 1363 CYS 1364 0.0860

CYS 1364 ILE 1365 0.2817

ILE 1365 HIS 1366 0.1120

HIS 1366 PHE 1367 0.2374

PHE 1367 ILE 1368 0.1899

ILE 1368 HIS 1369 0.1778

HIS 1369 ARG 1370 0.2337

ARG 1370 SER 1371 0.1257

SER 1371 LEU 1372 0.2745

LEU 1372 GLN 1373 0.1474

GLN 1373 SER 1374 0.3335

SER 1374 LEU 1375 0.0477

LEU 1375 THR 1376 0.3336

THR 1376 ALA 1377 0.1599

ALA 1377 PRO 1378 0.3148

PRO 1378 ASP 1379 0.3329

ASP 1379 ARG 1380 0.2284

ARG 1380 ASP 1381 0.2116

ASP 1381 GLN 1382 0.3335

GLN 1382 LEU 1383 0.3257

LEU 1383 ASP 1384 0.1147

ASP 1384 TRP 1385 0.2045

TRP 1385 HIS 1386 0.3111

HIS 1386 GLN 1387 0.0333

GLN 1387 LYS 1388 0.3198

LYS 1388 ARG 1389 0.3749

ARG 1389 PHE 1390 0.1039

PHE 1390 TYR 1391 0.2681

TYR 1391 ASP 1392 0.2543

ASP 1392 TRP 1393 0.3129

TRP 1393 MET 1394 0.0264

MET 1394 VAL 1395 0.3228

VAL 1395 LEU 1396 0.2748

LEU 1396 GLN 1397 0.1956

GLN 1397 ILE 1398 0.1764

ILE 1398 GLN 1399 0.2661

GLN 1399 LEU 1400 0.3203

LEU 1400 ALA 1401 0.0261

ALA 1401 GLU 1402 0.3095

GLU 1402 GLU 1403 0.2334

GLU 1403 ASP 1404 0.2709

ASP 1404 ARG 1405 0.1934

ARG 1405 LEU 1406 0.3122

LEU 1406 ALA 1407 0.2143

ALA 1407 PRO 1408 0.2298

PRO 1408 ASN 1409 0.1910

ASN 1409 SER 1410 0.2779

SER 1410 SER 1411 0.2986

SER 1411 ALA 1412 0.0637

ALA 1412 TRP 1413 0.2994

TRP 1413 LEU 1414 0.3208

LEU 1414 GLN 1415 0.0225

GLN 1415 CYS 1416 0.2893

CYS 1416 SER 1417 0.1111

SER 1417 SER 1418 0.3197

SER 1418 SER 1419 0.2383

SER 1419 ASP 1420 0.2348

ASP 1420 GLU 1421 0.0842

GLU 1421 GLN 1422 0.2719

GLN 1422 LYS 1423 0.2884

LYS 1423 LEU 1424 0.0725

LEU 1424 LEU 1425 0.2496

LEU 1425 GLU 1426 0.2375

GLU 1426 ASN 1427 0.2808

ASN 1427 VAL 1428 0.0363

VAL 1428 ARG 1429 0.2938

ARG 1429 ALA 1430 0.2632

ALA 1430 SER 1431 0.2231

SER 1431 SER 1432 0.0598

SER 1432 VAL 1433 0.2110

VAL 1433 ASN 1434 0.2749

ASN 1434 GLY 1435 0.0389

GLY 1435 GLN 1436 0.2931

GLN 1436 MET 1437 0.1232

MET 1437 VAL 1438 0.2715

VAL 1438 VAL 1439 0.0526

VAL 1439 HIS 1440 0.2607

HIS 1440 VAL 1441 0.1620

VAL 1441 GLY 1442 0.2256

GLY 1442 LYS 1443 0.1253

LYS 1443 SER 1444 0.1967

SER 1444 MET 1445 0.2042

MET 1445 LEU 1446 0.2567

LEU 1446 ALA 1447 0.2824

ALA 1447 ILE 1448 0.0438

ILE 1448 LEU 1449 0.2746

LEU 1449 ARG 1450 0.2528

ARG 1450 HIS 1451 0.2054

HIS 1451 GLU 1452 0.1187

GLU 1452 ILE 1453 0.1270

ILE 1453 ALA 1454 0.0628

ALA 1454 PRO 1455 0.2513

PRO 1455 LEU 1456 0.1801

LEU 1456 GLU 1457 0.1893

GLU 1457 LEU 1458 0.0975

LEU 1458 MET 1459 0.2163

MET 1459 LEU 1460 0.2367

LEU 1460 GLN 1461 0.0380

GLN 1461 ASP 1462 0.2210

ASP 1462 LYS 1463 0.0629

LYS 1463 LEU 1464 0.2330

LEU 1464 LEU 1465 0.0387

LEU 1465 TYR 1466 0.2347

TYR 1466 ARG 1467 0.1210

ARG 1467 TYR 1468 0.2407

TYR 1468 TYR 1469 -0.1247

TYR 1469 THR 1470 0.0929

THR 1470 ASP 1471 0.0222

ASP 1471 ALA 1472 0.0885

ALA 1472 ILE 1473 0.0924

ILE 1473 LYS 1474 0.0299

LYS 1474 TRP 1475 0.0597

TRP 1475 ASP 1476 0.0917

ASP 1476 ARG 1477 0.0862

ARG 1477 SER 1478 0.0518

SER 1478 TYR 1479 0.0840

TYR 1479 GLN 1480 0.0930

GLN 1480 GLN 1481 0.0681

GLN 1481 ILE 1482 0.0645

ILE 1482 ASP 1483 0.0928

ASP 1483 GLN 1484 0.0827

GLN 1484 LEU 1485 0.0559

LEU 1485 VAL 1486 0.0155

VAL 1486 LYS 1487 0.0078

LYS 1487 LEU 1488 0.0099

LEU 1488 HIS 1489 0.0147

HIS 1489 ALA 1490 0.0152

ALA 1490 HIS 1491 0.0035

HIS 1491 LYS 1492 0.0144

LYS 1492 CYS 1493 0.0129

CYS 1493 PRO 1494 0.0151

PRO 1494 THR 1495 0.0149

THR 1495 ALA 1496 0.0068

ALA 1496 LYS 1497 0.0069

LYS 1497 ILE 1498 0.0060

ILE 1498 ILE 1499 0.0015

ILE 1499 GLU 1500 0.0062

GLU 1500 ILE 1501 -0.1317

ILE 1501 GLY 1502 0.0029

GLY 1502 ALA 1503 0.0282

ALA 1503 GLY 1504 0.0076

GLY 1504 THR 1505 0.0186

