CNRS Nantes University UFIP UFIP
home |  start a new run |  job status |  references&downloads |  examples |  help  

Should you encounter any unexpected behaviour,
please let us know.


***  HYDROLASE 11-MAR-15 4YO9  ***

CA strain for 22032618020769270

---  normal mode 7  ---

This graph displays the distance variation between successive pairs of CA atoms in the two extreme conformations that were computed for this mode (DQMIN/DQMAX). Large distance variations can be an indicator for residue pairs that support the important strain in that particular normal mode movement. Note that residue pairs between chain breaks or at flexible ends of the protein may also exhibit large CA-CA distance variations. If more than one residues ae grouped together into a rigid block (NRBL>1), CA-CA distance variations between CA atoms in the same block will be very low.

This feature is still experimental and will be further developped in the future.

CA iCA i+1vari
SER 1GLY 2 -0.0001
GLY 2LEU 3 0.0001
LEU 3VAL 4 -0.0002
VAL 4LYS 5 -0.0062
LYS 5MET 6 0.0003
MET 6SER 7 0.0001
SER 7ALA 8 0.0002
ALA 8PRO 9 0.0035
PRO 9SER 10 -0.0004
SER 10GLY 11 0.0000
GLY 11ALA 12 0.0000
ALA 12VAL 13 0.0276
VAL 13GLU 14 -0.0002
GLU 14ASN 15 -0.0002
ASN 15CYS 16 0.0001
CYS 16ILE 17 -0.0075
ILE 17VAL 18 0.0000
VAL 18GLN 19 0.0003
GLN 19VAL 20 -0.0000
VAL 20THR 21 0.0310
THR 21CYS 22 0.0001
CYS 22GLY 23 -0.0002
GLY 23SER 24 0.0001
SER 24MET 25 -0.0139
MET 25THR 26 -0.0001
THR 26LEU 27 0.0002
LEU 27ASN 28 0.0000
ASN 28GLY 29 -0.0509
GLY 29LEU 30 0.0000
LEU 30TRP 31 0.0003
TRP 31LEU 32 0.0002
LEU 32ASP 33 -0.0053
ASP 33ASN 34 0.0000
ASN 34THR 35 0.0002
THR 35VAL 36 -0.0001
VAL 36TRP 37 -0.0057
TRP 37CYS 38 -0.0000
CYS 38PRO 39 0.0001
PRO 39ARG 40 0.0001
ARG 40HIS 41 0.0214
HIS 41ILE 42 0.0003
ILE 42MET 43 0.0000
MET 43CYS 44 -0.0002
CYS 44PRO 45 0.0056
PRO 45ALA 46 -0.0003
ALA 46ASP 47 0.0001
ASP 47GLN 48 0.0001
GLN 48LEU 49 -0.0081
LEU 49THR 50 -0.0001
THR 50ASP 51 -0.0002
ASP 51PRO 52 0.0002
PRO 52ASN 53 -0.0120
ASN 53TYR 54 -0.0004
TYR 54ASP 55 -0.0002
ASP 55ALA 56 -0.0001
ALA 56LEU 57 0.0009
LEU 57LEU 58 -0.0001
LEU 58ILE 59 0.0000
ILE 59SER 60 0.0000
SER 60LYS 61 -0.0011
LYS 61THR 62 0.0002
THR 62ASN 63 -0.0001
ASN 63HIS 64 -0.0004
HIS 64SER 65 -0.0062
SER 65PHE 66 0.0004
PHE 66ILE 67 -0.0003
ILE 67VAL 68 0.0001
VAL 68GLN 69 0.0006
GLN 69LYS 70 -0.0002
LYS 70HIS 71 0.0002
HIS 71ILE 72 0.0002
ILE 72GLY 73 -0.0113
