Should you encounter any unexpected behaviour,
please let us know.

* Q20HUZ_NMA *

CA strain for 220512003338119574

--- normal mode 8 ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA i CA i+1 vari
MET 1 ASP 2 0.0000

ASP 2 ASP 3 -0.0002

ASP 3 ASP 4 -0.0074

ASP 4 PHE 5 -0.0001

PHE 5 ILE 6 -0.0002

ILE 6 GLN 7 -0.0030

GLN 7 SER 8 0.0003

SER 8 LEU 9 0.0003

LEU 9 SER 10 -0.1065

SER 10 THR 11 -0.0004

THR 11 PRO 12 -0.0003

PRO 12 TYR 13 -0.0393

TYR 13 GLY 14 -0.0000

GLY 14 GLU 15 0.0004

GLU 15 PRO 16 -0.0453

PRO 16 SER 17 -0.0002

SER 17 TYR 18 0.0004

TYR 18 ARG 19 0.0036

ARG 19 GLU 20 -0.0001

GLU 20 SER 21 -0.0001

SER 21 ALA 22 0.0196

ALA 22 GLU 23 0.0004

GLU 23 ARG 24 -0.0001

ARG 24 LEU 25 -0.0097

LEU 25 LYS 26 -0.0001

LYS 26 GLY 27 -0.0002

GLY 27 GLU 28 -0.0303

GLU 28 ILE 29 -0.0000

ILE 29 LYS 30 -0.0003

LYS 30 LYS 31 -0.0171

LYS 31 MET 32 -0.0004

MET 32 PHE 33 0.0000

PHE 33 ARG 34 0.0057

ARG 34 SER 35 0.0003

SER 35 MET 36 0.0001

MET 36 SER 37 0.0143

SER 37 LYS 38 -0.0001

LYS 38 GLU 39 -0.0000

GLU 39 ASP 40 0.0252

ASP 40 GLU 41 -0.0005

GLU 41 GLU 42 0.0002

GLU 42 LEU 43 -0.0026

LEU 43 ILE 44 0.0000

ILE 44 THR 45 -0.0004

THR 45 PRO 46 0.0044

PRO 46 LEU 47 0.0002

LEU 47 ASN 48 -0.0002

ASN 48 ASP 49 0.0054

ASP 49 LEU 50 0.0001

LEU 50 ILE 51 -0.0005

ILE 51 GLN 52 -0.0191

GLN 52 ARG 53 -0.0001

ARG 53 LEU 54 0.0002

LEU 54 TRP 55 0.0042

TRP 55 MET 56 -0.0002

MET 56 VAL 57 0.0001

VAL 57 ASP 58 0.0095

ASP 58 SER 59 0.0002

SER 59 VAL 60 0.0003

VAL 60 GLU 61 0.0131

GLU 61 ARG 62 -0.0001

ARG 62 LEU 63 0.0000

LEU 63 GLY 64 0.0089

GLY 64 ILE 65 0.0000

ILE 65 ASP 66 0.0003

ASP 66 ARG 67 -0.0051

ARG 67 HIS 68 0.0000

HIS 68 PHE 69 0.0004

PHE 69 LYS 70 0.0505

LYS 70 ASN 71 0.0001

ASN 71 GLU 72 -0.0001

GLU 72 ILE 73 0.0694

ILE 73 LYS 74 0.0001

LYS 74 SER 75 -0.0002

SER 75 ALA 76 -0.0029

ALA 76 LEU 77 -0.0002

LEU 77 ASP 78 -0.0001

ASP 78 TYR 79 -0.0112

TYR 79 VAL 80 -0.0001

VAL 80 TYR 81 -0.0003

TYR 81 SER 82 -0.0053

SER 82 TYR 83 0.0001

TYR 83 TRP 84 0.0002

TRP 84 ASN 85 -0.0251

ASN 85 GLU 86 -0.0003

GLU 86 LYS 87 -0.0002

LYS 87 GLY 88 0.0155

GLY 88 ILE 89 -0.0001

ILE 89 GLY 90 -0.0003

GLY 90 CYS 91 -0.0116

CYS 91 GLY 92 0.0001

GLY 92 ARG 93 0.0002

ARG 93 ASP 94 -0.0178

ASP 94 SER 95 0.0001

SER 95 VAL 96 -0.0000

VAL 96 VAL 97 0.0049

VAL 97 ALA 98 -0.0003

ALA 98 ASP 99 -0.0000