THR 1505 GLY 1506 0.0156

GLY 1506 GLY 1507 0.0242

GLY 1507 CYS 1508 0.0077

CYS 1508 THR 1509 0.0224

THR 1509 ARG 1510 0.0229

ARG 1510 ALA 1511 0.0277

ALA 1511 VAL 1512 0.0041

VAL 1512 LEU 1513 0.0294

LEU 1513 ASP 1514 0.0249

ASP 1514 ALA 1515 0.0162

ALA 1515 LEU 1516 0.0140

LEU 1516 SER 1517 0.1462

SER 1517 ASN 1518 0.0131

ASN 1518 GLN 1519 0.0079

GLN 1519 GLY 1520 0.0138

GLY 1520 ILE 1521 0.0017

ILE 1521 ALA 1522 0.0132

ALA 1522 ARG 1523 0.0056

ARG 1523 CYS 1524 0.0135

CYS 1524 ALA 1525 0.0111

ALA 1525 GLN 1526 0.0074

GLN 1526 TYR 1527 0.0052

TYR 1527 ASP 1528 0.0129

ASP 1528 PHE 1529 0.0009

PHE 1529 THR 1530 0.0137

THR 1530 ASP 1531 0.0064

ASP 1531 VAL 1532 0.0137

VAL 1532 SER 1533 0.1917

SER 1533 SER 1534 0.0222

SER 1534 GLY 1535 0.0007

GLY 1535 PHE 1536 0.0222

PHE 1536 PHE 1537 0.0087

PHE 1537 GLU 1538 0.0164

GLU 1538 ALA 1539 0.0156

ALA 1539 ALA 1540 0.0078

ALA 1540 GLN 1541 0.0170

GLN 1541 GLN 1542 0.0094

GLN 1542 LYS 1543 0.0224

LYS 1543 PHE 1544 0.0010

PHE 1544 ALA 1545 0.0215

ALA 1545 ALA 1546 0.0191

ALA 1546 PHE 1547 0.0108

PHE 1547 ASP 1548 0.0224

ASP 1548 ASP 1549 -0.2915

ASP 1549 VAL 1550 0.0246

VAL 1550 ILE 1551 0.0203

ILE 1551 ARG 1552 0.0322

ARG 1552 PHE 1553 0.0179

PHE 1553 GLN 1554 0.0293

GLN 1554 LYS 1555 0.0306

LYS 1555 LEU 1556 0.0186

LEU 1556 ASP 1557 0.0321

ASP 1557 ILE 1558 0.0135

ILE 1558 GLU 1559 0.0322

GLU 1559 LYS 1560 0.0308

LYS 1560 ASP 1561 0.0080

ASP 1561 ILE 1562 0.0322

ILE 1562 GLU 1563 0.0253

GLU 1563 MET 1564 0.0171

MET 1564 GLN 1565 0.0606

GLN 1565 GLY 1566 0.0281

GLY 1566 PHE 1567 0.0330

PHE 1567 GLU 1568 0.0126

GLU 1568 CYS 1569 0.0308

CYS 1569 GLY 1570 0.0332

GLY 1570 SER 1571 0.0272

SER 1571 TYR 1572 0.0075

TYR 1572 ASP 1573 0.0317

ASP 1573 LEU 1574 0.0064

LEU 1574 VAL 1575 0.0290

VAL 1575 ILE 1576 0.0007

ILE 1576 ALA 1577 0.0277

ALA 1577 SER 1578 0.0012

SER 1578 GLN 1579 0.0281

GLN 1579 VAL 1580 0.0191

VAL 1580 LEU 1581 -0.0161

LEU 1581 HIS 1582 0.0660

HIS 1582 ALA 1583 0.0774

ALA 1583 THR 1584 0.0006

THR 1584 GLY 1585 0.0496

GLY 1585 LYS 1586 0.0535

LYS 1586 MET 1587 0.0705

MET 1587 GLU 1588 0.0172

GLU 1588 HIS 1589 0.0704

HIS 1589 THR 1590 0.0261

THR 1590 MET 1591 0.0773

MET 1591 ALA 1592 0.0040

ALA 1592 ASN 1593 0.0728

ASN 1593 VAL 1594 0.0359

VAL 1594 ARG 1595 0.0450

ARG 1595 LYS 1596 0.0535

LYS 1596 LEU 1597 0.1600

LEU 1597 LEU 1598 0.0718

LEU 1598 LYS 1599 0.0341

LYS 1599 PRO 1600 0.0590

PRO 1600 GLY 1601 0.0416

GLY 1601 GLY 1602 0.0346

GLY 1602 LYS 1603 0.0128

LYS 1603 LEU 1604 0.0511

LEU 1604 LEU 1605 0.0021

LEU 1605 LEU 1606 0.0559

LEU 1606 VAL 1607 0.0030

VAL 1607 GLU 1608 0.0721

GLU 1608 THR 1609 0.0449

THR 1609 THR 1610 0.0603

THR 1610 ARG 1611 0.0284

ARG 1611 ASP 1612 0.0492

ASP 1612 GLU 1613 0.1415

GLU 1613 MET 1614 0.1916

MET 1614 ASP 1615 0.2340

ASP 1615 LEU 1616 0.0485

LEU 1616 GLN 1617 0.2360

GLN 1617 LEU 1618 0.1106

LEU 1618 VAL 1619 0.2567

VAL 1619 PHE 1620 0.0069

PHE 1620 GLY 1621 0.2536

GLY 1621 LEU 1622 0.2381

LEU 1622 LEU 1623 0.1036

LEU 1623 PRO 1624 0.0758

PRO 1624 GLY 1625 0.2094

GLY 1625 TRP 1626 0.2144

TRP 1626 TRP 1627 0.2174

TRP 1627 LEU 1628 0.0390

LEU 1628 SER 1629 0.4436

SER 1629 SER 1630 0.0971

SER 1630 GLU 1631 0.1689

GLU 1631 GLU 1632 0.1392

GLU 1632 GLU 1633 0.1198

GLU 1633 ARG 1634 0.1559

ARG 1634 GLN 1635 0.1642

GLN 1635 MET 1636 0.0111

MET 1636 SER 1637 0.1696

SER 1637 PRO 1638 0.1213

PRO 1638 SER 1639 0.1654

SER 1639 LEU 1640 0.1299

LEU 1640 SER 1641 0.1502

SER 1641 THR 1642 0.1605

THR 1642 ASN 1643 0.1211

ASN 1643 SER 1644 0.1363

SER 1644 TRP 1645 0.5422

TRP 1645 GLU 1646 0.0741

GLU 1646 LYS 1647 0.0596

LYS 1647 VAL 1648 0.0952

