The coordination properties of phosphonic acids (RPO3H2) and their « phosphate » analogues (ROPO3H2) with metal cations, can be used to modify inorganic surfaces and obtain functional materials. In this context, two main applications are currently developed in the field of biotechnologies : (1) Design of drug-device combinations for the prevention of osteoporotic fractures (2) Innovating technologies for the design of novel substrates for the preparation of biological microarrays (oligononucleotide, ds-DNA and protein microarrays)
Project 1 :Novel drug-device combinations for the prevention of osteoporotic fractures.
Our purpose is to develop various technological solutions for the design of novel drug-device combinations, based on bone resorption inhibitors (bisphosphonates) associated to calcium phosphates. Accordingly, injectable biomaterials can be obtained, which are resorbable and can be implanted under minimally invasive surgery, thus offering great potential for the prevention of osteoporotic fractures (femur neck, spine).
Research team : B Bujoli, P Janvier, M Petit,
C Mellier (PhD)
Project funding : ANR, CNRS,Graftys company, Pays de la Loire region
Research network :
LIOAD, UMR INSERM 791 (JM Bouler, J Guicheux, O Gauthier).
Novel drug-device combinations for the prevention of the osteoporotic fracture.
Publications-Novel drug-device combinations for the prevention of the osteoporotic fracture
Project 2 : Innovating supports for the design of biological microarrays. .
Our purpose is to develop novel surface chemistry, allowing efficient grafting of biological probes (oligonucleotides, ds-DNA, proteins) under reproducible and controlled conditions via a natural modification of the probes (i.e. phosphate groups).