ASP 99 LEU 100 0.0282

LEU 100 ASN 101 -0.0003

ASN 101 SER 102 -0.0001

SER 102 THR 103 0.0007

THR 103 ALA 104 -0.0001

ALA 104 LEU 105 0.0000

LEU 105 GLY 106 -0.0106

GLY 106 PHE 107 -0.0002

PHE 107 ARG 108 0.0001

ARG 108 THR 109 -0.0000

THR 109 LEU 110 0.0000

LEU 110 ARG 111 -0.0001

ARG 111 LEU 112 -0.0326

LEU 112 HIS 113 -0.0001

HIS 113 GLY 114 0.0004

GLY 114 TYR 115 -0.0522

TYR 115 ASN 116 -0.0002

ASN 116 VAL 117 -0.0000

VAL 117 SER 118 -0.0178

SER 118 SER 119 0.0000

SER 119 GLU 120 0.0000

GLU 120 VAL 121 0.0194

VAL 121 LEU 122 -0.0001

LEU 122 LYS 123 0.0001

LYS 123 VAL 124 0.0044

VAL 124 PHE 125 -0.0002

PHE 125 GLU 126 -0.0000

GLU 126 ASP 127 -0.0575

ASP 127 GLN 128 -0.0000

GLN 128 ASN 129 0.0001

ASN 129 GLY 130 -0.0243

GLY 130 GLN 131 0.0004

GLN 131 PHE 132 -0.0002

PHE 132 ALA 133 -0.0322

ALA 133 CYS 134 0.0000

CYS 134 SER 135 -0.0002

SER 135 PRO 136 -0.0060

PRO 136 SER 137 0.0001

SER 137 LYS 138 -0.0000

LYS 138 THR 139 -0.0102

THR 139 GLU 140 0.0000

GLU 140 GLY 141 0.0001

GLY 141 GLU 142 0.0009

GLU 142 ILE 143 -0.0001

ILE 143 ARG 144 0.0000

ARG 144 SER 145 -0.0012

SER 145 ALA 146 0.0001

ALA 146 LEU 147 0.0000

LEU 147 ASN 148 -0.0078

ASN 148 LEU 149 -0.0002

LEU 149 TYR 150 0.0005

TYR 150 ARG 151 -0.0087

ARG 151 ALA 152 0.0001

ALA 152 SER 153 0.0003

SER 153 LEU 154 0.0384

LEU 154 ILE 155 -0.0000

ILE 155 ALA 156 -0.0002

ALA 156 PHE 157 -0.0928

PHE 157 PRO 158 0.0003

PRO 158 GLY 159 0.0001

GLY 159 GLU 160 0.0431

GLU 160 LYS 161 -0.0002

LYS 161 VAL 162 0.0003

VAL 162 MET 163 0.0199

MET 163 GLU 164 -0.0002

GLU 164 ASP 165 0.0000

ASP 165 ALA 166 0.0032

ALA 166 GLU 167 -0.0001

GLU 167 ILE 168 0.0003

ILE 168 PHE 169 -0.0241

PHE 169 SER 170 -0.0002

SER 170 SER 171 -0.0001

SER 171 ARG 172 -0.0169

ARG 172 TYR 173 -0.0001

TYR 173 LEU 174 -0.0002

LEU 174 LYS 175 -0.0185

LYS 175 GLU 176 0.0003

GLU 176 ALA 177 -0.0000

ALA 177 VAL 178 0.0027

VAL 178 GLN 179 -0.0003

GLN 179 LYS 180 0.0003

LYS 180 ILE 181 -0.0066

ILE 181 PRO 182 -0.0000

PRO 182 ASP 183 -0.0002

ASP 183 CYS 184 -0.0003

CYS 184 SER 185 -0.0001

SER 185 LEU 186 -0.0002

LEU 186 SER 187 -0.0080

SER 187 GLN 188 -0.0001

GLN 188 GLU 189 -0.0001

GLU 189 ILE 190 -0.0161

ILE 190 ALA 191 0.0002

ALA 191 TYR 192 -0.0001

TYR 192 ALA 193 0.0146

ALA 193 LEU 194 -0.0002

LEU 194 GLU 195 -0.0002

GLU 195 TYR 196 0.0039

TYR 196 GLY 197 -0.0002