VAL 1648 LEU 1649 0.0942

LEU 1649 LYS 1650 0.0520

LYS 1650 LYS 1651 0.0776

LYS 1651 THR 1652 0.0963

THR 1652 GLY 1653 0.0793

GLY 1653 PHE 1654 0.0419

PHE 1654 ASP 1655 0.0961

ASP 1655 GLY 1656 0.0232

GLY 1656 LEU 1657 0.0141

LEU 1657 ASP 1658 0.0964

ASP 1658 ILE 1659 0.0014

ILE 1659 GLU 1660 0.0445

GLU 1660 LEU 1661 -0.1115

LEU 1661 ARG 1662 0.0391

ARG 1662 ASP 1663 0.0286

ASP 1663 CYS 1664 0.0974

CYS 1664 ASP 1665 0.1017

ASP 1665 SER 1666 0.0923

SER 1666 ASP 1667 0.0878

ASP 1667 GLU 1668 0.0333

GLU 1668 PHE 1669 0.1029

PHE 1669 TYR 1670 0.0393

TYR 1670 SER 1671 0.1061

SER 1671 PHE 1672 0.0732

PHE 1672 SER 1673 0.0259

SER 1673 VAL 1674 0.0917

VAL 1674 MET 1675 0.0090

MET 1675 MET 1676 0.0377

MET 1676 ALA 1677 0.2611

ALA 1677 THR 1678 0.0335

THR 1678 ALA 1679 0.0178

ALA 1679 SER 1680 0.0296

SER 1680 SER 1681 0.0498

SER 1681 THR 1682 0.0134

THR 1682 ILE 1683 0.0591

ILE 1683 ALA 1684 0.0200

ALA 1684 SER 1685 0.0545

SER 1685 SER 1686 0.0603

SER 1686 SER 1687 0.0406

SER 1687 MET 1688 0.0307

MET 1688 ALA 1689 0.0600

ALA 1689 PHE 1690 0.0106

PHE 1690 ALA 1691 0.0467

ALA 1691 ILE 1692 0.0154

ILE 1692 VAL 1693 0.2499

VAL 1693 TYR 1694 0.0460

TYR 1694 GLY 1695 0.0508

GLY 1695 GLU 1696 0.0975

GLU 1696 VAL 1697 0.1078

VAL 1697 PRO 1698 0.0296

PRO 1698 LEU 1699 0.1078

LEU 1699 PRO 1700 0.1066

PRO 1700 ASP 1701 0.0070

ASP 1701 GLN 1702 0.1078

GLN 1702 PHE 1703 0.0919

PHE 1703 LEU 1704 0.0579

LEU 1704 ASP 1705 0.0491

ASP 1705 ASP 1706 0.0926

ASP 1706 MET 1707 0.1067

MET 1707 LYS 1708 0.0127

LYS 1708 THR 1709 0.0975

THR 1709 ALA 1710 0.0740

ALA 1710 ILE 1711 0.0944

ILE 1711 SER 1712 0.0105

SER 1712 SER 1713 0.1034

SER 1713 SER 1714 0.0952

SER 1714 ALA 1715 0.0745

ALA 1715 VAL 1716 0.0110

VAL 1716 SER 1717 0.0990

SER 1717 ASP 1718 0.0818

ASP 1718 PRO 1719 0.0374

PRO 1719 VAL 1720 0.1030

VAL 1720 VAL 1721 0.0316

VAL 1721 GLY 1722 0.0859

GLY 1722 HIS 1723 0.0323

HIS 1723 LEU 1724 0.0926

LEU 1724 ASP 1725 0.1094

ASP 1725 SER 1726 0.0100

SER 1726 ILE 1727 0.0813

ILE 1727 ASP 1728 0.0540

ASP 1728 ALA 1729 0.0778

ALA 1729 THR 1730 0.0490

THR 1730 GLY 1731 0.0787

GLY 1731 LYS 1732 0.0743

LYS 1732 PHE 1733 0.0463

PHE 1733 CYS 1734 0.0438

CYS 1734 ILE 1735 0.0476

ILE 1735 PHE 1736 0.0457

PHE 1736 ILE 1737 0.0598

ILE 1737 GLU 1738 0.0337

GLU 1738 ASP 1739 0.0653

ASP 1739 PRO 1740 0.0213

PRO 1740 GLU 1741 0.0781

GLU 1741 THR 1742 0.0729

THR 1742 ASP 1743 0.0789

ASP 1743 ILE 1744 0.0442

ILE 1744 LEU 1745 0.0762

LEU 1745 SER 1746 0.0042

SER 1746 SER 1747 0.0821

SER 1747 PRO 1748 0.0054

PRO 1748 ASP 1749 0.0743

ASP 1749 GLU 1750 0.0486

GLU 1750 LYS 1751 0.0349

LYS 1751 SER 1752 0.0791

SER 1752 TYR 1753 0.0803

TYR 1753 ALA 1754 0.0198

ALA 1754 SER 1755 0.0663

SER 1755 ILE 1756 0.0691

ILE 1756 GLN 1757 0.0141

GLN 1757 LYS 1758 0.0137

LYS 1758 LEU 1759 0.0843

LEU 1759 VAL 1760 0.0784

VAL 1760 THR 1761 0.0525

THR 1761 ARG 1762 0.0319

ARG 1762 CYS 1763 0.0838

CYS 1763 LYS 1764 0.0675

LYS 1764 GLY 1765 0.0270

GLY 1765 LEU 1766 0.0305

LEU 1766 ILE 1767 0.0548

ILE 1767 TRP 1768 0.0284

TRP 1768 VAL 1769 0.0663

VAL 1769 SER 1770 0.0017

SER 1770 ARG 1771 0.0327

ARG 1771 GLY 1772 0.0212

GLY 1772 GLY 1773 0.0596

GLY 1773 ALA 1774 0.0814

ALA 1774 MET 1775 0.0595

MET 1775 HIS 1776 0.0202

HIS 1776 GLY 1777 0.0831

GLY 1777 THR 1778 0.0753

THR 1778 ARG 1779 0.0670

ARG 1779 PRO 1780 0.0834

PRO 1780 ASN 1781 0.0543

ASN 1781 SER 1782 0.0399

SER 1782 SER 1783 0.0836

SER 1783 LEU 1784 0.0765

LEU 1784 LYS 1785 0.0097

LYS 1785 THR 1786 0.0830

THR 1786 GLY 1787 0.0767

GLY 1787 LEU 1788 0.0382

LEU 1788 LEU 1789 0.0717

LEU 1789 ARG 1790 0.0633