GLY 73ALA 74 -0.0002
ALA 74GLN 75 -0.0003
GLN 75ALA 76 -0.0001
ALA 76ASN 77 -0.0167
ASN 77LEU 78 -0.0002
LEU 78ARG 79 0.0002
ARG 79VAL 80 -0.0003
VAL 80VAL 81 -0.0149
VAL 81ALA 82 -0.0002
ALA 82HIS 83 0.0002
HIS 83SER 84 0.0002
SER 84MET 85 -0.0042
MET 85VAL 86 0.0001
VAL 86GLY 87 -0.0001
GLY 87VAL 88 0.0003
VAL 88LEU 89 0.0010
LEU 89LEU 90 -0.0001
LEU 90LYS 91 0.0003
LYS 91LEU 92 -0.0001
LEU 92THR 93 -0.0102
THR 93VAL 94 -0.0001
VAL 94ASP 95 -0.0001
ASP 95VAL 96 0.0001
VAL 96ALA 97 0.0202
ALA 97ASN 98 0.0001
ASN 98PRO 99 -0.0002
PRO 99SER 100 0.0003
SER 100THR 101 -0.0112
THR 101PRO 102 -0.0000
PRO 102ALA 103 0.0001
ALA 103TYR 104 -0.0000
TYR 104THR 105 -0.0155
THR 105PHE 106 -0.0002
PHE 106SER 107 0.0000
SER 107THR 108 -0.0002
THR 108VAL 109 0.1149
VAL 109LYS 110 0.0004
LYS 110PRO 111 -0.0003
PRO 111GLY 112 0.0003
GLY 112ALA 113 -0.0683
ALA 113SER 114 0.0003
SER 114PHE 115 -0.0002
PHE 115SER 116 -0.0002
SER 116VAL 117 -0.0002
VAL 117LEU 118 0.0001
LEU 118ALA 119 -0.0000
ALA 119CYS 120 -0.0001
CYS 120TYR 121 0.0084
TYR 121ASN 122 -0.0000
ASN 122GLY 123 0.0002
GLY 123LYS 124 -0.0000
LYS 124PRO 125 0.0016
PRO 125THR 126 0.0002
THR 126GLY 127 -0.0002
GLY 127VAL 128 0.0002
VAL 128PHE 129 0.0341
PHE 129THR 130 -0.0002
THR 130VAL 131 0.0004
VAL 131ASN 132 -0.0002
ASN 132LEU 133 0.0082
LEU 133ARG 134 0.0001
ARG 134HIS 135 0.0002
HIS 135ASN 136 0.0001
ASN 136SER 137 -0.0044
SER 137THR 138 0.0003
THR 138ILE 139 -0.0001
ILE 139LYS 140 0.0004
LYS 140GLY 141 0.0429
GLY 141SER 142 -0.0002
SER 142PHE 143 0.0001
PHE 143LEU 144 0.0001
LEU 144CYS 145 -0.1167
CYS 145GLY 146 0.0003
GLY 146SER 147 -0.0001
SER 147CYS 148 -0.0000
CYS 148GLY 149 -0.0364
GLY 149SER 150 -0.0002
SER 150VAL 151 0.0003
VAL 151GLY 152 0.0004
GLY 152TYR 153 -0.0062
TYR 153THR 154 -0.0003
THR 154GLU 155 0.0004
GLU 155ASN 156 0.0002
ASN 156GLY 157 0.0114
GLY 157GLY 158 -0.0001
GLY 158VAL 159 -0.0000
VAL 159ILE 160 0.0002
ILE 160ASN 161 -0.0295
ASN 161PHE 162 0.0001
PHE 162VAL 163 0.0001
VAL 163TYR 164 0.0000
TYR 164MET 165 0.0085
MET 165HIS 166 0.0000
HIS 166GLN 167 0.0002
GLN 167MET 168 0.0004
MET 168GLU 169 -0.0699
GLU 169LEU 170 -0.0000
LEU 170SER 171 -0.0003
SER 171ASN 172 0.0003
ASN 172GLY 173 0.0013
GLY 173THR 174 0.0000
THR 174HIS 175 -0.0001
HIS 175THR 176 -0.0003
THR 176GLY 177 -0.0174
GLY 177SER 178 0.0000
SER 178SER 179 -0.0004
SER 179PHE 180 0.0003
PHE 180ASP 181 -0.0075
ASP 181GLY 182 0.0002
GLY 182VAL 183 -0.0001