GLY 197 TRP 198 -0.0000

TRP 198 HIS 199 -0.0021

HIS 199 THR 200 -0.0000

THR 200 ASN 201 0.0002

ASN 201 MET 202 0.0189

MET 202 PRO 203 -0.0003

PRO 203 ARG 204 0.0001

ARG 204 LEU 205 0.0350

LEU 205 GLU 206 -0.0004

GLU 206 ALA 207 -0.0000

ALA 207 ARG 208 -0.0049

ARG 208 ASN 209 -0.0001

ASN 209 TYR 210 -0.0000

TYR 210 MET 211 -0.0314

MET 211 ASP 212 -0.0001

ASP 212 VAL 213 -0.0003

VAL 213 PHE 214 0.0060

PHE 214 GLY 215 0.0001

GLY 215 HIS 216 0.0001

HIS 216 PRO 217 0.0045

PRO 217 SER 218 -0.0001

SER 218 SER 219 -0.0003

SER 219 PRO 220 0.0056

PRO 220 TRP 221 0.0000

TRP 221 LEU 222 -0.0001

LEU 222 LYS 223 0.0208

LYS 223 LYS 224 -0.0004

LYS 224 ASN 225 0.0000

ASN 225 LYS 226 -0.0048

LYS 226 THR 227 -0.0004

THR 227 GLN 228 0.0004

GLN 228 TYR 229 0.0033

TYR 229 MET 230 0.0005

MET 230 ASP 231 -0.0001

ASP 231 GLY 232 0.0090

GLY 232 GLU 233 0.0005

GLU 233 LYS 234 -0.0002

LYS 234 LEU 235 0.0082

LEU 235 LEU 236 0.0002

LEU 236 GLU 237 0.0000

GLU 237 LEU 238 0.0145

LEU 238 ALA 239 -0.0001

ALA 239 LYS 240 0.0002

LYS 240 LEU 241 0.0293

LEU 241 GLU 242 0.0001

GLU 242 PHE 243 -0.0000

PHE 243 ASN 244 -0.0318

ASN 244 ILE 245 -0.0003

ILE 245 PHE 246 0.0001

PHE 246 HIS 247 -0.0481

HIS 247 SER 248 -0.0002

SER 248 LEU 249 -0.0001

LEU 249 GLN 250 -0.0430

GLN 250 GLN 251 -0.0001

GLN 251 GLU 252 0.0002

GLU 252 GLU 253 0.0112

GLU 253 LEU 254 -0.0001

LEU 254 GLN 255 -0.0002

GLN 255 TYR 256 0.0379

TYR 256 ILE 257 0.0002

ILE 257 SER 258 0.0002

SER 258 ARG 259 0.0139

ARG 259 TRP 260 0.0001

TRP 260 TRP 261 -0.0000

TRP 261 LYS 262 -0.0121

LYS 262 ASP 263 -0.0001

ASP 263 SER 264 -0.0003

SER 264 GLY 265 -0.0055

GLY 265 LEU 266 0.0001

LEU 266 PRO 267 -0.0000

PRO 267 LYS 268 -0.0116

LYS 268 LEU 269 0.0000

LEU 269 ALA 270 -0.0004

ALA 270 PHE 271 0.0015

PHE 271 SER 272 -0.0001

SER 272 ARG 273 0.0003

ARG 273 HIS 274 -0.0785

HIS 274 ARG 275 0.0001

ARG 275 HIS 276 0.0002

HIS 276 VAL 277 0.0141

VAL 277 GLU 278 -0.0001

GLU 278 TYR 279 0.0000

TYR 279 TYR 280 -0.0209

TYR 280 THR 281 -0.0003

THR 281 LEU 282 -0.0001

LEU 282 GLY 283 -0.0085

GLY 283 SER 284 0.0001

SER 284 CYS 285 -0.0002

CYS 285 ILE 286 -0.0050

ILE 286 ALA 287 0.0001

ALA 287 THR 288 0.0001

THR 288 ASP 289 0.0245

ASP 289 PRO 290 -0.0002

PRO 290 LYS 291 -0.0003

LYS 291 HIS 292 0.0027

HIS 292 ARG 293 -0.0005

ARG 293 ALA 294 -0.0001

ALA 294 PHE 295 0.0185

PHE 295 ARG 296 0.0001