ARG 1790 THR 1791 0.0700

THR 1791 LEU 1792 0.0165

LEU 1792 ARG 1793 0.0650

ARG 1793 LEU 1794 0.0705

LEU 1794 GLU 1795 0.0607

GLU 1795 TYR 1796 0.0247

TYR 1796 THR 1797 0.0698

THR 1797 GLU 1798 0.0156

GLU 1798 LYS 1799 0.0614

LYS 1799 ARG 1800 0.0591

ARG 1800 PHE 1801 0.0162

PHE 1801 ILE 1802 0.0582

ILE 1802 SER 1803 0.0148

SER 1803 LEU 1804 0.0714

LEU 1804 ASP 1805 -0.0335

ASP 1805 LEU 1806 0.0942

LEU 1806 ASP 1807 0.0343

ASP 1807 SER 1808 0.0537

SER 1808 ALA 1809 0.0780

ALA 1809 ARG 1810 0.0317

ARG 1810 PRO 1811 0.0816

PRO 1811 GLN 1812 0.0697

GLN 1812 TRP 1813 0.0165

TRP 1813 ASN 1814 0.0927

ASN 1814 HIS 1815 0.0418

HIS 1815 ASP 1816 0.0743

ASP 1816 SER 1817 0.0943

SER 1817 ILE 1818 0.0029

ILE 1818 THR 1819 0.0936

THR 1819 THR 1820 0.0694

THR 1820 ILE 1821 0.0077

ILE 1821 ASN 1822 0.0141

ASN 1822 GLU 1823 0.0446

GLU 1823 VAL 1824 0.0484

VAL 1824 LEU 1825 0.0103

LEU 1825 CYS 1826 0.0413

CYS 1826 GLY 1827 0.0350

GLY 1827 ALA 1828 0.0493

ALA 1828 LEU 1829 0.0030

LEU 1829 ALA 1830 0.0520

ALA 1830 GLN 1831 0.0479

GLN 1831 ASN 1832 0.0197

ASN 1832 ALA 1833 0.0517

ALA 1833 ASP 1834 0.0362

ASP 1834 SER 1835 0.0095

SER 1835 SER 1836 0.0400

SER 1836 ILE 1837 0.0678

ILE 1837 LYS 1838 0.0502

LYS 1838 ASP 1839 0.0136

ASP 1839 SER 1840 0.0476

SER 1840 GLU 1841 0.0061

GLU 1841 PHE 1842 0.0484

PHE 1842 ALA 1843 0.0153

ALA 1843 GLU 1844 0.0505

GLU 1844 GLN 1845 0.0176

GLN 1845 ASP 1846 0.0500

ASP 1846 GLY 1847 0.0029

GLY 1847 GLN 1848 0.0460

GLN 1848 LEU 1849 0.0406

LEU 1849 PHE 1850 0.0420

PHE 1850 VAL 1851 0.0449

VAL 1851 PRO 1852 0.0384

PRO 1852 ARG 1853 -0.0436

ARG 1853 ILE 1854 0.0370

ILE 1854 SER 1855 0.0237

SER 1855 CYS 1856 0.0364

CYS 1856 ASP 1857 0.0182

ASP 1857 ILE 1858 0.0298

ILE 1858 ALA 1859 0.0148

ALA 1859 ARG 1860 0.0254

ARG 1860 ASN 1861 0.0248

ASN 1861 GLU 1862 0.0138

GLU 1862 ASP 1863 0.0344

ASP 1863 LEU 1864 0.0071

LEU 1864 SER 1865 0.0376

SER 1865 SER 1866 0.0037

SER 1866 ASP 1867 0.0350

ASP 1867 SER 1868 0.0331

SER 1868 ASN 1869 -0.2161

ASN 1869 SER 1870 0.0268

SER 1870 PRO 1871 0.0516

PRO 1871 ALA 1872 0.0061

ALA 1872 GLN 1873 0.0413

GLN 1873 MET 1874 0.0280

MET 1874 GLU 1875 0.0132

GLU 1875 PRO 1876 0.0053

PRO 1876 PHE 1877 0.0467

PHE 1877 HIS 1878 0.0107

HIS 1878 GLN 1879 0.0513

GLN 1879 PRO 1880 0.0222

PRO 1880 GLY 1881 0.0503

GLY 1881 LYS 1882 0.0116

LYS 1882 LEU 1883 0.0507

LEU 1883 LEU 1884 0.0273

LEU 1884 GLN 1885 0.1156

GLN 1885 MET 1886 0.0278

MET 1886 GLY 1887 0.0042

GLY 1887 ILE 1888 0.0121

ILE 1888 LYS 1889 0.0186

LYS 1889 THR 1890 0.0207

THR 1890 PRO 1891 0.0401

PRO 1891 GLY 1892 0.0374

GLY 1892 LEU 1893 0.0370

LEU 1893 ILE 1894 0.0034

ILE 1894 ASP 1895 0.0409

ASP 1895 THR 1896 0.0407

THR 1896 LEU 1897 0.0052

LEU 1897 GLN 1898 0.0344

GLN 1898 PHE 1899 0.0204

PHE 1899 SER 1900 0.0396

SER 1900 LYS 1901 0.1500

LYS 1901 THR 1902 0.0480

THR 1902 ASP 1903 0.0329

ASP 1903 ALA 1904 0.0066

ALA 1904 THR 1905 0.0474

THR 1905 ASP 1906 0.0012

ASP 1906 ASN 1907 0.0500

ASN 1907 LEU 1908 0.0500

LEU 1908 PRO 1909 0.0503

PRO 1909 ASN 1910 0.0173

ASN 1910 ASP 1911 0.0472

ASP 1911 TYR 1912 0.0446

TYR 1912 ILE 1913 0.0445

ILE 1913 GLU 1914 0.0472

GLU 1914 ILE 1915 0.0508

ILE 1915 GLU 1916 0.0500

GLU 1916 PRO 1917 0.0399

PRO 1917 LYS 1918 0.0325

LYS 1918 ALA 1919 0.0237

ALA 1919 PHE 1920 0.0115

PHE 1920 GLY 1921 0.0318

GLY 1921 LEU 1922 0.0040

LEU 1922 ASN 1923 0.0258

ASN 1923 PHE 1924 0.0090

PHE 1924 ARG 1925 0.0349

ARG 1925 ASP 1926 0.0376

ASP 1926 VAL 1927 0.0234

VAL 1927 MET 1928 0.0216

MET 1928 VAL 1929 0.0383

VAL 1929 ALA 1930 0.0383

ALA 1930 MET 1931 0.0143

MET 1931 GLY 1932 0.0325

GLY 1932 GLN 1933 0.0990