VAL 183MET 184 -0.0002
MET 184TYR 185 0.0228
TYR 185GLY 186 0.0001
GLY 186ALA 187 -0.0001
ALA 187PHE 188 0.0000
PHE 188GLU 189 0.0094
GLU 189ASP 190 -0.0000
ASP 190LYS 191 0.0001
LYS 191GLN 192 -0.0004
GLN 192THR 193 0.0032
THR 193HIS 194 -0.0000
HIS 194GLN 195 0.0006
GLN 195LEU 196 -0.0003
LEU 196GLN 197 -0.0326
GLN 197LEU 198 0.0001
LEU 198THR 199 -0.0002
THR 199ASP 200 0.0002
ASP 200LYS 201 -0.0492
LYS 201TYR 202 -0.0001
TYR 202CYS 203 -0.0000
CYS 203THR 204 0.0002
THR 204ILE 205 -0.0231
ILE 205ASN 206 0.0001
ASN 206VAL 207 -0.0002
VAL 207VAL 208 -0.0000
VAL 208ALA 209 -0.0391
ALA 209TRP 210 -0.0001
TRP 210LEU 211 0.0001
LEU 211TYR 212 0.0003
TYR 212ALA 213 -0.0226
ALA 213ALA 214 0.0001
ALA 214VAL 215 0.0001
VAL 215LEU 216 0.0001
LEU 216ASN 217 -0.0324
ASN 217GLY 218 -0.0001
GLY 218CYS 219 0.0000
CYS 219LYS 220 -0.0001
LYS 220TRP 221 -0.0103
TRP 221PHE 222 -0.0000
PHE 222VAL 223 0.0001
VAL 223LYS 224 0.0003
LYS 224PRO 225 0.0004
PRO 225THR 226 -0.0002
THR 226ARG 227 -0.0001
ARG 227VAL 228 0.0000
VAL 228GLY 229 0.0165
GLY 229ILE 230 0.0002
ILE 230VAL 231 0.0003
VAL 231THR 232 0.0001
THR 232TYR 233 0.0095
TYR 233ASN 234 -0.0002
ASN 234GLU 235 0.0000
GLU 235TRP 236 -0.0001
TRP 236ALA 237 -0.0010
ALA 237LEU 238 -0.0001
LEU 238SER 239 0.0001
SER 239ASN 240 0.0001
ASN 240GLN 241 -0.0341
GLN 241PHE 242 0.0001
PHE 242THR 243 0.0002
THR 243GLU 244 -0.0001
GLU 244PHE 245 0.0080
PHE 245VAL 246 0.0002
VAL 246GLY 247 -0.0002
GLY 247THR 248 0.0000
THR 248GLN 249 0.0075
GLN 249SER 250 0.0002
SER 250ILE 251 0.0000
ILE 251ASP 252 -0.0003
ASP 252MET 253 0.0201
MET 253LEU 254 -0.0003
LEU 254ALA 255 -0.0001
ALA 255HIS 256 0.0001
HIS 256ARG 257 -0.0183
ARG 257THR 258 0.0001
THR 258GLY 259 -0.0001
GLY 259VAL 260 0.0001
VAL 260SER 261 -0.0118
SER 261VAL 262 -0.0003
VAL 262GLU 263 -0.0001
GLU 263GLN 264 0.0001
GLN 264MET 265 0.0136
MET 265LEU 266 0.0001
LEU 266ALA 267 -0.0004
ALA 267ALA 268 -0.0001
ALA 268ILE 269 -0.0062
ILE 269GLN 270 0.0002
GLN 270SER 271 0.0001
SER 271SER 271 0.0195
SER 271LEU 272 -0.0001
LEU 272HIS 273 -0.0218
HIS 273ALA 274 0.0001
ALA 274GLY 275 -0.0002
GLY 275PHE 276 -0.0002
PHE 276GLN 277 -0.0073
GLN 277GLY 278 -0.0003
GLY 278LYS 279 -0.0003
LYS 279THR 280 0.0006
THR 280ILE 281 0.0137
ILE 281LEU 282 -0.0000
LEU 282GLY 283 0.0001
GLY 283GLN 284 0.0003
GLN 284SER 285 -0.0251
SER 285THR 286 -0.0003
THR 286LEU 287 0.0002
LEU 287GLU 288 -0.0002
GLU 288ASP 289 0.0383