ARG 296 LEU 297 -0.0003

LEU 297 GLY 298 0.0221

GLY 298 PHE 299 0.0001

PHE 299 VAL 300 -0.0000

VAL 300 LYS 301 0.0150

LYS 301 THR 302 -0.0000

THR 302 CYS 303 0.0003

CYS 303 HIS 304 0.0026

HIS 304 LEU 305 0.0002

LEU 305 ASN 306 -0.0002

ASN 306 THR 307 -0.0002

THR 307 VAL 308 -0.0004

VAL 308 LEU 309 -0.0000

LEU 309 ASP 310 -0.0094

ASP 310 ASP 311 -0.0001

ASP 311 ILE 312 0.0002

ILE 312 TYR 313 -0.0226

TYR 313 ASP 314 -0.0001

ASP 314 THR 315 -0.0000

THR 315 PHE 316 0.0011

PHE 316 GLY 317 -0.0002

GLY 317 THR 318 0.0004

THR 318 MET 319 -0.0234

MET 319 ASP 320 -0.0003

ASP 320 GLU 321 0.0003

GLU 321 ILE 322 -0.0026

ILE 322 GLU 323 0.0000

GLU 323 LEU 324 0.0001

LEU 324 PHE 325 0.0012

PHE 325 THR 326 -0.0001

THR 326 GLU 327 0.0000

GLU 327 ALA 328 0.0091

ALA 328 VAL 329 0.0003

VAL 329 ARG 330 0.0001

ARG 330 ARG 331 0.0044

ARG 331 TRP 332 -0.0001

TRP 332 ASP 333 0.0000

ASP 333 PRO 334 -0.0120

PRO 334 SER 335 -0.0003

SER 335 GLU 336 0.0002

GLU 336 THR 337 -0.0008

THR 337 GLU 338 0.0001

GLU 338 SER 339 0.0001

SER 339 LEU 340 0.0049

LEU 340 PRO 341 0.0001

PRO 341 ASP 342 -0.0003

ASP 342 TYR 343 0.0085

TYR 343 MET 344 0.0001

MET 344 LYS 345 0.0002

LYS 345 GLY 346 0.0194

GLY 346 VAL 347 -0.0002

VAL 347 TYR 348 0.0002

TYR 348 MET 349 0.0019

MET 349 VAL 350 -0.0001

VAL 350 LEU 351 0.0003

LEU 351 TYR 352 -0.0061

TYR 352 GLU 353 0.0000

GLU 353 ALA 354 0.0000

ALA 354 LEU 355 -0.0096

LEU 355 THR 356 0.0001

THR 356 GLU 357 -0.0000

GLU 357 MET 358 -0.0217

MET 358 ALA 359 0.0000

ALA 359 GLN 360 0.0001

GLN 360 GLU 361 0.0087

GLU 361 ALA 362 -0.0002

ALA 362 GLU 363 -0.0006

GLU 363 LYS 364 0.0033

LYS 364 THR 365 -0.0005

THR 365 GLN 366 0.0003

GLN 366 GLY 367 0.0028

GLY 367 ARG 368 0.0000

ARG 368 ASP 369 -0.0003

ASP 369 THR 370 0.0216

THR 370 LEU 371 0.0005

LEU 371 ASN 372 0.0000

ASN 372 TYR 373 -0.0198

TYR 373 ALA 374 0.0000

ALA 374 ARG 375 -0.0003

ARG 375 LYS 376 -0.0041

LYS 376 ALA 377 0.0005

ALA 377 TRP 378 -0.0002

TRP 378 GLU 379 0.0013

GLU 379 ILE 380 0.0004

ILE 380 TYR 381 0.0002

TYR 381 LEU 382 -0.0013

LEU 382 ASP 383 0.0000

ASP 383 SER 384 0.0001

SER 384 TYR 385 0.0035

TYR 385 ILE 386 -0.0000

ILE 386 GLN 387 -0.0001

GLN 387 GLU 388 0.0071

GLU 388 ALA 389 0.0002

ALA 389 LYS 390 0.0001

LYS 390 TRP 391 0.0044

TRP 391 ILE 392 0.0005

ILE 392 ALA 393 -0.0000

ALA 393 SER 394 -0.0237