GLN 1933 LEU 1934 0.0287

LEU 1934 GLU 1935 0.0318

GLU 1935 GLU 1936 0.0073

GLU 1936 SER 1937 0.0333

SER 1937 ILE 1938 0.0013

ILE 1938 MET 1939 0.0218

MET 1939 GLY 1940 0.0010

GLY 1940 PHE 1941 0.0308

PHE 1941 GLU 1942 0.0029

GLU 1942 CYS 1943 0.0144

CYS 1943 ALA 1944 0.0009

ALA 1944 GLY 1945 0.0268

GLY 1945 VAL 1946 0.0196

VAL 1946 VAL 1947 0.0358

VAL 1947 ARG 1948 0.0356

ARG 1948 ARG 1949 0.0052

ARG 1949 VAL 1950 0.0451

VAL 1950 GLY 1951 0.0398

GLY 1951 PRO 1952 0.0246

PRO 1952 SER 1953 0.0427

SER 1953 SER 1954 0.0455

SER 1954 ALA 1955 0.0041

ALA 1955 GLY 1956 0.0424

GLY 1956 HIS 1957 0.0380

HIS 1957 ASN 1958 0.0290

ASN 1958 ILE 1959 0.0313

ILE 1959 LYS 1960 0.0363

LYS 1960 VAL 1961 0.0428

VAL 1961 GLY 1962 0.0448

GLY 1962 ASP 1963 0.0434

ASP 1963 ARG 1964 0.0324

ARG 1964 VAL 1965 0.0529

VAL 1965 CYS 1966 0.0086

CYS 1966 ALA 1967 0.0237

ALA 1967 LEU 1968 0.0082

LEU 1968 LEU 1969 0.0349

LEU 1969 GLY 1970 0.0237

GLY 1970 GLY 1971 0.0362

GLY 1971 GLN 1972 0.0449

GLN 1972 TRP 1973 0.0465

TRP 1973 THR 1974 0.0292

THR 1974 ASN 1975 0.0164

ASN 1975 THR 1976 0.0403

THR 1976 VAL 1977 0.0462

VAL 1977 ARG 1978 0.0476

ARG 1978 VAL 1979 0.0483

VAL 1979 HIS 1980 0.0450

HIS 1980 TRP 1981 -0.0381

TRP 1981 HIS 1982 0.0364

HIS 1982 SER 1983 0.0369

SER 1983 VAL 1984 0.0105

VAL 1984 ALA 1985 0.0234

ALA 1985 PRO 1986 0.0111

PRO 1986 ILE 1987 0.0431

ILE 1987 PRO 1988 0.0175

PRO 1988 GLN 1989 0.0288

GLN 1989 ALA 1990 0.0424

ALA 1990 MET 1991 0.0002

MET 1991 ASP 1992 0.0341

ASP 1992 TRP 1993 0.0215

TRP 1993 GLU 1994 0.0208

GLU 1994 THR 1995 0.0418

THR 1995 ALA 1996 0.0422

ALA 1996 ALA 1997 0.0227

ALA 1997 SER 1998 0.0314

SER 1998 ILE 1999 0.0389

ILE 1999 PRO 2000 0.0345

PRO 2000 ILE 2001 0.0008

ILE 2001 VAL 2002 0.0397

VAL 2002 PHE 2003 0.0238

PHE 2003 VAL 2004 0.0363

VAL 2004 THR 2005 0.0044

THR 2005 ALA 2006 0.0369

ALA 2006 TYR 2007 0.0252

TYR 2007 ILE 2008 0.0230

ILE 2008 SER 2009 0.0191

SER 2009 LEU 2010 0.0315

LEU 2010 VAL 2011 0.0176

VAL 2011 LYS 2012 0.0355

LYS 2012 ILE 2013 -0.0021

ILE 2013 ALA 2014 0.0303

ALA 2014 ARG 2015 0.0115

ARG 2015 MET 2016 0.0313

MET 2016 GLN 2017 0.0240

GLN 2017 ALA 2018 0.0234

ALA 2018 GLY 2019 0.0188

GLY 2019 GLU 2020 0.0119

GLU 2020 THR 2021 0.0227

THR 2021 VAL 2022 0.0308

VAL 2022 LEU 2023 0.0209

LEU 2023 ILE 2024 0.0270

ILE 2024 HIS 2025 0.0208

HIS 2025 ALA 2026 0.0274

ALA 2026 ALA 2027 0.0109

ALA 2027 SER 2028 0.0250

SER 2028 GLY 2029 -0.0153

GLY 2029 GLY 2030 0.0180

GLY 2030 VAL 2031 0.0276

VAL 2031 GLY 2032 0.0316

GLY 2032 GLN 2033 0.0047

GLN 2033 ALA 2034 0.0300

ALA 2034 ALA 2035 0.0186

ALA 2035 ILE 2036 0.0320

ILE 2036 ILE 2037 0.0028

ILE 2037 LEU 2038 0.0333

LEU 2038 ALA 2039 0.0214

ALA 2039 LYS 2040 0.0172

LYS 2040 HIS 2041 0.0203

HIS 2041 VAL 2042 0.0212

VAL 2042 GLY 2043 0.0339

GLY 2043 ALA 2044 0.0023

ALA 2044 GLU 2045 0.0606

GLU 2045 ILE 2046 0.0307

ILE 2046 PHE 2047 0.0092

PHE 2047 ALA 2048 0.0345

ALA 2048 THR 2049 0.0197

THR 2049 VAL 2050 0.0336

VAL 2050 GLY 2051 0.0247

GLY 2051 THR 2052 0.0299

THR 2052 ASP 2053 0.0266

ASP 2053 GLU 2054 0.0104

GLU 2054 LYS 2055 0.0347

LYS 2055 ARG 2056 0.0340

ARG 2056 ASP 2057 0.0134

ASP 2057 LEU 2058 0.0232

LEU 2058 LEU 2059 0.0333

LEU 2059 ILE 2060 0.0334

ILE 2060 LYS 2061 0.0082

LYS 2061 GLU 2062 0.0252

GLU 2062 TYR 2063 0.0295

TYR 2063 LYS 2064 0.0318

LYS 2064 ILE 2065 0.0058

ILE 2065 PRO 2066 0.0230

PRO 2066 ASP 2067 0.0171

ASP 2067 ASP 2068 0.0172

ASP 2068 HIS 2069 0.0306

HIS 2069 ILE 2070 0.0323

ILE 2070 PHE 2071 0.0058

PHE 2071 SER 2072 0.0261

SER 2072 SER 2073 0.0333

SER 2073 ARG 2074 0.0126

ARG 2074 ASN 2075 0.0187