ASP 289GLU 290 0.0004
GLU 290PHE 291 0.0001
PHE 291THR 292 0.0002
THR 292PRO 293 0.0642
PRO 293ASP 294 0.0001
ASP 294ASP 295 -0.0001
ASP 295VAL 296 -0.0000
VAL 296ASN 297 -0.0028
ASN 297MET 298 -0.0001
MET 298GLN 299 -0.0002
GLN 299VAL 300 -0.0003
VAL 300MET 301 -0.0642
MET 301GLY 302 0.0000
GLY 302VAL 303 -0.0004
VAL 303VAL 304 0.0002
VAL 304MET 305 -0.0143
MET 305GLN 306 -0.0001
GLN 306SER 1 0.0841
SER 1GLY 2 0.0003
GLY 2LEU 3 -0.0001
LEU 3VAL 4 0.0001
VAL 4LYS 5 -0.0078
LYS 5MET 6 0.0002
MET 6SER 7 -0.0001
SER 7ALA 8 -0.0003
ALA 8PRO 9 -0.0003
PRO 9SER 10 0.0002
SER 10GLY 11 0.0002
GLY 11ALA 12 0.0002
ALA 12VAL 13 0.0212
VAL 13GLU 14 -0.0001
GLU 14ASN 15 0.0001
ASN 15CYS 16 0.0001
CYS 16ILE 17 -0.0049
ILE 17VAL 18 0.0001
VAL 18GLN 19 -0.0001
GLN 19VAL 20 0.0000
VAL 20THR 21 0.0253
THR 21CYS 22 -0.0000
CYS 22GLY 23 0.0001
GLY 23SER 24 0.0003
SER 24MET 25 -0.0265
MET 25THR 26 -0.0004
THR 26LEU 27 -0.0002
LEU 27ASN 28 -0.0001
ASN 28GLY 29 -0.0451
GLY 29LEU 30 -0.0003
LEU 30TRP 31 -0.0002
TRP 31LEU 32 -0.0000
LEU 32ASP 33 -0.0035
ASP 33ASN 34 -0.0004
ASN 34THR 35 -0.0000
THR 35VAL 36 0.0004
VAL 36TRP 37 -0.0033
TRP 37CYS 38 0.0000
CYS 38PRO 39 -0.0001
PRO 39ARG 40 0.0002
ARG 40HIS 41 0.0148
HIS 41ILE 42 -0.0004
ILE 42MET 43 -0.0001
MET 43CYS 44 0.0001
CYS 44PRO 45 0.0192
PRO 45ALA 46 -0.0001
ALA 46ASP 47 -0.0000
ASP 47GLN 48 -0.0001
GLN 48LEU 49 0.0085
LEU 49THR 50 -0.0002
THR 50ASP 51 -0.0005
ASP 51ASP 51 -0.0175
ASP 51PRO 52 -0.0000
PRO 52ASN 53 -0.0016
ASN 53TYR 54 -0.0002
TYR 54ASP 55 0.0003
ASP 55ALA 56 -0.0002
ALA 56LEU 57 -0.0007
LEU 57LEU 58 0.0002
LEU 58ILE 59 0.0001
ILE 59SER 60 0.0001
SER 60LYS 61 -0.0029
LYS 61THR 62 -0.0001
THR 62ASN 63 -0.0000
ASN 63HIS 64 0.0000
HIS 64SER 65 -0.0042
SER 65PHE 66 -0.0001
PHE 66ILE 67 0.0002
ILE 67VAL 68 -0.0000
VAL 68GLN 69 0.0062
GLN 69LYS 70 -0.0003
LYS 70HIS 71 0.0000
HIS 71ILE 72 0.0003
ILE 72GLY 73 -0.0046
GLY 73ALA 74 0.0002
ALA 74GLN 75 0.0002
GLN 75ALA 76 -0.0002
ALA 76ASN 77 0.0014
ASN 77LEU 78 0.0003
LEU 78ARG 79 0.0003
ARG 79VAL 80 0.0002
VAL 80VAL 81 -0.0166
VAL 81ALA 82 -0.0002
ALA 82HIS 83 -0.0001
HIS 83SER 84 0.0001
SER 84MET 85 -0.0004
MET 85VAL 86 0.0000
VAL 86GLY 87 0.0000
GLY 87VAL 88 0.0005
VAL 88LEU 89 0.0024
LEU 89LEU 90 -0.0002
LEU 90LYS 91 -0.0001
LYS 91LEU 92 -0.0000
LEU 92THR 93 -0.0082
THR 93VAL 94 -0.0001
VAL 94ASP 95 -0.0000
ASP 95VAL 96 -0.0000
VAL 96ALA 97 0.0182
ALA 97ASN 98 -0.0000
ASN 98PRO 99 0.0004