SER 394 GLY 395 -0.0001

GLY 395 TYR 396 0.0001

TYR 396 LEU 397 0.0091

LEU 397 PRO 398 -0.0001

PRO 398 THR 399 -0.0000

THR 399 PHE 400 -0.0046

PHE 400 GLN 401 -0.0000

GLN 401 GLU 402 0.0002

GLU 402 TYR 403 -0.0237

TYR 403 PHE 404 0.0001

PHE 404 GLU 405 -0.0004

GLU 405 ASN 406 -0.0086

ASN 406 GLY 407 -0.0001

GLY 407 LYS 408 0.0005

LYS 408 ILE 409 -0.0043

ILE 409 SER 410 0.0004

SER 410 SER 411 0.0001

SER 411 ALA 412 0.0085

ALA 412 TYR 413 0.0002

TYR 413 ARG 414 0.0001

ARG 414 ALA 415 -0.0078

ALA 415 ALA 416 0.0001

ALA 416 ALA 417 -0.0002

ALA 417 LEU 418 -0.0052

LEU 418 THR 419 -0.0001

THR 419 PRO 420 0.0001

PRO 420 ILE 421 -0.0246

ILE 421 LEU 422 -0.0005

LEU 422 THR 423 0.0003

THR 423 LEU 424 -0.0290

LEU 424 ASP 425 -0.0000

ASP 425 VAL 426 -0.0002

VAL 426 PRO 427 0.0526

PRO 427 LEU 428 0.0003

LEU 428 PRO 429 -0.0000

PRO 429 GLU 430 0.0525

GLU 430 TYR 431 0.0001

TYR 431 ILE 432 0.0004

ILE 432 LEU 433 -0.0133

LEU 433 LYS 434 0.0001

LYS 434 GLY 435 0.0004

GLY 435 ILE 436 0.0098

ILE 436 ASP 437 -0.0003

ASP 437 PHE 438 0.0003

PHE 438 PRO 439 -0.0274

PRO 439 SER 440 -0.0005

SER 440 ARG 441 0.0004

ARG 441 PHE 442 0.0009

PHE 442 ASN 443 0.0002

ASN 443 ASP 444 -0.0002

ASP 444 LEU 445 -0.0179

LEU 445 ALA 446 -0.0003

ALA 446 SER 447 -0.0003

SER 447 SER 448 0.0214

SER 448 PHE 449 -0.0003

PHE 449 LEU 450 0.0003

LEU 450 ARG 451 -0.0026

ARG 451 LEU 452 0.0001

LEU 452 ARG 453 0.0003

ARG 453 GLY 454 0.0390

GLY 454 ASP 455 -0.0002

ASP 455 THR 456 -0.0002

THR 456 ARG 457 -0.0200

ARG 457 CYS 458 -0.0001

CYS 458 TYR 459 -0.0002

TYR 459 LYS 460 0.0014

LYS 460 ALA 461 -0.0001

ALA 461 ASP 462 -0.0001

ASP 462 ARG 463 -0.0045

ARG 463 ALA 464 -0.0000

ALA 464 ARG 465 0.0000

ARG 465 GLY 466 -0.0219

GLY 466 GLU 467 -0.0001

GLU 467 GLU 468 0.0002

GLU 468 ALA 469 0.0277

ALA 469 SER 470 0.0002

SER 470 CYS 471 0.0003

CYS 471 ILE 472 0.0145

ILE 472 SER 473 0.0004

SER 473 CYS 474 -0.0001

CYS 474 TYR 475 0.0101

TYR 475 MET 476 0.0001

MET 476 LYS 477 -0.0000

LYS 477 ASP 478 -0.0346

ASP 478 ASN 479 0.0002

ASN 479 PRO 480 0.0000

PRO 480 GLY 481 0.0196

GLY 481 SER 482 0.0004

SER 482 THR 483 -0.0002

THR 483 GLU 484 -0.0614

GLU 484 GLU 485 0.0000

GLU 485 ASP 486 -0.0001

ASP 486 ALA 487 -0.0028

ALA 487 LEU 488 -0.0002

LEU 488 ASN 489 -0.0002

ASN 489 HIS 490 0.0272

HIS 490 ILE 491 -0.0001

ILE 491 ASN 492 0.0005