ASN 2075 ALA 2076 0.0316

ALA 2076 LEU 2077 0.0222

LEU 2077 PHE 2078 0.0029

PHE 2078 ALA 2079 0.0216

ALA 2079 LYS 2080 0.0195

LYS 2080 SER 2081 0.0098

SER 2081 ILE 2082 0.0132

ILE 2082 ARG 2083 0.0174

ARG 2083 GLN 2084 0.0241

GLN 2084 ARG 2085 0.0006

ARG 2085 THR 2086 0.0232

THR 2086 ASN 2087 0.0163

ASN 2087 GLY 2088 0.0125

GLY 2088 LYS 2089 0.0138

LYS 2089 GLY 2090 0.0239

GLY 2090 VAL 2091 0.0088

VAL 2091 ASP 2092 0.0176

ASP 2092 VAL 2093 0.0889

VAL 2093 VAL 2094 0.0135

VAL 2094 LEU 2095 0.0105

LEU 2095 ASN 2096 0.0085

ASN 2096 CYS 2097 0.0148

CYS 2097 LEU 2098 0.0050

LEU 2098 ALA 2099 0.0057

ALA 2099 GLY 2100 0.0003

GLY 2100 GLY 2101 0.0126

GLY 2101 LEU 2102 0.0031

LEU 2102 LEU 2103 0.0139

LEU 2103 GLN 2104 0.0052

GLN 2104 GLU 2105 0.0144

GLU 2105 SER 2106 0.0019

SER 2106 PHE 2107 0.0127

PHE 2107 ASP 2108 0.0091

ASP 2108 CYS 2109 0.0158

CYS 2109 LEU 2110 0.0096

LEU 2110 ALA 2111 0.0093

ALA 2111 ASP 2112 0.0074

ASP 2112 PHE 2113 0.0094

PHE 2113 GLY 2114 0.0083

GLY 2114 ARG 2115 0.0096

ARG 2115 PHE 2116 0.0084

PHE 2116 ILE 2117 0.0084

ILE 2117 GLU 2118 0.0075

GLU 2118 ILE 2119 0.0071

ILE 2119 GLY 2120 0.0063

GLY 2120 LYS 2121 0.0051

LYS 2121 ARG 2122 0.0066

ARG 2122 ASP 2123 0.0063

ASP 2123 ILE 2124 0.0096

ILE 2124 GLU 2125 0.0005

GLU 2125 LEU 2126 0.0044

LEU 2126 ASN 2127 0.0044

ASN 2127 HIS 2128 0.0063

HIS 2128 CYS 2129 0.0046

CYS 2129 LEU 2130 0.0050

LEU 2130 ASN 2131 0.0054

ASN 2131 MET 2132 0.0055

MET 2132 GLY 2133 0.0065

GLY 2133 MET 2134 0.0005

MET 2134 PHE 2135 0.0060

PHE 2135 ALA 2136 0.0047

ALA 2136 ARG 2137 0.0012

ARG 2137 SER 2138 0.0065

SER 2138 ALA 2139 0.0042

ALA 2139 THR 2140 0.0058

THR 2140 PHE 2141 -0.0279

PHE 2141 THR 2142 0.0154

THR 2142 ALA 2143 0.0183

ALA 2143 VAL 2144 0.0058

VAL 2144 ASP 2145 0.0184

ASP 2145 LEU 2146 0.0054

LEU 2146 ILE 2147 0.0144

ILE 2147 ALA 2148 0.0113

ALA 2148 ILE 2149 0.0073

ILE 2149 GLY 2150 0.0132

GLY 2150 ARG 2151 0.0081

ARG 2151 ASP 2152 0.0168

ASP 2152 ARG 2153 0.0077

ARG 2153 SER 2154 0.0063

SER 2154 TYR 2155 0.0128

TYR 2155 MET 2156 0.0184

MET 2156 PHE 2157 0.0793

PHE 2157 ALA 2158 0.0122

ALA 2158 GLU 2159 0.0397

GLU 2159 ALA 2160 0.0361

ALA 2160 LEU 2161 0.0314

LEU 2161 PRO 2162 0.0054

PRO 2162 LYS 2163 0.0388

LYS 2163 ILE 2164 0.0359

ILE 2164 MET 2165 0.0138

MET 2165 THR 2166 0.0260

THR 2166 LEU 2167 0.0327

LEU 2167 LEU 2168 0.0389

LEU 2168 GLN 2169 0.0042

GLN 2169 GLU 2170 0.0384

GLU 2170 LYS 2171 0.0321

LYS 2171 ALA 2172 0.0252

ALA 2172 ILE 2173 0.0306

ILE 2173 ARG 2174 0.0468

ARG 2174 PRO 2175 0.0320

PRO 2175 VAL 2176 0.0118

VAL 2176 THR 2177 0.0474

THR 2177 PRO 2178 0.0441

PRO 2178 ILE 2179 0.0473

ILE 2179 SER 2180 0.0336

SER 2180 ILE 2181 0.0417

ILE 2181 TYR 2182 0.0324

TYR 2182 LYS 2183 0.0455

LYS 2183 ILE 2184 0.0339

ILE 2184 GLY 2185 0.0418

GLY 2185 ASP 2186 0.0408

ASP 2186 ILE 2187 0.0393

ILE 2187 GLU 2188 0.0080

GLU 2188 THR 2189 -0.0286

THR 2189 ALA 2190 0.0330

ALA 2190 PHE 2191 0.0099

PHE 2191 ARG 2192 0.0286

ARG 2192 LEU 2193 0.0231

LEU 2193 MET 2194 0.0378

MET 2194 GLN 2195 0.0006

GLN 2195 ALA 2196 0.0383

ALA 2196 GLY 2197 0.0293

GLY 2197 LYS 2198 0.0230

LYS 2198 HIS 2199 0.0113

HIS 2199 MET 2200 0.0222

MET 2200 GLY 2201 0.0244

GLY 2201 LYS 2202 0.0383

LYS 2202 ILE 2203 0.0372

ILE 2203 VAL 2204 0.0230

VAL 2204 ILE 2205 0.0495

ILE 2205 THR 2206 0.0242

THR 2206 ALA 2207 0.0348

ALA 2207 PRO 2208 0.0301

PRO 2208 GLU 2209 0.0356

GLU 2209 ASP 2210 0.0158

ASP 2210 ALA 2211 0.0238

ALA 2211 MET 2212 0.0042

MET 2212 VAL 2213 0.0249

VAL 2213 PRO 2214 0.0039

PRO 2214 VAL 2215 0.0354

VAL 2215 ILE 2216 0.0176

ILE 2216 THR 2217 0.0351