PRO 99SER 100 0.0002
SER 100THR 101 -0.0089
THR 101PRO 102 -0.0002
PRO 102ALA 103 -0.0001
ALA 103TYR 104 0.0002
TYR 104THR 105 -0.0125
THR 105PHE 106 -0.0000
PHE 106SER 107 -0.0001
SER 107THR 108 0.0003
THR 108VAL 109 0.1012
VAL 109LYS 110 -0.0001
LYS 110PRO 111 0.0003
PRO 111GLY 112 0.0004
GLY 112ALA 113 -0.0634
ALA 113SER 114 -0.0000
SER 114PHE 115 0.0002
PHE 115SER 116 0.0002
SER 116VAL 117 -0.0142
VAL 117LEU 118 0.0004
LEU 118ALA 119 -0.0001
ALA 119CYS 120 0.0001
CYS 120TYR 121 0.0059
TYR 121ASN 122 0.0004
ASN 122GLY 123 -0.0000
GLY 123LYS 124 0.0001
LYS 124PRO 125 -0.0223
PRO 125THR 126 0.0003
THR 126GLY 127 -0.0002
GLY 127VAL 128 -0.0001
VAL 128PHE 129 0.0351
PHE 129THR 130 -0.0002
THR 130VAL 131 0.0002
VAL 131ASN 132 -0.0000
ASN 132ASN 132 0.0336
ASN 132LEU 133 0.0147
LEU 133ARG 134 -0.0000
ARG 134HIS 135 0.0004
HIS 135ASN 136 0.0001
ASN 136SER 137 -0.0025
SER 137THR 138 -0.0004
THR 138ILE 139 -0.0000
ILE 139LYS 140 -0.0002
LYS 140GLY 141 0.0353
GLY 141SER 142 -0.0000
SER 142PHE 143 0.0001
PHE 143LEU 144 -0.0001
LEU 144CYS 145 -0.1313
CYS 145GLY 146 -0.0000
GLY 146SER 147 -0.0000
SER 147CYS 148 0.0001
CYS 148GLY 149 -0.0462
GLY 149SER 150 -0.0000
SER 150VAL 151 0.0000
VAL 151GLY 152 -0.0002
GLY 152TYR 153 -0.0196
TYR 153THR 154 0.0000
THR 154GLU 155 -0.0004
GLU 155ASN 156 0.0002
ASN 156GLY 157 0.0074
GLY 157GLY 158 0.0002
GLY 158VAL 159 0.0001
VAL 159ILE 160 0.0001
ILE 160ASN 161 -0.0336
ASN 161PHE 162 0.0002
PHE 162VAL 163 0.0001
VAL 163TYR 164 0.0001
TYR 164MET 165 0.0070
MET 165HIS 166 -0.0001
HIS 166GLN 167 -0.0003
GLN 167MET 168 0.0005
MET 168GLU 169 -0.0476
GLU 169LEU 170 -0.0001
LEU 170SER 171 0.0001
SER 171ASN 172 0.0001
ASN 172GLY 173 -0.0038
GLY 173THR 174 0.0000
THR 174HIS 175 -0.0003
HIS 175THR 176 0.0004
THR 176GLY 177 -0.0244
GLY 177SER 178 0.0002
SER 178SER 179 0.0001
SER 179PHE 180 -0.0004
PHE 180ASP 181 -0.0082
ASP 181GLY 182 -0.0003
GLY 182VAL 183 0.0003
VAL 183MET 184 0.0002
MET 184TYR 185 0.0263
TYR 185GLY 186 0.0000
GLY 186ALA 187 -0.0004
ALA 187PHE 188 -0.0003
PHE 188GLU 189 0.0191
GLU 189ASP 190 0.0004
ASP 190LYS 191 0.0000
LYS 191GLN 192 0.0003
GLN 192THR 193 0.0114
THR 193HIS 194 0.0003
HIS 194GLN 195 0.0000
GLN 195LEU 196 0.0003
LEU 196GLN 197 -0.0058
GLN 197LEU 198 0.0000
LEU 198THR 199 -0.0001
THR 199ASP 200 -0.0003
ASP 200LYS 201 -0.0355
LYS 201TYR 202 0.0001
TYR 202CYS 203 0.0000
CYS 203THR 204 -0.0002
THR 204ILE 205 -0.0281
ILE 205ASN 206 -0.0003