ASN 492 SER 493 0.0396

SER 493 MET 494 0.0000

MET 494 ILE 495 -0.0000

ILE 495 ASN 496 0.0551

ASN 496 GLU 497 0.0004

GLU 497 ILE 498 0.0001

ILE 498 ILE 499 -0.0007

ILE 499 LYS 500 -0.0001

LYS 500 GLU 501 -0.0000

GLU 501 LEU 502 -0.0131

LEU 502 ASN 503 0.0001

ASN 503 TRP 504 0.0000

TRP 504 GLU 505 -0.0709

GLU 505 LEU 506 0.0001

LEU 506 LEU 507 0.0002

LEU 507 ARG 508 -0.0025

ARG 508 PRO 509 0.0001

PRO 509 ASP 510 0.0004

ASP 510 SER 511 -0.1354

SER 511 ASN 512 -0.0002

ASN 512 ILE 513 0.0002

ILE 513 PRO 514 0.0194

PRO 514 MET 515 -0.0001

MET 515 PRO 516 0.0004

PRO 516 ALA 517 0.0072

ALA 517 ARG 518 -0.0003

ARG 518 LYS 519 -0.0003

LYS 519 HIS 520 -0.0235

HIS 520 ALA 521 -0.0002

ALA 521 PHE 522 -0.0001

PHE 522 ASP 523 0.0101

ASP 523 ILE 524 -0.0000

ILE 524 THR 525 0.0000

THR 525 ARG 526 -0.0100

ARG 526 ALA 527 0.0002

ALA 527 LEU 528 -0.0002

LEU 528 HIS 529 -0.0044

HIS 529 HIS 530 -0.0002

HIS 530 LEU 531 -0.0002

LEU 531 TYR 532 -0.0702

TYR 532 LYS 533 -0.0000

LYS 533 TYR 534 0.0000

TYR 534 ARG 535 0.0672

ARG 535 ASP 536 -0.0000

ASP 536 GLY 537 0.0001

GLY 537 PHE 538 0.0663

PHE 538 SER 539 0.0003

SER 539 VAL 540 0.0002

VAL 540 ALA 541 -0.0653

ALA 541 THR 542 -0.0000

THR 542 LYS 543 -0.0000

LYS 543 GLU 544 0.0473

GLU 544 THR 545 -0.0002

THR 545 LYS 546 -0.0002

LYS 546 SER 547 -0.0087

SER 547 LEU 548 0.0003

LEU 548 VAL 549 0.0004

VAL 549 SER 550 0.0159

SER 550 ARG 551 0.0002

ARG 551 MET 552 0.0003

MET 552 VAL 553 0.0719

VAL 553 LEU 554 -0.0003

LEU 554 GLU 555 -0.0002

GLU 555 PRO 556 -0.0828

PRO 556 VAL 557 -0.0001

VAL 557 THR 558 0.0001

THR 558 LEU 559 -0.0290

If you find results from this site helpful for your research, please cite one of our papers:

K. Suhre & Y.H. Sanejouand, ElNemo: a normal mode web-server for protein movement analysis and the generation of templates for molecular replacement. Nucleic Acids Research, 32, W610-W614, 2004.
K. Suhre & Y.H. Sanejouand, On the potential of normal mode analysis for solving difficult molecular replacement problems. Acta Cryst. D vol.60, p796-799, 2004 © International Union of Crystallography.

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.

Should you encounter any unexpected behaviour, please let us know.

*** Q20HUZ_NMA ***

CA strain for 220512003338119574

--- normal mode 8 ---

Should you encounter any unexpected behaviour,
please let us know.

* Q20HUZ_NMA *