THR 2217 ARG 2218 0.0324

ARG 2218 PRO 2219 0.0318

PRO 2219 PRO 2220 0.0231

PRO 2220 LYS 2221 0.2831

LYS 2221 LEU 2222 0.0666

LEU 2222 GLN 2223 0.0050

GLN 2223 LEU 2224 0.0656

LEU 2224 ARG 2225 0.0099

ARG 2225 PRO 2226 0.0542

PRO 2226 ASP 2227 0.0477

ASP 2227 ALA 2228 0.0265

ALA 2228 SER 2229 0.0370

SER 2229 TYR 2230 0.0023

TYR 2230 LEU 2231 0.0450

LEU 2231 ILE 2232 0.0121

ILE 2232 VAL 2233 0.0433

VAL 2233 GLY 2234 0.0411

GLY 2234 GLY 2235 0.0420

GLY 2235 LEU 2236 0.0600

LEU 2236 GLY 2237 0.0077

GLY 2237 GLY 2238 0.0428

GLY 2238 ILE 2239 0.0501

ILE 2239 GLY 2240 0.0115

GLY 2240 ARG 2241 0.0463

ARG 2241 SER 2242 0.0467

SER 2242 LEU 2243 0.0384

LEU 2243 CYS 2244 0.0180

CYS 2244 LYS 2245 0.0508

LYS 2245 ASN 2246 0.0496

ASN 2246 PHE 2247 0.0240

PHE 2247 VAL 2248 0.0294

VAL 2248 GLU 2249 0.0468

GLU 2249 ASN 2250 0.0504

ASN 2250 GLY 2251 0.0062

GLY 2251 ALA 2252 0.0507

ALA 2252 ARG 2253 0.0658

ARG 2253 SER 2254 0.0696

SER 2254 LEU 2255 0.0144

LEU 2255 VAL 2256 0.0667

VAL 2256 LEU 2257 0.0240

LEU 2257 LEU 2258 0.0587

LEU 2258 SER 2259 0.0431

SER 2259 ARG 2260 0.0644

ARG 2260 ASN 2261 0.0695

ASN 2261 ALA 2262 0.0217

ALA 2262 ASN 2263 0.0699

ASN 2263 VAL 2264 0.0448

VAL 2264 SER 2265 0.0268

SER 2265 GLN 2266 0.0646

GLN 2266 GLN 2267 0.0273

GLN 2267 SER 2268 0.0568

SER 2268 GLY 2269 0.1130

GLY 2269 GLU 2270 0.0586

GLU 2270 PHE 2271 0.0570

PHE 2271 LEU 2272 0.0209

LEU 2272 ASP 2273 0.0415

ASP 2273 GLU 2274 0.0466

GLU 2274 LEU 2275 0.0589

LEU 2275 ARG 2276 0.0060

ARG 2276 SER 2277 0.0608

SER 2277 THR 2278 0.0605

THR 2278 GLY 2279 0.0222

GLY 2279 CYS 2280 0.0435

CYS 2280 ILE 2281 0.0551

ILE 2281 VAL 2282 0.0241

VAL 2282 GLY 2283 0.0615

GLY 2283 VAL 2284 0.0277

VAL 2284 VAL 2285 -0.1347

VAL 2285 ASP 2286 0.0376

ASP 2286 CYS 2287 0.0672

CYS 2287 ASP 2288 0.0133

ASP 2288 ILE 2289 0.0783

ILE 2289 SER 2290 0.0356

SER 2290 SER 2291 0.0486

SER 2291 LYS 2292 0.0525

LYS 2292 THR 2293 0.0457

THR 2293 GLN 2294 0.0783

GLN 2294 VAL 2295 0.0776

VAL 2295 GLU 2296 0.0396

GLU 2296 ALA 2297 0.0629

ALA 2297 THR 2298 0.0778

THR 2298 MET 2299 0.0687

MET 2299 LEU 2300 0.0321

LEU 2300 ARG 2301 0.0562

ARG 2301 LEU 2302 0.0753

LEU 2302 LYS 2303 0.0438

LYS 2303 LYS 2304 0.0442

LYS 2304 ASP 2305 0.0713

ASP 2305 MET 2306 0.0689

MET 2306 LEU 2307 0.0720

LEU 2307 PRO 2308 0.0674

PRO 2308 ILE 2309 0.0010

ILE 2309 ARG 2310 0.0726

ARG 2310 GLY 2311 0.0064

GLY 2311 ILE 2312 0.0274

ILE 2312 VAL 2313 0.0213

VAL 2313 HIS 2314 0.0422

HIS 2314 ALA 2315 0.0483

ALA 2315 GLY 2316 0.0719

GLY 2316 MET 2317 0.0795

MET 2317 VAL 2318 0.0462

VAL 2318 LEU 2319 0.0179

LEU 2319 GLN 2320 0.0342

GLN 2320 ASP 2321 0.0334

ASP 2321 SER 2322 0.0172

SER 2322 VAL 2323 0.0342

VAL 2323 PHE 2324 0.0853

PHE 2324 GLU 2325 0.0274

GLU 2325 ARG 2326 0.0721

ARG 2326 MET 2327 0.0087

MET 2327 SER 2328 0.0788

SER 2328 LEU 2329 0.0587

LEU 2329 ASP 2330 0.0433

ASP 2330 ASP 2331 0.0847

ASP 2331 TYR 2332 0.0856

TYR 2332 ASN 2333 0.0933

ASN 2333 THR 2334 0.0692

THR 2334 ALA 2335 0.0791

ALA 2335 ILE 2336 0.0744

ILE 2336 ARG 2337 0.0293

ARG 2337 PRO 2338 0.0482

PRO 2338 LYS 2339 0.0746

LYS 2339 VAL 2340 0.0780

VAL 2340 GLN 2341 0.0544

GLN 2341 GLY 2342 0.0477

GLY 2342 SER 2343 0.0778

SER 2343 TRP 2344 0.0788

TRP 2344 ASN 2345 0.0469

ASN 2345 LEU 2346 0.0592

LEU 2346 HIS 2347 0.0791

HIS 2347 SER 2348 0.0720

SER 2348 GLY 2349 0.0376

GLY 2349 LEU 2350 0.0697

LEU 2350 SER 2351 0.0803

SER 2351 ASP 2352 0.0019

ASP 2352 CYS 2353 0.0814

CYS 2353 ASP 2354 0.0790

ASP 2354 LEU 2355 0.0419

LEU 2355 ASP 2356 0.0810

ASP 2356 PHE 2357 0.0059

PHE 2357 PHE 2358 0.0402

PHE 2358 ILE 2359 0.0307

ILE 2359 MET 2360 0.0243