ASN 206VAL 207 -0.0003
VAL 207VAL 208 0.0002
VAL 208ALA 209 -0.0260
ALA 209TRP 210 -0.0001
TRP 210LEU 211 0.0001
LEU 211TYR 212 -0.0002
TYR 212ALA 213 -0.0201
ALA 213ALA 214 0.0002
ALA 214VAL 215 -0.0000
VAL 215LEU 216 0.0001
LEU 216ASN 217 0.0016
ASN 217GLY 218 0.0003
GLY 218CYS 219 0.0005
CYS 219LYS 220 -0.0004
LYS 220TRP 221 -0.0136
TRP 221PHE 222 0.0001
PHE 222VAL 223 -0.0004
VAL 223LYS 224 0.0003
LYS 224PRO 225 0.0004
PRO 225THR 226 0.0001
THR 226ARG 227 -0.0000
ARG 227VAL 228 0.0001
VAL 228GLY 229 0.0075
GLY 229ILE 230 0.0001
ILE 230VAL 231 0.0000
VAL 231THR 232 -0.0001
THR 232TYR 233 0.0066
TYR 233ASN 234 -0.0001
ASN 234GLU 235 -0.0001
GLU 235TRP 236 0.0004
TRP 236ALA 237 0.0009
ALA 237LEU 238 0.0001
LEU 238SER 239 0.0003
SER 239ASN 240 -0.0002
ASN 240GLN 241 -0.0153
GLN 241PHE 242 0.0001
PHE 242THR 243 -0.0002
THR 243GLU 244 0.0000
GLU 244PHE 245 -0.0010
PHE 245VAL 246 -0.0002
VAL 246GLY 247 0.0001
GLY 247THR 248 -0.0000
THR 248GLN 249 -0.0188
GLN 249SER 250 0.0002
SER 250ILE 251 0.0001
ILE 251ASP 252 -0.0001
ASP 252MET 253 -0.0055
MET 253LEU 254 -0.0000
LEU 254ALA 255 0.0000
ALA 255HIS 256 0.0002
HIS 256ARG 257 -0.0043
ARG 257THR 258 0.0004
THR 258GLY 259 0.0005
GLY 259VAL 260 -0.0002
VAL 260SER 261 -0.0076
SER 261VAL 262 -0.0001
VAL 262GLU 263 0.0001
GLU 263GLN 264 -0.0001
GLN 264MET 265 0.0078
MET 265LEU 266 0.0002
LEU 266ALA 267 0.0001
ALA 267ALA 268 -0.0003
ALA 268ILE 269 -0.0020
ILE 269GLN 270 -0.0002
GLN 270SER 271 0.0004
SER 271LEU 272 0.0004
LEU 272HIS 273 -0.0196
HIS 273ALA 274 -0.0001
ALA 274GLY 275 -0.0001
GLY 275PHE 276 0.0000
PHE 276GLN 277 -0.0017
GLN 277GLY 278 -0.0000
GLY 278LYS 279 -0.0003
LYS 279THR 280 -0.0002
THR 280ILE 281 0.0051
ILE 281LEU 282 0.0003
LEU 282GLY 283 0.0002
GLY 283GLN 284 0.0001
GLN 284SER 285 -0.0321
SER 285THR 286 -0.0005
THR 286LEU 287 0.0003
LEU 287GLU 288 -0.0002
GLU 288ASP 289 0.0384
ASP 289GLU 290 -0.0000
GLU 290PHE 291 0.0005
PHE 291THR 292 -0.0004
THR 292PRO 293 0.0243
PRO 293ASP 294 0.0001
ASP 294ASP 295 0.0003
ASP 295VAL 296 -0.0002
VAL 296ASN 297 -0.0185
ASN 297MET 298 -0.0000
MET 298GLN 299 -0.0004
GLN 299VAL 300 0.0004
VAL 300MET 301 0.0364

If you find results from this site helpful for your research, please cite one of our papers:

elNémo is maintained by Yves-Henri Sanejouand.
It was developed by Karsten Suhre.
Between 2003 and 2014, it was hosted by IGS (Marseille).
Last modification: October 18th, 2018.