MET 2360 LEU 2361 0.0501

LEU 2361 SER 2362 0.0250

SER 2362 SER 2363 0.0178

SER 2363 LEU 2364 0.0449

LEU 2364 ALA 2365 -0.1134

ALA 2365 GLY 2366 0.0808

GLY 2366 VAL 2367 0.0817

VAL 2367 SER 2368 0.0382

SER 2368 GLY 2369 0.0697

GLY 2369 SER 2370 0.0820

SER 2370 ALA 2371 0.0273

ALA 2371 SER 2372 0.0818

SER 2372 GLN 2373 0.0155

GLN 2373 ALA 2374 0.0813

ALA 2374 ASN 2375 0.0363

ASN 2375 TYR 2376 0.0496

TYR 2376 THR 2377 0.0774

THR 2377 ALA 2378 0.0839

ALA 2378 GLY 2379 0.0131

GLY 2379 GLY 2380 0.0810

GLY 2380 ALA 2381 0.0726

ALA 2381 TYR 2382 0.0458

TYR 2382 GLN 2383 0.0316

GLN 2383 ASP 2384 0.0713

ASP 2384 ALA 2385 0.0755

ALA 2385 LEU 2386 0.0226

LEU 2386 ALA 2387 0.0615

ALA 2387 LYS 2388 0.0703

LYS 2388 TYR 2389 0.0695

TYR 2389 ARG 2390 0.0149

ARG 2390 ARG 2391 0.0747

ARG 2391 ALA 2392 0.0706

ALA 2392 GLN 2393 0.0370

GLN 2393 GLY 2394 0.0458

GLY 2394 LEU 2395 0.0755

LEU 2395 SER 2396 0.0749

SER 2396 ALA 2397 0.0302

ALA 2397 VAL 2398 0.0343

VAL 2398 SER 2399 0.0125

SER 2399 ILE 2400 0.0535

ILE 2400 ASP 2401 0.0019

ASP 2401 LEU 2402 0.0591

LEU 2402 GLY 2403 0.0245

GLY 2403 MET 2404 0.0573

MET 2404 VAL 2405 0.0218

VAL 2405 GLN 2406 0.0557

GLN 2406 SER 2407 0.0236

SER 2407 VAL 2408 0.0513

VAL 2408 GLY 2409 0.0547

GLY 2409 TYR 2410 0.0145

TYR 2410 VAL 2411 0.0392

VAL 2411 ALA 2412 0.0455

ALA 2412 GLU 2413 0.0586

GLU 2413 THR 2414 0.0041

THR 2414 LYS 2415 0.0396

LYS 2415 GLY 2416 0.0347

GLY 2416 VAL 2417 0.0612

VAL 2417 ALA 2418 0.0631

ALA 2418 GLU 2419 0.0182

GLU 2419 ARG 2420 0.0572

ARG 2420 LEU 2421 0.0419

LEU 2421 VAL 2422 0.0717

VAL 2422 ARG 2423 0.0008

ARG 2423 MET 2424 0.0710

MET 2424 GLY 2425 0.0524

GLY 2425 TYR 2426 0.0111

TYR 2426 SER 2427 0.0395

SER 2427 PRO 2428 0.0441

PRO 2428 ILE 2429 0.0029

ILE 2429 SER 2430 0.0288

SER 2430 GLU 2431 0.0118

GLU 2431 MET 2432 0.0361

MET 2432 GLU 2433 0.0355

GLU 2433 VAL 2434 0.0429

VAL 2434 LEU 2435 0.0038

LEU 2435 LYS 2436 0.0455

LYS 2436 ILE 2437 0.0385

ILE 2437 VAL 2438 0.0232

VAL 2438 GLU 2439 0.0231

GLU 2439 HIS 2440 0.0400

HIS 2440 ALA 2441 0.0452

ALA 2441 ILE 2442 0.0027

ILE 2442 THR 2443 0.0419

THR 2443 ASN 2444 0.0299

ASN 2444 PRO 2445 0.1585

PRO 2445 PRO 2446 0.0280

PRO 2446 PRO 2447 0.0404

PRO 2447 GLU 2448 0.0279

GLU 2448 ALA 2449 0.0432

ALA 2449 SER 2450 0.0089

SER 2450 SER 2451 0.0485

SER 2451 ALA 2452 0.0467

ALA 2452 GLN 2453 0.0146

GLN 2453 ILE 2454 0.0500

ILE 2454 ILE 2455 0.0054

ILE 2455 THR 2456 0.0500

THR 2456 GLY 2457 0.0249

GLY 2457 ILE 2458 0.0237

ILE 2458 SER 2459 0.0382

SER 2459 THR 2460 0.0512

THR 2460 LYS 2461 0.0335

LYS 2461 PRO 2462 0.0153

PRO 2462 GLY 2463 0.0206

GLY 2463 ARG 2464 0.0057

ARG 2464 HIS 2465 0.0348

HIS 2465 TRP 2466 0.0359

TRP 2466 THR 2467 0.0034

THR 2467 GLU 2468 0.0354

GLU 2468 SER 2469 0.0289

SER 2469 SER 2470 0.0217

SER 2470 TRP 2471 0.0179

TRP 2471 LEU 2472 0.0284

LEU 2472 GLN 2473 0.0118

GLN 2473 ASP 2474 0.0354

ASP 2474 ALA 2475 0.0340

ALA 2475 ARG 2476 0.0087

ARG 2476 PHE 2477 -0.1286

PHE 2477 ALA 2478 0.0238

ALA 2478 THR 2479 0.0047

THR 2479 LEU 2480 0.0225

LEU 2480 ARG 2481 0.0132

ARG 2481 GLU 2482 0.0255

GLU 2482 ARG 2483 0.0013

ARG 2483 ALA 2484 0.0249

ALA 2484 ARG 2485 0.0190

ARG 2485 ASP 2486 0.0122

ASP 2486 VAL 2487 0.0172

VAL 2487 LYS 2488 0.0138

LYS 2488 GLU 2489 0.0264

GLU 2489 LEU 2490 0.0008

LEU 2490 SER 2491 0.0268

SER 2491 ASN 2492 0.0167

ASN 2492 SER 2493 0.0007

SER 2493 GLN 2494 0.0013

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** sdgklnrdh ***

CA strain for 22101813491974862

--- normal mode 23 ---

Should you encounter any unexpected behaviour,
please let us know.

* sdgklnrdh *